MCID: GDP001
MIFTS: 51

Goodpasture Syndrome malady

Nephrological, Respiratory, Immune categories

Summaries for Goodpasture Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Goodpasture syndrome is an autoimmune disease of unknown cause that affects the lungs and kidneys. the typical symptoms of goodpasture syndrome include pulmonary alveolar hemorrhage (bleeding in the lungs), glomerulonephritis, and the presence of anti-glomerular basement membranes (anti-gbm) antibodies in the blood. last updated: 9/17/2008

MalaCards: Goodpasture Syndrome, also known as anti-glomerular basement membrane disease, is related to nephritis and good syndrome, and has symptoms including respiratory distress/dyspnea/respiratory failure/lung volume reduction, arthritis/synovitis/synovial proliferation and proteinuria. An important gene associated with Goodpasture Syndrome is COL4A3 (collagen, type IV, alpha 3 (Goodpasture antigen)), and among its related pathways are Non-integrin membrane-ECM interactions and Focal Adhesion. The compounds arresten and hypothiocyanite have been mentioned in the context of this disorder. Affiliated tissues include kidney, lung and kidney, and related mouse phenotypes are other and muscle.

Disease Ontology:8 An autoimmune disease that is characterized by glomerulonephritis located in kidney and hemorrhaging located in lung.

Description from OMIM:47 233450

Aliases & Classifications for Goodpasture Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 47OMIM, 61UMLS, 35MeSH, 57SNOMED-CT, 27ICD9CM, 40NCIt, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Nephrological, Respiratory, Immune


Characteristics (Orphanet epidemiological data):

49
goodpasture syndrome:
Inheritance: Sporadic; Age of onset: Adolescence / Young adulthood


Aliases & Descriptions:

goodpasture syndrome 8 43 10 45 49
anti-glomerular basement membrane disease 8 49 47 61
rapidly progressive glomerulonephritis with pulmonary hemorrhage 43
anti-glomerular basement membrane antibody disease 43
glomerulonephritis - pulmonary hemorrhage 43
pulmonary renal syndrome 43
anti-gbm syndrome 49


External Ids:

Disease Ontology8 DOID:9808
MeSH35 D019867
OMIM47 233450
ICD9CM27 446.21
NCIt40 C34649
ICD10 via Orphanet26 M31.0
SNOMED-CT via Orphanet58 50581000

Related Diseases for Goodpasture Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Goodpasture Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 41)
idRelated DiseaseScoreTop Affiliating Genes
1nephritis30.0NID1, COL4A5, COL4A3, MPO, CD79A
2good syndrome10.9
3anti-basement membrane glomerulonephritis10.6
4membranous glomerulonephritis10.5
5thrombotic thrombocytopenic purpura10.5
6lupus nephritis10.4
7wegener's granulomatosis10.2
8n syndrome10.2
9vasculitis10.1
10crescentic glomerulonephritis10.0
11rapidly progressive glomerulonephritis10.0
12immune-complex glomerulonephritis10.0
13alpha chain disease10.0
14churg-strauss syndrome10.0
15arc syndrome10.0
16adenocarcinoma10.0
17turner syndrome10.0
18micro syndrome10.0
19microscopic polyangiitis10.0
20pulmonary systemic sclerosis10.0
21atopic dermatitis10.0
22giant hemangioma10.0
23cutaneous sclerosis10.0
24hemorrhagic fever10.0
25pulmonary function10.0
26proliferative glomerulonephritis10.0CD79A
27autoimmune hemolytic anemia10.0CD79A
28brucellosis10.0CD79A
29leiomyomatosis10.0COL4A5
30hypersensitivity vasculitis10.0MPO, CD79A
31immunoglobulin a vasculitis10.0MPO, CD79A
32autosomal recessive alport syndrome10.0COL4A5, COL4A3
33peripheral vascular disease10.0CD79A, MPO
34plasmacytoma10.0CD79A
35thin basement membrane nephropathy10.0COL4A5, COL4A3
36alport syndrome10.0COL4A5, COL4A3
37bronchiectasis10.0CD79A, MPO
38focal segmental glomerulosclerosis10.0COL4A5, CD79A
39primary hyperoxaluria10.0COL4A5, CD79A, MPO
40proteinuria10.0CD79A, MPO, COL4A3, COL4A5
41glomerulonephritis10.0CD79A, COL4A5, COL4A3, NID1, MPO

Graphical network of the top 20 diseases related to Goodpasture Syndrome:



Diseases related to goodpasture syndrome

Clinical Features for Goodpasture Syndrome

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

233450

Clinical synopsis from OMIM:

233450

Symptoms:

49 (show all 19)
  • respiratory distress/dyspnea/respiratory failure/lung volume reduction
  • arthritis/synovitis/synovial proliferation
  • proteinuria
  • renal failure
  • fever/chilling
  • articular/joint pain/arthralgia
  • anaemia
  • thoracic/chest pain
  • cough
  • myalgia/muscular pain
  • autoimmunity/autoimmune reaction/autoantibodies
  • lung/pulmonary infiltrates
  • hematuria/microhematuria
  • purpura/petichiae
  • renal glomerular defect/glomerulopathy
  • retinal detachment
  • lung/pulmonary/alveolar hemorrhage/hematoma
  • vascularitis/vasculitides/arteritis
  • hemoptysis

Drugs & Therapeutics for Goodpasture Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Goodpasture Syndrome

Drug clinical trials:

Search ClinicalTrials for Goodpasture Syndrome

Search NIH Clinical Center for Goodpasture Syndrome

Search CenterWatch for Goodpasture Syndrome

Genetic Tests for Goodpasture Syndrome

Anatomical Context for Goodpasture Syndrome

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Goodpasture Syndrome:

33
Kidney, Lung, Bone marrow, Monocytes, T cells

FMA organs/tissues related to Goodpasture Syndrome:

14
Kidney, Lung

Animal Models for Goodpasture Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Goodpasture Syndrome

Sources:
51PubMed
See all sources

Articles related to Goodpasture Syndrome:

(show top 50)    (show all 76)
idTitleAuthorsYear
1
Goodpasture's syndrome associated with thrombotic thrombocytopenic purpura secondary to an ADAMTS-13 deficit. (23111709)
2013
2
Goodpasture's syndrome with concomitant immune complex mixed membranous and proliferative glomerulonephritis. (23320965)
2013
3
Plasma exchange in Goodpasture syndrome associated with Turner's syndrome: A case report. (23515881)
2012
4
Cellular and molecular aspects of Goodpasture syndrome. (22218111)
2012
5
Reversible posterior leukoencephalopathy syndrome in Goodpasture syndrome. (22806294)
2012
6
Extracorporeal membrane oxygenation as a platform for recovery: a case report of a child with pulmonary hemorrhage, refractory hypoxemic respiratory failure, and new onset goodpasture syndrome. (22893987)
2012
7
A case of Goodpasture syndrome positive for anti-GBM antibody and MPO-ANCA complicated by a variety of serious infections. (21426895)
2011
8
Epidemiology and etiology of wegener granulomatosis, microscopic polyangiitis, churg-strauss syndrome and goodpasture syndrome: vasculitides with frequent lung involvement. (21674413)
2011
9
Goodpasture's 1919 article on the etiology of influenza-the historical road to what we now call Goodpasture Syndrome. (19680022)
2009
10
Migratory pulmonary infiltrates. Goodpasture syndrome. (19124794)
2009
11
Patient with antibody-negative relapse of Goodpasture syndrome. (17474560)
2007
12
Anti-glomerular basement membrane antibodies in the diagnosis of Goodpasture syndrome: a comparison of different assays. (16234289)
2006
13
Zebrafish to humans: evolution of the alpha3-chain of type IV collagen and emergence of the autoimmune epitopes associated with Goodpasture syndrome. (16254142)
2006
14
Goodpasture syndrome. (16183752)
2005
15
Waldenstrom's macroglobulinemia presenting as Goodpasture's syndrome. (15526921)
2004
16
Goodpasture syndrome during the course of a SchAPnlein-Henoch purpura. (11979333)
2002
17
Conversion of Goodpasture's syndrome into membranous glomerulonephritis. (11572902)
2001
18
Goodpasture syndrome: pathophysiology, diagnosis, and management. (12143452)
2001
19
Renal fibroblast-like cells in Goodpasture syndrome rats. (11473642)
2001
20
Reactive oxygen species expose cryptic epitopes associated with autoimmune goodpasture syndrome. (10748075)
2000
21
Goodpasture syndrome. (10027952)
1999
22
An 18-year-old man with Goodpasture's syndrome and ANCA-negative central nervous system vasculitis. (9469509)
1998
23
Goodpasture syndrome and end-stage renal failure--to transplant or not to transplant? (9641155)
1998
24
Goodpasture syndrome involving overlap with Wegener's granulomatosis and anti-glomerular basement membrane disease. (9355084)
1997
25
Anti-GBM antibodies in Goodpasture syndrome; anatomy of an epitope. (9140985)
1997
26
A case of Goodpasture's syndrome with myeloperoxidase specific anti-neutrophil cytoplasmic autoantibody (MPO-ANCA) during chronic interstitial pneumonia]. (9567081)
1997
27
Specificity of circulating and tissue-bound autoantibodies in Goodpasture syndrome. (8705733)
1996
28
Anti-alpha1(IV) collagen autoantibodies associated with lung adenocarcinoma presenting as the Goodpasture syndrome. (8607593)
1996
29
Pregnancy in a patient with Goodpasture syndrome and renal transplantation. (8672189)
1996
30
Sera from patients with anti-GBM nephritis including goodpasture syndrome show heterogenous reactivity to recombinant NC1 domain of type IV collagen alpha chains. (8941581)
1996
31
Identification of the alpha 3 chain of type IV collagen as the common autoantigen in antibasement membrane disease and Goodpasture syndrome. (8589284)
1995
32
Anti-type IV collagen antibodies in Goodpasture syndrome. (8004967)
1994
33
Goodpasture syndrome: molecular and clinical advances. (8041241)
1994
34
Provocation of pulmonary haemorrhage in Goodpasture syndrome by chlorine gas. (8384347)
1993
35
A case of Goodpasture's syndrome associated with anti-myeloperoxidase antibodies. (1318119)
1992
36
Pregnancy complicated by Goodpasture syndrome. (1565371)
1992
37
Goodpasture syndrome. Localization of the epitope for the autoantibodies to the carboxyl-terminal region of the alpha 3(IV) chain of basement membrane collagen. (1721062)
1991
38
A case of Goodpasture's syndrome. Myeloperoxidase antibodies as a valuable serological marker in vasculitis]. (2172672)
1990
39
Goodpasture syndrome: molecular architecture and function of basement membrane antigen. (2671489)
1989
40
Isolation of the specific glomerular basement membrane antigen involved in Goodpasture syndrome. (6324201)
1984
41
Immune-complex-mediated glomerulonephritis and pulmonary hemorrhage simulating Goodpasture syndrome. (149843)
1978
42
Simultaneous occurrence of Goodpasture's syndrome and follicular mucinosis. (889344)
1977
43
Goodpasture syndrome treated with immunosuppression and plasma exchange. (879947)
1977
44
Goodpasture syndrome: recovery after severe renal insufficiency. (938176)
1976
45
Treatment of Goodpasture syndrome with cyclophosphamide, prednisone and plasma exchange transfusions. (949874)
1976
46
Goodpasture's syndrome (pulmonary hemosiderosis with nephritis). (130220)
1976
47
Goodpasture syndrome. Dissociation from antibodies to glomerular basement membrane. (4124196)
1973
48
Variant "Goodpasture's syndrome"? The need for immunologic criteria in rapidly progressive glomerulonephritis and hemorrhagic pneumonitis. (4933295)
1971
49
On the Goodpasture syndrome. Comments on two cases of colagenosis of the lung. (5881737)
1965
50
GOODPASTURE'S SYNDROME: PULMONARY HEMOSIDEROSIS WITH GLOMERULONEPHRITIS. (14105018)
1964

Genetic Variations for Goodpasture Syndrome

Expression for genes affiliated with Goodpasture Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Goodpasture Syndrome

Search GEO for disease gene expression data for Goodpasture Syndrome.

Pathways for genes affiliated with Goodpasture Syndrome

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 52QIAGEN, 12EMD Millipore, 50PharmGKB
See all sources

Pathways related to Goodpasture Syndrome according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.1COL4A1, COL4A5
2
Hide members
8.8COL4A5, COL4A1, COL4A3
3
Hide members
8.8COL4A3, COL4A1, COL4A5
4
Hide members
8.8COL4A3, COL4A1, COL4A5
58.8COL4A3, COL4A1, COL4A5
6
Hide members
8.8COL4A3, COL4A1, COL4A5
7
Hide members
8.8COL4A3, COL4A1, COL4A5
88.8COL4A5, COL4A1, COL4A3
9
Cell adhesion Integrin-mediated cell adhesion and migration
Hide members
8.8COL4A5, COL4A1, COL4A3
108.8COL4A5, COL4A1, COL4A3
118.8COL4A5, COL4A1, COL4A3
128.8COL4A5, COL4A1, COL4A3
13
Cell adhesion Endothelial cell contacts by non-junctional mechanisms
Hide members
8.8COL4A3, COL4A1, COL4A5
148.8COL4A5, COL4A1, COL4A3
15
Hide members
8.8COL4A3, COL4A1, COL4A5
16
Hide members
8.8COL4A5, COL4A1, COL4A3
178.8COL4A3, COL4A1, COL4A5
188.8COL4A3, COL4A1, COL4A5
19
Cell adhesion ECM remodeling
Hide members
8.3NID1, COL4A3, COL4A1, COL4A5
20
Hide members
8.1CD79A, COL4A3, COL4A1, COL4A5

Compounds for genes affiliated with Goodpasture Syndrome

Sources:
45Novoseek, 24HMDB, 2BitterDB, 50PharmGKB, 11DrugBank, 29IUPHAR
See all sources

Compounds related to Goodpasture Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1arresten459.8COL4A1, COL4A3
2hypothiocyanite45 2410.6MPO, CD79A
3thiocyanate45 2410.6MPO, CD79A
4dapsone2 45 50 1112.6MPO, CD79A
5sulfasalazine45 29 50 1112.5MPO, CD79A
6methacholine45 1110.4MPO, CD79A
7carbamazepine45 50 1111.3MPO, CD79A
8vitamin b12459.1MPO, CD79A
9heparin45 29 11 2412.0NID1, MPO, CD79A

GO Terms for genes affiliated with Goodpasture Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Goodpasture Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1basal laminaGO:0056058.9NID1, COL4A5
2endoplasmic reticulum lumenGO:0057888.8COL4A3, COL4A1, COL4A5
3collagen type IVGO:0055878.7COL4A3, COL4A1, COL4A5

Biological processes related to Goodpasture Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glomerular basement membrane developmentGO:0328369.6NID1, COL4A3
2neuromuscular junction developmentGO:0075289.0COL4A5, COL4A1
3collagen catabolic processGO:0305748.9COL4A3, COL4A1, COL4A5
4extracellular matrix disassemblyGO:0226178.8COL4A3, COL4A1, COL4A5
5axon guidanceGO:0074118.8COL4A3, COL4A1, COL4A5
6extracellular matrix organizationGO:0301988.5COL4A3, COL4A1, COL4A5

Molecular functions related to Goodpasture Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix structural constituentGO:0052018.8COL4A3, COL4A1, COL4A5

Products for genes affiliated with Goodpasture Syndrome

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Goodpasture Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet