Aliases & Classifications for Goiter

MalaCards integrated aliases for Goiter:

Name: Goiter 12 28 51 41 14 69
Goitre 12 72

Classifications:



External Ids:

Disease Ontology 12 DOID:12176
ICD10 32 E04.9
ICD9CM 34 240.9
MeSH 41 D006042
NCIt 46 C26785
UMLS 69 C0018021

Summaries for Goiter

Disease Ontology : 12 A thyroid gland disease that involves an abnormal enlargement of the thyroid gland.

MalaCards based summary : Goiter, also known as goitre, is related to goiter, multinodular 1, with or without sertoli-leydig cell tumors and nodular goiter. An important gene associated with Goiter is TG (Thyroglobulin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and G alpha (s) signalling events. The drugs Remifentanil and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include thyroid, eye and bone, and related phenotypes are Increased HPV16-GFP infection and endocrine/exocrine gland

Wikipedia : 72 A goitre or goiter is a swelling in the neck resulting from an enlarged thyroid gland. The term is also... more...

Related Diseases for Goiter

Diseases related to Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 277)
# Related Disease Score Top Affiliating Genes
1 goiter, multinodular 1, with or without sertoli-leydig cell tumors 34.3 DICER1 TG TPO
2 nodular goiter 33.7 CALCA TG TPO TSHR
3 plummer's disease 32.9 TG THRB TPO
4 endemic goiter 32.8 CALCA SERPINA7 TG TPO TSHR
5 pendred syndrome 32.5 DUOX2 PAX8 SLC26A4 TG TPO
6 nontoxic goiter 32.4 BGLAP CALCA SERPINA7 TG TPO TSHR
7 dyshormonogenic goiter 32.3 DUOX2 DUOXA2 SERPINA7 SLC26A4 TG
8 toxic diffuse goiter 32.3 CALCA SERPINA7 TG TPO TRH TSHR
9 graves' disease 32.2 GNAS SERPINA7 TG THRB TPO TSHR
10 hashimoto thyroiditis 31.8 CALCA SLC26A4 TG TPO TSHR
11 familial thyroid dyshormonogenesis 31.5 DUOX2 DUOXA2 IYD SLC5A5 TG TPO
12 multinodular goiter 31.4 CALCA DICER1 GNAS NKX2-1 PAX8 SLC26A4
13 thyroid cancer, anaplastic 31.3 NKX2-1 PAX8 TG
14 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.9 TG TPO TSHR
15 hyperthyroidism 30.5 BGLAP GNAS SERPINA7 TG THRB TPO
16 thyroid hormone resistance, generalized, autosomal dominant 30.4 SERPINA7 TG THRB TRH TXNRD2
17 myxedema 30.4 TG TPO TSHR
18 suppurative thyroiditis 30.1 CALCA TG
19 acute thyroiditis 30.0 CALCA TG
20 thyroid carcinoma, familial medullary 29.9 CALCA NKX2-1 TG
21 ovarian germ cell teratoma 29.7 NKX2-1 TG
22 hypothyroidism, congenital, nongoitrous, 2 29.6 NKX2-1 PAX8 SERPINA7 SLC26A4 TG TSHR
23 subacute thyroiditis 29.6 SERPINA7 TG TPO TSHR
24 thyroiditis 29.6 CALCA SERPINA7 TG THRB TPO TRH
25 struma ovarii 29.6 NKX2-1 TG TSHR
26 papillary thyroid microcarcinoma 29.5 CALCA NKX2-1 TG TSHR
27 fibrous dysplasia 29.4 BGLAP CALCA GNAS
28 hyperthyroxinemia 29.1 SERPINA7 TPO TRH TSHR
29 graves disease 1 29.0 SERPINA7 TG THRB TPO TRH TSHR
30 papillary carcinoma 28.6 CALCA NKX2-1 PAX8 TG TPO TSHR
31 neonatal hypothyroidism 28.5 PAX8 SLC5A5 TG TPO TSHR
32 thyroid cancer, nonmedullary, 1 28.4 CALCA NKX2-1 PAX8 SLC5A5 TG TPO
33 thyroid cancer, nonmedullary, 2 28.4 CALCA NKX2-1 PAX8 TG THRB TPO
34 follicular adenoma 28.4 CALCA NKX2-1 PAX8 TG TPO TSHR
35 differentiated thyroid carcinoma 28.2 BGLAP DICER1 NKX2-1 PAX8 TG TPO
36 hypothyroidism 28.2 DUOX2 DUOXA2 IYD NKX2-1 PAX8 SERPINA7
37 congenital hypothyroidism 27.9 DUOX2 IYD NKX2-1 PAX8 SLC5A5 TG
38 thyroid cancer 27.3 CALCA GNAS NKX2-1 PAX8 SLC26A4 SLC5A5
39 goiter, multinodular 2 12.1
40 goiter, multinodular 3 12.1
41 substernal goiter 12.1
42 lingual goiter 12.1
43 goiter, multinodular, cystic renal disease, and digital anomalies 11.9
44 deafness goiter stippled epiphyses 11.8
45 daneman davy mancer syndrome 11.8
46 dicer1-related pleuropulmonary blastoma cancer predisposition syndrome 11.2
47 bangstad syndrome 11.1
48 blepharochalasis and double lip 10.9
49 thyroid dyshormonogenesis 3 10.9
50 short stature, microcephaly, and endocrine dysfunction 10.9

Comorbidity relations with Goiter via Phenotypic Disease Network (PDN):


Acute Cystitis Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Hypothyroidism
Nodular Goiter

Graphical network of the top 20 diseases related to Goiter:



Diseases related to Goiter

Symptoms & Phenotypes for Goiter

GenomeRNAi Phenotypes related to Goiter according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased HPV16-GFP infection GR00350-A 8.92 GNAS PAX8 SERPINA7 TRH

MGI Mouse Phenotypes related to Goiter:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.14 TRH TSHR PAX8 DICER1 DUOX2 SLC26A4
2 homeostasis/metabolism MP:0005376 10.1 TPO TRH TSHR TXNRD2 DICER1 PAX8
3 craniofacial MP:0005382 9.91 TPO DICER1 PAX8 DUOXA2 GNAS THRB
4 hearing/vestibular/ear MP:0005377 9.91 TSHR PAX8 DUOX2 SLC26A4 GNAS THRB
5 nervous system MP:0003631 9.9 TRH TSHR TXNRD2 DICER1 PAX8 DUOX2
6 limbs/digits/tail MP:0005371 9.8 TSHR DICER1 PAX8 DUOXA2 GNAS THRB
7 no phenotypic analysis MP:0003012 9.5 TRH TXNRD2 NKX2-1 DICER1 PAX8 GNAS
8 skeleton MP:0005390 9.32 TSHR PAX8 DICER1 DUOX2 SLC26A4 DUOXA2

Drugs & Therapeutics for Goiter

Drugs for Goiter (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 219)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Remifentanil Approved Phase 4 132875-61-7 60815
2
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
4
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3 53-03-2 5865
5
Propylthiouracil Approved, Investigational Phase 4,Phase 3,Phase 2 51-52-5 657298
6
Iodine Approved, Investigational Phase 4,Phase 2,Phase 3 7553-56-2 807
7
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
8
Acetylcholine Approved Phase 4,Phase 2,Phase 3 51-84-3 187
9
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
10
Metoprolol Approved, Investigational Phase 4 51384-51-1, 37350-58-6 4171
11
Propranolol Approved, Investigational Phase 4,Phase 3 525-66-6 4946
12
Bimatoprost Approved, Investigational Phase 4,Phase 3 155206-00-1 5311027
13
Dinoprost Tromethamine Approved, Vet_approved Phase 4 38562-01-5 5282415
14
Ephedrine Approved Phase 4 299-42-3 9294
15
Pseudoephedrine Approved Phase 4 90-82-4 7028
16
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 1 50-02-2 5743
17
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
18
rituximab Approved Phase 4,Phase 2,Phase 3,Phase 1 174722-31-7 10201696
19
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
20
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
21
leucovorin Approved, Nutraceutical Phase 4 58-05-9 143 6006
22
Dinoprost Investigational Phase 4 551-11-1 5283078
23 Autoantibodies Phase 4
24 Analgesics Phase 4,Phase 3,Phase 2
25 Analgesics, Opioid Phase 4
26 Anesthetics Phase 4,Phase 3,Phase 2
27 Anesthetics, General Phase 4
28 Anesthetics, Intravenous Phase 4
29 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
30 Hypnotics and Sedatives Phase 4
31 Narcotics Phase 4
32 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
33 Antiemetics Phase 4,Phase 2,Phase 3,Phase 1
34 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
35 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3,Phase 1
36 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
37 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1
38 glucocorticoids Phase 4,Phase 2,Phase 3,Phase 1
39 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
40 Hormones Phase 4,Phase 2,Phase 3,Phase 1
41 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1
42 Methylprednisolone acetate Phase 4,Phase 2,Phase 3
43 Methylprednisolone Hemisuccinate Phase 4,Phase 2,Phase 3
44 Neuroprotective Agents Phase 4,Phase 2,Phase 3
45 Prednisolone acetate Phase 4,Phase 2,Phase 3
46 Prednisolone hemisuccinate Phase 4,Phase 2,Phase 3
47 Prednisolone phosphate Phase 4,Phase 2,Phase 3
48 Protective Agents Phase 4,Phase 2,Phase 3
49 Antimetabolites Phase 4,Phase 3
50 Antithyroid Agents Phase 4,Phase 3,Phase 1,Phase 2

Interventional clinical trials:

(show top 50) (show all 177)

# Name Status NCT ID Phase Drugs
1 The Role of Levothyroxine on Goiter With Atypia of Undetermined Significance Unknown status NCT02329379 Phase 4 Levothyroxine
2 Effect of Higher Doses of Remifentanil on Postoperative Pain in Patients Undergoing Thyroidectomy Unknown status NCT01761149 Phase 4 Remifentanil
3 Total Thyroidectomy With Harmonic Scalpel® Unknown status NCT00385983 Phase 4
4 A Prospective, Randomized Trial of Intravenous Pulse Versus Sequential Steroid Therapy for Patients With Graves' Orbitopathy Unknown status NCT01969019 Phase 4 methylprednisolone, prednisone
5 The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy Unknown status NCT01056419 Phase 4 Propylthiouracil
6 LISA-study : Levothyroxin in Nodular Goiter Completed NCT00277589 Phase 4 Levothyroxin-Na;Levothyroxine-Na + iodide;Iodide;Placebo
7 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4 Methimazole
8 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole
9 Is the Routine Pressure Dressing After Thyroidectomy Necessary? Completed NCT00400465 Phase 4
10 Adjuvant Treatment of Graves´ Ophthalmopathy With NSAID (aGO Study) Completed NCT01458600 Phase 4 Diclofenac;Methimazole;L-thyroxin;Propranolol;Metoprolol
11 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4 Bimatoprost;Eye drop solution
12 Impact of SSKI Pre-Treatment on Blood Loss in Thyroidectomy for Graves Disease Completed NCT00946296 Phase 4 Potassium Iodide
13 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
14 Prevention Relapse of Graves' Disease by Intrathyroid Injection of Dexamethasone Completed NCT00917241 Phase 4 MMI combined with IID;MMI
15 Using A Novel Classification System in Intravenous GCs Therapy of TAO: A Multi-central, Randomized, Open, Superior Trial Recruiting NCT03107078 Phase 4 Glucocorticoids
16 Rituximab (RTX) Therapy in Patients With Active TAO Recruiting NCT02378298 Phase 4 Rituximab;Iv Methylprednisolone;peroral methylprednisolone and Methotrexate
17 Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Recruiting NCT01738243 Phase 4 Hyaluronic Acid Gel injection;Saline injection
18 A Trial to Evaluate the Efficacy of Orbital Radiotherapy in Graves' Orbitopathy Not yet recruiting NCT03098225 Phase 4 Methylprednisolone
19 Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease Not yet recruiting NCT02339142 Phase 4 intravenous corticosteroids (methylprednisolone)
20 Effects of Statins in Graves' Orbitopathy (GO) in Hypercholesterolemic Patients Not yet recruiting NCT03110848 Phase 4 Atorvastatin;Methylprednisolone
21 The Secondary Beneficial Effects of Prostaglandin Analog Treatment in Thyroid Eye Disease Patients. Withdrawn NCT01927406 Phase 4 Prostaglandin Analog;Timolol
22 Use of Botox in the Management of Thyroid Related Upper Eyelid Retraction Withdrawn NCT01272414 Phase 4 Botulinum Toxin Type A;Saline injection
23 Laser Therapy of Benign Thyroid Nodules Unknown status NCT00150150 Phase 3
24 Prednisone Versus Doxycycline in the Treatment of Graves' Orbitopathy Unknown status NCT01809444 Phase 2, Phase 3 Prednisone+placebo of Doxycycline;Doxycycline+placebo of Prednisone
25 Effect of Percutaneous Botulinum Toxin A Injection on Natural Course of Upper Lid Retraction in Thyroid Eye Disease Unknown status NCT00370734 Phase 2, Phase 3 Botulinum toxin A injection
26 Clinical Trial on Harmonic Focus Shears Completed NCT01003652 Phase 2, Phase 3
27 Efficacy of Ropivacaine (With Epinephrine) in BABA Endoscopic and Robotic Thyroidectomy Completed NCT02112370 Phase 3 Ropivacaine with epinephrine injection
28 Comparison of Different Doses of 131I in Severe Graves' Hyperthyroidism Completed NCT01039818 Phase 3
29 Assessing the Impact of the Early and Systematic Hormonal Replacement After Radio-isotopic Ablation of Graves'hyperthyroïdism on Quality of Life, Efficiency and Tolerance Completed NCT01295333 Phase 3 the early prophylactic introduction of low dose of LT4 (50 µg/d) at 15 days post-ablation;The initiation of LT4 as soon as the first biological signs of hypothyroidism.
30 Treatment of Soft Tissue Expansion in Inactive Thyroid Eye Disease Patients Using Drops of Prostaglandin Analogues Completed NCT02155049 Phase 3 bimatoprost 0.03%
31 Tocilizumab Treatment in Graves´ Ophthalmopathy (Graves´ Orbitopathy or Thyroid Eye Disease) Completed NCT01297699 Phase 3 Tocilizumab (RoActemra®);Sterile 0.9% Sodium Chloride
32 Trial of Rituximab for Graves' Ophthalmopathy Completed NCT00595335 Phase 2, Phase 3 Rituximab;Saline;Methylprednisolone
33 Total Thyroidectomy Versus Thionamides in Patients With Moderate-to-Severe Graves' Ophthalmopathy Recruiting NCT03066076 Phase 3 Antithyroid Drug
34 Efficacy and Safety of Cholestyramine and Prednisolone as Adjunctive Therapy in Treatment of Overt Hyperthyroidism Recruiting NCT03303053 Phase 3 Cholestyramine Powder 4g;Prednisolone;Standard treatment
35 Treatment of Graves' Orbitopathy (Thyroid Eye Disease) to Reduce Proptosis With Teprotumumab Infusions in a Randomized, Placebo-Controlled, Clinical Study Recruiting NCT03298867 Phase 3
36 Treatment of Graves´Ophthalmopathy With Diclofenac or Simvastatin (GO-DS) Recruiting NCT03131726 Phase 3 Simvastatin 40mg;Diclofenac Potassium 50 MG
37 Bupivacaine Injection of Eye Muscles to Treat Strabismus Recruiting NCT01616108 Phase 2, Phase 3 Bupivacaine
38 The Effect of Intravenous Glucocorticoids on the Tearfilm in Eyes With Thyroid-associated Ophthalmopathy Recruiting NCT01579539 Phase 3 Methylprednisolone;Esomeprazole
39 Early Levothyroxine Post Radioactive Iodine Active, not recruiting NCT01950260 Phase 2, Phase 3 Levothyroxine
40 The Effect of a New Antioxidant Combination (ASTED) on Moderate to Severe Thyroid Eye Disease Not yet recruiting NCT02422368 Phase 2, Phase 3 Methylprednisolone + ASTED;Methylprednisolone +Placebo
41 The Effect of a New Antioxidant Combination (ASTED) on Mild Thyroid Eye Disease (TED) Not yet recruiting NCT02393183 Phase 2, Phase 3 ASTED
42 Doxycycline Treatment in Mild Graves' Orbitopathy Unknown status NCT02203682 Phase 2 Doxycycline;placebo
43 Role of the Microbiome in Graves' Orbitopathy Unknown status NCT02373995 Phase 1, Phase 2
44 Study to Determine the Dose, the Safety and Effectiveness of a New Drug, Modified Release rhTSH, in Patients With Multinodular Goiter Completed NCT00454220 Phase 2 MRrhTSH;MRrhTSH
45 rhTSH, Radioiodine Uptake and Goiter Reduction Following 131I Therapy in Patients With Benign Nontoxic Nodular Goiter Completed NCT00275171 Phase 2 Recombinant human thyrotropin (Thyrogen);recombinant human TSH
46 rhTSH, Thyroid Size, and Radioiodine Therapy in Benign Goiter Completed NCT00145366 Phase 2 Recombinant human thyrotropin (Thyrogen)
47 Health-Related Quality of Life for Thyroid Patients Completed NCT00150033 Phase 2
48 Efficacy of Subantimicrobial Dose Doxycycline for Moderate to Severe and Active Graves' Orbitopathy Completed NCT01727973 Phase 1, Phase 2 Doxycycline
49 Effects Of Oral Alfacalcidol On Maturation Of Dendritic Cells In Graves' Disease Patients Completed NCT02993302 Phase 2 1α-D3;Placebos
50 A Study to Evaluate the Safety and Effect of CFZ533 on Patients With Graves' Disease Completed NCT02713256 Phase 2 CFZ533

Search NIH Clinical Center for Goiter

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: goiter

Genetic Tests for Goiter

Genetic tests related to Goiter:

# Genetic test Affiliating Genes
1 Goiter 28

Anatomical Context for Goiter

MalaCards organs/tissues related to Goiter:

38
Thyroid, Eye, Bone, B Cells, Testes, T Cells, Breast

Publications for Goiter

Articles related to Goiter:

(show top 50) (show all 1640)
# Title Authors Year
1
iTRAQ analysis of urinary proteins: Potential use of gelsolin and osteopontin to distinguish benign thyroid goiter from papillary thyroid carcinoma. ( 29355489 )
2018
2
Genetic and functional analysis of two missense<i>DUOX2</i>mutations in congenital hypothyroidism and goiter. ( 29435108 )
2018
3
Indications for the Surgical Management of Benign Goiter in Adults. ( 29345225 )
2018
4
Evaluation of Four Variants of the Thyroid Imaging Reporting and Data System (TIRADS) Classification in Patients with Multinodular Goiter. ( 29334119 )
2018
5
Amyloid goiter mimicking subacute thyroiditis on clinical and imaging findings: A case report. ( 29315620 )
2018
6
The Iconography of Goiter: Five Sculptures in the Sacred Mountains of Varallo, Orta, and Varese in Italy. ( 29310524 )
2018
7
Effect of Goiter Dispersion Formula on Serum Cytokines in Hyperthyroidism Patients with Neurologic Manifestations of Graves' Disease: A Randomized Trial on 80 Cases. ( 29406821 )
2018
8
Obviating the need for sternotomy: Safety and effectiveness of microdebrider use for retrosternal goiter. ( 29360235 )
2018
9
Familial multinodular goiter and Sertoli-Leydig cell tumors associated with a large intragenic in-frame<i>DICER1</i>deletion. ( 29187512 )
2018
10
Extracorporeal Membrane Oxygenation (ECMO)-Assisted Surgery for Mediastinal Goiter Removal. ( 29242007 )
2018
11
Giant Cervical Goiter With Posterior Mediastinal Extension. ( 28929034 )
2017
12
Ten-Year Follow-Up of a Randomized Clinical Trial of Total Thyroidectomy Versus Dunhill Operation Versus Bilateral Subtotal Thyroidectomy for Multinodular Non-toxic Goiter. ( 28942461 )
2017
13
Correction: Urinary iodine concentration (UIC) could be a promising biomarker for predicting goiter among school-age children: A systematic review and meta-analysis. ( 28686699 )
2017
14
Intra-capsular total thyroid enucleation versus total thyroidectomy in treatment of benign multinodular goiter. A prospective randomized controlled clinical trial. ( 28728986 )
2017
15
Increased Chromosomal and Oxidative DNA Damage in Patients with Multinodular Goiter and Their Association with Cancer. ( 28373882 )
2017
16
Symptomatic Long Pauses and Bradycardia due to Massive Multinodular Goiter. ( 28845312 )
2017
17
Association between single nucleotide variants of vascular endothelial growth factor A and the risk of thyroid carcinoma and nodular goiter in a Han Chinese population. ( 28178662 )
2017
18
When Cardiopulmonary Bypass Is Not An Option-A Case of Massive Retrosternal Goiter With Severe Tracheal Compression in an Extremely Obese Patient. ( 29395824 )
2017
19
Poor dietary diversity, wealth status and use of un-iodized salt are associated with goiter among school children: a cross-sectional study in Ethiopia. ( 28061776 )
2017
20
Frequency of nodular goiter and autoimmune thyroid disease and association of these disorders with insulin resistance in polycystic ovary syndrome. ( 28400351 )
2017
21
Non-traumatic rupture of the superior thyroid artery with concomitant parathyroid adenoma and multinodular goiter. ( 28811931 )
2017
22
Associations between iodine intake, thyroid volume, and goiter rate in school-aged Chinese children from areas with high iodine drinking water concentrations. ( 27927635 )
2017
23
Tracheobronchopathia osteochondroplastica in recurrent retrosternal goiter. Surgical management. ( 28904244 )
2017
24
Airway Considerations in Case of a Large Multinodular Goiter. ( 29284884 )
2017
25
A rare case of poorly differentiated thyroid carcinoma probably arising from a nodular goiter. ( 28588422 )
2017
26
Treatment of Goiter with Traditional Chinese Medicine Regimen Xing Qi Hua Ying Tang: A Clinical Study on 72 Patients with Multinodular and Diffuse Goiter. ( 29215302 )
2017
27
The first serological evidence for Rift Valley fever infection in the camel, goitered gazelle and Anatolian water buffaloes in Turkey. ( 28861841 )
2017
28
Multinodular goiter: A study of malignancy risk in nondominant nodules. ( 28846789 )
2017
29
Prenatal diagnosis and successful intrauterine treatment of severe congenital hypothyroidism associated with fetal goiter. ( 27862717 )
2017
30
Higher urinary bisphenol A concentration and excessive iodine intake are associated with nodular goiter and papillary thyroid carcinoma. ( 28684549 )
2017
31
Successful combined surgical approach of a rare retrotracheal goiter in a patient with anatomical impediments. ( 28832090 )
2017
32
Correlation between serum lead and thyroid diseases: papillary thyroid carcinoma, nodular goiter, and thyroid adenoma. ( 28891673 )
2017
33
The Value of Preoperative Volumetric Analysis by Computerized Tomography of Retrosternal Goiter to Predict the Need for an Extracervical Approach. ( 28840845 )
2017
34
Molecular analysis of thyroglobulin mutations found in patients with goiter and hypothyroidism. ( 29275168 )
2017
35
A case of intravascular large B cell lymphoma presenting as nodular goiter. ( 28841887 )
2017
36
Low Iodine in the Follicular Lumen Caused by Cytoplasm Mis-localization of Sodium Iodide Symporter may Induce Nodular Goiter. ( 28190186 )
2017
37
Multiple Myeloma Presenting as Massive Amyloid Deposition in a Parathyroid Gland Associated with Amyloid Goiter: A Medullary Thyroid Carcinoma Mimic on Intra-operative Frozen Section. ( 28879586 )
2017
38
Medical geology of endemic goiter in Kalutara, Sri Lanka; distribution and possible causes. ( 28551882 )
2017
39
Role of intraoperative neuromonitoring of the recurrent laryngeal nerves during thyroid reoperations of recurrent goiter. ( 28703113 )
2017
40
Myasthenia Gravis, Mediastinal Goiter, and Crohn's Disease. ( 28528037 )
2017
41
Multinodular goiter in children: treatment controversies. ( 28749783 )
2017
42
Morbidity of total thyroidectomy for substernal goiter: A series of 70 patients. ( 28602544 )
2017
43
Risk Stratification in Multinodular Goiter: A Retrospective Review of Sonographic Features, Histopathological Results, and Cancer Risk. ( 28835334 )
2017
44
Prevalence of goiter and associated factors among schoolchildren in northeast Ethiopia. ( 29172409 )
2017
45
Quantification of Thyroid Cancer and Multinodular Goiter Risk in the DICER1 Syndrome: A Family-Based Cohort Study. ( 28323992 )
2017
46
Simultaneous unilateral anterior thoracoscopy with transcervical thyroidectomy for the resection of large mediastinal thyroid goiter. ( 28932554 )
2017
47
Patient-tailored management of an asymptomatic massive substernal goiter presenting as brachiocephalic vein occlusion. Report of a case and review of sternotomy indications. ( 28095343 )
2017
48
Increased Cardiovascular Mortality and Morbidity in Patients Treated for Toxic Nodular Goiter Compared to Graves' Disease and Nontoxic Goiter. ( 28471268 )
2017
49
Endemic goiter and iodine deficiency status among Guinea-Bissau school-age children. ( 29284787 )
2017
50
Thyroid hemiagenesis associated with multinodular goiter and Hashimoto's thyroiditis. ( 29442060 )
2017

Variations for Goiter

Expression for Goiter

Search GEO for disease gene expression data for Goiter.

Pathways for Goiter

GO Terms for Goiter

Biological processes related to Goiter according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cellular oxidant detoxification GO:0098869 9.67 DUOX2 IYD TPO TXNRD2
2 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007189 9.65 CALCA GNAS TSHR
3 positive regulation of cAMP biosynthetic process GO:0030819 9.63 CALCA GNAS TSHR
4 activation of adenylate cyclase activity GO:0007190 9.61 CALCA GNAS TSHR
5 hydrogen peroxide catabolic process GO:0042744 9.52 DUOX2 TPO
6 positive regulation of adenylate cyclase activity GO:0045762 9.51 CALCA TSHR
7 hormone biosynthetic process GO:0042446 9.5 DUOX2 TG TPO
8 cellular response to gonadotropin stimulus GO:0071371 9.49 PAX8 SLC5A5
9 thyroid hormone metabolic process GO:0042403 9.43 DUOX2 IYD TG
10 thyroid-stimulating hormone signaling pathway GO:0038194 9.4 PAX8 TSHR
11 iodide transport GO:0015705 9.33 SLC26A4 SLC5A5 TG
12 thyroid gland development GO:0030878 9.26 DUOX2 NKX2-1 PAX8 TG
13 thyroid hormone generation GO:0006590 8.92 DUOX2 IYD SLC5A5 TPO

Molecular functions related to Goiter according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.43 CALCA TG TRH
2 peroxidase activity GO:0004601 9.32 DUOX2 TPO
3 iodide transmembrane transporter activity GO:0015111 9.16 SLC26A4 SLC5A5
4 iodide peroxidase activity GO:0004447 8.96 IYD TPO
5 thyroid-stimulating hormone receptor activity GO:0004996 8.62 PAX8 TSHR

Sources for Goiter

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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