Gout malady

MedlinePlus: Gout is a common, painful form of arthritis. it causes swollen, red, hot and stiff joints. gout occurs when uric acid builds up in your blood. this happens if your body produces extra acid or does not eliminate enough, or if you eat too many foods with purines, such as liver and dried beans. pseudogout has similar symptoms and is sometimes confused with gout. however, it is caused by calcium phosphate, not uric acid. often, gout first attacks your big toe. it can also attack ankles, heels, knees, wrists, fingers and elbows. you are more likely to get gout if you are a man have family member with gout drink alcohol at first, gout attacks usually get better in days. eventually, attacks last longer and occur more often. uric acid buildup can lead to kidney stones. untreated gout can cause permanent joint and kidney damage. you can treat gout with medicines. nih: national institute of arthritis and musculoskeletal and skin diseases²³

MalaCards: Gout, also known as articular gout (disorder), is related to hyperuricemia and lesch-nyhan syndrome. An important gene associated with Gout is HPRT1 (hypoxanthine phosphoribosyltransferase 1), and among its related pathways are Translation Regulation activity of EIF4F and Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1. The drugs aspirin and gout suppressants and the compounds gtp and ionomycin have been mentioned in the context of this disorder. Affiliated tissues include joint, kidney and liver, and related mouse phenotypes are homeostasis/metabolism and hematopoietic system.

Disease Ontology: An arthritis that has material basis in uric acid crystal deposits located in joint.⁶

CDC: Gout is a rheumatic disease resulting from deposition of uric acid crystals (monosodium urate) in tissues and fluids within the body. This process is caused by an overproduction or under excretion of uric acid. Certain common medications, alcohol, and dietary foods are known to be contributory factors. Acute gout will typically manifest itself as an acutely red, hot, and swollen joint with excruciating pain. These acute gouty flare-ups respond well to treatment with oral anti-inflammatory medicines and may be prevented with medication and diet changes. Recurrent bouts of acute gout can lead to a degenerative form of chronic arthritis called gouty arthritis.²

Wikipedia: Gout (also known as podagra when it involves the big toe) is a medical condition usually characterized...⁴⁴ more...

Aliases & Descriptions:

gout 6 17 32 23 43 articular gout (disorder) 6 8 gouty arthropathy 6 arthritis, gouty 43

gouty arthritis 6 arthritis gouty 32

Diseases related to gout by text searches and GeneDecks gene sharing:

(show top 50)    (show all 815)

id	Related Disease	Score	Top Affiliating Genes
1	hyperuricemia	33.3	BCKDHA, UMOD, LEP, MTHFR, XDH, CD40LG
2	lesch-nyhan syndrome	32.7	XDH, APRT, MAOA, HPRT1, PNP, PRPS1
3	familial juvenile hyperuricemic nephropathy	30.8	UMOD, INS, HPRT1, HNF1B
4	gastric ulcer	28.7	INS, MET, IL1B, IL6, IL8, MAPK14
5	rheumatoid arthritis	28.2	IL1R1, HLA-DRB1, SRF, CRP, PRTN3
6	parkinson's disease	27.9	BLZF1, CHKB, BAX, MTR, INSR, APOE
7	rheumatoid vasculitis	27.7	SELE, IL1RAPL2, HLA-DRB1, TNF, SRF
8	werner syndrome	26.0	KAT2B, INS, INSR, IL6, APOE, MAPK14
9	vasculitis	25.3	SH2D4B, SELE, BLZF1, S100A9, CFP, CD79A
10	down syndrome	24.1	RAC1, LEP, BAX, MTHFR, MTR, XDH
11	insulin resistance	23.9	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, GCKR
12	arthritis	23.6	PIK3CG, KIT, BTK, SELE, BRAF, LPA
13	nephropathy	23.6	LRRC16A, SELE, LPA, MYD88, BLZF1, UMOD
14	osteoarthritis	23.5	PIK3CB, PIK3CG, LPA, BCL2, LEP, S100A9
15	blindness	22.6	PIK3CG, SELE, LEP, CHKB, MTHFR, XDH
16	prostatitis	18.8	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3C2B, PIK3CG
17	nephrolithiasis	14.3	UMOD, XDH, CDH1, INS, IL1B, APRT
18	hypouricemia	14.2	XDH, INS, ALB, HPRT1, PNP, SLC2A9
19	urolithiasis	14.1	UMOD, XDH, IL1B, IL6, APRT, ALB
20	bruton-type agammaglobulinemia	14.1	WAS, BTK, ITK, TEC, SRC, PLEK
21	lymphangioleiomyomatosis	14.0	MTOR, MLANA, SRF, RPS6, RPS6KB1, COMT
22	acquired immunodeficiency syndrome	14.0	MTR, XDH, CFP, FYN, IL1R1, IL6R
23	mental retardation syndrome	14.0	WASF1, RBX1, BRAF, MTOR, MTR, FGFR3
24	factor v leiden thrombophilia	14.0	PIK3CA, WAS, LPA, S100A9, XDH, CFP
25	immunodeficiency with hyper igm type 1	13.9	BTK, CD79A, CD40LG, IL4, HPRT1
26	malignant histiocytosis	13.9	IL1B, IL1R1, TNFRSF8, CRP, CSF1, CSF1R
27	chromophobe renal cell carcinoma	13.9	KIT, MET, MAGEA3, HNF1B, CTAG1B, KRT7
28	chronic pyelonephritis	13.8	LPXN, UMOD, CD79A, ALB, CALCA
29	lipoprotein lipase deficiency	13.8	LPA, LCAT, INS, APOA1, APOE, HP
30	skin benign neoplasm	13.8	BRAF, FGFR3, MAPK1, HPRT1, RPS6KB1, KRT20
31	chronic myelomonocytic leukemia	13.8	KIT, JAK2, PDGFRB, CSF1, CSF1R, CSF2
32	cherubism	13.8	FGFR3, CALCA, TNFSF11, SRC, SYK, CSF1
33	selective iga deficiency disease	13.7	BTK, CD79A, CD40LG, IL4
34	sm-ahnmd	13.7	KIT, JAK2, FGFR1, IL2RA, PDGFRB
35	hypereosinophilic syndrome	13.7	KIT, JAK2, FGFR1, IL2RA, SRF, PDGFRB
36	cystic kidney	13.7	UMOD, MAPK1, HNF1B, PKD1, PKD2, EGF
37	juvenile myelomonocytic leukemia	13.7	BRAF, RASA1, JAK2, CDKN3, CBL, PTEN
38	hematologic cancer	13.7	KIT, ZAP70, MTOR, JAK2, FGFR1, IL2RA
39	neurologic diseases	13.7	XDH, MPZ, IL1B, IL2RA, IL6, APOE
40	congestive heart failure	13.7	PIK3CG, GCA, CHKB, XDH, CDKN3, CORIN
41	thrombophilia	13.7	SELE, MTHFR, JAK2, ITGA3, FGR, APOE
42	tangier disease	13.7	LPA, RAC1, LCAT, ARF1, APOA1, APOE
43	synovial sarcoma	13.7	KIT, BCL2, CDH1, MET, MAGEA1, TNFRSF8
44	bronchitis	13.7	LEP, CHKB, MC4R, MAPK14, SRF, PPARA
45	cutaneous t cell lymphoma	13.7	SELE, BAX, IL2RA, IL4, IL7R, TNFRSF8
46	familial hypercholesterolemia	13.7	LPA, LCAT, APOA1, APOE, CBS, EGF
47	peripheral arterial occlusive disease	13.7	SELE, CD40LG, IL1B, IL6, GPT, HP
48	monoclonal gammopathy of undetermined significance	13.7	MPZ, CD79A, CD40LG, CDH1, IL1B, IL6
49	myelodysplastic syndrome	13.7	KIT, JAK2, FGFR1, HPRT1, TNFRSF10B, TNFSF10
50	splenomegaly	13.7	LCAT, JAK2, ITK, IL2RA, APOE, GPT

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 [ms400] antigout agents, acetylsalicylate sodium, aspirin, aspirin pwdr [va product], gout suppressants, ibuprofen, indomethacin, indomethacin pwdr [va product], indomethacin sodium, naproxen, naproxen sodium, probenecid, sulfinpyrazone, sulindac

MalaCards organs/tissues related to gout:

²²

FMA organs/tissues related to gout:

¹¹

MGI Mouse Phenotypes related to gout:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, NCK1
2	hematopoietic system phenotype	MP:0005397	10.8	PIM1, WAS, KIT, BTK, BRAF, MYD88
3	respiratory system phenotype	MP:0005388	10.4	PANX1, S1PR3, ITCH, INSR, APOE, CBL
4	other phenotype	MP:0005395	10.1	LAMA5, JAK2, CD40LG, ITGA6, APOE, PTGS2
5	renal/urinary system phenotype	MP:0005367	10.1	NCK1, WAS, KIT, BRAF, MYD88, BCL2
6	hearing/vestibular/ear phenotype	MP:0005377	10.1	KIT, MYD88, RASA1, PANX1, BCL2, BAX
7	liver/biliary system phenotype	MP:0005370	9.9	WASF1, WASF2, KIT, LCAT, BAG3, SAFB
8	craniofacial phenotype	MP:0005382	9.8	KIT, RASA1, LAMA5, MEN1, GRB2, MAP2K1
9	endocrine/exocrine gland phenotype	MP:0005379	9.7	WAS, SF1, XDH, CD40LG, ITGA3, FGFR1
10	integument phenotype	MP:0010771	9.7	PIK3C2B, PIK3CG, KIT, BTK, BRAF, RAC1
11	embryogenesis phenotype	MP:0005380	9.6	PIK3CB, PIK3CA, NCK1, NCKAP1, WASF2, KIT
12	pigmentation phenotype	MP:0001186	9.6	KIT, BRAF, RAC1, BCL2, LEP, S1PR2
13	no phenotypic analysis	MP:0003012	9.3	PIK3R1, PIK3C2B, MYD88, RASA1, BAG3, MTHFR
14	mortality/aging	MP:0010768	8.7	PIK3CB, PIK3CA, NCK1, NCKAP1, WASF1, WASF2
15	digestive/alimentary phenotype	MP:0005381	8.2	NCKAP1, WAS, WASF1, KIT, BTK, BRAF
16	vision/eye phenotype	MP:0005391	7.5	PIK3CA, KIT, SELE, BRAF, MYD88, BCL2
17	muscle phenotype	MP:0005369	7.4	PIK3CA, PIK3R2, PIK3R1, PIK3CG, WASF1, WASF2
18	reproductive system phenotype	MP:0005389	7.4	PIK3CA, SF1, BRK1, LEP, SAFB, S1PR2
19	cardiovascular system phenotype	MP:0005385	7.0	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, NCKAP1
20	tumorigenesis	MP:0002006	6.9	PIK3CB, PIK3CA, PIK3R2, PIK3R1, WAS, KIT
21	cellular phenotype	MP:0005384	6.6	PIK3CB, PIK3CA, PIK3R1, PIK3CG, PIM1, NCK1
22	skeleton phenotype	MP:0005390	INF	PIK3CG, WAS, KIT, BRAF, MYD88, UMOD
23	limbs/digits/tail phenotype	MP:0005371	INF	KIT, BTK, RAC1, RASA1, LEP, CHKB
24	growth/size phenotype	MP:0005378	INF	PIK3CB, PIK3CA, PIK3R1, PIK3CG, PIM1, NCK1
25	adipose tissue phenotype	MP:0005375	INF	PIK3CA, PIK3R1, BRAF, MYD88, BCL2, UMOD
26	immune system phenotype	MP:0005387	INF	WAS, KIT, BTK, BRAF, MYD88, PANX1
27	nervous system phenotype	MP:0003631	INF	NCK1, NCKAP1, WASF1, WASF2, KIT, BRAF
28	normal phenotype	MP:0002873	INF	PIK3R1, NCK1, SELE, BRAF, BIRC3, ZAP70
29	behavior/neurological phenotype	MP:0005386	INF	PIK3CA, NCK1, WASF1, KIT, SELE, BRAF

Articles related to gout:

(show top 50)    (show all 112)

id	Title	Authors	Year	Affiliating Genes
1	Urinary UMOD excretion and chronic kidney disease in gout patients: cross-sectional case-control study. (21332338)	Wu C.H.... Chen C.J.	2011	UMOD
2	Genome-wide association study for serum urate concent rations and gout among African Americans identifies genomic risk loci and a nov el URAT1 loss-of-function allele. (21768215)	Tin A.... KAPttgen A.	2011	PYGM, MEN1, MAP4K2
3	The genetic basis of hyperuricaemia and gout. (20472486)	Merriman T.R.... Dalbeth N.	2011	ABCG2, SLC2A9
4	Monoamine oxidase A gene polymorphisms and enzyme act ivity associated with risk of gout in Taiwan aborigines. (19915868)	Tu H.P.... Ko Y.C.	2010	COMT, MAOA
5	Urate-lowering therapy for gout: focus on febuxostat. (20500048)	Love B.L.... Snider K.M.	2010	XDH
6	The rs2231142 variant of the ABCG2 gene is associated with uric acid levels and gout among Japanese people. (20421215)	Yamagishi K.... Iso H.	2010	ABCG2
7	Management of hyperuricemia in gout: focus on febuxos tat. (20169038)	Reinders M.K.... Jansen T.L.	2010	XDH
8	The SLC22A12 gene is associated with gout in Han Chin ese and Solomon Islanders. (19762362)	Tu H.P.... Ko Y.C.	2010	SLC22A12
9	Effects of serial gout granules on insulin-resistanc e in primary gout patients (20214324)	Zhang M.... Wang Y.F.	2009	INSR, LEP
10	Adenine phosphoribosyltransferase deficiency in a Chinese man with early-onset gout. (19435978)	Chen C.J.... Schumacher H.R.	2009	APRT
11	Febuxostat (Uloric) for chronic treatment of gout. (19448587)		2009	XDH
12	Role of the urate transporter SLC2A9 gene in suscepti bility to gout in New Zealand MA8ori, Pacific Island, and Caucasian case-control sample sets. (19877038)	Hollis-Moffatt J.E.... Merriman T.R.	2009	SLC2A9
13	A sugar transporter regulates serum urate levels: imp lications for prevention and management of hyperuricemia in gout. (19296879)	Terkeltaub R.A.	2009	SLC2A6
14	Crystal-induced activation of the inflammasome: gout and pseudogout (19838718)	Winzer M.... Aringer M.	2009	XDH
15	High-resolution melting analysis for the rapid detect ion of an intronic single nucleotide polymorphism in SLC22A12 in male patients with primary gout in China. (19306160)	Guan M.... Zou H.	2009	SLC22A12
16	Febuxostat: a selective xanthine-oxidase/xanthine-deh ydrogenase inhibitor for the management of hyperuricemia in adults with gout. (20109996)	Ernst M.E.... Fravel M.A.	2009	XDH
17	Crystal ball gazing: new therapeutic targets for hyperuricaemia and gout. (19109320)	Dalbeth N.... Merriman T.	2009	IL1B, SLC22A12
18	Common defects of ABCG2, a high-capacity urate export er, cause gout: a function-based genetic analysis in a Japanese population. (20368174)	Matsuo H.... Shinomiya N.	2009	ABCG2
19	New aspects of the pathogenesis of gout. Danger signals, autoinflammation and beyond (18299853)	Lamprecht P.... Kabelitz D.	2008	PRTN3
20	Anti-gout agent allopurinol exerts cytotoxicity to human hormone-refractory prostate cancer cells in combination with tumor necrosis factor-related apoptosis-inducing ligand. (19074830)	Yasuda T.... Sakai T.	2008	TNFRSF10B, TNFSF10
21	Historical review of gout and hyperuricemia investigations (18409506)	Nakamura T.	2008	UMOD
22	Associations between gout tophus and polymorphisms 869T/C and -509C/T in transforming growth factor beta1 gene. (18356176)	Chang S.J.... Ko Y.C.	2008	TGFB1
23	Pharmacological basis for use of Pistacia integerrima leaves in hyperuricemia and gout. (18420362)	Ahmad N.S.... Hasan A.	2008	XDH
24	Association of common polymorphisms in GLUT9 gene with gout but not with coronary artery disease in a large case-control study. (18398472)	Stark K.... Hengstenberg C.	2008	SLC2A9
25	Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. (18834626)	Dehghan A.... Fox C.S.	2008	ABCG2, SLC2A9, SLC17A3
26	Probenecid, a gout remedy, inhibits pannexin 1 channels. (18596212)	Silverman W.... Dahl G.	2008	PANX1
27	Relationship between insulin resistance and low urinary pH in patients with gout, and effects of PPARalpha agonists on urine pH. (17611904)	Takahashi S.... Yamamoto T.	2007	PPARA
28	Colchicine prescribing and safety monitoring in patients with gout. (18264188)	Ly J.... Dalbeth N.	2007	CHKB
29	Tumor necrosis factor-alpha and interleukin-4 gene polymorphisms in Chinese patients with gout. (17631734)	Chen M.L.... Huang C.M.	2007	TNF, IL4
30	Emerging therapies in the long-term management of hyperuricaemia and gout. (17388867)	Stamp L.K.... Chapman P.T.	2007	XDH
31	HPRT deficiency in a two-month-old child presenting acute renal failure and gout with a new deletion of two bases in exon 3 of the HPRT gene. (17416296)	Zamora A.... O'Neill J.P.	2007	HPRT1
32	Recent developments in diet and gout. (16462528)	Lee S.J.... Kavanaugh A.	2006	INS
33	Newer therapeutic approaches: gout. (16504833)	Schumacher H.R.... Chen L.X.	2006	XDH
34	Pathogenesis, clinical findings and management of acute and chronic gout. (17213786)	Corrado A.... Cantatore F.P.	2006	XDH
35	Markers of vascular endothelium activation in gout (15989007)	Lapkina N.A.... Iakunina I.A.	2005	CRP
36	Interleukin-1beta gene polymorphisms in Taiwanese patients with gout. (14661113)	Chen M.L.... Tsai F.J.	2005	IL1B
37	Normal HPRT coding region in a male with gout due to HPRT deficiency. (15862284)	Dawson P.A.... Emmerson B.T.	2005	HPRT1
38	Contribution of polymorphisms in the apolipoprotein AI-CIII-AIV cluster to hyperlipidaemia in patients with gout. (15115711)	Cardona F.... Soriguer F.J.	2005	APOA1, INS
39	Genomewide scan for gout in taiwanese aborigines reveals linkage to chromosome 4q25. (15252757)	Cheng L.S.... Ko Y.C.	2004	ABCG2
40	A literature review of the epidemiology and treatment of acute gout. (12860487)	Kim K.Y.... Kong S.X.	2003	PTGS2
41	Corticotropin for acute management of gout. (11261536)	Taylor C.T.... Kelley K.W.	2001	POMC
42	Reduced secretion of proinflammatory cytokines of monosodium urate crystal-stimulated monocytes in chronic renal failure: an explanation for infrequent gout episodes in chronic renal failure patients? (10809805)	Schreiner O.... MAorker-Hermann E.	2000	IL1B
43	How should we treat tophaceous gout in patients with allopurinol hypersensitivity? (9598024)	Grahame R.... Marsh F.P.	1998	HPRT1
44	Uric acid crystals and chemotactic cytokines--pathogenesis of an acute gout attack (9446414)	Peichl P.	1997	IL8
45	Omeprazole, other antiulcer drugs and newly diagnosed gout. (9278205)	Meier C.R.... Jick H.	1997	HRH2
46	Gout, uric acid metabolism, and crystal-induced inflammation. (7547116)	Weinberger A.	1995	IL8, SELE, CSF2
47	Hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency: identification of point mutations in Japanese patients with Lesch-Nyhan syndrome and hereditary gout and their permanent expression in an HPRT-deficient mouse cell line. (8112742)	Tohyama J.... Ohno K.	1994	HPRT1
48	Excess release of hypoxanthine from exercising muscle in two gout patients with partial HGPRTase deficiency: lack of ammonium release. (2012099)	Hisatome I.... Takeda A.	1991	HPRT1
49	Human hypoxanthine-guanine phosphoribosyltransferase. Structural alteration in a dysfunctional enzyme variant (HPRTMunich) isolated from a patient with gout. (6706936)	Wilson J.M.... Kelley W.N.	1984	HPRT1
50	Human hypoxanthine (guanine) phosphoribosyltransferase: an amino acid substitution in a mutant form of the enzyme isolated from a patient with gout. (6572373)	Wilson J.M.... Kelley W.N.	1983	HPRT1

Genes related to gout according to GeneCards:

(show top 50)    (show all 261)

id	Symbol	Description	Score	GeneCards Section Context
1	HPRT1	hypoxanthine phosphoribosyltransferase 1	11.1	Summaries, Publications
2	UMOD	uromodulin	11.1	Publications, Summaries
3	SLC22A12	solute carrier family 22 (organic anion/urate transporter), member 12	11.0	Summaries, Publications
4	UAQTL4	Uric acid concentration, serum, QTL4	11.0	Aliases & Descriptions
5	UAQTL3	Uric acid concentration, serum, QTL3	11.0	Aliases & Descriptions
6	PRPS1	phosphoribosyl pyrophosphate synthetase 1	11.0
7	ADSL	adenylosuccinate lyase	11.0	Publications
8	SLC2A9	solute carrier family 2 (facilitated glucose transporter), member 9	11.0	UniProt Related, Publications
9	APRT	adenine phosphoribosyltransferase	11.0	Publications
10	XDH	xanthine dehydrogenase	11.0	Publications
11	LCAT	lecithin-cholesterol acyltransferase	11.0
12	HNF1B	HNF1 homeobox B	11.0
13	PNP	purine nucleoside phosphorylase	11.0
14	ALDH2	aldehyde dehydrogenase 2 family (mitochondrial)	11.0	Publications
15	S100A9	S100 calcium binding protein A9	11.0
16	IL1B	interleukin 1, beta	11.0	Publications
17	LOC100291666	serologically defined breast cancer antigen NY-BR-40	10.9	Publications
18	GDI2P1	GDP dissociation inhibitor 2 pseudogene 1	10.9	Publications
19	COASY	CoA synthase	10.9	Publications
20	BRK1	BRICK1, SCAR/WAVE actin-nucleating complex subunit	10.9	Publications
21	INHBC	inhibin, beta C	10.9	Publications
22	TMPRSS5	transmembrane protease, serine 5	10.9	Publications
23	CALML4	calmodulin-like 4	10.9	Publications
24	MRPS26	mitochondrial ribosomal protein S26	10.9	Publications
25	SLC22A11	solute carrier family 22 (organic anion/urate transporter), member 11	10.9	Publications
26	SP9	Sp9 transcription factor homolog (mouse)	10.9	Disorders
27	SLC2A6	solute carrier family 2 (facilitated glucose transporter), member 6	10.9	Publications
28	ARHGEF25	Rho guanine nucleotide exchange factor (GEF) 25	10.9	Publications
29	SLC17A2	solute carrier family 17 (sodium phosphate), member 2	10.9	Publications
30	GCA	grancalcin, EF-hand calcium binding protein	10.9	Publications
31	FCN3	ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)	10.9	Publications
32	FCN1	ficolin (collagen/fibrinogen domain containing) 1	10.9	Publications
33	ERGIC3	ERGIC and golgi 3	10.9	Publications
34	GLUD2	glutamate dehydrogenase 2	10.9	Publications
35	SLC17A3	solute carrier family 17 (sodium phosphate), member 3	10.9	Publications
36	ARF3	ADP-ribosylation factor 3	10.9	Publications
37	PDZK1	PDZ domain containing 1	10.9	Publications
38	NDUFB8	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa	10.9
39	SLC17A1	solute carrier family 17 (sodium phosphate), member 1	10.9	Publications
40	PRAME	preferentially expressed antigen in melanoma	10.9	Publications
41	S1PR3	sphingosine-1-phosphate receptor 3	10.9	Publications
42	SGOL1	shugoshin-like 1 (S. pombe)	10.9	Publications
43	PRKACG	protein kinase, cAMP-dependent, catalytic, gamma	10.9	Publications
44	GCKR	glucokinase (hexokinase 4) regulator	10.9	Publications
45	SLC34A2	solute carrier family 34 (sodium phosphate), member 2	10.9	Publications
46	HPN	hepsin	10.9	Publications
47	PPIL4	peptidylprolyl isomerase (cyclophilin)-like 4	10.9	Publications
48	FCN2	ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)	10.9	Publications
49	TMPRSS3	transmembrane protease, serine 3	10.9	Publications
50	EFS	embryonal Fyn-associated substrate	10.9	Publications

Pathways related to gout according to GeneDecks:

(show top 50)    (show all 430)

id	Pathway	Score	Top Affiliating Genes
1	Translation Regulation activity of EIF4F10	11.0	RHEB, PDPK1, PIK3R2, PIK3CB
2	Apoptosis and survival Anti-apoptotic action of membrane-bound ESR110	10.9	PIK3R2
3	Development EGFR signaling pathway10	10.8	CBL
4	Bacterial invasion of epithelial cells20	10.6	DNM1, DNM3, SHC1, CBL, RAC1, SEPT1
5	Cell adhesion PLAU signaling10	10.6	PIK3CB, PIK3CA, PIK3R2, PIK3R1, CSNK2B, CSNK2A1
6	ErbB2-ErbB3 Heterodimers36	10.4	PIK3R2, PRKCE, STAT1, PDPK1, RPS6KB1, PLCG1
7	Development_IGF-1 receptor signaling41	10.3	RPS6KB1, RPS6, PTEN, MAP2K1, MAPK1, MAPK3
8	Development IGF-RI signaling10	10.3	SHC1, RHEB, PDPK1, RPS6KA1, RPS6KB1, RPS6
9	Transcription PPAR Pathway10	10.2	PIK3CA, PIK3CB, PIK3R2, PRKACG, SHC1, PDGFRB
10	Development_Endothelin-1/EDNRA transactivation of EGFR41	10.2	SRC, MAP2K1, MAPK1, MAPK3, GRB2, MTOR
11	Sorafenib Pharmacodynamics34	10.2	PDGFRB, MAP2K1, MAPK1, MAPK3, BRAF, PIK3C2B
12	Development_FGFR signaling pathway41	10.2	PDPK1, PIK3CB, PIK3CA, PLCG1, CBL, MAP2K1
13	Immune response BCR pathway10	10.1	PIK3R1, PIK3R2, PIK3CA, PIK3CB, BTK, RAC1
14	Transcription_Receptor-mediated HIF regulation41	10.1	INSR, INS, MTOR, PIK3R1, PIK3R2, PIK3CA
15	mTOR signaling pathway20	10.1	RPS6, MAPK1, MAPK3, INS, MTOR, BRAF
16	Development_HGF signaling pathway41	10.1	PDPK1, PLCG1, MAP2K1, MAPK1, MAPK3, GRB2
17	Prolactin Signaling36	10.0	PIK3R2, BRAF, FYN, EP300, PRLR, PRKCE
18	Translation Regulation activity of EIF210	10.0	MAPK3, GRB2, INSR, PIK3R1, PIK3R2, PIK3CA
19	Development_Flt3 signaling41	10.0	SHC1, PDPK1, RPS6KA1, RPS6KA2, CBL, MAP2K1
20	Translation_Insulin regulation of translation41	10.0	SHC1, PIK3CB, PIK3R2, PIK3R1, MTOR, RHEB
21	Fc gamma R-mediated phagocytosis20	10.0	WASF1, WAS, PIK3CG, PIK3R1, PIK3R2, PIK3CA
22	Development_VEGF signaling via VEGFR2 - generic cascades41	9.9	PRKCE, SHC1, PDPK1, PIK3CB, PIK3CA, PLCG1
23	Immune response_BCR pathway41	9.9	LYN, SYK, SHC1, PDPK1, RPS6KB1, PLCG1
24	Development_Ligand-independent activation of ESR1 and ESR241	9.9	EP300, ADRB3, PRKACG, EGF, SHC1, PDPK1
25	Signal transduction PTEN pathway10	9.9	EGF, SHC1, RHEB, PDPK1, SRC, PTEN
26	Development EGFR signaling via small GTPases10	9.9	EGF, SHC1, ERBB2, CBL, MAP2K1, MAPK1
27	Regulation of lipid metabolism_Insulin signaling-generic cascades41	9.8	PIK3CB, RPS6KA1, RPS6KB1, RPS6, MAP2K1, MAPK1
28	Glioma20	9.8	EGF, SHC1, PDGFRB, PIK3CB, PLCG1, PTEN
29	Development_EGFR signaling pathway41	9.7	STAT1, EGF, SHC1, PDPK1, PLCG1, SRC
30	Development_CNTF receptor signaling41	9.6	MAPK1, MAPK3, GRB2, JAK2, MTOR, PIK3R1
31	Development_Prolactin receptor signaling41	9.5	MAPK1, MAPK3, GRB2, JAK2, FYN, BCL2
32	Transcription_PPAR Pathway41	9.5	PIK3R2, PIK3CA, PIK3CB, PIK3R1, INSR, GRB2
33	Development Prolactin receptor signaling10	9.5	JAK2, FYN, BCL2, RAC1, PIK3R1, PIK3R2
34	Endometrial cancer20	9.5	ERBB2, MAP2K1, MAPK1, MAPK3, GRB2, CDH1
35	ErbB signaling pathway20	9.4	SRC, ERBB2, CBL, MAP2K1, MAPK1, MAPK3
36	Insulin signaling pathway20	9.4	RPS6KB1, RPS6, PYGM, CBL, MAP2K1, MAPK1
37	Endothelin-1 Signaling Pathway36	9.3	ERBB2, MAPK1, MAPK3, IL6, IL4, IL1B
38	14-3-3 Induced Intracellular Signaling36	9.2	CSF1R, GRB2, FGFR3, INSR, PIK3R1, PIK3R2
39	Prostate cancer20	9.0	MAPK3, GRB2, FGFR1, INS, MTOR, BCL2
40	Cytokine-cytokine receptor interaction20	8.9	CSF2, IL6, IL4, IL2RA, IL1R1, IL1B
41	ERK Signaling36	8.8	SRF, SRC, TNFSF11, TNFSF10, ERBB2, MAP2K1
42	p70S6K Signaling36	8.3	EGF, PDPK1, PDGFRB, RPS6KB1, PLCG1, NRP1
43	Tec Kinases Signaling36	8.3	PDGFRB, MET, FGFR3, FGFR1, INSR, ITK
44	TGF-Beta Pathway36	8.3	EP300, TGFB1, EGF, PPP2R4, TNFSF10, FGFR3
45	Antioxidant Action of Vitamin-C36	8.3	FGFR1, JAK2, BAX, BCL2, RAC1, BTK
46	Pancreatic Adenocarcinoma36	8.3	CSF1R, STAT1, TGFB1, EGF, PDGFRB, SRC
47	Molecular Mechanisms of Cancer36	8.2	CSF1R, IL6R, IL6, IL1R1, GRB2, MET
48	p38 Signaling36	8.0	CSF2, CSF1R, CSF1, PRKCE, STAT1, TGFB1
49	JAK-STAT Pathway36	7.8	PSMC6, STAT1, TGFB1, EGF, PDGFRB, SP1
50	MAPK Family Pathway36	7.7	GRB2, MET, FGFR3, FGFR1, ARHGEF11, BAX

Compounds related to gout according to GeneDecks:

(show top 50)    (show all 407)

id	Compound	Score	Top Affiliating Genes
1	gtp32	11.2	PIK3CA, PIK3R1, WAS, BRAF, RAC1, RASA1
2	ionomycin32	10.7	PIK3CB, PIM1, WAS, BTK, FYN, IL7R
3	glucose32	10.3	KIT, BRAF, UMOD, SAFB, XPO1, FGFR1
4	egcg32	10.2	PIK3CG, MAPK3, MAPK14, MAP2K1, SP1, PLCG1
5	gp 13032	10.2	PIK3R1, PIM1, KIT, BTK, JAK2, IL1R1
6	nitric oxide32 9 18 9	13.0	PIK3CB, KIT, SELE, LPA, MYD88, CHKB
7	hyaluronic acid32 18	11.0	RAC1, CDH1, GPT, PTEN, NRP1, PNP
8	aspartate32	9.9	PIK3R1, BRAF, CHKB, MPZ, CD40LG, CDH1
9	calcitriol32 42 9 18 9	13.9	PIK3CB, XPO1, S100A9, CDH1, FGR, IL2RA
10	vitamin b1232	9.9	LPA, MTHFR, MTR, CD79A, CD40LG, APOA1
11	vanadate32	9.8	NCK1, BLZF1, FYN, JAK2, CDKN3, INSR
12	epinephrine32 9 18 9	12.7	SELE, LEP, CHKB, JAK2, CD79A, INS
13	cysteine32	9.7	BTK, LPA, RAC1, BLZF1, UMOD, CHKB
14	progesterone32 42 9 18 9	13.6	PIK3CA, PIK3R1, KIT, BRAF, BCL2, KAT2B
15	pge232	9.5	SELE, RAC1, CDH1, IL1R1, IL1RAPL2, APOA1
16	fmlp32	9.5	PIK3CG, RAC1, S100A9, ARF1, FGR, IL1B
17	acetylcholine32 9 18 9	12.4	RAC1, BLZF1, LEP, CD79A, CD40LG, CDKN3
18	okadaic acid32 42	10.4	PIK3CA, PIK3R1, GCA, BLZF1, BCL2, MTOR
19	formaldehyde32 18	10.4	KIT, SELE, BLZF1, ZAP70, CD79A, CD40LG
20	atp32	9.3	PIK3CB, PIK3CA, PIM1, WAS, KIT, KIF2C
21	erlotinib32 34 9 9	12.2	PIK3CA, KIT, MTOR, CDKN3, CDH1, MAPK1
22	rituximab32 34 9 9	12.2	BCL2, ZAP70, MTOR, CD79A, CD40LG, IL1R1
23	adp32 18	10.0	PIK3CB, PIK3CA, PIK3C2B, PIK3CG, PIM1, COASY
24	phosphotyrosine32	9.0	PIK3CB, PIK3CA, PIK3R1, PIK3C2B, PIK3CG, SH2D4B
25	resveratrol32 9 18 9	11.9	PIK3CA, PIK3CG, BCL2, BAX, MTOR, XDH
26	arachidonic acid32 9 18 9	11.9	PIK3CA, RAC1, RASA1, MTOR, S100A9, JAK2
27	neopterin32	8.9	CHKB, CD79A, CD40LG, IL1B, IL1R1, IL1RAPL2
28	thapsigargin32 42	9.9	PIK3CG, BTK, BLZF1, BCL2, CDKN3, IL4
29	arsenite32 18	9.8	PIK3CA, PIK3R1, PIK3CG, RAC1, BCL2, BAX
30	imatinib32 34 9 9	11.8	PIK3CA, PIK3R1, PIK3CG, KIT, BRAF, BCL2
31	cholesterol32 9 18 9	11.8	PIK3CB, PIK3CA, PIK3R1, SELE, LPA, LPXN
32	norepinephrine32 9 18 9	11.7	SELE, LEP, CHKB, CD79A, CD40LG, INS
33	alanine32	8.7	PIM1, SELE, BRAF, RASA1, BLZF1, BIRC3
34	phosphoinositide32	8.6	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3C2B, PIK3CG
35	testosterone32 9 18 9	11.6	PIK3CA, PIK3R1, KIT, SELE, BLZF1, CHKB
36	phosphatidylinositol32	8.5	PIK3CB, PIK3CA, PIK3R2, PIK3R1, PIK3CG, SH2D4B
37	pdtc32	8.3	PIK3CA, PIK3CG, SELE, BIRC3, BCL2, XDH
38	tamoxifen32 34 9 9	11.3	PIK3CA, SELE, BCL2, LEP, CHKB, BAX
39	paclitaxel32 34 9 9	11.2	PIK3CA, PIK3CG, KIT, BRAF, RAC1, BIRC3
40	methotrexate32 34 42 9 9	12.2	KIT, SELE, LEP, CHKB, MTHFR, MTR
41	curcumin32	8.0	PIK3CG, BIRC3, BCL2, BAX, KAT2B, MPZ
42	thymidine32 18	8.9	PIK3CA, PIK3R1, KIT, RAC1, CHKB, ZAP70
43	indomethacin32 9 9	9.3	LEP, JAK2, CD79A, CD40LG, CDKN3, CDH1
44	vitamin d32	7.3	CHKB, MTHFR, SAFB, CD79A, CDH1, INSR
45	pd 98,05932	6.9	PIK3CA, PIK3R1, PIK3CG, KIT, BRAF, RAC1
46	dexamethasone32 42 34 9 9	10.5	PIK3CA, PIK3R1, BIRC3, BCL2, LEP, CHKB
47	heparin32 9 18 9	INF	PIK3CA, PIK3CG, LPA, UMOD, CHKB, ZAP70
48	aspirin32 34 18	INF	SELE, LPA, CHKB, MTHFR, JAK2, CD79A
49	cyclic amp32 18	INF	PIK3R1, BRAF, S1PR1, FYN, CDH1, FGR
50	calcium32 9 18 9	INF	PIK3C2B, PIM1, SH2D4B, WAS, KIT, GCA

Cellular components related to gout according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:005886	INF	ADRB3, ADCY10, LYN, NEDD4, SLC17A1,
2	perinuclear region of cytoplasm	GO:048471	9.7	TF, DNM3, PRKCE, CSF1, SLC17A3, NEDD4
3	caveola	GO:005901	9.6	PTGS2, MAPK1, MAPK3, INSR, JAK2, SELE
4	cytoplasm	GO:005737	9.1	PLCG1, PNP, PPP2R4, PPP1R14C, PLEK, RPS6
5	cytosol	GO:005829	8.1	IL1B, XDH, XPO1, MTR, MTHFR, MTOR
6	extracellular region	GO:005576	INF	CORIN, PLEK, CRP, NRP1, SVEP1, PTX3
7	integral to plasma membrane	GO:005887	INF	CSF1R, PDGFRB, PKD2, PKD1, CORIN, TMPRSS2
8	extracellular space	GO:005615	INF	TNF, HP, CALCA, , ALB, APOE

Biological processes related to gout according to GeneDecks:

(show top 50)    (show all 77)

id	Name	GO ID	Score	Top Affiliating Genes
1	urate metabolic process	GO:046415	11.4	SLC17A1, SLC22A12, SLC22A11, SLC2A9, SLC17A3, SLC16A9
2	phosphatidylinositol biosynthetic process	GO:006661	10.6	PTEN, ARF3, ARF1, PIK3CG, PIK3C2B, PIK3R1
3	leukocyte migration	GO:050900	10.6	SRC, PLCG1, SHC1, SLC7A11, LYN, GRB2
4	T cell receptor signaling pathway	GO:050852	10.5	ITK, HLA-DRB1, PTEN, PLCG1, PDPK1, CSK
5	phosphatidylinositol-mediated signaling	GO:048015	10.5	PTEN, RPS6KB1, RPS6KB2, PDGFRB, PDPK1, CSF1R
6	protein kinase B signaling cascade	GO:043491	10.4	EP300, TGFB1, RPS6KB2, RPS6KB1, PTEN, TNF
7	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	10.4	NEDD4, PDGFRB, CBL, FGR, FGFR1, INS
8	T cell costimulation	GO:031295	10.3	LYN, CSK, PDPK1, SRC, HLA-DRB1, GRB2
9	positive regulation of phosphatidylinositol 3-kinase activity	GO:043552	10.3	LYN, TGFB1, PDGFRB, FGR, FGFR3, RAC1
10	insulin receptor signaling pathway	GO:008286	10.2	MAPK1, MAP2K1, RPS6, RPS6KB1, PDPK1, RHEB
11	peptidyl-tyrosine phosphorylation	GO:018108	10.2	LYN, KIT, BTK, ZAP70, FYN, CSF1R
12	positive regulation of smooth muscle cell proliferation	GO:048661	10.2	STAT1, SHC1, PDGFRB, RPS6KB1, PTGS2, TNF
13	JAK-STAT cascade involved in growth hormone signaling pathway	GO:060397	10.2	MAPK3, MAPK1, STAT1, PRLR, PRL, LYN
14	positive regulation of nitric oxide biosynthetic process	GO:045429	10.2	PKD2, PTX3, PTGS2, TNF, HSP90AA1, IL1B
15	positive regulation of tyrosine phosphorylation of Stat3 protein	GO:042517	10.2	CSF1R, KIT, LEP, JAK2, FGFR3, IL6
16	small molecule metabolic process	GO:044281	10.1	PPARA, PTGS2, PTEN, PYGM, HPRT1, HSP90AA1
17	response to glucocorticoid stimulus	GO:051384	10.1	RPS6KB1, SHC1, ADM, EP300, PTGS2, TNF
18	nerve growth factor receptor signaling pathway	GO:048011	10.1	PRKCE, SHC1, PDPK1, RPS6KB2, RPS6KA1, RPS6KA2
19	lipopolysaccharide-mediated signaling pathway	GO:031663	10.0	LYN, PRKCE, STAT1, TGFB1, TNF, MAPK14
20	positive regulation of cell migration	GO:030335	10.0	LYN, CSF1R, CSF1, TGFB1, PDGFRB, MAP2K1
21	fibroblast growth factor receptor signaling pathway	GO:008543	10.0	PRKACG, PRKCE, SHC1, PDPK1, RPS6KB2, PLCG1
22	regulation of inflammatory response	GO:050727	10.0	MYD88, BIRC3, JAK2, CALCA, PTGS2, LYN
23	protein autophosphorylation	GO:046777	10.0	MAPK14, ERBB2, PDGFRB, PDPK1, SYK, CSF1R
24	toll-like receptor 1 signaling pathway	GO:034130	10.0	RPS6KA1, RPS6KA2, MAP2K1, MAPK1, MAPK14, MAPK3
25	negative regulation of epidermal growth factor receptor signaling pathway	GO:042059	9.9	EGF, UBC, GRB2, AP2A1, AP2A2, CBL
26	activation of MAPK activity	GO:000187	9.9	MAPK14, MAPK1, MAP2K1, TNF, SHC1, MAPK3
27	toll-like receptor 2 signaling pathway	GO:034134	9.9	RPS6KA2, MAP2K1, MAPK1, MAPK14, MAPK3, UBC
28	axon guidance	GO:007411	9.9	HSP90AA1, ERBB2, TRIO, SRC, NRP1, PLCG1
29	positive regulation of MAPK cascade	GO:043410	9.9	ADRB3, PRKCE, IL6R, IL6, FGFR3, FGFR1
30	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.8	EP300, SRF, PTEN, TNFSF11, TNF, IL6
31	positive regulation of mitosis	GO:045840	9.8	EGF, PDGFRB, TNF, IL1B, MET, INSR
32	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.8	TGFB1, TNFSF11, TNFRSF8, TNF, IL6R, IL6
33	virus-host interaction	GO:019048	9.7	SP1, PLCG1, KRT7, TGFB1, SYK, STAT1
34	positive regulation of MAP kinase activity	GO:043406	9.6	TGFB1, EGF, PDGFRB, TNFSF11, TNF, ERBB2
35	intracellular protein kinase cascade	GO:007243	9.5	PRKACG, RPS6KA2, SRC, TEC, MAP4K2, MAPK14
36	apoptotic process	GO:006915	9.5	TNFSF10, TNFRSF10B, TNF, TRIO, MAPK1, MAPK14
37	positive regulation of cell proliferation	GO:008284	9.4	PRAME, TGFB1, EGF, SHC1, PRTN3, CSF1
38	epidermal growth factor receptor signaling pathway	GO:007173	9.4	MAPK1, MAPK3, AP2A2, AP2A1, GRB2, MTOR
39	signal transduction	GO:007165	9.4	WWP1, RHEB, PDGFRB, RPS6KB2, RPS6KA1, RPS6KA2
40	negative regulation of apoptotic process	GO:043066	9.3	CBL, HPN, HNF1B, TNF, PTEN, RPS6KB1
41	inflammatory response	GO:006954	9.3	IL8, CALCA, TNF, PTGS2, PTX3, CRP
42	response to drug	GO:042493	9.2	RPS6KB1, COMT, ABCG2, TGFB1, SLC22A12, LYN
43	protein phosphorylation	GO:006468	9.1	TEC, RPS6KB1, PDPK1, TGFB1, SYK, STRADA
44	MAPK cascade	GO:000165	9.0	TGFB1, SHC1, TNF, MAP2K1, MAPK1, MAPK3
45	response to hypoxia	GO:001666	8.9	SHC1, TGFB1, ADSL, ADM, EP300, CRP
46	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.8	PPARA, SP1, SRF, TNFSF11, TNF, RPS6KA1
47	negative regulation of cell proliferation	GO:008285	8.7	PTGS2, SRF, RPS6KA2, PKD2, TGFB1, CSK
48	platelet activation	GO:030168	8.3	TGFB1, EGF, SHC1, PDPK1, PLEK, SRF
49	innate immune response	GO:045087	INF	, IFIH1, MAP2K1, MAP4K2, MAPK1, RPS6KA2
50	blood coagulation	GO:007596	INF	PIK3R2, PIK3CA, PIK3CB, LYN, SLC7A11, CSK

Molecular functions related to gout according to GeneDecks:

(show all 16)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	SLC22A11, CST3, CSNK2B, CSNK2A1, CSK, CSF2
2	receptor binding	GO:005102	10.7	PPP2R4, PKD2, PDGFRB, CSNK2B, POMC, ADM
3	phosphotyrosine binding	GO:001784	10.6	SHC1, CBL, MAPK3, GRB2, FGR, ZAP70
4	non-membrane spanning protein tyrosine kinase activity	GO:004715	10.5	LYN, CSK, SYK, SRC, TEC, FGR
5	insulin receptor substrate binding	GO:043560	10.4	GRB2, INSR, JAK2, PIK3R1, PIK3CA, PIK3CB
6	ephrin receptor binding	GO:046875	10.2	SHC1, SRC, CBL, GRB2, FYN, PIK3CG
7	neurotrophin TRKA receptor binding	GO:005168	10.2	SHC1, PLCG1, GRB2, PIK3R1
8	receptor signaling protein tyrosine kinase activity	GO:004716	10.1	LYN, SYK, ERBB2, INSR, KIT
9	protein domain specific binding	GO:019904	10.0	EFS, NEDD4, CSNK2B, SYK, PKD1, PPARA
10	protein tyrosine kinase activity	GO:004713	9.9	MAP2K1, ERBB2, SRC, PDGFRB, SHC1, CSK
11	protein homodimerization activity	GO:042803	9.8	SP1, PPP2R4, CRP, PLEK, PKD2, ABCG2
12	lipid binding	GO:008289	9.7	PPARA, PTGS2, PTEN, APOE, AP2A2, S1PR3
13	identical protein binding	GO:042802	9.7	HSP90AA1, ERBB2, TNF, PKD2, ZNHIT6, DNM1
14	protease binding	GO:002020	9.5	TNF, IL1R1, INS, UBC, BCL2, KIT
15	protein serine/threonine kinase activity	GO:004674	9.3	RPS6KA2, RPS6KA1, RPS6KB2, PDPK1, STRADA, CSNK2A1
16	ATP binding	GO:005524	8.9	COASY, PIM1, PIK3CG, PIK3C2B, PIK3CA, PIK3CB