GOUT
MCID: GT001
MIFTS: 66

Gout (GOUT) malady

Summaries for Gout

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8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Gout is a common, painful form of arthritis. it causes swollen, red, hot and stiff joints. gout happens when uric acid builds up in your body. uric acid comes from the breakdown of substances called purines. purines are in your body's tissues and in foods, such as liver, dried beans and peas, and anchovies. normally, uric acid dissolves in the blood. it passes through the kidneys and out of the body in urine. but sometimes uric acid can build up and form needle-like crystals. when they form in your joints, it is very painful. the crystals can also cause kidney stones. often, gout first attacks your big toe. it can also attack ankles, heels, knees, wrists, fingers, and elbows. at first, gout attacks usually get better in days. eventually, attacks last longer and happen more often. you are more likely to get gout if you are a man have family member with gout are overweight drink alcohol eat too many foods rich in purines gout can be hard to diagnose. your doctor may take a sample of fluid from an inflamed joint to look for crystals. you can treat gout with medicines. pseudogout has similar symptoms and is sometimes confused with gout. however, it is caused by calcium phosphate, not uric acid. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Gout, also known as gouty arthropathy, is related to hyperuricemia and arthritis. An important gene associated with Gout is HPRT1 (hypoxanthine phosphoribosyltransferase 1), and among its related pathways are Purine metabolism and Purine metabolism. The drugs indomethacin and sulindac and the compounds uric acid and creatinine have been mentioned in the context of this disorder. Affiliated tissues include joint, kidney and liver, and related mouse phenotypes are homeostasis/metabolism and renal/urinary system.

Disease Ontology:8 An arthritis that has material basis in uric acid crystal deposits located in joint.

CDC:3 Gout is a rheumatic disease resulting from deposition of uric acid crystals (monosodium urate) in tissues and fluids within the body. This process is caused by an overproduction or under excretion of uric acid. Certain common medications, alcohol, and dietary foods are known to be contributory factors. Acute gout will typically manifest itself as an acutely red, hot, and swollen joint with excruciating pain. These acute gouty flare-ups respond well to treatment with oral anti-inflammatory medicines and may be prevented with medication and diet changes. Recurrent bouts of acute gout can lead to a degenerative form of chronic arthritis called gouty arthritis.

Wikipedia:63 Gout (also known as podagra when it involves the big toe) is a medical condition usually characterized... more...

Aliases & Classifications for Gout

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Related Diseases for Gout

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17GeneCards, 18GeneDecks
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Diseases in the Gout family:

Gout, Hprt1-Related

Diseases related to Gout via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 130)
idRelated DiseaseScoreTop Affiliating Genes
1hyperuricemia31.3SLC17A3, SLC22A12, HPRT1, XDH, PRPS1, UMOD
2arthritis30.9S100A9, HPRT1, IL1B
3synovitis30.3IL1B
4arthropathy30.3IL1B, S100A9
5lesch-nyhan syndrome30.3APRT, PRPS1, XDH, HPRT1, PNP, ADSL
6atherosclerosis30.2LCAT, S100A9, XDH, IL1B
7hprt-related gout30.2APRT, HPRT1
8phosphoribosylpyrophosphate synthetase superactivity30.2PRPS1
9nephrolithiasis30.1APRT, UMOD, XDH, HPRT1, SLC22A12
10familial juvenile hyperuricemic nephropathy30.1HNF1B, UMOD, HPRT1
11obesity30.1ALDH2, LCAT
12tuberculosis30.0PNP, IL1B
13diabetes mellitus29.7HNF1B, LCAT, UMOD, IL1B, ALDH2
14alzheimer's disease29.7S100A9, HPRT1, IL1B, ALDH2
15cystic kidney29.7UMOD, HNF1B
16liver cirrhosis29.7ALDH2, LCAT
17pseudogout10.6
18kidney disease10.4
19hypertension10.3
20rheumatoid arthritis10.2
21osteoarthritis10.2
22septic arthritis10.1
23bursitis10.1
24myocardial infarction10.1
25familial juvenile hyperuricaemic nephropathy10.1
26reflex sympathetic dystrophy10.1
27mixed connective tissue disease10.1
28gastric ulcer10.1
29autosomal dominant disease10.1
30cerebrovascular disease10.1
31connective tissue disease10.1
32xanthomatosis10.1
33parkinson's disease10.1
34epidural abscess10.1
35nephronophthisis10.1
36glycogen storage disease10.1
37adenine phosphoribosyltransferase deficiency10.1
38umod-associated kidney disease10.1
39gout susceptibility 410.1
40metabolic syndrome x10.0LCAT, APRT, XDH, PNP, ALDH2, ADSL
41leukemia10.0S100A9, APRT, HPRT1, IL1B, PNP, ALDH2
42acute kidney failure10.0SLC22A12, HPRT1, XDH, UMOD
43cork-handlers' disease10.0ALDH2, PNP, IL1B, S100A9
44chronic kidney failure10.0HNF1B, LCAT, APRT, UMOD
45glomerulonephritis10.0IL1B, XDH, UMOD
46purine nucleoside phosphorylase deficiency10.0HPRT1, APRT
47pneumonia10.0XDH, IL1B
48interstitial nephritis10.0APRT, UMOD
49acute urate nephropathy10.0XDH, HPRT1
50renal hypouricemia10.0HPRT1, SLC22A12

Graphical network of the top 20 diseases related to Gout:



Diseases related to gout

Clinical Features for Gout

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Drugs & Therapeutics for Gout

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Gout

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Anatomical Context for Gout

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Gout:

32
Kidney, Liver, Skin, Heart, Bone, Monocytes, Testes, Prostate, Lung, Thyroid, Colon

FMA organs/tissues related to Gout:

14
Joint

Animal Models for Gout or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gout:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537611.3HNF1B, LCAT, S100A9, APRT, UMOD, XDH
2MP:000536711.2SLC22A12, HNF1B, LCAT, APRT, UMOD, XDH
3MP:000539711.2S100A9, APRT, UMOD, HPRT1, PNP, SLC22A12
4MP:000538710.9HNF1B, S100A9, APRT, UMOD, XDH, HPRT1

Publications for Gout

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50PubMed
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Articles related to Gout:

(show top 50)    (show all 780)
idTitleAuthorsYear
1
The effect of febuxostat to prevent a further reduction in renal function of patients with hyperuricemia who have never had gout and are complicated by chronic kidney disease stage 3: study protocol for a multicenter randomized controlled study. (24433285)
2014
2
Re: Hasegawa EM, Fuller R, Chammas MC, de Mello FM, Goldenstein-Schainberg C: Increased prevalence of simple renal cysts in patients with gout. Rheumatol Int, DOI 10.1007/s00296-012-2380-x. (23377532)
2014
3
Gout in a 15-year-old boy with juvenile idiopathic arthritis: a case study. (24393408)
2014
4
New ACR guidelines for gout management hold some surprises. (23229452)
2013
5
ALPK1 genetic regulation and risk in relation to gout. (23569188)
2013
6
The association of gout with sleep disorders: a cross-sectional study in primary care. (23557073)
2013
7
Masses in the extensor mechanism of the knee: an unusual presentation of gout. (24422370)
2013
8
Effect of commonly prescribed drugs on incidence of gout. (24150676)
2013
9
Sack and sugar, and the aetiology of gout in England between 1650 and 1900. (23175570)
2013
10
Relative and attributable diabetes risk associated with hyperuricemia in US veterans with gout. (23620537)
2013
11
Gout, hyperuricaemia, sleep apnoea-hypopnoea syndrome and vascular risk. (23418048)
2013
12
Racial Differences in Gout Incidence in a Population-Based Cohort: Atherosclerosis Risk in Communities Study. (24335384)
2013
13
Virtual and in vitro bioassay screening of phytochemical inhibitors from flavonoids and isoflavones against xanthine oxidase and cyclooxygenase-2 for gout treatment. (23534413)
2013
14
ACTH as first line treatment for acute gout in 181A hospitalized patients. (23195793)
2013
15
Association of Functional Polymorphism rs2231142 (Q141K) in the ABCG2 Gene With Serum Uric Acid and Gout in 4 US Populations: The PAGE Study. (23552988)
2013
16
Innate immunity functional gene polymorphisms and gout susceptibility. (23639963)
2013
17
Silent gout: an unusual presentation in diabetic neuropathy. (22854386)
2012
18
Latest evidence on gout management: what the clinician needs to know. (23342241)
2012
19
Imaging: Dual-energy CT useful when assessing tophaceous gout. (22249161)
2012
20
Gout: thoughts about a treat-to-target programme. (23079069)
2012
21
Clarification of the modified radiographic damage scoring method for gout. (22467953)
2012
22
Enhanced interleukin-1I^ production of PBMCs from patients with gout after stimulation with Toll-like receptor-2 ligands and urate crystals. (22762240)
2012
23
The diagnostic value of the proposal for clinical gout diagnosis (CGD). (21979446)
2012
24
Physical signs for the general dental practitioner. Case 91. Gout. (22720386)
2012
25
Images in clinical medicine. Tophaceous gout. (22256825)
2012
26
Association between gout and polymorphisms in GCKR in male Han Chinese. (22395765)
2012
27
The patient's experience of gout: new insights to optimize management. (22198831)
2012
28
False-negative dual-energy computed tomography in a patient with acute gout. (22426590)
2012
29
Pegloticase for treating refractory chronic gout. (22844655)
2012
30
Comparison of patient characteristics and gout-related health-care resource utilization and costs in patients with frequent versus infrequent gouty arthritis attacks. (22829689)
2012
31
A perspective on diet and gout. (23089274)
2012
32
Spinal gout tophus: a very rare cause of radiculopathy. (21594750)
2012
33
Cervical arthropathy caused by gout: stabilisation without decompression. (20938786)
2011
34
A challenging case of gout and failure of anti-TNF therapy- are current treatments adequate? (21816013)
2011
35
A metabolic profiling analysis of symptomatic gout in human serum and urine using high performance liquid chromatography-diode array detector technique. (21867696)
2011
36
The genetic basis of hyperuricaemia and gout. (20472486)
2011
37
Gout in the writings of eminent ancient Greek and Byzantine physicians. (22047483)
2011
38
Genetic analysis of ABCG2 gene C421A polymorphism with gout disease in Chinese Han male population. (19921266)
2010
39
A strong role for the ABCG2 gene in susceptibility to gout in New Zealand Pacific Island and Caucasian, but not MA8ori, case and control sample sets. (20858603)
2010
40
A prescription for lifestyle change in patients with hyperuricemia and gout. (20035225)
2010
41
Effect of metformin on the clinical course of gout and insulin resistance]. (19705791)
2009
42
New knowledge on the pathophysiology and therapy of gout]. (17924125)
2007
43
Gout. (15103259)
2004
44
A literature review of the epidemiology and treatment of acute gout. (12860487)
2003
45
Tophaceous gout and pseudogout of the middle ear and the infratemporal fossa: case report and review of the literature. (14587571)
2003
46
Enthesopathy and tendinopathy in gout: computed tomographic assessment. (9014587)
1996
47
Recurrent hemarthrosis associated with gout. (1555350)
1992
48
Coexistence of rheumatoid nodulosis and gout. (3772930)
1986
49
Simultaneous gout, pseudogout, and septic arthritis. (7352936)
1980
50
Crystal-induced inflammation; syndromes of gout and pseudogout. (13932059)
1963

Genetic Variations for Gout

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Expression for genes affiliated with Gout

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gout

Search GEO for disease gene expression data for Gout.

Pathways for genes affiliated with Gout

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29KEGG, 12EMD Millipore, 53Reactome, 37NCBI BioSystems Database, 49PharmGKB
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Compounds for genes affiliated with Gout

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44Novoseek, 24HMDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Gout according to GeneCards/GeneDecks:

(show all 50)
idCompoundScoreTop Affiliating Genes
1uric acid44 2412.7ADSL, HNF1B, APRT, UMOD, PRPS1, XDH
2creatinine4411.5APRT, UMOD, HPRT1, PNP, SLC22A12, ALDH2
3purine44 2412.4APRT, PRPS1, XDH, HPRT1, PNP, ADSL
4prpp4411.4APRT, PRPS1, HPRT1, PNP, ADSL
5purine nucleoside4411.3APRT, XDH, HPRT1, PNP, ADSL
6hypoxanthine44 11 2413.3APRT, XDH, HPRT1, PNP, ADSL
7xanthine44 2412.3APRT, XDH, HPRT1, PNP, ADSL
8adenine44 11 2413.3APRT, XDH, HPRT1, PNP, ADSL
9glutamate4411.3LCAT, GLUD2, HPRT1, PNP, ALDH2, ADSL
10allopurinol44 49 1113.3APRT, UMOD, XDH, HPRT1
11inosine44 2412.2APRT, XDH, HPRT1, PNP
12thymidine44 2412.2APRT, HPRT1, IL1B, PNP, ADSL
13inosine monophosphate4411.2ADSL, PNP, HPRT1, APRT
14acetaldehyde44 28 2413.2LCAT, XDH, HPRT1, ALDH2
15nucleoside4411.2APRT, HPRT1, PNP, ADSL
16cysteine4411.2LCAT, UMOD, XDH, HPRT1, PNP, ALDH2
17guanine44 11 2413.2PNP, HPRT1, XDH, APRT
182,8-dihydroxyadenine4411.2HPRT1, XDH, APRT
19methotrexate44 49 1113.2S100A9, HPRT1, IL1B, SLC22A11
20adenylosuccinate4411.1ADSL, PNP, APRT
21molybdenum44 2412.1XDH, PNP, ADSL
22thiopurine4411.1PNP, HPRT1, XDH
23Adenosine monophosphate11 2412.1ADSL, HPRT1, PRPS1, APRT
245-methylthioadenosine4411.1APRT, PNP, ADSL
25probenecid44 28 59 49 1115.1XDH, SLC22A11, SLC22A12
26h2o24411.1S100A9, APRT, XDH, HPRT1, PNP
279-deazaguanine44 1112.1PNP, HPRT1
28Alpha-Phosphoribosylpyrophosphoric Acid1111.0APRT, HPRT1
298-azaguanine44 1112.0HPRT1, PNP
306-thiouric acid4411.0XDH, HPRT1
31febuxostat59 4412.0PNP, XDH
32benzbromarone4411.0SLC22A12, XDH
33aaph4411.0LCAT, XDH
344-hydroxynonenal44 2412.0ALDH2, XDH, LCAT
35pyrophosphate44 2412.0APRT, PRPS1, HPRT1, PNP
36ethyl methanesulfonate4411.0HPRT1, APRT
372,3-dideoxyadenosine4411.0IL1B, PNP
38pyrazinamide44 49 1113.0XDH, SLC22A12
39mercaptopurine49 1111.9XDH, HPRT1
40monosodium urate4410.9S100A9, IL1B
412-amino-3-methylimidazo(4,5-f)quinoline4410.9APRT, HPRT1
42calcium oxalate4410.9APRT, UMOD
43azathioprine44 49 2 1113.9PNP, HPRT1, XDH
44tiazofurin4410.9HPRT1
454-ipp5910.8S100A9, IL1B
46alpha tocopherol4410.7LCAT, XDH, ALDH2
47git 275910.7S100A9, IL1B
48deoxyadenosine44 2411.6PNP, APRT
49guanylate4410.6ALDH2, PNP, HPRT1
50didanosine44 1111.3PNP, HPRT1

GO Terms for genes affiliated with Gout

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16Gene Ontology
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Cellular components related to Gout according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1apical plasma membraneGO:01632410.8SLC17A3, SLC22A12, SLC22A11, UMOD

Biological processes related to Gout according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:04428111.3LCAT, APRT, PRPS1, XDH, HPRT1, PNP
2purine nucleobase metabolic processGO:00614411.3ADSL, PNP, HPRT1, XDH, PRPS1, APRT
3nucleobase-containing small molecule metabolic processGO:05508611.2APRT, XDH, HPRT1, PNP, ADSL
4purine nucleotide biosynthetic processGO:00616411.0PRPS1, HPRT1, ADSL
5urate metabolic processGO:04641510.9SLC17A3, SLC22A12, SLC22A11
6purine-containing compound salvageGO:04310110.9PNP, HPRT1, APRT
7urate biosynthetic processGO:03441810.8PRPS1, PNP
8urate transportGO:01574710.8SLC22A12, SLC17A3
9adenine salvageGO:00616810.7APRT, HPRT1
10purine ribonucleoside salvageGO:00616610.6HPRT1, APRT
11grooming behaviorGO:00762510.6HPRT1, APRT
12organic anion transportGO:01571110.5SLC17A3, SLC22A11
13purine nucleotide catabolic processGO:00619510.3PNP, XDH

Molecular functions related to Gout according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1organic anion transmembrane transporter activityGO:00851410.6SLC17A3, SLC22A11
2urate transmembrane transporter activityGO:01514310.3SLC17A3, SLC22A12

Products for genes affiliated with Gout

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Sources for Gout

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet