MCID: GDP001
MIFTS: 51

Goodpasture Syndrome malady

Categories: Rare diseases, Cardiovascular diseases, Nephrological diseases, Respiratory diseases, Bone diseases, Immune diseases

Aliases & Classifications for Goodpasture Syndrome

Aliases & Descriptions for Goodpasture Syndrome:

Name: Goodpasture Syndrome 54 12 50 56 52 14
Anti-Glomerular Basement Membrane Disease 12 56 42 69
Pulmonary Renal Syndrome 50 69
Rapidly Progressive Glomerulonephritis with Pulmonary Hemorrhage 50
Anti-Glomerular Basement Membrane Antibody Disease 50
Anti-Basement Membrane Glomerulonephritis 69
Glomerulonephritis - Pulmonary Hemorrhage 50
Anti-Gbm Syndrome 56
Anti-Gbm Disease 52

Characteristics:

Orphanet epidemiological data:

56
anti-glomerular basement membrane disease
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: Adolescent,Adult;

HPO:

32
goodpasture syndrome:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 54 233450
Disease Ontology 12 DOID:9808
ICD10 33 M31.0
ICD9CM 35 446.21
MeSH 42 D019867
Orphanet 56 ORPHA375
UMLS via Orphanet 70 C0403529
ICD10 via Orphanet 34 M31.0+ N08.5*
UMLS 69 C0403529

Summaries for Goodpasture Syndrome

NIH Rare Diseases : 50 goodpasture syndrome is an autoimmune disease that affects the lungs and kidneys and is characterized by pulmonary alveolar hemorrhage (bleeding in the lungs) and a kidney disease known as glomerulonephritis. some use the term "goodpasture syndrome" for the findings of glomerulonephritis and pulmonary hemorrhage and the term "goodpasture disease" for those patients with glomerulonephritis, pulmonary hemorrhage, and anti-gbm antibodies. currently, the preferred term for both conditions is “anti-gbm antibody disease”. circulating antibodies are directed against the collagen of the part of the kidney known as the glomerular basement membrane (gbm), resulting in acute or rapidly progressive glomerulonephritis. antibodies also attack the collagen of the air sacs of the lung (alveoli) resulting in bleeding of the lung (pulmonary hemorrhage). symptoms may include  general body discomfort or pain, bleeding from the nose and/or blood in the urine, respiratory problems, anemia, chest pain, and kidney failure. anti-gbm disease is thought to result from an environmental insult (smoking, infections, exposure to certain drugs) in a person with genetic susceptibility, such as a specific human leukocyte antigen (hla) type.  diagnosis is confirmed with the presence of anti-gbm antibody in the blood or in the kidney. the treatment of choice is plasmapheresis in conjunction with prednisone and cyclophosphamide. last updated: 3/28/2017

MalaCards based summary : Goodpasture Syndrome, also known as anti-glomerular basement membrane disease, is related to rapidly progressive glomerulonephritis and deafness, autosomal recessive 30, and has symptoms including arthralgia, myalgia and fever. An important gene associated with Goodpasture Syndrome is COL4A3 (Collagen Type IV Alpha 3 Chain), and among its related pathways/superpathways are Phospholipase-C Pathway and Degradation of the extracellular matrix. The drugs Metformin and Pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include lung, kidney and bone, and related phenotype is Increased shRNA abundance (Z-score > 2).

Disease Ontology : 12 A hypersensitivity reaction type II disease that is characterized by glomerulonephritis located in kidney and hemorrhaging located in lung.

Wikipedia : 71 Goodpasture syndrome (GPS) is a rare autoimmune disease in which antibodies attack the basement membrane... more...

Description from OMIM: 233450

Related Diseases for Goodpasture Syndrome

Diseases related to Goodpasture Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
id Related Disease Score Top Affiliating Genes
1 rapidly progressive glomerulonephritis 10.9
2 deafness, autosomal recessive 30 10.2 COL4A3 COL4A4
3 spinal canal and spinal cord meningioma 10.1 CD79A COL4A3
4 pediatric meningioma 10.0 CD79A MPO
5 vulvar disease 10.0 CD79A MPO
6 colonic benign neoplasm 10.0 CD79A MPO
7 subacute glomerulonephritis 10.0 CD79A MPO
8 dysentery 10.0 CD79A MPO
9 uveitis 10.0 CD79A MPO
10 cyclotropia 10.0 CD79A MPO
11 chemical colitis 10.0 CD79A MPO
12 dermatomycosis 10.0 CD79A MPO
13 omsk hemorrhagic fever 10.0 CD79A MPO
14 dislocation of ear ossicle 10.0 CD79A MPO
15 metal allergy 10.0 CD79A MPO
16 psoriasis 10.0
17 dermatomyositis 10.0
18 postinflammatory pulmonary fibrosis 10.0 CD79A MPO
19 small intestine lymphoma 10.0 CD79A MPO
20 pancreatic serous cystadenoma 9.9 CD79A MPO
21 rosacea conjunctivitis 9.9 CD79A MPO
22 brca1- and brca2-associated hereditary breast and ovarian cancer 9.9 COL4A3 COL4A4 COL4A5
23 alport syndrome, autosomal dominant 9.9 COL4A3 COL4A4 COL4A5
24 arthrogryposis, distal, type 5d 9.9 COL4A3 COL4A4 COL4A5
25 hematuria, benign familial 9.9 COL4A3 COL4A4 COL4A5
26 immune-complex glomerulonephritis 9.9 CD79A MPO
27 lymph node adenoid cystic carcinoma 9.9 CD79A COL4A3
28 epithelioid neurofibroma 9.9 COL4A3 COL4A4 COL4A5
29 central nervous system origin vertigo 9.9 CD79A MPO
30 filariasis 9.9 CD79A MPO
31 corneal endothelial dystrophy 1, autosomal dominant 9.9 COL4A3 COL4A4
32 cockayne syndrome 9.9 COL4A5 MPO
33 lung giant cell carcinoma 9.9 COL4A3 COL4A4 COL4A5
34 heart valve disease 9.9 CD79A COL4A3 MPO
35 breast apocrine carcinoma in situ 9.9 CD79A MPO
36 familial nephrotic syndrome 9.8 CD79A COL4A5
37 vasculitis 9.7
38 microscopic polyangiitis 9.6
39 encephalopathy 9.6
40 wegener granulomatosis 9.6
41 adult respiratory distress syndrome 9.6
42 end stage renal failure 9.6
43 glomerulonephritis 9.6
44 respiratory failure 9.6
45 adenocarcinoma 9.6
46 churg-strauss syndrome 9.6
47 purpura 9.6
48 influenza 9.6
49 fg syndrome 5 9.5 CD79A COL4A3 COL4A4 COL4A5 NID1
50 eosinophilic fasciitis 8.9 CD79A COL4A3 COL4A3BP COL4A4 COL4A5 MPO

Comorbidity relations with Goodpasture Syndrome via Phenotypic Disease Network (PDN):


Acute Kidney Failure Chronic Kidney Failure
Deficiency Anemia Heart Disease
Respiratory Failure

Graphical network of the top 20 diseases related to Goodpasture Syndrome:



Diseases related to Goodpasture Syndrome

Symptoms & Phenotypes for Goodpasture Syndrome

Symptoms by clinical synopsis from OMIM:

233450

Clinical features from OMIM:

233450

Human phenotypes related to Goodpasture Syndrome:

56 32 (show all 21)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 arthralgia 56 32 Occasional (29-5%) HP:0002829
2 myalgia 56 32 Occasional (29-5%) HP:0003326
3 fever 56 32 Occasional (29-5%) HP:0001945
4 hemoptysis 56 32 Very frequent (99-80%) HP:0002105
5 chest pain 56 32 Very frequent (99-80%) HP:0100749
6 respiratory insufficiency 56 32 Very frequent (99-80%) HP:0002093
7 arthritis 56 32 Occasional (29-5%) HP:0001369
8 renal insufficiency 56 32 Occasional (29-5%) HP:0000083
9 proteinuria 56 32 Very frequent (99-80%) HP:0000093
10 anemia 56 32 Very frequent (99-80%) HP:0001903
11 autoimmunity 56 32 Very frequent (99-80%) HP:0002960
12 glomerulopathy 56 32 Very frequent (99-80%) HP:0100820
13 hematuria 56 32 Frequent (79-30%) HP:0000790
14 retinal detachment 56 32 Occasional (29-5%) HP:0000541
15 purpura 56 32 Occasional (29-5%) HP:0000979
16 cough 56 32 Very frequent (99-80%) HP:0012735
17 vasculitis 56 32 Very frequent (99-80%) HP:0002633
18 pulmonary infiltrates 56 32 Very frequent (99-80%) HP:0002113
19 persistence of primary teeth 56 32 Very frequent (99-80%) HP:0006335
20 dyspnea 32 HP:0002094
21 glomerulonephritis 32 HP:0000099

GenomeRNAi Phenotypes related to Goodpasture Syndrome according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 10.12 MPO
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 10.12 CD79A
3 Increased shRNA abundance (Z-score > 2) GR00366-A-110 10.12 NID1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-123 10.12 COL4A3BP
5 Increased shRNA abundance (Z-score > 2) GR00366-A-125 10.12 RAN
6 Increased shRNA abundance (Z-score > 2) GR00366-A-126 10.12 MPO
7 Increased shRNA abundance (Z-score > 2) GR00366-A-135 10.12 RAN
8 Increased shRNA abundance (Z-score > 2) GR00366-A-146 10.12 RAN
9 Increased shRNA abundance (Z-score > 2) GR00366-A-151 10.12 COL4A3BP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-157 10.12 MPO
11 Increased shRNA abundance (Z-score > 2) GR00366-A-158 10.12 RAN
12 Increased shRNA abundance (Z-score > 2) GR00366-A-159 10.12 RAN
13 Increased shRNA abundance (Z-score > 2) GR00366-A-166 10.12 RAN
14 Increased shRNA abundance (Z-score > 2) GR00366-A-176 10.12 MPO
15 Increased shRNA abundance (Z-score > 2) GR00366-A-177 10.12 NID1 RAN CD79A COL4A3BP
16 Increased shRNA abundance (Z-score > 2) GR00366-A-186 10.12 MPO
17 Increased shRNA abundance (Z-score > 2) GR00366-A-201 10.12 RAN
18 Increased shRNA abundance (Z-score > 2) GR00366-A-22 10.12 RAN
19 Increased shRNA abundance (Z-score > 2) GR00366-A-29 10.12 MPO COL4A3BP
20 Increased shRNA abundance (Z-score > 2) GR00366-A-30 10.12 RAN
21 Increased shRNA abundance (Z-score > 2) GR00366-A-32 10.12 NID1 RAN
22 Increased shRNA abundance (Z-score > 2) GR00366-A-36 10.12 MPO
23 Increased shRNA abundance (Z-score > 2) GR00366-A-49 10.12 NID1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-57 10.12 MPO
25 Increased shRNA abundance (Z-score > 2) GR00366-A-6 10.12 RAN
26 Increased shRNA abundance (Z-score > 2) GR00366-A-63 10.12 CD79A COL4A3BP NID1
27 Increased shRNA abundance (Z-score > 2) GR00366-A-67 10.12 NID1 COL4A3BP
28 Increased shRNA abundance (Z-score > 2) GR00366-A-7 10.12 MPO RAN
29 Increased shRNA abundance (Z-score > 2) GR00366-A-70 10.12 RAN CD79A MPO
30 Increased shRNA abundance (Z-score > 2) GR00366-A-74 10.12 CD79A
31 Increased shRNA abundance (Z-score > 2) GR00366-A-78 10.12 RAN
32 Increased shRNA abundance (Z-score > 2) GR00366-A-85 10.12 COL4A3BP

Drugs & Therapeutics for Goodpasture Syndrome

Drugs for Goodpasture Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 2, Phase 3 657-24-9 14219 4091
2
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
3
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
4
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
5 Hypoglycemic Agents Phase 2, Phase 3
6 Prednisolone acetate Phase 3
7 glucocorticoids Phase 3
8 Gastrointestinal Agents Phase 3
9 Neuroprotective Agents Phase 3
10 Hormone Antagonists Phase 3
11 Hormones Phase 3
12 Peripheral Nervous System Agents Phase 3
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
14 Vasodilator Agents Phase 3
15 Phosphodiesterase Inhibitors Phase 3
16 Platelet Aggregation Inhibitors Phase 3
17 Prednisolone hemisuccinate Phase 3
18 Prednisolone phosphate Phase 3
19 Immunosuppressive Agents Phase 3
20 Protective Agents Phase 3
21 Antiemetics Phase 3
22 Anti-Inflammatory Agents Phase 3
23 Radiation-Protective Agents Phase 3
24 Methylprednisolone acetate Phase 3
25 Methylprednisolone Hemisuccinate Phase 3
26 Autonomic Agents Phase 3
27 Antineoplastic Agents, Hormonal Phase 3
28 Antioxidants Phase 3
29 Immunoglobulin G Phase 2
30 Immunoglobulins Phase 2
31 Antibodies Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Immunoadsorption in Anti-GBM Glomerulonephritis. Not yet recruiting NCT02765789 Phase 4
2 Comparison Study of Cefazolin Versus Cefazolin Plus Azithromycin Prophylaxis in Post-Cesarean Endometritis Withdrawn NCT01721616 Phase 4
3 Efficacy Study of Metformin Glycinate on Postprandial Lipemia Unknown status NCT02064881 Phase 2, Phase 3
4 Efficacy of Pentoxifylline on Rapidly Progressive Glomerulonephritis Terminated NCT00354198 Phase 3
5 An Open-Label Phase II Study to Evaluate the Efficacy and Safety of IdeS in Anti-GBM Disease (GOOD-IDES) Recruiting NCT03157037 Phase 2

Search NIH Clinical Center for Goodpasture Syndrome

Cochrane evidence based reviews: anti-glomerular basement membrane disease

Genetic Tests for Goodpasture Syndrome

Anatomical Context for Goodpasture Syndrome

MalaCards organs/tissues related to Goodpasture Syndrome:

39
Lung, Kidney, Bone, T Cells, Monocytes, Bone Marrow

The Foundational Model of Anatomy Ontology organs/tissues related to Goodpasture Syndrome:

18
Lung, Kidney

Publications for Goodpasture Syndrome

Articles related to Goodpasture Syndrome:

(show top 50) (show all 61)
id Title Authors Year
1
Goodpasture Syndrome Diagnosed One Year And A Half after the Appearance of the First Symptoms (Case Report). ( 28028414 )
2016
2
Outcomes of patients with Goodpasture syndrome: A nationwide cohort-based study from the French Society of Hemapheresis. ( 27267459 )
2016
3
Goodpasture syndrome and posterior reversible encephalopathy syndrome. ( 25982503 )
2015
4
Clinical management of pregnancy in women with Goodpasture syndrome. ( 25634441 )
2015
5
Severe adult respiratory distress syndrome from Goodpasture syndrome. Survival using extracorporeal membrane oxygenation. ( 25590156 )
2015
6
Prolonged venovenous extracorporeal membrane oxygenation without anticoagulation: a case of Goodpasture syndrome-related pulmonary haemorrhage. ( 24588439 )
2014
7
Reversible posterior leukoencephalopathy syndrome in Goodpasture syndrome. ( 22806294 )
2012
8
Plasma exchange in Goodpasture syndrome associated with Turner's syndrome: A case report. ( 23515881 )
2012
9
Reversible posterior leukoencephalopathy in the course of Goodpasture syndrome. ( 22251235 )
2012
10
Extracorporeal membrane oxygenation as a platform for recovery: a case report of a child with pulmonary hemorrhage, refractory hypoxemic respiratory failure, and new onset goodpasture syndrome. ( 22893987 )
2012
11
Serum antibody-negative Goodpasture syndrome with delta granule pool storage deficiency and eosinophilia. ( 26069804 )
2012
12
Cellular and molecular aspects of Goodpasture syndrome. ( 22218111 )
2012
13
A case of Goodpasture syndrome positive for anti-GBM antibody and MPO-ANCA complicated by a variety of serious infections. ( 21426895 )
2011
14
Epidemiology and etiology of wegener granulomatosis, microscopic polyangiitis, churg-strauss syndrome and goodpasture syndrome: vasculitides with frequent lung involvement. ( 21674413 )
2011
15
Plasma exchange for Goodpasture syndrome. ( 20117054 )
2010
16
Migratory pulmonary infiltrates. Goodpasture syndrome. ( 19124794 )
2009
17
Goodpasture's 1919 article on the etiology of influenza-the historical road to what we now call Goodpasture Syndrome. ( 19680022 )
2009
18
Patient with antibody-negative relapse of Goodpasture syndrome. ( 17474560 )
2007
19
Zebrafish to humans: evolution of the alpha3-chain of type IV collagen and emergence of the autoimmune epitopes associated with Goodpasture syndrome. ( 16254142 )
2006
20
Anti-glomerular basement membrane antibodies in the diagnosis of Goodpasture syndrome: a comparison of different assays. ( 16234289 )
2006
21
Goodpasture syndrome in a pregnant woman. ( 16260570 )
2005
22
Goodpasture syndrome. ( 16183752 )
2005
23
Pathogenesis of Goodpasture syndrome: a molecular perspective. ( 14631560 )
2003
24
Goodpasture syndrome during the course of a SchAPnlein-Henoch purpura. ( 11979333 )
2002
25
Genetically modified bone marrow continuously supplies anti-inflammatory cells and suppresses renal injury in mouse Goodpasture syndrome. ( 11418463 )
2001
26
Renal fibroblast-like cells in Goodpasture syndrome rats. ( 11473642 )
2001
27
Goodpasture syndrome: pathophysiology, diagnosis, and management. ( 12143452 )
2001
28
Reactive oxygen species expose cryptic epitopes associated with autoimmune goodpasture syndrome. ( 10748075 )
2000
29
Goodpasture syndrome. ( 15912919 )
2000
30
Inhibition of monocyte chemoattractant protein-1 expression in tubular epithelium attenuates tubulointerstitial alteration in rat Goodpasture syndrome. ( 10720946 )
2000
31
Goodpasture syndrome. ( 10027952 )
1999
32
Complete recovery of renal function in a dialysis-dependent patient with Goodpasture syndrome. ( 9509464 )
1998
33
Goodpasture syndrome and end-stage renal failure--to transplant or not to transplant? ( 9641155 )
1998
34
Anti-GBM antibodies in Goodpasture syndrome; anatomy of an epitope. ( 9140985 )
1997
35
Susceptibility to anti-glomerular basement membrane disease and Goodpasture syndrome is linked to MHC class II genes and the emergence of T cell-mediated immunity in mice. ( 9410904 )
1997
36
Goodpasture syndrome involving overlap with Wegener's granulomatosis and anti-glomerular basement membrane disease. ( 9355084 )
1997
37
Anti-alpha1(IV) collagen autoantibodies associated with lung adenocarcinoma presenting as the Goodpasture syndrome. ( 8607593 )
1996
38
Sera from patients with anti-GBM nephritis including goodpasture syndrome show heterogenous reactivity to recombinant NC1 domain of type IV collagen alpha chains. ( 8941581 )
1996
39
Pregnancy in a patient with Goodpasture syndrome and renal transplantation. ( 8672189 )
1996
40
Specificity of circulating and tissue-bound autoantibodies in Goodpasture syndrome. ( 8705733 )
1996
41
Goodpasture syndrome: selective removal of anti-alpha 3 (IV) collagen autoantibodies. A potential therapeutic alternative to plasmapheresis. ( 8864724 )
1996
42
Identification of the alpha 3 chain of type IV collagen as the common autoantigen in antibasement membrane disease and Goodpasture syndrome. ( 8589284 )
1995
43
Anti-type IV collagen antibodies in Goodpasture syndrome. ( 8004967 )
1994
44
The alpha 3 chain of type IV collagen induces autoimmune Goodpasture syndrome. ( 8016138 )
1994
45
Goodpasture syndrome: molecular and clinical advances. ( 8041241 )
1994
46
Provocation of pulmonary haemorrhage in Goodpasture syndrome by chlorine gas. ( 8384347 )
1993
47
Pregnancy complicated by Goodpasture syndrome. ( 1565371 )
1992
48
Isolated pulmonary Goodpasture syndrome. ( 1946080 )
1991
49
Goodpasture syndrome. Localization of the epitope for the autoantibodies to the carboxyl-terminal region of the alpha 3(IV) chain of basement membrane collagen. ( 1721062 )
1991
50
Goodpasture syndrome: molecular architecture and function of basement membrane antigen. ( 2671489 )
1989

Variations for Goodpasture Syndrome

Expression for Goodpasture Syndrome

Search GEO for disease gene expression data for Goodpasture Syndrome.

Pathways for Goodpasture Syndrome

Pathways related to Goodpasture Syndrome according to GeneCards Suite gene sharing:

(show all 14)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.69 CD79A COL4A3 COL4A4 COL4A5
2
Show member pathways
12.41 COL4A3 COL4A4 COL4A5 NID1
3 12.3 COL4A3 COL4A4 COL4A5
4
Show member pathways
12.27 COL4A3 COL4A4 COL4A5
5 12.22 COL4A3 COL4A4 COL4A5
6
Show member pathways
11.83 COL4A3 COL4A4 COL4A5
7 11.6 COL4A3 COL4A4 COL4A5
8 11.56 COL4A3 COL4A4 COL4A5
9 11.47 COL4A3 COL4A4 COL4A5
10 11.37 COL4A3 COL4A4 COL4A5
11 11.12 COL4A3 COL4A4 COL4A5
12 10.93 COL4A3 COL4A4 COL4A5
13 10.71 COL4A3 COL4A4 COL4A5 NID1
14 10.7 COL4A3 COL4A4 COL4A5

GO Terms for Goodpasture Syndrome

Cellular components related to Goodpasture Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 proteinaceous extracellular matrix GO:0005578 9.62 COL4A3 COL4A4 COL4A5 NID1
2 collagen trimer GO:0005581 9.56 COL4A3 COL4A3BP COL4A4 COL4A5
3 endoplasmic reticulum lumen GO:0005788 9.54 COL4A3 COL4A4 COL4A5
4 basal lamina GO:0005605 9.33 COL4A4 COL4A5 NID1
5 basement membrane GO:0005604 9.26 COL4A3 COL4A4 COL4A5 NID1
6 collagen type IV trimer GO:0005587 8.8 COL4A3 COL4A4 COL4A5

Biological processes related to Goodpasture Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 collagen catabolic process GO:0030574 9.33 COL4A3 COL4A4 COL4A5
2 collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 9.26 COL4A3 COL4A5
3 extracellular matrix organization GO:0030198 9.26 COL4A3 COL4A4 COL4A5 NID1
4 glomerular basement membrane development GO:0032836 8.8 COL4A3 COL4A4 NID1

Molecular functions related to Goodpasture Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular matrix structural constituent GO:0005201 8.8 COL4A3 COL4A4 COL4A5

Sources for Goodpasture Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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