Gonadotropin Deficiency malady

Wikipedia: Hypogonadism is a medical term which describes a diminished functional activity of the gonads – the...⁴⁴ more...

MalaCards: Gonadotropin Deficiency, also known as hypogonadotropic hypogonadism, is related to hypogonadotropism and hypogonadism. An important gene associated with Gonadotropin Deficiency is HESX1 (HESX homeobox 1), and among its related pathways are Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q and GnRH signaling pathway. The compounds sodium nitroprusside and degarelix have been mentioned in the context of this disorder. Affiliated tissues include ovary, and related mouse phenotypes are liver/biliary system and integument.

gonadotropin deficiency 7 hypogonadotropic hypogonadism 43

Diseases related to gonadotropin deficiency by text searches and GeneDecks gene sharing:

(show top 50)    (show all 214)

id	Related Disease	Score	Top Affiliating Genes
1	hypogonadotropism	34.4	PROKR2, PRL, KISS1R, CGA, KAL1, FGFR1
2	hypogonadism	32.6	KISS1R, CGA, KAL1, FSHR, FGFR1, GNRH1
3	klinefelter's syndrome	32.5	GNRHR, FGFR1, KISS1R
4	kallmann syndrome	32.3	KISS1R, CGA, KAL1, FGFR1, GNRH1, GNRHR
5	kallmann syndrome 1	31.8	KAL1, FGFR1
6	anosmia	30.6	PROKR2, PROK2, GNRHR, FGFR1, KAL1
7	premature ejaculation	28.8	CYP19A1, PRL
8	ichthyosis	28.7	CGA, KAL1, SOD1
9	cerebellar hypoplasia	28.3	HESX1, GH1, FSHR, KAL1
10	craniopharyngioma	27.8	PRL, HESX1, GH1, CGA
11	male infertility	27.7	SOD1, CYP19A1, GNRH1, FSHR, CGA
12	anophthalmia	26.9	SOD1, PRL, HESX1
13	growth hormone deficiency	26.5	SOD1, PRL, HESX1, CYP19A1, GH1, GNRH1
14	infertility	25.5	SOD1, PRL, CYP19A1, GH1, GNRHR, GNRH1
15	cryptorchidism	24.5	CYP19A1, HESX1, PROKR2, SOD1, GNRHR, GNRH1
16	obesity	24.5	SOD1, PRL, HESX1, CYP19A1, GH1, GNRH1
17	delayed puberty	22.4	CGA, KAL1, FSHR, FGFR1, GNRH1, GNRHR
18	leydig cell adenoma	13.3	GNRH1, CGA
19	septooptic dysplasia	13.2	HESX1, SOD1
20	primary ciliary dyskinesia	13.2	CGA, CYP19A1
21	complete androgen insensitivity syndrome	13.1	CYP19A1, CGA
22	micropenis	13.1	CGA, GNRH1
23	testotoxicosis	13.0	CYP19A1, FSHR
24	precocious puberty, male	13.0	FSHR, CYP19A1
25	ectopic pregnancy	13.0	PROKR2, GNRH1, CGA
26	myoma	12.9	CYP19A1, GNRHR, GNRH1
27	uterine fibroid	12.9	CYP19A1, GNRHR, GNRH1
28	ovarian cyst	12.9	CYP19A1, GNRH1, CGA
29	nephropathic cystinosis	12.9	GH1, CGA
30	virilization	12.9	CYP19A1, GNRH1, CGA
31	prostate disease	12.8	CYP19A1, GH1
32	sexual disorder	12.8	GNRH1, PRL
33	neuromuscular disease	12.8	SOD1, GNRHR, GNRH1
34	testicular disease	12.8	PRL, GNRH1
35	isolated growth hormone deficiency	12.8	HESX1, GH1
36	arachnoid cysts	12.8	GNRH1, GH1
37	neurogenic diabetes insipidus	12.8	GNRH1, PRL
38	growth disorders	12.7	GH1, CYP19A1
39	endogenous depression	12.7	PRL, GNRH1
40	robinow syndrome	12.7	GH1, GNRH1, CGA
41	hypothalamic hamartomas	12.7	PRL, GNRH1
42	tooth agenesis	12.7	PROKR2, PROK2, FGFR1, KAL1
43	renal agenesis	12.7	PROKR2, PROK2, FGFR1, KAL1
44	aromatase deficiency	12.7	GNRH1, GH1, CYP19A1
45	thyrotoxicosis	12.7	CGA, GNRH1, GH1
46	aorta atresia	12.6	CYP19A1, GNRHR, GNRH1, CGA
47	stickler syndrome	12.6	KAL1, FGFR1, PROK2, PROKR2
48	breast pericanalicular fibroadenoma	12.6	PRL, CYP19A1
49	myelomeningocele	12.6	GNRH1, PRL
50	beta thalassemia	12.6	SOD1, GNRH1, CGA

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to gonadotropin deficiency:

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MGI Mouse Phenotypes related to gonadotropin deficiency:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system phenotype	MP:0005370	8.0	PRL, CYP19A1, GH1, GNRH1, KISS1R, SOD1
2	integument phenotype	MP:0010771	6.9	PROKR2, GNRHR, GNRH1, FSHR, KISS1R, FGFR1
3	reproductive system phenotype	MP:0005389	6.2	GNRH1, GNRHR, GH1, CYP19A1, PRL, PROKR2
4	homeostasis/metabolism phenotype	MP:0005376	6.1	GNRHR, KISS1R, CGA, FSHR, GNRH1, GH1
5	growth/size phenotype	MP:0005378	6.0	CGA, FSHR, PROKR2, FGFR1, GNRH1, GNRHR
6	nervous system phenotype	MP:0003631	5.5	PROK2, PRL, PROKR2, SOD1, CYP19A1, GH1
7	endocrine/exocrine gland phenotype	MP:0005379	5.5	CGA, KISS1R, PROKR2, PRL, HESX1, CYP19A1

Articles related to gonadotropin deficiency:

id	Title	Authors	Year	Affiliating Genes
1	Genetics defects in GNRH1: a paradigm of hypothalamic congenital gonadotropin deficiency. (20887715)	Bouligand J.... Young J.	2010	GNRH1
2	Genetic insights into human isolated gonadotropin deficiency. (17624596)	Trarbach E.B.... Latronico A.C.	2007	FGFR1, GNRHR, KAL1
3	Evolution of gonadotropin deficiency in a patient with type II autosomal dominant GH deficiency. (17132747)	Turton J.P.... Dattani M.T.	2006	GH1
4	Luteinizing hormone receptor-mediated effects on init iation of spermatogenesis in gonadotropin-deficient (hpg) mice are replicated b y testosterone. (12954730)	Spaliviero J.A.... Handelsman D.J.	2004	CGA
5	A case of growth hormone and gonadotropin deficiency associated with unilateral anophthalmia, microphallus, cryptorchidism, and mental retardation. (12008745)	Miyako K.... Hara T.	2002	SOD1, HESX1
6	An activated human follicle-stimulating hormone (FSH) receptor stimulates FSH-like activity in gonadotropin-deficient transgenic mice. (12403847)	Haywood M.... Allan C.M.	2002	FSHR
7	The role of TRH-stimulated prolactin responses in distinguishing gonadotropin deficiency from constitutional delayed puberty. (7735370)	BA1yA1kgebiz A.... Oktay S.	1994	PRL, GNRH1
8	Human recombinant follicle-stimulating hormone induce s growth of preovulatory follicles without concomitant increase in androgen and estrogen biosynthesis in a woman with isolated gonadotropin deficiency. (1592896)	Schoot D.C.... Fauser B.C.	1992	CYP19A1

Genes related to gonadotropin deficiency according to GeneCards:

(show all 14)

id	Symbol	Description	Score	GeneCards Section Context
1	HESX1	HESX homeobox 1	11.0	Publications
2	PROK2	prokineticin 2	11.0	Publications
3	KISS1R	KISS1 receptor	11.0	Publications
4	PROKR2	prokineticin receptor 2	11.0	Publications
5	GNRHR	gonadotropin-releasing hormone receptor	11.0	Publications
6	KAL1	Kallmann syndrome 1 sequence	11.0	Publications
7	GNRH1	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)	11.0	Publications
8	PRL	prolactin	11.0	Publications
9	SOD1	superoxide dismutase 1, soluble	11.0	Publications
10	CGA	glycoprotein hormones, alpha polypeptide	11.0	Publications
11	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1	11.0	Publications
12	FGFR1	fibroblast growth factor receptor 1	11.0	Publications
13	FSHR	follicle stimulating hormone receptor	11.0	Publications
14	GH1	growth hormone 1	11.0	Publications

Pathways related to gonadotropin deficiency according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q10	9.4	PROKR2, PROK2, KISS1R
2	GnRH signaling pathway20	9.3	GNRH1, CGA, GNRHR
3	G alpha (q) signalling events38	9.2	PROK2, PROKR2, GNRHR, GNRH1, KISS1R
4	Development Role of Activin A in cell differentiation and proliferation10	9.0	FSHR, GNRHR, CGA
5	Development_Role of Activin A in cell differentiation and proliferation41	8.9	CGA, FSHR, GNRHR
6	JAK-STAT Pathway36	8.6	PRL, GH1, GNRH1, FGFR1
7	Neuroactive ligand-receptor interaction20	7.8	PRL, GH1, GNRHR, FSHR, CGA, KISS1R

Compounds related to gonadotropin deficiency according to GeneDecks:

(show top 50)    (show all 89)

id	Compound	Score	Top Affiliating Genes
1	sodium nitroprusside32	10.2	CGA
2	degarelix32 9 9	11.9	GNRH1, GNRHR
3	toremifene32 9 9	11.8	CYP19A1, PRL
4	altrenogest32	9.8	GNRH1, CGA
5	antarelix32	9.8	CGA, GNRH1, GNRHR
6	ganirelix32	9.8	GNRH1, CGA, GNRHR
7	d-trp6-lhrh32	9.7	GNRHR, CGA, GNRH1
8	cetrorelix32 9 9	11.7	GNRH1, CGA, GNRHR
9	metrodin32	9.7	GNRH1, CGA
10	pergonal32	9.6	CGA, GNRH1
11	naltrexone32 34 9 9	12.4	GNRH1, GH1, PRL
12	leuprolide32 42 9 9	12.4	CGA, GNRH1, GNRHR, PRL
13	cyproteroneacetate32	9.4	PRL, GNRH1, CYP19A1
14	deslorelin32	9.4	CGA, GNRH1
15	danazol32 9 18 9	12.3	GNRHR, PRL, GNRH1, CYP19A1
16	nafarelin32 42 9 9	12.3	GNRHR, GNRH1, CYP19A1, CGA
17	goserelin32 9 9	11.3	GNRHR, GNRH1, CGA, CYP19A1
18	estradiol benzoate32	9.2	CYP19A1, GNRH1, PRL, CGA
19	metoclopramide32 9 9	11.2	GH1, GNRH1, CGA, PRL
20	cabergoline32 9 9	11.2	GH1, GNRH1, CGA, PRL
21	17-hydroxyprogesterone32 18	10.2	CYP19A1, CGA, GNRH1, PRL
22	flutamide32 9 9	11.2	PRL, CYP19A1, CGA, GNRH1
23	raloxifene32 9 9	11.1	GNRH1, CYP19A1, GNRHR, GH1
24	naloxone32 34 9 9	12.1	PRL, GH1, GNRH1, CGA
25	opiate32	9.1	GNRH1, GH1, PRL, CGA
26	progestin32	9.1	GNRH1, CYP19A1, PRL, CGA
27	mifepristone32 42 9 9	12.0	CYP19A1, GNRH1, CGA, PRL
28	metformin32 34 9 9	12.0	CYP19A1, CGA, GNRH1, GH1
29	estrone32 9 18 9	11.9	PRL, CYP19A1, GH1, GNRH1
30	buserelin32 9 9	10.9	CGA, GNRH1, PRL, CYP19A1, GNRHR
31	alanine32	8.9	GNRHR, FSHR, KISS1R, CGA
32	bromocriptine32 9 9	10.9	GH1, PRL, CGA, GNRH1, GNRHR
33	testosterone32 9 18 9	11.8	GNRHR, CGA, FGFR1, GNRH1, PRL
34	thyroxine32 18	9.8	PRL, GH1, GNRH1, CGA
35	clomiphene citrate32	8.7	CGA, PRL, GNRH1, GH1, CYP19A1
36	dehydroepiandrosterone sulfate32	8.7	GH1, CGA, GNRH1, CYP19A1, PRL
37	leuprolide acetate32	8.4	GNRH1, GH1, GNRHR, PRL, CYP19A1, CGA
38	dihydrotestosterone32 9 18 9	11.4	GH1, GNRH1, CGA, PRL, CYP19A1, GNRHR
39	melatonin32 42 9 18 9	12.3	CYP19A1, GH1, FSHR, PRL, GNRHR
40	tamoxifen32 34 9 9	11.3	GNRH1, GNRHR, GH1, PRL, CGA, CYP19A1
41	dopamine32 9 18 9	11.2	CGA, FGFR1, GNRH1, GNRHR, GH1, PRL
42	androstenedione32 18	8.9	GNRH1, GH1, CGA, CYP19A1, PRL, FSHR
43	arginine32	7.9	GH1, CYP19A1, PRL, SOD1, GNRH1, CGA
44	gnrh32	7.8	GNRHR, KISS1R, KAL1, FSHR, HESX1, GH1
45	adenylate32	7.7	GH1, FSHR, GNRHR, GNRH1, CGA, FGFR1
46	estradiol32 9 18 9	10.5	CGA, FSHR, GNRHR, GH1, CYP19A1, PRL
47	ribonucleic acid32	7.5	GNRH1, FGFR1, PRL, GH1, CGA, FSHR
48	progesterone32 42 9 18 9	10.9	GH1, PRL, CGA, FSHR, FGFR1, GNRH1
49	estrogen32	6.9	GH1, GNRHR, GNRH1, FGFR1, FSHR, CGA
50	steroid32	6.6	FSHR, FGFR1, GNRH1, GNRHR, GH1, PRL

Cellular components related to gonadotropin deficiency according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	7.5	CGA, FGFR1, GNRH1, GH1, PROK2, PRL

Biological processes related to gonadotropin deficiency according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of JAK-STAT cascade	GO:046427	9.6	GH1, PRL
2	gonad development	GO:008406	9.1	CGA, FSHR
3	G-protein coupled receptor signaling pathway	GO:007186	8.5	KISS1R, FSHR, GNRHR, PROK2

Molecular functions related to gonadotropin deficiency according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	prolactin receptor binding	GO:005148	9.6	GH1, PRL
2	hormone activity	GO:005179	8.5	CGA, GNRH1, GH1, PRL