GOUT
MCID: GT001
MIFTS: 66

Gout (GOUT) malady

Genetic diseases (common), Bone diseases categories
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Summaries for Gout

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MedlinePlus:33 Gout is a common, painful form of arthritis. it causes swollen, red, hot and stiff joints. gout happens when uric acid builds up in your body. uric acid comes from the breakdown of substances called purines. purines are in your body's tissues and in foods, such as liver, dried beans and peas, and anchovies. normally, uric acid dissolves in the blood. it passes through the kidneys and out of the body in urine. but sometimes uric acid can build up and form needle-like crystals. when they form in your joints, it is very painful. the crystals can also cause kidney stones. often, gout first attacks your big toe. it can also attack ankles, heels, knees, wrists, fingers, and elbows. at first, gout attacks usually get better in days. eventually, attacks last longer and happen more often. you are more likely to get gout if you are a man have family member with gout are overweight drink alcohol eat too many foods rich in purines gout can be hard to diagnose. your doctor may take a sample of fluid from an inflamed joint to look for crystals. you can treat gout with medicines. pseudogout has similar symptoms and is sometimes confused with gout. however, it is caused by calcium phosphate, not uric acid. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Gout, also known as gouty arthropathy, is related to phosphoribosylpyrophosphate synthetase superactivity and hprt-related gout. An important gene associated with Gout is HPRT1 (hypoxanthine phosphoribosyltransferase 1), and among its related pathways are One carbon pool by folate and purine nucleotide salvage. The drugs indomethacin and sulindac and the compounds ethyl methanesulfonate and 2-amino-3-methylimidazo(4,5-f)quinoline have been mentioned in the context of this disorder. Affiliated tissues include joint, kidney and liver, and related mouse phenotypes are hematopoietic system and renal/urinary system.

Disease Ontology:8 An arthritis that has material basis in uric acid crystal deposits located in joint.

CDC:3 Gout is a rheumatic disease resulting from deposition of uric acid crystals (monosodium urate) in tissues and fluids within the body. This process is caused by an overproduction or under excretion of uric acid. Certain common medications, alcohol, and dietary foods are known to be contributory factors. Acute gout will typically manifest itself as an acutely red, hot, and swollen joint with excruciating pain. These acute gouty flare-ups respond well to treatment with oral anti-inflammatory medicines and may be prevented with medication and diet changes. Recurrent bouts of acute gout can lead to a degenerative form of chronic arthritis called gouty arthritis.

Wikipedia:65 Gout (also known as podagra when it involves the big toe) is a medical condition usually characterized... more...

Aliases & Classifications for Gout

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Related Diseases for Gout

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Diseases in the Gout family:

Gout, Hprt1-Related

Diseases related to Gout via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1phosphoribosylpyrophosphate synthetase superactivity30.9PRPS1
2hprt-related gout30.8APRT, HPRT1
3familial juvenile hyperuricemic nephropathy30.2HPRT1, HNF1B, UMOD
4nephrolithiasis30.2XDH, APRT, UMOD
5hyperuricemia30.2HPRT1, SLC17A3, XDH, APRT, PRPS1, UMOD
6cystic kidney29.9UMOD, HNF1B
7lesch-nyhan syndrome29.9HPRT1, PRPS1, ADSL, APRT, XDH
8diabetes mellitus29.1UMOD, HNF1B, ALDH2
9pseudogout10.7
10arthritis10.7
11kidney disease10.4
12hypertension10.4
13arthropathy10.3
14familial juvenile hyperuricaemic nephropathy10.3
15blindness10.3
16renal hypouricemia10.3HPRT1, SLC22A12
17rheumatoid arthritis10.3
18insulin resistance10.3
19acute urate nephropathy10.3XDH, HPRT1
20purine nucleoside phosphorylase deficiency10.2HPRT1, APRT
21atherosclerosis10.2
22osteoarthritis10.2
23synovitis10.2
24myocardial infarction10.2
25septic arthritis10.2
26bursitis10.2
27interstitial nephritis10.2UMOD, APRT
28reflex sympathetic dystrophy10.1
29gastric ulcer10.1
30cerebrovascular disease10.1
31xanthomatosis10.1
32ivemark syndrome10.1
33glycogen storage disease10.1
34obesity10.1
35parkinson's disease10.1
36kearns-sayre syndrome10.1
37nephronophthisis10.1
38epidural abscess10.1
39adenine phosphoribosyltransferase deficiency10.1
40umod-associated kidney disease10.1
41cardiovascular disease risk factor10.1
42gout susceptibility 410.1
43developmental disabilities10.1HPRT1, HNF1B
44prostate cancer10.0
45systemic lupus erythematosus10.0
46factor xii deficiency10.0
47hypercalcemia10.0
48psoriatic arthritis10.0
49artery disease10.0
50cervicitis10.0

Graphical network of the top 20 diseases related to Gout:



Diseases related to gout

Symptoms for Gout

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Drugs & Therapeutics for Gout

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Genetic Tests for Gout

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Anatomical Context for Gout

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MalaCards organs/tissues related to Gout:

32
Kidney, Liver, Skin, Bone, Heart, Neutrophil, Testes, Lung, Prostate, Monocytes, Colon, Thyroid

FMA organs/tissues related to Gout:

14
Joint

Animal Models for Gout or affiliated genes

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MGI Mouse Phenotypes related to Gout:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.1SLC22A12, ALDH2, UMOD, HPRT1, APRT
2MP:00053678.1SLC22A12, HNF1B, UMOD, HPRT1, APRT, XDH
3MP:00107687.3XDH, APRT, HPRT1, HNF1B, ALDH2, SLC22A12
4MP:00053877.3XDH, APRT, HPRT1, UMOD, HNF1B, ALDH2
5MP:00053787.2XDH, APRT, HPRT1, UMOD, HNF1B, ALDH2
6MP:00053767.1XDH, APRT, HPRT1, UMOD, HNF1B, ALDH2

Publications for Gout

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Articles related to Gout:

(show top 50)    (show all 801)
idTitleAuthorsYear
1
Response to: 'Risk of vascular disease with gout: overadjustment of the statistical analyses?' by van Durme et al. (25351520)
2014
2
Risk of incident diabetes in patients with gout: A cohort study. (25332119)
2014
3
Prevalence and correlates of gout in a large cohort of patients with chronic kidney disease: the German Chronic Kidney Disease (GCKD) study. (25395390)
2014
4
Frequency of CYP2C9 polymorphisms in polynesian people and potential relevance to management of gout with benzbromarone. (23932726)
2013
5
A qualitative and quantitative analysis of the characteristics of gout patient education resources. (23322247)
2013
6
Obstructive sleep apnoea, gout and cardiovascular risk: a worth studying association. (23937998)
2013
7
Rilonacept for gout flare prevention during initiation of uric acid-lowering therapy: results from the PRESURGE-2 international, phase 3, randomized, placebo-controlled trial. (23485476)
2013
8
The distribution of urate deposition within the extremities in gout: a review of 148 dual-energy CT cases. (24337414)
2013
9
Polyarticular sonographic assessment of gout: a hospital-based cross-sectional study. (23142256)
2013
10
Common variants of a urate-associated gene LRP2 are not associated with gout susceptibility. (24366390)
2013
11
Uric acid as a danger signal in gout and its comorbidities. (22945591)
2013
12
Increased prevalence of simple renal cysts in patients with gout. (22453524)
2013
13
Intra-articular glucocorticoids for acute gout. (23633379)
2013
14
Sugar-sweetened beverage consumption: a risk factor for prevalent gout with SLC2A9 genotype-specific effects on serum urate and risk of gout. (24026676)
2013
15
Tophus burden reduction with pegloticase: results from phase 3 randomized trials and open-label extension in patients with chronic gout refractory to conventional therapy. (24286509)
2013
16
Monosodium urate (gout) crystals, an uncommon finding in ThinPrep synovial fluid cytology. (21964923)
2013
17
Metabolic Interactions of Purine Derivatives with Human ABC Transporter ABCG2: Genetic Testing to Assess Gout Risk. (24287461)
2013
18
A small disturbance, but a serious disease: the possible mechanism of D52H-mutant of human PRS1 that causes gout. (23509005)
2013
19
Benefit restrictions and gout treatment. (24156646)
2013
20
OMERACT Endorsement of Measures of Outcome for Studies of Acute Gout. (24334651)
2013
21
Women with gout: efficacy and safety of urate-lowering with febuxostat and allopurinol. (22052584)
2012
22
Spinal gout: a great mimicker. A case report and literature review. (24029100)
2012
23
Silent gout: an unusual presentation in diabetic neuropathy. (22854386)
2012
24
Gout and osteoarthritis: a pathogenetic link? (22867976)
2012
25
Tophaceous pustule-like rash in a patient with gout. (22210683)
2012
26
Prescription and dosing of urate-lowering therapy, rather than patient behaviours, are the key modifiable factors associated with targeting serum urate in gout. (22978848)
2012
27
Improved health-related quality of life and physical function in patients with refractory chronic gout following treatment with pegloticase: evidence from phase III randomized controlled trials. (22660805)
2012
28
Crystal arthritis: Canakinumab relieves gout flares when treatment options are limited. (22641137)
2012
29
Juvenile gout: rare and aggressive. (22602839)
2012
30
Febuxostat: a novel agent for management of hyperuricemia in gout. (23112391)
2011
31
Gout measures: Gout Assessment Questionnaire (GAQ, GAQ2.0), and physical measurement of tophi. (22588771)
2011
32
How clinical and research failures lead to suboptimal prescribing: the example of chronic gout. (22134968)
2011
33
The mechanisms of inflammation in gout and pseudogout (CPP-induced arthritis). (22303529)
2011
34
Genetic analysis of ABCG2 gene C421A polymorphism with gout disease in Chinese Han male population. (19921266)
2010
35
The cyclic GMP-dependent protein kinase II gene associates with gout disease: identified by genome-wide analysis and case-control study. (18678579)
2009
36
Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout. (19506252)
2009
37
A critical reappraisal of allopurinol dosing, safety, and efficacy for hyperuricemia in gout. (19296886)
2009
38
Benjamin Franklin's risk factors for gout and stones: from genes and diet to possible lead poisoning. (19244863)
2008
39
A case of verrucous carcinoma (epithelioma cuniculatum) of the heel mimicking infected epidermal cyst and gout. (19825731)
2008
40
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. (18327257)
2008
41
Tophaceous gout of the lumbar spine mimicking pyogenic discitis. (17197341)
2007
42
Markers of vascular endothelium activation in gout]. (15989007)
2005
43
Purine metabolites in gout and asymptomatic hyperuricemia: analysis by HPLC-electrospray tandem mass spectrometry. (16120958)
2005
44
Reduced incidence of hyperuricemia, gout, and renal failure following liver transplantation in comparison to heart transplantation: a long-term follow-up study. (15239625)
2004
45
Evaluation of crystals in formalin-fixed, paraffin-embedded tissue sections for the differential diagnosis of pseudogout, gout, and tumoral calcinosis. (11504841)
2001
46
Gout, uric acid and purine metabolism in paediatric nephrology. (8439471)
1993
47
Gout and pseudogout in hospitalized patients. (8257255)
1993
48
Recurrent hemarthrosis associated with gout. (1555350)
1992
49
Coexistence of rheumatoid nodulosis and gout. (3772930)
1986
50
Gout and pseudogout precipitated by parathyroidectomy. (7112087)
1982

Variations for Gout

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Expression for genes affiliated with Gout

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Expression patterns in normal tissues for genes affiliated with Gout

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Pathways for genes affiliated with Gout

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Pathways related to Gout according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
One Carbon Metabolism37
dTMP de novo biosynthesis (mitochondrial)37
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate37
Trans-sulfuration and one carbon metabolism37
methionine salvage37
Methionine metabolism60
9.8HPRT1, PRPS1
2
Show member pathways
guanosine nucleotides de novo biosynthesis37
guanosine ribonucleotides de novo biosynthesis37
adenosine ribonucleotides de novo biosynthesis37
purine nucleotides de novo biosynthesis37
9.8HPRT1, APRT
39.7SLC22A12, XDH
49.4HNF1B, UMOD
59.2HPRT1, PRPS1, ADSL
6
Show member pathways
Retinol metabolism60
9.2XDH, ALDH2
7
Show member pathways
8.9XDH, HPRT1, ALDH2
8
Show member pathways
purine deoxyribonucleosides degradation37
purine nucleotides degradation37
adenine and adenosine salvage II37
adenine and adenosine salvage III37
oxidized GTP and dGTP detoxification37
urate biosynthesis/inosine 5-phosphate degradation37
adenine and adenosine salvage I37
purine ribonucleosides degradation to ribose-1-phosphate37
inosine-5-phosphate biosynthesis37
guanosine nucleotides degradation37
guanine and guanosine salvage37
adenosine nucleotides degradation37
5-aminoimidazole ribonucleotide biosynthesis37
8.7XDH, APRT, ADSL, HPRT1
9
Show member pathways
UTP and CTP dephosphorylation II37
ATP ITP metabolism60
purine deoxyribonucleosides salvage37
8.3HPRT1, PRPS1, ADSL, APRT, XDH
10
Show member pathways
7.5ALDH2, HPRT1, PRPS1, ADSL, APRT, XDH

Compounds for genes affiliated with Gout

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Compounds related to Gout according to GeneCards/GeneDecks:

(show all 46)
idCompoundScoreTop Affiliating Genes
1ethyl methanesulfonate4410.1HPRT1, APRT
22-amino-3-methylimidazo(4,5-f)quinoline4410.1HPRT1, APRT
36-thiouric acid4410.1XDH, HPRT1
4tiazofurin4410.1XDH, HPRT1
5bpde4410.1HPRT1, APRT
6benzbromarone4410.1XDH, SLC22A12
7mercaptopurine50 1111.1HPRT1, XDH
8pyrazinamide44 50 1112.1XDH, SLC22A12
9didanosine44 50 1112.0HPRT1, XDH
10phip4410.0APRT, HPRT1
11thiopurine4410.0XDH, HPRT1
126 mercaptopurine4410.0HPRT1, XDH
13calcium oxalate449.9UMOD, APRT
14probenecid28 44 61 50 1113.8SLC22A12, XDH
155-Aminoimidazole-4-carboxamide249.8APRT, ADSL
16Phosphoribosyl pyrophosphate249.8HPRT1, PRPS1, APRT
17benzo(a)pyrene449.8HPRT1, APRT
18adenylosuccinate449.8APRT, ADSL
19nicotinamide44 1110.8HNF1B, HPRT1
202,8-dihydroxyadenine449.7HPRT1, APRT, XDH
21molybdenum44 2410.7ADSL, XDH
22inosine44 2410.7XDH, APRT, HPRT1
235-methylthioadenosine449.7APRT, ADSL
24losartan44 50 28 1112.7SLC22A12, XDH
25phosphoric acid44 2410.7APRT, PRPS1, HPRT1
26aicar44 24 1111.6ADSL, APRT
27pyrophosphate44 2410.6HPRT1, PRPS1, APRT
28guanine44 24 1111.6HPRT1, APRT, XDH
29inosine monophosphate449.6HPRT1, ADSL, APRT
30nucleoside449.5HPRT1, ADSL, APRT
31peroxynitrite449.4UMOD, XDH
32betacarotene449.4HPRT1, ALDH2
33acetaldehyde28 44 2411.3ALDH2, HPRT1, XDH
34prpp449.2APRT, ADSL, PRPS1, HPRT1
35allopurinol44 50 1111.2UMOD, HPRT1, APRT, XDH
36Adenosine monophosphate24 1110.2APRT, ADSL, PRPS1, HPRT1
37purine nucleoside449.1XDH, APRT, ADSL, HPRT1
38hypoxanthine44 24 1111.1HPRT1, ADSL, APRT, XDH
39xanthine44 2410.1XDH, APRT, ADSL, HPRT1
40adenine44 24 1111.1XDH, APRT, ADSL, HPRT1
41thymidine44 249.8HPRT1, ADSL, APRT
42purine44 249.8XDH, APRT, ADSL, PRPS1, HPRT1
43arginine448.6ALDH2, HNF1B, HPRT1, XDH
44cysteine448.6XDH, HPRT1, UMOD, ALDH2
45creatinine447.9APRT, ADSL, HPRT1, UMOD, ALDH2, SLC22A12
46uric acid44 248.4SLC22A12, XDH, APRT, ADSL, PRPS1, HPRT1

GO Terms for genes affiliated with Gout

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Cellular components related to Gout according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1brush border membraneGO:0315269.5SLC22A12, SLC17A3
2apical plasma membraneGO:0163249.2UMOD, SLC17A3, SLC22A12
3cytosolGO:0058298.3HPRT1, PRPS1, ADSL, APRT, XDH
4extracellular vesicular exosomeGO:0700628.1SLC22A12, ALDH2, UMOD, HPRT1, APRT

Biological processes related to Gout according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1organic acid transportGO:01584910.0SLC22A12, SLC17A3
2adenine salvageGO:0061689.9HPRT1, APRT
3urate transportGO:0157479.9SLC22A12, SLC17A3
4purine ribonucleoside salvageGO:0061669.8APRT, HPRT1
5urate metabolic processGO:0464159.8SLC22A12, SLC17A3
6purine-containing compound salvageGO:0431019.7APRT, HPRT1
7AMP biosynthetic processGO:0061679.6ADSL, PRPS1
8lactationGO:0075959.6APRT, XDH
9grooming behaviorGO:0076259.5HPRT1, APRT
10purine nucleotide biosynthetic processGO:0061649.5ADSL, PRPS1, HPRT1
11nucleobase-containing small molecule metabolic processGO:0550868.9XDH, APRT, ADSL, HPRT1
12purine nucleobase metabolic processGO:0061448.6HPRT1, PRPS1, ADSL, APRT, XDH
13small molecule metabolic processGO:0442817.7XDH, APRT, ADSL, PRPS1, HPRT1, ALDH2

Molecular functions related to Gout according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1urate transmembrane transporter activityGO:0151439.8SLC22A12, SLC17A3
2AMP bindingGO:0162089.6PRPS1, APRT
3electron carrier activityGO:0090559.2ALDH2, XDH
4protein homodimerization activityGO:0428038.6XDH, PRPS1, HPRT1, HNF1B

Products for genes affiliated with Gout

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Sources for Gout

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25ICD10
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27ICD9CM
28IUPHAR
29KEGG
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