MCID: GT001
MIFTS: 56

Gout malady

Genetic diseases (common), Bone diseases categories

Aliases & Classifications for Gout

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Summaries for Gout

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MedlinePlus:32 Gout is a common, painful form of arthritis. it causes swollen, red, hot and stiff joints. gout happens when uric acid builds up in your body. uric acid comes from the breakdown of substances called purines. purines are in your body's tissues and in foods, such as liver, dried beans and peas, and anchovies. normally, uric acid dissolves in the blood. it passes through the kidneys and out of the body in urine. but sometimes uric acid can build up and form needle-like crystals. when they form in your joints, it is very painful. the crystals can also cause kidney stones. often, gout first attacks your big toe. it can also attack ankles, heels, knees, wrists, fingers, and elbows. at first, gout attacks usually get better in days. eventually, attacks last longer and happen more often. you are more likely to get gout if you are a man have family member with gout are overweight drink alcohol eat too many foods rich in purines gout can be hard to diagnose. your doctor may take a sample of fluid from an inflamed joint to look for crystals. you can treat gout with medicines. pseudogout has similar symptoms and is sometimes confused with gout. however, it is caused by calcium phosphate, not uric acid. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Gout, also known as gouty arthropathy, is related to phosphoribosylpyrophosphate synthetase superactivity and hprt-related gout. An important gene associated with Gout is HPRT1 (hypoxanthine phosphoribosyltransferase 1), and among its related pathways are One carbon pool by folate and purine nucleotide salvage. The drugs allopurinol and aspirin and the compounds ethyl methanesulfonate and 2-amino-3-methylimidazo(4,5-f)quinoline have been mentioned in the context of this disorder. Affiliated tissues include joint, kidney and liver, and related mouse phenotypes are hematopoietic system and renal/urinary system.

Disease Ontology:9 An arthritis that has material basis in uric acid crystal deposits located in joint.

CDC:3 Gout is a rheumatic disease resulting from deposition of uric acid crystals (monosodium urate) in tissues and fluids within the body. This process is caused by an overproduction or under excretion of uric acid. Certain common medications, alcohol, and dietary foods are known to be contributory factors. Acute gout will typically manifest itself as an acutely red, hot, and swollen joint with excruciating pain. These acute gouty flare-ups respond well to treatment with oral anti-inflammatory medicines and may be prevented with medication and diet changes. Recurrent bouts of acute gout can lead to a degenerative form of chronic arthritis called gouty arthritis.

Wikipedia:63 Gout (also known as podagra when it involves the big toe) is a medical condition usually characterized... more...

Related Diseases for Gout

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Diseases in the Gout family:

Gout, Hprt1-Related

Diseases related to Gout via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 132)
idRelated DiseaseScoreTop Affiliating Genes
1phosphoribosylpyrophosphate synthetase superactivity31.0PRPS1
2hprt-related gout30.9APRT, HPRT1
3nephrolithiasis30.3XDH, APRT, UMOD
4hyperuricemic nephropathy, familial juvenile 130.2HPRT1, HNF1B, UMOD
5hyperuricemia30.2HPRT1, SLC17A3, XDH, APRT, PRPS1, UMOD
6lesch-nyhan syndrome30.0HPRT1, PRPS1, ADSL, APRT, XDH
7cystic kidney30.0UMOD, HNF1B
8arthritis10.7
9kidney disease10.5
10arthropathy10.3
11familial juvenile hyperuricaemic nephropathy10.3
12rheumatoid arthritis10.3
13blindness10.3
14hypouricemia, renal10.3HPRT1, SLC22A12
15synovitis10.3
16acute urate nephropathy10.3XDH, HPRT1
17immunodeficiency due to purine nucleoside phosphorylase deficiency10.2HPRT1, APRT
18gout susceptibility 410.2
19atherosclerosis10.2
20osteoarthritis10.2
21cardiovascular disease risk factor10.2
22xanthinuria10.2APRT, XDH
23myocardial infarction10.2
24obesity10.2
25chondrocalcinosis10.2
26septic arthritis10.2
27bursitis10.2
28interstitial nephritis10.2UMOD, APRT
29reflex sympathetic dystrophy10.1
30gastric ulcer10.1
31mixed connective tissue disease10.1
32cerebrovascular disease10.1
33connective tissue disease10.1
34xanthomatosis10.1
35adenine phosphoribosyltransferase deficiency10.1
36glycogen storage disease10.1
37kearns-sayre syndrome10.1
38epidural abscess10.1
39nephronophthisis10.1
40gout, hprt1-related10.1
41developmental disabilities10.1HPRT1, HNF1B
42systemic lupus erythematosus10.0
43medullary cystic kidney disease 110.0
44prostate cancer10.0
45chondrocalcinosis 210.0
46factor xii deficiency10.0
47medullary cystic kidney disease 210.0
48coronary artery disease10.0
49polymyalgia rheumatica10.0
50hypercalcemia10.0

Graphical network of the top 20 diseases related to Gout:



Diseases related to gout

Symptoms for Gout

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Drugs & Therapeutics for Gout

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Genetic Tests for Gout

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Anatomical Context for Gout

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MalaCards organs/tissues related to Gout:

31
Kidney, Liver, Skin, Heart, Neutrophil, Bone, Testes, Lung, Prostate, Monocytes, Colon, Thyroid

FMA organs/tissues related to Gout:

14
Joint

Animal Models for Gout or affiliated genes

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MGI Mouse Phenotypes related to Gout:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.1SLC22A12, ALDH2, UMOD, HPRT1, APRT
2MP:00053678.1SLC22A12, HNF1B, UMOD, HPRT1, APRT, XDH
3MP:00107687.3XDH, APRT, HPRT1, HNF1B, ALDH2, SLC22A12
4MP:00053877.3XDH, APRT, HPRT1, UMOD, HNF1B, ALDH2
5MP:00053787.2XDH, APRT, HPRT1, UMOD, HNF1B, ALDH2
6MP:00053767.1XDH, APRT, HPRT1, UMOD, HNF1B, ALDH2

Publications for Gout

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Articles related to Gout:

(show top 50)    (show all 821)
idTitleAuthorsYear
1
Response to: 'Risk of vascular disease with gout: overadjustment of the statistical analyses?' by van Durme et al. (25351520)
2014
2
Prevalence and correlates of gout in a large cohort of patients with chronic kidney disease: the German Chronic Kidney Disease (GCKD) study. (25395390)
2014
3
Frequency of CYP2C9 polymorphisms in polynesian people and potential relevance to management of gout with benzbromarone. (23932726)
2013
4
A qualitative and quantitative analysis of the characteristics of gout patient education resources. (23322247)
2013
5
Obstructive sleep apnoea, gout and cardiovascular risk: a worth studying association. (23937998)
2013
6
Rilonacept for gout flare prevention during initiation of uric acid-lowering therapy: results from the PRESURGE-2 international, phase 3, randomized, placebo-controlled trial. (23485476)
2013
7
The distribution of urate deposition within the extremities in gout: a review of 148 dual-energy CT cases. (24337414)
2013
8
Polyarticular sonographic assessment of gout: a hospital-based cross-sectional study. (23142256)
2013
9
Common variants of a urate-associated gene LRP2 are not associated with gout susceptibility. (24366390)
2013
10
Uric acid as a danger signal in gout and its comorbidities. (22945591)
2013
11
Increased prevalence of simple renal cysts in patients with gout. (22453524)
2013
12
Intra-articular glucocorticoids for acute gout. (23633379)
2013
13
Sugar-sweetened beverage consumption: a risk factor for prevalent gout with SLC2A9 genotype-specific effects on serum urate and risk of gout. (24026676)
2013
14
Tophus burden reduction with pegloticase: results from phase 3 randomized trials and open-label extension in patients with chronic gout refractory to conventional therapy. (24286509)
2013
15
Monosodium urate (gout) crystals, an uncommon finding in ThinPrep synovial fluid cytology. (21964923)
2013
16
Metabolic Interactions of Purine Derivatives with Human ABC Transporter ABCG2: Genetic Testing to Assess Gout Risk. (24287461)
2013
17
A small disturbance, but a serious disease: the possible mechanism of D52H-mutant of human PRS1 that causes gout. (23509005)
2013
18
Benefit restrictions and gout treatment. (24156646)
2013
19
OMERACT Endorsement of Measures of Outcome for Studies of Acute Gout. (24334651)
2013
20
Women with gout: efficacy and safety of urate-lowering with febuxostat and allopurinol. (22052584)
2012
21
Spinal gout: a great mimicker. A case report and literature review. (24029100)
2012
22
Silent gout: an unusual presentation in diabetic neuropathy. (22854386)
2012
23
Gout and osteoarthritis: a pathogenetic link? (22867976)
2012
24
Tophaceous pustule-like rash in a patient with gout. (22210683)
2012
25
Prescription and dosing of urate-lowering therapy, rather than patient behaviours, are the key modifiable factors associated with targeting serum urate in gout. (22978848)
2012
26
Improved health-related quality of life and physical function in patients with refractory chronic gout following treatment with pegloticase: evidence from phase III randomized controlled trials. (22660805)
2012
27
Crystal arthritis: Canakinumab relieves gout flares when treatment options are limited. (22641137)
2012
28
Juvenile gout: rare and aggressive. (22602839)
2012
29
Febuxostat: a novel agent for management of hyperuricemia in gout. (23112391)
2011
30
Gout measures: Gout Assessment Questionnaire (GAQ, GAQ2.0), and physical measurement of tophi. (22588771)
2011
31
How clinical and research failures lead to suboptimal prescribing: the example of chronic gout. (22134968)
2011
32
The mechanisms of inflammation in gout and pseudogout (CPP-induced arthritis). (22303529)
2011
33
Genetic analysis of ABCG2 gene C421A polymorphism with gout disease in Chinese Han male population. (19921266)
2010
34
The cyclic GMP-dependent protein kinase II gene associates with gout disease: identified by genome-wide analysis and case-control study. (18678579)
2009
35
Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout. (19506252)
2009
36
A critical reappraisal of allopurinol dosing, safety, and efficacy for hyperuricemia in gout. (19296886)
2009
37
Benjamin Franklin's risk factors for gout and stones: from genes and diet to possible lead poisoning. (19244863)
2008
38
A case of verrucous carcinoma (epithelioma cuniculatum) of the heel mimicking infected epidermal cyst and gout. (19825731)
2008
39
SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. (18327257)
2008
40
Tophaceous gout of the lumbar spine mimicking pyogenic discitis. (17197341)
2007
41
Markers of vascular endothelium activation in gout]. (15989007)
2005
42
Purine metabolites in gout and asymptomatic hyperuricemia: analysis by HPLC-electrospray tandem mass spectrometry. (16120958)
2005
43
Interleukin-1 receptor antagonist gene polymorphism in Taiwanese patients with gout. (15789892)
2005
44
Reduced incidence of hyperuricemia, gout, and renal failure following liver transplantation in comparison to heart transplantation: a long-term follow-up study. (15239625)
2004
45
Evaluation of crystals in formalin-fixed, paraffin-embedded tissue sections for the differential diagnosis of pseudogout, gout, and tumoral calcinosis. (11504841)
2001
46
Gout, uric acid and purine metabolism in paediatric nephrology. (8439471)
1993
47
Gout and pseudogout in hospitalized patients. (8257255)
1993
48
Recurrent hemarthrosis associated with gout. (1555350)
1992
49
Coexistence of rheumatoid nodulosis and gout. (3772930)
1986
50
Gout and pseudogout precipitated by parathyroidectomy. (7112087)
1982

Variations for Gout

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Expression for genes affiliated with Gout

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Search GEO for disease gene expression data for Gout.

Pathways for genes affiliated with Gout

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Pathways related to Gout according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
One Carbon Metabolism36
dTMP de novo biosynthesis (mitochondrial)36
tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate36
Trans-sulfuration and one carbon metabolism36
methionine salvage36
Methionine metabolism58
9.8PRPS1, HPRT1
2
Show member pathways
guanosine nucleotides de novo biosynthesis36
guanosine ribonucleotides de novo biosynthesis36
adenosine ribonucleotides de novo biosynthesis36
purine nucleotides de novo biosynthesis36
9.8APRT, HPRT1
39.7XDH, SLC22A12
49.2HPRT1, ADSL, PRPS1
5
Show member pathways
Retinol metabolism58
9.2XDH, ALDH2
6
Show member pathways
8.9XDH, HPRT1, ALDH2
7
Show member pathways
purine deoxyribonucleosides degradation36
purine nucleotides degradation36
adenine and adenosine salvage II36
adenine and adenosine salvage III36
oxidized GTP and dGTP detoxification36
urate biosynthesis/inosine 5-phosphate degradation36
adenine and adenosine salvage I36
purine ribonucleosides degradation to ribose-1-phosphate36
inosine-5-phosphate biosynthesis36
guanosine nucleotides degradation36
guanine and guanosine salvage36
adenosine nucleotides degradation36
5-aminoimidazole ribonucleotide biosynthesis36
8.7HPRT1, ADSL, APRT, XDH
8
Show member pathways
UTP and CTP dephosphorylation II36
ATP ITP metabolism58
purine deoxyribonucleosides salvage36
8.3ADSL, PRPS1, APRT, XDH, HPRT1
9
Show member pathways
7.5HPRT1, ALDH2, ADSL, APRT, PRPS1, XDH

Compounds for genes affiliated with Gout

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Compounds related to Gout according to GeneCards Suite gene sharing:

(show all 46)
idCompoundScoreTop Affiliating Genes
1ethyl methanesulfonate4310.1HPRT1, APRT
22-amino-3-methylimidazo(4,5-f)quinoline4310.1HPRT1, APRT
36-thiouric acid4310.1XDH, HPRT1
4tiazofurin4310.1XDH, HPRT1
5bpde4310.1HPRT1, APRT
6benzbromarone4310.1XDH, SLC22A12
7mercaptopurine49 1211.1HPRT1, XDH
8pyrazinamide43 49 1212.1XDH, SLC22A12
9didanosine43 49 1212.0HPRT1, XDH
10phip4310.0APRT, HPRT1
11thiopurine4310.0XDH, HPRT1
126 mercaptopurine4310.0HPRT1, XDH
13calcium oxalate439.9UMOD, APRT
14probenecid28 43 59 49 1213.8SLC22A12, XDH
155-Aminoimidazole-4-carboxamide249.8APRT, ADSL
16Phosphoribosyl pyrophosphate249.8HPRT1, PRPS1, APRT
17benzo(a)pyrene439.8HPRT1, APRT
18adenylosuccinate439.8APRT, ADSL
19nicotinamide43 1210.8HNF1B, HPRT1
202,8-dihydroxyadenine439.7HPRT1, APRT, XDH
21molybdenum43 2410.7ADSL, XDH
22inosine43 2410.7XDH, APRT, HPRT1
235-methylthioadenosine439.7APRT, ADSL
24losartan43 49 28 1212.7SLC22A12, XDH
25phosphoric acid43 2410.7APRT, PRPS1, HPRT1
26aicar43 24 1211.6ADSL, APRT
27pyrophosphate43 2410.6HPRT1, PRPS1, APRT
28guanine43 24 1211.6HPRT1, APRT, XDH
29inosine monophosphate439.6HPRT1, ADSL, APRT
30nucleoside439.5HPRT1, ADSL, APRT
31peroxynitrite439.4UMOD, XDH
32betacarotene439.4HPRT1, ALDH2
33acetaldehyde28 43 2411.3ALDH2, HPRT1, XDH
34prpp439.2APRT, ADSL, PRPS1, HPRT1
35allopurinol43 49 1211.2UMOD, HPRT1, APRT, XDH
36Adenosine monophosphate24 1210.2APRT, ADSL, PRPS1, HPRT1
37purine nucleoside439.1XDH, APRT, ADSL, HPRT1
38hypoxanthine43 24 1211.1HPRT1, ADSL, APRT, XDH
39xanthine43 2410.1XDH, APRT, ADSL, HPRT1
40adenine43 24 1211.1XDH, APRT, ADSL, HPRT1
41thymidine43 249.8HPRT1, ADSL, APRT
42purine43 249.8XDH, APRT, ADSL, PRPS1, HPRT1
43arginine438.6ALDH2, HNF1B, HPRT1, XDH
44cysteine438.6XDH, HPRT1, UMOD, ALDH2
45creatinine437.9APRT, ADSL, HPRT1, UMOD, ALDH2, SLC22A12
46uric acid43 248.4SLC22A12, XDH, APRT, ADSL, PRPS1, HPRT1

GO Terms for genes affiliated with Gout

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Cellular components related to Gout according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1brush border membraneGO:00315269.5SLC22A12, SLC17A3
2apical plasma membraneGO:00163249.2UMOD, SLC17A3, SLC22A12
3cytosolGO:00058298.3HPRT1, PRPS1, ADSL, APRT, XDH
4extracellular vesicular exosomeGO:00700628.1SLC22A12, ALDH2, UMOD, HPRT1, APRT

Biological processes related to Gout according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1organic acid transportGO:001584910.0SLC22A12, SLC17A3
2adenine salvageGO:00061689.9HPRT1, APRT
3urate transportGO:00157479.9SLC22A12, SLC17A3
4purine ribonucleoside salvageGO:00061669.8APRT, HPRT1
5urate metabolic processGO:00464159.8SLC22A12, SLC17A3
6purine-containing compound salvageGO:00431019.7APRT, HPRT1
7AMP biosynthetic processGO:00061679.6ADSL, PRPS1
8lactationGO:00075959.6APRT, XDH
9grooming behaviorGO:00076259.5HPRT1, APRT
10purine nucleotide biosynthetic processGO:00061649.5ADSL, PRPS1, HPRT1
11nucleobase-containing small molecule metabolic processGO:00550868.9XDH, APRT, ADSL, HPRT1
12purine nucleobase metabolic processGO:00061448.6HPRT1, PRPS1, ADSL, APRT, XDH
13small molecule metabolic processGO:00442817.7XDH, APRT, ADSL, PRPS1, HPRT1, ALDH2

Molecular functions related to Gout according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1urate transmembrane transporter activityGO:00151439.8SLC22A12, SLC17A3
2AMP bindingGO:00162089.6PRPS1, APRT
3electron carrier activityGO:00090559.2ALDH2, XDH
4protein homodimerization activityGO:00428038.6XDH, PRPS1, HPRT1, HNF1B

Products for genes affiliated with Gout

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Sources for Gout

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