MCID: GTR002
MIFTS: 55

Goiter malady

Summaries for Goiter

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 A goitre or goiter (Latin gutteria, struma), is a swelling of the neck or larynx resulting from... more...

MalaCards: Goiter is related to endemic goiter and multinodular goiter. An important gene associated with Goiter is TG (thyroglobulin), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Allograft rejection. The drugs methimazole and propylthiouracil and the compounds tyrosine and arginine have been mentioned in the context of this disorder. Related mouse phenotypes are homeostasis/metabolism and nervous system.

Disease Ontology:8 A thyroid gland disease that involves an abnormal enlargement of the thyroid gland.

Aliases & Classifications for Goiter

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt, 27ICD9CM
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Aliases & Descriptions:

goiter 8 10 45 61


External Ids:

Disease Ontology8 DOID:12176
MeSH35 D006042
NCIt40 C26785
ICD9CM27 240.9

Related Diseases for Goiter

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Goiter family:

goiter, familial, due to ttf-1 defect

Diseases related to Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 243)
idRelated DiseaseScoreTop Affiliating Genes
1endemic goiter31.6TSHR, TPO, TG
2multinodular goiter31.6SLC26A4, KRT19, TSHR, ADCY10, TPO, TG
3nodular goiter31.5TPO, TG, TSHR, LGALS3, KRT19, CALCA
4nontoxic goiter31.3BGLAP, TSHR, TPO, TG
5graves' disease31.0TSHR, GNAS
6thyroid cancer31.0CALCA, GNAS, NKX2-1, TRH, THRB, SLC26A4
7adenoma30.9CALCA, GNAS, NKX2-1, TRH, IL6R, THRB
8toxic diffuse goiter30.9TSHR, TPO, TG
9pendred syndrome30.8SLC26A4, TPO, TG
10papillary carcinoma30.7TG, TPO, CALCA, GNAS, NKX2-1, SLC26A4
11thyrotoxicosis30.7TRH, THRB, SERPINA7, TSHR, TPO, TG
12thyroiditis30.7TG, TPO, CALCA, TRH, SERPINA7, TSHR
13congenital hypothyroidism30.7GNAS, NKX2-1, SERPINA7, TSHR, TPO, TG
14thyroid adenoma30.6LGALS3, SERPINA7, TSHR, TPO, TG, GNAS
15autoimmune thyroiditis30.4CALCA, TPO, TG
16plummer's disease30.4TG, TPO, ICAM1
17thyroid medullary carcinoma30.2CALCA, NKX2-1, LGALS3, TG
18myxedema30.2TSHR, TPO, TG
19acromegaly30.1ADCY10, TRH, GNAS, BGLAP
20arthritis30.1IL6R, ICAM1, CALCA, BGLAP
21mental retardation29.9GNAS, THRB, TSHR
22thymoma29.9NKX2-1
23mccune albright syndrome29.9GNAS
24thyroid cancer, anaplastic29.7CALCA, NKX2-1, SLC26A4, LGALS3, TSHR, TPO
25hyperthyroxinemia29.7TRH, SERPINA7, TSHR, TPO
26thyroid hormone resistance syndrome29.7TRH, THRB, SERPINA7, TG
27subacute thyroiditis29.7TPO, TSHR, TG
28struma ovarii29.7NKX2-1, TSHR, TG
29paraganglioma29.7TG, CALCA
30fibrous dysplasia29.7BGLAP, GNAS, ADCY10
31adenocarcinoma29.7ADCY10, LGALS3, KRT19, NKX2-1
32hypoparathyroidism29.7CALCA, BGLAP
33addison's disease29.7TPO, TG
34tuberculosis29.7GSR, TPO, ADCY10
35amenorrhea29.7TRH
36substernal goiter10.8
37primary hyperparathyroidism10.4
38lingual goiter10.3
39amyloidosis10.3
40superior vena cava syndrome10.2
41thyroid lymphoma10.2
42bird-headed dwarfism with progressive ataxia, insulin-resistant diabetes, goiter and primary gonadal insufficiency10.2
43daneman davy mancer syndrome10.2
44goiter, multinodular 1, with or without sertoli-leydig cell tumors10.2
45dyshormonogenic goiter10.1
46iodine hypothyroidism10.1
47tracheal stenosis10.1
48mutism10.1
49horner's syndrome10.1
50deafness goiter stippled epiphyses10.1

Graphical network of the top 20 diseases related to Goiter:



Diseases related to goiter

Clinical Features for Goiter

Drugs & Therapeutics for Goiter

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Goiter

Drug clinical trials:

Search ClinicalTrials for Goiter

Search NIH Clinical Center for Goiter

Search CenterWatch for Goiter

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Goiter

Anatomical Context for Goiter

Animal Models for Goiter or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Goiter

Sources:
51PubMed
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Articles related to Goiter:

(show top 50)    (show all 1410)
idTitleAuthorsYear
1
Regulatory T cells and plasmacytoid dendritic cells contribute to the immune escape of papillary thyroid cancer coexisting with multinodular non-toxic goiter. (23264145)
2013
2
Growth inhibition of human thyroid carcinoma and goiter cells in vitro by the isoflavone derivative 7-(O)-carboxymethyl daidzein conjugated to N-t-boc-hexylenediamine. (22799572)
2012
3
Mediastinal goiter: a comprehensive study of 60 consecutive cases with special emphasis on identifying predictors of malignancy and sternotomy. (21890099)
2012
4
Total thyroidectomy for non-toxic multinodular goiter with versus without the use of harmonic FOCUS dissecting shears - a prospective randomized study. (23362426)
2012
5
Mass effect of a thyroid goiter that crimps the great vessels. (21805816)
2011
6
Aberrant DNA methylation of drug metabolism and transport genes in nodular goiter. (21988780)
2011
7
Absence of primary hypothyroidism and goiter in Slc26a4 (-/-) mice fed on a low iodine diet. (20834201)
2011
8
Approach to management of the patient with primary or secondary intrathoracic goiter. (21131536)
2010
9
Goiter depicted in Byzantine artworks. (21112867)
2010
10
Vitamin A status does not contribute to the residual goiter in schoolchildren of Isfahan, an iodine replenished area. (19115122)
2009
11
Immigration and the incidence of Graves' thyrotoxicosis, thyrotoxic multinodular goiter and solitary toxic adenoma. (19004985)
2009
12
Surgical management of tracheal compression caused by mediastinal goiter: is extracorporeal circulation requisite? (22263003)
2009
13
The odyssey of nontoxic nodular goiter (NTNG) in Greece under suppression therapy, and after improvement of iodine deficiency. (18578614)
2008
14
Can ultrasound and clinical features be used to predict thyroid cancer in solitary nodules and multinodular goiter? (17290235)
2007
15
Low serum selenium concentration as a possible factor for persistent goiter in Iranian school children. (17673823)
2007
16
Clinical case seminar: metastatic follicular thyroid carcinoma arising from congenital goiter as a result of a novel splice donor site mutation in the thyroglobulin gene. (16403815)
2006
17
Squamous metaplasia in a multinodular goiter: a case report. (15027744)
2003
18
Novel technique for control of mediastinal bleeding during thyroidectomy for substernal goiter. (12742217)
2003
19
Cytologic appearance of toxic nodular goiter after thyrostatic treatment. A karyometric study. (12630081)
2003
20
Incidence of differentiated cancer in nodular goiter. (12235469)
2002
21
Surgical treatment of multinodular goiter: incidence of lesions of the recurrent nerves after total thyroidectomy. (11324993)
2000
22
Expression of transforming growth factor beta1, beta2, and beta3 in multinodular goiters and differentiated thyroid carcinomas: a comparative study. (10090310)
1999
23
Activating thyrotropin receptor mutations in histologically heterogeneous hyperfunctioning nodules of multinodular goiter. (9709907)
1998
24
Progress against endemic goiter in Croatia--mandatory salt iodination increased after 40 years of implementation. (9294783)
1997
25
Toxic nodular goiter and thymic hyperplasia in an adult. Case report. (9557476)
1997
26
Case in point. Multinodular goiter and papillary carcinoma. (8609189)
1996
27
Goiter prevalence in children immigrating from an endemic goiter area in Ethiopia to Israel. (7584706)
1995
28
Immunohistochemical studies on thyroid peroxidase and thyroglobulin in 13 human thyroid tumors and 7 Graves' goiters. (7951537)
1993
29
Circadian and seasonal variation in iodine excretion in children in an endemic goiter area. (2217288)
1990
30
Clinical, laboratory and immunologic effects of the treatment of endemic goiter with T4, T3 and KI. (1724914)
1990
31
Pathogenesis of nodular goiter and its implications for surgical management. (3336872)
1988
32
Pathogenetic relevance of HLA class II expressing thyroid follicular cells in nontoxic Goiter and in Graves' disease. (3130398)
1988
33
Toxic multinodular goiter: a variant of autoimmune hyperthyroidism. (2888784)
1987
34
Changes of the blood lymphocyte population following 131I treatment for nodular goiter. (3818387)
1987
35
Sequestered substernal goiter. (6625801)
1983
36
Immunological characterization of mononuclear cells in thyroid gland and blood in Graves' disease, multinodular goiter and papillary carcinoma. (6896702)
1982
37
Epidemiologic survey of endemic goiter and cretinism in Guizhou. (6802583)
1982
38
Studies on the effect of salt iodization on endemic goiter, Taiwan. I. Mass survey on goiter of school children. (1068220)
1976
39
Substernal goiter with superior vena caval obstruction. (1129707)
1975
40
Neonatal hypothyroidism and goiter in one infant of each of two sets of twins due to maternal therapy with antithyroid drugs. (4135477)
1974
41
Endemic goiter in the Cauca Valley. 3. Role of serum TSH in goitrogenesis. (5547271)
1971
42
Substernal goiter. (5428874)
1970
43
Pathogenesis and treatment of nodular goiter. (13942485)
1963
44
The surgical treatment of non-toxic nodular goiter. (13883878)
1961
45
Nontoxic goiter. (13812866)
1960
46
Endemic goiter in Latin America. (14444295)
1960
47
Prevention of endemic goiter and evaluation of enlargement of the thyroid gland; answer to the critics]. (13658082)
1959
48
Differential diagnosis, pathology, and treatment of substernal goiter. (13398297)
1957
49
The history of the use of iodine in toxic diffuse goiter (Graves' disease). (13457495)
1957
50
The adenomatous or nodular goiter. (14841773)
1951

Genetic Variations for Goiter

Expression for genes affiliated with Goiter

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Goiter

Search GEO for disease gene expression data for Goiter.

Pathways for genes affiliated with Goiter

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore
See all sources

Pathways related to Goiter according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6THRB, TSHR, GNAS, CALCA, TRH
2
Hide members
10.5TG, TPO, TSHR
3
Hide members
10.5TPO, GSR, TG
410.5GNAS, ADCY10, CALCA
5
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.5BGLAP, THRB, CALCA

Compounds for genes affiliated with Goiter

Sources:
45Novoseek, 24HMDB, 2BitterDB, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 50PharmGKB
See all sources

Compounds related to Goiter according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1tyrosine4511.1THRB, SLC26A4, KRT19, LGALS3, SERPINA7, TSHR
2arginine4511.1IL6R, BGLAP, ADCY10, TSHR, SERPINA7, LGALS3
3thyroxine45 2412.1BGLAP, CALCA, TRH, THRB, TG, GSR
4ribonucleic acid4511.1THRB, IL6R, NKX2-1, GNAS, KRT19, SERPINA7
5iodine45 2412.0TPO, TSHR, SERPINA7, TG, GNAS, TRH
6methimazole45 2 1113.0GSR, BGLAP, ICAM1, TRH, SERPINA7, TSHR
7retinoic acid45 2412.0TSHR, TPO, TG, THRB, LGALS3, IL6R
8triiodothyronine4511.0TPO, TSHR, TG, SERPINA7, SLC26A4, THRB
9guanine45 11 2413.0ICAM1, THRB, TSHR, ADCY10, TG, CALCA
10progesterone45 60 29 11 2415.0TSHR, TRH, NKX2-1, KRT19, SERPINA7, LGALS3
11testosterone45 60 11 2414.0TG, IL6R, TPO, SERPINA7, KRT19, THRB
12adenylate4511.0CALCA, ADCY10, TPO, GSR, TG, GNAS
13sodium iodide4511.0NKX2-1, SLC26A4, TPO, TSHR, TG
14iodide45 2412.0SERPINA7, SLC26A4, TG, NKX2-1, TPO
15acth4511.0TRH, LGALS3, TPO, SERPINA7, TSHR, GNAS
16creatinine4511.0GSR, TPO, IL6R, KRT19, BGLAP, TG
17estrogen4511.0TRH, TG, TSHR, SERPINA7
18vegf4511.0TSHR, KRT19, LGALS3, IL6R, ICAM1, BGLAP
19octreotide45 60 29 1114.0TG, ADCY10, TRH, GNAS, CALCA
20alanine4511.0GSR, THRB, TSHR, SERPINA7, LGALS3, GNAS
21aspartate4510.9TSHR, SERPINA7, KRT19, BGLAP, TPO, GSR
22polysaccharide4510.9LGALS3, TG, TSHR, ICAM1, GNAS, TPO
23amiodarone45 50 29 1113.9TG, TPO, SERPINA7, THRB
24125i4510.9TSHR, SERPINA7, TG, TPO
25glutamate4510.9TPO, GNAS, TRH
26triiodothyroacetic acid4510.9THRB, BGLAP, TG
27hydrocortisone45 2 60 1113.9TG, BGLAP, CALCA, TRH, TPO
28forskolin45 50 1112.9CALCA, NKX2-1, TSHR
29sialic acid4510.9LGALS3, TG, GNAS, TSHR, SERPINA7
30perchlorate4510.9SLC26A4, TPO, TG
31cysteine4510.9TG, TSHR, TPO, GSR, THRB, GNAS
3224,25-dihydroxyvitamin d34510.9CALCA, BGLAP, ADCY10
33h2o24510.9SLC26A4, BGLAP, TPO, LGALS3, ICAM1
34carbimazole45 1111.9BGLAP, TSHR, TPO
35paraffin4510.8LGALS3, BGLAP, NKX2-1, KRT19, TG, TSHR
36clonidine45 29 1112.8ADCY10, TRH, BGLAP, CALCA
37steroid4510.8TPO, SERPINA7, THRB, NKX2-1, IL6R, GNAS
38cycloheximide4510.8TRH, ADCY10
39oligonucleotide4510.8TRH, NKX2-1, IL6R, LGALS3, TSHR, TPO
40estradiol45 11 2412.8TRH, SERPINA7, TSHR
41sodium fluoride4510.7ADCY10, CALCA, BGLAP
42lactate4510.7TG, GSR, LGALS3, KRT19, ICAM1, CALCA
43gnrh4510.7TRH, BGLAP, GNAS, NKX2-1, GSR
44propylthiouracil45 2 1112.7TG
45Liothyronine11 2411.6TPO, SERPINA7, THRB
46serine4510.6NKX2-1, GNAS, BGLAP, KRT19, TSHR, THRB
47thymidine45 2411.6GNAS, TRH, IL6R, KRT19, TSHR, TG
48ascorbic acid45 2411.6ICAM1, BGLAP, TG, TPO, GSR
49chromium4510.4GSR, TG, TPO
50asparagine4510.2GNAS, TPO, TSHR, SERPINA7

GO Terms for genes affiliated with Goiter

Sources:
16Gene Ontology
See all sources

Cellular components related to Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6BGLAP, CALCA, GNAS, TRH, IL6R, SERPINA7
2extracellular spaceGO:00561510.3BGLAP, CALCA, ICAM1, IL6R, SERPINA7, TG

Biological processes related to Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to ethanolGO:04547110.6TRH, ICAM1, BGLAP
2thyroid hormone generationGO:00659010.5TG, TPO
3cAMP biosynthetic processGO:00617110.5ADCY10, GNAS
4response to drugGO:04249310.4BGLAP, GNAS, ICAM1, SERPINA7
5hormone biosynthetic processGO:04244610.2TG, TPO

Molecular functions related to Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1adenylate cyclase activityGO:00401610.5ADCY10, GNAS

Products for genes affiliated with Goiter

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Goiter

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet