MCID: GTR002
MIFTS: 62

Goiter malady

Genetic diseases (common), Endocrine diseases categories
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Summaries for Goiter

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Wikipedia:65 A goitre or goiter (see spelling differences; from the Latin gutteria, struma) is a swelling of the neck... more...

MalaCards based summary: Goiter is related to endemic goiter and thyroiditis. An important gene associated with Goiter is TG (thyroglobulin), and among its related pathways are Endothelin and Adenylate cyclase activating neuropeptides. The drugs methimazole and propylthiouracil and the compounds iodotyrosine and diiodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and testes, and related mouse phenotypes are tumorigenesis and limbs/digits/tail.

Disease Ontology:8 A thyroid gland disease that involves an abnormal enlargement of the thyroid gland.

Aliases & Classifications for Goiter

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt
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Goiter, Aliases & Descriptions:

Name: Goiter 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Endocrine diseases


External Ids:

Disease Ontology8 DOID:12176
MeSH34 D006042
ICD9CM27 240.9
NCIt39 C26785

Related Diseases for Goiter

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Diseases in the Goiter family:

Goiter, Familial, Due to Ttf-1 Defect

Diseases related to Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 212)
idRelated DiseaseScoreTop Affiliating Genes
1endemic goiter32.1TG, TPO, TSHR
2thyroiditis31.9TPO, TSHR, CALCA, TG
3graves' disease31.6GNAS, TSHR
4nodular goiter31.4TPO, TG, TSHR, LGALS3, CALCA
5toxic diffuse goiter31.3TG, TSHR, TPO
6multinodular goiter31.2GNAS, TPO, CALCA, SLC26A4, TSHR, TG
7plummer's disease31.2TG, TPO
8pendred syndrome31.1TPO, TG, SLC26A4
9nontoxic goiter31.0TSHR, TPO, BGLAP, TG
10autoimmune thyroiditis31.0TPO, TG
11thyrotoxicosis30.9TSHR, TPO, THRB, TG
12hypothyroidism30.8TSHR, SLC26A4, NKX2-1, TG, TPO
13leydig cell tumor30.7GNAS
14primary hyperparathyroidism30.7CALCA, BGLAP
15papillary thyroid carcinoma30.7TSHR, TPO, LGALS3, TG
16myxedema30.6TPO, TG, TSHR
17hyperparathyroidism30.6CALCA, BGLAP
18subacute thyroiditis30.6TG
19follicular thyroid carcinoma30.6TSHR, THRB, CALCA, TG
20parathyroid adenoma30.6CALCA, LGALS3, GNAS
21hyperthyroidism30.4THRB, GNAS, TSHR, TG, TPO, BGLAP
22hyperthyroxinemia30.3TPO, TSHR
23addison's disease30.2TPO, TG
24mental retardation30.2GNAS, THRB, TSHR
25paraganglioma30.1TG, CALCA
26thyroid adenoma30.1TSHR, GNAS, TG, LGALS3, TPO
27congenital hypothyroidism30.1TG, TPO, GNAS, TSHR, NKX2-1
28acromegaly30.0BGLAP, GNAS
29teratoma30.0TG, NKX2-1
30struma ovarii30.0NKX2-1, TG, TSHR
31hypoparathyroidism29.9CALCA, BGLAP
32fibrous dysplasia29.9BGLAP, GNAS
33adenoma29.5CALCA, GNAS, LGALS3, TSHR, TG, THRB
34papillary carcinoma29.3LGALS3, CALCA, NKX2-1, SLC26A4, TSHR, TG
35follicular adenoma29.0GNAS, TPO, TG, TSHR, LGALS3, CALCA
36substernal goiter10.8
37thyroid cancer10.7
38mediastinitis10.6
39cherubism10.5CALCA
40paget's disease of bone10.5CALCA
41neuroendocrine tumor10.5CALCA
42enlarged vestibular aqueduct10.4SLC26A4
43pernicious anemia10.4TPO, TG
44thyrotropin deficiency, isolated10.4TPO, TG
45thyroid hormone resistance syndrome10.4TG, THRB
46lingual goiter10.4
47pregnancy loss10.3TG, TPO
48blindness10.3
49mucoepidermoid carcinoma10.3CALCA, TG
50precocious puberty10.3GNAS, TSHR

Graphical network of the top 20 diseases related to Goiter:



Diseases related to goiter

Symptoms for Goiter

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Drugs & Therapeutics for Goiter

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Genetic Tests for Goiter

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Anatomical Context for Goiter

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MalaCards organs/tissues related to Goiter:

32
Thyroid, Bone, Testes, Pituitary, Breast, Trachea, Endothelial, Lymph node, Cortex, Heart, Colon, Kidney, Lung, T cells, Bone marrow, Whole blood, Salivary gland, Tonsil

Animal Models for Goiter or affiliated genes

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Publications for Goiter

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Articles related to Goiter:

(show top 50)    (show all 1442)
idTitleAuthorsYear
1
Harlequin syndrome after thyroidectomy for compressive retrosternal goiter. Case report and review of the literature. (25102714)
2014
2
Efficacy of different protocols of radioiodine therapy for treatment of toxic nodular goiter: systematic review and meta-analysis of the literature. (24803943)
2014
3
Mediastinal goiter presenting with ventricular tachycardia. (22302698)
2013
4
Hemithyroidectomy Versus Dunhill for Surgical Treatment of Asymmetrical Multinodular Goiter. (24253155)
2013
5
Huge multinodular goiter with mid trachea obstruction: indication for fiberoptic intubation. (23330421)
2012
6
Preoperative a8^a8^mTc-sestamibi scintigraphy in patients with primary hyperparathyroidism and concomitant nodular goiter: comparison of SPECT-CT, SPECT, and planar imaging. (22825041)
2012
7
Monosomy and ring chromosome 13 in a thyroid nodular goiter-do we underestimate its relevance in benign thyroid lesions? (22469512)
2012
8
Multinodular goiter as the initial presentation of systemic sarcoidosis: limitation of fine-needle biopsy. (21352663)
2011
9
Genetics and phenomics of hypothyroidism and goiter due to NIS mutations. (20153805)
2010
10
Thyroid cancers amongst goiter population in a Nigerian tertiary hospital: surgical and radiographic perspective. (21526634)
2010
11
Perinatal goiter with increased iodine uptake and hypothyroidism due to excess maternal iodine ingestion. (19844123)
2009
12
Optimizing 131I uptake after rhTSH stimulation in patients with nontoxic multinodular goiter: evidence from a prospective, randomized, double-blind study. (19403877)
2009
13
Familial risks for hospitalized Graves' disease and goiter. (19661127)
2009
14
Serum hepatocyte growth factor is increased in Hashimoto's thyroiditis whether or not it is associated with nodular goiter as compared with healthy non-goitrous individuals. (19468262)
2009
15
Images in vascular medicine. A chronic compression of the upper mediastinal veins by a retrosternal goiter. (19651681)
2009
16
Does fine-needle aspiration cytology optimize the surgical management of thyroid disorders in endemic goiter region? (18202924)
2008
17
Radioiodine therapy for multinodular goiter. (22964127)
2008
18
Surgical excision of large multinodular goiter using an endoscopic transaxillary approach: a case report. (18936685)
2008
19
Normocalcemic, subclinical, asymptomatic primary hyperparathyroidism in patients with goiter or papillary thyroid cancer--preliminary report. Normocalcemic primary hyperparathyroidism and thyroid pathology. (17966885)
2007
20
C8orf4/TC-1 (thyroid cancer-1) gene expression in thyroid cancer and goiter. (17167272)
2007
21
Gender-specific determinants of goiter. (17194923)
2006
22
Complete inhibition of goiter in mice requires combined gene therapy modification of angiopoietin, vascular endothelial growth factor, and fibroblast growth factor signaling. (15817662)
2005
23
Iodine and zinc, but not selenium and copper, deficiency exists in a male Turkish population with endemic goiter. (10468158)
1999
24
Total thyroidectomy for multinodular goiter. (9851343)
1998
25
Endemic goiter and thyroid function in central-southern Sardinia. Report on an extensive epidemiological survey. (7868805)
1994
26
Visualization of suppressed normal thyroid tissue by thallium-201 in patients with toxic nodular goiter. (3370895)
1988
27
Toxic multinodular goiter: a variant of autoimmune hyperthyroidism. (2888784)
1987
28
Pemphigus foliaceus coexisting with toxic, multinodular goiter. (3771047)
1986
29
Pilot study to detect neurologic disease in Ecuador among a population with a high prevalence of endemic goiter. (3831782)
1985
30
Sequestered substernal goiter. (6625801)
1983
31
Thyroid hormone and immunological studies in endemic goiter. (6309889)
1983
32
Pituitary thyroid recovery following surgery in TRH-unresponsive patients with uni- and multinodular goiter. (409657)
1977
33
Neonatal hypothyroidism and goiter in one infant of each of two sets of twins due to maternal therapy with antithyroid drugs. (4135477)
1974
34
Physical growth and development, neurological maturation and behavioral functioning in two Ecuadorian Andean communities in which goiter is endemic. I. Outline of the problem of endemic goiter and cretinism. Physical growth and neurological maturation in the adult population of La Esperanza. (4682523)
1973
35
Iodine metabolism in endemic goiter in Turkey. I. The kinetics of 131-I and organic iodine. (4125988)
1973
36
Iodine nutriture and prevalence of endemic goiter in USA. (4523766)
1973
37
Endemic goiter in Greece: nutritional status, growth, and skeletal development of goitrous and non goitrous populations. (4357119)
1973
38
I-131 treatment for toxic diffuse goiter. Analysis of 594 cases treated with repeated doses of 7 millicuries or less. (5281463)
1971
39
Electroencephalogram in juvenile endemic goiter and in acute goiter. (5113948)
1971
40
Nontoxic nodular goiter and carcinoma of the thyroid in children 15 years of age and younger. (6022975)
1967
41
Iodine deficiency in two endemic goiter areas of central and southern Italy. (4160409)
1966
42
A study on biosynthesis of iodoamino acids in the nodule and paranodular thyroid tissue in nontoxic nodular goiter with special reference to the application of paper chromatographic analysis using Na-I-131. (5913196)
1966
43
PROGNOSTIC VALUE OF 24-HOUR RADIOACTIVE IODINE UPTAKE; STUDIES IN PATIENTS WITH NODULAR GOITER AND DIFFUSE HYPERPLASTIC GOITER EIGHT TO TEN WEEKS FOLLOWING THERAPY WITH RADIOIODINE (I 131). (14160118)
1964
44
The thiocyanate suppression test--a new and simple test for differential diagnosis between hyperthyrodism and nontoxic goiter. (14496764)
1962
45
Prevention of endemic goiter in the Azerbaijan SSR]. (13675118)
1959
46
Endemic goiter. (13441193)
1957
47
Nodular goiter and carcinoma of the thyroid. (14368002)
1955
48
Endemic goiter in Latin America. (13134444)
1954
49
A Note on Chatin and the Hypothesis that Endemic Goiter is Due to a Lack of Iodine. (17810911)
1950
50
Iodine-lack theory and endemic goiter. (18901293)
1947

Variations for Goiter

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Expression for genes affiliated with Goiter

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Expression patterns in normal tissues for genes affiliated with Goiter

Search GEO for disease gene expression data for Goiter.

Pathways for genes affiliated with Goiter

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Compounds for genes affiliated with Goiter

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Compounds related to Goiter according to GeneCards/GeneDecks:

(show top 50)    (show all 96)
idCompoundScoreTop Affiliating Genes
1iodotyrosine44 2411.2TG, TPO
2diiodotyrosine4410.2TPO, TG
3111in-pentetreotide4410.0TG, CALCA
4propylthiouracil44 2 1111.9TPO, TG, TSHR
5amiodarone44 50 28 1112.9TPO, TG, THRB
6125i449.9TPO, TG, TSHR
7perchlorate449.8SLC26A4, TG, TPO
8octreotide44 61 28 1112.7GNAS, TG, CALCA
9ipriflavone449.6CALCA, BGLAP
10calcium gluconate449.5BGLAP, CALCA
11asparagine449.5TSHR, GNAS, TPO
12triiodothyroacetic acid449.5THRB, BGLAP, TG
13carbimazole44 1110.4TSHR, TPO, BGLAP
1424,25-dihydroxyvitamin d3449.3CALCA, BGLAP
15acth449.3GNAS, TSHR, LGALS3, TPO
16sialic acid449.3TSHR, LGALS3, GNAS, TG
17alfacalcidol44 61 1111.3CALCA, BGLAP
18triiodothyronine449.2THRB, TG, TSHR, SLC26A4, TPO
19etidronate449.2CALCA, BGLAP
20guanine44 24 1111.2CALCA, TG, TSHR, THRB, GNAS
21methimazole44 2 1111.2BGLAP, TG, TSHR, TPO
22iodine44 2410.1GNAS, TSHR, SLC26A4, TG, TPO
23adenylate449.1GNAS, TPO, TG, CALCA, TSHR
24hydrocortisone44 2 61 1112.1TPO, CALCA, TG, BGLAP
25polysaccharide449.0GNAS, TPO, TG, TSHR, LGALS3
26teriparatide44 1110.0CALCA, BGLAP
27sodium iodide448.9TPO, TG, TSHR, NKX2-1, SLC26A4
28glutamine448.9TG, TSHR, LGALS3, GNAS
29iodide44 249.9NKX2-1, TG, SLC26A4, TPO, TSHR
30sodium44 249.8NKX2-1, TPO, SLC26A4, TG, TSHR
31forskolin44 50 1110.8GNAS, TPO, TSHR, CALCA, NKX2-1
32testosterone44 61 24 1111.7THRB, TG, CALCA, BGLAP, TPO
33vitamin d448.7LGALS3, BGLAP, CALCA, THRB
34glutamate448.6TG, LGALS3, TPO, TSHR, GNAS, CALCA
35ribonucleic acid448.6GNAS, THRB, TPO, NKX2-1, TSHR, TG
36nitric oxide44 24 1110.6SLC26A4, CALCA, GNAS, TPO, LGALS3
37progesterone44 28 61 24 1112.6GNAS, LGALS3, TSHR, THRB, NKX2-1
38oligonucleotide448.6GNAS, TSHR, LGALS3, NKX2-1, TPO
39threonine448.4THRB, GNAS, TSHR, LGALS3, NKX2-1
40h2o2448.4BGLAP, SLC26A4, LGALS3, TG, TPO
41vegf448.4BGLAP, TSHR, CALCA, LGALS3, TG
42paraffin448.3BGLAP, NKX2-1, LGALS3, TSHR, TG
43alanine448.2GNAS, TG, LGALS3, BGLAP, THRB, TSHR
44thyroxine44 249.0BGLAP, TPO, TG, SLC26A4, TSHR, CALCA
45arginine447.9LGALS3, THRB, TSHR, TG, TPO, GNAS
46cysteine447.9GNAS, TSHR, LGALS3, TPO, TG, THRB
47retinoic acid44 248.7TPO, NKX2-1, TSHR, LGALS3, BGLAP, THRB
48tyrosine447.6TG, TPO, TSHR, LGALS3, NKX2-1, SLC26A4
49estrogen447.6LGALS3, TSHR, NKX2-1, CALCA, TG, BGLAP
50serine447.5TSHR, LGALS3, TG, GNAS, BGLAP, THRB

GO Terms for genes affiliated with Goiter

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Cellular components related to Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dendriteGO:0304258.7DICER1, GNAS, BGLAP
2extracellular spaceGO:0056157.9CALCA, LGALS3, TG, TPO, BGLAP

Biological processes related to Goiter according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1hormone biosynthetic processGO:04244610.1TG, TPO
2thyroid hormone generationGO:00659010.1TG, TPO
3monocyte chemotaxisGO:0025489.7LGALS3, CALCA
4activation of adenylate cyclase activityGO:0071909.7GNAS, CALCA
5adenylate cyclase-activating G-protein coupled receptor signaling pathwayGO:0071899.7CALCA, GNAS
6thyroid gland developmentGO:0308789.7NKX2-1, TG
7embryonic hindlimb morphogenesisGO:0351169.6GNAS, DICER1
8positive regulation of cAMP biosynthetic processGO:0308199.4CALCA, GNAS
9bone developmentGO:0603489.1GNAS, BGLAP

Products for genes affiliated with Goiter

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  • Antibodies
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Sources for Goiter

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet