MCID: GNR005
MIFTS: 60

Gonorrhea malady

Infectious diseases, Oral diseases, Reproductive diseases categories
Download this MalaCard

Summaries for Gonorrhea

About this section


Fully expand this MalaCard
MedlinePlus:33 Gonorrhea is a sexually transmitted disease. it is most common in young adults. the bacteria that cause gonorrhea can infect the genital tract, mouth, or anus. you can get gonorrhea during vaginal, oral, or anal sex with an infected partner. a pregnant woman can pass it to her baby during childbirth. gonorrhea does not always cause symptoms. in men, gonorrhea can cause pain when urinating and discharge from the penis. if untreated, it can cause problems with the prostate and testicles. in women, the early symptoms of gonorrhea often are mild. later, it can cause bleeding between periods, pain when urinating, and increased discharge from the vagina. if untreated, it can lead to pelvic inflammatory disease, which causes problems with pregnancy and infertility. your health care provider will diagnose gonorrhea with lab tests. treatment is with antibiotics. treating gonorrhea is becoming more difficult because drug-resistant strains are increasing. correct usage of latex condoms greatly reduces, but does not eliminate, the risk of catching or spreading gonorrhea. nih: national institute of allergy and infectious diseases

MalaCards based summary: Gonorrhea, also known as chronic gonococcal infectious disease of upper genitourinary tract, is related to syphilis and pharyngitis, and has symptoms including An important gene associated with Gonorrhea is C4BPA (complement component 4 binding protein, alpha), and among its related pathways are Complement and coagulation cascades and Complement Pathway. The drugs ciprofloxacin and erythromycin pwdr and the compounds ferricyanide and tazobactam have been mentioned in the context of this disorder. Affiliated tissues include uterus, fallopian tube and urethra.

Disease Ontology:8 A primary bacterial infectious disease that is a sexually transmitted infection, located in uterus, located in fallopian tube, located in urethra, located in mouth, located in throat, located in eye or located in anus, has material basis in neisseria gonorrhoeae, which is transmitted by contact with the penis, vagina, mouth, or anus or transmitted by congenitally from mother to baby during delivery. the infection has symptom burning sensation during urination, has symptom discharge from the penis, has symptom increased vaginal discharge, or has symptom vaginal bleeding between periods.

CDC:3 Anyone who is sexually active can get gonorrhea.

Wikipedia:65 Gonorrhea (also spelled gonorrhoea or gonorrh?a; colloquially known as the clap) is a common human... more...

Aliases & Classifications for Gonorrhea

About this section

Gonorrhea, Aliases & Descriptions:

Name: Gonorrhea 8 10 44 33 62
Chronic Gonococcal Infectious Disease of Upper Genitourinary Tract 8
 
Chronic Gonococcal Infectious Disease of Lower Genitourinary Tract 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases
Anatomical: Oral diseases, Reproductive diseases


External Ids:

Disease Ontology8 DOID:7551
ICD9CM27 098
NCIt39 C35730
MeSH34 D006069

Related Diseases for Gonorrhea

About this section

Graphical network of the top 20 diseases related to Gonorrhea:



Diseases related to gonorrhea

Symptoms for Gonorrhea

About this section

Drugs & Therapeutics for Gonorrhea

About this section

Drug clinical trials:

Search ClinicalTrials for Gonorrhea

Search NIH Clinical Center for Gonorrhea

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Gonorrhea

About this section

Anatomical Context for Gonorrhea

About this section

MalaCards organs/tissues related to Gonorrhea:

32
Testes, Eye, Uterus, Prostate, Heart, Placenta

FMA organs/tissues related to Gonorrhea:

14
Uterus, Fallopian tube, Urethra, Mouth, Throat, Eye or

Animal Models for Gonorrhea or affiliated genes

About this section

Publications for Gonorrhea

About this section

Articles related to Gonorrhea:

(show top 50)    (show all 526)
idTitleAuthorsYear
1
Partner meeting place is significantly associated with gonorrhea and chlamydia in adolescents participating in a large high school sexually transmitted disease screening program. (25211256)
2014
2
Chlamydia and gonorrhea diagnosis, treatment, personnel cost savings, and service delivery improvements after the implementation of express sexually transmitted disease testing in maricopa county, Arizona. (24326585)
2014
3
Lupus flare: an uncommon presentation of disseminated gonorrhea. (25024709)
2014
4
An Approach to Unravel Cellular Mechanisms Responsible for Enhanced Neisseria Gonorrhea Induced HIV Acquisition and its Effect on Microbicides. (25357669)
2014
5
Gonorrhea positivity in New Orleans public high schools, 1996 to 2005. (23965779)
2013
6
Get Tested Why Not? A novel approach to internet-based chlamydia and gonorrhea testing in Canada. (23823883)
2013
7
A retrospective comparative study of 2-drug oral and intramuscular cephalosporin treatment regimens for pharyngeal gonorrhea. (23408680)
2013
8
Diagnosis and treatment of chlamydia, gonorrhea, and trichomonas in adolescents. (23379401)
2013
9
HIV, rectal chlamydia, and rectal gonorrhea in men who have sex with men attending a sexually transmitted disease clinic in a midwestern US city. (23677015)
2013
10
Rates of asymptomatic nonurethral gonorrhea and chlamydia in a population of university men who have sex with men. (22857141)
2012
11
Sentinel surveillance for pharyngeal chlamydia and gonorrhea among men who have sex with men--San Francisco, 2010. (22592836)
2012
12
A randomized, controlled trial of inSPOT and patient-delivered partner therapy for gonorrhea and chlamydial infection among men who have sex with men. (21934569)
2011
13
Cephalosporin-resistant gonorrhea: it's just a matter of time. (22096785)
2011
14
Patterns of chlamydia/gonorrhea positivity among voluntarily screened New York City public high school students. (21856516)
2011
15
Vaccines for gonorrhea: can we rise to the challenge? (21687431)
2011
16
Socioeconomic gradients in sexually transmitted diseases: a geographic information system-based analysis of poverty, race/ethnicity, and gonorrhea rates in California, 2004-2006. (20395580)
2010
17
Culture of non-genital sites increases the detection of gonorrhea in women. (20434928)
2010
18
Mind the gap: the role of time between sex with two consecutive partners on the transmission dynamics of gonorrhea. (18446084)
2008
19
Young women's perspective of the pros and cons to seeking screening for chlamydia and gonorrhea: an exploratory study. (18656072)
2008
20
Social capital and rates of gonorrhea and syphilis in the United States: spatial regression analyses of state-level associations. (17400352)
2007
21
Correlates of acceptance of a hypothetical gonorrhea vaccine by incarcerated women. (17551416)
2007
22
Increases in gonorrhea--eight western states, 2000--2005. (17363891)
2007
23
Prevalence and incidence of pharyngeal gonorrhea in a longitudinal sample of men who have sex with men: the EXPLORE study. (17051493)
2006
24
False-positive gonorrhea test results with a nucleic acid amplification test: the impact of low prevalence on positive predictive value. (14999624)
2004
25
Correlates of engaging in unprotected sex while experiencing dysuria or discharge: a study of men with confirmed gonorrhea. (15215697)
2004
26
Chlamydia and gonorrhea screening in asymptomatic young women. (15125902)
2004
27
Rescreening for gonorrhea and chlamydial infection through the mail: a randomized trial. (14743074)
2004
28
Incidence determinants of gonorrhea, chlamydial genital infection, syphilis and chancroid in attendees at a sexually transmitted disease clinic in Athens, Greece. (14636203)
2003
29
Fluoroquinolones, gonorrhea, and the CDC STD treatment guidelines. (12782957)
2003
30
Summaries for patients. Chlamydia infection among patients receiving treatment for gonorrhea in sexually transmitted disease clinics in the United States. (12899604)
2003
31
Spatial bridges for the importation of gonorrhea and chlamydial infection. (14520171)
2003
32
Recall of gonorrhea test kits. (12523286)
2002
33
Gonorrhea surveillance: the missing links. (12466724)
2002
34
Chlamydia, gonorrhea, and HIV-1 prevalence among five populations of women in the Czech and Slovak Republics. (11403195)
2001
35
Sexually transmitted diseases in women. Gonorrhea and syphilis. (10689416)
2000
36
High HIV seroprevalence associated with gonorrhea: New York City Department of Health, sexually transmitted disease clinics, 1990-1997. (10708290)
2000
37
Disease surveillance in the ED: factors leading to the underreporting of gonorrhea. (9517687)
1998
38
American Academy of Pediatrics. Committee on Child Abuse and Neglect. Gonorrhea in prepubertal children. (11345976)
1998
39
Gonorrhea among drug users: an Alaskan versus a national sample. (9643466)
1998
40
Index of suspicion. Case 2. Diagnosis: gonorrhea conjunctivitis. (9114719)
1997
41
Fluoroquinolone treatment failure in gonorrhea. Emergence of a Neisseria gonorrhoeae strain with enhanced resistance to fluoroquinolones. (9153731)
1997
42
Dose-ranging study of CP-99,219 (trovafloxacin) for treatment of uncomplicated gonorrhea. (8807070)
1996
43
Syphilis and gonorrhea. (8641527)
1996
44
Crack cocaine and the exchange of sex for money or drugs. Risk factors for gonorrhea among black adolescents in San Francisco. (1561589)
1992
45
Isolation of Neisseria gonorrheae and concomitant bacterial microflora from urine obtained by suprapubic bladder puncture in women with gonococcal urethritis. (2113043)
1990
46
Sexually transmitted diseases and native Americans: trends in reported gonorrhea and syphilis morbidity, 1984-88. (2511589)
1989
47
Gonorrhea presenting as a subcutaneous abscess. (2592927)
1989
48
Pharyngeal gonorrhea screening in adolescents: is it necessary? (2780123)
1989
49
Antibiotics--how to use them in 1977-1978: Primary syphilis. Gonorrhea. Nongonococcal urethritis. Gonococcal dermatitis-arthritis syndrome. (628627)
1978
50
Balanitis xerotica obliterans associated with chronic gonorrhea. (20279613)
1946

Variations for Gonorrhea

About this section

Expression for genes affiliated with Gonorrhea

About this section
Expression patterns in normal tissues for genes affiliated with Gonorrhea

Search GEO for disease gene expression data for Gonorrhea.

Pathways for genes affiliated with Gonorrhea

About this section

Pathways related to Gonorrhea according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Complement Activation, Classical Pathway37
Complement and Coagulation Cascades37
9.9C4BPA, CD46
2
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.9C4BPA, CD46
39.3ANXA4, PRL

Compounds for genes affiliated with Gonorrhea

About this section
Sources:
44Novoseek, 11DrugBank, 50PharmGKB, 28IUPHAR, 24HMDB
See all sources

Compounds related to Gonorrhea according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1ferricyanide4410.0MTRR, VDAC1
2tazobactam449.8LACTB, VDAC1
3moxalactam449.8VDAC1, LACTB
4ertapenem449.8VDAC1, LACTB
5aztreonam449.8VDAC1, LACTB
6cefoxitin449.8VDAC1, LACTB
7cephalosporin449.8VDAC1, LACTB
8meropenem449.8VDAC1, LACTB
9cefepime44 1110.8LACTB, VDAC1
10beta-lactam449.8VDAC1, LACTB
11imipenem449.8VDAC1, LACTB
12ceftazidime44 1110.7VDAC1, LACTB
13cefotaxime44 1110.7LACTB, VDAC1
14aminoglycosides449.7LACTB, VDAC1
15ampicillin44 1110.7LACTB, VDAC1
16ceftriaxone44 1110.7VDAC1, LACTB
17fluoxetine44 50 28 1112.7PRL, VDAC1
18amoxicillin44 50 1111.7VDAC1, LACTB
19l-tryptophan50 28 44 24 1113.6PRL, WARS
20penicillin449.6VDAC1, LACTB
21ciprofloxacin44 50 1111.6LACTB, VDAC1
22cardiolipin44 1110.5C4BPA, VDAC1
23sucrose44 24 1111.2C4BPA, ANXA4, VDAC1
24polysaccharide449.1CD46, CEACAM1, VDAC1
25steroid449.0VDAC1, PRL, CEACAM1, EXTL3
26methionine449.0VDAC1, ANXA4, MTRR
27alanine448.8CD46, MTRR, CEACAM1, WARS, VDAC1
28serine448.4C4BPA, CD46, MTRR, WARS, LACTB, VDAC1
29phosphatidylinositol448.2VDAC1, WARS, ANXA4, CEACAM1, CD46

GO Terms for genes affiliated with Gonorrhea

About this section

Cellular components related to Gonorrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular vesicular exosomeGO:0700627.4CD46, CEACAM1, ANXA4, WARS, ATAD2, VDAC1

Biological processes related to Gonorrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of complement activationGO:0304499.8C4BPA, CD46
2complement activation, classical pathwayGO:0069589.6C4BPA, CD46
3epithelial cell differentiationGO:0308559.2ANXA4, VDAC1

Products for genes affiliated with Gonorrhea

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Gonorrhea

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet