MCID: GNR005
MIFTS: 53

Gonorrhea malady

Summaries for Gonorrhea

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Gonorrhea is a sexually transmitted disease. it is most common in young adults. the bacteria that cause gonorrhea can infect the genital tract, mouth, or anus. you can get gonorrhea during vaginal, oral, or anal sex with an infected partner. a pregnant woman can pass it to her baby during childbirth. gonorrhea does not always cause symptoms. in men, gonorrhea can cause pain when urinating and discharge from the penis. if untreated, it can cause problems with the prostate and testicles. in women, the early symptoms of gonorrhea often are mild. later, it can cause bleeding between periods, pain when urinating, and increased discharge from the vagina. if untreated, it can lead to pelvic inflammatory disease, which causes problems with pregnancy and infertility. your health care provider will diagnose gonorrhea with lab tests. treatment is with antibiotics. treating gonorrhea is becoming more difficult because drug-resistant strains are increasing. correct usage of latex condoms greatly reduces, but does not eliminate, the risk of catching or spreading gonorrhea. nih: national institute of allergy and infectious diseases

MalaCards: Gonorrhea, also known as chronic gonococcal infectious disease of upper genitourinary tract, is related to syphilis and urethritis, and has symptoms including vaginal bleeding between periods, increased vaginal discharge and discharge from the penis. An important gene associated with Gonorrhea is MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase). The drugs ciprofloxacin and erythromycin pwdr and the compounds moxalactam and ertapenem have been mentioned in the context of this disorder. Affiliated tissues include eye or, throat and mouth.

Disease Ontology:8 A primary bacterial infectious disease that is a sexually transmitted infection, located in uterus, located in fallopian tube, located in urethra, located in mouth, located in throat, located in eye or located in anus, has material basis in neisseria gonorrhoeae, which is transmitted by contact with the penis, vagina, mouth, or anus or transmitted by congenitally from mother to baby during delivery. the infection has symptom burning sensation during urination, has symptom discharge from the penis, has symptom increased vaginal discharge, or has symptom vaginal bleeding between periods.

CDC:3 Anyone who is sexually active can get gonorrhea.

Wikipedia:63 Gonorrhea (also spelt gonorrhoea or gonorrhœa; colloquially known as the clap) is a common human... more...

Aliases & Classifications for Gonorrhea

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt
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Aliases & Descriptions:

gonorrhea 8 10 44 33 60
chronic gonococcal infectious disease of upper genitourinary tract 8
chronic gonococcal infectious disease of lower genitourinary tract 8


External Ids:

Disease Ontology8 DOID:7551
MeSH34 D006069
ICD9CM27 098
NCIt39 C35730

Related Diseases for Gonorrhea

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Gonorrhea:



Diseases related to gonorrhea

Clinical Features for Gonorrhea

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8Disease Ontology
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Symptoms:

8
  • vaginal bleeding between periods
  • increased vaginal discharge
  • discharge from the penis
  • burning sensation during urination

Drugs & Therapeutics for Gonorrhea

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Gonorrhea

Search CenterWatch for Gonorrhea

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Gonorrhea

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Anatomical Context for Gonorrhea

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Gonorrhea:

32
Testes, Uterus, Eye, Prostate, Heart, Placenta

FMA organs/tissues related to Gonorrhea:

14
Eye or, Throat, Mouth, Urethra, Fallopian tube, Uterus

Animal Models for Gonorrhea or affiliated genes

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Publications for Gonorrhea

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50PubMed
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Articles related to Gonorrhea:

(show top 50)    (show all 512)
idTitleAuthorsYear
1
Conventional Agar-Based Culture Method, and Nucleic Acid Amplification Test (NAAT) of the cppB Gene for Detection of Neisseria gonorrhea in Pregnant Women Endocervical Swab Specimens. (23983999)
2013
2
Bacterial vaginosis, gonorrhea, and chlamydial infection among women attending a sexually transmitted disease clinic: a longitudinal analysis of possible causal links. (22192490)
2012
3
Linear and non-linear associations of gonorrhea diagnosis rates with social determinants of health. (23202676)
2012
4
Cephalosporin-resistant gonorrhea: it's just a matter of time. (22096785)
2011
5
Rates of gonorrhea and Chlamydia in U.S. military personnel deployed to Iraq and Afghanistan (2004-2009). (21702394)
2011
6
Antimicrobial resistant gonorrhea in Atlanta: 1988-2006. (21844728)
2011
7
Epidemiology of syphilis, gonorrhea and chlamydia in Romania, 1980-2009. (21641041)
2011
8
Condom availability program in an inner city public school: effect on the rates of gonorrhea and chlamydia infection. (21856527)
2011
9
High Chlamydia and gonorrhea incidence and reinfection among performers in the adult film industry. (21844714)
2011
10
Modeling gonorrhea and HIV co-interaction. (20869424)
2011
11
Secular trends of gonorrhea in young adults in Israel: three decades of follow-up. (20512517)
2010
12
Pharyngeal gonorrhea: an important reservoir of infection? (19911969)
2009
13
Small reservoirs: jail screening for gonorrhea and Chlamydia in low prevalence areas. (19477809)
2009
14
Decreasing age disparities in syphilis and gonorrhea incidence rates in the United States, 1981--2005. (18362862)
2008
15
Increases in gonorrhea--eight western states, 2000--2005. (17363891)
2007
16
Gonorrhea, syphilis, clinical prostatitis, and the risk of prostate cancer. (17119041)
2006
17
The prevalence of chlamydia, gonorrhea, and trichomonas in sexual partnerships: implications for partner notification and treatment. (15788928)
2005
18
Chlamydia/gonorrhea combo and HR HPV DNA testing in liquid-based pap. (16078250)
2005
19
False-positive gonorrhea test results with a nucleic acid amplification test: the impact of low prevalence on positive predictive value. (14999624)
2004
20
A comparison of the microbiological characteristics of Neisseria gonorrhoeae isolated from male and female patients with gonorrhea. (15211084)
2004
21
Comparison of methods to increase repeat testing in persons treated for gonorrhea and/or chlamydia at public sexually transmitted disease clinics. (15502669)
2004
22
Summaries for patients. Chlamydia infection among patients receiving treatment for gonorrhea in sexually transmitted disease clinics in the United States. (12899604)
2003
23
Testing for gonorrhea. (14614379)
2003
24
Recall of gonorrhea test kits. (12523286)
2002
25
Comparison of Neisseria gonorrhoeae isolates from the genital tract and pharynx of two gonorrhea patients. (11810580)
2001
26
Clinical aspects of diagnosis of gonorrhea and Chlamydia infection in an acute care setting. (11181134)
2001
27
Patterns of chlamydia and gonorrhea infection in sexual networks in Manitoba, Canada. (11196040)
2001
28
Screening and treatment of sexually transmitted diseases. Part 1: Chlamydia, gonorrhea, and bacterial vaginosis. (11141826)
2000
29
InTray GC medium versus modified Thayer-Martin agar plates for diagnosis of gonorrhea from endocervical specimens. (11015410)
2000
30
Gonorrhea incidence and HIV testing and counseling among adolescents and young adults seen at a clinic for sexually transmitted diseases. (10371179)
1999
31
Gonorrhea in the United States, 1981-1996. Demographic and geographic trends. (9713920)
1998
32
Comparative trial of azithromycin and ciprofloxacin in the treatment of gonorrhea. (9269606)
1997
33
The role of sexual partnership networks in the epidemiology of gonorrhea. (9018783)
1997
34
Signs and symptoms of prevalent and incident cases of gonorrhea and genital chlamydial infection among female prostitutes in Kinshasa, Zaire. (8852966)
1996
35
The falling accuracy of microscopy in the diagnosis of gonorrhea--a cause for concern? (7744413)
1995
36
The management of prepubertal children with gonorrhea. (7586907)
1995
37
Oral treatment of gonorrhea and chlamydia. (8068998)
1994
38
The use of nonoxynol-9 for protection against cervical gonorrhea. (8203685)
1994
39
Single dose azithromycin treatment of gonorrhea and infections caused by C. trachomatis and U. urealyticum in men. (8140488)
1994
40
Multicenter trial of single-dose azithromycin vs. ceftriaxone in the treatment of uncomplicated gonorrhea. Azithromycin Gonorrhea Study Group. (9071422)
1994
41
Vaginal discharge as an indicator of gonorrhea and Chlamydia infection in girls under 12 years old. (8302699)
1993
42
Gross hematuria as a presenting symptom of disseminated gonorrhea. (1603383)
1992
43
Gonorrhea in women prostitutes: clinical data and auxotypes, serovars, plasmid contents of PPNG, and susceptibility profiles. (1902990)
1991
44
Diverging gonorrhea and syphilis trends in the 1980s: are they real? (1928523)
1991
45
Randomized comparison of cefotaxime and ceftriaxone in patients with uncomplicated gonorrhea. (1799912)
1991
46
Isolation of Neisseria gonorrheae and concomitant bacterial microflora from urine obtained by suprapubic bladder puncture in women with gonococcal urethritis. (2113043)
1990
47
Chlamydial conjunctivitis and genital gonorrhea in pregnancy. (2310326)
1990
48
Trends in gonorrhea in homosexually active men--King County, Washington, 1989. (2509885)
1989
49
Molecular epidemiology of gonorrhea. (2497963)
1989
50
Gonorrhea complicating pregnancy and its relation to ophthalmia neonatorum. (18878572)
1948

Genetic Variations for Gonorrhea

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Expression for genes affiliated with Gonorrhea

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gonorrhea

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Pathways for genes affiliated with Gonorrhea

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Compounds for genes affiliated with Gonorrhea

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44Novoseek, 11DrugBank, 49PharmGKB
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Compounds related to Gonorrhea according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1moxalactam4410.3VDAC1, LACTB
2ertapenem4410.3VDAC1, LACTB
3aztreonam4410.3VDAC1, LACTB
4cefoxitin4410.3VDAC1, LACTB
5tazobactam4410.3VDAC1, LACTB
6meropenem4410.3VDAC1, LACTB
7cephalosporin4410.3VDAC1, LACTB
8arcitumomab44 1111.3CEACAM3, CEACAM1
9cefepime44 1111.3LACTB, VDAC1
10imipenem4410.3VDAC1, LACTB
11beta-lactam4410.3VDAC1, LACTB
12ceftazidime44 1111.2LACTB, VDAC1
13cefotaxime44 1111.2VDAC1, LACTB
14aminoglycosides4410.2VDAC1, LACTB
15ampicillin44 1111.2LACTB, VDAC1
16ferricyanide4410.1VDAC1, MTRR
17ceftriaxone44 1111.1VDAC1, LACTB
18amoxicillin44 49 1112.1VDAC1, LACTB
19metronidazole44 1110.9CEACAM3, LACTB
20penicillin449.9LACTB, VDAC1
21sialic acid449.5CD46, CEACAM1, CEACAM3
22phosphatidylinositol449.3CEACAM1, CD46, VDAC1, MTMR12, WARS
23alanine449.3WARS, MTRR, VDAC1, CD46, CEACAM1, CEACAM3

GO Terms for genes affiliated with Gonorrhea

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16Gene Ontology
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Biological processes related to Gonorrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of complement activationGO:03044910.2CD46, C4BPA

Products for genes affiliated with Gonorrhea

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gonorrhea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet