MCID: GNR005
MIFTS: 59

Gonorrhea malady

Infectious diseases, Reproductive diseases, Oral diseases categories
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Summaries for Gonorrhea

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Sources:
8Disease Ontology, 34MedlinePlus, 4CDC, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Gonorrhea is a sexually transmitted disease. it is most common in young adults. the bacteria that cause gonorrhea can infect the genital tract, mouth, or anus. you can get gonorrhea during vaginal, oral, or anal sex with an infected partner. a pregnant woman can pass it to her baby during childbirth. gonorrhea does not always cause symptoms. in men, gonorrhea can cause pain when urinating and discharge from the penis. if untreated, it can cause problems with the prostate and testicles. in women, the early symptoms of gonorrhea often are mild. later, it can cause bleeding between periods, pain when urinating, and increased discharge from the vagina. if untreated, it can lead to pelvic inflammatory disease, which causes problems with pregnancy and infertility. your health care provider will diagnose gonorrhea with lab tests. treatment is with antibiotics. treating gonorrhea is becoming more difficult because drug-resistant strains are increasing. correct usage of latex condoms greatly reduces, but does not eliminate, the risk of catching or spreading gonorrhea. nih: national institute of allergy and infectious diseases

MalaCards: Gonorrhea, also known as chronic gonococcal infectious disease of upper genitourinary tract, is related to syphilis and urethritis, and has symptoms including vaginal bleeding between periods, increased vaginal discharge and discharge from the penis. An important gene associated with Gonorrhea is C4BPA (complement component 4 binding protein, alpha), and among its related pathways are Complement and coagulation cascades and Complement Pathway. The drugs ciprofloxacin and enoxacin and the compounds ferricyanide and tazobactam have been mentioned in the context of this disorder. Affiliated tissues include eye or, throat and urethra.

Disease Ontology:8 A primary bacterial infectious disease that is a sexually transmitted infection, located in uterus, located in fallopian tube, located in urethra, located in mouth, located in throat, located in eye or located in anus, has material basis in neisseria gonorrhoeae, which is transmitted by contact with the penis, vagina, mouth, or anus or transmitted by congenitally from mother to baby during delivery. the infection has symptom burning sensation during urination, has symptom discharge from the penis, has symptom increased vaginal discharge, or has symptom vaginal bleeding between periods.

CDC:4 Anyone who is sexually active can get gonorrhea.

Wikipedia:65 Gonorrhea (also spelled gonorrhoea or gonorrh?a; colloquially known as the clap) is a common human... more...

Aliases & Classifications for Gonorrhea

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8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Reproductive diseases, Oral diseases


Aliases & Descriptions:

gonorrhea 8 10 45 34 62
chronic gonococcal infectious disease of upper genitourinary tract 8
chronic gonococcal infectious disease of lower genitourinary tract 8


External Ids:

Disease Ontology8 DOID:7551
ICD9CM27 098
NCIt40 C35730
MeSH35 D006069

Related Diseases for Gonorrhea

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Gonorrhea:



Diseases related to gonorrhea

Symptoms for Gonorrhea

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8Disease Ontology
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Symptoms:

8
  • vaginal bleeding between periods
  • increased vaginal discharge
  • discharge from the penis
  • burning sensation during urination

Drugs & Therapeutics for Gonorrhea

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Gonorrhea

Search NIH Clinical Center for Gonorrhea

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Gonorrhea

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Anatomical Context for Gonorrhea

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33MalaCards, 14FMA
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MalaCards organs/tissues related to Gonorrhea:

33
Testes, Eye, Uterus, Prostate, Heart, Placenta

FMA organs/tissues related to Gonorrhea:

14
Eye or, Throat, Urethra, Fallopian tube, Uterus, Mouth

Animal Models for Gonorrhea or affiliated genes

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Publications for Gonorrhea

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52PubMed
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Articles related to Gonorrhea:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
Chlamydia and gonorrhea diagnosis, treatment, personnel cost savings, and service delivery improvements after the implementation of express sexually transmitted disease testing in maricopa county, Arizona. (24326585)
2014
2
Gonorrhea positivity in New Orleans public high schools, 1996 to 2005. (23965779)
2013
3
Get Tested Why Not? A novel approach to internet-based chlamydia and gonorrhea testing in Canada. (23823883)
2013
4
A retrospective comparative study of 2-drug oral and intramuscular cephalosporin treatment regimens for pharyngeal gonorrhea. (23408680)
2013
5
Diagnosis and treatment of chlamydia, gonorrhea, and trichomonas in adolescents. (23379401)
2013
6
HIV, rectal chlamydia, and rectal gonorrhea in men who have sex with men attending a sexually transmitted disease clinic in a midwestern US city. (23677015)
2013
7
Rates of asymptomatic nonurethral gonorrhea and chlamydia in a population of university men who have sex with men. (22857141)
2012
8
Sentinel surveillance for pharyngeal chlamydia and gonorrhea among men who have sex with men--San Francisco, 2010. (22592836)
2012
9
A randomized, controlled trial of inSPOT and patient-delivered partner therapy for gonorrhea and chlamydial infection among men who have sex with men. (21934569)
2011
10
Cephalosporin-resistant gonorrhea: it's just a matter of time. (22096785)
2011
11
Patterns of chlamydia/gonorrhea positivity among voluntarily screened New York City public high school students. (21856516)
2011
12
Vaccines for gonorrhea: can we rise to the challenge? (21687431)
2011
13
Rates of gonorrhea and Chlamydia in U.S. military personnel deployed to Iraq and Afghanistan (2004-2009). (21702394)
2011
14
Socioeconomic gradients in sexually transmitted diseases: a geographic information system-based analysis of poverty, race/ethnicity, and gonorrhea rates in California, 2004-2006. (20395580)
2010
15
Culture of non-genital sites increases the detection of gonorrhea in women. (20434928)
2010
16
Mind the gap: the role of time between sex with two consecutive partners on the transmission dynamics of gonorrhea. (18446084)
2008
17
Young women's perspective of the pros and cons to seeking screening for chlamydia and gonorrhea: an exploratory study. (18656072)
2008
18
Social capital and rates of gonorrhea and syphilis in the United States: spatial regression analyses of state-level associations. (17400352)
2007
19
Correlates of acceptance of a hypothetical gonorrhea vaccine by incarcerated women. (17551416)
2007
20
Increases in gonorrhea--eight western states, 2000--2005. (17363891)
2007
21
Prevalence and incidence of pharyngeal gonorrhea in a longitudinal sample of men who have sex with men: the EXPLORE study. (17051493)
2006
22
False-positive gonorrhea test results with a nucleic acid amplification test: the impact of low prevalence on positive predictive value. (14999624)
2004
23
Correlates of engaging in unprotected sex while experiencing dysuria or discharge: a study of men with confirmed gonorrhea. (15215697)
2004
24
Chlamydia and gonorrhea screening in asymptomatic young women. (15125902)
2004
25
Rescreening for gonorrhea and chlamydial infection through the mail: a randomized trial. (14743074)
2004
26
Incidence determinants of gonorrhea, chlamydial genital infection, syphilis and chancroid in attendees at a sexually transmitted disease clinic in Athens, Greece. (14636203)
2003
27
Summaries for patients. Chlamydia infection among patients receiving treatment for gonorrhea in sexually transmitted disease clinics in the United States. (12899604)
2003
28
Spatial bridges for the importation of gonorrhea and chlamydial infection. (14520171)
2003
29
Initial and repeated screening for gonorrhea during pregnancy. (12972798)
2003
30
Clinical management of chlamydia and gonorrhea infection in a county teaching emergency department--concerns in overtreatment, undertreatment, and follow-up treatment success. (12865101)
2003
31
Recall of gonorrhea test kits. (12523286)
2002
32
Gonorrhea surveillance: the missing links. (12466724)
2002
33
Chlamydia, gonorrhea, and HIV-1 prevalence among five populations of women in the Czech and Slovak Republics. (11403195)
2001
34
Sexually transmitted diseases in women. Gonorrhea and syphilis. (10689416)
2000
35
High HIV seroprevalence associated with gonorrhea: New York City Department of Health, sexually transmitted disease clinics, 1990-1997. (10708290)
2000
36
Disease surveillance in the ED: factors leading to the underreporting of gonorrhea. (9517687)
1998
37
American Academy of Pediatrics. Committee on Child Abuse and Neglect. Gonorrhea in prepubertal children. (11345976)
1998
38
Gonorrhea among drug users: an Alaskan versus a national sample. (9643466)
1998
39
Index of suspicion. Case 2. Diagnosis: gonorrhea conjunctivitis. (9114719)
1997
40
Fluoroquinolone treatment failure in gonorrhea. Emergence of a Neisseria gonorrhoeae strain with enhanced resistance to fluoroquinolones. (9153731)
1997
41
Dose-ranging study of CP-99,219 (trovafloxacin) for treatment of uncomplicated gonorrhea. (8807070)
1996
42
Syphilis and gonorrhea. (8641527)
1996
43
Crack cocaine and the exchange of sex for money or drugs. Risk factors for gonorrhea among black adolescents in San Francisco. (1561589)
1992
44
Isolation of Neisseria gonorrheae and concomitant bacterial microflora from urine obtained by suprapubic bladder puncture in women with gonococcal urethritis. (2113043)
1990
45
Gonorrhea. (2123279)
1990
46
Sexually transmitted diseases and native Americans: trends in reported gonorrhea and syphilis morbidity, 1984-88. (2511589)
1989
47
Gonorrhea presenting as a subcutaneous abscess. (2592927)
1989
48
Pharyngeal gonorrhea screening in adolescents: is it necessary? (2780123)
1989
49
Antibiotics--how to use them in 1977-1978: Primary syphilis. Gonorrhea. Nongonococcal urethritis. Gonococcal dermatitis-arthritis syndrome. (628627)
1978
50
Balanitis xerotica obliterans associated with chronic gonorrhea. (20279613)
1946

Variations for Gonorrhea

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Expression for genes affiliated with Gonorrhea

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gonorrhea

Search GEO for disease gene expression data for Gonorrhea.

Pathways for genes affiliated with Gonorrhea

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50PathCards, 30KEGG, 38NCBI BioSystems Database, 53QIAGEN, 60Thomson Reuters, 55Reactome, 57SinoBiological
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Pathways related to Gonorrhea according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Complement Activation, Classical Pathway38
Complement and Coagulation Cascades38
9.9C4BPA, CD46
2
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.9C4BPA, CD46
39.3ANXA4, PRL

Compounds for genes affiliated with Gonorrhea

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45Novoseek, 11DrugBank, 51PharmGKB, 29IUPHAR, 24HMDB
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Compounds related to Gonorrhea according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1ferricyanide4510.0MTRR, VDAC1
2tazobactam459.8LACTB, VDAC1
3moxalactam459.8VDAC1, LACTB
4ertapenem459.8VDAC1, LACTB
5aztreonam459.8VDAC1, LACTB
6cefoxitin459.8VDAC1, LACTB
7cephalosporin459.8VDAC1, LACTB
8meropenem459.8VDAC1, LACTB
9cefepime45 1110.8LACTB, VDAC1
10beta-lactam459.8VDAC1, LACTB
11imipenem459.8VDAC1, LACTB
12ceftazidime45 1110.7VDAC1, LACTB
13cefotaxime45 1110.7LACTB, VDAC1
14aminoglycosides459.7LACTB, VDAC1
15ampicillin45 1110.7LACTB, VDAC1
16ceftriaxone45 1110.7VDAC1, LACTB
17fluoxetine45 51 29 1112.7PRL, VDAC1
18amoxicillin45 51 1111.7VDAC1, LACTB
19l-tryptophan51 29 45 24 1113.6PRL, WARS
20penicillin459.6VDAC1, LACTB
21ciprofloxacin45 51 1111.6LACTB, VDAC1
22cardiolipin45 1110.5C4BPA, VDAC1
23sucrose45 24 1111.2C4BPA, ANXA4, VDAC1
24polysaccharide459.1CD46, CEACAM1, VDAC1
25steroid459.0VDAC1, PRL, CEACAM1, EXTL3
26methionine459.0VDAC1, ANXA4, MTRR
27alanine458.8CD46, MTRR, CEACAM1, WARS, VDAC1
28serine458.4C4BPA, CD46, MTRR, WARS, LACTB, VDAC1
29phosphatidylinositol458.2VDAC1, WARS, ANXA4, CEACAM1, CD46

GO Terms for genes affiliated with Gonorrhea

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16Gene Ontology
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Cellular components related to Gonorrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700627.4CD46, CEACAM1, ANXA4, WARS, ATAD2, VDAC1

Biological processes related to Gonorrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of complement activationGO:0304499.8C4BPA, CD46
2complement activation, classical pathwayGO:0069589.6C4BPA, CD46
3epithelial cell differentiationGO:0308559.2ANXA4, VDAC1

Products for genes affiliated with Gonorrhea

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gonorrhea

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet