MCID: GRD007
MIFTS: 39

Grade Iii Astrocytoma malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Summaries for Grade Iii Astrocytoma

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NIH Rare Diseases:41 Anaplastic astrocytoma is a rare, cancerous (malignant) type of brain tumor that arises from star-shaped brain cells called astrocytes. these cells surround and protect nerve cells in the brain and spinal cord. an anaplastic astrocytoma usually develops slowly over time, but may develop rapidly. signs and symptoms vary depending on the location and size of the tumor and may include headaches, drowsiness, vomiting, and changes in personality or mental status. some affected people have seizures, vision problems, weakness of the limbs, and/or coordination problems. anaplastic astroctyomas usually occur sporadically but can be associated with a few rare, genetic disorders. treatment may include surgery, radiation, and/or chemotherapy. last updated: 11/3/2014

MalaCards based summary: Grade Iii Astrocytoma, also known as anaplastic astrocytoma, is related to renal cell carcinoma and astrocytoma. An important gene associated with Grade Iii Astrocytoma is IDH2 (isocitrate dehydrogenase 2 (NADP+), mitochondrial), and among its related pathways are Integrated Pancreatic Cancer Pathway and Chks in Checkpoint Regulation. The drugs cisplatin and temozolomide and the compounds olomoucine and 8-oxo-dg have been mentioned in the context of this disorder. Affiliated tissues include brain and spinal cord.

Disease Ontology:9 An astrocytoma that is characterized by cells with regular, round to oval nuclei.

Aliases & Classifications for Grade Iii Astrocytoma

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Sources:
41NIH Rare Diseases, 60UMLS, 9Disease Ontology, 43Novoseek, 47Orphanet, 38NCIt, 33MeSH, 55SNOMED-CT, 61UMLS via Orphanet
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Grade Iii Astrocytoma, Aliases & Descriptions:

Name: Grade Iii Astrocytoma 9 41
Anaplastic Astrocytoma 9 41 43 47 60
Astrocytoma 41 60
Gliosarcoma 41 60
High Grade Astrocytic Tumor 60
 
Grade Iii Astrocytic Tumor 9
High-Grade Astrocytoma 41
Malignant Astrocytoma 41
Astrocytic Tumor 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

47
anaplastic astrocytoma:
Inheritance: Not applicable; Age of onset: Adult


External Ids:

Disease Ontology9 DOID:3078
NCIt38 C9477
MeSH33 D001254
SNOMED-CT55 55353007
Orphanet47 251589
UMLS via Orphanet61 C0334579

Related Diseases for Grade Iii Astrocytoma

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Diseases related to Grade Iii Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 263)
idRelated DiseaseScoreTop Affiliating Genes
1renal cell carcinoma30.8TP53
2astrocytoma30.7TP53, PCNA
3malignant glioma30.2IDH2, TP53, PCNA
4colorectal cancer30.0PCNA, TP53
5glioblastoma30.0PCNA, TP53, IDH2
6oligodendroglioma30.0TP53, PCNA
7retinoblastoma29.9PCNA, TP53
8breast cancer29.8TP53, PCNA
9papilloma29.8PCNA, TP53
10gliosarcoma11.2
11subependymal giant cell astrocytoma10.9
12cerebellar astrocytoma10.8
13tuberous sclerosis10.8
14pilomyxoid astrocytoma10.7
15juvenile pilocytic astrocytoma10.7
16spinal cord astrocytoma10.7
17cerebritis10.5
18gemistocytic astrocytoma10.5
19desmoplastic infantile astrocytoma10.4
20neuroblastoma10.4
21melanoma and neural system tumor syndrome10.4
22glioblastoma multiforme10.4
23protoplasmic astrocytoma10.4
24childhood cerebral astrocytoma10.3
25adult brainstem gliosarcoma10.3
26myelodysplastic syndrome10.3
27oligoastrocytoma10.3
28meningitis10.3
29sarcoma10.3
30hypoxia10.3
31diencephalic syndrome10.3
32juvenile astrocytoma10.2
33diencephalic astrocytomas10.2
34pilocytic astrocytoma of cerebellum10.2
35childhood pilocytic astrocytoma10.2
36optic nerve astrocytoma10.2
37retinitis10.2
38subependymoma10.2
39pituicytoma10.2
40meningioma, familial10.2PCNA
41neurofibromatosis10.2
42herpes simplex10.2
43dysembryoplastic neuroepithelial tumor10.2
44childhood optic tract astrocytoma10.2
45mixed oligodendroglioma-astrocytoma10.2
46hiv-110.1
47hydrocephalus10.1
48mixed astrocytoma-ependymoma10.1
49mixed astrocytoma-ependymoma-oligodendroglioma10.1
50childhood brainstem astrocytoma10.1

Graphical network of the top 20 diseases related to Grade Iii Astrocytoma:



Diseases related to grade iii astrocytoma

Symptoms for Grade Iii Astrocytoma

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Drugs & Therapeutics for Grade Iii Astrocytoma

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Drug clinical trials:

Search ClinicalTrials for Grade Iii Astrocytoma

Search NIH Clinical Center for Grade Iii Astrocytoma

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Grade Iii Astrocytoma

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Anatomical Context for Grade Iii Astrocytoma

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MalaCards organs/tissues related to Grade Iii Astrocytoma:

31
Brain, Spinal cord

Animal Models for Grade Iii Astrocytoma or affiliated genes

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Publications for Grade Iii Astrocytoma

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Articles related to Grade Iii Astrocytoma:

idTitleAuthorsYear
1
Prolonged survival associated with the use of intraoperative carmustine (Gliadel) in a paediatric patient with recurrent Grade III astrocytoma. (23391098)
2013
2
Proliferating cell nuclear antigen, p53 and micro vessel density: Grade II vs. Grade III astrocytoma. (20090216)
2010
3
Regression of grade III astrocytoma during the treatment of CML with imatinib mesylate. (16988542)
2006
4
Mdr1 mRNA expression differs between grade III astrocytomas and glioblastomas. (9020393)
1997
5
Ukrain therapy in a frontal anaplastic grade III astrocytoma (case report). (8899347)
1996
6
p53 mutations are associated with 17p allelic loss in grade II and grade III astrocytoma. (1349850)
1992

Variations for Grade Iii Astrocytoma

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Expression for genes affiliated with Grade Iii Astrocytoma

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Search GEO for disease gene expression data for Grade Iii Astrocytoma.

Pathways for genes affiliated with Grade Iii Astrocytoma

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Pathways related to Grade Iii Astrocytoma according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1TP53, PCNA
2
Show member pathways
9.1PCNA, TP53
3
Show member pathways
9.1PCNA, TP53
4
Show member pathways
9.1PCNA, TP53
5
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.1PCNA, TP53
69.1PCNA, TP53
7
Show member pathways
9.1PCNA, TP53
8
Show member pathways
Cell cycle36
9.1PCNA, TP53
99.1TP53, PCNA
109.1PCNA, TP53
119.1PCNA, TP53
129.1PCNA, TP53
139.1TP53, PCNA
149.1PCNA, TP53
15
Show member pathways
Signal transduction PTEN pathway58
9.1PCNA, TP53
16
Show member pathways
Development IGF RI signaling
Immune response IL 4 signaling pathway58
Signal transduction AKT signaling58
9.1PCNA, TP53
179.1PCNA, TP53

Compounds for genes affiliated with Grade Iii Astrocytoma

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Compounds related to Grade Iii Astrocytoma according to GeneCards Suite gene sharing:

(show all 32)
idCompoundScoreTop Affiliating Genes
1olomoucine43 1210.5PCNA, TP53
28-oxo-dg439.5PCNA, TP53
3sulindac sulfide439.5PCNA, TP53
4temozolomide43 1210.5PCNA, TP53
5o6-methylguanine439.5TP53, PCNA
6aphidicolin439.5PCNA, TP53
7sulindac43 1210.5PCNA, TP53
8dutp439.5PCNA, TP53
9methylmethanesulfonate439.5TP53, PCNA
102-methoxyestradiol43 59 2411.5PCNA, TP53
11roscovitine439.5PCNA, TP53
12adpribose439.5PCNA, TP53
13hydroxyurea43 49 1211.5TP53, PCNA
14gemcitabine43 49 1211.5PCNA, TP53
15mitomycin c439.5PCNA, TP53
16thymidylate439.4PCNA, TP53
17cytarabine43 49 1211.4TP53, PCNA
18resveratrol43 59 24 1212.4PCNA, TP53
19caffeine43 28 2 49 24 1214.4PCNA, TP53
20camptothecin43 59 1211.4PCNA, TP53
21egcg439.4TP53, PCNA
22mg 13243 5910.4PCNA, TP53
23cyclophosphamide43 49 1211.4PCNA, TP53
245-aza-2deoxycytidine439.3PCNA, TP53
25arsenite43 2410.3TP53, PCNA
265fluorouracil439.3PCNA, TP53
27etoposide43 49 59 1212.2PCNA, TP53
28n acetylcysteine439.2PCNA, TP53
29butyrate439.1TP53, PCNA
30paraffin439.1PCNA, TP53
31tamoxifen43 49 28 1212.0PCNA, TP53
32paclitaxel43 49 1210.8PCNA, TP53

GO Terms for genes affiliated with Grade Iii Astrocytoma

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Cellular components related to Grade Iii Astrocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitochondrial matrixGO:00057599.0TP53, IDH2

Biological processes related to Grade Iii Astrocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell proliferationGO:00082839.1PCNA, TP53
2base-excision repairGO:00062849.0PCNA, TP53
3nucleotide-excision repairGO:00062898.8PCNA, TP53

Molecular functions related to Grade Iii Astrocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1receptor tyrosine kinase bindingGO:00309719.1PCNA, TP53

Products for genes affiliated with Grade Iii Astrocytoma

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  • Antibodies
  • Proteins
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  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Grade Iii Astrocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet