MCID: GND003
MIFTS: 39

Gonadal Disease malady

Categories: Endocrine diseases

Aliases & Classifications for Gonadal Disease

Aliases & Descriptions for Gonadal Disease:

Name: Gonadal Disease 12 14
Gonadal Disorders 42 69
Gonadal Dysfunction 52

Classifications:



External Ids:

Disease Ontology 12 DOID:2277
MeSH 42 D006058
NCIt 47 C26786
UMLS 69 C0018050

Summaries for Gonadal Disease

Disease Ontology : 12 An endocrine system disease that is located in the gonads.

MalaCards based summary : Gonadal Disease, also known as gonadal disorders, is related to hypogonadism and vaginal adenoma. An important gene associated with Gonadal Disease is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Peptide ligand-binding receptors and Peptide hormone metabolism. The drugs Methyltestosterone and Testosterone have been mentioned in the context of this disorder. Affiliated tissues include the gonads, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Related Diseases for Gonadal Disease

Diseases related to Gonadal Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
id Related Disease Score Top Affiliating Genes
1 hypogonadism 10.6
2 vaginal adenoma 10.3 IGF1 POMC
3 8p23.1 duplication syndrome 10.3 FSHR NR5A1 SRY
4 caudal regression syndrome 10.3 GH1 IGF1 POMC
5 benign peritoneal mesothelioma 10.3 GNRH1 NR5A1 POMC
6 femur bifid with monodactylous ectrodactyly 10.3 CRH IGF1 POMC
7 malignant otitis externa 10.3 CRH NR5A1 POMC
8 traumatic glaucoma 10.3 CRH IGF1 POMC
9 rheumatic encephalitis 10.3 GH1 IGF1 POMC
10 infections, recurrent, with encephalopathy, hepatic dysfunction, and cardiovasuclar malformations 10.3 CRH GH1 POMC
11 immune system organ benign neoplasm 10.3 CRH IGF1 POMC
12 adult i blood group with or without congenital cataract 10.3 CRH GH1 POMC
13 intramuscular hemangioma 10.3 AMH GNRH1 SRY
14 autoimmune disease of endocrine system 10.3 AR CRH POMC
15 cold-induced sweating syndrome 2 10.3 GH1 IGF1 POMC
16 intermittent squint 10.2 CRH GH1 GNRH1 POMC
17 spinocerebellar ataxia 25 10.2 AMH FSHR GNRH1
18 african histoplasmosis 10.2 GNRH1 POMC
19 bile acid synthesis defect, congenital, 4 10.2 GH1 GNRH1 IGF1 POMC
20 cone dystrophy 10.2 AMH NR5A1 SRY
21 vertebral artery occlusion 10.2 GNRH1 INS POMC
22 intraventricular meningioma 10.2 AR SHBG SRY
23 deafness, autosomal recessive 51 10.2 AMH NR5A1 SRY
24 loeffler endocarditis 10.2 CRH NR5A1 POMC
25 ameloblastoma 10.2 NR5A1 POMC SULT2A1
26 astroblastoma 10.2 CRH GNRH1 POMC SHBG
27 hypogonadism cardiomyopathy 10.2 CRH GH1 POMC SHBG
28 congenital articular rigidity 10.2 AR SHBG SRY
29 retroperitoneal sarcoma 10.2 AMH GNRH1 SHBG
30 adams-oliver syndrome 6 10.2 GH1 GNRH1 INS
31 autism susceptibility, x-linked 2 10.2 SHOX SHOX2 SRY
32 endocrine organ benign neoplasm 10.2 CRH IGF1 POMC
33 stomach carcinoma in situ 10.2 IGF1 SHBG SULT2A1
34 farmer's lung 10.2 NR5A1 SHBG SRY
35 basal ganglia cerebrovascular disease 10.2 INS POMC SHBG
36 critical congenital heart disease 10.2 GH1 GNRH1 IGF1 KISS1R
37 merkel cell carcinoma 10.2 CRH INS POMC
38 primary effusion lymphoma 10.2 GH1 GNRH1 IGF1 KISS1R
39 childhood optic tract astrocytoma 10.2 CRH POMC SULT2A1
40 neurogenic arthropathy 10.2 IGF1 INS POMC
41 hypoglycemic coma 10.2 CRH GNRH1 INS
42 46 xx gonadal dysgenesis 10.2 AMH FSHR NR5A1 SRY
43 anisometropia 10.2 CRH GH1 POMC
44 lichen disease 10.2 CRH IGF1 POMC
45 antisynthetase syndrome 10.2 NR5A1 SRY
46 adult medulloblastoma 10.2 AR GNRH1 IGF1 SHBG
47 microtia, hearing impairment, and cleft palate 10.2 GH1 GHR IGF1
48 pulmonary neuroendocrine tumor 10.2 GH1 GHR POMC
49 capillary disease 10.2 AR POMC SHBG SRY
50 fatty liver disease 10.2 CRH INS POMC

Graphical network of the top 20 diseases related to Gonadal Disease:



Diseases related to Gonadal Disease

Symptoms & Phenotypes for Gonadal Disease

MGI Mouse Phenotypes related to Gonadal Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.21 AMH AR CRH FSHR GHR GNRH1
2 growth/size/body region MP:0005378 10.18 AR CRH FSHR GHR GNRH1 IGF1
3 homeostasis/metabolism MP:0005376 10.18 POMC PROKR2 SHOX2 AMH AR CRH
4 integument MP:0010771 10.02 AR CRH FSHR GHR GNRH1 IGF1
5 adipose tissue MP:0005375 10 AR CRH FSHR GHR IGF1 INS
6 nervous system MP:0003631 9.97 FSHR GHR GNRH1 IGF1 INS KISS1R
7 liver/biliary system MP:0005370 9.8 AR CRH GHR GNRH1 INS KISS1R
8 renal/urinary system MP:0005367 9.56 AR CRH GHR GNRH1 IGF1 INS
9 reproductive system MP:0005389 9.32 KISS1R NR5A1 PROKR2 AMH AR FSHR

Drugs & Therapeutics for Gonadal Disease

Drugs for Gonadal Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 746)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methyltestosterone Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-18-4 6010
2
Testosterone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 58-22-0 6013
3
Leuprolide Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 53714-56-0 3911 657181
4
Cyproterone Acetate Approved, Investigational Phase 4,Phase 2,Phase 3,Early Phase 1 427-51-0
5
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-28-2 5757 53477783
6
Ethinyl Estradiol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 57-63-6 5991
7
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 657-24-9 14219 4091
8
Drospirenone Approved Phase 4,Phase 3,Phase 2,Phase 1 67392-87-4 68873
9
Orlistat Approved, Investigational Phase 4,Phase 2 96829-58-2 3034010
10
Ganirelix Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 123246-29-7, 124904-93-4 25081094
11
Ezetimibe Approved Phase 4 163222-33-1 150311
12
Dihydrotachysterol Approved Phase 4,Phase 2,Phase 1 67-96-9 5281010 5311071
13
Progesterone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 57-83-0 5994
14
Zinc Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 7440-66-6 32051 23994
15
Letrozole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 112809-51-5 3902
16
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
17
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-23-7 5754 657311
18
Pioglitazone Approved, Investigational Phase 4,Early Phase 1 111025-46-8 4829
19
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 51-43-4 5816
20
Simvastatin Approved Phase 4,Phase 3 79902-63-9 54454
21
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
22
Cisplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
23
Benzocaine Approved Phase 4,Phase 3,Phase 2,Phase 1 1994-09-7, 94-09-7 2337
24
Everolimus Approved Phase 4,Phase 2,Phase 1 159351-69-6 6442177
25
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 1 22916-47-8 4189
26
Sirolimus Approved, Investigational Phase 4,Phase 2,Phase 1 53123-88-9 5284616 6436030 46835353
27
Triamcinolone Approved, Vet_approved Phase 4,Phase 3 124-94-7 31307
28
Lenograstim Approved Phase 4,Phase 2,Phase 3,Phase 1 135968-09-1
29
Bevacizumab Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 216974-75-3
30
Carboplatin Approved Phase 4,Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
31
Paclitaxel Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 33069-62-4 36314
32
Dutasteride Approved, Investigational Phase 4,Phase 2,Phase 1 164656-23-9 152945 6918296
33
Buserelin Approved Phase 4 57982-77-1
34
Menotropins Approved Phase 4,Phase 1,Phase 2 61489-71-2 5360545
35
Nafarelin Approved Phase 4 76932-56-4 16129618 25077649
36
Liraglutide Approved Phase 4 204656-20-2
37
Acetylcysteine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 616-91-1 12035
38
Aspirin Approved, Vet_approved Phase 4,Phase 2 50-78-2 2244
39
Rosiglitazone Approved, Investigational Phase 4 122320-73-4 77999
40
Alogliptin Approved Phase 4 850649-61-5 11450633
41
Hydroxocobalamin Approved Phase 4 13422-51-0 11953898 5460373 44475014
42
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
43
Citalopram Approved Phase 4 59729-33-8 2771
44 Moxonidine Approved Phase 4 75438-57-2 4810
45
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
46
Danazol Approved Phase 4 17230-88-5 28417
47
Tranexamic Acid Approved Phase 4 1197-18-8 5526
48
Norethindrone Approved Phase 4,Phase 2,Phase 3,Early Phase 1 68-22-4 6230
49
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
50
Sevoflurane Approved, Vet_approved Phase 4,Phase 2 28523-86-6 5206

Interventional clinical trials:

(show top 50) (show all 2645)
id Name Status NCT ID Phase
1 Efficacy and Safety of Pulsatile Gonadotropin Releasing Hormone Pump Treatment in Patients With Idiopathic Hypogonadotropic Hypogonadism Unknown status NCT02310074 Phase 4
2 Open-label, Follow-up Study of Oral Testosterone Undecanoate in Hypogonadal Men Unknown status NCT01699178 Phase 4
3 Comparative Validation of the Triptorelin Test for the Diagnosis of CPP in Girls Unknown status NCT01278290 Phase 4
4 Analysis of Genetic and Environmental Parameters Influencing Growth Rate of Precocious Puberty Children Unknown status NCT00438217 Phase 4
5 Comparison of Assisted Reproductive Technology (ART) Outcomes Between Two Protocols of Induction of Ovulation in Patients With Hypogonadotropic Hypogonadism Unknown status NCT02140515 Phase 4
6 Effect of Androgel on Type 2 Diabetic Males With Hypogonadism Unknown status NCT00350701 Phase 4
7 Co-administration of Low Dose hCG at the Time of GnRH Agonist Trigger or 35 Hours Later for the Prevention of OHSS Unknown status NCT01815138 Phase 4
8 Effect of Testosterone on Endothelial Function and Microcirculation in Type 2 Diabetic Patients With Hypogonadism Unknown status NCT01084369 Phase 4
9 Odense Androgen Study - The Effect of Testim and Training in Hypogonadal Men Unknown status NCT00700024 Phase 4
10 Testosterone Replacement in Older Men and Atherosclerosis Progression Unknown status NCT00287586 Phase 4
11 Myoinositol for the Treatment of Ovarian and Psychiatric Disorder in Polycystic Ovary Syndrome (PCOS) Patients Unknown status NCT01246310 Phase 4
12 Testosterone for Peripheral Vascular Disease Unknown status NCT00504712 Phase 4
13 the Effect of Diane-35 Pretreatment on In-vitro Fertilization Outcome for Patients With Polycystic Ovary Syndrome Unknown status NCT01752270 Phase 4
14 The Impact on Ovarian Reserve After Single-port, Two-port, or Four-port Access Laparoscopic Ovarian Cyst Enucleation Unknown status NCT01631253 Phase 4
15 Metformin and Gestational Diabetes in High-risk Patients: a RCTs Unknown status NCT00883259 Phase 4
16 Hemocoagulation and Lipoperoxidation in Women Using Combined Oral Contraceptives, Correction by Antioxidants Unknown status NCT02027337 Phase 4
17 Ethinyl Estradiol and Cyproterone Acetate in Irregular Menstruation Unknown status NCT01103518 Phase 4
18 Endometrial Scratching During Laproscopic Ovarian Drilling in Subfertile PCOS Women Unknown status NCT02140398 Phase 4
19 Strategies for Ovulation Induction in Anovulatory Infertile Patients With PCOS Unknown status NCT00461643 Phase 4
20 The Effect of Weight Loss on Anti-Müllerian Hormone Levels in Women With Polycystic Ovary Syndrome (PCOS) Unknown status NCT01475019 Phase 4
21 Therapeutic Monitoring of Metformin in Women With Polycystic Ovary Syndrome Unknown status NCT01366391 Phase 4
22 Comparison Between GnRH Agonist and GnRH Antagonist Protocols of Ovarian Stimulation in PCOS Patients Unknown status NCT00417144 Phase 4
23 Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS) Unknown status NCT00378729 Phase 4
24 Effects of ADSC Therapy in Women With POF Unknown status NCT01853501 Phase 4
25 A Study Evaluating the Effects of Lipid Lowering Treatment on Steroid Synthesis Unknown status NCT00433823 Phase 4
26 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4
27 Efficacy of Fenugreek Seed and Lespedeza Cuneata in TDS Completed NCT03057899 Phase 4
28 Study of Comprehensive Diagnosis and Treatment for Children Precocious Puberty Completed NCT02920515 Phase 4
29 The Effect of Testosteron Replacement Treatment on the Fibroblast Growth Factor-23, Asymmetric Dimethylarginine and Vitamin D Levels in the Congenital Hypogonadotropic Hypogonadism Completed NCT02111473 Phase 4
30 The Effect of Testosterone Topical Solution (LY900011) in Hypogonadal Men With Suboptimal Response to a Topical Testosterone Gel Completed NCT01893281 Phase 4
31 The Clinical Trial to Evaluate the Efficacy and Safety of Luphere Depot Inj. 3.75mg(Leuprolide Acetate 3.75mg) in Patients With Precocious Puberty Completed NCT01634321 Phase 4
32 Effects of Medications in Patients With Hypogonadism Completed NCT01601327 Phase 4
33 The Effect of Testosterone Replacement on the High Density Lipoprotein Cholesterol Subgroups Completed NCT01454011 Phase 4
34 ESPRIT Study in Hypogonadal Men Completed NCT01143818 Phase 4
35 Testosterone Replacement Therapy Decreases Plasma Paraoxonase 1 Enzyme Activity In Male Patients With Hypogonadism Completed NCT01107067 Phase 4
36 Efficacy Study for Use of Dutasteride (Avodart) With Testosterone Replacement Completed NCT00752869 Phase 4
37 Effects of Testosterone on Myocardial Repolarization Completed NCT03126656 Phase 4
38 Testosterone Therapy of Men With Type 2 Diabetes Mellitus (T2DM) Completed NCT01560546 Phase 4
39 Testosterone for Men With Insulin Treated Type 2 Diabetes Completed NCT00349362 Phase 4
40 Testosterone Replacement in Men With Diabetes and Obesity Completed NCT01127659 Phase 4
41 Endometrial Receptivity After GnRH Agonist Triggering Completed NCT01500863 Phase 4
42 Triggering of Final Oocyte Maturation With GnRHa (Buserelin) in GnRH Antagonist Cycles Completed NCT00627406 Phase 4
43 The Use of GnRH Agonist Trigger in the Prevention of OHSS Completed NCT00349258 Phase 4
44 TRADE-Testosterone Replacement and Dutasteride Effectiveness Completed NCT00194675 Phase 4
45 Gonadotrophin Dosage Using a Threshold Nomogram for Ovulation Induction in WHO Group II Anovulatory Infertility Completed NCT01250821 Phase 4
46 The Therapy of Nebido as Mono or in Combination With PDE-5 Inhibitors in Hypogonadal Patients With Erectile Dysfunction Completed NCT00421460 Phase 4
47 Endothelial Dysfunction, Inflammation and Insulin Resistance in Congenital Hypogonadism and Effect of Testosteron Replacement Therapy Completed NCT02171390 Phase 4
48 The Effect of Testosterone Replacement on Endothelial Dysfunction, Inflammation and Insulin Resistance in Male Hypogonadotrophic Hypogonadism Completed NCT01533129 Phase 4
49 Metabolic Syndrome Criteria and the Effect of Testosterone Treatment in Young Men With Hypogonadism Completed NCT01160341 Phase 4
50 Short Versus Long Protocol for IVF and IVF+ICSI Completed NCT00756028 Phase 4

Search NIH Clinical Center for Gonadal Disease

Cochrane evidence based reviews: gonadal disorders

Genetic Tests for Gonadal Disease

Anatomical Context for Gonadal Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Gonadal Disease:

18
The Gonads

Publications for Gonadal Disease

Variations for Gonadal Disease

Expression for Gonadal Disease

Search GEO for disease gene expression data for Gonadal Disease.

Pathways for Gonadal Disease

GO Terms for Gonadal Disease

Cellular components related to Gonadal Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 AMH ANOS1 CRH GH1 GHR GNRH1
2 extracellular region GO:0005576 9.36 AMH ANOS1 CRH GH1 GHR GNRH1
3 endosome lumen GO:0031904 9.26 GH1 INS
4 growth hormone receptor complex GO:0070195 9.16 GH1 GHR

Biological processes related to Gonadal Disease according to GeneCards Suite gene sharing:

(show all 26)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.98 AR CRH IGF1 INS PROK2
2 positive regulation of gene expression GO:0010628 9.85 AMH AR CRH INS NR5A1
3 male gonad development GO:0008584 9.8 AR FSHR NR5A1
4 positive regulation of MAPK cascade GO:0043410 9.77 AR IGF1 INS
5 neuropeptide signaling pathway GO:0007218 9.71 KISS1R POMC PROK2 PROKR2
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.67 GH1 GHR IGF1
7 positive regulation of cell differentiation GO:0045597 9.65 AR GHR INS
8 positive regulation of glycogen biosynthetic process GO:0045725 9.62 IGF1 INS
9 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.62 GH1 GHR
10 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.62 GH1 GHR IGF1 INS
11 positive regulation of glycolytic process GO:0045821 9.61 IGF1 INS
12 insulin-like growth factor receptor signaling pathway GO:0048009 9.61 GHR IGF1
13 hormone-mediated signaling pathway GO:0009755 9.61 FSHR GHR NR5A1
14 gonad development GO:0008406 9.6 AMH FSHR
15 male sex determination GO:0030238 9.58 GNRH1 SRY
16 positive regulation of intracellular estrogen receptor signaling pathway GO:0033148 9.57 AR FSHR
17 regulation of systemic arterial blood pressure GO:0003073 9.56 AR FSHR
18 growth hormone receptor signaling pathway GO:0060396 9.55 GH1 GHR
19 sex determination GO:0007530 9.54 AMH NR5A1
20 sex differentiation GO:0007548 9.54 AMH AR SRY
21 positive regulation of male gonad development GO:2000020 9.52 NR5A1 SRY
22 cartilage development involved in endochondral bone morphogenesis GO:0060351 9.51 GHR SHOX2
23 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.46 FSHR GH1 IGF1 INS
24 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 9.43 GH1 GHR IGF1
25 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.13 AR GH1 IGF1
26 cell-cell signaling GO:0007267 9.1 AMH AR GNRH1 INS NR5A1 POMC

Molecular functions related to Gonadal Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.17 AMH CRH GH1 GNRH1 IGF1 INS
2 insulin-like growth factor receptor binding GO:0005159 9.16 IGF1 INS
3 androgen binding GO:0005497 8.96 AR SHBG

Sources for Gonadal Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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