Aliases & Classifications for Gonadoblastoma

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 38NCIt, 33MeSH, 55SNOMED-CT
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Gonadoblastoma, Aliases & Descriptions:

Name: Gonadoblastoma 9 11 43 60


External Ids:

Disease Ontology9 DOID:3301
NCIt38 C3754
SNOMED-CT55 74751003
MeSH33 D018238

Summaries for Gonadoblastoma

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Wikipedia:63 A gonadoblastoma is a complex neoplasm composed of a mixture of gonadal elements, such as large... more...

MalaCards based summary: Gonadoblastoma is related to turner syndrome and gonadal dysgenesis, and has symptoms including gonadoblastoma, y-linked inheritance and abnormality of metabolism/homeostasis. An important gene associated with Gonadoblastoma is TSPY1 (testis specific protein, Y-linked 1). The compounds agarose and dmrt have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and prostate, and related mouse phenotypes are renal/urinary system and muscle.

Disease Ontology:9 A cell type benign neoplasm that is composed of a mixture of gonadal elements.

Related Diseases for Gonadoblastoma

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Graphical network of the top 20 diseases related to Gonadoblastoma:



Diseases related to gonadoblastoma

Symptoms for Gonadoblastoma

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HPO human phenotypes related to Gonadoblastoma:

id Description Frequency HPO Source Accession
1 gonadoblastoma HP:0000150
2 y-linked inheritance HP:0001450
3 abnormality of metabolism/homeostasis HP:0001939

Drugs & Therapeutics for Gonadoblastoma

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Drug clinical trials:

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Search NIH Clinical Center for Gonadoblastoma

Genetic Tests for Gonadoblastoma

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Anatomical Context for Gonadoblastoma

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MalaCards organs/tissues related to Gonadoblastoma:

31
Ovary, Testis, Prostate, Breast, Kidney, Testes

Animal Models for Gonadoblastoma or affiliated genes

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MGI Mouse Phenotypes related to Gonadoblastoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.4WT1, KIT, BCAM
2MP:00053698.4TSPY1, KIT, WT1
3MP:00053898.0WT1, KIT, BCAM, SRY
4MP:00107688.0WT1, KIT, BCAM, SRY

Publications for Gonadoblastoma

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Articles related to Gonadoblastoma:

(show top 50)    (show all 241)
idTitleAuthorsYear
1
WT1 Deletion Leading to Severe 46,XY Gonadal Dysgenesis, Wilms Tumor and Gonadoblastoma: Case Report. (25613702)
2015
2
Gonadoblastoma and selected other aspects of gonadal pathology in young patients with disorders of sex development. (25129544)
2014
3
The Y-located gonadoblastoma gene TSPY amplifies its own expression through a positive feedback loop in prostate cancer cells. (24583132)
2014
4
Ovarian Gonadoblastoma with Dysgerminoma in a Young Girl with 46, XX Karyotype: A Case Report. (24179931)
2013
5
Early presentation of bilateral gonadoblastoma in Turner syndrome. (23337547)
2013
6
Gonadoblastoma: Case report of two young patients with isochromosome 12p found in the dysgerminoma overgrowth component in one case. (22906432)
2012
7
FOXL2 and SOX9 distinguish the lineage of the sex cord-stromal cells in gonadoblastomas. (21682576)
2011
8
Testicular gonadoblastoma in two pet domestic rabbits (Oryctolagus cuniculus domesticus). (21908369)
2011
9
Bilateral ovarian gonadoblastoma with coexisting dysgerminoma in a girl with 46, XX karyotype. (20598061)
2010
10
46 XY pure gonadal dysgenesis with gonadoblastoma and dysgerminoma. (19472738)
2008
11
Gonadoblastoma with contralateral dysgerminoma in a young female--a case report. (16933739)
2006
12
Presence of TSPY transcript and absence of transcripts of other Y chromosomal genes in a case of microscopic gonadoblastoma. (16784771)
2006
13
Identification of germ cells at risk for neoplastic transformation in gonadoblastoma: an immunohistochemical study for OCT3/4 and TSPY. (15948118)
2005
14
Gonadoblastoma in Turner syndrome and Y-chromosome-derived material. (15880570)
2005
15
Bilateral gonadoblastomas in a dog with mixed gonadal dysgenesis. (15003485)
2004
16
Seminoma and a gonadoblastoma in an infant with mixed gonadal dysgenesis. (12915842)
2003
17
Gonadoblastoma in androgen insensitivity syndrome: a case report. (12841671)
2003
18
Molecular breakpoint analysis and relevance of variable mosaicism in a woman with short stature, primary amenorrhea, unilateral gonadoblastoma, and a 46,X,del(Y)(q11)/45,X karyotype. (12239720)
2002
19
A case of XY pure gonadal dysgenesis with 46,XYp-/47,XXYp- karyotype whose gonadoblastoma was removed laparoscopically. (11014948)
2000
20
Heterogeneity of gonadoblastoma germ cells: similarities with immature germ cells, spermatogonia and testicular carcinoma in situ cells. (9190360)
1997
21
Gonadoblastoma with dysgerminoma in one ovary and gonadoblastoma with dysgerminoma and yolk sac tumor in the contralateral ovary in a girl with 46XX karyotype. (7789879)
1995
22
XY gonadal dysgenesis and gonadoblastoma: a study in two sisters with a cryptic deletion of the Y chromosome involving the SRY gene. (7814028)
1995
23
The association of ovarian dysgerminoma and gonadoblastoma in a phenotypic female with 46 XY karyotype. (8005142)
1994
24
Gonadoblastoma and dysgerminoma associated with 46,XY pure gonadal dysgenesis--a case report. (8305146)
1993
25
Gonadoblastoma and fertility. (1401220)
1992
26
Successful therapy of metastatic embryonal carcinoma coexisting with gonadoblastoma in a patient with 46,XY pure gonadal dysgenesis (Swyer's syndrome). (2190872)
1990
27
Gonadoblastoma in an anatomically normal man: a case report and literature review. (2231948)
1990
28
46,XY pure gonadal dysgenesis with gonadoblastoma. (2592807)
1989
29
Gonadoblastoma. Immunohistochemical and ultrastructural observations. (2707955)
1989
30
Hypothesis: a Y-chromosomal gene causes gonadoblastoma in dysgenetic gonads. (3503713)
1987
31
Dysgerminoma--gonadoblastoma and familial 46XY pure gonadal dysgenesis: case report and review of the genetics and pathophysiology of gonadal dysgenesis and H-Y antigen. (6959618)
1982
32
A canine testicular tumor resembling gonadoblastoma. (7467079)
1981
33
Mixed germ cell-sex cord stromal tumor. A gonadal tumor distinct from gonadoblastoma. (7223719)
1981
34
Pure gonadal dysgenesis with microscopic ovarian streak and gonadoblastoma. (7243126)
1981
35
Gonadoblastoma and dysgerminoma in a true hermaphrodite with a 46,XX karyotype. (7246672)
1981
36
46, XY gonadal dysgenesis with secondary amenorrhea, virilization, and bilateral gonadoblastomas. (572994)
1979
37
The paradox of the XY oocyte. Relationship to risk of gonadoblastoma in infant girls. (433847)
1979
38
Bilateral gonadoblastoma in a phenotypic female with 45,X/46,X, dicentric iso Y [45,X/46,X,idic(Yq)] mosaicism. (569512)
1978
39
Bilateral gonadoblastoma with chromosomal aberration. (876538)
1977
40
Gonadoblastoma and dysgerminoma with ataxia-telangiectasia. (990441)
1976
41
Gonadoblastoma in a true hermaphrodite with a 46,XX karyotype. (1250564)
1976
42
Ultrastructure of gonadoblastoma. (1167443)
1975
43
45,X/46,XY/47,XYY mosaicism in a phenotypic female with gonadoblastoma. (4469141)
1974
44
Gonadoblastoma associated with embryonal carcinoma. (4808955)
1974
45
Tumors of dysgenetic gonads (gonadoblastoma): ultrastructural and steroidogenic aspects. (4278968)
1974
46
Y ring chromosome associated with gonadoblastoma in situ. (4708485)
1973
47
Bilateral gonadoblastoma with dysgerminoma. A case report. (5057796)
1972
48
Gonadoblastoma and dysgerminoma in two siblings with dysgenetic gonads. (5094323)
1971
49
Gonadoblastoma. A review of 74 cases. (4193741)
1970
50
SIGNIFICANCE OF CHROMOSOMAL INVESTIGATION OF SOMATIC CELLS TO DETERMINE THE GENETIC ORIGIN OF GONADOBLASTOMA: GONOCYTOMA 3. (14185488)
1964

Variations for Gonadoblastoma

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Expression for genes affiliated with Gonadoblastoma

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Search GEO for disease gene expression data for Gonadoblastoma.

Pathways for genes affiliated with Gonadoblastoma

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Compounds for genes affiliated with Gonadoblastoma

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Compounds related to Gonadoblastoma according to GeneCards Suite gene sharing:

(show all 11)
idCompoundScoreTop Affiliating Genes
1agarose439.4KIT, SRY
2dmrt439.4WT1, SRY
3deoxyribonucleic acid439.4WT1, SRY
4vincristine43 49 1211.2KIT, WT1
5adenine43 24 1211.2WT1, SRY
6ribonucleic acid439.1WT1, KIT
7imatinib43 49 1210.8WT1, KIT
8testosterone43 59 24 1211.8WT1, KIT, SRY
9steroid438.8SRY, KIT, WT1
10oligonucleotide438.8WT1, KIT, SRY
11cysteine438.5SRY, KIT, WT1

GO Terms for genes affiliated with Gonadoblastoma

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Cellular components related to Gonadoblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.3KIT, BCAM
2nuclear speckGO:00166078.8WT1, SRY

Biological processes related to Gonadoblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sex differentiationGO:00075489.4SRY, TSPY1
2positive regulation of male gonad developmentGO:020000209.1WT1, SRY
3regulation of transcription from RNA polymerase II promoterGO:00063579.1WT1, SRY
4male gonad developmentGO:00085848.8WT1, KIT

Products for genes affiliated with Gonadoblastoma

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Sources for Gonadoblastoma

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3CDC
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23HGMD
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25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
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35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet