MCID: GRF002
MIFTS: 65

Graft Versus Host Disease malady

Summaries for Graft Versus Host Disease

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63Wikipedia, 32MalaCards
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Wikipedia:63 Graft-versus-host disease (GVHD) is a common complication following an allogeneic tissue transplant. It... more...

MalaCards: Graft Versus Host Disease, also known as graft-versus-host disease, is related to leukemia and skin disease. An important gene associated with Graft Versus Host Disease is IL2RA (interleukin 2 receptor, alpha), and among its related pathways are Akt Signaling and Allograft rejection. The compounds tyrosine and rapamycin have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and bone marrow, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Graft Versus Host Disease

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30LifeMap Discovery™, 44Novoseek
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Aliases & Descriptions:

graft versus host disease 30 44
graft-versus-host disease 44


Related Diseases for Graft Versus Host Disease

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17GeneCards, 18GeneDecks
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Diseases in the Graft Versus Host Disease family:

Acute Graft Versus Host Disease Chronic Graft Versus Host Disease

Diseases related to Graft Versus Host Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 397)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.7CENPF, THPO, HMHA1, KIR3DL1, IL2, IL2RB
2skin disease31.5IL18, IL10, TNF, IFNG
3acute leukemia31.4THPO, IL2, CSF3
4t-cell leukemia31.1IL2, IL2RB, IL2RA, CD28, LTA, FASLG
5hepatitis31.1THPO, IL2RB, FASLG, GZMB
6myeloid leukemia31.1THPO, KIR3DL1, LTA, CSF3
7chronic graft versus host disease30.9CD28, CSF3
8vascular disease30.9IL2, IL10, FASLG, TNF
9acute graft versus host disease30.9THPO, HMHA1, KIR3DL1, IL2, IL2RB, IL1R1
10eosinophilia30.8IL2, IL2RB, IL18, IL10, IL2RA, IFNG
11chronic lymphocytic leukemia30.8THPO, IL2, IL2RA, CD28, LTA, CCR5
12severe combined immunodeficiency30.8IL2, IL2RB, IL15, IL2RA, IFNG
13aplastic anemia30.8THPO, FASLG, CSF3, GZMB, IFNG
14pneumonia30.8IL2RB, IL10, TNF, CSF3
15chronic myeloid leukemia30.8THPO, KIR3DL1, CSF3, GZMB
16myeloma30.7IL2, IL15, CD28, LTA, FASLG, CSF3
17cutaneous t cell lymphoma30.7IL2, IL2RB, IL15, IL2RA, GZMB, IFNG
18dermatitis30.7IL18, GZMB, IFNG
19multiple myeloma30.7CSF3
20lichen planus30.7GZMB
21nephrotic syndrome30.7IL2RA
22diarrhea30.7IL2
23thrombocytopenia30.6THPO, IL2, IL1R1, CSF3
24thymoma30.6IL2, IL1R1, TNFRSF4
25pancytopenia30.6THPO, IL2RA, CSF3
26myositis30.6CD28, GZMB
27systemic lupus erythematosus30.5IL2, IL2RB, IL1R1, IL18, IL10, IL15
28breast cancer30.5CENPF, THPO, KIR3DL1, IL2, IL1R1, IL15
29atopic dermatitis30.5IL2, IL2RB, IL18, IL10, IL2RA, LTA
30uveitis30.5IL1R1, IL10, IL2RA, LTA, TNF, IFNG
31hepatitis b30.5IL18, IL10, IL2RA, IFNG, CCR5
32glomerulonephritis30.5IL1R1, CD28, CCR5
33neutropenia30.5THPO, CSF3, GZMB
34sarcoma30.5THPO, IL2, IL1R1
35lupus erythematosus30.5IL18
36aspergillosis30.5IFNG
37dermatomyositis30.5CD28
38myelofibrosis30.5THPO, CSF3
39multiple sclerosis30.3THPO, IL2, IL2RB, IL1R1, IL18, IL10
40melanoma30.3KIR3DL1, IL2, IL2RB, IL10, IL15, CD28
41psoriasis30.3KIR3DL1, IL2, IL1R1, IL18, IL10, IL15
42lymphopenia30.3IL2, IL2RB, IL18, IL10, IL15, IL2RA
43encephalomyelitis30.3IL2, IL10, LTA, FASLG, TNFRSF4, TNF
44t-cell large granular lymphocyte leukemia30.3IL2, IL2RB, IL18, FASLG, GZMB
45anaplastic large cell lymphoma30.3IL2RB, IL2RA, GZMB
46obesity30.3IL18, IL15, TNF
47acute pancreatitis30.3IL1R1, IL18, IL10
48cervical cancer30.3IL1R1, IL15
49monocytic leukemia30.3IL1R1, TNF, IFNG
50thyroiditis30.3FASLG

Graphical network of the top 20 diseases related to Graft Versus Host Disease:



Diseases related to graft versus host disease

Clinical Features for Graft Versus Host Disease

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Drugs & Therapeutics for Graft Versus Host Disease

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Graft Versus Host Disease

Drug clinical trials:

Search ClinicalTrials for Graft Versus Host Disease

Search NIH Clinical Center for Graft Versus Host Disease

Search CenterWatch for Graft Versus Host Disease

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Graft Versus Host Disease cell therapies at LifeMap Discovery.

Genetic Tests for Graft Versus Host Disease

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Anatomical Context for Graft Versus Host Disease

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Graft Versus Host Disease:

32
T cells, Bone, Bone marrow, Skin, Liver, B cells, Endothelial, Myeloid, Eye, Lung, Colon, Monocytes, Testes, Kidney, Nk cells, Tongue, Pancreas, Breast, Thyroid, Heart, Salivary gland, Spleen, Lymph node, Whole blood, Thymus

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Graft Versus Host Disease:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Graft Versus Host Disease or affiliated genes

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36MGI
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Publications for Graft Versus Host Disease

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50PubMed
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Articles related to Graft Versus Host Disease:

(show top 50)    (show all 1669)
idTitleAuthorsYear
1
Adult adherent stromal cells in the management of graft-versus-host disease. (24397853)
2014
2
Successful use of extracorporeal membrane oxygenation for respiratory failure in pulmonary chronic graft-versus-host disease. (24281123)
2014
3
A safety and feasibility study with platelet lysate expanded bone marrow mesenchymal stromal cells for the treatment of acute graft-versus-host disease in Brazil. (23844820)
2013
4
IgM anti-recipient ABO antibodies predict acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation. (23661033)
2013
5
Pre-engraftment syndrome after unrelated cord blood transplantation: a predictor of engraftment and acute graft-versus-host disease. (23380345)
2013
6
c-Rel is an essential transcription factor for the development of acute graft-versus-host disease in mice. (23716202)
2013
7
Graft invariant natural killer T-cell dose predicts risk of acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation. (22371885)
2012
8
Neuropathy in chronic graft-versus-host disease caused by donor T cells. (22987708)
2012
9
Overlap subtype of chronic graft-versus-host disease is associated with an adverse prognosis, functional impairment, and inferior patient-reported outcomes: a Chronic Graft-versus-Host Disease Consortium study. (22058206)
2012
10
Novel regulatory therapies for prevention of Graft-versus-host disease. (22587383)
2012
11
Loss of endothelial thrombomodulin predicts response to steroid therapy and survival in acute intestinal graft-versus-host disease. (22689672)
2012
12
Blockade of Vascular Endothelial Growth Factor (VEGF) Aggravates the Severity of Acute Graft-versus-host Disease (GVHD) after Experimental Allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT). (22346777)
2011
13
Biomarkers in chronic graft-versus-host disease. (21668397)
2011
14
Association between serum high-molecular-weight adiponectin level and the severity of chronic graft-versus-host disease in allogeneic stem cell transplantation recipients. (21258011)
2011
15
Regulation of acute graft-versus-host disease by human umbilical cord blood derived stromal cells in haploidentical stem cell transplantation in mice through very late activation antigen-4. (21310663)
2011
16
Low doses of natural killer T cells provide protection from acute graft-versus-host disease via an IL-4-dependent mechanism. (21258007)
2011
17
Adoptive therapy by transfusing expanded donor murine natural killer T cells can suppress acute graft-versus-host disease in allogeneic bone marrow transplantation. (19788510)
2010
18
Polymorphisms in the base excision repair pathway and graft-versus-host disease. (20574454)
2010
19
Invasive zygomycosis in patients with graft-versus-host disease after allogeneic stem cell transplantation. (20002357)
2010
20
Glucocorticoid-refractory acute graft-versus-host disease. (20096359)
2010
21
Prevention of murine acute graft-versus-host disease by recipient-derived paired immunoglobulin-like receptor B lentivirus-transfected dendritic cells. (20881379)
2010
22
Possible association between obesity and posttransplantation complications including infectious diseases and acute graft-versus-host disease. (19135945)
2009
23
Bone marrow transplantation: new approaches to immunosuppression and management of acute graft-versus-host disease. (19242239)
2009
24
Induction of lethal graft-versus-host disease by anti-CD137 monoclonal antibody in mice prone to chronic graft-versus-host disease. (19203721)
2009
25
U.K. consensus statement on the use of extracorporeal photopheresis for treatment of cutaneous T-cell lymphoma and chronic graft-versus-host disease. (18241274)
2008
26
Murine bone marrow derived stromal progenitor cells fail to prevent or treat acute graft-versus-host disease. (18318768)
2008
27
Etanercept plus methylprednisolone as initial therapy for acute graft-versus-host disease. (18042798)
2008
28
CXCL10-CXCR3 interactions play an important role in the pathogenesis of acute graft-versus-host disease in the skin following allogeneic stem-cell transplantation. (17766680)
2007
29
Advances in the understanding of acute graft-versus-host disease. (17359368)
2007
30
Prediction of graft-versus-host disease in humans by donor gene-expression profiling. (17378698)
2007
31
Ocular complications in a child with acute graft-versus-host disease following cord blood stem cell transplantation: therapeutic challenges. (16879579)
2006
32
Histopathologic diagnosis of chronic graft-versus-host disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. Pathology Working Group Report. (16399567)
2006
33
Sclerodermatous chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation: incidence, predictors and outcome. (16461315)
2006
34
Preferential involvement of Tim-3 in the regulation of hepatic CD8+ T cells in murine acute graft-versus-host disease. (16982862)
2006
35
Acute graft-versus-host disease after liver transplantation diagnosed by fluorescent in situ hybridization testing of skin biopsy specimens. (17010745)
2006
36
Relationship between CCR5 and acute graft-versus-host disease in murine bone marrow transplantation]. (17096892)
2006
37
Human leucocyte antigen-identical haematopoietic stem cell transplantation in major histocompatiblity complex class II immunodeficiency: reduced survival correlates with an increased incidence of acute graft-versus-host disease and pre-existing viral infections. (16848795)
2006
38
Influence of the intensity of the conditioning regimen on the characteristics of acute and chronic graft-versus-host disease after allogeneic transplantation. (16042689)
2005
39
CCR6 regulates CD4+ T-cell-mediated acute graft-versus-host disease responses. (15774622)
2005
40
Extensive chronic graft-versus-host disease of skin successfully treated with thalidomide. (16515241)
2005
41
The pathophysiology of acute graft-versus-host disease. (15882431)
2005
42
Intestinal cryptosporidiosis mimicking acute graft-versus-host disease following matched unrelated hematopoietic stem cell transplantation. (15167618)
2004
43
Killer cell inhibitory receptors involved in graft-versus-host disease and graft-versus-leukemia effect in allogeneic hematopoietic stem cell transplantation - review. (15157342)
2004
44
Acute graft-versus-host disease: pathophysiology, clinical manifestations, and management. (15372473)
2004
45
Treatment of graft-versus-host disease after liver transplantation with basiliximab followed by bowel resection. (12859540)
2003
46
Treatment of pure red cell aplasia after major ABO-incompatible peripheral blood stem cell transplantation by induction of chronic graft-versus-host disease. (12379896)
2002
47
Soluble interleukin-2 receptor concentration as a biochemical indicator for acute graft-versus-host disease after allogeneic bone marrow transplantation. (10894361)
2000
48
Correlation between disparity for the minor histocompatibility antigen HA-1 and the development of acute graft-versus-host disease after allogeneic marrow transplantation. (10515896)
1999
49
Nitric oxide formation as predictive parameter for acute graft-versus-host disease after human allogeneic bone marrow transplantation. (8525517)
1995
50
Treatment of steroid-resistant acute graft-versus-host disease with an anti-IL-2-receptor monoclonal antibody (BT 563) in children who received T cell-depleted, partially matched, related bone marrow transplants. (8054909)
1994

Genetic Variations for Graft Versus Host Disease

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Expression for genes affiliated with Graft Versus Host Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Graft Versus Host Disease

Search GEO for disease gene expression data for Graft Versus Host Disease.

Pathways for genes affiliated with Graft Versus Host Disease

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Sources:
51QIAGEN, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems, 53Reactome, 4Cell Signaling Technology
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Pathways related to Graft Versus Host Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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11.7TNFRSF4, TNF, CSF3, CCR5, IL18, IL2
2
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11.3IL15, IL10, IL18, IL2RA, IFNG, GZMB
3
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11.3IFNG, IL2RB, TNF, FASLG, LTA, CD28
4
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11.2CCR5, IFNG, GZMB, IL2RA, FASLG, IL18
5
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11.2IL2RB, IFNG, GZMB, TNF, FASLG, IL2RA
6
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11.2IL2RB, IL1R1, IL15, IL2RA, CD28, CCR5
711.2IFNG, GZMB, TNF, IL2, IL2RB, IL2RA
8
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11.2LTA, CCR5, CD28, TNFRSF4, THPO, IL2RB
9
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11.1IFNG, CD28, IL2RB, IL2RA, IL18, IL1R1
10
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11.1IL2, TNF, THPO, IL2RB, IL15, IL2RA
1111.1IL2RB, IL2, IFNG, IL10, IL2RA, CSF3
12
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11.1CD28, FASLG, TNFRSF4, CSF3, CCR5, IL2RA
1311.1IL2, IL18, TNF, IFNG, IL15, LTA
14
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11.1IL2, IL18, IL10, IFNG, TNF, LTA
15
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11.0IL2RA, IL2, IL2RB, IFNG, TNF, IL1R1
16
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11.0IL2, IL2RB, IL1R1, IL2RA, IFNG, IL18
17
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11.0KIR3DL1, GZMB, IFNG, TNF, FASLG, IL2
1811.0IL2RA, GZMB, IL2, IL2RB, IL10, FASLG
19
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11.0IL2, IL10, TNF, IFNG, CCR5, CD28
20
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10.9TNF, FASLG, IFNG, IL2RA, IL2
21
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10.9GZMB, TNF, FASLG, LTA, IL1R1
2210.9IL18, IL10, FASLG, TNF, IFNG
23
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10.9IL18, IL1R1, IL2RB, IL2, IL2RA
24
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10.9IL2RA, IL2, LTA, FASLG, IL2RB
25
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10.9IL2, IFNG, TNF, FASLG, IL10
2610.9THPO, CSF3, TNF, IL2RA, IL1R1
2710.9IL2RA, FASLG, CSF3, IL2, IL2RB
2810.9IL15, IL2RA, IL2RB, IL2, IL1R1
2910.9IL10, LTA, IL2, TNFRSF4, IFNG
30
Development PDGF signaling via STATs and NF-kB
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10.9TNF, IFNG, IL10, IL2, IL18
3110.9IL2, IL2RB, IL2RA, CD28, IFNG
32
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10.9LTA, THPO, IL2, IL2RA, IL2RB
3310.9IL2RA, IL18, IL2, CD28, IFNG
34
Immune response Bacterial infections in normal airways
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10.8FASLG, IL1R1, IFNG, TNF
35
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10.8LTA, TNF, TNFRSF4, IL1R1
3610.8IFNG, TNF, IL10, IL1R1
37
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10.8TNF, IL1R1, LTA, FASLG
38
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10.8IL2RB, IFNG, IL2RA, IL2
39
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10.8TNF, IL1R1, THPO, LTA
40
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10.8CCR5, TNF, FASLG, LTA
4110.8LTA, TNF, IL1R1, CD28
4210.8IL2, CD28, IL2RA, IL2RB
43
Hide members
10.8IL2, IL2RB, IL2RA, CD28
4410.7IL1R1, TNF, IL2
4510.7TNF, IL2, IFNG
46
Hide members
10.7CD28, IL1R1, GZMB
47
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10.7IFNG, LTA, CCR5
4810.7IL18, CD28, IL15
49
Hide members
10.6IL18, CCR5
5010.6IL18

Compounds for genes affiliated with Graft Versus Host Disease

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Graft Versus Host Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 188)
idCompoundScoreTop Affiliating Genes
1tyrosine4412.1KIR3DL1, IL2, CSF3, CCR5, IL15, GZMB
2rapamycin4412.0IL2RB, IL2, THPO, IL1R1, IL18, CCR5
3ionomycin4411.9IL18, IL10, IL2RB, IL2, IL15, LTA
4thymidine44 2412.9IFNG, CSF3, TNF, FASLG, IL2RA, IL15
5rantes4411.9THPO, IL2, IFNG, GZMB, CSF3, TNF
6vegf4411.9GZMB, CSF3, TNF, FASLG, LTA, IL2RA
7tacrolimus44 49 1113.9IL2RA, IL15, IL10, IL18, IL2RB, IL2
8il 104411.9CCR5, IL2, IFNG, TNF, LTA, IL2RA
9retinoic acid44 2412.8TNF, THPO, CSF3, IL2RB, CCR5, IL1R1
10cyclosporin a44 28 5913.8GZMB, CSF3, TNFRSF4, LTA, CD28, IL2RA
11neopterin4411.7LTA, TNF, GZMB, IFNG, IL18, IL2
12infliximab44 49 1113.7IL10, IL2RA, LTA, TNF, IL15, IL1R1
13histamine44 28 2413.7THPO, CCR5, TNF, IL2RA, IL15, IL10
14nitric oxide44 11 2413.7LTA, IL15, GZMB, IL10, IL18, IL1R1
15okt34411.6IL2RB, IL2, IL10, IL15, IFNG, TNF
16methotrexate44 49 1113.6IL18, CSF3, TNF, FASLG, IL2RA, IL15
17etanercept44 49 1113.6IL2RB, IL1R1, TNF, IL18, IL10, IL15
18ccl344 2812.6TNF, CSF3, IFNG, CCR5, IL10, IL18
19rituximab44 49 1113.5IL2RA, IL1R1, CSF3, IL10, IL15, TNF
20thalidomide44 49 59 1114.5IL18, IL10, IL2RA, FASLG, TNF, IFNG
21il-124411.5IL2, IL1R1, IL18, IL10, IL15, TNF
22cyclophosphamide44 49 1113.5FASLG, IL2RA, CSF3, IL15, IL2, IL2RB
23con a4411.5IL2RA, CD28, IFNG, IL2RB, IL10, IL18
24mycophenolate mofetil44 49 1113.4IFNG, IL2RB, IL2, IL10, IL2RA, CSF3
25ifn-alpha4411.4IL2RB, IL18, IL10, IL2RA, FASLG, IL2
265fluorouracil4411.4IFNG, FASLG, CSF3, IL2RA, IL15, IL18
27chloroquine44 2 49 28 1115.4IL1R1, IL2, IL18, IL10, IL15, IL2RA
28prednisolone44 28 1113.3GZMB, LTA, IL2RA, IL1R1, IL2RB
29dexamethasone44 49 28 1114.3IL1R1, IL15, LTA, FASLG, GZMB
30polyinosinic-polycytidylic acid4411.3IL18, IL10, IL15, IL2, IFNG, TNF
31gm-csf44 2812.3IFNG, TNF, IL10, THPO
32ivig4411.3CCR5, IFNG, IL1R1, IL2RB
33pentoxifylline44 1112.2LTA, IL18, IL1R1, IL2RB
34alpha-galactosylceramide4411.2IL15, IFNG, GZMB, IL2, IL10
35tgf beta14411.2TNF, IL18, IL10, THPO, IL15, LTA
36cycloheximide4411.2IL18, LTA, FASLG, IL2RB
37ribavirin44 49 1113.2IL10, IL2, IL18, CSF3, IFNG, CCR5
38tuberculin4411.1IL15, IL10, IL18, IFNG, IL2RA
39gold sodium thiomalate4411.1IFNG, TNF, IL2RA, IL1R1, IL2
40natalizumab44 1112.1IL10, IL2RA, IFNG, TNF, IL18
412,5-oligoadenylate4411.1TNF, IL2, IL2RB, IL2RA
42actinomycin d4411.1FASLG, TNF, THPO, IL2, IL1R1, LTA
43endotoxin4411.0FASLG, CSF3
44imiquimod44 28 59 1114.0TNF, IL10, IL18, IFNG, FASLG
45pge24411.0IL2
46lipoteichoic acid4410.9IL1R1, IL10, LTA, TNF, IL18
47indomethacin44 59 28 1113.9IL1R1
48chromium4410.9KIR3DL1, IL2RB, GZMB
49interferon gamma4410.8TNF, IL2, IL10, IFNG
50ctla4-ig4410.5IL2RB, IL15, CD28, IL2

GO Terms for genes affiliated with Graft Versus Host Disease

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16Gene Ontology
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Cellular components related to Graft Versus Host Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588711.2TNF, TNFRSF4, FASLG, CD28, IL15, IL1R1
2external side of plasma membraneGO:00989711.1IL2RB, CCR5, IFNG, TNF, TNFRSF4, FASLG
3extracellular spaceGO:00561511.0IFNG, CSF3, TNF, FASLG, LTA, IL15

Biological processes related to Graft Versus Host Disease according to GeneCards/GeneDecks:

(show all 35)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.7KIR3DL1, CCR5, CSF3, TNFRSF4, FASLG, IL2RA
2cell-cell signalingGO:00726711.5CCR5, FASLG, LTA, IL15, IL10, IL18
3inflammatory responseGO:00695411.4CCR5, TNF, TNFRSF4, IL15, IL10, IL18
4apoptotic processGO:00691511.3IFNG, GZMB, TNF, FASLG, LTA, IL2RA
5cell surface receptor signaling pathwayGO:00716611.3CCR5, IFNG, CD28, IL2RA, IL1R1
6response to drugGO:04249311.3IFNG, TNF, LTA, IL10, CENPF
7positive regulation of transcription from RNA polymerase II promoterGO:04594411.2IL2, IL10, CD28, TNF, CSF3, IFNG
8negative regulation of growth of symbiont in hostGO:04413011.2IL10, LTA, TNF, IFNG
9positive regulation of interferon-gamma productionGO:03272911.2TNF, LTA, IL18, IL2
10humoral immune responseGO:00695911.2IFNG, TNF, LTA, CD28
11cellular response to lipopolysaccharideGO:07122211.2CCR5, IFNG, CSF3, IL10
12positive regulation of isotype switching to IgG isotypesGO:04830411.1IFNG, CD28, IL2
13positive regulation of tissue remodelingGO:03410511.1IL15, IL18, IL2
14positive regulation of interleukin-17 productionGO:03274011.1IL2, IL18, IL15
15positive regulation of activated T cell proliferationGO:04210411.1IL2, IL18, IL2RA
16positive regulation of neuron apoptotic processGO:04352511.0IL18, FASLG, TNF
17positive regulation of vitamin D biosynthetic processGO:06055711.0IFNG, TNF
18positive regulation of T cell proliferationGO:04210211.0IL15, CD28, IFNG
19regulation of T cell homeostatic proliferationGO:04601311.0IL2RA, IL2
20positive regulation of chronic inflammatory response to antigenic stimulusGO:00287611.0TNF, LTA
21positive regulation of inflammatory responseGO:05072911.0IL15, IL18, IL2
22positive regulation of calcidiol 1-monooxygenase activityGO:06055911.0IFNG, TNF
23activation of necroptosis by extracellular signalsGO:06055511.0TNF, FASLG
24receptor biosynthetic processGO:03280011.0TNF, IL10
25type 2 immune responseGO:04209210.9IL10, IL18
26necrotic cell deathGO:07026510.9TNF, FASLG
27negative regulation of cytokine secretion involved in immune responseGO:00274010.8TNF, IL10
28MAPK cascadeGO:00016510.8CCR5, TNF, IL18
29positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.8LTA, TNF
30positive regulation of natural killer cell proliferationGO:03281910.8IL18, IL15
31positive regulation of MHC class II biosynthetic processGO:04534810.7IL10, IFNG
32positive regulation of immunoglobulin secretionGO:05102410.6IL2, TNFRSF4
33lymph node developmentGO:04853510.6IL15, LTA
34positive regulation of chemokine biosynthetic processGO:04508010.6IFNG, TNF
35positive regulation of apoptotic processGO:04306510.5IL2RA, LTA, FASLG, TNF

Molecular functions related to Graft Versus Host Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512511.4THPO, IFNG, CSF3, TNF, FASLG, LTA
2tumor necrosis factor receptor bindingGO:00516410.8TNF, FASLG, LTA
3protease bindingGO:00202010.7IL1R1, CD28, TNF
4interleukin-2 receptor activityGO:00491110.7IL2RB, IL2RA
5interleukin-2 bindingGO:01997610.6IL2RB, IL2RA
6growth factor activityGO:00808310.5CSF3, IL10, IL2, THPO

Products for genes affiliated with Graft Versus Host Disease

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Sources for Graft Versus Host Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet