MCID: GNR005
MIFTS: 52

Gonorrhea malady

Summaries for Gonorrhea

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Gonorrhea is a sexually transmitted disease. it is most common in young adults. the bacteria that cause gonorrhea can infect the genital tract, mouth, or anus. you can get gonorrhea during vaginal, oral, or anal sex with an infected partner. a pregnant woman can pass it to her baby during childbirth. gonorrhea does not always cause symptoms. in men, gonorrhea can cause pain when urinating and discharge from the penis. if untreated, it can cause problems with the prostate and testicles. in women, the early symptoms of gonorrhea often are mild. later, it can cause bleeding between periods, pain when urinating, and increased discharge from the vagina. if untreated, it can lead to pelvic inflammatory disease, which causes problems with pregnancy and infertility. your health care provider will diagnose gonorrhea with lab tests. treatment is with antibiotics. treating gonorrhea is becoming more difficult because drug-resistant strains are increasing. correct usage of latex condoms greatly reduces, but does not eliminate, the risk of catching or spreading gonorrhea. nih: national institute of allergy and infectious diseases

MalaCards: Gonorrhea, also known as chronic gonococcal infectious disease of upper genitourinary tract, is related to syphilis and urethritis, and has symptoms including burning sensation during urination, discharge from the penis and increased vaginal discharge. An important gene associated with Gonorrhea is MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase). The drugs ciprofloxacin and enoxacin and the compounds moxalactam and ertapenem have been mentioned in the context of this disorder. Affiliated tissues include fallopian tube, mouth and uterus.

Disease Ontology:8 A primary bacterial infectious disease that is a sexually transmitted infection, located in uterus, located in fallopian tube, located in urethra, located in mouth, located in throat, located in eye or located in anus, has material basis in neisseria gonorrhoeae, which is transmitted by contact with the penis, vagina, mouth, or anus or transmitted by congenitally from mother to baby during delivery. the infection has symptom burning sensation during urination, has symptom discharge from the penis, has symptom increased vaginal discharge, or has symptom vaginal bleeding between periods.

CDC:3 Anyone who is sexually active can get gonorrhea.

Wikipedia:64 Gonorrhea (colloquially known as the clap) is a common human sexually transmitted infection caused by... more...

Aliases & Classifications for Gonorrhea

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt
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Aliases & Descriptions:

gonorrhea 8 10 45 34 61
chronic gonococcal infectious disease of upper genitourinary tract 8
chronic gonococcal infectious disease of lower genitourinary tract 8


External Ids:

Disease Ontology8 DOID:7551
MeSH35 D006069
ICD9CM27 098
NCIt40 C35730

Related Diseases for Gonorrhea

Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Gonorrhea:



Diseases related to gonorrhea

Clinical Features for Gonorrhea

Sources:
8Disease Ontology
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Symptoms:

8 (see all 4)
  • burning sensation during urination
  • discharge from the penis
  • increased vaginal discharge
  • vaginal bleeding between periods

Drugs & Therapeutics for Gonorrhea

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gonorrhea

Drug clinical trials:

Search ClinicalTrials for Gonorrhea

Search NIH Clinical Center for Gonorrhea

Search CenterWatch for Gonorrhea

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Gonorrhea

Anatomical Context for Gonorrhea

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Gonorrhea:

33
Uterus, Heart, Placenta, Prostate

FMA organs/tissues related to Gonorrhea:

14
Fallopian tube, Mouth, Uterus, Urethra, Throat, Eye or

Animal Models for Gonorrhea or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Gonorrhea

Sources:
51PubMed
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Articles related to Gonorrhea:

(show top 50)    (show all 529)
idTitleAuthorsYear
1
Limits of the lab: diagnosing "latent gonorrhea," 1872-1910. (23603529)
2013
2
Gonorrhea as a moving target: how do we sharpen our aim and strengthen our arrows? (23470069)
2013
3
Comparing swabs for diagnosing chlamydia and gonorrhea in women: recent findings. (24236734)
2013
4
Neisseria gonorrhea and Chlamydia trachomatis screening at intrauterine device insertion and pelvic inflammatory disease. (23168755)
2012
5
Prevalence and correlates of rectal Chlamydia and gonorrhea among female clients at sexually transmitted disease clinics. (23191945)
2012
6
Chlamydia and gonorrhea in South Carolina: an ecologic perspective. (23210390)
2012
7
A randomized, controlled trial of inSPOT and patient-delivered partner therapy for gonorrhea and chlamydial infection among men who have sex with men. (21934569)
2011
8
Vaccines for gonorrhea: can we rise to the challenge? (21687431)
2011
9
Epidemiology of syphilis, gonorrhea and chlamydia in Romania, 1980-2009. (21641041)
2011
10
Is Neisseria gonorrhoeae initiating a future era of untreatable gonorrhea?: detailed characterization of the first strain with high-level resistance to ceftriaxone. (21576437)
2011
11
Association of Trichomonas infection with gonorrhea or Chlamydia. (20117902)
2011
12
Sentinel surveillance of rectal chlamydia and gonorrhea among males--San Francisco, 2005-2008. (20118677)
2010
13
Clinical inquiries. Should you test or treat partners of patients with gonorrhea, chlamydia, or trichomoniasis? (20074503)
2010
14
Pharyngeal gonorrhea: an important reservoir of infection? (19911969)
2009
15
Evidence against the "booty pack": Trichomonas not associated with gonorrhea or Chlamydia. (18024062)
2009
16
Using spatial regression methods to examine the association between county-level racial/ethnic composition and reported cases of Chlamydia and gonorrhea: an illustration with data from the state of Texas. (19734821)
2009
17
Repeat infection with Chlamydia and gonorrhea among females: a systematic review of the literature. (19617871)
2009
18
Missed opportunities for early detection of chlamydia and gonorrhea in school-based health centers. (16773033)
2006
19
Gonorrhea: update. (16448912)
2006
20
Impact of sexual networks on risk for gonorrhea and chlamydia among low-income urban African American adolescents. (15812456)
2005
21
Factors that influence the cost effectiveness of gonorrhea screening in emergency departments. (15976601)
2005
22
Injectable use may increase women's odds of getting chlamydia or gonorrhea. (15997501)
2005
23
Prevalence and risk factors of chlamydia and gonorrhea among rural Nepali women. (15923297)
2005
24
Epidemiology of chlamydial infection, gonorrhea, and trichomoniasis in the United States--2005. (15963872)
2005
25
A cost-effectiveness analysis of interventions to increase repeat testing in patients treated for gonorrhea or chlamydia at public sexually transmitted disease clinics. (16118602)
2005
26
Vicious and virtuous circles in the dynamics of infectious disease and the provision of health care: gonorrhea in Britain as an example. (16088832)
2005
27
Chlamydia and gonorrhea co-occurrence in a high school population. (15215698)
2004
28
Clinical management of chlamydia and gonorrhea infection in a county teaching emergency department--concerns in overtreatment, undertreatment, and follow-up treatment success. (12865101)
2003
29
Testing for genital gonorrhea infections in prepubertal girls with suspected sexual abuse. (12867837)
2003
30
Special NIH review confirms condoms effective against transmission of HIV, gonorrhea. (11697100)
2001
31
Evaluation of chlamydia and gonorrhea screening criteria: San Francisco sexually transmitted disease clinic: 1997 to 1998. (10726651)
2000
32
Sexually transmitted disease clinic clients at risk for subsequent gonorrhea and chlamydia infections: possible 'core' transmitters. (10907910)
2000
33
American Academy of Pediatrics. Committee on Child Abuse and Neglect. Gonorrhea in prepubertal children. (11345976)
1998
34
Gonorrhea in the United States, 1981-1996. Demographic and geographic trends. (9713920)
1998
35
Dose-ranging study of CP-99,219 (trovafloxacin) for treatment of uncomplicated gonorrhea. (8807070)
1996
36
Syphilis and gonorrhea. (8641527)
1996
37
Use of wet mount to predict Chlamydia trachomatis and Neisseria gonorrhea cervicitis in primary care. (8884256)
1996
38
Ciprofloxacin for gonorrhea--250 mg or 500 mg? (8919746)
1996
39
Historical, physical, and laboratory characteristics of female ED patients with positive chlamydia and gonorrhea cultures. (8639221)
1996
40
The core group revisited: the effect of partner mixing and migration on the spread of gonorrhea, Chlamydia, and HIV. (8155907)
1994
41
Effectiveness of repeated gonorrhea cultures in the third trimester. (18475322)
1993
42
Multicenter trial of fleroxacin versus ceftriaxone in the treatment of uncomplicated gonorrhea. (8452187)
1993
43
Predictors of chlamydial infection and gonorrhea among patients seen by private practitioners. (1900212)
1991
44
Trends in gonorrhea in Canadians 15-24 years of age, 1981-1988. (2611920)
1989
45
The incremental cost of screening, diagnosis, and treatment of gonorrhea and chlamydia in a family planning clinic. (2500721)
1989
46
Local immune response in gonorrheal cervicitis. (3106171)
1986
47
Clinical trial of cycloserine in donovanosis, lymphogranuloma venereum, and gonorrhea. (13355260)
1955-1956
48
WEEKLY clinicopathological exercises: Walthard's rests on salpinx; salpingitis, old, gonorrheal. (14806782)
1951
49
Balanitis xerotica obliterans associated with chronic gonorrhea. (20279613)
1946
50
Vasotomy in the Treatment of Chronic Seminal Vesiculitis of Gonorrheal Origin. (21773205)
1936

Genetic Variations for Gonorrhea

Expression for genes affiliated with Gonorrhea

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gonorrhea

Search GEO for disease gene expression data for Gonorrhea.

Pathways for genes affiliated with Gonorrhea

Compounds for genes affiliated with Gonorrhea

Sources:
45Novoseek, 11DrugBank, 50PharmGKB
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Compounds related to Gonorrhea according to GeneCards/GeneDecks:

(show all 23)
idCompoundScoreTop Affiliating Genes
1moxalactam4510.3VDAC1, LACTB
2ertapenem4510.3VDAC1, LACTB
3aztreonam4510.3VDAC1, LACTB
4cefoxitin4510.3VDAC1, LACTB
5tazobactam4510.3VDAC1, LACTB
6meropenem4510.3VDAC1, LACTB
7cephalosporin4510.3VDAC1, LACTB
8arcitumomab45 1111.3CEACAM3, CEACAM1
9cefepime45 1111.3LACTB, VDAC1
10imipenem4510.3VDAC1, LACTB
11beta-lactam4510.3VDAC1, LACTB
12ceftazidime45 1111.2LACTB, VDAC1
13cefotaxime45 1111.2VDAC1, LACTB
14aminoglycosides4510.2VDAC1, LACTB
15ampicillin45 1111.2LACTB, VDAC1
16ferricyanide4510.1VDAC1, MTRR
17ceftriaxone45 1111.1VDAC1, LACTB
18amoxicillin45 50 1112.1VDAC1, LACTB
19metronidazole45 1110.9CEACAM3, LACTB
20penicillin459.9LACTB, VDAC1
21sialic acid459.5CD46, CEACAM1, CEACAM3
22phosphatidylinositol459.3CEACAM1, CD46, VDAC1, MTMR12, WARS
23alanine459.3WARS, MTRR, VDAC1, CD46, CEACAM1, CEACAM3

GO Terms for genes affiliated with Gonorrhea

Sources:
16Gene Ontology
See all sources

Biological processes related to Gonorrhea according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of complement activationGO:03044910.2CD46, C4BPA

Products for genes affiliated with Gonorrhea

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gonorrhea

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet