Aliases & Classifications for Goiter

MalaCards integrated aliases for Goiter:

Name: Goiter 12 29 52 42 14 69
Goitre 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12176
ICD10 33 E04.9
ICD9CM 35 240.9
MeSH 42 D006042
NCIt 47 C26785
UMLS 69 C0018021

Summaries for Goiter

Disease Ontology : 12 A thyroid gland disease that involves an abnormal enlargement of the thyroid gland.

MalaCards based summary : Goiter, also known as goitre, is related to hyperthyroidism, nonautoimmune and endemic goiter. An important gene associated with Goiter is TG (Thyroglobulin), and among its related pathways/superpathways are Insulin secretion and G alpha (s) signalling events. The drugs Remifentanil and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include thyroid, eye and bone, and related phenotypes are Increased HPV16-GFP infection and endocrine/exocrine gland

Wikipedia : 72 A goitre or goiter is a swelling in the neck resulting from an enlarged thyroid gland. The term is also... more...

Related Diseases for Goiter

Diseases related to Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 253)
id Related Disease Score Top Affiliating Genes
1 hyperthyroidism, nonautoimmune 32.0 GNAS TSHR
2 endemic goiter 31.9 BGLAP CALCA SERPINA7 TG TPO TSHR
3 lymphoma 30.6 TG TPO TSHR
4 thyroid hormone resistance, autosomal recessive 30.3 SERPINA7 THRB TRH TXNRD2
5 hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia 29.0 NKX2-1 PAX8 SERPINA7 SLC26A4 TG TSHR
6 nodular goiter 12.2
7 multinodular goiter 12.2
8 goiter, multinodular 1, with or without sertoli-leydig cell tumors 12.1
9 substernal goiter 12.0
10 nontoxic goiter 12.0
11 pendred syndrome 12.0
12 toxic diffuse goiter 11.9
13 lingual goiter 11.9
14 dyshormonogenic goiter 11.7
15 goiter, multinodular, cystic renal disease, and digital anomalies 11.7
16 graves' disease 11.7
17 deafness goiter stippled epiphyses 11.7
18 daneman davy mancer syndrome 11.5
19 plummer's disease 11.3
20 hypothyroidism 11.1
21 hyperthyroidism 11.1
22 hashimoto thyroiditis 11.0
23 pendred syndrome/dfnb4 10.9
24 bangstad syndrome 10.9
25 maxillary sinus adenoid cystic carcinoma 10.8 TG TPO
26 short stature, microcephaly, and endocrine dysfunction 10.8
27 dicer1-related pleuropulmonary blastoma cancer predisposition syndrome 10.8
28 thyroid dyshormonogenesis 3 10.8
29 chronic polyneuropathy 10.8 TG TSHR
30 thyroiditis 10.8
31 retinal dystrophy with or without extraocular anomalies 10.7
32 thyroid dyshormonogenesis 5 10.7
33 thyroid hormone resistance 10.7
34 familial thyroid dyshormonogenesis 10.7
35 blepharochalasis and double lip 10.7
36 thyroid cancer, anaplastic 10.7
37 central congenital hypothyroidism 10.7
38 thyroid angiosarcoma 10.7
39 thyroid dyshormonogenesis 4 10.7
40 familial hyperthyroidism due to mutations in tsh receptor 10.7
41 thyroid cancer, nonmedullary, 4 10.7
42 myopathy - thyrotoxic 10.7
43 rhabdomyosarcoma, embryonal, 2 10.6 DICER1 TG TPO
44 conjunctival deposit 10.6 TG TPO TSHR
45 tick paralysis 10.6 TG THRB TPO
46 combined cellular and humoral immune defects with granulomas 10.6 TG TPO TSHR
47 atheroembolism of kidney 10.6 TG TRH
48 chronic frontal sinusitis 10.6 TG TPO
49 childhood mediastinal neurogenic tumor 10.6 CALCA TG
50 renal pelvis carcinoma 10.6 GNAS THRB

Comorbidity relations with Goiter via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Hypothyroidism
Nodular Goiter

Graphical network of the top 20 diseases related to Goiter:



Diseases related to Goiter

Symptoms & Phenotypes for Goiter

GenomeRNAi Phenotypes related to Goiter according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased HPV16-GFP infection GR00350-A 8.92 PAX8 SERPINA7 TRH GNAS

MGI Mouse Phenotypes related to Goiter:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.14 DICER1 DUOX2 GNAS NKX2-1 PAX8 SLC26A4
2 homeostasis/metabolism MP:0005376 10.1 DUOX2 GNAS NKX2-1 PAX8 SLC26A4 TG
3 hearing/vestibular/ear MP:0005377 9.91 DUOX2 GNAS PAX8 SLC26A4 THRB TPO
4 nervous system MP:0003631 9.9 DICER1 DUOX2 GNAS NKX2-1 PAX8 SLC26A4
5 craniofacial MP:0005382 9.73 DICER1 GNAS PAX8 THRB
6 limbs/digits/tail MP:0005371 9.73 DICER1 GNAS PAX8 THRB TPO TSHR
7 no phenotypic analysis MP:0003012 9.5 DICER1 GNAS NKX2-1 PAX8 THRB TRH
8 skeleton MP:0005390 9.28 THRB TPO TSHR DICER1 DUOX2 GNAS

Drugs & Therapeutics for Goiter

Drugs for Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 216)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Remifentanil Approved Phase 4 132875-61-7 60815
2
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
4
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
5
Propylthiouracil Approved Phase 4,Phase 3,Phase 2 51-52-5 657298
6
Bimatoprost Approved, Investigational Phase 4,Phase 3 155206-00-1 5311027
7
Latanoprost Approved, Investigational Phase 4 130209-82-4 5282380 5311221
8
Timolol Approved Phase 4 26839-75-8 33624 5478
9
Travoprost Approved Phase 4 157283-68-6 5282226
10
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
11
Acetylcholine Approved Phase 4,Phase 2,Phase 3 51-84-3 187
12
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
13
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
14
Propranolol Approved, Investigational Phase 4 525-66-6 4946
15
Dinoprost Tromethamine Approved, Vet_approved Phase 4 38562-01-5 5282415
16
Ephedrine Approved Phase 4 299-42-3 9294
17
Pseudoephedrine Approved Phase 4 90-82-4 7028
18
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 1 50-02-2 5743
19
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
20
rituximab Approved Phase 4,Phase 2,Phase 3,Phase 1 174722-31-7 10201696
21
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
22
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
23
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
24
Maleic acid Experimental Phase 4 110-16-7 444266
25
Iodine Investigational Phase 4,Phase 2,Phase 3 7553-56-2 807
26
Dinoprost Investigational Phase 4 551-11-1 5283078
27 Autoantibodies Phase 4
28 Analgesics Phase 4,Phase 3,Phase 2
29 Analgesics, Opioid Phase 4
30 Anesthetics Phase 4,Phase 3,Phase 2
31 Anesthetics, General Phase 4
32 Anesthetics, Intravenous Phase 4
33 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
34 Hypnotics and Sedatives Phase 4
35 Narcotics Phase 4
36 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
37 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1
38 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
39 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1
40 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
41 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
42 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1
43 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
44 Hormones Phase 4,Phase 2,Phase 3,Phase 1
45 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
46 Methylprednisolone acetate Phase 4,Phase 2,Phase 3
47 Methylprednisolone Hemisuccinate Phase 4,Phase 2,Phase 3
48 Neuroprotective Agents Phase 4,Phase 2,Phase 3
49 Prednisolone acetate Phase 4,Phase 2,Phase 3
50 Prednisolone hemisuccinate Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 174)

id Name Status NCT ID Phase Drugs
1 The Role of Levothyroxine on Goiter With Atypia of Undetermined Significance Unknown status NCT02329379 Phase 4 Levothyroxine
2 Effect of Higher Doses of Remifentanil on Postoperative Pain in Patients Undergoing Thyroidectomy Unknown status NCT01761149 Phase 4 Remifentanil
3 Total Thyroidectomy With Harmonic Scalpel® Unknown status NCT00385983 Phase 4
4 A Prospective, Randomized Trial of Intravenous Pulse Versus Sequential Steroid Therapy for Patients With Graves' Orbitopathy Unknown status NCT01969019 Phase 4 methylprednisolone, prednisone
5 The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy Unknown status NCT01056419 Phase 4 Propylthiouracil
6 The Secondary Beneficial Effects of Prostaglandin Analog Treatment in Thyroid Eye Disease Patients. Unknown status NCT01927406 Phase 4 Prostaglandin Analog;Timolol
7 LISA-study : Levothyroxin in Nodular Goiter Completed NCT00277589 Phase 4 Levothyroxin-Na;Levothyroxine-Na + iodide;Iodide;Placebo
8 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4 Methimazole
9 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole
10 Is the Routine Pressure Dressing After Thyroidectomy Necessary? Completed NCT00400465 Phase 4
11 Adjuvant Treatment of Graves´ Ophthalmopathy With NSAID (aGO Study) Completed NCT01458600 Phase 4 Diclofenac;Methimazole;L-thyroxin;Propranolol;Metoprolol
12 Impact of SSKI Pre-Treatment on Blood Loss in Thyroidectomy for Graves Disease Completed NCT00946296 Phase 4 Potassium Iodide
13 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4 Bimatoprost;Eye drop solution
14 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
15 Prevention Relapse of Graves' Disease by Intrathyroid Injection of Dexamethasone Completed NCT00917241 Phase 4 MMI combined with IID;MMI
16 Using A Novel Classification System in Intravenous GCs Therapy of TAO: A Multi-central, Randomized, Open, Superior Trial Recruiting NCT03107078 Phase 4 Glucocorticoids
17 Rituximab (RTX) Therapy in Patients With Active TAO Recruiting NCT02378298 Phase 4 Rituximab;Iv Methylprednisolone;peroral methylprednisolone and Methotrexate
18 Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Recruiting NCT01738243 Phase 4 Hyaluronic Acid Gel injection;Saline injection
19 A Trial to Evaluate the Efficacy of Orbital Radiotherapy in Graves' Orbitopathy Not yet recruiting NCT03098225 Phase 4 Methylprednisolone
20 Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease Not yet recruiting NCT02339142 Phase 4 intravenous corticosteroids (methylprednisolone)
21 Effects of Statins in Graves' Orbitopathy (GO) in Hypercholesterolemic Patients Not yet recruiting NCT03110848 Phase 4 Atorvastatin;Methylprednisolone
22 Use of Botox in the Management of Thyroid Related Upper Eyelid Retraction Withdrawn NCT01272414 Phase 4 Botulinum Toxin Type A;Saline injection
23 Laser Therapy of Benign Thyroid Nodules Unknown status NCT00150150 Phase 3
24 Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye Disease Unknown status NCT00370734 Phase 2, Phase 3 Botulinum toxin A injection
25 Treatment of Soft Tissue Expansion in Inactive Thyroid Eye Disease Patients Using Drops of Prostaglandin Analogues Unknown status NCT02155049 Phase 3 bimatoprost 0.03%
26 Prednisone Versus Doxycycline in the Treatment of Graves' Orbitopathy Unknown status NCT01809444 Phase 2, Phase 3 Prednisone+placebo of Doxycycline;Doxycycline+placebo of Prednisone
27 Clinical Trial on Harmonic Focus Shears Completed NCT01003652 Phase 2, Phase 3
28 Efficacy of Ropivacaine (With Epinephrine) in BABA Endoscopic and Robotic Thyroidectomy Completed NCT02112370 Phase 3 Ropivacaine with epinephrine injection
29 Comparison of Different Doses of 131I in Severe Graves' Hyperthyroidism Completed NCT01039818 Phase 3
30 Assessing the Impact of the Early and Systematic Hormonal Replacement After Radio-isotopic Ablation of Graves'hyperthyroïdism on Quality of Life, Efficiency and Tolerance Completed NCT01295333 Phase 3 the early prophylactic introduction of low dose of LT4 (50 µg/d) at 15 days post-ablation;The initiation of LT4 as soon as the first biological signs of hypothyroidism.
31 Trial of Rituximab for Graves' Ophthalmopathy Completed NCT00595335 Phase 2, Phase 3 Rituximab;Saline;Methylprednisolone
32 Tocilizumab Treatment in Graves´ Ophthalmopathy (Graves´ Orbitopathy or Thyroid Eye Disease) Completed NCT01297699 Phase 3 Tocilizumab (RoActemra®);Sterile 0.9% Sodium Chloride
33 Total Thyroidectomy Versus Thionamides in Patients With Moderate-to-Severe Graves' Ophthalmopathy Recruiting NCT03066076 Phase 3 Antithyroid Drug
34 Efficacy and Safety of Cholestyramine and Prednisolone as Adjunctive Therapy in Treatment of Overt Hyperthyroidism Recruiting NCT03303053 Phase 3 Cholestyramine Powder 4g;Prednisolone;Standard treatment
35 Bupivacaine Injection of Eye Muscles to Treat Strabismus Recruiting NCT01616108 Phase 2, Phase 3 Bupivacaine
36 The Effect of Intravenous Glucocorticoids on the Tearfilm in Eyes With Thyroid-associated Ophthalmopathy Recruiting NCT01579539 Phase 3 Methylprednisolone;Esomeprazole
37 Early Levothyroxine Post Radioactive Iodine Active, not recruiting NCT01950260 Phase 2, Phase 3 Levothyroxine
38 Treatment of Graves' Orbitopathy (Thyroid Eye Disease) to Reduce Proptosis With Teprotumumab Infusions in a Randomized, Placebo-Controlled, Clinical Study Not yet recruiting NCT03298867 Phase 3
39 Treatment of Graves´Ophthalmopathy With Diclofenac or Simvastatin (GO-DS) Not yet recruiting NCT03131726 Phase 3 Simvastatin 40mg;Diclofenac Potassium 50 MG
40 The Effect of a New Antioxidant Combination (ASTED) on Moderate to Severe Thyroid Eye Disease Not yet recruiting NCT02422368 Phase 2, Phase 3 Methylprednisolone + ASTED;Methylprednisolone +Placebo
41 The Effect of a New Antioxidant Combination (ASTED) on Mild Thyroid Eye Disease (TED) Not yet recruiting NCT02393183 Phase 2, Phase 3 ASTED
42 Doxycycline Treatment in Mild Graves' Orbitopathy Unknown status NCT02203682 Phase 2 Doxycycline;placebo
43 Role of the Microbiome in Graves' Orbitopathy Unknown status NCT02373995 Phase 1, Phase 2
44 Study to Determine the Dose, the Safety and Effectiveness of a New Drug, Modified Release rhTSH, in Patients With Multinodular Goiter Completed NCT00454220 Phase 2 MRrhTSH;MRrhTSH
45 rhTSH, Radioiodine Uptake and Goiter Reduction Following 131I Therapy in Patients With Benign Nontoxic Nodular Goiter Completed NCT00275171 Phase 2 Recombinant human thyrotropin (Thyrogen);recombinant human TSH
46 rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter Completed NCT00145366 Phase 2 Recombinant human thyrotropin (Thyrogen)
47 Health-Related Quality of Life for Thyroid Patients Completed NCT00150033 Phase 2
48 Efficacy of Subantimicrobial Dose Doxycycline for Moderate to Severe and Active Graves' Orbitopathy Completed NCT01727973 Phase 1, Phase 2 Doxycycline
49 Rituximab in the Treatment of Graves' Disease Completed NCT00150111 Phase 1, Phase 2 Methimazole;Rituximab
50 Effects Of Oral Alfacalcidol On Maturation Of Dendritic Cells In Graves' Disease Patients Completed NCT02993302 Phase 2 1α-D3;Placebos

Search NIH Clinical Center for Goiter

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: goiter

Genetic Tests for Goiter

Genetic tests related to Goiter:

id Genetic test Affiliating Genes
1 Goiter 29

Anatomical Context for Goiter

MalaCards organs/tissues related to Goiter:

39
Thyroid, Eye, Bone, Testes, B Cells, T Cells, Breast

Publications for Goiter

Articles related to Goiter:

(show top 50) (show all 1619)
id Title Authors Year
1
Ten-Year Follow-Up of a Randomized Clinical Trial of Total Thyroidectomy Versus Dunhill Operation Versus Bilateral Subtotal Thyroidectomy for Multinodular Non-toxic Goiter. ( 28942461 )
2017
2
Quality of life after thyroidectomy in patients with nontoxic nodular goiter: A prospective cohort study. ( 28872214 )
2017
3
A case of intravascular large B cell lymphoma presenting as nodular goiter. ( 28841887 )
2017
4
Associations between iodine intake, thyroid volume, and goiter rate in school-aged Chinese children from areas with high iodine drinking water concentrations. ( 27927635 )
2017
5
Chylothorax Associated with Substernal Goiter in Graves' Disease Treated with Radioactive Iodine. ( 28835765 )
2017
6
Role of intraoperative neuromonitoring of the recurrent laryngeal nerves during thyroid reoperations of recurrent goiter. ( 28703113 )
2017
7
Increased Cardiovascular Mortality and Morbidity in Patients Treated for Toxic Nodular Goiter Compared to Graves' Disease and Nontoxic Goiter. ( 28471268 )
2017
8
Multinodular goiter: A study of malignancy risk in nondominant nodules. ( 28846789 )
2017
9
Intra-capsular total thyroid enucleation versus total thyroidectomy in treatment of benign multinodular goiter. A prospective randomized controlled clinical trial. ( 28728986 )
2017
10
Correction: Urinary iodine concentration (UIC) could be a promising biomarker for predicting goiter among school-age children: A systematic review and meta-analysis. ( 28686699 )
2017
11
Comparative Efficacy and Toxicity of Different Species of Sargassum in Haizao Yuhu Decoction in PTU-Induced Goiter Rats. ( 28713435 )
2017
12
Prenatal diagnosis and successful intrauterine treatment of severe congenital hypothyroidism associated with fetal goiter. ( 27862717 )
2017
13
Multinodular goiter in children: treatment controversies. ( 28749783 )
2017
14
Tracheobronchopathia osteochondroplastica in recurrent retrosternal goiter. Surgical management. ( 28904244 )
2017
15
Low Iodine in the Follicular Lumen Caused by Cytoplasm Mis-localization of Sodium Iodide Symporter may Induce Nodular Goiter. ( 28190186 )
2017
16
Simultaneous unilateral anterior thoracoscopy with transcervical thyroidectomy for the resection of large mediastinal thyroid goiter. ( 28932554 )
2017
17
Non-traumatic rupture of the superior thyroid artery with concomitant parathyroid adenoma and multinodular goiter. ( 28811931 )
2017
18
Medical geology of endemic goiter in Kalutara, Sri Lanka; distribution and possible causes. ( 28551882 )
2017
19
Poor dietary diversity, wealth status and use of un-iodized salt are associated with goiter among school children: a cross-sectional study in Ethiopia. ( 28061776 )
2017
20
Frequency of nodular goiter and autoimmune thyroid disease and association of these disorders with insulin resistance in polycystic ovary syndrome. ( 28400351 )
2017
21
Substernal goiter and laryngopharyngeal reflux. ( 28658344 )
2017
22
Correlation between serum lead and thyroid diseases: papillary thyroid carcinoma, nodular goiter, and thyroid adenoma. ( 28891673 )
2017
23
The Value of Preoperative Volumetric Analysis by Computerized Tomography of Retrosternal Goiter to Predict the Need for an Extracervical Approach. ( 28840845 )
2017
24
Symptomatic Long Pauses and Bradycardia due to Massive Multinodular Goiter. ( 28845312 )
2017
25
Myasthenia Gravis, Mediastinal Goiter, and Crohn's Disease. ( 28528037 )
2017
26
Risk Stratification in Multinodular Goiter: A Retrospective Review of Sonographic Features, Histopathological Results, and Cancer Risk. ( 28835334 )
2017
27
Trends in white blood cell and platelet indices in a comparison of patients with papillary thyroid carcinoma and multinodular goiter do not permit differentiation between the conditions. ( 28506088 )
2017
28
Successful combined surgical approach of a rare retrotracheal goiter in a patient with anatomical impediments. ( 28832090 )
2017
29
Increased Chromosomal and Oxidative DNA Damage in Patients with Multinodular Goiter and Their Association with Cancer. ( 28373882 )
2017
30
Higher urinary bisphenol A concentration and excessive iodine intake are associated with nodular goiter and papillary thyroid carcinoma. ( 28684549 )
2017
31
Quantification of Thyroid Cancer and Multinodular Goiter Risk in the DICER1 Syndrome: A Family-Based Cohort Study. ( 28323992 )
2017
32
Giant Cervical Goiter With Posterior Mediastinal Extension. ( 28929034 )
2017
33
The first serological evidence for Rift Valley fever infection in the camel, goitered gazelle and Anatolian water buffaloes in Turkey. ( 28861841 )
2017
34
Patient-tailored management of an asymptomatic massive substernal goiter presenting as brachiocephalic vein occlusion. Report of a case and review of sternotomy indications. ( 28095343 )
2017
35
Multiple Myeloma Presenting as Massive Amyloid Deposition in a Parathyroid Gland Associated with Amyloid Goiter: A Medullary Thyroid Carcinoma Mimic on Intra-operative Frozen Section. ( 28879586 )
2017
36
Neglected nontoxic multinodular goiter presented as a large neck mass. ( 28265406 )
2017
37
Morbidity of total thyroidectomy for substernal goiter: A series of 70 patients. ( 28602544 )
2017
38
A rare case of poorly differentiated thyroid carcinoma probably arising from a nodular goiter. ( 28588422 )
2017
39
Association between single nucleotide variants of vascular endothelial growth factor A and the risk of thyroid carcinoma and nodular goiter in a Han Chinese population. ( 28178662 )
2017
40
A GOITER IN CHRIST IN CRUCIFIXION. ( 27539119 )
2016
41
Genotype-phenotype correlations of dyshormonogenetic goiter in children and adolescents from South India. ( 27867886 )
2016
42
Graves' disease in a mediastinal mass presenting after total thyroidectomy for nontoxic multinodular goiter: a case report. ( 27029843 )
2016
43
Goiter In The Art Of Renaissance Europe. ( 27154774 )
2016
44
Metastasis of Renal Clear Cell Carcinoma to Thyroid Gland Mimicking Adenomatous Goiter. ( 28096905 )
2016
45
Amyloid goiter as the first manifestation of systemic amyloidosis. ( 27525614 )
2016
46
Multinodular goiter with adipose metaplasia: A case report. ( 27772959 )
2016
47
Bilateral benign multinodular goiter: What is the adequate surgical therapy? A review of literature. ( 26708850 )
2016
48
Fetal hypothyroidism induced by maternal anti-TSH receptor blocking antibodies and complicated by polyhydramnios despite the absence of goiter. Treatment by intra-amniotic injections of levothyroxine. ( 27919402 )
2016
49
A Novel Germline Mutation of KEAP1 (R483H) Associated with a Non-Toxic Multinodular Goiter. ( 27703446 )
2016
50
Total Thyroidectomy versus Bilateral Subtotal Thyroidectomy for Bilateral Multinodular Nontoxic Goiter: A Meta-Analysis. ( 27256349 )
2016

Variations for Goiter

Expression for Goiter

Search GEO for disease gene expression data for Goiter.

Pathways for Goiter

GO Terms for Goiter

Biological processes related to Goiter according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.67 DUOX2 IYD TPO TXNRD2
2 positive regulation of cAMP biosynthetic process GO:0030819 9.65 CALCA GNAS TSHR
3 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.63 CALCA GNAS TSHR
4 activation of adenylate cyclase activity GO:0007190 9.61 CALCA GNAS TSHR
5 hydrogen peroxide catabolic process GO:0042744 9.52 DUOX2 TPO
6 positive regulation of adenylate cyclase activity GO:0045762 9.51 CALCA TSHR
7 hormone biosynthetic process GO:0042446 9.5 DUOX2 TG TPO
8 cellular response to gonadotropin stimulus GO:0071371 9.49 PAX8 SLC5A5
9 thyroid hormone metabolic process GO:0042403 9.43 DUOX2 IYD TG
10 thyroid-stimulating hormone signaling pathway GO:0038194 9.4 PAX8 TSHR
11 iodide transport GO:0015705 9.33 SLC26A4 SLC5A5 TG
12 thyroid gland development GO:0030878 9.26 DUOX2 NKX2-1 PAX8 TG
13 thyroid hormone generation GO:0006590 8.92 DUOX2 IYD SLC5A5 TPO

Molecular functions related to Goiter according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.43 CALCA TG TRH
2 peroxidase activity GO:0004601 9.32 DUOX2 TPO
3 iodide transmembrane transporter activity GO:0015111 9.16 SLC26A4 SLC5A5
4 iodide peroxidase activity GO:0004447 8.96 IYD TPO
5 thyroid-stimulating hormone receptor activity GO:0004996 8.62 PAX8 TSHR

Sources for Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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