Aliases & Classifications for Goiter

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9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 33MeSH, 55SNOMED-CT, 27ICD9CM, 38NCIt
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Goiter, Aliases & Descriptions:

Name: Goiter 9 11 43 60
 
Goitre 9


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Disease Ontology9 DOID:12176
MeSH33 D006042
ICD9CM27 240.9
NCIt38 C26785

Summaries for Goiter

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Wikipedia:63 A goitre or goiter (see spelling differences; from the Latin gutteria, struma) is a swelling of the neck... more...

MalaCards based summary: Goiter, also known as goitre, is related to endemic goiter and thyroiditis. An important gene associated with Goiter is TG (thyroglobulin), and among its related pathways are Endothelin and Adenylate cyclase activating neuropeptides. The drugs thyroglobulin and thyroid (usp) and the compounds iodotyrosine and diiodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and testes, and related mouse phenotypes are tumorigenesis and limbs/digits/tail.

Disease Ontology:9 A thyroid gland disease that involves an abnormal enlargement of the thyroid gland.

Related Diseases for Goiter

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Diseases related to Goiter via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 254)
idRelated DiseaseScoreTop Affiliating Genes
1endemic goiter32.1TPO, TG, TSHR
2thyroiditis31.9TPO, TG, TSHR, CALCA
3graves' disease31.5TSHR, GNAS
4nodular goiter31.4TPO, TG, TSHR, LGALS3, CALCA
5toxic diffuse goiter31.3TPO, TG, TSHR
6multinodular goiter31.2SLC26A4, CALCA, TSHR, TG, TPO, GNAS
7plummer's disease31.2TPO, TG
8pendred syndrome31.1SLC26A4, TG, TPO
9goiter, multinodular 1, with or without sertoli-leydig cell tumors31.1TG, TPO
10autoimmune thyroiditis31.0TG, TPO
11nontoxic goiter31.0BGLAP, TPO, TG, TSHR
12thyrotoxicosis30.9TSHR, TG, TPO, THRB
13hypothyroidism30.8TPO, TG, TSHR, NKX2-1, SLC26A4
14leydig cell tumor30.7GNAS
15primary hyperparathyroidism30.7BGLAP, CALCA
16myxedema30.6TPO, TG, TSHR
17hyperparathyroidism30.6CALCA, BGLAP
18subacute thyroiditis30.6TG
19parathyroid adenoma30.5GNAS, LGALS3, CALCA
20sensorineural hearing loss30.5TPO, SLC26A4
21hyperthyroidism30.4THRB, BGLAP, GNAS, TPO, TG, TSHR
22thyroid hormone resistance30.3THRB, TG
23hyperthyroxinemia30.3TPO, TSHR
24addison's disease30.2TG, TPO
25mental retardation30.2THRB, GNAS, TSHR
26thyroid adenoma30.1LGALS3, TSHR, TG, TPO, GNAS
27congenital hypothyroidism30.1GNAS, TPO, TG, TSHR, NKX2-1
28paraganglioma30.1CALCA, TG
29acromegaly30.0GNAS, BGLAP
30teratoma30.0TG, NKX2-1
31struma ovarii29.9NKX2-1, TSHR, TG
32hypoparathyroidism29.9CALCA, BGLAP
33fibrous dysplasia29.9GNAS, BGLAP
34cushing's syndrome29.8BGLAP, GNAS, CALCA
35hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia29.6NKX2-1, LGALS3, TSHR, TG
36thyroid cancer29.6SLC26A4, NKX2-1, CALCA, LGALS3, TSHR, TG
37adenoma29.5THRB, GNAS, TPO, TG, TSHR, LGALS3
38papillary carcinoma29.2GNAS, SLC26A4, NKX2-1, CALCA, LGALS3, TSHR
39follicular adenoma29.0TSHR, TG, TPO, GNAS, LGALS3, CALCA
40substernal goiter10.8
41mediastinitis10.6
42cherubism10.5CALCA
43paget disease of bone10.5CALCA
44deafness, autosomal recessive 4, with enlarged vestibular aqueduct10.4SLC26A4
45pernicious anemia10.4TPO, TG
46hypothryoidism, congenital, nongoitrous 410.4TPO, TG
47lingual goiter10.4
48bird-headed dwarfism with progressive ataxia, insulin-resistant diabetes, goiter and primary gonadal insufficiency10.3
49blindness10.3
50hypothyroidism, congenital, nongoitrous, 110.3TSHR, GNAS

Graphical network of the top 20 diseases related to Goiter:



Diseases related to goiter

Symptoms for Goiter

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Drugs & Therapeutics for Goiter

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Genetic Tests for Goiter

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Anatomical Context for Goiter

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MalaCards organs/tissues related to Goiter:

31
Thyroid, Bone, Testes, Breast, Pituitary, Trachea, Lung, Endothelial, Lymph node, Cortex, Heart, Colon, Kidney, T cells, Bone marrow, Whole blood, Salivary gland, Ovary, Tonsil

Animal Models for Goiter or affiliated genes

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Publications for Goiter

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Articles related to Goiter:

(show top 50)    (show all 1469)
idTitleAuthorsYear
1
Decreased Expression of GPER1 Gene and Protein in Goiter. (25861267)
2015
2
Harlequin syndrome after thyroidectomy for compressive retrosternal goiter. Case report and review of the literature. (25102714)
2014
3
Efficacy of different protocols of radioiodine therapy for treatment of toxic nodular goiter: systematic review and meta-analysis of the literature. (24803943)
2014
4
Mediastinal goiter presenting with ventricular tachycardia. (22302698)
2013
5
Hemithyroidectomy Versus Dunhill for Surgical Treatment of Asymmetrical Multinodular Goiter. (24253155)
2013
6
Huge multinodular goiter with mid trachea obstruction: indication for fiberoptic intubation. (23330421)
2012
7
Preoperative a8^a8^mTc-sestamibi scintigraphy in patients with primary hyperparathyroidism and concomitant nodular goiter: comparison of SPECT-CT, SPECT, and planar imaging. (22825041)
2012
8
Monosomy and ring chromosome 13 in a thyroid nodular goiter-do we underestimate its relevance in benign thyroid lesions? (22469512)
2012
9
Multinodular goiter as the initial presentation of systemic sarcoidosis: limitation of fine-needle biopsy. (21352663)
2011
10
Genetics and phenomics of hypothyroidism and goiter due to NIS mutations. (20153805)
2010
11
Thyroid cancers amongst goiter population in a Nigerian tertiary hospital: surgical and radiographic perspective. (21526634)
2010
12
Perinatal goiter with increased iodine uptake and hypothyroidism due to excess maternal iodine ingestion. (19844123)
2009
13
Optimizing 131I uptake after rhTSH stimulation in patients with nontoxic multinodular goiter: evidence from a prospective, randomized, double-blind study. (19403877)
2009
14
Familial risks for hospitalized Graves' disease and goiter. (19661127)
2009
15
Serum hepatocyte growth factor is increased in Hashimoto's thyroiditis whether or not it is associated with nodular goiter as compared with healthy non-goitrous individuals. (19468262)
2009
16
Images in vascular medicine. A chronic compression of the upper mediastinal veins by a retrosternal goiter. (19651681)
2009
17
Does fine-needle aspiration cytology optimize the surgical management of thyroid disorders in endemic goiter region? (18202924)
2008
18
Radioiodine therapy for multinodular goiter. (22964127)
2008
19
Surgical excision of large multinodular goiter using an endoscopic transaxillary approach: a case report. (18936685)
2008
20
Normocalcemic, subclinical, asymptomatic primary hyperparathyroidism in patients with goiter or papillary thyroid cancer--preliminary report. Normocalcemic primary hyperparathyroidism and thyroid pathology. (17966885)
2007
21
C8orf4/TC-1 (thyroid cancer-1) gene expression in thyroid cancer and goiter. (17167272)
2007
22
Gender-specific determinants of goiter. (17194923)
2006
23
Complete inhibition of goiter in mice requires combined gene therapy modification of angiopoietin, vascular endothelial growth factor, and fibroblast growth factor signaling. (15817662)
2005
24
Total thyroidectomy for multinodular goiter. (9851343)
1998
25
Endemic goiter and thyroid function in central-southern Sardinia. Report on an extensive epidemiological survey. (7868805)
1994
26
Visualization of suppressed normal thyroid tissue by thallium-201 in patients with toxic nodular goiter. (3370895)
1988
27
Toxic multinodular goiter: a variant of autoimmune hyperthyroidism. (2888784)
1987
28
Pemphigus foliaceus coexisting with toxic, multinodular goiter. (3771047)
1986
29
Pilot study to detect neurologic disease in Ecuador among a population with a high prevalence of endemic goiter. (3831782)
1985
30
Sequestered substernal goiter. (6625801)
1983
31
Thyroid hormone and immunological studies in endemic goiter. (6309889)
1983
32
Pituitary thyroid recovery following surgery in TRH-unresponsive patients with uni- and multinodular goiter. (409657)
1977
33
Neonatal hypothyroidism and goiter in one infant of each of two sets of twins due to maternal therapy with antithyroid drugs. (4135477)
1974
34
Physical growth and development, neurological maturation and behavioral functioning in two Ecuadorian Andean communities in which goiter is endemic. I. Outline of the problem of endemic goiter and cretinism. Physical growth and neurological maturation in the adult population of La Esperanza. (4682523)
1973
35
Iodine metabolism in endemic goiter in Turkey. I. The kinetics of 131-I and organic iodine. (4125988)
1973
36
Iodine nutriture and prevalence of endemic goiter in USA. (4523766)
1973
37
Endemic goiter in Greece: nutritional status, growth, and skeletal development of goitrous and non goitrous populations. (4357119)
1973
38
I-131 treatment for toxic diffuse goiter. Analysis of 594 cases treated with repeated doses of 7 millicuries or less. (5281463)
1971
39
Electroencephalogram in juvenile endemic goiter and in acute goiter. (5113948)
1971
40
Nontoxic nodular goiter and carcinoma of the thyroid in children 15 years of age and younger. (6022975)
1967
41
Iodine deficiency in two endemic goiter areas of central and southern Italy. (4160409)
1966
42
A study on biosynthesis of iodoamino acids in the nodule and paranodular thyroid tissue in nontoxic nodular goiter with special reference to the application of paper chromatographic analysis using Na-I-131. (5913196)
1966
43
PROGNOSTIC VALUE OF 24-HOUR RADIOACTIVE IODINE UPTAKE; STUDIES IN PATIENTS WITH NODULAR GOITER AND DIFFUSE HYPERPLASTIC GOITER EIGHT TO TEN WEEKS FOLLOWING THERAPY WITH RADIOIODINE (I 131). (14160118)
1964
44
The thiocyanate suppression test--a new and simple test for differential diagnosis between hyperthyrodism and nontoxic goiter. (14496764)
1962
45
Prevention of endemic goiter in the Azerbaijan SSR]. (13675118)
1959
46
Endemic goiter. (13441193)
1957
47
Nodular goiter and carcinoma of the thyroid. (14368002)
1955
48
Endemic goiter in Latin America. (13134444)
1954
49
A Note on Chatin and the Hypothesis that Endemic Goiter is Due to a Lack of Iodine. (17810911)
1950
50
Iodine-lack theory and endemic goiter. (18901293)
1947

Variations for Goiter

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Expression for genes affiliated with Goiter

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Search GEO for disease gene expression data for Goiter.

Pathways for genes affiliated with Goiter

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Compounds for genes affiliated with Goiter

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Compounds related to Goiter according to GeneCards Suite gene sharing:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1iodotyrosine43 2411.2TG, TPO
2diiodotyrosine4310.2TPO, TG
3111in-pentetreotide4310.0TG, CALCA
4propylthiouracil43 2 1211.9TPO, TG, TSHR
5amiodarone43 49 28 1212.9TPO, TG, THRB
6125i439.9TPO, TG, TSHR
7perchlorate439.8SLC26A4, TG, TPO
8octreotide43 59 28 1212.7GNAS, TG, CALCA
9ipriflavone439.6CALCA, BGLAP
10calcium gluconate439.5BGLAP, CALCA
11asparagine439.5TSHR, GNAS, TPO
12triiodothyroacetic acid439.5THRB, BGLAP, TG
13carbimazole43 1210.4TSHR, TPO, BGLAP
1424,25-dihydroxyvitamin d3439.3CALCA, BGLAP
15acth439.3GNAS, TSHR, LGALS3, TPO
16sialic acid439.3TSHR, LGALS3, GNAS, TG
17alfacalcidol43 59 1211.3CALCA, BGLAP
18triiodothyronine439.2THRB, TG, TSHR, SLC26A4, TPO
19etidronate439.2CALCA, BGLAP
20guanine43 24 1211.2CALCA, TG, TSHR, THRB, GNAS
21methimazole43 2 1211.2BGLAP, TG, TSHR, TPO
22iodine43 2410.1GNAS, TSHR, SLC26A4, TG, TPO
23adenylate439.1GNAS, TPO, TG, CALCA, TSHR
24hydrocortisone43 2 59 1212.1TPO, CALCA, TG, BGLAP
25polysaccharide439.0GNAS, TPO, TG, TSHR, LGALS3
26teriparatide43 1210.0CALCA, BGLAP
27sodium iodide438.9TPO, TG, TSHR, NKX2-1, SLC26A4
28glutamine438.9TG, TSHR, LGALS3, GNAS
29iodide43 249.9NKX2-1, TG, SLC26A4, TPO, TSHR
30sodium43 249.8NKX2-1, TPO, SLC26A4, TG, TSHR
31forskolin43 49 1210.8GNAS, TPO, TSHR, CALCA, NKX2-1
32testosterone43 59 24 1211.7THRB, TG, CALCA, BGLAP, TPO
33vitamin d438.7LGALS3, BGLAP, CALCA, THRB
34glutamate438.6TG, LGALS3, TPO, TSHR, GNAS, CALCA
35ribonucleic acid438.6GNAS, THRB, TPO, NKX2-1, TSHR, TG
36nitric oxide43 24 1210.6SLC26A4, CALCA, GNAS, TPO, LGALS3
37progesterone43 28 59 24 1212.6GNAS, LGALS3, TSHR, THRB, NKX2-1
38oligonucleotide438.6GNAS, TSHR, LGALS3, NKX2-1, TPO
39threonine438.4THRB, GNAS, TSHR, LGALS3, NKX2-1
40h2o2438.4BGLAP, SLC26A4, LGALS3, TG, TPO
41vegf438.4BGLAP, TSHR, CALCA, LGALS3, TG
42paraffin438.3BGLAP, NKX2-1, LGALS3, TSHR, TG
43alanine438.2GNAS, TG, LGALS3, BGLAP, THRB, TSHR
44thyroxine43 249.0BGLAP, TPO, TG, SLC26A4, TSHR, CALCA
45arginine437.9LGALS3, THRB, TSHR, TG, TPO, GNAS
46cysteine437.9GNAS, TSHR, LGALS3, TPO, TG, THRB
47retinoic acid43 248.7TPO, NKX2-1, TSHR, LGALS3, BGLAP, THRB
48tyrosine437.6TG, TPO, TSHR, LGALS3, NKX2-1, SLC26A4
49estrogen437.6LGALS3, TSHR, NKX2-1, CALCA, TG, BGLAP
50serine437.5TSHR, LGALS3, TG, GNAS, BGLAP, THRB

GO Terms for genes affiliated with Goiter

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Cellular components related to Goiter according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dendriteGO:00304258.7DICER1, GNAS, BGLAP
2extracellular spaceGO:00056157.9CALCA, LGALS3, TG, TPO, BGLAP

Biological processes related to Goiter according to GeneCards Suite gene sharing:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:004244610.1TG, TPO
2thyroid hormone generationGO:000659010.1TG, TPO
3monocyte chemotaxisGO:00025489.7LGALS3, CALCA
4activation of adenylate cyclase activityGO:00071909.7GNAS, CALCA
5adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:00071899.7CALCA, GNAS
6thyroid gland developmentGO:00308789.7NKX2-1, TG
7embryonic hindlimb morphogenesisGO:00351169.6GNAS, DICER1
8positive regulation of cAMP biosynthetic processGO:00308199.4CALCA, GNAS
9bone developmentGO:00603489.1GNAS, BGLAP

Products for genes affiliated with Goiter

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Sources for Goiter

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet