MCID: GTR002
MIFTS: 62

Goiter malady

Genetic diseases (common), Endocrine diseases categories

Summaries for Goiter

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Wikipedia:66 A goitre or goiter (Latin gutteria, struma), is a swelling of the neck or larynx resulting from... more...

MalaCards: Goiter is related to endemic goiter and thyroiditis. An important gene associated with Goiter is TG (thyroglobulin), and among its related pathways are Endothelin and Adenylate cyclase activating neuropeptides. The drugs methimazole and propylthiouracil and the compounds iodotyrosine and diiodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and testes, and related mouse phenotypes are tumorigenesis and limbs/digits/tail.

Disease Ontology:9 A thyroid gland disease that involves an abnormal enlargement of the thyroid gland.

Aliases & Classifications for Goiter

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 28ICD9CM, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Endocrine diseases


Aliases & Descriptions:

goiter 9 11 46 63


External Ids:

Disease Ontology9 DOID:12176
ICD9CM28 240.9
NCIt41 C26785
MeSH36 D006042

Related Diseases for Goiter

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18GeneCards, 19GeneDecks
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Diseases in the Goiter family:

Goiter, Familial, Due to Ttf-1 Defect

Diseases related to Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 207)
idRelated DiseaseScoreTop Affiliating Genes
1endemic goiter31.8TPO, TG, TSHR
2thyroiditis31.7TPO, TG, TSHR, CALCA
3nodular goiter31.5TPO, TG, TSHR, LGALS3, CALCA
4multinodular goiter31.5SLC26A4, CALCA, TSHR, TG, TPO, GNAS
5graves' disease31.2TSHR, GNAS
6nontoxic goiter31.1BGLAP, TPO, TG, TSHR
7hypothyroidism31.0TPO, TG, TSHR, NKX2-1, SLC26A4
8toxic diffuse goiter31.0TPO, TG, TSHR
9hyperthyroidism30.8THRB, BGLAP, GNAS, TPO, TG, TSHR
10pendred syndrome30.8SLC26A4, TG, TPO
11thyrotoxicosis30.8TSHR, TG, TPO, THRB
12plummer's disease30.7TPO, TG
13autoimmune thyroiditis30.6TG, TPO
14papillary thyroid carcinoma30.6TPO, TG, TSHR, LGALS3
15thyroid cancer30.6SLC26A4, NKX2-1, CALCA, LGALS3, TSHR, TG
16hyperparathyroidism30.6CALCA, BGLAP
17primary hyperparathyroidism30.5BGLAP, CALCA
18adenoma30.5THRB, GNAS, TPO, TG, TSHR, LGALS3
19follicular thyroid carcinoma30.4THRB, TG, TSHR, CALCA
20parathyroid adenoma30.4GNAS, LGALS3, CALCA
21congenital hypothyroidism30.3GNAS, TPO, TG, TSHR, NKX2-1
22myxedema30.3TPO, TG, TSHR
23thyroid adenoma30.3LGALS3, TSHR, TG, TPO, GNAS
24papillary carcinoma30.1GNAS, SLC26A4, NKX2-1, CALCA, LGALS3, TSHR
25leydig cell tumor30.1GNAS
26acromegaly30.1GNAS, BGLAP
27mental retardation30.0THRB, GNAS, TSHR
28subacute thyroiditis29.9TG
29hyperthyroxinemia29.9TPO, TSHR
30addison's disease29.9TG, TPO
31paraganglioma29.8CALCA, TG
32teratoma29.8TG, NKX2-1
33struma ovarii29.8NKX2-1, TSHR, TG
34hypoparathyroidism29.8CALCA, BGLAP
35fibrous dysplasia29.8GNAS, BGLAP
36follicular adenoma29.7TSHR, TG, TPO, GNAS, LGALS3, CALCA
37substernal goiter10.8
38mediastinitis10.6
39lingual goiter10.3
40blindness10.3
41amyloidosis10.3
42cervicitis10.3
43laryngitis10.2
44superior vena cava syndrome10.2
45bird-headed dwarfism with progressive ataxia, insulin-resistant diabetes, goiter and primary gonadal insufficiency10.2
46daneman davy mancer syndrome10.2
47goiter, multinodular 1, with or without sertoli-leydig cell tumors10.2
48dyshormonogenic goiter10.1
49respiratory failure10.1
50cherubism10.1CALCA

Graphical network of the top 20 diseases related to Goiter:



Diseases related to goiter

Symptoms for Goiter

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Drugs & Therapeutics for Goiter

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Goiter

Drug clinical trials:

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Search NIH Clinical Center for Goiter

Search CenterWatch for Goiter

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Goiter

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Anatomical Context for Goiter

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34MalaCards
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MalaCards organs/tissues related to Goiter:

34
Thyroid, Bone, Testes, Pituitary, Trachea, Breast, Endothelial, T cells, Lymph node, Lung, Kidney, Colon, Heart, Cortex, Whole blood, Tonsil, Salivary gland

Animal Models for Goiter or affiliated genes

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38MGI
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Publications for Goiter

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53PubMed
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Articles related to Goiter:

(show top 50)    (show all 1391)
idTitleAuthorsYear
1
Mediastinal goiter presenting with ventricular tachycardia. (22302698)
2013
2
Hemithyroidectomy Versus Dunhill for Surgical Treatment of Asymmetrical Multinodular Goiter. (24253155)
2013
3
Huge multinodular goiter with mid trachea obstruction: indication for fiberoptic intubation. (23330421)
2012
4
Preoperative a8^a8^mTc-sestamibi scintigraphy in patients with primary hyperparathyroidism and concomitant nodular goiter: comparison of SPECT-CT, SPECT, and planar imaging. (22825041)
2012
5
Monosomy and ring chromosome 13 in a thyroid nodular goiter-do we underestimate its relevance in benign thyroid lesions? (22469512)
2012
6
Multinodular goiter as the initial presentation of systemic sarcoidosis: limitation of fine-needle biopsy. (21352663)
2011
7
Localized advanced hA1rthle cell carcinoma with symptomatic intrathoracic goiter. (22606586)
2011
8
Genetics and phenomics of hypothyroidism and goiter due to NIS mutations. (20153805)
2010
9
Thyroid cancers amongst goiter population in a Nigerian tertiary hospital: surgical and radiographic perspective. (21526634)
2010
10
Perinatal goiter with increased iodine uptake and hypothyroidism due to excess maternal iodine ingestion. (19844123)
2009
11
Optimizing 131I uptake after rhTSH stimulation in patients with nontoxic multinodular goiter: evidence from a prospective, randomized, double-blind study. (19403877)
2009
12
Familial risks for hospitalized Graves' disease and goiter. (19661127)
2009
13
Serum hepatocyte growth factor is increased in Hashimoto's thyroiditis whether or not it is associated with nodular goiter as compared with healthy non-goitrous individuals. (19468262)
2009
14
Images in vascular medicine. A chronic compression of the upper mediastinal veins by a retrosternal goiter. (19651681)
2009
15
Does fine-needle aspiration cytology optimize the surgical management of thyroid disorders in endemic goiter region? (18202924)
2008
16
Radioiodine therapy for multinodular goiter. (22964127)
2008
17
Surgical excision of large multinodular goiter using an endoscopic transaxillary approach: a case report. (18936685)
2008
18
Normocalcemic, subclinical, asymptomatic primary hyperparathyroidism in patients with goiter or papillary thyroid cancer--preliminary report. Normocalcemic primary hyperparathyroidism and thyroid pathology. (17966885)
2007
19
C8orf4/TC-1 (thyroid cancer-1) gene expression in thyroid cancer and goiter. (17167272)
2007
20
Gender-specific determinants of goiter. (17194923)
2006
21
Complete inhibition of goiter in mice requires combined gene therapy modification of angiopoietin, vascular endothelial growth factor, and fibroblast growth factor signaling. (15817662)
2005
22
Iodine and zinc, but not selenium and copper, deficiency exists in a male Turkish population with endemic goiter. (10468158)
1999
23
Total thyroidectomy for multinodular goiter. (9851343)
1998
24
Endemic goiter and thyroid function in central-southern Sardinia. Report on an extensive epidemiological survey. (7868805)
1994
25
Hypothyroidism and goiter in a patient during treatment with interleukin-2. (2340468)
1990
26
Visualization of suppressed normal thyroid tissue by thallium-201 in patients with toxic nodular goiter. (3370895)
1988
27
Toxic multinodular goiter: a variant of autoimmune hyperthyroidism. (2888784)
1987
28
Pemphigus foliaceus coexisting with toxic, multinodular goiter. (3771047)
1986
29
Pilot study to detect neurologic disease in Ecuador among a population with a high prevalence of endemic goiter. (3831782)
1985
30
Sequestered substernal goiter. (6625801)
1983
31
Thyroid hormone and immunological studies in endemic goiter. (6309889)
1983
32
Pituitary thyroid recovery following surgery in TRH-unresponsive patients with uni- and multinodular goiter. (409657)
1977
33
Studies on the effect of salt iodization on endemic goiter, Taiwan. I. Mass survey on goiter of school children. (1068220)
1976
34
Neonatal hypothyroidism and goiter in one infant of each of two sets of twins due to maternal therapy with antithyroid drugs. (4135477)
1974
35
Physical growth and development, neurological maturation and behavioral functioning in two Ecuadorian Andean communities in which goiter is endemic. I. Outline of the problem of endemic goiter and cretinism. Physical growth and neurological maturation in the adult population of La Esperanza. (4682523)
1973
36
Iodine metabolism in endemic goiter in Turkey. I. The kinetics of 131-I and organic iodine. (4125988)
1973
37
Iodine nutriture and prevalence of endemic goiter in USA. (4523766)
1973
38
Endemic goiter in Greece: nutritional status, growth, and skeletal development of goitrous and non goitrous populations. (4357119)
1973
39
I-131 treatment for toxic diffuse goiter. Analysis of 594 cases treated with repeated doses of 7 millicuries or less. (5281463)
1971
40
Electroencephalogram in juvenile endemic goiter and in acute goiter. (5113948)
1971
41
Nontoxic nodular goiter and carcinoma of the thyroid in children 15 years of age and younger. (6022975)
1967
42
Iodine deficiency in two endemic goiter areas of central and southern Italy. (4160409)
1966
43
A study on biosynthesis of iodoamino acids in the nodule and paranodular thyroid tissue in nontoxic nodular goiter with special reference to the application of paper chromatographic analysis using Na-I-131. (5913196)
1966
44
PROGNOSTIC VALUE OF 24-HOUR RADIOACTIVE IODINE UPTAKE; STUDIES IN PATIENTS WITH NODULAR GOITER AND DIFFUSE HYPERPLASTIC GOITER EIGHT TO TEN WEEKS FOLLOWING THERAPY WITH RADIOIODINE (I 131). (14160118)
1964
45
Prevention of endemic goiter in the Azerbaijan SSR]. (13675118)
1959
46
Endemic goiter. (13441193)
1957
47
Nodular goiter and carcinoma of the thyroid. (14368002)
1955
48
Endemic goiter in Latin America. (13134444)
1954
49
A Note on Chatin and the Hypothesis that Endemic Goiter is Due to a Lack of Iodine. (17810911)
1950
50
Iodine-lack theory and endemic goiter. (18901293)
1947

Variations for Goiter

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Expression for genes affiliated with Goiter

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Goiter

Search GEO for disease gene expression data for Goiter.

Pathways for genes affiliated with Goiter

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51PathCards, 39NCBI BioSystems Database, 13EMD Millipore, 31KEGG, 54QIAGEN, 56Reactome, 61Thomson Reuters
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Compounds for genes affiliated with Goiter

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Sources:
46Novoseek, 25HMDB, 3BitterDB, 12DrugBank, 52PharmGKB, 30IUPHAR, 62Tocris Bioscience
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Compounds related to Goiter according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1iodotyrosine46 2511.2TG, TPO
2diiodotyrosine4610.2TG, TPO
3111in-pentetreotide4610.0CALCA, TG
4propylthiouracil46 3 1211.9TSHR, TG, TPO
5amiodarone46 52 30 1212.9TG, TPO, THRB
6125i469.9TSHR, TG, TPO
7perchlorate469.8TPO, TG, SLC26A4
8octreotide46 62 30 1212.7GNAS, TG, CALCA
9ipriflavone469.6CALCA, BGLAP
10calcium gluconate469.5CALCA, BGLAP
11asparagine469.5GNAS, TPO, TSHR
12triiodothyroacetic acid469.5TG, BGLAP, THRB
13carbimazole46 1210.4BGLAP, TPO, TSHR
1424,25-dihydroxyvitamin d3469.3BGLAP, CALCA
15acth469.3GNAS, TPO, TSHR, LGALS3
16sialic acid469.3GNAS, TG, TSHR, LGALS3
17teriparatide46 1210.3BGLAP, CALCA
18triiodothyronine469.2THRB, TPO, TG, TSHR, SLC26A4
19etidronate469.2BGLAP, CALCA
20guanine46 25 1211.2THRB, GNAS, TG, TSHR, CALCA
21methimazole46 3 1211.2TSHR, TG, TPO, BGLAP
22iodine46 2510.1GNAS, TPO, TG, TSHR, SLC26A4
23adenylate469.1GNAS, TPO, TG, TSHR, CALCA
24hydrocortisone46 3 62 1212.1CALCA, TG, TPO, BGLAP
25polysaccharide469.0GNAS, TPO, TG, TSHR, LGALS3
26alfacalcidol46 62 1211.0BGLAP, CALCA
27sodium iodide468.9SLC26A4, NKX2-1, TSHR, TG, TPO
28glutamine468.9LGALS3, TSHR, TG, GNAS
29iodide46 259.9SLC26A4, NKX2-1, TSHR, TG, TPO
30sodium46 259.8TPO, TG, TSHR, NKX2-1, SLC26A4
31forskolin46 52 1210.8GNAS, TPO, TSHR, CALCA, NKX2-1
32testosterone46 62 25 1211.7THRB, BGLAP, TPO, TG, CALCA
33vitamin d468.7CALCA, LGALS3, BGLAP, THRB
34glutamate468.6GNAS, TPO, TG, TSHR, LGALS3, CALCA
35ribonucleic acid468.6THRB, GNAS, TPO, TG, TSHR, NKX2-1
36nitric oxide46 25 1210.6SLC26A4, CALCA, LGALS3, TPO, GNAS
37progesterone46 30 62 25 1212.6THRB, GNAS, TSHR, LGALS3, NKX2-1
38oligonucleotide468.6GNAS, TPO, TSHR, LGALS3, NKX2-1
39threonine468.4THRB, GNAS, TSHR, LGALS3, NKX2-1
40h2o2468.4BGLAP, TPO, TG, LGALS3, SLC26A4
41vegf468.4BGLAP, TG, TSHR, LGALS3, CALCA
42paraffin468.3BGLAP, TG, TSHR, LGALS3, NKX2-1
43alanine468.2THRB, BGLAP, GNAS, TG, TSHR, LGALS3
44thyroxine46 259.0THRB, BGLAP, TPO, TG, TSHR, CALCA
45arginine467.9THRB, BGLAP, GNAS, TPO, TG, TSHR
46cysteine467.9THRB, BGLAP, GNAS, TPO, TG, TSHR
47retinoic acid46 258.7THRB, BGLAP, TPO, TG, TSHR, LGALS3
48tyrosine467.6THRB, GNAS, TPO, TG, TSHR, LGALS3
49estrogen467.6THRB, BGLAP, TG, TSHR, LGALS3, CALCA
50serine467.5THRB, BGLAP, GNAS, TG, TSHR, LGALS3

GO Terms for genes affiliated with Goiter

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17Gene Ontology
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Cellular components related to Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendriteGO:0304258.7DICER1, GNAS, BGLAP
2extracellular spaceGO:0056157.9CALCA, LGALS3, TG, TPO, BGLAP

Biological processes related to Goiter according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:04244610.1TG, TPO
2thyroid hormone generationGO:00659010.1TG, TPO
3monocyte chemotaxisGO:0025489.7LGALS3, CALCA
4activation of adenylate cyclase activityGO:0071909.7GNAS, CALCA
5adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.7CALCA, GNAS
6thyroid gland developmentGO:0308789.7NKX2-1, TG
7embryonic hindlimb morphogenesisGO:0351169.6GNAS, DICER1
8positive regulation of cAMP biosynthetic processGO:0308199.4CALCA, GNAS
9bone developmentGO:0603489.1GNAS, BGLAP

Products for genes affiliated with Goiter

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Sources for Goiter

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet