MCID: GTR002
MIFTS: 61

Goiter malady

Summaries for Goiter

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 A goitre or goiter (Latin gutteria, struma), is a swelling of the neck or larynx resulting from... more...

MalaCards: Goiter is related to thyroiditis and endemic goiter. An important gene associated with Goiter is TG (thyroglobulin), and among its related pathways are Class A/1 (Rhodopsin-like receptors) and Allograft rejection. The drugs methimazole and propylthiouracil and the compounds tyrosine and arginine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and bone, and related mouse phenotypes are homeostasis/metabolism and nervous system.

Disease Ontology:8 A thyroid gland disease that involves an abnormal enlargement of the thyroid gland.

Aliases & Classifications for Goiter

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM
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Aliases & Descriptions:

goiter 8 10 44 60


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Disease Ontology8 DOID:12176
MeSH34 D006042
NCIt39 C26785
ICD9CM27 240.9

Related Diseases for Goiter

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17GeneCards, 18GeneDecks
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Diseases in the Goiter family:

Goiter, Familial, Due to Ttf-1 Defect

Diseases related to Goiter via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 251)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.6TG, TPO, CALCA, TRH, SERPINA7, TSHR
2endemic goiter31.6TSHR, TPO, TG
3multinodular goiter31.5SLC26A4, KRT19, TSHR, ADCY10, TPO, TG
4nodular goiter31.5TPO, TG, TSHR, LGALS3, KRT19, CALCA
5nontoxic goiter31.2BGLAP, TSHR, TPO, TG
6hypothyroidism31.0NKX2-1, TRH, SLC26A4, TSHR, TPO, TG
7graves' disease31.0TSHR, GNAS
8thyroid cancer30.9CALCA, GNAS, NKX2-1, TRH, THRB, SLC26A4
9hyperthyroidism30.9TPO, TG, ADCY10, TSHR, SERPINA7, BGLAP
10toxic diffuse goiter30.9TSHR, TPO, TG
11adenoma30.7CALCA, GNAS, NKX2-1, TRH, IL6R, THRB
12papillary carcinoma30.7TG, TPO, CALCA, GNAS, NKX2-1, SLC26A4
13pendred syndrome30.7SLC26A4, TPO, TG
14papillary thyroid carcinoma30.7TG, TPO, TSHR, LGALS3
15thyrotoxicosis30.6TRH, THRB, SERPINA7, TSHR, TPO, TG
16congenital hypothyroidism30.6GNAS, NKX2-1, SERPINA7, TSHR, TPO, TG
17autoimmune thyroiditis30.6CALCA, TPO, TG
18hyperparathyroidism30.5ADCY10, CALCA, BGLAP
19plummer's disease30.5TG, TPO, ICAM1
20follicular thyroid carcinoma30.4CALCA, THRB, TSHR, ADCY10, TG
21parathyroid adenoma30.3LGALS3, GNAS, CALCA
22thyroid medullary carcinoma30.2CALCA, NKX2-1, LGALS3, TG
23myxedema30.1TSHR, TPO, TG
24acromegaly30.0ADCY10, TRH, GNAS, BGLAP
25follicular adenoma30.0KRT19, LGALS3
26arthritis30.0IL6R, ICAM1, CALCA, BGLAP
27rheumatoid arthritis30.0IL6R, ICAM1, BGLAP
28thymoma29.9NKX2-1
29mccune albright syndrome29.9GNAS
30leydig cell tumor29.9ADCY10, GNAS
31breast cancer29.7CALCA, IL6R, THRB, KRT19, LGALS3, ADCY10
32hyperthyroxinemia29.7TRH, SERPINA7, TSHR, TPO
33thyroid hormone resistance syndrome29.7TRH, THRB, SERPINA7, TG
34obesity29.7GNAS, TRH, IL6R, ADCY10
35subacute thyroiditis29.7TPO, TSHR, TG
36melanoma29.7TSHR, LGALS3, NKX2-1, ICAM1
37struma ovarii29.7NKX2-1, TSHR, TG
38paraganglioma29.7TG, CALCA
39pancreatitis29.7ICAM1
40lung cancer29.7KRT19, NKX2-1
41fibrous dysplasia29.7BGLAP, GNAS, ADCY10
42adenocarcinoma29.7ADCY10, LGALS3, KRT19, NKX2-1
43hypoparathyroidism29.7CALCA, BGLAP
44addison's disease29.7TPO, TG
45tuberculosis29.7GSR, TPO, ADCY10
46myocardial infarction29.7IL6R, TPO, GSR
47amenorrhea29.7TRH
48ischemia29.7ICAM1, IL6R, LGALS3, GSR
49substernal goiter10.7
50mediastinitis10.5

Graphical network of the top 20 diseases related to Goiter:



Diseases related to goiter

Clinical Features for Goiter

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Drugs & Therapeutics for Goiter

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Goiter

Drug clinical trials:

Search ClinicalTrials for Goiter

Search NIH Clinical Center for Goiter

Search CenterWatch for Goiter

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Goiter

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Anatomical Context for Goiter

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32MalaCards
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MalaCards organs/tissues related to Goiter:

32
Thyroid, Testes, Bone, Pituitary, Trachea, Breast, Endothelial, Heart, Kidney, Colon, Lymph node, T cells, Lung, Cortex, Salivary gland, Tonsil, Whole blood

Animal Models for Goiter or affiliated genes

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36MGI
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Publications for Goiter

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50PubMed
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Articles related to Goiter:

(show top 50)    (show all 1408)
idTitleAuthorsYear
1
Mediastinal goiter presenting with ventricular tachycardia. (22302698)
2013
2
The prevalence of TSH receptor germline mutations and clinical courses in 89 hyperthyroid patients with diffuse goiter and negative anti-TSH receptor antibodies. (24279482)
2013
3
IONM-guided goiter surgery leading to two-stage thyroidectomy--indication and results. (23179319)
2013
4
A case of fetal goiter that resolved spontaneously after birth. (23979952)
2013
5
Goiter frequency is more strongly associated with gastric adenocarcinoma than urine iodine level. (23844325)
2013
6
Nodular goiter with multiple cystic and solid swellings. (22837936)
2012
7
Selenium deficiency a factor in endemic goiter persistence in sub-Saharan Africa. (21523503)
2011
8
Amyloid goiter: first manifestation of systemic amyloidosis. (20822765)
2010
9
Thyroid hemiagenesis with multinodular goiter: a case presentation and review of literature. (21225789)
2010
10
Fetal goiter mimicking anomalous pulmonary venous connection. (21087438)
2010
11
Genetic causes of goiter and deafness: Pendred syndrome in a girl and cooccurrence of Pendred syndrome and resistance to thyroid hormone in her sister. (19318451)
2009
12
C8orf4/TC-1 (thyroid cancer-1) gene expression in thyroid cancer and goiter. (17167272)
2007
13
Recurrence of the p.R277X/p.R1511X compound heterozygous mutation in the thyroglobulin gene in unrelated families with congenital goiter and hypothyroidism: haplotype analysis using intragenic thyroglobulin polymorphisms. (17911408)
2007
14
LigaSure vs clamp-and-tie technique to achieve hemostasis in total thyroidectomy for benign multinodular goiter: a prospective randomized study. (17309966)
2007
15
Evaluation of endemic goiter prevalence in Bulgarian schoolchildren: results from national strategies for prevention and control of iodine-deficiency disorders. (17709907)
2007
16
Comparison of surgical techniques for treatment of benign toxic multinodular goiter. (15951930)
2005
17
Subcorneal pustular dermatosis developing in a patient with rheumatoid arthritis; rheumatoid, antimicrosomal, and antimitochondrial autoantibodies; and a goiter. (14673283)
2003
18
Pretreatment with a single, low dose of recombinant human thyrotropin allows dose reduction of radioiodine therapy in patients with nodular goiter. (12843153)
2003
19
Endemic goiter in pregnant women: utility of the simplified classification of thyroid size by palpation and urinary iodine as screening tests. (12504972)
2002
20
Pregnancy and multinodular goiter. (12150346)
2002
21
A randomized trial comparing levothyroxine with radioactive iodine in the treatment of sporadic nontoxic goiter. (11238476)
2001
22
Increased major histocompatibility complex (MHC) expression in nontoxic goiters is associated with iodide depletion, enhanced ability of the follicular thyroglobulin to increase MHC gene expression, and thyroid autoantibodies. (10690902)
2000
23
Thyroxine prophylaxis after bilateral subtotal thyroidectomy for multinodular goiter. (11036880)
2000
24
Total thyroidectomy for bilateral benign multinodular goiter: effect of changing practice. (10593340)
1999
25
F-18-FDG PET in autonomous goiter]. (9987775)
1999
26
The predominant form of non-toxic goiter in Greece is now autoimmune thyroiditis. (10366406)
1999
27
A single amino acid change in the acetylcholinesterase-like domain of thyroglobulin causes congenital goiter with hypothyroidism in the cog/cog mouse: a model of human endoplasmic reticulum storage diseases. (9707574)
1998
28
Iodide or L-thyroxine to prevent recurrent goiter in an iodine-deficient area: prospective sonographic study. (8943171)
1997
29
Familial nontoxic multinodular thyroid goiter locus maps to chromosome 14q but does not account for familial nonmedullary thyroid cancer. (9345104)
1997
30
Identification of constitutively activating somatic thyrotropin receptor mutations in a subset of toxic multinodular goiters. (9398745)
1997
31
Clinical and morphologic findings of familial goiter in bongo antelope (Tragelaphus eurycerus). (7604491)
1995
32
Papillary carcinoma in a huge intrathoracic goiter with tracheal stenosis and invasion. Case report. (8197431)
1993
33
Individual difference in toxic diffuse goiters assessed by heme-based specific activity and Km value. (7951488)
1993
34
Circadian rhythms in urinary trace element and electrolyte excretion in children with and without endemic goiter. (2631179)
1989
35
Circadian and circannual variations of thyroid function in children 11 +/- 1.5 years of age with and without endemic goiter. (3628335)
1987
36
Surgical indications in endemic goiter. Pre- and postoperative care. (6172835)
1981
37
The increasing incidence of hypothyroidism within one year after radioiodine therapy for toxic diffuse goiter. (627898)
1978
38
Multinodular goiter with substernal component causing superior vena cava obstruction. (869733)
1977
39
Hand skeletal development among Ecuadorians living under conditions of iodine deficiency and endemic goiter. (1278713)
1976
40
Endemic goiter and antithyroid agents. (49867)
1975
41
Taste sensitivity to phenylthiocarbamide (PTC) and endemic goiter in the Indian natives of Peruvian highlands. (5120557)
1971
42
The case for thyroidectomy for nodular goiter. (5774433)
1969
43
Profile of nodular goiter. (5715495)
1968
44
Nontoxic nodular goiter and carcinoma of the thyroid in children 15 years of age and younger. (6022975)
1967
45
Unusual familial goiter associated with intrathyroidal calcification. (4162574)
1966
46
Nodular goiter: incidence, treatment and results. (13784190)
1961
47
Endemic goiter and nutrition. II. A follow-up study of 75 families in a Brazilian Amazon community. (13649625)
1959
48
Incidence of malignancy in toxic and nontoxic nodular goiter. (13151843)
1954
49
The problem of endemic goiter. (13032683)
1953
50
Nodular goiter; factors influencing therapy. (20253986)
1947

Genetic Variations for Goiter

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Expression for genes affiliated with Goiter

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Goiter

Search GEO for disease gene expression data for Goiter.

Pathways for genes affiliated with Goiter

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53Reactome, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Goiter according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.6THRB, TSHR, GNAS, CALCA, TRH
2
Hide members
10.5TG, TPO, TSHR
3
Hide members
10.5TPO, GSR, TG
410.5GNAS, ADCY10, CALCA
5
Transcription Role of VDR in regulation of genes involved in osteoporosis
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10.5BGLAP, THRB, CALCA

Compounds for genes affiliated with Goiter

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44Novoseek, 24HMDB, 2BitterDB, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 49PharmGKB
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Compounds related to Goiter according to GeneCards/GeneDecks:

(show top 50)    (show all 105)
idCompoundScoreTop Affiliating Genes
1tyrosine4411.1THRB, SLC26A4, KRT19, LGALS3, SERPINA7, TSHR
2arginine4411.1IL6R, BGLAP, ADCY10, TSHR, SERPINA7, LGALS3
3thyroxine44 2412.1BGLAP, CALCA, TRH, THRB, TG, GSR
4ribonucleic acid4411.1THRB, IL6R, NKX2-1, GNAS, KRT19, SERPINA7
5iodine44 2412.0TPO, TSHR, SERPINA7, TG, GNAS, TRH
6methimazole44 2 1113.0GSR, BGLAP, ICAM1, TRH, SERPINA7, TSHR
7retinoic acid44 2412.0TSHR, TPO, TG, THRB, LGALS3, IL6R
8triiodothyronine4411.0TPO, TSHR, TG, SERPINA7, SLC26A4, THRB
9guanine44 11 2413.0ICAM1, THRB, TSHR, ADCY10, TG, CALCA
10progesterone44 59 28 11 2415.0TSHR, TRH, NKX2-1, KRT19, SERPINA7, LGALS3
11testosterone44 59 11 2414.0TG, IL6R, TPO, SERPINA7, KRT19, THRB
12adenylate4411.0CALCA, ADCY10, TPO, GSR, TG, GNAS
13sodium iodide4411.0NKX2-1, SLC26A4, TPO, TSHR, TG
14iodide44 2412.0SERPINA7, SLC26A4, TG, NKX2-1, TPO
15acth4411.0TRH, LGALS3, TPO, SERPINA7, TSHR, GNAS
16creatinine4411.0GSR, TPO, IL6R, KRT19, BGLAP, TG
17estrogen4411.0TRH, TG, TSHR, SERPINA7
18vegf4411.0TSHR, KRT19, LGALS3, IL6R, ICAM1, BGLAP
19octreotide44 59 28 1114.0TG, ADCY10, TRH, GNAS, CALCA
20alanine4411.0GSR, THRB, TSHR, SERPINA7, LGALS3, GNAS
21aspartate4410.9TSHR, SERPINA7, KRT19, BGLAP, TPO, GSR
22polysaccharide4410.9LGALS3, TG, TSHR, ICAM1, GNAS, TPO
23amiodarone44 49 28 1113.9TG, TPO, SERPINA7, THRB
24125i4410.9TSHR, SERPINA7, TG, TPO
25glutamate4410.9TPO, GNAS, TRH
26triiodothyroacetic acid4410.9THRB, BGLAP, TG
27hydrocortisone44 2 59 1113.9TG, BGLAP, CALCA, TRH, TPO
28forskolin44 49 1112.9CALCA, NKX2-1, TSHR
29sialic acid4410.9LGALS3, TG, GNAS, TSHR, SERPINA7
30perchlorate4410.9SLC26A4, TPO, TG
31cysteine4410.9TG, TSHR, TPO, GSR, THRB, GNAS
3224,25-dihydroxyvitamin d34410.9CALCA, BGLAP, ADCY10
33h2o24410.9SLC26A4, BGLAP, TPO, LGALS3, ICAM1
34carbimazole44 1111.9BGLAP, TSHR, TPO
35paraffin4410.8LGALS3, BGLAP, NKX2-1, KRT19, TG, TSHR
36clonidine44 28 1112.8ADCY10, TRH, BGLAP, CALCA
37steroid4410.8TPO, SERPINA7, THRB, NKX2-1, IL6R, GNAS
38cycloheximide4410.8TRH, ADCY10
39oligonucleotide4410.8TRH, NKX2-1, IL6R, LGALS3, TSHR, TPO
40estradiol44 11 2412.8TRH, SERPINA7, TSHR
41sodium fluoride4410.7ADCY10, CALCA, BGLAP
42lactate4410.7TG, GSR, LGALS3, KRT19, ICAM1, CALCA
43gnrh4410.7TRH, BGLAP, GNAS, NKX2-1, GSR
44propylthiouracil44 2 1112.7TG
45Liothyronine11 2411.6TPO, SERPINA7, THRB
46serine4410.6NKX2-1, GNAS, BGLAP, KRT19, TSHR, THRB
47thymidine44 2411.6GNAS, TRH, IL6R, KRT19, TSHR, TG
48ascorbic acid44 2411.6ICAM1, BGLAP, TG, TPO, GSR
49chromium4410.4GSR, TG, TPO
50asparagine4410.2GNAS, TPO, TSHR, SERPINA7

GO Terms for genes affiliated with Goiter

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16Gene Ontology
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Cellular components related to Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6BGLAP, CALCA, GNAS, TRH, IL6R, SERPINA7
2extracellular spaceGO:00561510.3BGLAP, CALCA, ICAM1, IL6R, SERPINA7, TG

Biological processes related to Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to ethanolGO:04547110.6TRH, ICAM1, BGLAP
2thyroid hormone generationGO:00659010.5TG, TPO
3cAMP biosynthetic processGO:00617110.5ADCY10, GNAS
4response to drugGO:04249310.4BGLAP, GNAS, ICAM1, SERPINA7
5hormone biosynthetic processGO:04244610.2TG, TPO

Molecular functions related to Goiter according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1adenylate cyclase activityGO:00401610.5ADCY10, GNAS

Products for genes affiliated with Goiter

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  • Antibodies
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Sources for Goiter

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet