Aliases & Classifications for Gonadoblastoma

About this section

Aliases & Descriptions for Gonadoblastoma:

Name: Gonadoblastoma 10 47 12 36 65

Characteristics:

HPO:

61


Classifications:



External Ids:

Disease Ontology10 DOID:3301
MeSH36 D018238
SNOMED-CT59 74751003
NCIt42 C3754
UMLS65 C0206661

Summaries for Gonadoblastoma

About this section
Wikipedia:68 A gonadoblastoma is a complex neoplasm composed of a mixture of gonadal elements, such as large... more...

MalaCards based summary: Gonadoblastoma is related to seminoma and 46 xy gonadal dysgenesis, and has symptoms including abnormality of metabolism/homeostasisand gonadoblastoma. An important gene associated with Gonadoblastoma is TSPY1 (Testis Specific Protein, Y-Linked 1), and among its related pathways is Folate biosynthesis. Affiliated tissues include breast, ovary and prostate, and related mouse phenotype reproductive system.

Disease Ontology:10 A cell type benign neoplasm that is composed of a mixture of gonadal elements.

Related Diseases for Gonadoblastoma

About this section

Diseases related to Gonadoblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 134)
idRelated DiseaseScoreTop Affiliating Genes
1seminoma30.4ALPP, ALPPL2
246 xy gonadal dysgenesis29.9FOXL2, SRY, TSPY1
3ovarian gonadoblastoma12.2
4testicular gonadoblastoma12.1
5wagr syndrome11.3
6frasier syndrome10.6
7testicular spermatocytic seminoma10.6SRY, TSPY1
8gonadal dysgenesis10.6
9swyer-james syndrome10.5SRY, TSPY1
1046 xx gonadal dysgenesis10.5FOXL2, SRY
11breast-ovarian cancer, familial, 210.4FOXL2, SRY
12nephrotic syndrome, type 410.2SRY, WT1
13ovary leiomyosarcoma10.2KIT, WT1
14turner syndrome10.2
15osteogenesis imperfecta-retinopathy-seizures-intellectual disability syndrome10.2KIT, WT1
16anaerobic meningitis10.2ALPP, ALPPL2
17breast adenocarcinoma10.2ALPP, ALPPL2
18cervical adenitis10.2ALPP, ALPPL2
19internal auditory canal meningioma10.2ALPP, ALPPL2
20malignant histiocytosis10.2ALPP, ALPPL2
21angiostrongyliasis10.2ALPP, ALPPL2
22rapidly progressive glomerulonephritis10.2KIT, WT1
23achondrogenesis10.2ALPP, ALPPL2
24arteritic anterior ischemic optic neuropathy10.2ALPP, ALPPL2
25fibrogenesis imperfecta ossium10.2ALPP, ALPPL2
26mixed cell type adenoma of parathyroid10.2ALPP, ALPPL2
27xanthogranulomatous cholecystitis10.2ALPP, ALPPL2
28axial osteomalacia10.2ALPP, ALPPL2
29brawny scleritis10.2ALPP, ALPPL2
30larynx carcinoma in situ10.2ALPP, ALPPL2
31swine influenza10.2ALPP, ALPPL2
32gingival disease10.2ALPP, ALPPL2
33sebaceous breast carcinoma10.2KIT, WT1
34bartholin's gland adenocarcinoma10.2ALPP, ALPPL2
35central nervous system germ cell tumor10.2ALPP, ALPPL2
36venezuelan hemorrhagic fever10.2ALPP, ALPPL2
37diamond-blackfan anemia 410.2ALPP, ALPPL2
38alzheimer disease-210.2ALPP, ALPPL2
39paracoccidioidomycosis10.1ALPP, ALPPL2
40central nervous system sarcoma10.1ALPP, ALPPL2
41bile duct disease10.1ALPP, ALPPL2
42disease of mental health10.1FOXL2, SRY
43biliary tract disease10.1ALPP, ALPPL2
44leber congenital amaurosis 310.1ALPP, ALPPL2
45uremia10.1ALPP, ALPPL2
46splenic flexure cancer10.1ALPP, ALPPL2
47uveal diseases10.1KIT, WT1
48amebiasis10.1ALPP, ALPPL2
49duodenogastric reflux10.1ALPP, ALPPL2
50hernia of ovary and fallopian tube10.1ALPP, ALPPL2

Graphical network of the top 20 diseases related to Gonadoblastoma:



Diseases related to gonadoblastoma

Symptoms for Gonadoblastoma

About this section

HPO human phenotypes related to Gonadoblastoma:

id Description Frequency HPO Source Accession
1 abnormality of metabolism/homeostasis HP:0001939
2 gonadoblastoma HP:0000150

Drugs & Therapeutics for Gonadoblastoma

About this section

Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Gonadoblastoma


Cochrane evidence based reviews: gonadoblastoma

Genetic Tests for Gonadoblastoma

About this section

Anatomical Context for Gonadoblastoma

About this section

MalaCards organs/tissues related to Gonadoblastoma:

33
Breast, Ovary, Prostate, Endothelial, Liver, Thyroid, Kidney

Animal Models for Gonadoblastoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Gonadoblastoma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053897.4ALPPL2, FOXL2, KIT, SLC22A3, TSPYL2, WT1

Publications for Gonadoblastoma

About this section

Articles related to Gonadoblastoma:

(show top 50)    (show all 249)
idTitleAuthorsYear
1
Occurrence of Gonadoblastoma in Patients with 45,X/46,XY Mosaicism. (26046609)
2015
2
WT1 Deletion Leading to Severe 46,XY Gonadal Dysgenesis, Wilms Tumor and Gonadoblastoma: Case Report. (25613702)
2015
3
Gonadoblastoma and selected other aspects of gonadal pathology in young patients with disorders of sex development. (25129544)
2014
4
Ovarian Gonadoblastoma with Dysgerminoma in a Young Girl with 46, XX Karyotype: A Case Report. (24179931)
2013
5
Early presentation of bilateral gonadoblastoma in Turner syndrome. (23337547)
2013
6
Gonadoblastoma: Case report of two young patients with isochromosome 12p found in the dysgerminoma overgrowth component in one case. (22906432)
2012
7
FOXL2 and SOX9 distinguish the lineage of the sex cord-stromal cells in gonadoblastomas. (21682576)
2011
8
Testicular gonadoblastoma in two pet domestic rabbits (Oryctolagus cuniculus domesticus). (21908369)
2011
9
Bilateral ovarian gonadoblastoma with coexisting dysgerminoma in a girl with 46, XX karyotype. (20598061)
2010
10
46 XY pure gonadal dysgenesis with gonadoblastoma and dysgerminoma. (19472738)
2008
11
Gonadoblastoma with contralateral dysgerminoma in a young female--a case report. (16933739)
2006
12
Presence of TSPY transcript and absence of transcripts of other Y chromosomal genes in a case of microscopic gonadoblastoma. (16784771)
2006
13
Successful pregnancy in a gonadectomized woman with 46,XY gonadal dysgenesis and gonadoblastoma. (16009184)
2005
14
Identification of germ cells at risk for neoplastic transformation in gonadoblastoma: an immunohistochemical study for OCT3/4 and TSPY. (15948118)
2005
15
Gonadoblastoma in Turner syndrome and Y-chromosome-derived material. (15880570)
2005
16
Bilateral gonadoblastomas in a dog with mixed gonadal dysgenesis. (15003485)
2004
17
Seminoma and a gonadoblastoma in an infant with mixed gonadal dysgenesis. (12915842)
2003
18
Gonadoblastoma in androgen insensitivity syndrome: a case report. (12841671)
2003
19
A case of XY pure gonadal dysgenesis with 46,XYp-/47,XXYp- karyotype whose gonadoblastoma was removed laparoscopically. (11014948)
2000
20
Heterogeneity of gonadoblastoma germ cells: similarities with immature germ cells, spermatogonia and testicular carcinoma in situ cells. (9190360)
1997
21
Gonadoblastoma with dysgerminoma in one ovary and gonadoblastoma with dysgerminoma and yolk sac tumor in the contralateral ovary in a girl with 46XX karyotype. (7789879)
1995
22
XY gonadal dysgenesis and gonadoblastoma: a study in two sisters with a cryptic deletion of the Y chromosome involving the SRY gene. (7814028)
1995
23
The association of ovarian dysgerminoma and gonadoblastoma in a phenotypic female with 46 XY karyotype. (8005142)
1994
24
Gonadoblastoma and dysgerminoma associated with 46,XY pure gonadal dysgenesis--a case report. (8305146)
1993
25
Gonadoblastoma and fertility. (1401220)
1992
26
Successful therapy of metastatic embryonal carcinoma coexisting with gonadoblastoma in a patient with 46,XY pure gonadal dysgenesis (Swyer's syndrome). (2190872)
1990
27
Gonadoblastoma in an anatomically normal man: a case report and literature review. (2231948)
1990
28
46,XY pure gonadal dysgenesis with gonadoblastoma. (2592807)
1989
29
Gonadoblastoma. Immunohistochemical and ultrastructural observations. (2707955)
1989
30
Hypothesis: a Y-chromosomal gene causes gonadoblastoma in dysgenetic gonads. (3503713)
1987
31
Dysgerminoma--gonadoblastoma and familial 46XY pure gonadal dysgenesis: case report and review of the genetics and pathophysiology of gonadal dysgenesis and H-Y antigen. (6959618)
1982
32
A canine testicular tumor resembling gonadoblastoma. (7467079)
1981
33
Mixed germ cell-sex cord stromal tumor. A gonadal tumor distinct from gonadoblastoma. (7223719)
1981
34
Pure gonadal dysgenesis with microscopic ovarian streak and gonadoblastoma. (7243126)
1981
35
Gonadoblastoma and dysgerminoma in a true hermaphrodite with a 46,XX karyotype. (7246672)
1981
36
46, XY gonadal dysgenesis with secondary amenorrhea, virilization, and bilateral gonadoblastomas. (572994)
1979
37
The paradox of the XY oocyte. Relationship to risk of gonadoblastoma in infant girls. (433847)
1979
38
Bilateral gonadoblastoma in a phenotypic female with 45,X/46,X, dicentric iso Y [45,X/46,X,idic(Yq)] mosaicism. (569512)
1978
39
Bilateral gonadoblastoma with chromosomal aberration. (876538)
1977
40
Gonadoblastoma and dysgerminoma with ataxia-telangiectasia. (990441)
1976
41
Gonadoblastoma in a true hermaphrodite with a 46,XX karyotype. (1250564)
1976
42
Ultrastructure of gonadoblastoma. (1167443)
1975
43
45,X/46,XY/47,XYY mosaicism in a phenotypic female with gonadoblastoma. (4469141)
1974
44
Gonadoblastoma associated with embryonal carcinoma. (4808955)
1974
45
Tumors of dysgenetic gonads (gonadoblastoma): ultrastructural and steroidogenic aspects. (4278968)
1974
46
Y ring chromosome associated with gonadoblastoma in situ. (4708485)
1973
47
Bilateral gonadoblastoma with dysgerminoma. A case report. (5057796)
1972
48
Gonadoblastoma and dysgerminoma in two siblings with dysgenetic gonads. (5094323)
1971
49
Gonadoblastoma. A review of 74 cases. (4193741)
1970
50
SIGNIFICANCE OF CHROMOSOMAL INVESTIGATION OF SOMATIC CELLS TO DETERMINE THE GENETIC ORIGIN OF GONADOBLASTOMA: GONOCYTOMA 3. (14185488)
1964

Variations for Gonadoblastoma

About this section

Expression for genes affiliated with Gonadoblastoma

About this section
Search GEO for disease gene expression data for Gonadoblastoma.

Pathways for genes affiliated with Gonadoblastoma

About this section

Pathways related to Gonadoblastoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.3ALPP, ALPPL2

GO Terms for genes affiliated with Gonadoblastoma

About this section

Biological processes related to Gonadoblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1sex determinationGO:00075309.7SRY, WT1

Sources for Gonadoblastoma

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet