MCID: GTR002
MIFTS: 52

Goiter malady

Categories: Endocrine diseases

Aliases & Classifications for Goiter

Aliases & Descriptions for Goiter:

Name: Goiter 12 29 52 42 14 69
Goitre 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:12176
ICD10 33 E04.9
ICD9CM 35 240.9
MeSH 42 D006042
NCIt 47 C26785
UMLS 69 C0018021

Summaries for Goiter

Disease Ontology : 12 A thyroid gland disease that involves an abnormal enlargement of the thyroid gland.

MalaCards based summary : Goiter, also known as goitre, is related to endemic goiter and thyroid hormone resistance, autosomal recessive. An important gene associated with Goiter is TG (Thyroglobulin), and among its related pathways/superpathways are Insulin secretion and G alpha (s) signalling events. The drugs Remifentanil and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and testes, and related phenotypes are Increased HPV16-GFP infection and endocrine/exocrine gland

Wikipedia : 71 A goitre, also spelled goiter, is a swelling of the neck or larynx resulting from enlargement of the... more...

Related Diseases for Goiter

Diseases related to Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 238)
id Related Disease Score Top Affiliating Genes
1 endemic goiter 33.0 BGLAP CALCA SERPINA7 TG TPO TSHR
2 thyroid hormone resistance, autosomal recessive 31.0 SERPINA7 THRB TRH TXNRD2
3 nodular goiter 12.2
4 multinodular goiter 12.2
5 goiter, multinodular 1, with or without sertoli-leydig cell tumors 12.2
6 substernal goiter 12.0
7 nontoxic goiter 12.0
8 pendred syndrome 12.0
9 toxic diffuse goiter 12.0
10 lingual goiter 11.9
11 dyshormonogenic goiter 11.8
12 graves' disease 11.8
13 goiter, multinodular, cystic renal disease, and digital anomalies 11.7
14 deafness goiter stippled epiphyses 11.7
15 plummer's disease 11.4
16 familial thyroid dyshormonogenesis 11.3
17 hypothyroidism 11.1
18 hyperthyroidism 11.1
19 hashimoto thyroiditis 11.0
20 pendred syndrome/dfnb4 10.8
21 bangstad syndrome 10.8
22 daneman davy mancer syndrome 10.8
23 thyroid dyshormonogenesis 3 10.8
24 dicer1-related pleuropulmonary blastoma cancer predisposition syndrome 10.8
25 short stature, microcephaly, and endocrine dysfunction 10.8
26 thyroiditis 10.7
27 cln4 disease 10.7
28 thyroid cancer, nonmedullary, 4 10.7
29 hyperthyroidism, nonautoimmune 10.7
30 thyroid dyshormonogenesis 5 10.7
31 thyroid cancer, anaplastic 10.7
32 blepharochalasis and double lip 10.7
33 retinal dystrophy with or without extraocular anomalies 10.7
34 thyroid hormone resistance 10.7
35 thyroid angiosarcoma 10.7
36 thyroid dyshormonogenesis 4 10.7
37 myopathy - thyrotoxic 10.7
38 fibrous meningioma 10.3 TG TPO
39 endophthalmitis 10.3 CALCA TG
40 hyperthyroidism, familial gestational 10.3 GNAS TSHR
41 acute hemorrhagic encephalitis 10.3 TG TSHR
42 thyroid cancer 10.3
43 conjunctival deposit 10.2 TG TPO TSHR
44 tick paralysis 10.2 TG THRB TPO
45 denys-drash syndrome 10.2 TG TPO TSHR
46 corneal ectasia 10.2 CALCA TG
47 atheroembolism of kidney 10.2 TG TRH
48 superior vena cava angiosarcoma 10.2 CALCA TG
49 mediastinitis 10.2
50 perineural angioma 10.2 CALCA TG

Comorbidity relations with Goiter via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Hypothyroidism
Nodular Goiter

Graphical network of the top 20 diseases related to Goiter:



Diseases related to Goiter

Symptoms & Phenotypes for Goiter

GenomeRNAi Phenotypes related to Goiter according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased HPV16-GFP infection GR00350-A 8.92 GNAS PAX8 SERPINA7 TRH

MGI Mouse Phenotypes related to Goiter:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.14 TPO TRH TSHR DICER1 DUOX2 GNAS
2 homeostasis/metabolism MP:0005376 10.1 DICER1 DUOX2 GNAS NKX2-1 PAX8 SLC26A4
3 hearing/vestibular/ear MP:0005377 9.91 DUOX2 GNAS PAX8 SLC26A4 THRB TPO
4 nervous system MP:0003631 9.9 DICER1 DUOX2 GNAS NKX2-1 PAX8 SLC26A4
5 limbs/digits/tail MP:0005371 9.73 DICER1 GNAS PAX8 THRB TPO TSHR
6 no phenotypic analysis MP:0003012 9.5 DICER1 GNAS NKX2-1 PAX8 THRB TRH
7 skeleton MP:0005390 9.28 TPO TSHR DICER1 DUOX2 GNAS NKX2-1

Drugs & Therapeutics for Goiter

Drugs for Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 215)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Remifentanil Approved Phase 4 132875-61-7 60815
2
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
4
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
5
Propylthiouracil Approved Phase 4,Phase 3,Phase 2 51-52-5 657298
6
Bimatoprost Approved, Investigational Phase 4,Phase 3 155206-00-1 5311027
7
Latanoprost Approved, Investigational Phase 4 130209-82-4 5282380 5311221
8
Timolol Approved Phase 4 26839-75-8 33624 5478
9
Travoprost Approved Phase 4 157283-68-6 5282226
10
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
11
Acetylcholine Approved Phase 4,Phase 2,Phase 3 51-84-3 187
12
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
13
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
14
Propranolol Approved, Investigational Phase 4 525-66-6 4946
15
Dinoprost Tromethamine Approved, Vet_approved Phase 4 38562-01-5 5282415
16
Ephedrine Approved Phase 4 299-42-3 9294
17
Pseudoephedrine Approved Phase 4 90-82-4 7028
18
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 1 50-02-2 5743
19
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
20
rituximab Approved Phase 4,Phase 2,Phase 3,Phase 1 174722-31-7 10201696
21
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
22
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
23
leucovorin Approved, Nutraceutical Phase 4 58-05-9 54575, 6560146 143
24
Maleic acid Experimental Phase 4 110-16-7 444266
25 Autoantibodies Phase 4
26 Analgesics Phase 4,Phase 3,Phase 2
27 Analgesics, Opioid Phase 4
28 Anesthetics Phase 4,Phase 3,Phase 2
29 Anesthetics, General Phase 4
30 Anesthetics, Intravenous Phase 4
31 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
32 Hypnotics and Sedatives Phase 4
33 Narcotics Phase 4
34 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
35 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1
36 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
37 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1
38 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
39 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
40 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1
41 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
42 Hormones Phase 4,Phase 3,Phase 2,Phase 1
43 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
44 Methylprednisolone acetate Phase 4,Phase 2,Phase 3
45 Methylprednisolone Hemisuccinate Phase 4,Phase 2,Phase 3
46 Neuroprotective Agents Phase 4,Phase 2,Phase 3
47 Prednisolone acetate Phase 4,Phase 2,Phase 3
48 Prednisolone hemisuccinate Phase 4,Phase 2,Phase 3
49 Prednisolone phosphate Phase 4,Phase 2,Phase 3
50 Protective Agents Phase 4,Phase 2,Phase 3

Interventional clinical trials:

(show top 50) (show all 167)
id Name Status NCT ID Phase
1 The Role of Levothyroxine on Goiter With Atypia of Undetermined Significance Unknown status NCT02329379 Phase 4
2 Effect of Higher Doses of Remifentanil on Postoperative Pain in Patients Undergoing Thyroidectomy Unknown status NCT01761149 Phase 4
3 Total Thyroidectomy With Harmonic Scalpel® Unknown status NCT00385983 Phase 4
4 A Prospective, Randomized Trial of Intravenous Pulse Versus Sequential Steroid Therapy for Patients With Graves' Orbitopathy Unknown status NCT01969019 Phase 4
5 The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy Unknown status NCT01056419 Phase 4
6 The Secondary Beneficial Effects of Prostaglandin Analog Treatment in Thyroid Eye Disease Patients. Unknown status NCT01927406 Phase 4
7 LISA-study : Levothyroxin in Nodular Goiter Completed NCT00277589 Phase 4
8 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4
9 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4
10 Is the Routine Pressure Dressing After Thyroidectomy Necessary? Completed NCT00400465 Phase 4
11 Adjuvant Treatment of Graves´ Ophthalmopathy With NSAID (aGO Study) Completed NCT01458600 Phase 4
12 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4
13 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4
14 Impact of SSKI Pre-Treatment on Blood Loss in Thyroidectomy for Graves Disease Completed NCT00946296 Phase 4
15 Prevention Relapse of Graves' Disease by Intrathyroid Injection of Dexamethasone Completed NCT00917241 Phase 4
16 Using A Novel Classification System in Intravenous GCs Therapy of TAO: A Multi-central, Randomized, Open, Superior Trial Recruiting NCT03107078 Phase 4
17 Rituximab (RTX) Therapy in Patients With Active TAO Recruiting NCT02378298 Phase 4
18 Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Recruiting NCT01738243 Phase 4
19 A Trial to Evaluate the Efficacy of Orbital Radiotherapy in Graves' Orbitopathy Not yet recruiting NCT03098225 Phase 4
20 Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease Not yet recruiting NCT02339142 Phase 4
21 Effects of Statins in Graves' Orbitopathy (GO) in Hypercholesterolemic Patients Not yet recruiting NCT03110848 Phase 4
22 Use of Botox in the Management of Thyroid Related Upper Eyelid Retraction Withdrawn NCT01272414 Phase 4
23 Efficacy of Ropivacaine (With Epinephrine) in BABA Endoscopic and Robotic Thyroidectomy Unknown status NCT02112370 Phase 3
24 Laser Therapy of Benign Thyroid Nodules Unknown status NCT00150150 Phase 3
25 Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye Disease Unknown status NCT00370734 Phase 2, Phase 3
26 Treatment of Soft Tissue Expansion in Inactive Thyroid Eye Disease Patients Using Drops of Prostaglandin Analogues Unknown status NCT02155049 Phase 3
27 Prednisone Versus Doxycycline in the Treatment of Graves' Orbitopathy Unknown status NCT01809444 Phase 2, Phase 3
28 Clinical Trial on Harmonic Focus Shears Completed NCT01003652 Phase 2, Phase 3
29 Comparison of Different Doses of 131I in Severe Graves' Hyperthyroidism Completed NCT01039818 Phase 3
30 Assessing the Impact of the Early and Systematic Hormonal Replacement After Radio-isotopic Ablation of Graves'hyperthyroïdism on Quality of Life, Efficiency and Tolerance Completed NCT01295333 Phase 3
31 Trial of Rituximab for Graves' Ophthalmopathy Completed NCT00595335 Phase 2, Phase 3
32 Tocilizumab Treatment in Graves´ Ophthalmopathy (Graves´ Orbitopathy or Thyroid Eye Disease) Completed NCT01297699 Phase 3
33 Total Thyroidectomy Versus Thionamides in Patients With Moderate-to-Severe Graves' Ophthalmopathy Recruiting NCT03066076 Phase 3
34 Bupivacaine Injection of Eye Muscles to Treat Strabismus Recruiting NCT01616108 Phase 2, Phase 3
35 The Effect of Intravenous Glucocorticoids on the Tearfilm in Eyes With Thyroid-associated Ophthalmopathy Recruiting NCT01579539 Phase 3
36 Early Levothyroxine Post Radioactive Iodine Active, not recruiting NCT01950260 Phase 2, Phase 3
37 Treatment of Graves´Ophthalmopathy With Diclofenac or Simvastatin (GO-DS) Not yet recruiting NCT03131726 Phase 3
38 The Effect of a New Antioxidant Combination (ASTED) on Moderate to Severe Thyroid Eye Disease Not yet recruiting NCT02422368 Phase 2, Phase 3
39 The Effect of a New Antioxidant Combination (ASTED) on Mild Thyroid Eye Disease (TED) Not yet recruiting NCT02393183 Phase 2, Phase 3
40 Doxycycline Treatment in Mild Graves' Orbitopathy Unknown status NCT02203682 Phase 2
41 Role of the Microbiome in Graves' Orbitopathy Unknown status NCT02373995 Phase 1, Phase 2
42 Study to Determine the Dose, the Safety and Effectiveness of a New Drug, Modified Release rhTSH, in Patients With Multinodular Goiter Completed NCT00454220 Phase 2
43 rhTSH, Radioiodine Uptake and Goiter Reduction Following 131I Therapy in Patients With Benign Nontoxic Nodular Goiter Completed NCT00275171 Phase 2
44 rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter Completed NCT00145366 Phase 2
45 Health-Related Quality of Life for Thyroid Patients Completed NCT00150033 Phase 2
46 Efficacy of Subantimicrobial Dose Doxycycline for Moderate to Severe and Active Graves' Orbitopathy Completed NCT01727973 Phase 1, Phase 2
47 Effects Of Oral Alfacalcidol On Maturation Of Dendritic Cells In Graves' Disease Patients Completed NCT02993302 Phase 2
48 A Study to Evaluate the Safety and Effect of CFZ533 on Patients With Graves' Disease Completed NCT02713256 Phase 2
49 Radioactive Iodide Therapy for Pediatric Graves' Disease Completed NCT01269749 Phase 2
50 Rituximab in the Treatment of Graves' Disease Completed NCT00150111 Phase 1, Phase 2

Search NIH Clinical Center for Goiter

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: goiter

Genetic Tests for Goiter

Genetic tests related to Goiter:

id Genetic test Affiliating Genes
1 Goiter 29

Anatomical Context for Goiter

MalaCards organs/tissues related to Goiter:

39
Thyroid, Bone, Testes, Breast, Pituitary, Trachea, Lung

Publications for Goiter

Articles related to Goiter:

(show top 50) (show all 1583)
id Title Authors Year
1
Prenatal diagnosis and successful intrauterine treatment of severe congenital hypothyroidism associated with fetal goiter. ( 27862717 )
2017
2
Poor dietary diversity, wealth status and use of un-iodized salt are associated with goiter among school children: a cross-sectional study in Ethiopia. ( 28061776 )
2017
3
Myasthenia Gravis, Mediastinal Goiter, and Crohn's Disease. ( 28528037 )
2017
4
Associations between iodine intake, thyroid volume, and goiter rate in school-aged Chinese children from areas with high iodine drinking water concentrations. ( 27927635 )
2017
5
Phonatory symptoms and impact on quality of life in female patients with goiter. ( 27434485 )
2016
6
Recombinant human thyrotropin stimulated 131I treatment for multinodular goiter. ( 27480576 )
2016
7
Incidental Papillary Thyroid Microcarcinoma in an Endemic Goiter Area. ( 26949559 )
2016
8
Diffuse toxic goiter and coexisting hurthle cell carcinoma of thyroid presenting as lower limb weakness from mononeuritis multiplex. ( 27728172 )
2016
9
Fetal hypothyroidism induced by maternal anti-TSH receptor blocking antibodies and complicated by polyhydramnios despite the absence of goiter. Treatment by intra-amniotic injections of levothyroxine. ( 27919402 )
2016
10
Total Thyroidectomy versus Bilateral Subtotal Thyroidectomy for Bilateral Multinodular Nontoxic Goiter: A Meta-Analysis. ( 27256349 )
2016
11
Intermittent neural monitoring of the recurrent laryngeal nerve in surgery for recurrent goiter. ( 27867862 )
2016
12
Risk of Malignancy in Symptomatic Nodular Goiter Treated with Radiofrequency Ablation. ( 26585266 )
2016
13
Patient outcomes following surgical management of multinodular goiter: Does multinodularity increase the risk of thyroid malignancy? ( 27428220 )
2016
14
Long-Standing Goiter Causing Acute Airway Compromise. ( 27173499 )
2016
15
A likely case of goiter in the Madonna col Bambino dormiente (1465/1470) by Andrea Mantegna (1431-1506). ( 27624299 )
2016
16
Fine needle aspiration cytology of 650 thyroid nodules operated for multinodular goiter: a cyto-histological correlation based on the new Italian cytological classification (siapec 2014). ( 28078873 )
2016
17
Missed retrosternal ectopic thyroid tissue in a patient operated for multinodular goiter. ( 26985161 )
2016
18
Strategies of laparoscopic thyroidectomy for treatment of substernal goiter via areola approach. ( 27005286 )
2016
19
Bilateral benign multinodular goiter: What is the adequate surgical therapy? A review of literature. ( 26708850 )
2016
20
A Rare Case of a Postoperative Submandibular Exophytic Goiter in a Patient With a Recurrent Normotopic Nodular Goiter. ( 27055140 )
2016
21
Hair Trace Elements are Associated with Increased Thyroid Volume in Schoolchildren with Goiter. ( 27106540 )
2016
22
A Novel Germline Mutation of KEAP1 (R483H) Associated with a Non-Toxic Multinodular Goiter. ( 27703446 )
2016
23
Delayed Presentation of Forgotten Thyroid Goiter - 25 Years After Thyroidectomy. ( 27806818 )
2016
24
Rare Intensely Fluorine-18-fluorodeoxyglucose Avid Large Retropharyngeal Goiter in a Patient with Invasive Breast Carcinoma. ( 27195179 )
2016
25
Takotsubo Cardiomyopathy Associated with Primary Hyperthyroidism Secondary to Toxic Multinodular Goiter. ( 28031674 )
2016
26
New Daily Persistent Headache Caused by a Multinodular Goiter and Headaches Associated With Thyroid Disease. ( 28025831 )
2016
27
Upregulation of TSHR, TTF-1, and PAX8 in Nodular Goiter Is Associated with Iodine Deficiency in the Follicular Lumen. ( 27525008 )
2016
28
Is the TSHR D727E polymorphism a genetic predisposition for multinodular goiter in the Turkish population? ( 27525921 )
2016
29
A GOITER IN CHRIST IN CRUCIFIXION. ( 27539119 )
2016
30
Forgotten goiter: Diagnosis and management. A case report and literature review. ( 27639205 )
2016
31
Fetal goiter associated with preconception hysterosalpingography using an oil-soluble iodinated contrast medium. ( 26935488 )
2016
32
Lack of Variation in Inflammatory Hematological Parameters between Benign Nodular Goiter and Papillary Thyroid Cancer. ( 27221938 )
2016
33
SHOULD FNA BE PERFORMED IN PATIENTS WITH A MULTI-NODULAR GOITER AND COMPRESSIVE SYMPTOMS? ( 27042747 )
2016
34
Erratum to: Strategies of laparoscopic thyroidectomy for treatment of substernal goiter via areola approach. ( 27387178 )
2016
35
Preoperative risk factors in total thyroidectomy of substernal goiter. ( 27932888 )
2016
36
Differentiation of thyroid nodules in multinodular goiter with the application of technical ultrasound advances - initial results. ( 26884295 )
2016
37
Case report of the use of videolaryngoscopy in thyroid goiter masses: An airway challenge. ( 27598013 )
2016
38
Lemierre's syndrome presenting as acute thyroid goiter. ( 27381469 )
2016
39
Expression patterns of cytokeratin 5/6 and p63 in thyroid sporadic nodular goiter. ( 26878564 )
2016
40
Goiter In The Art Of Renaissance Europe. ( 27154774 )
2016
41
Multinodular goiter with adipose metaplasia: A case report. ( 27772959 )
2016
42
Extrathyroidal Calcitonin Secreting Tumors: Pancreatic Neuroendocrine Tumors in Patients With Multinodular Goiter: Two Case Reports. ( 26817871 )
2016
43
Vitamin D status in Egyptian euthyroid multinodular non-toxic goiter patients and its correlation with TSH levels. ( 27552913 )
2016
44
Genetic and functional analysis of two missense DUOX2 mutations in congenital hypothyroidism and goiter. ( 27421132 )
2016
45
Quality-of-Life Impairments Persist Six Months After Treatment of Graves' Hyperthyroidism and Toxic Nodular Goiter: A Prospective Cohort Study. ( 27370744 )
2016
46
DurA!n Madonna (c. 1435-1438) by Rogier van der Weyden: a case of congenital goiter. ( 27460951 )
2016
47
Intrathyroid salivary adenocartinoma not otherwise specified and parathyroid adenoma in multinodular goiter. ( 27055746 )
2016
48
Deep sequencing reveals spatially distributed distinct hotspot mutations in DICER1-related multinodular goiter. ( 27459524 )
2016
49
Iodinated Contrast Media-Induced Thyroid Dysfunction in Euthyroid Nodular Goiter Patients. ( 27315873 )
2016
50
Embolization of thyroid arteries in a patient with compressive intrathoracic goiter ineligible to surgery or radioiodine therapy. ( 27623028 )
2016

Variations for Goiter

Expression for Goiter

Search GEO for disease gene expression data for Goiter.

Pathways for Goiter

GO Terms for Goiter

Biological processes related to Goiter according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.67 DUOX2 IYD TPO TXNRD2
2 positive regulation of cAMP biosynthetic process GO:0030819 9.65 CALCA GNAS TSHR
3 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.63 CALCA GNAS TSHR
4 activation of adenylate cyclase activity GO:0007190 9.61 CALCA GNAS TSHR
5 hydrogen peroxide catabolic process GO:0042744 9.52 DUOX2 TPO
6 positive regulation of adenylate cyclase activity GO:0045762 9.51 CALCA TSHR
7 hormone biosynthetic process GO:0042446 9.5 DUOX2 TG TPO
8 cellular response to gonadotropin stimulus GO:0071371 9.49 PAX8 SLC5A5
9 thyroid hormone metabolic process GO:0042403 9.43 DUOX2 IYD TG
10 thyroid-stimulating hormone signaling pathway GO:0038194 9.4 PAX8 TSHR
11 iodide transport GO:0015705 9.33 SLC26A4 SLC5A5 TG
12 thyroid gland development GO:0030878 9.26 DUOX2 NKX2-1 PAX8 TG
13 thyroid hormone generation GO:0006590 8.92 DUOX2 IYD SLC5A5 TPO

Molecular functions related to Goiter according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.43 CALCA TG TRH
2 iodide transmembrane transporter activity GO:0015111 9.16 SLC26A4 SLC5A5
3 iodide peroxidase activity GO:0004447 8.96 IYD TPO
4 thyroid-stimulating hormone receptor activity GO:0004996 8.62 PAX8 TSHR

Sources for Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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