MCID: GNR005
MIFTS: 53

Gonorrhea malady

Summaries for Gonorrhea

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Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Gonorrhea is a sexually transmitted disease. it is most common in young adults. the bacteria that cause gonorrhea can infect the genital tract, mouth, or anus. you can get gonorrhea during vaginal, oral, or anal sex with an infected partner. a pregnant woman can pass it to her baby during childbirth. gonorrhea does not always cause symptoms. in men, gonorrhea can cause pain when urinating and discharge from the penis. if untreated, it can cause problems with the prostate and testicles. in women, the early symptoms of gonorrhea often are mild. later, it can cause bleeding between periods, pain when urinating, and increased discharge from the vagina. if untreated, it can lead to pelvic inflammatory disease, which causes problems with pregnancy and infertility. your health care provider will diagnose gonorrhea with lab tests. treatment is with antibiotics. treating gonorrhea is becoming more difficult because drug-resistant strains are increasing. correct usage of latex condoms greatly reduces, but does not eliminate, the risk of catching or spreading gonorrhea. nih: national institute of allergy and infectious diseases

MalaCards: Gonorrhea, also known as chronic gonococcal infectious disease of upper genitourinary tract, is related to syphilis and urethritis, and has symptoms including vaginal bleeding between periods, increased vaginal discharge and discharge from the penis. An important gene associated with Gonorrhea is MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase). The drugs ciprofloxacin and erythromycin pwdr and the compounds moxalactam and ertapenem have been mentioned in the context of this disorder. Affiliated tissues include eye or, throat and urethra.

Disease Ontology:8 A primary bacterial infectious disease that is a sexually transmitted infection, located in uterus, located in fallopian tube, located in urethra, located in mouth, located in throat, located in eye or located in anus, has material basis in neisseria gonorrhoeae, which is transmitted by contact with the penis, vagina, mouth, or anus or transmitted by congenitally from mother to baby during delivery. the infection has symptom burning sensation during urination, has symptom discharge from the penis, has symptom increased vaginal discharge, or has symptom vaginal bleeding between periods.

CDC:3 Anyone who is sexually active can get gonorrhea.

Wikipedia:63 Gonorrhea (also spelt gonorrhoea or gonorrhœa; colloquially known as the clap) is a common human... more...

Aliases & Classifications for Gonorrhea

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt
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Aliases & Descriptions:

gonorrhea 8 10 44 33 60
chronic gonococcal infectious disease of upper genitourinary tract 8
chronic gonococcal infectious disease of lower genitourinary tract 8


External Ids:

Disease Ontology8 DOID:7551
MeSH34 D006069
ICD9CM27 098
NCIt39 C35730

Related Diseases for Gonorrhea

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Gonorrhea:



Diseases related to gonorrhea

Clinical Features for Gonorrhea

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8Disease Ontology
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Symptoms:

8
  • vaginal bleeding between periods
  • increased vaginal discharge
  • discharge from the penis
  • burning sensation during urination

Drugs & Therapeutics for Gonorrhea

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Gonorrhea

Drug clinical trials:

Search ClinicalTrials for Gonorrhea

Search NIH Clinical Center for Gonorrhea

Search CenterWatch for Gonorrhea

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Gonorrhea

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Anatomical Context for Gonorrhea

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Gonorrhea:

32
Testes, Eye, Uterus, Prostate, Heart, Placenta

FMA organs/tissues related to Gonorrhea:

14
Eye or, Throat, Urethra, Uterus, Mouth, Fallopian tube

Animal Models for Gonorrhea or affiliated genes

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Publications for Gonorrhea

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50PubMed
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Articles related to Gonorrhea:

(show top 50)    (show all 512)
idTitleAuthorsYear
1
First Three Neisseria gonorrhoeae Isolates with High-Level Resistance to Azithromycin in Sweden: a Threat to Currently Available Dual-Antimicrobial Regimens for Treatment of Gonorrhea? (24189248)
2014
2
Diagnosis and treatment of chlamydia, gonorrhea, and trichomonas in adolescents. (23379401)
2013
3
Cost-effectiveness of screening men in Maricopa County jails for chlamydia and gonorrhea to avert infections in women. (24275727)
2013
4
Update on Chlamydia and gonorrhea screening during pregnancy. (23594327)
2013
5
Predictors of high chlamydia and gonorrhea positivity rates among men in the southern United States. (22708244)
2012
6
Racial residential segregation and rates of gonorrhea in the United States, 2003-2007. (22594733)
2012
7
Changes in fluoroquinolone use for gonorrhea following publication of revised treatment guidelines. (22095341)
2012
8
Pelvic inflammatory disease (PID) from Chlamydia trachomatis versus PID from Neisseria gonorrhea: from clinical suspicion to therapy. (23007248)
2012
9
Chlamydia and gonorrhea screening using urine-based nucleic acid amplification testing among males entering New York City jails: a pilot study. (22419642)
2012
10
In vitro activity of ertapenem versus ceftriaxone against Neisseria gonorrhoeae isolates with highly diverse ceftriaxone MIC values and effects of ceftriaxone resistance determinants: ertapenem for treatment of gonorrhea? (22547617)
2012
11
Patterns of chlamydia/gonorrhea positivity among voluntarily screened New York City public high school students. (21856516)
2011
12
CDC update on gonorrhea: expand treatment to limit resistance. (22163356)
2011
13
Emergency physicians' patterns of treatment for presumed gonorrhea and chlamydia in women: one center's practice. (18242922)
2009
14
EPT Permitted: TMB Changes Rules to Fight Chlamydia, Gonorrhea. (19957240)
2009
15
Using spatial regression methods to examine the association between county-level racial/ethnic composition and reported cases of Chlamydia and gonorrhea: an illustration with data from the state of Texas. (19734821)
2009
16
Decreasing age disparities in syphilis and gonorrhea incidence rates in the United States, 1981--2005. (18362861)
2008
17
Partner notification for gonorrhea-time for new ideas. (17414067)
2007
18
Gonorrhea and Chlamydia in emergency departments: screening, diagnosis, and treatment. (17324351)
2007
19
Prevalence and incidence of pharyngeal gonorrhea in a longitudinal sample of men who have sex with men: the EXPLORE study. (17051493)
2006
20
Co-occurrence of chancroid and gonorrhea. (17241572)
2006
21
Expedited partner therapy for adolescents diagnosed with gonorrhea or chlamydia: a review and commentary. (17030286)
2006
22
Incidence determinants of gonorrhea, chlamydial genital infection, syphilis and chancroid in attendees at a sexually transmitted disease clinic in Athens, Greece. (14636203)
2003
23
Spatial bridges for the importation of gonorrhea and chlamydial infection. (14520171)
2003
24
Partner notification for HIV and STD in the United States: low coverage for gonorrhea, chlamydial infection, and HIV. (12782949)
2003
25
Prevalence and factors associated with gonorrhea and chlamydial infection in at-risk females presenting to an urban emergency department. (12671555)
2003
26
Increasing incidence of gonorrhea in Israel associated with countrywide dissemination of a ciprofloxacin-resistant strain. (12072921)
2002
27
Ciprofloxacin for the treatment of uncomplicated gonorrhea infection in adolescents: does the benefit outweigh the risk? (12353206)
2002
28
Prevalence, incidence, and correlates of chlamydia and gonorrhea among young adult injection drug users. (11547626)
2001
29
Is there a seasonal variation in gonorrhea and chlamydia in adolescents? (11358703)
2001
30
Gonorrhea among men who have sex with men: outbreak caused by a single genotype of erythromycin-resistant Neisseria gonorrhoeae with a single-base pair deletion in the mtrR promoter region. (10837198)
2000
31
Gonorrhea, chlamydia and the sexual network: pushing the envelope. (10782744)
2000
32
Assessment of a geographically targeted field intervention on gonorrhea incidence in two New York State counties. (10333285)
1999
33
Reduced chlamydial infection and gonorrhea among commercial sex workers in Fukuoka City, Japan. (9781437)
1998
34
A sustainable behavioral intervention to increase condom use and reduce gonorrhea among sex workers in Singapore: 2-year follow-up. (9922072)
1998
35
Historical, physical, and laboratory characteristics of female ED patients with positive chlamydia and gonorrhea cultures. (8639221)
1996
36
A tale of two sexually transmitted diseases. Prevalences and predictors of chlamydia and gonorrhea in women attending Colorado family planning clinics. (8946633)
1996
37
The sensitivity of 173 Sydney isolates of Neisseria gonorrhoeae to cefpodoxime and other antibiotics used to treat gonorrhea. (7603756)
1995
38
Gonorrhea rates among US men, adjusted for sexual activity. (8092391)
1994
39
Gonorrhea and chlamydial infections. ACOG Technical Bulletin Number 190-March 1994 (replaces No. 89, November 1985). (7915691)
1994
40
Single-dose ciprofloxacin for the treatment of uncomplicated gonorrhea: a worldwide summary. (7871449)
1994
41
Prevalence of human immunodeficiency virus in the patient population of a sexually transmitted disease clinic. Association with syphilis and gonorrhea. (1595013)
1992
42
Gonorrhea and chlamydial infection: comparison of contact tracing performed by physicians or by a specialized service. (2049705)
1991
43
A gonorrhea model treating sensitive and resistant strains in a multigroup population. (2134495)
1990
44
Gonorrhea: diagnostic and therapeutic strategies in the era of resistance to antibiotics. (2117965)
1990
45
Pharyngeal gonorrhea screening in adolescents: is it necessary? (2780123)
1989
46
Evaluation of a prototype DNA probe test for the noncultural diagnosis of gonorrhea. (2498388)
1989
47
Gonorrhea and salpingitis among American teenagers, 1960-1981. (6656834)
1983
48
Gonorrhea and acute epididymitis. (118394)
1979
49
Gonorrhea: recommended treatment schedules--1974. Part I: Uncomplicated gonococcal infections in men and women; uncomplicated gonorrhea in pregnant patients; and acute salpingitis. (123639)
1975
50
Anorectal gonorrhea presenting as ulcerative proctitis. (4196651)
1973

Genetic Variations for Gonorrhea

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Expression for genes affiliated with Gonorrhea

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gonorrhea

Search GEO for disease gene expression data for Gonorrhea.

Pathways for genes affiliated with Gonorrhea

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Compounds for genes affiliated with Gonorrhea

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44Novoseek, 11DrugBank, 49PharmGKB
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Compounds related to Gonorrhea according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1moxalactam4410.3VDAC1, LACTB
2ertapenem4410.3VDAC1, LACTB
3aztreonam4410.3VDAC1, LACTB
4cefoxitin4410.3VDAC1, LACTB
5tazobactam4410.3VDAC1, LACTB
6meropenem4410.3VDAC1, LACTB
7cephalosporin4410.3VDAC1, LACTB
8arcitumomab44 1111.3CEACAM3, CEACAM1
9cefepime44 1111.3LACTB, VDAC1
10imipenem4410.3VDAC1, LACTB
11beta-lactam4410.3VDAC1, LACTB
12ceftazidime44 1111.2LACTB, VDAC1
13cefotaxime44 1111.2VDAC1, LACTB
14aminoglycosides4410.2VDAC1, LACTB
15ampicillin44 1111.2LACTB, VDAC1
16ferricyanide4410.1VDAC1, MTRR
17ceftriaxone44 1111.1VDAC1, LACTB
18amoxicillin44 49 1112.1VDAC1, LACTB
19metronidazole44 1110.9CEACAM3, LACTB
20penicillin449.9LACTB, VDAC1
21sialic acid449.5CD46, CEACAM1, CEACAM3
22phosphatidylinositol449.3CEACAM1, CD46, VDAC1, MTMR12, WARS
23alanine449.3WARS, MTRR, VDAC1, CD46, CEACAM1, CEACAM3

GO Terms for genes affiliated with Gonorrhea

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16Gene Ontology
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Biological processes related to Gonorrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of complement activationGO:03044910.2CD46, C4BPA

Products for genes affiliated with Gonorrhea

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gonorrhea

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet