MCID: GTR002
MIFTS: 61

Goiter malady

Summaries for Goiter

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 A goitre or goiter (Latin gutteria, struma), is a swelling of the neck or larynx resulting from... more...

MalaCards: Goiter is related to thyroiditis and endemic goiter. An important gene associated with Goiter is TG (thyroglobulin), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Allograft rejection. The drugs methimazole and propylthiouracil and the compounds tyrosine and arginine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and bone, and related mouse phenotypes are homeostasis/metabolism and nervous system.

Disease Ontology:8 A thyroid gland disease that involves an abnormal enlargement of the thyroid gland.

Aliases & Classifications for Goiter

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM
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Aliases & Descriptions:

goiter 8 10 44 60


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Disease Ontology8 DOID:12176
MeSH34 D006042
NCIt39 C26785
ICD9CM27 240.9

Related Diseases for Goiter

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17GeneCards, 18GeneDecks
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Diseases in the Goiter family:

Goiter, Familial, Due to Ttf-1 Defect

Diseases related to Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 251)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.6TG, TPO, CALCA, TRH, SERPINA7, TSHR
2endemic goiter31.6TSHR, TPO, TG
3multinodular goiter31.5SLC26A4, KRT19, TSHR, ADCY10, TPO, TG
4nodular goiter31.5TPO, TG, TSHR, LGALS3, KRT19, CALCA
5nontoxic goiter31.2BGLAP, TSHR, TPO, TG
6hypothyroidism31.0NKX2-1, TRH, SLC26A4, TSHR, TPO, TG
7graves' disease31.0TSHR, GNAS
8thyroid cancer30.9CALCA, GNAS, NKX2-1, TRH, THRB, SLC26A4
9hyperthyroidism30.9TPO, TG, ADCY10, TSHR, SERPINA7, BGLAP
10toxic diffuse goiter30.9TSHR, TPO, TG
11adenoma30.7CALCA, GNAS, NKX2-1, TRH, IL6R, THRB
12papillary carcinoma30.7TG, TPO, CALCA, GNAS, NKX2-1, SLC26A4
13pendred syndrome30.7SLC26A4, TPO, TG
14papillary thyroid carcinoma30.7TG, TPO, TSHR, LGALS3
15thyrotoxicosis30.6TRH, THRB, SERPINA7, TSHR, TPO, TG
16congenital hypothyroidism30.6GNAS, NKX2-1, SERPINA7, TSHR, TPO, TG
17autoimmune thyroiditis30.6CALCA, TPO, TG
18hyperparathyroidism30.5ADCY10, CALCA, BGLAP
19plummer's disease30.5TG, TPO, ICAM1
20follicular thyroid carcinoma30.4CALCA, THRB, TSHR, ADCY10, TG
21parathyroid adenoma30.3LGALS3, GNAS, CALCA
22thyroid medullary carcinoma30.2CALCA, NKX2-1, LGALS3, TG
23myxedema30.1TSHR, TPO, TG
24acromegaly30.0ADCY10, TRH, GNAS, BGLAP
25follicular adenoma30.0KRT19, LGALS3
26arthritis30.0IL6R, ICAM1, CALCA, BGLAP
27rheumatoid arthritis30.0IL6R, ICAM1, BGLAP
28thymoma29.9NKX2-1
29mccune albright syndrome29.9GNAS
30leydig cell tumor29.9ADCY10, GNAS
31breast cancer29.7CALCA, IL6R, THRB, KRT19, LGALS3, ADCY10
32hyperthyroxinemia29.7TRH, SERPINA7, TSHR, TPO
33thyroid hormone resistance syndrome29.7TRH, THRB, SERPINA7, TG
34obesity29.7GNAS, TRH, IL6R, ADCY10
35subacute thyroiditis29.7TPO, TSHR, TG
36melanoma29.7TSHR, LGALS3, NKX2-1, ICAM1
37struma ovarii29.7NKX2-1, TSHR, TG
38paraganglioma29.7TG, CALCA
39pancreatitis29.7ICAM1
40lung cancer29.7KRT19, NKX2-1
41fibrous dysplasia29.7BGLAP, GNAS, ADCY10
42adenocarcinoma29.7ADCY10, LGALS3, KRT19, NKX2-1
43hypoparathyroidism29.7CALCA, BGLAP
44addison's disease29.7TPO, TG
45tuberculosis29.7GSR, TPO, ADCY10
46myocardial infarction29.7IL6R, TPO, GSR
47amenorrhea29.7TRH
48ischemia29.7ICAM1, IL6R, LGALS3, GSR
49substernal goiter10.7
50mediastinitis10.5

Graphical network of the top 20 diseases related to Goiter:



Diseases related to goiter

Clinical Features for Goiter

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Drugs & Therapeutics for Goiter

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Goiter

Drug clinical trials:

Search ClinicalTrials for Goiter

Search NIH Clinical Center for Goiter

Search CenterWatch for Goiter

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Goiter

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Anatomical Context for Goiter

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32MalaCards
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MalaCards organs/tissues related to Goiter:

32
Thyroid, Testes, Bone, Pituitary, Trachea, Breast, Endothelial, Kidney, Heart, T cells, Cortex, Colon, Lymph node, Lung, Tonsil, Salivary gland, Whole blood

Animal Models for Goiter or affiliated genes

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36MGI
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Publications for Goiter

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50PubMed
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Articles related to Goiter:

(show top 50)    (show all 1408)
idTitleAuthorsYear
1
Effect of 1110 MBq Radioiodine in Reducing Thyroid Volume in Multinodular Goiter: A New Protocol. (23671549)
2013
2
Thyroid function: cause of increased mortality differs for Graves disease and toxic nodular goiter. (23318229)
2013
3
Total Thyroidectomy for Multinodular Goiter. Possibility of Implementation in aA District Hospital. (23585205)
2013
4
Retrosternal goiter: the need for thoracic approach based on CT findings: surgeon's view. (23582600)
2012
5
Differential expression patterns of estrogen receptor (ER)-I^ splice variants between papillary thyroid cancer and nodular thyroid goiter. (22936184)
2012
6
Goiter with vascular anomalies in a litter of Polish Lowland sheepdogs. (22611215)
2012
7
Comment on "Intrauterine diagnosis and management of fetal goiter: a case report". (21469148)
2011
8
Endemic goiter--individual risk factors necessitate individual treatment. (22006052)
2011
9
Amyloid goiter and hypopituitarism in a patient with systemic amyloidosis. (21231858)
2011
10
The surgical management of goiter: Part II. Surgical treatment and results. (21154775)
2011
11
Preoperative multidisciplinary management of airway obstruction by huge goiter with papillary thyroid cancer. (21679579)
2011
12
Papillary thyroid microcarcinoma: extrathyroidal extension, lymph node metastases, and risk factors for recurrence in a high prevalence of goiter area. (20052467)
2010
13
Genetics and phenomics of hypothyroidism and goiter due to TPO mutations. (20153806)
2010
14
Goiter be gone. How is a goiter treated? (20736905)
2010
15
Amyloid goiter. (19937940)
2010
16
Biochemical changes during goiter induction by methylmercaptoimidazol and inhibition by delta-iodolactone in rat. (20825298)
2010
17
The role of thyroid autoantibodies in the etiology of endemic goiter in schoolchildren of Isfahan, Iran. (19494708)
2009
18
Lateral cervical ectopic thyroid masses with eutopic multinodular goiter: an unusual presentation. (19570743)
2009
19
Radioiodine therapy for multinodular goiter. (22964127)
2008
20
The many reasons why goiter is seen in old paintings. (18399764)
2008
21
Management of multinodular goiter in Germany (Papillon 2005): do the approaches of thyroid specialists and primary care practitioners differ? (17549317)
2007
22
Value of repeated fine needle aspiration cytology in patients with nodular goiter. (18077975)
2007
23
The advantage of near-total thyroidectomy to avoid postoperative hypoparathyroidism in benign multinodular goiter. (17021791)
2006
24
Autoimmunization and multinodular large toxic goiter therapy using repeated doses of 131I]. (17263226)
2006
25
Thyroid MALT lymphoma in patients with a compressive goiter. (16628752)
2006
26
Multinodular goiter: surgical management and histopathological findings. (12064511)
2002
27
Non-hyperfunctioning nodules from multinodular goiters: a minor role in pathogenesis for somatic activating mutations in the TSH-receptor and Gsalpha subunit genes. (11407651)
2001
28
Surgical management of substernal goiter. (11155771)
2000
29
Intrathoracic retroesophageal goiter causing tracheal stenosis. (10358949)
1999
30
Concurrence of Pendred syndrome, autoimmune thyroiditis, and simple goiter in one family. (10443670)
1999
31
Upregulation of the angiogenic factors PlGF, VEGF and their receptors (Flt-1, Flk-1/KDR) by TSH in cultured thyrocytes and in the thyroid gland of thiouracil-fed rats suggest a TSH-dependent paracrine mechanism for goiter hypervascularization. (9400995)
1997
32
Large parathyroid functioning carcinoma (1,200 g) presenting as a substernal goiter. (1560189)
1992
33
Enhanced iodine concentrating capacity by the mammary gland in iodine deficient lactating women of an endemic goiter region in Sicily. (1569290)
1992
34
Clinicopathologic management of tumors of the thyroid gland in an endemic goiter area. Combined use of preoperative fine needle aspiration biopsy and intraoperative frozen section. (2916368)
1989
35
Effect of therapy on the serum thyroglobulin concentration in patients with toxic diffuse goiter, toxic nodular goiter and toxic adenoma. (2445808)
1987
36
Surgery of substernal goiter. (3331229)
1987
37
Pilot study to detect neurologic disease in Ecuador among a population with a high prevalence of endemic goiter. (3831782)
1985
38
Cyclic AMP in non-toxic nodular goiter. (6254754)
1980
39
Iodide organification defect in iodine deficiency endemic goiter. (263314)
1978
40
Serum triiodothyronine in simple nontoxic goiter in Sicily. (1213666)
1975
41
Endemic goiter in Greece: nutritional status, growth, and skeletal development of goitrous and non goitrous populations. (4357119)
1973
42
Circulating thyroid hormones in endemic goiter. (5012499)
1972
43
Characteristics of thyroid scans in normal persons, hyperthyroidism and nodular goiter. (5638627)
1968
44
A consideration of the proper surgical approach for substernal goiter. (14408062)
1960
45
Correlation of goiter, deafmutism and mental retardation with serum thyroid hormone levels in noncretinous inhabitants of a severe endemic goiter area in India. (13620749)
1959
46
Treatment of a lingual goiter with triiodothyronine. (13631053)
1959
47
Nodular goiter; etiology, treatment and incidence of carcinoma. (13504570)
1958
48
Correlation of hypercementosis with toxic goiter; a preliminary report. (14888775)
1951
49
Long survival of a patient with cerebellar medulloblastoma and malignant goiter treated by roentgen therapy; report of a case. (20280905)
1947
50
Nodular goiter and cancer of the thyroid. (20293165)
1947

Genetic Variations for Goiter

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Expression for genes affiliated with Goiter

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Goiter

Search GEO for disease gene expression data for Goiter.

Pathways for genes affiliated with Goiter

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53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Goiter according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6TSHR, THRB, TRH, GNAS, CALCA
2
Hide members
10.5TSHR, TPO, TG
3
Hide members
10.5TG, GSR, TPO
410.5ADCY10, GNAS, CALCA
5
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.5THRB, CALCA, BGLAP

Compounds for genes affiliated with Goiter

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44Novoseek, 24HMDB, 2BitterDB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB
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Compounds related to Goiter according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.1THRB, SLC26A4, KRT19, LGALS3, SERPINA7, TSHR
2arginine4411.1IL6R, BGLAP, ADCY10, TSHR, SERPINA7, LGALS3
3thyroxine44 2412.1BGLAP, CALCA, TRH, THRB, TG, GSR
4ribonucleic acid4411.1THRB, IL6R, NKX2-1, GNAS, KRT19, SERPINA7
5iodine44 2412.0TPO, TSHR, SERPINA7, TG, GNAS, TRH
6methimazole44 2 1113.0GSR, BGLAP, ICAM1, TRH, SERPINA7, TSHR
7retinoic acid44 2412.0TSHR, TPO, TG, THRB, LGALS3, IL6R
8triiodothyronine4411.0TPO, TSHR, TG, SERPINA7, SLC26A4, THRB
9guanine44 11 2413.0ICAM1, THRB, TSHR, ADCY10, TG, CALCA
10progesterone44 59 28 11 2415.0TSHR, TRH, NKX2-1, KRT19, SERPINA7, LGALS3
11testosterone44 59 11 2414.0TG, IL6R, TPO, SERPINA7, KRT19, THRB
12adenylate4411.0CALCA, ADCY10, TPO, GSR, TG, GNAS
13sodium iodide4411.0NKX2-1, SLC26A4, TPO, TSHR, TG
14iodide44 2412.0SERPINA7, SLC26A4, TG, NKX2-1, TPO
15acth4411.0TRH, LGALS3, TPO, SERPINA7, TSHR, GNAS
16creatinine4411.0GSR, TPO, IL6R, KRT19, BGLAP, TG
17estrogen4411.0TRH, TG, TSHR, SERPINA7
18vegf4411.0TSHR, KRT19, LGALS3, IL6R, ICAM1, BGLAP
19octreotide44 59 28 1114.0TG, ADCY10, TRH, GNAS, CALCA
20alanine4411.0GSR, THRB, TSHR, SERPINA7, LGALS3, GNAS
21aspartate4410.9TSHR, SERPINA7, KRT19, BGLAP, TPO, GSR
22polysaccharide4410.9LGALS3, TG, TSHR, ICAM1, GNAS, TPO
23amiodarone44 49 28 1113.9TG, TPO, SERPINA7, THRB
24125i4410.9TSHR, SERPINA7, TG, TPO
25glutamate4410.9TPO, GNAS, TRH
26triiodothyroacetic acid4410.9THRB, BGLAP, TG
27hydrocortisone44 2 59 1113.9TG, BGLAP, CALCA, TRH, TPO
28forskolin44 49 1112.9CALCA, NKX2-1, TSHR
29sialic acid4410.9LGALS3, TG, GNAS, TSHR, SERPINA7
30perchlorate4410.9SLC26A4, TPO, TG
31cysteine4410.9TG, TSHR, TPO, GSR, THRB, GNAS
3224,25-dihydroxyvitamin d34410.9CALCA, BGLAP, ADCY10
33h2o24410.9SLC26A4, BGLAP, TPO, LGALS3, ICAM1
34carbimazole44 1111.9BGLAP, TSHR, TPO
35paraffin4410.8LGALS3, BGLAP, NKX2-1, KRT19, TG, TSHR
36clonidine44 28 1112.8ADCY10, TRH, BGLAP, CALCA
37steroid4410.8TPO, SERPINA7, THRB, NKX2-1, IL6R, GNAS
38cycloheximide4410.8TRH, ADCY10
39oligonucleotide4410.8TRH, NKX2-1, IL6R, LGALS3, TSHR, TPO
40estradiol44 11 2412.8TRH, SERPINA7, TSHR
41sodium fluoride4410.7ADCY10, CALCA, BGLAP
42lactate4410.7TG, GSR, LGALS3, KRT19, ICAM1, CALCA
43gnrh4410.7TRH, BGLAP, GNAS, NKX2-1, GSR
44propylthiouracil44 2 1112.7TG
45Liothyronine11 2411.6TPO, SERPINA7, THRB
46serine4410.6NKX2-1, GNAS, BGLAP, KRT19, TSHR, THRB
47thymidine44 2411.6GNAS, TRH, IL6R, KRT19, TSHR, TG
48ascorbic acid44 2411.6ICAM1, BGLAP, TG, TPO, GSR
49chromium4410.4GSR, TG, TPO
50asparagine4410.2GNAS, TPO, TSHR, SERPINA7

GO Terms for genes affiliated with Goiter

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16Gene Ontology
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Cellular components related to Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6CALCA, GNAS, TRH, IL6R, SERPINA7, TG
2extracellular spaceGO:00561510.3TG, SERPINA7, IL6R, ICAM1, CALCA, BGLAP

Biological processes related to Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to ethanolGO:04547110.6TRH, ICAM1, BGLAP
2thyroid hormone generationGO:00659010.5TG, TPO
3cAMP biosynthetic processGO:00617110.5ADCY10, GNAS
4response to drugGO:04249310.4BGLAP, GNAS, ICAM1, SERPINA7
5hormone biosynthetic processGO:04244610.2TG, TPO

Molecular functions related to Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1adenylate cyclase activityGO:00401610.5ADCY10, GNAS

Products for genes affiliated with Goiter

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  • Antibodies
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Sources for Goiter

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet