MCID: GDP001
MIFTS: 57

Goodpasture Syndrome malady

Nephrological diseases, Respiratory diseases, Immune diseases categories

Summaries for Goodpasture Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Goodpasture syndrome is an autoimmune disease of unknown cause that affects the lungs and kidneys. the typical symptoms of goodpasture syndrome include pulmonary alveolar hemorrhage (bleeding in the lungs), glomerulonephritis, and the presence of anti-glomerular basement membranes (anti-gbm) antibodies in the blood. last updated: 9/17/2008

MalaCards: Goodpasture Syndrome, also known as anti-glomerular basement membrane disease, is related to glomerulonephritis and membranous glomerulonephritis, and has symptoms including retinal detachment, lung/pulmonary/alveolar hemorrhage/hematoma and vascularitis/vasculitides/arteritis. An important gene associated with Goodpasture Syndrome is COL4A3 (collagen, type IV, alpha 3 (Goodpasture antigen)), and among its related pathways are Non-integrin membrane-ECM interactions and Focal Adhesion. The compounds arresten and hypothiocyanite have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and kidney, and related mouse phenotypes are other and muscle.

Disease Ontology:8 An autoimmune disease that is characterized by glomerulonephritis located in kidney and hemorrhaging located in lung.

Wikipedia:63 Goodpasture syndrome (GPS; also known as Goodpasture’s disease, anti-glomerular basement antibody... more...

Description from OMIM:46 233450

Aliases & Classifications for Goodpasture Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 46OMIM, 60UMLS, 34MeSH, 56SNOMED-CT, 27ICD9CM, 39NCIt, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

48
goodpasture syndrome:
Inheritance: Sporadic; Age of onset: Adolescence / Young adulthood


Aliases & Descriptions:

goodpasture syndrome 8 42 10 44 48
anti-glomerular basement membrane disease 8 48 46 60
rapidly progressive glomerulonephritis with pulmonary hemorrhage 42
anti-glomerular basement membrane antibody disease 42
glomerulonephritis - pulmonary hemorrhage 42
pulmonary renal syndrome 42
anti-gbm syndrome 48


External Ids:

Disease Ontology8 DOID:9808
MeSH34 D019867
OMIM46 233450
ICD9CM27 446.21
NCIt39 C34649
SNOMED-CT via Orphanet57 50581000, 236506009
ICD10 via Orphanet26 M31.0+, N08.5*

Related Diseases for Goodpasture Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Goodpasture Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 50)
idRelated DiseaseScoreTop Affiliating Genes
1glomerulonephritis29.9COL4A5, COL4A3, NID1, MPO, CD79A
2membranous glomerulonephritis10.6
3thrombotic thrombocytopenic purpura10.5
4dermatomyositis10.4
5psoriasis10.4
6iga glomerulonephritis10.3
7kidney disease10.3
8pneumonia10.3
9vasculitis10.1
10crescentic glomerulonephritis10.0
11wegener's granulomatosis10.0
12rapidly progressive glomerulonephritis10.0
13immune-complex glomerulonephritis10.0
14alpha chain disease10.0
15end stage renal failure10.0
16churg-strauss syndrome10.0
17adenocarcinoma10.0
18collagen disease10.0
19influenza10.0
20lung adenocarcinoma10.0
21purpura10.0
22respiratory failure10.0
23proliferative glomerulonephritis10.0CD79A
24pulmonary systemic sclerosis10.0
25atopic dermatitis10.0
26giant hemangioma10.0
27cavernous hemangioma10.0
28dermatitis10.0
29eosinophilia10.0
30hemangioma10.0
31hemorrhagic fever with renal syndrome10.0
32hypertension10.0
33malignant hypertension10.0
34pulmonary eosinophilia10.0
35renal hypertension10.0
36autoimmune hemolytic anemia10.0CD79A
37brucellosis10.0CD79A
38leiomyomatosis10.0COL4A5
39hypersensitivity vasculitis10.0CD79A, MPO
40immunoglobulin a vasculitis10.0CD79A, MPO
41thin basement membrane nephropathy10.0COL4A5, COL4A3
42peripheral vascular disease10.0CD79A, MPO
43plasmacytoma10.0CD79A
44autosomal recessive alport syndrome10.0COL4A5, COL4A3
45alport syndrome10.0COL4A3, COL4A5
46bronchiectasis10.0CD79A, MPO
47focal segmental glomerulosclerosis10.0CD79A, COL4A5
48primary hyperoxaluria10.0COL4A5, MPO, CD79A
49proteinuria10.0COL4A5, COL4A3, MPO, CD79A
50nephritis10.0COL4A5, COL4A3, NID1, MPO, CD79A

Graphical network of the top 20 diseases related to Goodpasture Syndrome:



Diseases related to goodpasture syndrome

Clinical Features for Goodpasture Syndrome

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Sources:
46OMIM, 48Orphanet
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Clinical features from OMIM:

233450

Clinical synopsis from OMIM:

233450

Symptoms:

48 (show all 19)
  • retinal detachment
  • lung/pulmonary/alveolar hemorrhage/hematoma
  • vascularitis/vasculitides/arteritis
  • hemoptysis
  • renal glomerular defect/glomerulopathy
  • purpura/petichiae
  • hematuria/microhematuria
  • arthritis/synovitis/synovial proliferation
  • proteinuria
  • renal failure
  • fever/chilling
  • articular/joint pain/arthralgia
  • anaemia
  • thoracic/chest pain
  • cough
  • myalgia/muscular pain
  • autoimmunity/autoimmune reaction/autoantibodies
  • lung/pulmonary infiltrates
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction

Drugs & Therapeutics for Goodpasture Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Goodpasture Syndrome

Drug clinical trials:

Search ClinicalTrials for Goodpasture Syndrome

Search NIH Clinical Center for Goodpasture Syndrome

Search CenterWatch for Goodpasture Syndrome

Genetic Tests for Goodpasture Syndrome

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Anatomical Context for Goodpasture Syndrome

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Goodpasture Syndrome:

32
Kidney, Lung, T cells, Monocytes, Bone marrow, Bone

FMA organs/tissues related to Goodpasture Syndrome:

14
Kidney, Lung

Animal Models for Goodpasture Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Goodpasture Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053959.0NID1, COL4A3, COL4A1
2MP:00053698.6MPO, NID1, COL4A1, COL4A3BP
3MP:00053677.8COL4A5, COL4A1, COL4A3, CD79A
4MP:00053857.4MPO, NID1, COL4A3, COL4A1, COL4A3BP, COL4A5
5MP:00053767.2COL4A5, COL4A3BP, COL4A1, COL4A3, MPO, CD79A

Publications for Goodpasture Syndrome

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Sources:
50PubMed
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Articles related to Goodpasture Syndrome:

(show top 50)    (show all 55)
idTitleAuthorsYear
1
Cellular and molecular aspects of Goodpasture syndrome. (22218111)
2012
2
Reversible posterior leukoencephalopathy syndrome in Goodpasture syndrome. (22806294)
2012
3
Extracorporeal membrane oxygenation as a platform for recovery: a case report of a child with pulmonary hemorrhage, refractory hypoxemic respiratory failure, and new onset goodpasture syndrome. (22893987)
2012
4
Reversible posterior leukoencephalopathy in the course of Goodpasture syndrome. (22251235)
2012
5
A case of Goodpasture syndrome positive for anti-GBM antibody and MPO-ANCA complicated by a variety of serious infections. (21426895)
2011
6
Epidemiology and etiology of wegener granulomatosis, microscopic polyangiitis, churg-strauss syndrome and goodpasture syndrome: vasculitides with frequent lung involvement. (21674413)
2011
7
Plasma exchange for Goodpasture syndrome. (20117054)
2010
8
Goodpasture's 1919 article on the etiology of influenza-the historical road to what we now call Goodpasture Syndrome. (19680022)
2009
9
Migratory pulmonary infiltrates. Goodpasture syndrome. (19124794)
2009
10
Patient with antibody-negative relapse of Goodpasture syndrome. (17474560)
2007
11
Anti-glomerular basement membrane antibodies in the diagnosis of Goodpasture syndrome: a comparison of different assays. (16234289)
2006
12
Zebrafish to humans: evolution of the alpha3-chain of type IV collagen and emergence of the autoimmune epitopes associated with Goodpasture syndrome. (16254142)
2006
13
Goodpasture syndrome in a pregnant woman. (16260570)
2005
14
Goodpasture syndrome. (16183752)
2005
15
Pathogenesis of Goodpasture syndrome: a molecular perspective. (14631560)
2003
16
Goodpasture syndrome during the course of a SchAPnlein-Henoch purpura. (11979333)
2002
17
Goodpasture syndrome: pathophysiology, diagnosis, and management. (12143452)
2001
18
Renal fibroblast-like cells in Goodpasture syndrome rats. (11473642)
2001
19
Genetically modified bone marrow continuously supplies anti-inflammatory cells and suppresses renal injury in mouse Goodpasture syndrome. (11418463)
2001
20
Goodpasture syndrome. (15912919)
2000
21
Inhibition of monocyte chemoattractant protein-1 expression in tubular epithelium attenuates tubulointerstitial alteration in rat Goodpasture syndrome. (10720946)
2000
22
Goodpasture syndrome. (10027952)
1999
23
Complete recovery of renal function in a dialysis-dependent patient with Goodpasture syndrome. (9509464)
1998
24
Goodpasture syndrome and end-stage renal failure--to transplant or not to transplant? (9641155)
1998
25
Goodpasture syndrome involving overlap with Wegener's granulomatosis and anti-glomerular basement membrane disease. (9355084)
1997
26
Susceptibility to anti-glomerular basement membrane disease and Goodpasture syndrome is linked to MHC class II genes and the emergence of T cell-mediated immunity in mice. (9410904)
1997
27
Specificity of circulating and tissue-bound autoantibodies in Goodpasture syndrome. (8705733)
1996
28
Anti-alpha1(IV) collagen autoantibodies associated with lung adenocarcinoma presenting as the Goodpasture syndrome. (8607593)
1996
29
Goodpasture syndrome: selective removal of anti-alpha 3 (IV) collagen autoantibodies. A potential therapeutic alternative to plasmapheresis. (8864724)
1996
30
Identification of the alpha 3 chain of type IV collagen as the common autoantigen in antibasement membrane disease and Goodpasture syndrome. (8589284)
1995
31
The alpha 3 chain of type IV collagen induces autoimmune Goodpasture syndrome. (8016138)
1994
32
Anti-type IV collagen antibodies in Goodpasture syndrome. (8004967)
1994
33
Goodpasture syndrome: molecular and clinical advances. (8041241)
1994
34
Type IV collagen: structure, gene organization, and role in human diseases. Molecular basis of Goodpasture and Alport syndromes and diffuse leiomyomatosis. (8253711)
1993
35
Provocation of pulmonary haemorrhage in Goodpasture syndrome by chlorine gas. (8384347)
1993
36
Pregnancy complicated by Goodpasture syndrome. (1565371)
1992
37
Isolated pulmonary Goodpasture syndrome. (1946080)
1991
38
Goodpasture syndrome. Localization of the epitope for the autoantibodies to the carboxyl-terminal region of the alpha 3(IV) chain of basement membrane collagen. (1721062)
1991
39
Goodpasture syndrome: molecular architecture and function of basement membrane antigen. (2671489)
1989
40
A rapid assay for circulating anti-glomerular basement membrane antibodies in Goodpasture syndrome. (2647855)
1989
41
Isolation of the specific glomerular basement membrane antigen involved in Goodpasture syndrome. (6324201)
1984
42
Immune-complex-mediated glomerulonephritis and pulmonary hemorrhage simulating Goodpasture syndrome. (149843)
1978
43
Goodpasture syndrome treated with immunosuppression and plasma exchange. (879947)
1977
44
Goodpasture syndrome: recovery after severe renal insufficiency. (938176)
1976
45
Treatment of Goodpasture syndrome with cyclophosphamide, prednisone and plasma exchange transfusions. (949874)
1976
46
Goodpasture syndrome with recovery after renal failure. (4406940)
1974
47
Goodpasture syndrome. Dissociation from antibodies to glomerular basement membrane. (4124196)
1973
48
Goodpasture syndrome. (5923420)
1966
49
Idiopathic pulmonary haemosiderosis and the Goodpasture syndrome. (5833618)
1965
50
On the Goodpasture syndrome. Comments on two cases of colagenosis of the lung. (5881737)
1965

Genetic Variations for Goodpasture Syndrome

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Expression for genes affiliated with Goodpasture Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Goodpasture Syndrome

Search GEO for disease gene expression data for Goodpasture Syndrome.

Pathways for genes affiliated with Goodpasture Syndrome

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53Reactome, 29KEGG, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 49PharmGKB
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Pathways related to Goodpasture Syndrome according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1COL4A1, COL4A5
2
Hide members
8.8COL4A5, COL4A1, COL4A3
3
Hide members
8.8COL4A3, COL4A1, COL4A5
4
Hide members
8.8COL4A3, COL4A1, COL4A5
58.8COL4A3, COL4A1, COL4A5
6
Hide members
8.8COL4A3, COL4A1, COL4A5
7
Hide members
8.8COL4A3, COL4A1, COL4A5
88.8COL4A5, COL4A1, COL4A3
9
Cell adhesion Integrin-mediated cell adhesion and migration
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8.8COL4A5, COL4A1, COL4A3
108.8COL4A5, COL4A1, COL4A3
118.8COL4A5, COL4A1, COL4A3
128.8COL4A5, COL4A1, COL4A3
13
Cell adhesion Endothelial cell contacts by non-junctional mechanisms
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8.8COL4A3, COL4A1, COL4A5
148.8COL4A5, COL4A1, COL4A3
15
Hide members
8.8COL4A3, COL4A1, COL4A5
16
Hide members
8.8COL4A5, COL4A1, COL4A3
178.8COL4A3, COL4A1, COL4A5
188.8COL4A3, COL4A1, COL4A5
19
Cell adhesion ECM remodeling
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8.3NID1, COL4A3, COL4A1, COL4A5
20
Hide members
8.1CD79A, COL4A3, COL4A1, COL4A5

Compounds for genes affiliated with Goodpasture Syndrome

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44Novoseek, 24HMDB, 2BitterDB, 49PharmGKB, 11DrugBank, 28IUPHAR
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Compounds related to Goodpasture Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1arresten449.8COL4A3, COL4A1
2hypothiocyanite44 2410.6CD79A, MPO
3thiocyanate44 2410.6CD79A, MPO
4dapsone2 44 49 1112.6CD79A, MPO
5sulfasalazine44 28 49 1112.5MPO, CD79A
6methacholine44 1110.4CD79A, MPO
7carbamazepine44 49 1111.3CD79A, MPO
8vitamin b12449.1MPO, CD79A
9heparin44 28 11 2412.0CD79A, MPO, NID1

GO Terms for genes affiliated with Goodpasture Syndrome

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16Gene Ontology
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Cellular components related to Goodpasture Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basal laminaGO:0056058.9NID1, COL4A5
2endoplasmic reticulum lumenGO:0057888.8COL4A3, COL4A1, COL4A5
3collagen type IVGO:0055878.7COL4A3, COL4A1, COL4A5

Biological processes related to Goodpasture Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glomerular basement membrane developmentGO:0328369.6NID1, COL4A3
2neuromuscular junction developmentGO:0075289.0COL4A5, COL4A1
3collagen catabolic processGO:0305748.9COL4A3, COL4A1, COL4A5
4extracellular matrix disassemblyGO:0226178.8COL4A3, COL4A1, COL4A5
5axon guidanceGO:0074118.8COL4A3, COL4A1, COL4A5
6extracellular matrix organizationGO:0301988.5COL4A3, COL4A1, COL4A5

Molecular functions related to Goodpasture Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituentGO:0052018.8COL4A3, COL4A1, COL4A5

Products for genes affiliated with Goodpasture Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Goodpasture Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet