MCID: GND001
MIFTS: 43

Gonadoblastoma malady

Cancer diseases category
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Summaries for Gonadoblastoma

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Wikipedia:65 A gonadoblastoma is a complex neoplasm composed of a mixture of gonadal elements, such as large... more...

MalaCards based summary: Gonadoblastoma is related to gonadal dysgenesis and turner syndrome. An important gene associated with Gonadoblastoma is TSPY1 (testis specific protein, Y-linked 1). The compounds agarose and dmrt have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and breast, and related mouse phenotypes are renal/urinary system and muscle.

Disease Ontology:8 A cell type benign neoplasm that is composed of a mixture of gonadal elements.

Description from OMIM:46 424500

Aliases & Classifications for Gonadoblastoma

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 39NCIt, 46OMIM
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Gonadoblastoma, Aliases & Descriptions:

Name: Gonadoblastoma 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:3301
MeSH34 D018238
SNOMED-CT57 74751003
NCIt39 C3754
OMIM46 424500

Related Diseases for Gonadoblastoma

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Graphical network of the top 20 diseases related to Gonadoblastoma:



Diseases related to gonadoblastoma

Symptoms for Gonadoblastoma

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Clinical features from OMIM:

424500

Drugs & Therapeutics for Gonadoblastoma

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Drug clinical trials:

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Search NIH Clinical Center for Gonadoblastoma

Genetic Tests for Gonadoblastoma

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Anatomical Context for Gonadoblastoma

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MalaCards organs/tissues related to Gonadoblastoma:

32
Ovary, Testis, Breast, Kidney, Prostate, Testes

Animal Models for Gonadoblastoma or affiliated genes

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MGI Mouse Phenotypes related to Gonadoblastoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.4WT1, KIT, BCAM
2MP:00053698.4TSPY1, KIT, WT1
3MP:00053898.0WT1, KIT, BCAM, SRY
4MP:00107688.0WT1, KIT, BCAM, SRY

Publications for Gonadoblastoma

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Articles related to Gonadoblastoma:

(show top 50)    (show all 238)
idTitleAuthorsYear
1
Gonadoblastoma and selected other aspects of gonadal pathology in young patients with disorders of sex development. (25129544)
2014
2
Ovarian Gonadoblastoma with Dysgerminoma in a Young Girl with 46, XX Karyotype: A Case Report. (24179931)
2013
3
Early presentation of bilateral gonadoblastoma in Turner syndrome. (23337547)
2013
4
Gonadoblastoma: Case report of two young patients with isochromosome 12p found in the dysgerminoma overgrowth component in one case. (22906432)
2012
5
Ovarian gonadoblastoma with dysgerminoma in a 15-year-old girl with 46, XX karyotype: case report and review of the literature. (21879333)
2012
6
FOXL2 and SOX9 distinguish the lineage of the sex cord-stromal cells in gonadoblastomas. (21682576)
2011
7
Testicular gonadoblastoma in two pet domestic rabbits (Oryctolagus cuniculus domesticus). (21908369)
2011
8
Bilateral ovarian gonadoblastoma with coexisting dysgerminoma in a girl with 46, XX karyotype. (20598061)
2010
9
The chromosome Y-linked testis-specific protein locus TSPY1 is characteristically present in gonadoblastoma. (20656323)
2010
10
46 XY pure gonadal dysgenesis with gonadoblastoma and dysgerminoma. (19472738)
2008
11
Gonadoblastoma with contralateral dysgerminoma in a young female--a case report. (16933739)
2006
12
Presence of TSPY transcript and absence of transcripts of other Y chromosomal genes in a case of microscopic gonadoblastoma. (16784771)
2006
13
Successful pregnancy in a gonadectomized woman with 46,XY gonadal dysgenesis and gonadoblastoma. (16009184)
2005
14
Identification of germ cells at risk for neoplastic transformation in gonadoblastoma: an immunohistochemical study for OCT3/4 and TSPY. (15948118)
2005
15
Gonadoblastoma in Turner syndrome and Y-chromosome-derived material. (15880570)
2005
16
Gonadoblastoma with unusual mixed germ cell overgrowth--a case report. (16761761)
2005
17
Bilateral gonadoblastomas in a dog with mixed gonadal dysgenesis. (15003485)
2004
18
Seminoma and a gonadoblastoma in an infant with mixed gonadal dysgenesis. (12915842)
2003
19
Gonadoblastoma in androgen insensitivity syndrome: a case report. (12841671)
2003
20
Molecular breakpoint analysis and relevance of variable mosaicism in a woman with short stature, primary amenorrhea, unilateral gonadoblastoma, and a 46,X,del(Y)(q11)/45,X karyotype. (12239720)
2002
21
A case of XY pure gonadal dysgenesis with 46,XYp-/47,XXYp- karyotype whose gonadoblastoma was removed laparoscopically. (11014948)
2000
22
Heterogeneity of gonadoblastoma germ cells: similarities with immature germ cells, spermatogonia and testicular carcinoma in situ cells. (9190360)
1997
23
Gonadoblastoma with dysgerminoma in one ovary and gonadoblastoma with dysgerminoma and yolk sac tumor in the contralateral ovary in a girl with 46XX karyotype. (7789879)
1995
24
XY gonadal dysgenesis and gonadoblastoma: a study in two sisters with a cryptic deletion of the Y chromosome involving the SRY gene. (7814028)
1995
25
The association of ovarian dysgerminoma and gonadoblastoma in a phenotypic female with 46 XY karyotype. (8005142)
1994
26
Gonadoblastoma and dysgerminoma associated with 46,XY pure gonadal dysgenesis--a case report. (8305146)
1993
27
Gonadoblastoma and fertility. (1401220)
1992
28
Successful therapy of metastatic embryonal carcinoma coexisting with gonadoblastoma in a patient with 46,XY pure gonadal dysgenesis (Swyer's syndrome). (2190872)
1990
29
Gonadoblastoma in an anatomically normal man: a case report and literature review. (2231948)
1990
30
46,XY pure gonadal dysgenesis with gonadoblastoma. (2592807)
1989
31
Gonadoblastoma. Immunohistochemical and ultrastructural observations. (2707955)
1989
32
Hypothesis: a Y-chromosomal gene causes gonadoblastoma in dysgenetic gonads. (3503713)
1987
33
A canine testicular tumor resembling gonadoblastoma. (7467079)
1981
34
Mixed germ cell-sex cord stromal tumor. A gonadal tumor distinct from gonadoblastoma. (7223719)
1981
35
Pure gonadal dysgenesis with microscopic ovarian streak and gonadoblastoma. (7243126)
1981
36
Gonadoblastoma and dysgerminoma in a true hermaphrodite with a 46,XX karyotype. (7246672)
1981
37
46, XY gonadal dysgenesis with secondary amenorrhea, virilization, and bilateral gonadoblastomas. (572994)
1979
38
The paradox of the XY oocyte. Relationship to risk of gonadoblastoma in infant girls. (433847)
1979
39
Bilateral gonadoblastoma in a phenotypic female with 45,X/46,X, dicentric iso Y [45,X/46,X,idic(Yq)] mosaicism. (569512)
1978
40
Bilateral gonadoblastoma with chromosomal aberration. (876538)
1977
41
Gonadoblastoma and dysgerminoma with ataxia-telangiectasia. (990441)
1976
42
Gonadoblastoma in a true hermaphrodite with a 46,XX karyotype. (1250564)
1976
43
Ultrastructure of gonadoblastoma. (1167443)
1975
44
Gonadoblastoma associated with embryonal carcinoma. (4808955)
1974
45
Tumors of dysgenetic gonads (gonadoblastoma): ultrastructural and steroidogenic aspects. (4278968)
1974
46
Y ring chromosome associated with gonadoblastoma in situ. (4708485)
1973
47
Bilateral gonadoblastoma with dysgerminoma. A case report. (5057796)
1972
48
Gonadoblastoma and dysgerminoma in two siblings with dysgenetic gonads. (5094323)
1971
49
Gonadoblastoma. A review of 74 cases. (4193741)
1970
50
SIGNIFICANCE OF CHROMOSOMAL INVESTIGATION OF SOMATIC CELLS TO DETERMINE THE GENETIC ORIGIN OF GONADOBLASTOMA: GONOCYTOMA 3. (14185488)
1964

Variations for Gonadoblastoma

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Expression for genes affiliated with Gonadoblastoma

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Expression patterns in normal tissues for genes affiliated with Gonadoblastoma

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Pathways for genes affiliated with Gonadoblastoma

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Compounds for genes affiliated with Gonadoblastoma

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Compounds related to Gonadoblastoma according to GeneCards/GeneDecks:

(show all 11)
idCompoundScoreTop Affiliating Genes
1agarose449.4KIT, SRY
2dmrt449.4WT1, SRY
3deoxyribonucleic acid449.4WT1, SRY
4vincristine44 50 1111.2KIT, WT1
5adenine44 24 1111.2WT1, SRY
6ribonucleic acid449.1WT1, KIT
7imatinib44 50 1110.8WT1, KIT
8testosterone44 61 24 1111.8WT1, KIT, SRY
9steroid448.8SRY, KIT, WT1
10oligonucleotide448.8WT1, KIT, SRY
11cysteine448.5SRY, KIT, WT1

GO Terms for genes affiliated with Gonadoblastoma

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Cellular components related to Gonadoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3KIT, BCAM
2nuclear speckGO:0166078.8WT1, SRY

Biological processes related to Gonadoblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sex differentiationGO:0075489.4SRY, TSPY1
2positive regulation of male gonad developmentGO:20000209.1WT1, SRY
3regulation of transcription from RNA polymerase II promoterGO:0063579.1WT1, SRY
4male gonad developmentGO:0085848.8WT1, KIT

Products for genes affiliated with Gonadoblastoma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Gonadoblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet