MCID: GTR002
MIFTS: 61

Goiter malady

Summaries for Goiter

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 A goitre or goiter (Latin gutteria, struma), is a swelling of the neck or larynx resulting from... more...

MalaCards: Goiter is related to thyroiditis and endemic goiter. An important gene associated with Goiter is TG (thyroglobulin), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Allograft rejection. The drugs methimazole and propylthiouracil and the compounds tyrosine and arginine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and bone, and related mouse phenotypes are homeostasis/metabolism and nervous system.

Disease Ontology:8 A thyroid gland disease that involves an abnormal enlargement of the thyroid gland.

Aliases & Classifications for Goiter

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM
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Aliases & Descriptions:

goiter 8 10 44 60


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Disease Ontology8 DOID:12176
MeSH34 D006042
NCIt39 C26785
ICD9CM27 240.9

Related Diseases for Goiter

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17GeneCards, 18GeneDecks
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Diseases in the Goiter family:

Goiter, Familial, Due to Ttf-1 Defect

Diseases related to Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 251)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.6TG, TPO, CALCA, TRH, SERPINA7, TSHR
2endemic goiter31.6TSHR, TPO, TG
3multinodular goiter31.5SLC26A4, KRT19, TSHR, ADCY10, TPO, TG
4nodular goiter31.5TPO, TG, TSHR, LGALS3, KRT19, CALCA
5nontoxic goiter31.2BGLAP, TSHR, TPO, TG
6hypothyroidism31.0NKX2-1, TRH, SLC26A4, TSHR, TPO, TG
7graves' disease31.0TSHR, GNAS
8thyroid cancer30.9CALCA, GNAS, NKX2-1, TRH, THRB, SLC26A4
9hyperthyroidism30.9TPO, TG, ADCY10, TSHR, SERPINA7, BGLAP
10toxic diffuse goiter30.9TSHR, TPO, TG
11adenoma30.7CALCA, GNAS, NKX2-1, TRH, IL6R, THRB
12papillary carcinoma30.7TG, TPO, CALCA, GNAS, NKX2-1, SLC26A4
13pendred syndrome30.7SLC26A4, TPO, TG
14papillary thyroid carcinoma30.7TG, TPO, TSHR, LGALS3
15thyrotoxicosis30.6TRH, THRB, SERPINA7, TSHR, TPO, TG
16congenital hypothyroidism30.6GNAS, NKX2-1, SERPINA7, TSHR, TPO, TG
17autoimmune thyroiditis30.6CALCA, TPO, TG
18hyperparathyroidism30.5ADCY10, CALCA, BGLAP
19plummer's disease30.5TG, TPO, ICAM1
20follicular thyroid carcinoma30.4CALCA, THRB, TSHR, ADCY10, TG
21parathyroid adenoma30.3LGALS3, GNAS, CALCA
22thyroid medullary carcinoma30.2CALCA, NKX2-1, LGALS3, TG
23myxedema30.1TSHR, TPO, TG
24acromegaly30.0ADCY10, TRH, GNAS, BGLAP
25follicular adenoma30.0KRT19, LGALS3
26arthritis30.0IL6R, ICAM1, CALCA, BGLAP
27rheumatoid arthritis30.0IL6R, ICAM1, BGLAP
28thymoma29.9NKX2-1
29mccune albright syndrome29.9GNAS
30leydig cell tumor29.9ADCY10, GNAS
31breast cancer29.7CALCA, IL6R, THRB, KRT19, LGALS3, ADCY10
32hyperthyroxinemia29.7TRH, SERPINA7, TSHR, TPO
33thyroid hormone resistance syndrome29.7TRH, THRB, SERPINA7, TG
34obesity29.7GNAS, TRH, IL6R, ADCY10
35subacute thyroiditis29.7TPO, TSHR, TG
36melanoma29.7TSHR, LGALS3, NKX2-1, ICAM1
37struma ovarii29.7NKX2-1, TSHR, TG
38paraganglioma29.7TG, CALCA
39pancreatitis29.7ICAM1
40lung cancer29.7KRT19, NKX2-1
41fibrous dysplasia29.7BGLAP, GNAS, ADCY10
42adenocarcinoma29.7ADCY10, LGALS3, KRT19, NKX2-1
43hypoparathyroidism29.7CALCA, BGLAP
44addison's disease29.7TPO, TG
45tuberculosis29.7GSR, TPO, ADCY10
46myocardial infarction29.7IL6R, TPO, GSR
47amenorrhea29.7TRH
48ischemia29.7ICAM1, IL6R, LGALS3, GSR
49substernal goiter10.7
50mediastinitis10.5

Graphical network of the top 20 diseases related to Goiter:



Diseases related to goiter

Clinical Features for Goiter

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Drugs & Therapeutics for Goiter

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Goiter

Drug clinical trials:

Search ClinicalTrials for Goiter

Search NIH Clinical Center for Goiter

Search CenterWatch for Goiter

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Goiter

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Anatomical Context for Goiter

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32MalaCards
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MalaCards organs/tissues related to Goiter:

32
Thyroid, Testes, Bone, Pituitary, Trachea, Breast, Endothelial, Kidney, Heart, T cells, Cortex, Colon, Lymph node, Lung, Tonsil, Salivary gland, Whole blood

Animal Models for Goiter or affiliated genes

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36MGI
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Publications for Goiter

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50PubMed
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Articles related to Goiter:

(show top 50)    (show all 1408)
idTitleAuthorsYear
1
Primary amyloid goiter mimicking rapid growing thyroid malignancy. (24150545)
2014
2
Expression of estrogen and progesterone receptors and Ki-67 antigen in Graves' disease and nodular goiter. (23907943)
2013
3
Non toxic goiter in the adult population of Genoa: 10 years of experience. (22803312)
2012
4
The onset of goiter in several species of sharks following the addition of ozone to a touch pool. (23082528)
2012
5
DUOX2 gene mutation in patients with congenital goiter with hypothyroidism]. (22336364)
2011
6
The surgical management of goiter: Part I. Preoperative evaluation. (21132771)
2011
7
Endocrinology and art. A noblewoman with goiter - Ritratto di gentildonna Prospero Fontana (1512-1597). (22156909)
2011
8
Mediastinal extension of a goiter. (21630617)
2011
9
Image in endocrinology. Pemberton's sign in patient with substernal goiter. (20823469)
2010
10
Imaging of ectopic intrathoracic multinodular goiter with pathologic correlation: a case report. (19830083)
2009
11
Etiology of simple goiter. (19265491)
2009
12
What constitutes adequate surgical therapy for benign nodular goiter? (18952235)
2009
13
Congenital hypothyroidism and late-onset goiter: identification and characterization of a novel mutation in the sodium/iodide symporter of the proband and family members. (19916865)
2009
14
Harmonic scalpel in multinodular goiter surgery: impact on surgery and cost analysis. (19260785)
2009
15
No link between X chromosome inactivation pattern and simple goiter in females: evidence from a twin study. (19191747)
2009
16
Results of surgical treatment in multinodular goiter with an intrathoracic component. (18516526)
2008
17
High prevalence of goiter in an iodine replete area: do thyroid auto-antibodies play a role? (17704020)
2007
18
LOCALIZATION OF A PARATHYROID ADENOMA IN A MULTI-NODULAR GOITER USING SESTAMIBI AND Tc-99m PERTECHNETATE SCANS. (18070589)
2007
19
Symptomatic benign multinodular goiter: unilateral or bilateral thyroidectomy? (17950336)
2007
20
Three mutations (p.Q36H, p.G418fsX482, and g.IVS19-2A-->C) in the dual oxidase 2 gene responsible for congenital goiter and iodide organification defect. (16322276)
2006
21
Further indications for genetic heterogeneity of euthyroid familial goiter. (14564411)
2003
22
Fluorine-18-fluorodeoxyglucose positron emission tomography in the preoperative assessment of thyroid nodules in an endemic goiter area. (12660642)
2003
23
Lack of reported mutations in a Japanese case of toxic multinodular goiter. (12232474)
2002
24
Evaluation and treatment of sporadic nontoxic goiter--some answers and more questions. (11238475)
2001
25
Nodular goiter and goiter nodules: Where iodine deficiency falls short of explaining the facts. (11507648)
2001
26
Activin A and activin receptors in the human thyroid: a link to the female predominance of goiter? (11069203)
2000
27
Iodine and zinc, but not selenium and copper, deficiency exists in a male Turkish population with endemic goiter. (10468158)
1999
28
Mutations in the thyrotropin receptor gene in the pathogenesis of toxic thyroid adenomas, toxic goiter nodules and autosomal dominant hyperthyroidism]. (10355046)
1999
29
Bilateral recurrent nerve paralysis associated with multinodular substernal goiter: a case report. (10231217)
1999
30
Diagnosis and radioablation treatment of toxic multinodular goiter in a hemodialysis patient. (9531189)
1998
31
Radioiodine for nontoxic multinodular goiter. (9133693)
1997
32
Paraganglioma-Like Adenomas of the Thyroid (PLAT): Incidental Lesions with Unusual Features in a Patient with Nodular Goiter. (12114635)
1997
33
Treatment with triiodothyronine (T3) against multinodular goiter fails to prevent the onset of Graves' disease. (10993976)
1995
34
Serum selenium concentrations in patients with autoimmune thyroiditis and non-toxic nodular goiter. (7508739)
1993
35
Scintigraphic demonstration of sequestered nodular goiter. A lateral aberrant thyroid rest. (1587049)
1992
36
Limited value of delayed radiothallium image in the diagnosis of nodular goiter. (1777352)
1991
37
Interrelationships between age, thyroid volume, thyroid nodularity, and thyroid function in patients with sporadic nontoxic goiter. (2239979)
1990
38
Iodine-123 SPECT of the thyroid in multinodular goiter. (3257257)
1988
39
Total thyroidectomy: the preferred option for multinodular goiter. (3401066)
1988
40
Comparison of serum angiotensin-converting enzyme in Graves' disease, toxic nodular goiter, and other thyroid conditions. (2989614)
1985
41
Simultaneous treatment of toxic diffuse goiter with I-131 and antithyroid drugs: a prospective study. (94089)
1979
42
Evidence that cassava ingestion increases thiocyanate formation: a possible etiologic factor in endemic goiter. (755045)
1978
43
Iodine metabolism in endemic goiter in Turkey. I. The kinetics of 131-I and organic iodine. (4125988)
1973
44
Endemic goiter prevention by iodized oil: a reassessment. (4350351)
1973
45
Endemic goiter with hypothyroidism in three generations. (5347689)
1969
46
A study on biosynthesis of iodoamino acids in the nodule and paranodular thyroid tissue in nontoxic nodular goiter with special reference to the application of paper chromatographic analysis using Na-I-131. (5913196)
1966
47
DYNAMIC DISTURBANCES OF INTRATHYROID IODINE METABOLISM IN SPORADIC NONTOXIC GOITER. (14167072)
1964
48
RECURRENT BENIGN NODULAR GOITER IN CHILDREN. (14083591)
1963
49
A chromatographic study of thyroidal iodine metabolism in nontoxic nodular goiter. (13475471)
1957
50
Carcinoma in nodular goiter. (13356592)
1956

Genetic Variations for Goiter

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Expression for genes affiliated with Goiter

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Goiter

Search GEO for disease gene expression data for Goiter.

Pathways for genes affiliated with Goiter

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53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Goiter according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6TSHR, THRB, TRH, GNAS, CALCA
2
Hide members
10.5TSHR, TPO, TG
3
Hide members
10.5TG, GSR, TPO
410.5ADCY10, GNAS, CALCA
5
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.5THRB, CALCA, BGLAP

Compounds for genes affiliated with Goiter

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44Novoseek, 24HMDB, 2BitterDB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB
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Compounds related to Goiter according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.1THRB, SLC26A4, KRT19, LGALS3, SERPINA7, TSHR
2arginine4411.1IL6R, BGLAP, ADCY10, TSHR, SERPINA7, LGALS3
3thyroxine44 2412.1BGLAP, CALCA, TRH, THRB, TG, GSR
4ribonucleic acid4411.1THRB, IL6R, NKX2-1, GNAS, KRT19, SERPINA7
5iodine44 2412.0TPO, TSHR, SERPINA7, TG, GNAS, TRH
6methimazole44 2 1113.0GSR, BGLAP, ICAM1, TRH, SERPINA7, TSHR
7retinoic acid44 2412.0TSHR, TPO, TG, THRB, LGALS3, IL6R
8triiodothyronine4411.0TPO, TSHR, TG, SERPINA7, SLC26A4, THRB
9guanine44 11 2413.0ICAM1, THRB, TSHR, ADCY10, TG, CALCA
10progesterone44 59 28 11 2415.0TSHR, TRH, NKX2-1, KRT19, SERPINA7, LGALS3
11testosterone44 59 11 2414.0TG, IL6R, TPO, SERPINA7, KRT19, THRB
12adenylate4411.0CALCA, ADCY10, TPO, GSR, TG, GNAS
13sodium iodide4411.0NKX2-1, SLC26A4, TPO, TSHR, TG
14iodide44 2412.0SERPINA7, SLC26A4, TG, NKX2-1, TPO
15acth4411.0TRH, LGALS3, TPO, SERPINA7, TSHR, GNAS
16creatinine4411.0GSR, TPO, IL6R, KRT19, BGLAP, TG
17estrogen4411.0TRH, TG, TSHR, SERPINA7
18vegf4411.0TSHR, KRT19, LGALS3, IL6R, ICAM1, BGLAP
19octreotide44 59 28 1114.0TG, ADCY10, TRH, GNAS, CALCA
20alanine4411.0GSR, THRB, TSHR, SERPINA7, LGALS3, GNAS
21aspartate4410.9TSHR, SERPINA7, KRT19, BGLAP, TPO, GSR
22polysaccharide4410.9LGALS3, TG, TSHR, ICAM1, GNAS, TPO
23amiodarone44 49 28 1113.9TG, TPO, SERPINA7, THRB
24125i4410.9TSHR, SERPINA7, TG, TPO
25glutamate4410.9TPO, GNAS, TRH
26triiodothyroacetic acid4410.9THRB, BGLAP, TG
27hydrocortisone44 2 59 1113.9TG, BGLAP, CALCA, TRH, TPO
28forskolin44 49 1112.9CALCA, NKX2-1, TSHR
29sialic acid4410.9LGALS3, TG, GNAS, TSHR, SERPINA7
30perchlorate4410.9SLC26A4, TPO, TG
31cysteine4410.9TG, TSHR, TPO, GSR, THRB, GNAS
3224,25-dihydroxyvitamin d34410.9CALCA, BGLAP, ADCY10
33h2o24410.9SLC26A4, BGLAP, TPO, LGALS3, ICAM1
34carbimazole44 1111.9BGLAP, TSHR, TPO
35paraffin4410.8LGALS3, BGLAP, NKX2-1, KRT19, TG, TSHR
36clonidine44 28 1112.8ADCY10, TRH, BGLAP, CALCA
37steroid4410.8TPO, SERPINA7, THRB, NKX2-1, IL6R, GNAS
38cycloheximide4410.8TRH, ADCY10
39oligonucleotide4410.8TRH, NKX2-1, IL6R, LGALS3, TSHR, TPO
40estradiol44 11 2412.8TRH, SERPINA7, TSHR
41sodium fluoride4410.7ADCY10, CALCA, BGLAP
42lactate4410.7TG, GSR, LGALS3, KRT19, ICAM1, CALCA
43gnrh4410.7TRH, BGLAP, GNAS, NKX2-1, GSR
44propylthiouracil44 2 1112.7TG
45Liothyronine11 2411.6TPO, SERPINA7, THRB
46serine4410.6NKX2-1, GNAS, BGLAP, KRT19, TSHR, THRB
47thymidine44 2411.6GNAS, TRH, IL6R, KRT19, TSHR, TG
48ascorbic acid44 2411.6ICAM1, BGLAP, TG, TPO, GSR
49chromium4410.4GSR, TG, TPO
50asparagine4410.2GNAS, TPO, TSHR, SERPINA7

GO Terms for genes affiliated with Goiter

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16Gene Ontology
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Cellular components related to Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6CALCA, GNAS, TRH, IL6R, SERPINA7, TG
2extracellular spaceGO:00561510.3TG, SERPINA7, IL6R, ICAM1, CALCA, BGLAP

Biological processes related to Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to ethanolGO:04547110.6TRH, ICAM1, BGLAP
2thyroid hormone generationGO:00659010.5TG, TPO
3cAMP biosynthetic processGO:00617110.5ADCY10, GNAS
4response to drugGO:04249310.4BGLAP, GNAS, ICAM1, SERPINA7
5hormone biosynthetic processGO:04244610.2TG, TPO

Molecular functions related to Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1adenylate cyclase activityGO:00401610.5ADCY10, GNAS

Products for genes affiliated with Goiter

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  • Antibodies
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Sources for Goiter

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet