MCID: GRF002
MIFTS: 65

Graft Versus Host Disease malady

Summaries for Graft Versus Host Disease

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63Wikipedia, 32MalaCards
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Wikipedia:63 Graft-versus-host disease (GVHD) is a common complication following an allogeneic tissue transplant. It... more...

MalaCards: Graft Versus Host Disease, also known as graft-versus-host disease, is related to leukemia and skin disease. An important gene associated with Graft Versus Host Disease is IL2RA (interleukin 2 receptor, alpha), and among its related pathways are Akt Signaling and Allograft rejection. The compounds tyrosine and rapamycin have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone and bone marrow, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Graft Versus Host Disease

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30LifeMap Discovery™, 44Novoseek
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Aliases & Descriptions:

graft versus host disease 30 44
graft-versus-host disease 44


Related Diseases for Graft Versus Host Disease

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17GeneCards, 18GeneDecks
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Diseases in the Graft Versus Host Disease family:

Acute Graft Versus Host Disease Chronic Graft Versus Host Disease

Diseases related to Graft Versus Host Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 397)
idRelated DiseaseScoreTop Affiliating Genes
1leukemia31.7CENPF, THPO, HMHA1, KIR3DL1, IL2, IL2RB
2skin disease31.5IL18, IL10, TNF, IFNG
3acute leukemia31.4THPO, IL2, CSF3
4t-cell leukemia31.1IL2, IL2RB, IL2RA, CD28, LTA, FASLG
5hepatitis31.1THPO, IL2RB, FASLG, GZMB
6myeloid leukemia31.1THPO, KIR3DL1, LTA, CSF3
7chronic graft versus host disease30.9CD28, CSF3
8vascular disease30.9IL2, IL10, FASLG, TNF
9acute graft versus host disease30.9THPO, HMHA1, KIR3DL1, IL2, IL2RB, IL1R1
10eosinophilia30.8IL2, IL2RB, IL18, IL10, IL2RA, IFNG
11chronic lymphocytic leukemia30.8THPO, IL2, IL2RA, CD28, LTA, CCR5
12severe combined immunodeficiency30.8IL2, IL2RB, IL15, IL2RA, IFNG
13aplastic anemia30.8THPO, FASLG, CSF3, GZMB, IFNG
14pneumonia30.8IL2RB, IL10, TNF, CSF3
15chronic myeloid leukemia30.8THPO, KIR3DL1, CSF3, GZMB
16myeloma30.7IL2, IL15, CD28, LTA, FASLG, CSF3
17cutaneous t cell lymphoma30.7IL2, IL2RB, IL15, IL2RA, GZMB, IFNG
18dermatitis30.7IL18, GZMB, IFNG
19multiple myeloma30.7CSF3
20lichen planus30.7GZMB
21nephrotic syndrome30.7IL2RA
22diarrhea30.7IL2
23thrombocytopenia30.6THPO, IL2, IL1R1, CSF3
24thymoma30.6IL2, IL1R1, TNFRSF4
25pancytopenia30.6THPO, IL2RA, CSF3
26myositis30.6CD28, GZMB
27systemic lupus erythematosus30.5IL2, IL2RB, IL1R1, IL18, IL10, IL15
28breast cancer30.5CENPF, THPO, KIR3DL1, IL2, IL1R1, IL15
29atopic dermatitis30.5IL2, IL2RB, IL18, IL10, IL2RA, LTA
30uveitis30.5IL1R1, IL10, IL2RA, LTA, TNF, IFNG
31hepatitis b30.5IL18, IL10, IL2RA, IFNG, CCR5
32glomerulonephritis30.5IL1R1, CD28, CCR5
33neutropenia30.5THPO, CSF3, GZMB
34sarcoma30.5THPO, IL2, IL1R1
35lupus erythematosus30.5IL18
36aspergillosis30.5IFNG
37dermatomyositis30.5CD28
38myelofibrosis30.5THPO, CSF3
39multiple sclerosis30.3THPO, IL2, IL2RB, IL1R1, IL18, IL10
40melanoma30.3KIR3DL1, IL2, IL2RB, IL10, IL15, CD28
41psoriasis30.3KIR3DL1, IL2, IL1R1, IL18, IL10, IL15
42lymphopenia30.3IL2, IL2RB, IL18, IL10, IL15, IL2RA
43encephalomyelitis30.3IL2, IL10, LTA, FASLG, TNFRSF4, TNF
44t-cell large granular lymphocyte leukemia30.3IL2, IL2RB, IL18, FASLG, GZMB
45anaplastic large cell lymphoma30.3IL2RB, IL2RA, GZMB
46obesity30.3IL18, IL15, TNF
47acute pancreatitis30.3IL1R1, IL18, IL10
48cervical cancer30.3IL1R1, IL15
49monocytic leukemia30.3IL1R1, TNF, IFNG
50thyroiditis30.3FASLG

Graphical network of the top 20 diseases related to Graft Versus Host Disease:



Diseases related to graft versus host disease

Clinical Features for Graft Versus Host Disease

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Drugs & Therapeutics for Graft Versus Host Disease

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Graft Versus Host Disease

Drug clinical trials:

Search ClinicalTrials for Graft Versus Host Disease

Search NIH Clinical Center for Graft Versus Host Disease

Search CenterWatch for Graft Versus Host Disease

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Graft Versus Host Disease cell therapies at LifeMap Discovery.

Genetic Tests for Graft Versus Host Disease

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Anatomical Context for Graft Versus Host Disease

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30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Graft Versus Host Disease:

32
T cells, Bone, Bone marrow, Skin, Liver, B cells, Endothelial, Myeloid, Eye, Lung, Colon, Monocytes, Testes, Kidney, Nk cells, Tongue, Pancreas, Breast, Thyroid, Heart, Salivary gland, Spleen, Lymph node, Whole blood, Thymus

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Graft Versus Host Disease:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Graft Versus Host Disease or affiliated genes

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36MGI
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Publications for Graft Versus Host Disease

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50PubMed
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Articles related to Graft Versus Host Disease:

(show top 50)    (show all 1669)
idTitleAuthorsYear
1
Evaluation of risk for graft-versus-host disease in children who receive less than the full doses of mini-dose methotrexate for graft-versus-host disease prophylaxis in allogeneic hematopoietic stem cell transplantation. (24348662)
2013
2
Serum albumin level predicts survival of patients with gastrointestinal acute graft-versus-host disease after allogeneic stem cell transplantation. (24248672)
2013
3
Histopathological diagnosis of graft-versus-host disease of the skin - an interobserver comparison. (23906476)
2013
4
Reduced efficacy of mesenchymal stromal cells in preventing graft-versus-host disease in an in vivo model of haploidentical bone marrow transplant with leukemia. (23044223)
2013
5
Oral chronic graft-versus-host disease: current pathogenesis, therapy, and research. (23107104)
2013
6
Extracorporeal photopheresis: a useful therapy for patients with steroid-refractory acute graft-versus-host disease but not for the prevention of the chronic form. (23534380)
2013
7
Multiparameter single-cell profiling of human CD4+FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host disease. (23818545)
2013
8
MicroRNAs: The Missing Link in the Biology of Graft-Versus-Host Disease? (24348483)
2013
9
Patient HLA-DP-specific CD4+ T cells from HLA-DPB1-mismatched donor lymphocyte infusion can induce graft-versus-leukemia reactivity in the presence or absence of graft-versus-host disease. (22871556)
2013
10
TLR4 inactivation protects from graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. (23262974)
2013
11
A critical role for the retinoic acid signaling pathway in the pathophysiology of gastrointestinal graft-versus-host disease. (23529927)
2013
12
Prevention of graft-versus-host disease. (23187772)
2012
13
Evaluation of oral beclomethasone dipropionate for prevention of acute graft-versus-host disease. (22079469)
2012
14
Isotopic response of graft versus host disease following herpes zoster infection: case report and review of the literature. (22293729)
2012
15
Response and survival of patients with chronic graft-versus-host disease treated by extracorporeal photochemotherapy: a retrospective study according to classical and National Institutes of Health classifications. (22320219)
2012
16
High frequencies of CD62La8_ naive regulatory T cells in allografts are associated with a low risk of acute graft-versus-host disease following unmanipulated allogeneic haematopoietic stem cell transplantation. (21635226)
2011
17
Clinical significance of anti-mitochondrial antibodies in a patient with chronic graft-versus-host disease following hematopoietic stem cell transplantation. (22065977)
2011
18
N-acetyl-L-cysteine increases acute graft-versus-host disease and promotes T-cell-mediated immunity in vitro. (21337541)
2011
19
Elafin is a biomarker of graft-versus-host disease of the skin. (20371463)
2010
20
Intestinal acute graft versus host disease. (20726356)
2010
21
Acute graft-versus-host disease after living donor liver transplantation with donor-dominant one-way human leukocyte antigen matching at two Loci. (20440198)
2010
22
Colonic cryptosporidiosis in allograft patients: a rare differential diagnosis of acute graft-versus-host disease. (20466123)
2010
23
Dermatomyositis-like muscle pathology in patients with chronic graft-versus-host disease. (19670319)
2009
24
Encephalomyelitis mimicking multiple sclerosis associated with chronic graft-versus-host disease after allogeneic bone marrow transplantation. (19687597)
2009
25
Phase II study of tacrolimus and methotrexate for prophylaxis of acute graft-versus-host disease after HLA-A, B, and DRB1 genotypically mismatched unrelated bone marrow transplantation among Japanese patients. (19052693)
2009
26
A case of chronic cutaneous graft versus host disease with the clinical features of exfoliative dermatitis. (20523815)
2009
27
Endpoints for clinical trials testing treatment of acute graft-versus-host disease: a joint statement. (19539208)
2009
28
Classic and overlap chronic graft-versus-host disease (cGVHD) is associated with superior outcome after extracorporeal photopheresis (ECP). (19747637)
2009
29
Minor ABO-mismatches are risk factors for acute graft-versus-host disease in hematopoietic stem cell transplant patients. (19822299)
2009
30
Role of dendritic cells and chemokines in acute graft-versus-host disease. (17981692)
2008
31
Importance of interleukin-7 in the development of experimental graft-versus-host disease. (18158957)
2008
32
Inflammatory cytokines and dendritic cells in acute graft-versus-host disease after allogeneic stem cell transplantation. (18083060)
2008
33
High levels of B-cell activating factor in patients with active chronic graft-versus-host disease. (17947475)
2007
34
Pathophysiology of acute graft-versus-host disease: recent advances. (17900507)
2007
35
Sparing effect by montelukast treatment for chronic graft versus host disease: a pilot study. (17353777)
2007
36
Induction of autologous graft-versus-host disease: results of a randomized prospective clinical trial in patients with poor risk lymphoma. (17889355)
2007
37
Association with the presence of naive T cells in chronic myeloid leukemia patients after allogeneic human stem cell transplantation and the lower incidence of chronic graft-versus host disease and relapse. (18022011)
2007
38
Suicide gene therapy of graft-versus-host disease induced by central memory human T lymphocytes. (16293601)
2006
39
The impact of acute and chronic graft-versus-host disease on normal and malignant B-lymphoid precursors after allogeneic stem cell transplantation for B-lineage acute lymphoblastic leukemia. (16531257)
2006
40
A case of severe sclerodermatous chronic graft-versus-host disease: exposure to cement containing abundant silica may have been a relevant factor in scleroderma-like skin changes. (16043910)
2005
41
Protective conditioning for acute graft-versus-host disease. (16192477)
2005
42
Chronic graft-versus-host disease after reduced-intensity stem cell transplantation versus conventional hematopoietic stem cell transplantation. (16019440)
2005
43
Prognostic value of apoptotic cells and infiltrating neutrophils in graft-versus-host disease of the gastrointestinal tract in humans: TNF and Fas expression. (12881313)
2004
44
Latency-associated peptide prevents skin fibrosis in murine sclerodermatous graft-versus-host disease, a model for human scleroderma. (14632186)
2003
45
Sperm protein 17 (Sp17) in multiple myeloma: opportunity for myeloma-specific donor T cell infusion to enhance graft-versus-myeloma effect without increasing graft-versus-host disease risk. (11477539)
2001
46
The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation. (10779417)
2000
47
Elevated interleukin (IL)-18 levels during acute graft-versus-host disease after allogeneic bone marrow transplantation. (10886219)
2000
48
The effect of hydroxychloroquine on alloreactivity and its potential use for graft-versus-host disease. (8807116)
1996
49
Use of a somatostatin analogue, octreotide acetate, in the management of acute gastrointestinal graft-versus-host disease. (2042686)
1991
50
Quantitation of the T cell deficiency in RFM mice with host versus graft disease. (157816)
1979

Genetic Variations for Graft Versus Host Disease

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Expression for genes affiliated with Graft Versus Host Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Graft Versus Host Disease

Search GEO for disease gene expression data for Graft Versus Host Disease.

Pathways for genes affiliated with Graft Versus Host Disease

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Sources:
51QIAGEN, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems, 53Reactome, 4Cell Signaling Technology
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Pathways related to Graft Versus Host Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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11.7THPO, CCR5, CSF3, TNF, TNFRSF4, LTA
2
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11.3IFNG, GZMB, TNF, FASLG, LTA, CD28
3
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11.3IFNG, TNF, FASLG, LTA, CD28, IL2RA
4
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11.2IL2, IL2RB, CCR5, IFNG, GZMB, FASLG
5
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11.2GZMB, TNF, FASLG, IL2RA, IL15, IL10
6
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11.2CSF3, TNFRSF4, LTA, CD28, IL2RA, IL15
711.2IFNG, GZMB, TNF, TNFRSF4, FASLG, IL2RA
8
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11.2CCR5, TNFRSF4, THPO, IL2RB, IL18, IL15
9
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11.1IFNG, CD28, IL2RA, IL18, IL1R1, IL2RB
10
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11.1TNF, LTA, IL2RA, IL15, IL2RB, IL2
1111.1IFNG, CSF3, IL2RA, IL15, IL10, IL2RB
12
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11.1CCR5, CSF3, TNFRSF4, FASLG, CD28, IL2RA
1311.1IL18, IL10, IL15, LTA, TNF, IFNG
14
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11.1IFNG, TNF, LTA, CD28, IL10, IL18
15
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11.0IFNG, TNF, IL2RA, IL1R1, IL2RB, IL2
16
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11.0IFNG, IL2RA, IL18, IL1R1, IL2RB, IL2
17
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11.0IFNG, GZMB, TNF, FASLG, IL2, KIR3DL1
1811.0GZMB, FASLG, IL2RA, IL10, IL2RB, IL2
19
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11.0CCR5, IFNG, TNF, CD28, IL10, IL2
20
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10.9IFNG, TNF, FASLG, IL2RA, IL2
21
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10.9GZMB, TNF, FASLG, LTA, IL1R1
2210.9IFNG, TNF, FASLG, IL10, IL18
23
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10.9IL2RA, IL18, IL1R1, IL2RB, IL2
24
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10.9FASLG, LTA, IL2RA, IL2RB, IL2
25
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10.9IL2, IL10, FASLG, TNF, IFNG
2610.9CSF3, TNF, IL2RA, IL1R1, THPO
2710.9IL2, IL2RB, IL2RA, FASLG, CSF3
2810.9IL2RA, IL15, IL1R1, IL2RB, IL2
2910.9IFNG, TNFRSF4, LTA, IL10, IL2
30
Development PDGF signaling via STATs and NF-kB
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10.9IFNG, TNF, IL10, IL18, IL2
3110.9IL2, IL2RB, IL2RA, CD28, IFNG
32
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10.9LTA, IL2RA, IL2RB, IL2, THPO
3310.9IFNG, CD28, IL2RA, IL18, IL2
34
Immune response Bacterial infections in normal airways
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10.8IFNG, TNF, FASLG, IL1R1
35
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10.8TNF, TNFRSF4, LTA, IL1R1
3610.8IFNG, TNF, IL10, IL1R1
37
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10.8IL1R1, LTA, FASLG, TNF
38
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10.8IFNG, IL2RA, IL2RB, IL2
39
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10.8TNF, LTA, IL1R1, THPO
40
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10.8LTA, FASLG, TNF, CCR5
4110.8TNF, LTA, CD28, IL1R1
42
Hide members
10.8CD28, IL2RA, IL2RB, IL2
4310.8IL2, IL2RB, IL2RA, CD28
4410.7IL2, IL1R1, TNF
4510.7IFNG, TNF, IL2
46
Hide members
10.7IL1R1, CD28, GZMB
47
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10.7CCR5, IFNG, LTA
4810.7IL18, IL15, CD28
49
Hide members
10.6IL18, CCR5
5010.6IL18

Compounds for genes affiliated with Graft Versus Host Disease

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44Novoseek, 24HMDB, 49PharmGKB, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Graft Versus Host Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 188)
idCompoundScoreTop Affiliating Genes
1tyrosine4412.1KIR3DL1, IL2, CSF3, CCR5, IL15, GZMB
2rapamycin4412.0IL2RB, IL2, THPO, IL1R1, IL18, CCR5
3ionomycin4411.9IL18, IL10, IL2RB, IL2, IL15, LTA
4thymidine44 2412.9IFNG, CSF3, TNF, FASLG, IL2RA, IL15
5rantes4411.9THPO, IL2, IFNG, GZMB, CSF3, TNF
6vegf4411.9GZMB, CSF3, TNF, FASLG, LTA, IL2RA
7tacrolimus44 49 1113.9IL2RA, IL15, IL10, IL18, IL2RB, IL2
8il 104411.9CCR5, IL2, IFNG, TNF, LTA, IL2RA
9retinoic acid44 2412.8TNF, THPO, CSF3, IL2RB, CCR5, IL1R1
10cyclosporin a44 28 5913.8GZMB, CSF3, TNFRSF4, LTA, CD28, IL2RA
11neopterin4411.7LTA, TNF, GZMB, IFNG, IL18, IL2
12infliximab44 49 1113.7IL10, IL2RA, LTA, TNF, IL15, IL1R1
13histamine44 28 2413.7THPO, CCR5, TNF, IL2RA, IL15, IL10
14nitric oxide44 11 2413.7LTA, IL15, GZMB, IL10, IL18, IL1R1
15okt34411.6IL2RB, IL2, IL10, IL15, IFNG, TNF
16methotrexate44 49 1113.6IL18, CSF3, TNF, FASLG, IL2RA, IL15
17etanercept44 49 1113.6IL2RB, IL1R1, TNF, IL18, IL10, IL15
18ccl344 2812.6TNF, CSF3, IFNG, CCR5, IL10, IL18
19rituximab44 49 1113.5IL2RA, IL1R1, CSF3, IL10, IL15, TNF
20thalidomide44 49 59 1114.5IL18, IL10, IL2RA, FASLG, TNF, IFNG
21il-124411.5IL2, IL1R1, IL18, IL10, IL15, TNF
22cyclophosphamide44 49 1113.5FASLG, IL2RA, CSF3, IL15, IL2, IL2RB
23con a4411.5IL2RA, CD28, IFNG, IL2RB, IL10, IL18
24mycophenolate mofetil44 49 1113.4IFNG, IL2RB, IL2, IL10, IL2RA, CSF3
25ifn-alpha4411.4IL2RB, IL18, IL10, IL2RA, FASLG, IL2
265fluorouracil4411.4IFNG, FASLG, CSF3, IL2RA, IL15, IL18
27chloroquine44 2 49 28 1115.4IL1R1, IL2, IL18, IL10, IL15, IL2RA
28prednisolone44 28 1113.3GZMB, LTA, IL2RA, IL1R1, IL2RB
29dexamethasone44 49 28 1114.3IL1R1, IL15, LTA, FASLG, GZMB
30polyinosinic-polycytidylic acid4411.3IL18, IL10, IL15, IL2, IFNG, TNF
31gm-csf44 2812.3IFNG, TNF, IL10, THPO
32ivig4411.3CCR5, IFNG, IL1R1, IL2RB
33pentoxifylline44 1112.2LTA, IL18, IL1R1, IL2RB
34alpha-galactosylceramide4411.2IL15, IFNG, GZMB, IL2, IL10
35tgf beta14411.2TNF, IL18, IL10, THPO, IL15, LTA
36cycloheximide4411.2IL18, LTA, FASLG, IL2RB
37ribavirin44 49 1113.2IL10, IL2, IL18, CSF3, IFNG, CCR5
38tuberculin4411.1IL15, IL10, IL18, IFNG, IL2RA
39gold sodium thiomalate4411.1IFNG, TNF, IL2RA, IL1R1, IL2
40natalizumab44 1112.1IL10, IL2RA, IFNG, TNF, IL18
412,5-oligoadenylate4411.1TNF, IL2, IL2RB, IL2RA
42actinomycin d4411.1FASLG, TNF, THPO, IL2, IL1R1, LTA
43endotoxin4411.0FASLG, CSF3
44imiquimod44 28 59 1114.0TNF, IL10, IL18, IFNG, FASLG
45pge24411.0IL2
46lipoteichoic acid4410.9IL1R1, IL10, LTA, TNF, IL18
47indomethacin44 59 28 1113.9IL1R1
48chromium4410.9KIR3DL1, IL2RB, GZMB
49interferon gamma4410.8TNF, IL2, IL10, IFNG
50ctla4-ig4410.5IL2RB, IL15, CD28, IL2

GO Terms for genes affiliated with Graft Versus Host Disease

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16Gene Ontology
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Cellular components related to Graft Versus Host Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588711.2TNF, TNFRSF4, FASLG, CD28, IL15, IL1R1
2external side of plasma membraneGO:00989711.1IL2RB, CCR5, IFNG, TNF, TNFRSF4, FASLG
3extracellular spaceGO:00561511.0IFNG, CSF3, TNF, FASLG, LTA, IL15

Biological processes related to Graft Versus Host Disease according to GeneCards/GeneDecks:

(show all 35)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.7KIR3DL1, CCR5, CSF3, TNFRSF4, FASLG, IL2RA
2cell-cell signalingGO:00726711.5CCR5, FASLG, LTA, IL15, IL10, IL18
3inflammatory responseGO:00695411.4CCR5, TNF, TNFRSF4, IL15, IL10, IL18
4apoptotic processGO:00691511.3IFNG, GZMB, TNF, FASLG, LTA, IL2RA
5cell surface receptor signaling pathwayGO:00716611.3CCR5, IFNG, CD28, IL2RA, IL1R1
6response to drugGO:04249311.3IFNG, TNF, LTA, IL10, CENPF
7positive regulation of transcription from RNA polymerase II promoterGO:04594411.2IL2, IL10, CD28, TNF, CSF3, IFNG
8negative regulation of growth of symbiont in hostGO:04413011.2IL10, LTA, TNF, IFNG
9positive regulation of interferon-gamma productionGO:03272911.2TNF, LTA, IL18, IL2
10humoral immune responseGO:00695911.2IFNG, TNF, LTA, CD28
11cellular response to lipopolysaccharideGO:07122211.2CCR5, IFNG, CSF3, IL10
12positive regulation of isotype switching to IgG isotypesGO:04830411.1IFNG, CD28, IL2
13positive regulation of tissue remodelingGO:03410511.1IL15, IL18, IL2
14positive regulation of interleukin-17 productionGO:03274011.1IL2, IL18, IL15
15positive regulation of activated T cell proliferationGO:04210411.1IL2, IL18, IL2RA
16positive regulation of neuron apoptotic processGO:04352511.0IL18, FASLG, TNF
17positive regulation of vitamin D biosynthetic processGO:06055711.0IFNG, TNF
18positive regulation of T cell proliferationGO:04210211.0IL15, CD28, IFNG
19regulation of T cell homeostatic proliferationGO:04601311.0IL2RA, IL2
20positive regulation of chronic inflammatory response to antigenic stimulusGO:00287611.0TNF, LTA
21positive regulation of inflammatory responseGO:05072911.0IL15, IL18, IL2
22positive regulation of calcidiol 1-monooxygenase activityGO:06055911.0IFNG, TNF
23activation of necroptosis by extracellular signalsGO:06055511.0TNF, FASLG
24receptor biosynthetic processGO:03280011.0TNF, IL10
25type 2 immune responseGO:04209210.9IL10, IL18
26necrotic cell deathGO:07026510.9TNF, FASLG
27negative regulation of cytokine secretion involved in immune responseGO:00274010.8TNF, IL10
28MAPK cascadeGO:00016510.8CCR5, TNF, IL18
29positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.8LTA, TNF
30positive regulation of natural killer cell proliferationGO:03281910.8IL18, IL15
31positive regulation of MHC class II biosynthetic processGO:04534810.7IL10, IFNG
32positive regulation of immunoglobulin secretionGO:05102410.6IL2, TNFRSF4
33lymph node developmentGO:04853510.6IL15, LTA
34positive regulation of chemokine biosynthetic processGO:04508010.6IFNG, TNF
35positive regulation of apoptotic processGO:04306510.5IL2RA, LTA, FASLG, TNF

Molecular functions related to Graft Versus Host Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512511.4THPO, IFNG, CSF3, TNF, FASLG, LTA
2tumor necrosis factor receptor bindingGO:00516410.8TNF, FASLG, LTA
3protease bindingGO:00202010.7IL1R1, CD28, TNF
4interleukin-2 receptor activityGO:00491110.7IL2RB, IL2RA
5interleukin-2 bindingGO:01997610.6IL2RB, IL2RA
6growth factor activityGO:00808310.5CSF3, IL10, IL2, THPO

Products for genes affiliated with Graft Versus Host Disease

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Sources for Graft Versus Host Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet