Goiter malady

Wikipedia: A goitre or goiter (Latin gutteria, struma), is a swelling of the thyroid gland, which can lead to a...⁴⁴ more...

MalaCards: Goiter is related to multinodular goiter and nodular goiter. An important gene associated with Goiter is TG (thyroglobulin), and among its related pathways are Renal cell carcinoma and Graft-versus-host disease. The drugs methimazole and thyroglobulin and the compounds iodide and ly294002 have been mentioned in the context of this disorder. Affiliated tissues include thyroid, t cells and endothelial, and related mouse phenotypes are hematopoietic system and limbs/digits/tail.

Disease Ontology: A thyroid gland disease that involves an abnormal enlargement of the thyroid gland.⁶

Aliases & Descriptions:

goiter 6 7 8 32 43

Diseases related to goiter by text searches and GeneDecks gene sharing:

(show top 50)    (show all 863)

id	Related Disease	Score	Top Affiliating Genes
1	multinodular goiter	35.8	NAALADL1, VHL, VEGFA, LEP, MNG1, MNG2
2	nodular goiter	35.0	GSR, IL6R, IFNG, ICAM1, CALCA, TRH
3	endemic goiter	34.9	SERPINA7, IGFBP3, TRH, TPO, TSHR, TG
4	hypothyroidism	34.6	LEP, IGFBP3, TRH, TPO, SHBG, LSL
5	pendred syndrome	34.2	PAX8, TPO, DUOX2, DIO2, TG, SLC26A4
6	nontoxic goiter	34.1	BGLAP, FASLG, TRH, TPO, TSHR, TG
7	thyroid cancer	32.7	RET, BRAF, PAX8, LGALS3, S100A4, HSPG2
8	toxic diffuse goiter	32.6	TPO, TSHR, TG, TDG
9	plummer's disease	32.5	SELE, SELL, ICAM1, TPO, SHBG, TG
10	autoimmune thyroiditis	31.2	RET, SERPINA7, BRAF, LMOD1, LGALS3, CIITA
11	thyroid adenoma	29.8	RET, SERPINA7, BRAF, BGLAP, LGALS3, GNAS
12	papillary thyroid carcinoma	28.7	RET, BRAF, VEGFC, PAX8, LGALS3, S100A4
13	follicular adenoma	28.3	RET, LGALS3, S100A4, IL6R, TPO, PTEN
14	primary hyperparathyroidism	28.1	RET, BGLAP, ALPP, CALCA, PTH
15	thyroid carcinoma	27.9	RET, SELE, SELL, BRAF, VHL, VEGFA
16	congenital hypothyroidism	27.9	SERPINA7, BGLAP, PAX8, P4HB, XBP1, IYD
17	leydig cell tumor	27.4	CGA, INSL3, ALPP, GNAS, PTH, DICER1
18	graves' disease	27.0	SELE, SELL, SERPINA7, LMOD1, BGLAP, PAX8
19	renal cell carcinoma	25.1	RET, BRAF, VHL, VEGFA, VEGFC, PAX8
20	hyperthyroidism	22.8	SELE, SELL, SERPINA7, LPO, LMOD1, BGLAP
21	thyroiditis	21.7	PIGF, RET, RBP4, SELE, SERPINA7, NAALADL1
22	hyperparathyroidism	21.3	RET, SELE, VEGFA, BGLAP, LEP, INS
23	blindness	20.0	RBP4, SELE, SERPINA7, VEGFA, BGLAP, LEP
24	adenoma	20.0	RET, SERPINA7, BRAF, VHL, VEGFA, VEGFC
25	carcinoma	18.7	PIGF, RET, RBP4, SELE, SELL, SERPINA7
26	anaplastic carcinoma	14.2	RET, BRAF, PAX8, LGALS3, S100A4, CALCA
27	mucinoses	14.2	SERPINA7, TRH, TPO, TSHR, TG
28	thyroid agenesis	14.2	SERPINA7, PAX8, LGALS3, TSHR, TG, NKX2-1
29	neonatal hypothyroidism	14.2	PAX8, TPO, TSHR, TG, SLC5A5, ADCY10
30	struma ovarii	14.2	RET, BRAF, TSHR, TG, NKX2-1
31	subacute thyroiditis	14.1	TPO, TSHR, TG
32	myxedema	14.1	TPO, CTLA4, TSHR, TG
33	limbic encephalitis	14.1	GSR, IFNG, TPO, TG
34	nonencapsulated sclerosing carcinoma	14.0	RET, BRAF, VEGFC, PAX8, LGALS3, S100A4
35	neurocirculatory asthenia	14.0	GSR, IL1B, HSPG2, CAT, TSHR, SOD1
36	mumps	14.0	IL1B, IFNG, ICAM1, TPO, TG, CXCL10
37	diabetic cataract	14.0	GSR, CAT, G6PD, SOD1, CP
38	neonatal thyrotoxicosis	14.0	TXNRD2, TRH, TSHR
39	bronchitis	14.0	SELL, LEP, GNAS, TRH, SHBG, TGFB2
40	pulmonary plasma cell granuloma	13.9	CIITA, CD28, CD86, CD80, IFNG, CAT
41	allergic encephalomyelitis	13.9	CIITA, CD86, CD80, FASLG, IFNG, ICAM1
42	familial hypothyroidism	13.9	PAX8, TSHB, NKX2-1
43	allergic contact dermatitis of eyelid	13.9	SELE, IL1B, IFNG, ICAM1, CALCA, CXCL10
44	aseptic meningitis	13.9	IL1B, IFNG, CAT, G6PD, SOD1
45	contact dermatitis	13.9	SELE, IL1A, IL1B, IFNG, ICAM1, CALCA
46	complex regional pain syndrome	13.9	LPO, IL1A, IL1B, IFNG, CALCA, SOD1
47	cerebral malaria	13.9	SELE, IL1A, IL1B, IFNG, ICAM1, G6PD
48	eales disease	13.9	VEGFA, IFNG, SOD1, CP
49	thyroid cancer, follicular	13.9	CALCA, PTEN, TSHR, THRB, TG, ADCY10
50	allergic conjunctivitis	13.9	IFNG, ICAM1, TNFRSF9, SOD1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 levothyroxine, levothyroxine sodium, liothyronine, liothyronine sodium, methimazole, propylthiouracil, thyroglobulin, thyroid, thyroid pwdr [va product], thyroid,bovine

MalaCards organs/tissues related to goiter:

²²

MGI Mouse Phenotypes related to goiter:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.0	BRAF, VHL, LGALS3, XBP1, CD28, CD86
2	limbs/digits/tail phenotype	MP:0005371	9.2	ESR2, PTH, DICER1, THRB, TGFB2, TGFB3
3	no phenotypic analysis	MP:0003012	9.0	TNFRSF4, TNFRSF9, DICER1, SST, KRT19, THRB
4	endocrine/exocrine gland phenotype	MP:0005379	9.0	ACVR1B, TKT, DPP4, TFCP2L1, SLC26A4, SLC5A8
5	integument phenotype	MP:0010771	8.9	TNFRSF9, HRAS, CALCA, HSPA5, DICER1, CTLA4
6	embryogenesis phenotype	MP:0005380	8.8	DICER1, KRT19, ACVR2B, ACVR2A, ACVR1B, G6PD
7	renal/urinary system phenotype	MP:0005367	8.7	RET, BRAF, VHL, PAX8, INHBA, INS
8	hearing/vestibular/ear phenotype	MP:0005377	8.7	DUOX2, ACVR1, TSHR, THRB, TGFB2, SOD1
9	liver/biliary system phenotype	MP:0005370	8.5	VEGFA, XBP1, INS, MET, IL2, IFNG
10	reproductive system phenotype	MP:0005389	8.4	INSL3, FASLG, IFNG, ALPP, HSPA5, HRAS
11	immune system phenotype	MP:0005387	8.3	FGFR1, IL2, IL6R, MAF, IFNG, GNAS
12	adipose tissue phenotype	MP:0005375	8.2	TKT, PTEN, DUOX2, GH1, ESR2, GNAS
13	skeleton phenotype	MP:0005390	8.0	DUOX2, PTEN, PTH, CTLA4, PLA2G6, KRT19
14	tumorigenesis	MP:0002006	7.9	PTEN, ESR2, HRAS, CAT, HSPA5, DICER1
15	muscle phenotype	MP:0005369	7.6	CALR, HSPG2, GNAS, ICAM1, IFNG, IGF1
16	nervous system phenotype	MP:0003631	7.4	HLA-C, PRL, CXCL10, SLC26A4, CP, NKX2-1
17	vision/eye phenotype	MP:0005391	7.2	TTR, ACVR2A, PTEN, TNFRSF9, HSPG2, ICAM1
18	behavior/neurological phenotype	MP:0005386	6.7	ACVR1, PLA2G6, SST, PTEN, HLA-C, ESR2
19	normal phenotype	MP:0002873	6.6	HSPA5, GNAS, ALPP, ALB, IFNG, IGF1
20	cardiovascular system phenotype	MP:0005385	4.9	ACVR2B, HGF, ADORA2A, ACVR2A, ACVR1, G6PD
21	homeostasis/metabolism phenotype	MP:0005376	2.5	TFCP2L1, TDG, PRL, CXCL10, SOD1, SLPI
22	respiratory system phenotype	MP:0005388	INF	PGF, THRB, ACVR1B, ACVR2A, ACVR2B, DICER1
23	cellular phenotype	MP:0005384	INF	TGFB3, TDG, CXCL10, SOD1, SLPI, CP
24	mortality/aging	MP:0010768	INF	VEGFC, PAX8, LGALS3, LEP, S100A4, XBP1
25	growth/size phenotype	MP:0005378	INF	RET, SELE, BRAF, CALR, , HRAS
26	digestive/alimentary phenotype	MP:0005381	INF	SLC5A8, NKX2-1, , ESR2, TNFRSF4, PTEN
27	craniofacial phenotype	MP:0005382	INF	DICER1, ACVR2A, ACVR1B, ACVR1, THRB, TDG

Articles related to goiter:

(show top 50)    (show all 175)

id	Title	Authors	Year	Affiliating Genes
1	Increased lipid peroxidation and impaired enzymatic a ntioxidant defense mechanism in thyroid tissue with multinodular goiter and pap illary carcinoma. (20171198)	Erdamar H.... Demirci H.	2010	SOD1
2	Bone mineral density and metabolism in levothyroxine- treated adolescent girls with euthyroid diffuse goiter. (20205099)	Matusik P.... Januszek-Trzciakowska A.	2010	BGLAP
3	Genetics and phenomics of hypothyroidism and goiter d ue to thyroglobulin mutations. (20093166)	Targovnik H.M.... Rivolta C.M.	2010	TG
4	A germline mutation (A339V) in thyroid transcription factor-1 (TITF-1/NKX2.1) in patients with multinodular goiter and papillary thyroid carcinoma. (19176457)	Ngan E.S.... Garcia-BarcelA^ M.M.	2009	NKX2-1
5	Pten loss in the mouse thyroid causes goiter and follicular adenomas: insights into thyroid function and Cowden disease pathogenesis. (17283127)	Yeager N.... Di Cristofano A.	2007	PTEN
6	Iodine-131 given for therapeutic purposes modulates differently interferon-gamma-inducible alpha-chemokine CXCL10 serum levels in patients with active Graves' disease or toxic nodular goiter. (17244787)	Antonelli A.... Ferrannini E.	2007	CXCL10
7	Vitamin A supplementation in iodine-deficient African children decreases thyrotropin stimulation of the thyroid and reduces the goiter rate. (17921382)	Zimmermann M.B.... Mbhenyane X.	2007	RBP4, TG
8	Peripheral blood levels of thyroglobulin mRNA and serum thyroglobulin concentrations after radioiodine ablation of multinodular goiter with or without pre-treatment with recombinant human thyrotropin. (17848834)	Rubio I.G.... Medeiros-Neto G.	2007	TG
9	Histopathological and molecular studies in patients with goiter and hypercalcitoninemia: reactive or neoplastic C-cell hyperplasia? (17639053)	Verga U.... Fugazzola L.	2007	CALCA
10	Three mutations (p.Q36H, p.G418fsX482, and g.IVS19-2A-->C) in the dual oxidase 2 gene responsible for congenital goiter and iodide organification defect. (16322276)	Varela V.... Targovnik H.M.	2006	DUOX2
11	A multinodular goiter as the initial presentation of a renal cell carcinoma harbouring a novel VHL mutation. (17067398)	Bugalho M.J.... Sobrinho L.G.	2006	VHL, NKX2-1
12	Autoimmunization and multinodular large toxic goiter therapy using repeated doses of 131I (17263226)	Pisarek M.... Sowinski J.	2006	ATP5O
13	Complete inhibition of goiter in mice requires combined gene therapy modification of angiopoietin, vascular endothelial growth factor, and fibroblast growth factor signaling. (15817662)	Ramsden J.D.... Eggo M.C.	2005	FLT1, FGFR1, TEK
14	A pregnant woman with autoimmune thyroiditis and recurrent goiter (15326651)	Santoe M.F.... Berghout A.	2004	TPO
15	Correlation between serum thyroglobulin and thyroid stimulating hormone in populations with non-toxic goiter (12899791)	Hu F.N.... Tao C.M.	2003	TPO, TG
16	Five novel inactivating mutations in the thyroid peroxidase gene responsible for congenital goiter and iodide organification defect. (12938097)	Rivolta C.M.... Targovnik H.M.	2003	TPO
17	Screening the SLC26A4 gene in probands with deafness and goiter (Pendred syndrome) ascertained from a large group of students of the schools for the deaf in Turkey. (12974744)	Tekin M.... Akar N.	2003	SLC26A4
18	Cytologic characterization of postiodization residual goiter in schoolchildren by fine needle biopsy. (12685194)	Karak A.K.... Verma K.	2003	TG
19	Lack of reported mutations in a Japanese case of toxic multinodular goiter. (12232474)	Hanamitsu M.... Kitano H.	2002	TSHR
20	Insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels of children living in an iodine- and selenium-d eficient endemic goiter area. (12666822)	Aydin K.... Kurtoglu S.	2002	IGFBP3
21	Diagnostic utility of cytokeratin 19 expression in multinodular goiter with papillary areas and papillary carcinoma of thyroid. (12446919)	Erkilic S.... Kocer N.E.	2002	KRT19
22	Thyroid status and leptin in Basedow-Graves and multinodular goiter patients. (11549117)	Seven R.	2001	LEP
23	A new locus for a dominant form of multinodular goiter on 3q26.1-q26.3. (11396950)	Takahashi T.... Koizumi A.	2001	TPO, MNG3
24	Erythrocyte, plasma, and serum antioxidant activities in untreated toxic multinodular goiter patients. (11295364)	AlicigA1zel Y.... Smith M.A.	2001	CP
25	Aggressive metastatic follicular thyroid carcinoma with anaplastic transformation arising from a long-standing goiter in a patient with Pendred's syndrome. (11716048)	Camargo R.... Medeiros-Neto G.	2001	SLC26A4
26	Effects of propylthiouracil treatment on antioxidant activities in blood of toxic multinodular goiter patients. (10895078)	Ozdem S.... KarayalAsin U.	2000	SOD1, GSR, CAT
27	The role of selenium in iodine metabolism in children with goiter. (10620526)	Zagrodzki P.... Zachwieja Z.	2000	GPX3
28	The evaluation of goiter frequency and iodine prophy laxis efficiency in children population in Wielkopolska area from 1992 to 1998 (12818081)	Baczyk M.... Korman E.	2000	TG
29	Activin A and activin receptors in the human thyroid: a link to the female predominance of goiter? (11069203)	Schulte K.M.... Roher H.D.	2000	ACVR2B, ACVR1, ACVR1B
30	Screening of thyrotropin receptor mutations by fine-needle aspiration biopsy in autonomous functioning thyroid nodules in multinodular goiters. (10319940)	Tassi V.... De Filippis V.	1999	TSHR
31	Linkage of familial euthyroid goiter to the multinodular goiter-1 locus and exclusion of the candidate genes thyroglobulin, thyroperoxidase, and Na+/I- symporter. (10523025)	Neumann S.... Paschke R.	1999	TPO, TG
32	Two novel cysteine substitutions (C1263R and C1995S) of thyroglobulin cause a defect in intracellular transport of thyroglobulin in patients with congenital goiter and the variant type of adenomatous goiter. (10199792)	Hishinuma A.... Ieiri T.	1999	TG
33	Evidence for the segregation of three different mutated alleles of the thyroglobulin gene in a Brazilian family with congenital goiter and hypothyroidism. (9588493)	Targovnik H.M.... Medeiros-Neto G.	1998	TG
34	Identification of constitutively activating somatic thyrotropin receptor mutations in a subset of toxic multinodular goiters. (9398745)	Holzapfel H.P.... Paschke R.	1997	TSHR
35	Fairly elevated incidence of goiter with marginally low urinary iodine in adolescents living in the north-western part of Tunisia. (9258540)	El May M.V.... Mtimet S.	1997	TG
36	Octreotide and bromocriptine suppress thyroid hormone levels and thyroid nodule in an acromegalic patient with nontoxic autonomous goiter. (9228467)	Sakane N.... Kondo M.	1997	IGF1, PRL, GH1
37	Optimal laboratory testing for diagnosis and monitori ng of thyroid nodules, goiter, and thyroid cancer. (8565224)	Ladenson P.W.	1996	TG
38	Thyroglobulin exon 10 gene point mutation in a patient with endemic goiter. (8936666)	PAcrez-Centeno C.... Miralles-GarcA-a J.M.	1996	TG
39	Failure to detect thyroid growth-promoting activity in immunoglobulin G of patients with endemic goiter. (7909816)	Vitti P.... Pinchera A.	1994	TPO, TG
40	Dissociation of thyrotropin-dependent enzyme activities, reduced iodide transport, and preserved iodide organification in nonfunctioning thyroid adenoma and multinodular goiter. (8027249)	Masini-Repiso A.M.... Coleoni A.H.	1994	TPO
41	Thyroid status in anemic pregnant women under conditions of endemic goiter (7899433)	Zel'tser M.E.... Nugmanova M.I.	1994	SERPINA7
42	Immunohistochemical studies on thyroid peroxidase and thyroglobulin in 13 human thyroid tumors and 7 Graves' goiters. (7951537)	Watanabe K.... Hosoya T.	1993	TPO, TG
43	A nonsense mutation causes human hereditary congenital goiter with preferential production of a 171-nucleotide-deleted thyroglobulin ribonucleic acid messenger. (8325944)	Targovnik H.M.... Vassart G.	1993	TG
44	Serum thyroglobulin level in patients with diffuse and nodular goiter, after therapeutic application of stable iodine. (1628693)	Djurica S.N.... Tasovac-Ponomarev D.	1992	TG
45	Osteocalcin in diffuse toxic goiter (1377070)	Balabolkin M.I.... Mkrtumian A.M.	1992	BGLAP
46	Identification of a 3' splice site mutation in the thyroglobulin gene in a case of congenital familial goiter (1397384)	Ieiri T.... Shimoda S.	1992	TG
47	A 3' splice site mutation in the thyroglobulin gene responsible for congenital goiter with hypothyroidism. (1752952)	Ieiri T.... Vassart G.	1991	TG
48	Differential levels of thyroid peroxidase and thyroglobulin messenger ribonucleic acids in congenital goiter with defective thyroglobulin synthesis. (2096156)	Targovnik H.M.... Pisarev M.A.	1990	TPO, TG
49	Lack of response of peripheral blood mononuclear cells to thyroid microsomal antigen in nontoxic nodular goiters. (2121217)	Sakatsume Y.... VolpAc R.	1990	TPO, IFNG
50	Functional state of the stomach in patients with diffuse toxic goiter and hypothyroidism (1173954)	Mukhamadieva G.A.	1975	TFCP2L1

Genes related to goiter according to GeneCards:

(show top 50)    (show all 123)

id	Symbol	Description	Score	GeneCards Section Context
1	TG	thyroglobulin	11.1	Publications, Summaries
2	TPO	thyroid peroxidase	11.1	Publications, Summaries
3	MNG2	multinodular goiter 2	11.1	Aliases & Descriptions, Publications
4	MNG3	Multinodular goiter-3	11.1	Aliases & Descriptions, Publications
5	THRB	thyroid hormone receptor, beta	11.1	Summaries
6	TSHR	thyroid stimulating hormone receptor	11.0	Publications
7	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
8	TRH	thyrotropin-releasing hormone	11.0	Publications
9	GNAS	GNAS complex locus	11.0	Publications
10	SLC26A4	solute carrier family 26, member 4	11.0	Publications
11	NKX2-1	NK2 homeobox 1	11.0	Publications
12	MNG1	multinodular goitre 1	11.0	Publications
13	IL6R	interleukin 6 receptor	11.0	Publications
14	LGALS3	lectin, galactoside-binding, soluble, 3	11.0
15	KRT19	keratin 19	11.0	Publications
16	ADCY10	adenylate cyclase 10 (soluble)	11.0
17	ICAM1	intercellular adhesion molecule 1	11.0	Publications
18	BGLAP	bone gamma-carboxyglutamate (gla) protein	11.0	Publications
19	STT3A	STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae)	11.0
20	SERPINA7	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7	11.0	Publications
21	GSR	glutathione reductase	11.0	Publications
22	FASLG	Fas ligand (TNF superfamily, member 6)	11.0
23	HRAS	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	11.0	Publications
24	SHBG	sex hormone-binding globulin	11.0	Publications
25	BRAF	v-raf murine sarcoma viral oncogene homolog B1	11.0
26	HSPG2	heparan sulfate proteoglycan 2	11.0
27	RET	ret proto-oncogene	11.0
28	CAT	catalase	11.0	Publications
29	IFNG	interferon, gamma	11.0	Publications
30	NAALADL1	N-acetylated alpha-linked acidic dipeptidase-like 1	11.0
31	LYPD1	LY6/PLAUR domain containing 1	11.0
32	TMSB10	thymosin beta 10	11.0
33	TDG	thymine-DNA glycosylase	11.0
34	SLC5A5	solute carrier family 5 (sodium iodide symporter), member 5	11.0	Publications
35	PIGF	phosphatidylinositol glycan anchor biosynthesis, class F	11.0	Publications
36	TNFRSF4	tumor necrosis factor receptor superfamily, member 4	11.0
37	INHBA	inhibin, beta A	11.0	Publications
38	INSL3	insulin-like 3 (Leydig cell)	11.0
39	DIO2	deiodinase, iodothyronine, type II	11.0
40	DICER1	dicer 1, ribonuclease type III	11.0	Publications
41	TGFB3	transforming growth factor, beta 3	11.0	Publications
42	TNFRSF9	tumor necrosis factor receptor superfamily, member 9	11.0
43	PAX8	paired box 8	11.0
44	LPO	lactoperoxidase	11.0
45	LMOD1	leiomodin 1 (smooth muscle)	11.0
46	VHL	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	11.0	Publications
47	TXNRD2	thioredoxin reductase 2	11.0
48	ADORA2A	adenosine A2a receptor	11.0
49	CP	ceruloplasmin (ferroxidase)	11.0	Publications
50	S100A4	S100 calcium binding protein A4	11.0

Pathways related to goiter according to GeneDecks:

(show top 50)    (show all 113)

id	Pathway	Score	Top Affiliating Genes
1	Renal cell carcinoma20	10.5	PGF, HGF, VHL, TGFB3, HRAS, MET
2	Graft-versus-host disease20	10.1	CD80, IL1A, CD28, CD86, HLA-C, FASLG
3	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.7	BGLAP, CALR, CALCA, CGA, FASLG, THRB
4	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.7	PTH, CALCA, THRB, FASLG, IL1A, BGLAP
5	Rheumatoid arthritis20	9.7	VEGFA, CD28, CD86, CD80, FLT1, IL1A
6	Ras Pathway36	9.7	VEGFC, FGF7, FGFR1, MET, HRAS, TEK
7	Allograft rejection20	9.6	IL2, IFNG, FAS, FASLG, CD86, HLA-C
8	Pathways in cancer20	9.4	VEGFC, HGF, TGFB3, FAS, MET, FGFR1
9	Endothelin-1 Signaling Pathway36	9.4	IL2, BRAF, IL1A, IL1B, ANGPT1, CXCL10
10	Autoimmune thyroid disease20	9.4	TSHR, CTLA4, TPO, HLA-C, FAS, FASLG
11	STAT3 Pathway36	9.3	ACVR1, ACVR2B, TEK, TNFRSF9, TNFRSF4, HRAS
12	IL-6 Pathway36	9.3	HGF, CXCL10, TGFB3, ANGPT1, HRAS, ANGPT2
13	14-3-3 Induced Intracellular Signaling36	9.2	PGF, TGFB3, TGFB2, TEK, GH1, FLT1
14	Type I diabetes mellitus20	9.0	IL1B, FASLG, FAS, HLA-C, CD28, CD86
15	ERK Signaling36	9.0	TEK, FLT1, ESR2, CD80, VEGFC, BRAF
16	eNOS Signaling36	9.0	FGFR1, MET, FGF7, IL2, ESR2, GH1
17	PEDF Induced Signaling36	9.0	IL1B, IL1A, BRAF, CD80, IL2, ANGPT2
18	JNK Pathway36	9.0	FGF7, FLT1, CD80, IL2, IL6R, ANGPT2
19	ERK5 Signaling36	9.0	MET, GH1, IL2, VEGFC, FLT1, FGFR1
20	Akt Signaling36	8.9	FGFR1, MET, IL2, IL6R, TNFRSF9, ACVR1
21	Paxillin Interactions36	8.9	TGFB3, GH1, TEK, TGFB2, VEGFC, IGF1
22	PTEN Pathway36	8.6	FGFR1, FGF7, FLT1, VEGFC, BRAF, PGF
23	Rac1 Pathway36	8.6	GH1, TGFB2, HRAS, TGFB3, FGF7, PGF
24	Molecular Mechanisms of Cancer36	8.6	HRAS, ANGPT1, ANGPT2, IL6R, IL2, MET
25	Nanog in Mammalian ESC Pluripotency36	8.5	TEK, FLT1, TGFB2, HGF, PGF, GH1
26	Apoptotic Pathways in Synovial Fibroblasts36	8.4	VEGFC, HGF, PGF, TGFB3, GH1, IGF1
27	DHA Signaling36	8.4	IL1B, IL2, IGF1, GH1, PLA2G6, TGFB2
28	PPAR Pathway36	8.4	TGFB2, IL2, FGFR1, VEGFC, FGF7, MET
29	NF-KappaB (p50-p65) Pathway36	8.4	VEGFC, FLT1, FGF7, FGFR1, MET, IL1A
30	Estrogen Pathway36	8.4	GH1, TEK, TGFB2, HGF, PGF, ESR2
31	Telomerase Components in Cell Signaling36	8.3	FLT1, FGF7, MET, IGF1, GH1, TGFB3
32	NFAT in Immune Response36	8.3	FGFR1, FGF7, FLT1, CD80, CD86, CD28
33	NF-KappaB Family Pathway36	8.3	GH1, MET, IL1A, IL1B, IL2, HGF
34	eIF2 Pathway36	8.3	VEGFC, IGF1, IL2, PGF, TGFB3, HGF
35	GPCR Pathway36	8.2	FGFR1, IL2, IGF1, PGF, HRAS, GH1
36	MAPK Signaling36	8.2	IL1A, IL1B, IL2, IGF1, BRAF, MET
37	Pancreatic Adenocarcinoma36	8.2	IL2, MET, FGFR1, IGF1, FLT1, FGF7
38	p53 Mediated Apoptosis36	8.1	IL2, IGF1, GH1, PTEN, TGFB2, TGFB3
39	IP3 Pathway36	8.1	FGF7, VEGFC, FLT1, FGFR1, MET, IL2
40	Mitochondrial Apoptosis36	8.0	HGF, FLT1, FGFR1, FGF7, MET, VEGFC
41	TGF-Beta Pathway36	8.0	TGFB2, TGFB3, PGF, HGF, GH1, HRAS
42	Tec Kinases Signaling36	8.0	VEGFC, FGFR1, MET, IL1A, IL1B, IL2
43	MAPK Family Pathway36	8.0	IGF1, HRAS, TGFB2, PGF, HGF, GH1
44	PAK Pathway36	7.9	IL1A, ANGPT1, IL1B, MET, FGFR1, FGF7
45	Cytokine-cytokine receptor interaction20	7.9	IFNG, GH1, TPO, TNFRSF4, TNFRSF9, ACVR2B
46	Rho Family GTPases36	7.9	FGFR1, GH1, HGF, PGF, CXCL10, FGF7
47	p70S6K Signaling36	7.7	FLT1, TGFB2, HBG2, GH1, HRAS, IGF1
48	JAK-STAT Pathway36	7.7	FGF7, FGFR1, FLT1, CD80, VEGFC, MET
49	p38 Signaling36	7.6	TNFRSF4, GH1, HRAS, IGF1, ANGPT1, ANGPT2
50	Antioxidant Action of Vitamin-C36	7.5	VEGFC, CD28, CD80, HRAS, GH1, TXNRD2

Compounds related to goiter according to GeneDecks:

(show top 50)    (show all 423)

id	Compound	Score	Top Affiliating Genes
1	iodide32 18	11.5	SERPINA7, BRAF, LPO, LMOD1, PAX8, IYD
2	ly29400232	10.3	RET, SELE, VHL, VEGFA, LEP, IL1B
3	iodine32 18	10.9	SERPINA7, BRAF, LMOD1, MET, GNAS, TRH
4	25-hydroxyvitamin d32	9.8	BGLAP, LEP, IGFBP5, ALPP, PTH, SLPI
5	aspartate32	9.8	RET, RBP4, SERPINA7, BRAF, CGA, GSR
6	h2o232	9.4	SELL, LPO, BGLAP, LGALS3, LEP, CGA
7	methimazole32 9 9	11.4	SELE, SELL, SERPINA7, LPO, BGLAP, GSR
8	deoxypyridinoline32	9.0	BGLAP, IL6R, IGFBP3, IGF1, ALPP, GH1
9	prostacyclin32	9.0	SELE, VEGFA, LEP, CGA, FLT1, IL1A
10	gnrh32	9.0	SELL, LEP, INS, FGFR1, FASLG, IGFBP3
11	epinephrine32 9 18 9	11.7	SELE, SELL, LPO, LEP, CGA, INS
12	progesterone32 42 9 18 9	12.7	RBP4, SERPINA7, BRAF, VEGFC, CGA, FLT1
13	glutamate32	8.7	BRAF, LGALS3, LEP, P4HB, INS, GSR
14	superoxide32 18	9.7	SELL, LPO, LGALS3, P4HB, FLT1, GSR
15	ascorbic acid32 18	9.6	RBP4, LPO, BGLAP, P4HB, CGA, IL1A
16	rapamycin32 42	9.5	SELL, BRAF, VHL, VEGFA, CD86, CD80
17	triiodothyronine32	8.5	RBP4, SERPINA7, LMOD1, LEP, CGA, GPX3
18	vitamin a32 9 18 9	11.4	RET, RBP4, SERPINA7, LEP, P4HB, CGA
19	acth32	8.4	SERPINA7, LGALS3, LEP, INS, IL1A, IL1B
20	oligonucleotide32	8.4	RET, BRAF, VHL, VEGFC, PAX8, LGALS3
21	cyclosporin a32 42	9.4	BGLAP, LEP, CIITA, CGA, CD28, CD86
22	phosphatidylinositol32	8.2	RET, BRAF, VHL, VEGFC, LGALS3, LEP
23	octreotide32 42 9 9	11.2	VEGFA, INS, IGFBP3, IGF1, GNAS, CALCA
24	pd 98,05932	7.8	RET, BRAF, VEGFC, LEP, FGF7, FGFR1
25	cysteine32	7.8	RBP4, LPO, LMOD1, BGLAP, LGALS3, P4HB
26	norepinephrine32 9 18 9	10.7	SELE, SELL, LPO, LEP, CGA, INS
27	indomethacin32 9 9	9.7	SELL, LEP, CGA, GSR, IL1A, IL1B
28	heparin32 9 18 9	10.6	VEGFC, BGLAP, LGALS3, CGA, FLT1, FGF7
29	calcitriol32 42 9 18 9	11.5	BGLAP, IL1A, IL1B, IL2, IGFBP5, IGFBP3
30	oxygen32 18	8.5	PIGF, RBP4, LPO, LGALS3, CIITA, P4HB
31	steroid32	7.4	RBP4, SERPINA7, LEP, CIITA, S100A4, CGA
32	arginine32	7.2	RET, SERPINA7, BRAF, LPO, BGLAP, LEP
33	testosterone32 9 18 9	10.0	RET, SELE, SERPINA7, VEGFC, BGLAP, CGA
34	tamoxifen32 34 9 9	9.7	SELE, SERPINA7, VEGFA, BGLAP, LEP, CGA
35	hydrocortisone32 9 9	8.7	BGLAP, FLT1, INS, FGF7, IL1A, IL1B
36	creatinine32	6.7	RBP4, SELE, SELL, SERPINA7, LEP, P4HB
37	vegf32	6.5	PIGF, RET, SELE, BRAF, VHL, VEGFC
38	calcium32 9 18 9	9.5	RBP4, BRAF, VHL, VEGFC, LPO, BGLAP
39	ribonucleic acid32	6.4	RET, RBP4, SERPINA7, VEGFC, PAX8, CIITA
40	thymidine32 18	7.3	VEGFC, CIITA, P4HB, FLT1, FGF7, FGFR1
41	cycloheximide32	6.3	SELE, SELL, VEGFA, LEP, CIITA, P4HB
42	cholesterol32 9 18 9	9.3	RBP4, SELE, SERPINA7, LEP, CIITA, P4HB
43	vitamin d32	6.3	BGLAP, LGALS3, XBP1, CGA, FGF7, MET
44	alanine32	6.2	RET, RBP4, SELE, SELL, SERPINA7, BRAF
45	estrogen32	6.2	RBP4, SERPINA7, VHL, VEGFC, LMOD1, BGLAP
46	thyroxine32 18	7.1	RBP4, SERPINA7, LPO, LMOD1, BGLAP, PAX8
47	lactate32	5.7	RBP4, SELE, SELL, LPO, LGALS3, P4HB
48	dexamethasone32 42 34 9 9	9.1	RBP4, SELL, VEGFA, VEGFC, LMOD1, BGLAP
49	serine32	INF	RET, RBP4, SELE, SELL, SERPINA7, BRAF
50	tyrosine32	INF	PIGF, RET, SELL, SERPINA7, BRAF, VHL

Cellular components related to goiter according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	neuronal cell body	GO:043025	10.0	ADCY10, SOD1, TGFB3, TGFB2, SST, CALCA
2	external side of plasma membrane	GO:009897	9.8	CXCL10, CTLA4, TNFRSF9, TNFRSF4, CALR, ICAM1
3	apical plasma membrane	GO:016324	9.7	SLC5A8, SLC26A4, DPP4, TEK, DUOX2, IL6R
4	insulin-like growth factor binding protein complex	GO:016942	9.7	IGF1, IGFBP3, IGFBP5
5	cell surface	GO:009986	9.4	ACVR2B, ACVR2A, ACVR1B, TGFB2, TGFB3, DPP4
6	integral to plasma membrane	GO:005887	9.0	TNFRSF9, TEK, CTLA4, ACVR2B, ACVR2A, ACVR1B
7	platelet alpha granule lumen	GO:031093	9.0	HGF, TGFB3, TGFB2, ALB, IGF1, VEGFC
8	extracellular space	GO:005615	5.1	LEP, FLT1, INS, FGF7, MET, IL1A
9	extracellular region	GO:005576	3.9	SOD1, SLPI, CP, PGF, HGF, CXCL10
10	plasma membrane	GO:005886	INF	ACVR2B, CTLA4, DIO2, PTEN, TEK, TPO

Biological processes related to goiter according to GeneDecks:

(show top 50)    (show all 66)

id	Name	GO ID	Score	Top Affiliating Genes
1	hormone biosynthetic process	GO:042446	10.8	TPO, DUOX2, DIO2, TG
2	hydrogen peroxide catabolic process	GO:042744	10.6	DUOX2, TPO, CAT, GPX3, LPO
3	positive regulation of interleukin-2 biosynthetic process	GO:045086	10.6	IL1B, IL1A, CD80, CD86, CD28
4	positive regulation of follicle-stimulating hormone secretion	GO:046881	10.6	ACVR2A, INHBB, INHBA, LEP
5	thyroid gland development	GO:030878	10.5	NKX2-1, TGFB2, TG, DUOX2, CGA, PAX8
6	response to vitamin D	GO:033280	10.5	CXCL10, TGFB2, IL1B, BGLAP
7	thyroid hormone generation	GO:006590	10.4	SLC5A5, DIO2, DUOX2, TPO, IYD, CGA
8	positive regulation of pathway-restricted SMAD protein phosphorylation	GO:010862	10.4	TGFB3, ACVR1, ACVR1B, ACVR2A, INHBA
9	Tie receptor signaling pathway	GO:048014	10.4	TEK, ANGPT1, ANGPT2
10	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	GO:060665	10.3	HGF, MET, FGFR1, FGF7
11	protein secretion	GO:009306	10.3	CXCL10, PDIA4, ERP29, GNAS
12	glomerulus vasculature development	GO:072012	10.3	TEK, ANGPT1, ANGPT2
13	positive regulation of cell division	GO:051781	10.3	PGF, TGFB3, TGFB2, CAT, IL1B, IL1A
14	response to ethanol	GO:045471	10.3	NKX2-1, SOD1, TRH, ICAM1, BGLAP, RBP4
15	ovarian follicle development	GO:001541	10.3	SOD1, ESR2, ICAM1, ANGPT1, FGF7, INHBB
16	positive regulation of peptidyl-serine phosphorylation	GO:033138	10.2	TEK, ANGPT1, MET, VEGFA, BRAF
17	positive regulation of bone mineralization	GO:030501	10.2	TGFB3, ACVR1, ACVR2A, ACVR2B, PTH
18	positive regulation of receptor internalization	GO:002092	10.2	SELE, VEGFA, ANGPT1, GH1
19	leukocyte migration	GO:050900	10.2	TEK, HRAS, ICAM1, ANGPT1, ANGPT2, ATP1B1
20	myoblast proliferation	GO:051450	10.1	HGF, IGF1, MET
21	positive regulation of activin receptor signaling pathway	GO:032927	10.1	ACVR2B, ACVR2A, ACVR1B
22	response to lipopolysaccharide	GO:032496	10.1	NKX2-1, CXCL10, DIO2, FAS, FASLG, IL1A
23	positive regulation of apoptotic process	GO:043065	10.1	ADCY10, SOD1, TGFB2, CTLA4, ESR2, IGFBP3
24	inner ear development	GO:048839	10.1	TGFB3, TGFB2, DUOX2, IGF1, MAF
25	response to estrogen stimulus	GO:043627	10.0	TGFB3, TSHB, KRT19, ANGPT1, FAS, BGLAP
26	cell surface receptor signaling pathway	GO:007166	10.0	CXCL10, PRL, SST, HRAS, IFNG, MET
27	positive regulation of insulin-like growth factor receptor signaling pathway	GO:043568	9.9	IGFBP5, IGFBP3, IGF1, GH1
28	positive regulation of angiogenesis	GO:045766	9.9	TEK, ANGPT2, IL1B, IL1A, FLT1, VEGFA
29	negative regulation of transcription from RNA polymerase II promoter	GO:000122	9.8	NKX2-1, TDG, TFCP2L1, THRB, DICER1, PTH
30	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.8	TEK, HRAS, ANGPT1, IL1B, IL1A, BRAF
31	female pregnancy	GO:007565	9.8	PGF, PRL, TFCP2L1, TGFB3, TGFB2, GNAS
32	angiogenesis	GO:001525	9.7	PGF, TGFB2, DICER1, PTEN, TEK, HSPG2
33	positive regulation of mitosis	GO:045840	9.6	IGF1, IL1B, IL1A, MET, INS, CD28
34	positive regulation of DNA replication	GO:045740	9.5	TGFB3, HRAS, CALR, IGF1, MET, INS
35	response to drug	GO:042493	9.5	CALR, SST, TGFB2, SOD1, PGF, ADORA2A
36	induction of apoptosis	GO:006917	9.4	TGFB3, TGFB2, ACVR1B, PTEN, TNFRSF9, FAS
37	negative regulation of cell proliferation	GO:008285	9.4	PTEN, SST, TGFB2, TGFB3, ADORA2A, TNFRSF9
38	platelet degranulation	GO:002576	9.3	HGF, SOD1, TGFB3, TGFB2, HSPA5, ALB
39	platelet activation	GO:030168	9.1	HGF, SOD1, TGFB3, TGFB2, HSPA5, ALB
40	response to hypoxia	GO:001666	9.1	CAT, TRH, TGFB2, TGFB3, DPP4, PGF
41	positive regulation of MAPK cascade	GO:043410	9.1	HRAS, IGF1, IGFBP3, IL6R, FGFR1, INS
42	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.0	HGF, GH1, IGF1, ANGPT1, IL6R, FGF7
43	anti-apoptosis	GO:006916	8.9	IGF1, HSPA5, TEK, SOD1, HGF, ANGPT1
44	signal transduction	GO:007165	8.6	HRAS, ESR2, TRH, TEK, ACVR2B, ACVR1B
45	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	8.6	HGF, TGFB2, TEK, GH1, CAT, IGF1
46	cell-cell signaling	GO:007267	8.4	ADORA2A, FASLG, IL2, IL1B, INSL3, INS
47	blood coagulation	GO:007596	8.4	HRAS, TEK, HBG2, TGFB2, TGFB3, SOD1
48	negative regulation of apoptotic process	GO:043066	8.1	CAT, TEK, PTEN, DICER1, ACVR1, TGFB2
49	positive regulation of cell proliferation	GO:008284	7.3	PGF, FGFR1, FGF7, INS, FLT1, CD86
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	, HRAS, PTH, DICER1, ACVR1B, ACVR1

Molecular functions related to goiter according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	coreceptor activity	GO:015026	10.2	CD28, CD86, CD80, ACVR2A
2	receptor signaling protein serine/threonine kinase activity	GO:004702	10.2	TGFB2, ACVR1, ACVR1B, ACVR2A, ACVR2B
3	activin binding	GO:048185	10.1	ACVR1, ACVR1B, ACVR2A, ACVR2B
4	transmembrane receptor protein serine/threonine kinase activity	GO:004675	10.1	ACVR2A, ACVR1B, ACVR1
5	protein heterodimerization activity	GO:046982	10.0	HGF, ADORA2A, PGF, TGFB3, TGFB2, MAF
6	cytokine activity	GO:005125	9.8	TGFB2, IFNG, FASLG, IL2, IL1B, IL1A
7	protease binding	GO:002020	9.6	DPP4, INSL3, INS, CD28, SELL
8	protein homodimerization activity	GO:042803	9.6	ACVR1, G6PD, TKT, TGFB2, DPP4, SOD1
9	growth factor binding	GO:019838	9.5	FLT1, ACVR2B, ACVR2A, ACVR1B
10	chaperone binding	GO:051087	9.4	CP, SOD1, CALR, HSPA5, ALB
11	growth factor activity	GO:008083	8.7	IGF1, GH1, TGFB2, TGFB3, PGF, HGF
12	hormone activity	GO:005179	7.9	LEP, PRL, TG, TSHB, TTR, SST
13	protein binding	GO:005515	INF	TXNRD2, TEK, PTEN, DICER1, CTLA4, PDIA4