MCID: GRF002
MIFTS: 65

Graft Versus Host Disease malady

Rare diseases, Blood diseases categories
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Summaries for Graft Versus Host Disease

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Wikipedia:65 Graft-versus-host disease (GVHD) is a common complication following an allogeneic tissue transplant. It... more...

MalaCards based summary: Graft Versus Host Disease, also known as graft-versus-host disease, is related to acute graft versus host disease and leukemia. An important gene associated with Graft Versus Host Disease is IL2RA (interleukin 2 receptor, alpha), and among its related pathways are Immune response IL 12 signaling pathway and Hypertrophy Model. The drugs prednisone and prednisone pwdr and the compounds mycophenolate and lentinan have been mentioned in the context of this disorder. Affiliated tissues include bone, t cells and bone marrow, and related mouse phenotypes are digestive/alimentary and behavior/neurological.

Aliases & Classifications for Graft Versus Host Disease

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Graft Versus Host Disease, Aliases & Descriptions:

Name: Graft Versus Host Disease 30 44
 
Graft-Versus-Host Disease 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Blood diseases


Related Diseases for Graft Versus Host Disease

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Diseases in the Graft Versus Host Disease family:

Acute Graft Versus Host Disease Chronic Graft Versus Host Disease

Diseases related to Graft Versus Host Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 257)
idRelated DiseaseScoreTop Affiliating Genes
1acute graft versus host disease31.5IL2RB, IL2RA, IL18, IFNG, TNF
2leukemia31.1IL2RB, IL2RA, IFNG, TNF
3dermatitis30.9IL18, IFNG
4pneumonia30.9IL2RB, TNF
5lupus nephritis30.8IL2RA, IL18
6chronic lymphocytic leukemia30.7IL2RB, IL2RA
7severe combined immunodeficiency30.6IL2RB, IL2RA, IFNG
8cutaneous t cell lymphoma30.6IL2RB, IL2RA, IFNG
9hepatitis b30.5IL2RA, IL18, IFNG
10uveitis30.5IL2RA, IFNG, TNF
11monocytic leukemia30.4IFNG, TNF
12colitis30.4TNF, IFNG, IL18
13t-cell large granular lymphocyte leukemia30.4IL2RB, IL18
14anaplastic large cell lymphoma30.4IL2RA, IL2RB
15eosinophilia30.3IL2RB, IL2RA, IL18, IFNG
16psoriasis29.9IL2RA, IL18, IFNG, TNF
17atopic dermatitis29.6IL2RB, IL2RA, IL18, IFNG, TNF
18systemic lupus erythematosus29.6TNF, IFNG, IL18, IL2RA, IL2RB
19melanoma29.5IL2RB, IFNG, TNF
20multiple sclerosis29.4TNF, IFNG, IL18, IL2RA, IL2RB
21chronic graft versus host disease11.6
22hematopoietic stem cell transplantation11.3
23endotheliitis10.8
24hepatitis10.8
25myeloid leukemia10.7
26scleroderma10.7
27bronchiolitis obliterans10.7
28bronchiolitis10.7
29acute myeloid leukemia10.7
30graft-versus-host disease, protection against10.7
31acute lymphoblastic leukemia10.6
32myelodysplastic syndromes10.6
33lymphoblastic leukemia10.6
34vaginitis10.6
35acute leukemia10.6
36aplastic anemia10.6
37nephrotic syndrome10.6
38cytomegalovirus infection10.6
39lichen planus10.5
40pure red-cell aplasia10.5
41erythema multiforme10.5
42diarrhea10.5
43herpes simplex10.5
44myositis10.5
45lichen sclerosus10.5
46pleurisy10.5IL2RA
47periapical granuloma10.5IL2RA
48farmer's lung10.4IL2RA
49adult t-cell leukemia10.4
50chronic myeloid leukemia10.4

Graphical network of the top 20 diseases related to Graft Versus Host Disease:



Diseases related to graft versus host disease

Symptoms for Graft Versus Host Disease

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Drugs & Therapeutics for Graft Versus Host Disease

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Genetic Tests for Graft Versus Host Disease

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Anatomical Context for Graft Versus Host Disease

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MalaCards organs/tissues related to Graft Versus Host Disease:

32
Bone, T cells, Bone marrow, Liver, Skin, B cells, Endothelial, Myeloid, Eye, Lung, Colon, Monocytes, Kidney, Pancreas, Testes, Nk cells, Tongue, Breast, Whole blood, Lymph node, Thymus, Heart, Thyroid, Salivary gland, Neutrophil

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Graft Versus Host Disease:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Graft Versus Host Disease or affiliated genes

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MGI Mouse Phenotypes related to Graft Versus Host Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.4TNF, IFNG, IL18, IL2RA
2MP:00053868.0IL2RB, IL18, IFNG, TNF
3MP:00107717.7TNF, IFNG, IL18, IL2RB
4MP:00053977.7IL2RB, IL2RA, IL18, IFNG, TNF
5MP:00053877.6TNF, IFNG, IL18, IL2RA, IL2RB
6MP:00053787.6IL2RB, IL2RA, IL18, IFNG, TNF
7MP:00107687.4IL2RB, IL2RA, IL18, IFNG, TNF

Publications for Graft Versus Host Disease

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Articles related to Graft Versus Host Disease:

(show top 50)    (show all 1692)
idTitleAuthorsYear
1
Host-Derived CD8(+) Dendritic Cells Protect Against Acute Graft-versus-Host Disease after Experimental Allogeneic Bone Marrow Transplantation. (25132527)
2014
2
High day 28 ST2 levels predict for acute graft-versus-host disease and transplant-related mortality after cord blood transplantation. (25377785)
2014
3
Bilateral Sequential Dacryocystitis in a Patient With Graft-Versus-Host Disease. (25192327)
2014
4
Extracorporeal photopheresis as second-line treatment for acute graft-versus-host disease: Impact on six month freedom from treatment failure. (25150260)
2014
5
Inducible costimulator gene transduced bone marrow derived mesenchymal stem cells attenuate the severity of acute graft-versus-host disease in mouse models. (25203502)
2014
6
Positive impact of chronic graft-versus-host disease on the outcome of patients with de novo myelodysplastic syndrome after allogeneic hematopoietic cell transplantation: a single-center analysis of 115 patients. (24127668)
2013
7
Robust and cost effective expansion of human regulatory T cells highly functional in a xenograft model of graft-versus-host disease. (23242592)
2013
8
Limited benefit of pentostatin salvage therapy for steroid-refractory grade III-IV acute graft-versus-host disease. (24304375)
2013
9
Minor histocompatibility antigens as determinants for graft-versus-host disease after allogeneic haematopoietic stem cell transplantation. (23480177)
2013
10
Isomorphic sclerotic-type cutaneous chronic graft-versus-host disease: report and review of chronic graft-versus-host disease in a cutaneous immunocompromised district. (24318412)
2013
11
Absence of post-transplantation lymphoproliferative disorder after allogeneic blood or marrow transplantation using post-transplantation cyclophosphamide as graft-versus-host disease prophylaxis. (23871780)
2013
12
Inducible costimulator (ICOS) up-regulation on activated T cells in chronic graft-versus-host disease after dog leukocyte antigen-nonidentical hematopoietic cell transplantation: a potential therapeutic target. (23694952)
2013
13
Successful response to infliximab of recurrent pericardial graft versus host disease in a pediatric patient. (22580769)
2013
14
The use of novel Therakosa8c CellexAr for extracorporeal photopheresis in treatment of graft-versus-host disease in paediatric patients. (23961954)
2013
15
Mesenchymal stromal cells treatment attenuates dry eye in patients with chronic graft-versus-host disease. (23070118)
2012
16
Graft-versus-host disease disrupts intestinal microbial ecology by inhibiting Paneth cell production of I+-defensins. (22535662)
2012
17
Erythema ab igne as a differential diagnosis of chronic graft versus host disease (GVHD). (22834457)
2012
18
Oral cGVHD screening tests in the diagnosis of systemic chronic graft-versus-host disease. (21369795)
2012
19
Graft invariant natural killer T-cell dose predicts risk of acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation. (22371885)
2012
20
Improved outcomes using tacrolimus/sirolimus for graft-versus-host disease prophylaxis with a reduced-intensity conditioning regimen for allogeneic hematopoietic cell transplant as treatment of myelofibrosis. (19786111)
2010
21
Mesenchymal stromal cells for steroid-refractory acute graft-versus-host disease: a report of two cases. (20514533)
2010
22
Pre-engraftment syndrome after double-unit cord blood transplantation: a distinct syndrome not associated with acute graft-versus-host disease. (19857590)
2010
23
Graft-versus-host disease: regulation by microbe-associated molecules and innate immune receptors. (20042727)
2010
24
HBs seroconversion in a patient with acute hepatitis B treated with entecavir during immunosuppression against severe bronchiolitis obliterans in the course of chronic graft versus host disease. (20403727)
2010
25
Possible role of engraftment syndrome and autologous graft-versus-host disease in myelodysplastic syndrome after autologous stem cell transplantations: retrospective analysis and review of the literature. (20371446)
2010
26
Efficacy of bone marrow-derived mesenchymal stem cells in the treatment of sclerodermatous chronic graft-versus-host disease: clinical report. (19925878)
2010
27
A high risk of life-threatening infectious complications in mycophenolate mofetil treatment for acute or chronic graft-versus-host disease. (20217287)
2010
28
Pathogenetic role of tissue factor in endothelial-injury in graft-versus-host disease]. (19954621)
2009
29
Acute graft-versus-host disease: from the bench to the bedside. (19713461)
2009
30
Tacrolimus/Methotrexate versus cyclosporine/methotrexate as graft-versus-host disease prophylaxis in patients with severe aplastic anemia who received bone marrow transplantation from unrelated donors: results of matched pair analysis. (19896085)
2009
31
Low serum levels of total rabbit-IgG is associated with acute graft-versus-host disease after unrelated donor hematopoietic stem cell transplantation: results from a prospective study. (19589490)
2009
32
Elevated pretransplant ferritin is associated with a lower incidence of chronic graft-versus-host disease and inferior survival after myeloablative allogeneic haematopoietic stem cell transplantation. (19508292)
2009
33
Relation of an interleukin-23 receptor gene polymorphism to graft-versus-host disease after hematopoietic-cell transplantation. (18209723)
2008
34
Vascular endothelial growth factor gene polymorphisms may predict the risk of acute graft-versus-host disease following allogeneic transplantation: preventive effect of vascular endothelial growth factor gene on acute graft-versus-host disease. (19041064)
2008
35
U.K. consensus statement on the use of extracorporeal photopheresis for treatment of cutaneous T-cell lymphoma and chronic graft-versus-host disease. (18241274)
2008
36
Absence of cutaneous TNFalpha-producing CD4+ T cells and TNFalpha may allow for fibrosis rather than epithelial cytotoxicity in murine sclerodermatous graft-versus-host disease, a model for human scleroderma. (17429441)
2007
37
Alleviation of acute and chronic graft-versus-host disease in a murine model is associated with glucocerebroside-enhanced natural killer T lymphocyte plasticity. (17318079)
2007
38
Phase II study of pentostatin in patients with corticosteroid-refractory chronic graft-versus-host disease. (17878478)
2007
39
Facial rash mimicking cutaneous acute graft-versus-host disease after allogeneic stem cell transplantation for osteomyelofibrosis - was Demodex the culprit? (16474408)
2006
40
Diagnosis and treatment of chronic graft-versus-host disease. (16412791)
2006
41
A case of severe sclerodermatous chronic graft-versus-host disease: exposure to cement containing abundant silica may have been a relevant factor in scleroderma-like skin changes. (16043910)
2005
42
Protective conditioning for acute graft-versus-host disease. (16192477)
2005
43
Intestinal cryptosporidiosis mimicking acute graft-versus-host disease following matched unrelated hematopoietic stem cell transplantation. (15167618)
2004
44
Cytolytic effector mechanisms and gene expression in autologous graft-versus-host disease: distinct roles of perforin and Fas ligand. (14993881)
2004
45
TNF enhances CD4+ T cell alloproliferation, IFN-gamma responses, and intestinal graft-versus-host disease by IL-12-independent mechanisms. (12734353)
2003
46
Roles of interleukin-10 in acute graft-versus-host disease and graft rejection. (12875717)
2003
47
The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation. (10779417)
2000
48
Serum concentration of the soluble interleukin-2 receptor for monitoring acute graft-versus-host disease. (8640164)
1996
49
Antigenaemia during acute graft versus host disease. (7745106)
1995
50
Treatment of acute graft-versus-host disease with humanized anti-Tac: an antibody that binds to the interleukin-2 receptor. (8049447)
1994

Variations for Graft Versus Host Disease

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Expression for genes affiliated with Graft Versus Host Disease

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Expression patterns in normal tissues for genes affiliated with Graft Versus Host Disease

Search GEO for disease gene expression data for Graft Versus Host Disease.

Pathways for genes affiliated with Graft Versus Host Disease

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Pathways related to Graft Versus Host Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL2RA, IFNG
29.4IFNG, IL18
3
Show member pathways
9.4IFNG, IL18
49.4IL2RA, TNF
5
Show member pathways
thioredoxin pathway37
9.3TNF, IFNG
69.3TNF, IFNG
7
Show member pathways
9.3TNF, IFNG
89.3TNF, IFNG
9
Show member pathways
9.3IFNG, TNF
10
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.3IFNG, TNF
119.3TNF, IFNG
129.3TNF, IFNG
13
Show member pathways
Immune response MIF in innate immunity response60
9.3IFNG, TNF
149.3IFNG, TNF
159.3TNF, IFNG
169.3IL18, TNF
17
Show member pathways
9.3TNF, IL18
189.3TNF, IL18
19
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.2IL2RA, IL2RB
20
Show member pathways
Immune response IL 3 activation and signaling pathway60
9.2IL2RB, IL2RA
21
Show member pathways
IL2 signaling events mediated by STAT537
9.2IL2RB, IL2RA
229.0IL18, IL2RA, IFNG
23
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
8.9IL2RA, IFNG, TNF
24
Show member pathways
8.8IFNG, TNF, IL18
258.8IFNG, TNF, IL18
26
Show member pathways
IL27-mediated signaling events37
8.8IL18, IFNG, TNF
278.8IL18, IFNG, TNF
288.8IFNG, IL18, TNF
29
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
8.8TNF, IFNG, IL18
308.8TNF, IFNG, IL18
318.8IL18, IFNG, TNF
328.8TNF, IL18, IFNG
33
Show member pathways
IL-2 Signaling pathway37
8.7IL2RA, IFNG, IL2RB
34
Show member pathways
Type III interferon signaling37
8.7IFNG, IL2RA, IL2RB
358.7IL2RB, IL2RA, IFNG
36
Show member pathways
8.7IL18, IL2RA, IL2RB
37
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
8.6TNF, IL2RA, IL2RB
388.6TNF, IL2RB, IL2RA
39
Show member pathways
8.4TNF, IL2RA, IFNG, IL18
40
Show member pathways
Immune response IL 12 induced IFN gamma production60
8.2IL2RA, IL18, IFNG, IL2RB
41
Show member pathways
8.2IL18, IFNG, IL2RB, IL2RA
42
Show member pathways
Ras signaling in the CD4+ TCR pathway37
8.1TNF, IL2RB, IFNG, IL2RA
43
Show member pathways
8.1IL2RA, IFNG, IL2RB, TNF
44
Show member pathways
8.1TNF, IFNG, IL2RA, IL2RB
45
Show member pathways
8.1IL2RA, IL2RB, TNF, IL18
46
Show member pathways
8.1IL2RB, IL18, IL2RA, TNF
47
Show member pathways
8.1TNF, IL18, IL2RA, IL2RB
48
Show member pathways
7.5IL2RB, TNF, IFNG, IL18, IL2RA
49
Show member pathways
7.5IFNG, IL18, IL2RB, TNF, IL2RA
50
Show member pathways
7.5IFNG, IL18, IL2RB, IL2RA, TNF

Compounds for genes affiliated with Graft Versus Host Disease

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Compounds related to Graft Versus Host Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 126)
idCompoundScoreTop Affiliating Genes
1mycophenolate449.5IL2RA, IL2RB
2lentinan449.5IL2RA, IL2RB
3tuberculin449.4IL2RA, IFNG, IL18
4thymoglobulin449.3IL2RB, IL2RA
5gold sodium thiomalate449.3IFNG, IL2RA, TNF
6il-12449.2TNF, IL18, IFNG
7indoleamine449.2IL18, TNF, IFNG
8imiquimod44 61 28 1112.2TNF, IFNG, IL18
9gm-csf44 2810.1TNF, IFNG, IL18
10polyinosinic-polycytidylic acid449.1IFNG, TNF, IL18
11denileukin diftitox44 50 1111.1IL2RA, IL2RB
12poly(i-c)449.1TNF, IFNG, IL18
13tarc449.0TNF, IL18, IFNG
14levamisole44 1110.0IL2RB, IL2RA, IL18
15interferon gamma449.0TNF, IFNG
16chloroquine44 2 50 28 1113.0IL2RA, TNF, IL18
17ccl344 2810.0IL18, IFNG, TNF
18pdtc449.0TNF, IFNG, IL18
19atorvastatin44 50 28 24 1112.9TNF, IL18, IL2RA
20simvastatin44 50 61 28 24 1113.8TNF, IFNG, IL18
21natalizumab44 119.8IFNG, TNF, IL18, IL2RA
22thalidomide44 50 61 1111.7IL2RA, IL18, IFNG, TNF
23indomethacin44 28 61 1111.7TNF, IFNG, IL2RA, IL18
24con a448.6IL2RB, IFNG, IL18, IL2RA
25ifn-alpha448.6IFNG, IL18, IL2RA, IL2RB
26okt3448.5IFNG, TNF, IL2RB, IL2RA
272,5-oligoadenylate448.5TNF, IL2RB, IL2RA, IFNG
28ivig448.5IFNG, TNF, IL2RB, IL2RA
29rapamycin448.4IL2RA, IL18, IFNG, IL2RB
30etanercept44 50 1110.4TNF, IFNG, IL18, IL2RB
31methotrexate50 44 1110.4IL2RB, IL2RA, TNF, IL18
32n acetylcysteine448.4IL18, IL2RA, IL2RB, TNF
33endotoxin448.4TNF, IFNG, IL2RB, IL18
34genistein44 28 61 2 24 1113.3IFNG, IL2RA, IL2RB, TNF
35cycloheximide448.1IFNG, IL18, IL2RB, TNF
36il 10448.0TNF, IL2RA, IL2RB, IFNG, IL18
37mycophenolate mofetil44 50 1110.0TNF, IFNG, IL18, IL2RA, IL2RB
38infliximab44 50 1110.0IL2RB, IL18, IFNG, TNF, IL2RA
39pentoxifylline44 119.0TNF, IFNG, IL2RB, IL2RA, IL18
40neopterin448.0TNF, IL2RB, IFNG, IL18, IL2RA
41prednisolone44 28 1110.0IL2RA, IFNG, IL2RB, IL18, TNF
42ionomycin448.0IFNG, IL18, IL2RA, TNF, IL2RB
43tacrolimus44 50 1110.0IL2RB, IL2RA, TNF, IL18, IFNG
44rantes448.0TNF, IL2RB, IL18, IFNG, IL2RA
45histamine44 28 249.9IFNG, IL2RB, IL2RA, IL18, TNF
46cyclosporin a44 28 619.9IL18, IL2RB, IFNG, TNF, IL2RA
47pge2447.9IL18, TNF, IFNG, IL2RA, IL2RB
48thymidine44 248.9IL18, IFNG, IL2RA, IL2RB, TNF
49dexamethasone44 50 28 1110.9TNF, IFNG, IL2RB, IL18, IL2RA
50vegf447.9IL2RB, TNF, IFNG, IL18, IL2RA

GO Terms for genes affiliated with Graft Versus Host Disease

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Cellular components related to Graft Versus Host Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.1IL2RB, IL2RA, IFNG, TNF

Biological processes related to Graft Versus Host Disease according to GeneCards/GeneDecks:

(show all 19)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of activated T cell proliferationGO:0421049.8IL2RA, IL18
2positive regulation of vitamin D biosynthetic processGO:0605579.7TNF, IFNG
3positive regulation of calcidiol 1-monooxygenase activityGO:0605599.7TNF, IFNG
4positive regulation of chemokine biosynthetic processGO:0450809.6IFNG, TNF
5positive regulation of membrane protein ectodomain proteolysisGO:0510449.6IFNG, TNF
6negative regulation of growth of symbiont in hostGO:0441309.6IFNG, TNF
7positive regulation of NF-kappaB import into nucleusGO:0423469.6TNF, IL18
8positive regulation of osteoclast differentiationGO:0456729.6IFNG, TNF
9protein import into nucleus, translocationGO:0000609.6IFNG, TNF
10lipopolysaccharide-mediated signaling pathwayGO:0316639.6TNF, IL18
11positive regulation of nitric oxide biosynthetic processGO:0454299.5TNF, IFNG
12cellular response to organic cyclic compoundGO:0714079.5IL18, TNF
13extrinsic apoptotic signaling pathwayGO:0971919.5TNF, IFNG
14positive regulation of interferon-gamma productionGO:0327299.4TNF, IL18
15humoral immune responseGO:0069599.4IFNG, TNF
16response to virusGO:0096159.3IFNG, TNF
17MAPK cascadeGO:0001659.2IL18, TNF
18regulation of insulin secretionGO:0507969.0IFNG, TNF
19apoptotic processGO:0069158.9TNF, IFNG, IL2RA

Molecular functions related to Graft Versus Host Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-2 receptor activityGO:0049119.1IL2RB, IL2RA
2interleukin-2 bindingGO:0199768.9IL2RB, IL2RA
3cytokine activityGO:0051258.8IL18, IFNG, TNF

Products for genes affiliated with Graft Versus Host Disease

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Sources for Graft Versus Host Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet