GOUT
MCID: GT001
MIFTS: 66

Gout (GOUT) malady

Summaries for Gout

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Gout is a common, painful form of arthritis. it causes swollen, red, hot and stiff joints. gout happens when uric acid builds up in your body. uric acid comes from the breakdown of substances called purines. purines are in your body's tissues and in foods, such as liver, dried beans and peas, and anchovies. normally, uric acid dissolves in the blood. it passes through the kidneys and out of the body in urine. but sometimes uric acid can build up and form needle-like crystals. when they form in your joints, it is very painful. the crystals can also cause kidney stones. often, gout first attacks your big toe. it can also attack ankles, heels, knees, wrists, fingers, and elbows. at first, gout attacks usually get better in days. eventually, attacks last longer and happen more often. you are more likely to get gout if you are a man have family member with gout are overweight drink alcohol eat too many foods rich in purines gout can be hard to diagnose. your doctor may take a sample of fluid from an inflamed joint to look for crystals. you can treat gout with medicines. pseudogout has similar symptoms and is sometimes confused with gout. however, it is caused by calcium phosphate, not uric acid. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Gout, also known as gouty arthropathy, is related to hyperuricemia and arthritis. An important gene associated with Gout is HPRT1 (hypoxanthine phosphoribosyltransferase 1), and among its related pathways are Purine metabolism and Purine metabolism. The drugs colchicine and indomethacin and the compounds uric acid and creatinine have been mentioned in the context of this disorder. Affiliated tissues include joint, kidney and liver, and related mouse phenotypes are homeostasis/metabolism and renal/urinary system.

Disease Ontology:8 An arthritis that has material basis in uric acid crystal deposits located in joint.

CDC:3 Gout is a rheumatic disease resulting from deposition of uric acid crystals (monosodium urate) in tissues and fluids within the body. This process is caused by an overproduction or under excretion of uric acid. Certain common medications, alcohol, and dietary foods are known to be contributory factors. Acute gout will typically manifest itself as an acutely red, hot, and swollen joint with excruciating pain. These acute gouty flare-ups respond well to treatment with oral anti-inflammatory medicines and may be prevented with medication and diet changes. Recurrent bouts of acute gout can lead to a degenerative form of chronic arthritis called gouty arthritis.

Wikipedia:63 Gout (also known as podagra when it involves the big toe) is a medical condition usually characterized... more...

Aliases & Classifications for Gout

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Related Diseases for Gout

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17GeneCards, 18GeneDecks
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Diseases in the Gout family:

Gout, Hprt1-Related

Diseases related to Gout via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 130)
idRelated DiseaseScoreTop Affiliating Genes
1hyperuricemia31.3SLC17A3, SLC22A12, HPRT1, XDH, PRPS1, UMOD
2arthritis30.9S100A9, HPRT1, IL1B
3synovitis30.3IL1B
4arthropathy30.3IL1B, S100A9
5lesch-nyhan syndrome30.3APRT, PRPS1, XDH, HPRT1, PNP, ADSL
6atherosclerosis30.2LCAT, S100A9, XDH, IL1B
7hprt-related gout30.2APRT, HPRT1
8phosphoribosylpyrophosphate synthetase superactivity30.2PRPS1
9nephrolithiasis30.1APRT, UMOD, XDH, HPRT1, SLC22A12
10familial juvenile hyperuricemic nephropathy30.1HNF1B, UMOD, HPRT1
11obesity30.1ALDH2, LCAT
12tuberculosis30.0PNP, IL1B
13diabetes mellitus29.7HNF1B, LCAT, UMOD, IL1B, ALDH2
14alzheimer's disease29.7S100A9, HPRT1, IL1B, ALDH2
15cystic kidney29.7UMOD, HNF1B
16liver cirrhosis29.7ALDH2, LCAT
17pseudogout10.6
18kidney disease10.4
19hypertension10.3
20rheumatoid arthritis10.2
21osteoarthritis10.2
22septic arthritis10.1
23bursitis10.1
24myocardial infarction10.1
25familial juvenile hyperuricaemic nephropathy10.1
26reflex sympathetic dystrophy10.1
27mixed connective tissue disease10.1
28gastric ulcer10.1
29autosomal dominant disease10.1
30cerebrovascular disease10.1
31connective tissue disease10.1
32xanthomatosis10.1
33parkinson's disease10.1
34epidural abscess10.1
35nephronophthisis10.1
36glycogen storage disease10.1
37adenine phosphoribosyltransferase deficiency10.1
38umod-associated kidney disease10.1
39gout susceptibility 410.1
40metabolic syndrome x10.0LCAT, APRT, XDH, PNP, ALDH2, ADSL
41leukemia10.0S100A9, APRT, HPRT1, IL1B, PNP, ALDH2
42acute kidney failure10.0SLC22A12, HPRT1, XDH, UMOD
43cork-handlers' disease10.0ALDH2, PNP, IL1B, S100A9
44chronic kidney failure10.0HNF1B, LCAT, APRT, UMOD
45glomerulonephritis10.0IL1B, XDH, UMOD
46purine nucleoside phosphorylase deficiency10.0HPRT1, APRT
47pneumonia10.0XDH, IL1B
48interstitial nephritis10.0APRT, UMOD
49acute urate nephropathy10.0XDH, HPRT1
50renal hypouricemia10.0HPRT1, SLC22A12

Graphical network of the top 20 diseases related to Gout:



Diseases related to gout

Clinical Features for Gout

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Drugs & Therapeutics for Gout

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Gout

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Anatomical Context for Gout

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Gout:

32
Kidney, Liver, Skin, Heart, Bone, Monocytes, Testes, Prostate, Lung, Thyroid, Colon

FMA organs/tissues related to Gout:

14
Joint

Animal Models for Gout or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gout:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.3HNF1B, LCAT, S100A9, APRT, UMOD, XDH
2MP:000536711.2SLC22A12, HNF1B, LCAT, APRT, UMOD, XDH
3MP:000539711.2S100A9, APRT, UMOD, HPRT1, PNP, SLC22A12
4MP:000538710.9HNF1B, S100A9, APRT, UMOD, XDH, HPRT1

Publications for Gout

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50PubMed
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Articles related to Gout:

(show top 50)    (show all 780)
idTitleAuthorsYear
1
Sugar-sweetened beverage consumption: a risk factor for prevalent gout with SLC2A9 genotype-specific effects on serum urate and risk of gout. (24026676)
2013
2
The antinociceptive and anti-inflammatory effects of the crude extract of Jatropha isabellei in a rat gout model. (23127654)
2013
3
Safety profile of anti-gout agents: an update. (24378930)
2013
4
The kidney in hyperuricemia and gout. (23318701)
2013
5
Ultrasound imaging for the rheumatologist. XLVII. Ultrasound of the shoulder in patients with gout and calcium pyrophosphate deposition disease. (24050142)
2013
6
New insights into an old disease: advanced imaging in the diagnosis and management of gout. (23112219)
2013
7
Lifestyle interventions for acute gout. (24186771)
2013
8
Resource use and economic impact of patients with gout: a multicenter, population-wide study. (23313534)
2013
9
When gout involves the spine: five patients including two inaugural cases. (23835305)
2013
10
Factors associated with gout in South Koreans: analysis using the National Health Insurance Corporation and the National Health Screening Exam databases. (23397143)
2013
11
Gout, stone composition and urinary stone risk: a matched case comparative study. (23022002)
2013
12
Gout: from international guidelines to current practice. Results from a physician questionnaire. (24077902)
2013
13
Intraosseous talar pseudotumour: an unusual presentation of gout. (23415761)
2013
14
Black and white: alkaptonuria and gout. (23847272)
2013
15
Gout tophus detection-A comparison of dual-energy CT (DECT) and histology. (24332008)
2013
16
The Gout Assessment Questionnaire 2.0: cross-cultural translation into Dutch, aspects of validity and linking to the International Classification of Functioning, Disability and Health. (24357808)
2013
17
Hypertension, its treatment, hyperuricaemia and gout. (23370375)
2013
18
Gout: the mechanism of urate crystal nucleation and growth. A hypothesis based in facts. (23022233)
2013
19
A urate gene-by-diuretic interaction and gout risk in participants with hypertension: results from the ARIC study. (22753387)
2013
20
Thermography detects subclinical inflammation in chronic tophaceous gout. (22210677)
2012
21
Purine-rich foods: an innocent bystander of gout attacks? (22805973)
2012
22
Intraosseous tophaceous gout in the proximal phalanx of the small finger. (22496182)
2012
23
Rilonacept (interleukin-1 trap) in the prevention of acute gout flares during initiation of urate-lowering therapy: results of a phase II randomized, double-blind, placebo-controlled trial. (22223180)
2012
24
Febuxostat for treating chronic gout. (23152264)
2012
25
New perspectives on the management of gout, a common primary care disorder. (23095435)
2012
26
Living with gout in New Zealand: an exploratory study into people's knowledge about the disease and its treatment. (22426580)
2012
27
Interphalangeal joint involvement of the big toe in gout: a rare presentation. (22659770)
2012
28
Therapeutic perspectives on uricases for gout. (22366146)
2012
29
The gout pipeline crystallizes. (22653201)
2012
30
Value of a short four-joint ultrasound test for gout diagnosis: a pilot study. (23020889)
2012
31
Dual energy CT in gout: a prospective validation study. (22387729)
2012
32
Refractory gout attack. (23304159)
2012
33
Polymorphisms -1082 G/A and -819 C/T in the interleukin-10 gene are not associated with gout susceptibility in the Chinese Han male population. (22788775)
2012
34
Gout measures: Gout Assessment Questionnaire (GAQ, GAQ2.0), and physical measurement of tophi. (22588771)
2011
35
Trends in hyperuricemia and gout prevalence: Nutrition and Health Survey in Taiwan from 1993-1996 to 2005-2008. (21669599)
2011
36
Management of gout in the older adult. (21849262)
2011
37
Sodium-dependent phosphate cotransporter type 1 sequence polymorphisms in male patients with gout. (19556210)
2010
38
A critical reappraisal of allopurinol dosing, safety, and efficacy for hyperuricemia in gout. (19296886)
2009
39
Febuxostat: new drug. Hyperuricaemia: risk of gout attacks. (19585722)
2009
40
Clinical Images: Lumbar spondylolisthesis caused by tophaceous gout. (19116898)
2009
41
Benjamin Franklin's risk factors for gout and stones: from genes and diet to possible lead poisoning. (19244863)
2008
42
Historical review of gout and hyperuricemia investigations]. (18409506)
2008
43
Enhanced osteoclastogenesis in patients with tophaceous gout: urate crystals promote osteoclast development through interactions with stromal cells. (18512794)
2008
44
Febuxostat in the management of hyperuricemia and chronic gout: a review. (19337428)
2008
45
Recent advances in the management of gout and hyperuricemia. (15838244)
2005
46
Recognition and management of gout and hyperuricemia. (14968523)
2003
47
Disseminated cutaneous sporotrichosis: a marker of osteoarticular sporotrichosis masquerading as gout. (11737440)
2001
48
Prepatellar bursitis: a unique presentation of tophaceous gout in an normouricemic patient. (9150094)
1997
49
Uric acid crystals and chemotactic cytokines--pathogenesis of an acute gout attack]. (9446414)
1997
50
Tophaceous gout of the lumbar spine mimicking an epidural abscess: MR features. (8933885)
1996

Genetic Variations for Gout

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Expression for genes affiliated with Gout

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gout

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Pathways for genes affiliated with Gout

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29KEGG, 12EMD Millipore, 53Reactome, 37NCBI BioSystems Database, 49PharmGKB
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Compounds for genes affiliated with Gout

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44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Gout according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1uric acid44 2412.7ADSL, HNF1B, APRT, UMOD, PRPS1, XDH
2creatinine4411.5APRT, UMOD, HPRT1, PNP, SLC22A12, ALDH2
3purine44 2412.4APRT, PRPS1, XDH, HPRT1, PNP, ADSL
4prpp4411.4APRT, PRPS1, HPRT1, PNP, ADSL
5purine nucleoside4411.3APRT, XDH, HPRT1, PNP, ADSL
6hypoxanthine44 11 2413.3APRT, XDH, HPRT1, PNP, ADSL
7xanthine44 2412.3APRT, XDH, HPRT1, PNP, ADSL
8adenine44 11 2413.3APRT, XDH, HPRT1, PNP, ADSL
9glutamate4411.3LCAT, GLUD2, HPRT1, PNP, ALDH2, ADSL
10allopurinol44 49 1113.3APRT, UMOD, XDH, HPRT1
11inosine44 2412.2APRT, XDH, HPRT1, PNP
12thymidine44 2412.2APRT, HPRT1, IL1B, PNP, ADSL
13inosine monophosphate4411.2ADSL, PNP, HPRT1, APRT
14acetaldehyde44 28 2413.2LCAT, XDH, HPRT1, ALDH2
15nucleoside4411.2APRT, HPRT1, PNP, ADSL
16cysteine4411.2LCAT, UMOD, XDH, HPRT1, PNP, ALDH2
17guanine44 11 2413.2PNP, HPRT1, XDH, APRT
182,8-dihydroxyadenine4411.2HPRT1, XDH, APRT
19methotrexate44 49 1113.2S100A9, HPRT1, IL1B, SLC22A11
20adenylosuccinate4411.1ADSL, PNP, APRT
21molybdenum44 2412.1XDH, PNP, ADSL
22thiopurine4411.1PNP, HPRT1, XDH
23Adenosine monophosphate11 2412.1ADSL, HPRT1, PRPS1, APRT
245-methylthioadenosine4411.1APRT, PNP, ADSL
25probenecid44 28 59 49 1115.1XDH, SLC22A11, SLC22A12
26h2o24411.1S100A9, APRT, XDH, HPRT1, PNP
279-deazaguanine44 1112.1PNP, HPRT1
28Alpha-Phosphoribosylpyrophosphoric Acid1111.0APRT, HPRT1
298-azaguanine44 1112.0HPRT1, PNP
306-thiouric acid4411.0XDH, HPRT1
31febuxostat59 4412.0PNP, XDH
32benzbromarone4411.0SLC22A12, XDH
33aaph4411.0LCAT, XDH
344-hydroxynonenal44 2412.0ALDH2, XDH, LCAT
35pyrophosphate44 2412.0APRT, PRPS1, HPRT1, PNP
36ethyl methanesulfonate4411.0HPRT1, APRT
372,3-dideoxyadenosine4411.0IL1B, PNP
38pyrazinamide44 49 1113.0XDH, SLC22A12
39mercaptopurine49 1111.9XDH, HPRT1
40monosodium urate4410.9S100A9, IL1B
412-amino-3-methylimidazo(4,5-f)quinoline4410.9APRT, HPRT1
42calcium oxalate4410.9APRT, UMOD
43azathioprine44 49 2 1113.9PNP, HPRT1, XDH
44tiazofurin4410.9HPRT1
454-ipp5910.8S100A9, IL1B
46alpha tocopherol4410.7LCAT, XDH, ALDH2
47git 275910.7S100A9, IL1B
48deoxyadenosine44 2411.6PNP, APRT
49guanylate4410.6ALDH2, PNP, HPRT1
50didanosine44 1111.3PNP, HPRT1

GO Terms for genes affiliated with Gout

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16Gene Ontology
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Cellular components related to Gout according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:01632410.8SLC17A3, SLC22A12, SLC22A11, UMOD

Biological processes related to Gout according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:04428111.3LCAT, APRT, PRPS1, XDH, HPRT1, PNP
2purine nucleobase metabolic processGO:00614411.3ADSL, PNP, HPRT1, XDH, PRPS1, APRT
3nucleobase-containing small molecule metabolic processGO:05508611.2APRT, XDH, HPRT1, PNP, ADSL
4purine nucleotide biosynthetic processGO:00616411.0PRPS1, HPRT1, ADSL
5urate metabolic processGO:04641510.9SLC17A3, SLC22A12, SLC22A11
6purine-containing compound salvageGO:04310110.9PNP, HPRT1, APRT
7urate biosynthetic processGO:03441810.8PRPS1, PNP
8urate transportGO:01574710.8SLC22A12, SLC17A3
9adenine salvageGO:00616810.7APRT, HPRT1
10purine ribonucleoside salvageGO:00616610.6HPRT1, APRT
11grooming behaviorGO:00762510.6HPRT1, APRT
12organic anion transportGO:01571110.5SLC17A3, SLC22A11
13purine nucleotide catabolic processGO:00619510.3PNP, XDH

Molecular functions related to Gout according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1organic anion transmembrane transporter activityGO:00851410.6SLC17A3, SLC22A11
2urate transmembrane transporter activityGO:01514310.3SLC17A3, SLC22A12

Products for genes affiliated with Gout

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  • Antibodies
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Sources for Gout

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet