GOUT
MCID: GT001
MIFTS: 66

Gout (GOUT) malady

Summaries for Gout

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Gout is a common, painful form of arthritis. it causes swollen, red, hot and stiff joints. gout happens when uric acid builds up in your body. uric acid comes from the breakdown of substances called purines. purines are in your body's tissues and in foods, such as liver, dried beans and peas, and anchovies. normally, uric acid dissolves in the blood. it passes through the kidneys and out of the body in urine. but sometimes uric acid can build up and form needle-like crystals. when they form in your joints, it is very painful. the crystals can also cause kidney stones. often, gout first attacks your big toe. it can also attack ankles, heels, knees, wrists, fingers, and elbows. at first, gout attacks usually get better in days. eventually, attacks last longer and happen more often. you are more likely to get gout if you are a man have family member with gout are overweight drink alcohol eat too many foods rich in purines gout can be hard to diagnose. your doctor may take a sample of fluid from an inflamed joint to look for crystals. you can treat gout with medicines. pseudogout has similar symptoms and is sometimes confused with gout. however, it is caused by calcium phosphate, not uric acid. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Gout, also known as gouty arthropathy, is related to hyperuricemia and arthritis. An important gene associated with Gout is HPRT1 (hypoxanthine phosphoribosyltransferase 1), and among its related pathways are Purine metabolism and Purine metabolism. The drugs indomethacin and sulindac and the compounds uric acid and creatinine have been mentioned in the context of this disorder. Affiliated tissues include joint, skin and liver, and related mouse phenotypes are homeostasis/metabolism and renal/urinary system.

Disease Ontology:8 An arthritis that has material basis in uric acid crystal deposits located in joint.

CDC:3 Gout is a rheumatic disease resulting from deposition of uric acid crystals (monosodium urate) in tissues and fluids within the body. This process is caused by an overproduction or under excretion of uric acid. Certain common medications, alcohol, and dietary foods are known to be contributory factors. Acute gout will typically manifest itself as an acutely red, hot, and swollen joint with excruciating pain. These acute gouty flare-ups respond well to treatment with oral anti-inflammatory medicines and may be prevented with medication and diet changes. Recurrent bouts of acute gout can lead to a degenerative form of chronic arthritis called gouty arthritis.

Wikipedia:64 Gout (also known as podagra when it involves the big toe) is a medical condition usually characterized... more...

Aliases & Classifications for Gout

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 25ICD10
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Related Diseases for Gout

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Gout via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 115)
idRelated DiseaseScoreTop Affiliating Genes
1hyperuricemia31.3SLC17A3, SLC22A12, HPRT1, XDH, PRPS1, UMOD
2arthritis30.9S100A9, HPRT1, IL1B
3synovitis30.4IL1B
4insulin resistance30.3LCAT, HNF1B
5lesch-nyhan syndrome30.3APRT, PRPS1, XDH, HPRT1, PNP, ADSL
6atherosclerosis30.3LCAT, S100A9, XDH, IL1B
7hprt-related gout30.2APRT, HPRT1
8phosphoribosylpyrophosphate synthetase superactivity30.2PRPS1
9arthropathy30.2IL1B, S100A9
10nephrolithiasis30.1APRT, UMOD, XDH, HPRT1, SLC22A12
11familial juvenile hyperuricemic nephropathy30.1HNF1B, UMOD, HPRT1
12tuberculosis30.0PNP, IL1B
13renal hypouricemia29.8HPRT1, SLC22A12
14alzheimer's disease29.8S100A9, HPRT1, IL1B, ALDH2
15pseudogout10.7
16osteoarthritis10.2
17synovitis, chronic10.2
18septic arthritis10.2
19familial juvenile hyperuricaemic nephropathy10.2
20reflex sympathetic dystrophy10.1
21mixed connective tissue disease10.1
22gastric ulcer10.1
23autosomal dominant disease10.1
24xanthomatosis10.1
25ivemark syndrome10.1
26epidural abscess10.1
27nephronophthisis10.1
28n syndrome10.1
29adenine phosphoribosyltransferase deficiency10.1
30umod-associated kidney disease10.1
31cardiovascular disease risk factor10.1
32gout susceptibility 410.1
33coronary artery disease,10.0
34systemic lupus erythematosus10.0
35hypercalcemia10.0
36spondyloarthropathy10.0
37chondrocalcinosis 210.0
38gout, hprt1-related10.0
39chronic pain10.0
40coronary heart disease10.0
41metabolic syndrome x10.0LCAT, APRT, XDH, PNP, ALDH2, ADSL
42leukemia10.0S100A9, APRT, HPRT1, IL1B, PNP, ALDH2
43diabetes mellitus10.0HNF1B, LCAT, UMOD, IL1B, ALDH2
44acute kidney failure10.0SLC22A12, HPRT1, XDH, UMOD
45cork-handlers' disease10.0ALDH2, PNP, IL1B, S100A9
46chronic kidney failure10.0HNF1B, LCAT, APRT, UMOD
47glomerulonephritis10.0IL1B, XDH, UMOD
48purine nucleoside phosphorylase deficiency10.0HPRT1, APRT
49pneumonia10.0XDH, IL1B
50interstitial nephritis10.0APRT, UMOD

Graphical network of the top 20 diseases related to Gout:



Diseases related to gout

Clinical Features for Gout

Drugs & Therapeutics for Gout

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Gout

Anatomical Context for Gout

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Gout:

33
Skin, Liver, Spinal cord, Brain, Kidney, Lung, Bone marrow, Heart, Skeletal muscle, Colon, Thyroid, Prostate, Monocytes, T cells, B cells, Fetal brain, Fetal liver, Fetal lung, Fetal thyroid

FMA organs/tissues related to Gout:

14
Joint

Animal Models for Gout or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Gout

Sources:
51PubMed
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Articles related to Gout:

(show top 50)    (show all 967)
idTitleAuthorsYear
1
A common variant of leucine-rich repeat-containing 16A (LRRC16A) gene is associated with gout susceptibility. (24318514)
2014
2
Low-dose aspirin use and recurrent gout attacks. (23345599)
2014
3
Common variants of a urate-associated gene LRP2 are not associated with gout susceptibility. (24366390)
2013
4
OMERACT Endorsement of Measures of Outcome for Studies of Acute Gout. (24334651)
2013
5
Tianma gouteng yin as adjunctive treatment for essential hypertension: a systematic review of randomized controlled trials. (23710230)
2013
6
Ultrasound imaging for the rheumatologist. XLVII. Ultrasound of the shoulder in patients with gout and calcium pyrophosphate deposition disease. (24050142)
2013
7
Clinical and health care use characteristics of patients newly starting allopurinol, febuxostat, and colchicine for the treatment of gout. (23861232)
2013
8
New classification criteria for gout: a framework for progress. (23611919)
2013
9
Elevation of proinflammatory cytokines in patients with Aicardi-GoutiA"res syndrome. (23408864)
2013
10
Allopurinol versus rilonacept for the prevention of gout flares: comment on the article by Schumacher et al. (23281274)
2013
11
Demographic and clinical features of gout patients in Turkey: a multicenter study. (22588430)
2013
12
Association of kidney disease with prevalent gout in the United States in 1988-1994 and 2007-2010. (23312548)
2013
13
Women with gout: efficacy and safety of urate-lowering with febuxostat and allopurinol. (22052584)
2012
14
Sonographic appearance of synovial crystal deposits in 2 patients with gout. (23204314)
2012
15
Genetic architecture for susceptibility to gout in the KARE cohort study. (22513714)
2012
16
National prevalence of gout derived from administrative health data in Aotearoa New Zealand. (22253023)
2012
17
Imaging: Dual-energy CT useful when assessing tophaceous gout. (22249161)
2012
18
Gout: a step forward. (23089269)
2012
19
Association between gout and all-cause as well as cardiovascular mortality: a systematic review. (22350606)
2012
20
New perspectives on the management of gout, a common primary care disorder. (23095435)
2012
21
Tophaceous gout in the elderly: a clinical case review. (22367095)
2012
22
Quantification of tissue uric acid levels in a Harris's hawk with visceral gout. (22017058)
2011
23
The year in gout - 2010-2011. (22035440)
2011
24
The genetic basis of hyperuricaemia and gout. (20472486)
2011
25
Multiarticular chronic tophaceous gout with severe and multiple ulcerations: a case report. (21854566)
2011
26
Images in clinical medicine. Gout nodulosis. (21916637)
2011
27
Genetic analysis of ABCG2 gene C421A polymorphism with gout disease in Chinese Han male population. (19921266)
2010
28
Reconciling neuroimaging and clinical findings in Aicardi-GoutiA"res syndrome: an autoimmune-mediated encephalopathy. (20581073)
2010
29
Band assignment in hemoglobin porphyrin ring spectrum: using four-orbital model of Gouterman. (19758117)
2010
30
Intracerebral large artery disease in Aicardi-GoutiA"res syndrome implicates SAMHD1 in vascular homeostasis. (20653736)
2010
31
Aicardi-GoutiA"res syndrome: cutaneous, laboratory, and radiologic findings: a case report. (20199418)
2010
32
Gout, hyperuricemia, and Parkinson's disease: a protective effect? (20425025)
2010
33
Febuxostat (Uloric) for chronic treatment of gout. (19448587)
2009
34
Elevated pterins in cerebral spinal fluid--biochemical marker of Aicardi-GoutiA"res syndrome. (19694776)
2009
35
Tophaceous gout with congenital dyserythropoietic anemia. (19902585)
2009
36
Effect of metformin on the clinical course of gout and insulin resistance]. (19705791)
2009
37
Analysis of polymorphisms in the promoter region and protein levels of interleukin-6 gene among gout patients. (19032817)
2008
38
Pegloticase, a polyethylene glycol conjugate of uricase for the potential intravenous treatment of gout. (18393109)
2008
39
A second locus for Aicardi-Goutieres syndrome at chromosome 13q14-21. (15908569)
2006
40
Gout in 2006: the perfect storm. (17121496)
2006
41
The management of hyperuricemia and gout in patients with heart failure. (12167377)
2002
42
Aicardi-GoutiA"res syndrome: special type early-onset encephalopathy. (12365357)
2002
43
Gouty arthritis in a patient with Ivemark syndrome. (8701391)
1996
44
Apolipoprotein E phenotypes in patients with gout: relation with hypertriglyceridaemia. (7794039)
1995
45
Gout masquerading as rheumatoid vasculitis. (8182655)
1994
46
Gout and pseudogout: crystal-induced arthropathies. (7014045)
1981
47
Crystal induced arthritis: gout and pseudogout. (708317)
1978
48
Adenine phosphoribosyltransferase deficiency in a female with gout. (4791205)
1973
49
Calcific tendinitis and soft-tissue calcification resembling gout. (5694143)
1968
50
Case for Diagnosis (? Parapsoriasis en Gouttes). (19983562)
1924

Genetic Variations for Gout

Expression for genes affiliated with Gout

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gout

Search GEO for disease gene expression data for Gout.

Pathways for genes affiliated with Gout

Sources:
30KEGG, 12EMD Millipore, 54Reactome, 38NCBI BioSystems Database, 50PharmGKB
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Compounds for genes affiliated with Gout

Sources:
45Novoseek, 24HMDB, 11DrugBank, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Gout according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1uric acid45 2412.7ADSL, HNF1B, APRT, UMOD, PRPS1, XDH
2creatinine4511.5APRT, UMOD, HPRT1, PNP, SLC22A12, ALDH2
3purine45 2412.4APRT, PRPS1, XDH, HPRT1, PNP, ADSL
4prpp4511.4APRT, PRPS1, HPRT1, PNP, ADSL
5purine nucleoside4511.3APRT, XDH, HPRT1, PNP, ADSL
6hypoxanthine45 11 2413.3APRT, XDH, HPRT1, PNP, ADSL
7xanthine45 2412.3APRT, XDH, HPRT1, PNP, ADSL
8adenine45 11 2413.3APRT, XDH, HPRT1, PNP, ADSL
9glutamate4511.3LCAT, GLUD2, HPRT1, PNP, ALDH2, ADSL
10allopurinol45 50 1113.3APRT, UMOD, XDH, HPRT1
11inosine45 2412.2APRT, XDH, HPRT1, PNP
12thymidine45 2412.2APRT, HPRT1, IL1B, PNP, ADSL
13inosine monophosphate4511.2ADSL, PNP, HPRT1, APRT
14acetaldehyde45 29 2413.2LCAT, XDH, HPRT1, ALDH2
15nucleoside4511.2APRT, HPRT1, PNP, ADSL
16cysteine4511.2LCAT, UMOD, XDH, HPRT1, PNP, ALDH2
17guanine45 11 2413.2PNP, HPRT1, XDH, APRT
182,8-dihydroxyadenine4511.2HPRT1, XDH, APRT
19methotrexate45 50 1113.2S100A9, HPRT1, IL1B, SLC22A11
20adenylosuccinate4511.1ADSL, PNP, APRT
21molybdenum45 2412.1XDH, PNP, ADSL
22thiopurine4511.1PNP, HPRT1, XDH
23Adenosine monophosphate11 2412.1ADSL, HPRT1, PRPS1, APRT
245-methylthioadenosine4511.1APRT, PNP, ADSL
25probenecid45 29 60 50 1115.1XDH, SLC22A11, SLC22A12
26h2o24511.1S100A9, APRT, XDH, HPRT1, PNP
279-deazaguanine45 1112.1PNP, HPRT1
28Alpha-Phosphoribosylpyrophosphoric Acid1111.0APRT, HPRT1
298-azaguanine45 1112.0HPRT1, PNP
306-thiouric acid4511.0XDH, HPRT1
31febuxostat60 4512.0PNP, XDH
32benzbromarone4511.0SLC22A12, XDH
33aaph4511.0LCAT, XDH
344-hydroxynonenal45 2412.0ALDH2, XDH, LCAT
35pyrophosphate45 2412.0APRT, PRPS1, HPRT1, PNP
36ethyl methanesulfonate4511.0HPRT1, APRT
372,3-dideoxyadenosine4511.0IL1B, PNP
38pyrazinamide45 50 1113.0XDH, SLC22A12
39mercaptopurine50 1111.9XDH, HPRT1
40monosodium urate4510.9S100A9, IL1B
412-amino-3-methylimidazo(4,5-f)quinoline4510.9APRT, HPRT1
42calcium oxalate4510.9APRT, UMOD
43azathioprine45 50 2 1113.9PNP, HPRT1, XDH
44tiazofurin4510.9HPRT1
454-ipp6010.8S100A9, IL1B
46alpha tocopherol4510.7LCAT, XDH, ALDH2
47git 276010.7S100A9, IL1B
48deoxyadenosine45 2411.6PNP, APRT
49guanylate4510.6ALDH2, PNP, HPRT1
50didanosine45 1111.3PNP, HPRT1

GO Terms for genes affiliated with Gout

Sources:
16Gene Ontology
See all sources

Cellular components related to Gout according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:01632410.8SLC17A3, SLC22A12, SLC22A11, UMOD

Biological processes related to Gout according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:04428111.3LCAT, APRT, PRPS1, XDH, HPRT1, PNP
2purine nucleobase metabolic processGO:00614411.3ADSL, PNP, HPRT1, XDH, PRPS1, APRT
3nucleobase-containing small molecule metabolic processGO:05508611.2APRT, XDH, HPRT1, PNP, ADSL
4purine nucleotide biosynthetic processGO:00616411.0PRPS1, HPRT1, ADSL
5urate metabolic processGO:04641510.9SLC17A3, SLC22A12, SLC22A11
6purine-containing compound salvageGO:04310110.9PNP, HPRT1, APRT
7urate biosynthetic processGO:03441810.8PRPS1, PNP
8urate transportGO:01574710.8SLC22A12, SLC17A3
9adenine salvageGO:00616810.7APRT, HPRT1
10purine ribonucleoside salvageGO:00616610.6HPRT1, APRT
11grooming behaviorGO:00762510.6HPRT1, APRT
12organic anion transportGO:01571110.5SLC17A3, SLC22A11
13purine nucleotide catabolic processGO:00619510.3PNP, XDH

Molecular functions related to Gout according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1organic anion transmembrane transporter activityGO:00851410.6SLC17A3, SLC22A11
2urate transmembrane transporter activityGO:01514310.3SLC17A3, SLC22A12

Products for genes affiliated with Gout

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gout

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet