Graft Versus Host Disease malady

Wikipedia: Graft-versus-host disease (GVHD) is a common complication following an allogeneic tissue transplant. It...⁴⁴ more...

MalaCards: Graft Versus Host Disease, also known as graft-vs-host disease, is related to acute graft versus host disease and hepatitis. An important gene associated with Graft Versus Host Disease is CENPF (centromere protein F, 350/400kDa (mitosin)), and among its related pathways are RAR-Gamma-RXR-Alpha Degradation and Antigen processing and presentation. The drugs prednisone pwdr [va product] and muromonab-cd3 and the compounds glucose and peptidoglycan have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, small intestine and colon, and related mouse phenotypes are hematopoietic system and endocrine/exocrine gland.

graft versus host disease 32 graft-vs-host disease 43

Diseases related to graft versus host disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 963)

id	Related Disease	Score	Top Affiliating Genes
1	acute graft versus host disease	44.2	KIR3DL1, GZMB, IL10, IL15, IL18, IL1R1
2	hepatitis	33.3	GZMB, IL2RB, FASLG, FAS, IFNA1, F2
3	gamma chain deficiency	33.2	IL13, IL15, IL18R1, IL2, IL2RA, IL2RB
4	immunodeficiency	32.9	PDCD1, KIR3DL1, SELL, BMP6, PARP1, PADI4
5	chronic myeloid leukemia	32.6	KIR3DL1, BMI1, GZMB, IL11, IL1RAPL2, IL3
6	toxic epidermal necrolysis	32.3	MMP9, GZMB, IL2, FASLG, FAS, CCL5
7	sepsis	32.3	CD14, IL10, TNF, LTA
8	chronic lymphocytic leukemia	32.3	SELL, CD28, CD86, CD4, CD40LG, CD80
9	oral lichen planus	31.7	VCAM1, IL1A, CCR5, CCL5, ICAM1, HSPA4
10	catastrophic antiphospholipid syndrome	31.6	MTHFR, CD40LG, APOH, F5, F3, HLA-DRB4
11	lipodystrophy	31.5	CD4, IL18, IL18BP, IL6, FAS, HLA-A
12	glucocorticoid resistance	31.1	CD28, MIF, IL10, IL1A, IL1B, IL1R1
13	polymyositis	30.1	PIK3C2A, VEGFA, VCAM1, CD28, CD86, CD80
14	breast cancer	29.4	VEGFA, VDR, MTHFR, XRCC1, MMP9, GSTM1
15	myositis	29.3	PIK3C2A, VCAM1, CIITA, CD28, CD36, CD86
16	thrombocytopenia	29.2	PIK3C2A, SELL, BMP6, MTHFR, CD79A, CD36
17	lichen planus	29.2	PCNA, VEGFA, VCAM1, CD79A, CD14, CD4
18	antiphospholipid syndrome	28.7	VEGFA, VCAM1, MTHFR, CD79A, CD40LG, MMP9
19	acute leukemia	28.5	SELL, VEGFA, BMI1, BMP6, LIG1, PADI4
20	lupus nephritis	28.4	PDCD1, PCNA, VEGFA, VCAM1, BMP6, CIITA
21	leukemia	28.0	PIK3C2A, RFC1, PDCD1, KIR2DS3, KIR2DS5, KIR3DL2
22	myeloid leukemia	26.8	PIK3C2A, PDCD1, KIR2DS3, KIR2DS5, KIR3DL2, KIR2DL1
23	iron overload	26.7	VDR, BMP6, GSTM1, IFNA1, F5, F2
24	psoriasis	26.6	PI3, RFC1, KIR2DS3, KIR2DS5, KIR3DL2, KIR2DL1
25	dermatitis	26.4	PIK3C2A, PI3, KIR3DL2, SELL, VEGFA, VCAM1
26	nephritis	26.2	PDCD1, PCNA, VEGFA, VCAM1, BMP6, PARP1
27	lymphocytic leukemia	25.0	KIR2DL1, KIR2DL3, KIR3DL1, SELL, VEGFA, VCAM1
28	multiple myeloma	24.5	PCNA, VEGFA, VCAM1, BMI1, BMP6, PARP1
29	acute myeloid leukemia	24.3	PIK3C2A, KIR2DL3, SELL, VEGFA, VDR, BMI1
30	blindness	23.9	PIK3C2A, VEGFA, VDR, MTHFR, CD79A, CD36
31	obesity	23.1	PIK3C2A, KIR2DL1, KIR2DL3, KIR3DL1, PCNA, SELL
32	myeloma	22.6	PCNA, SELL, VEGFA, VDR, VCAM1, BMI1
33	fibrosis	21.9	PI3, PCNA, SELL, VEGFA, VDR, VCAM1
34	hodgkin's lymphoma	14.8	BMI1, CD28, CD80, CD40, GZMB, IL13
35	lymphopenia	14.8	SELL, CIITA, CD28, CD4, FOXP3, IL10
36	large granular lymphocyte leukemia	14.8	KIR2DL1, KIR2DL3, IL10, IL15, IL18, IL2
37	pulmonary sarcoidosis	14.8	SELL, CD80, ITGAL, IL18, IL2, IL2RA
38	diffuse infiltrative lymphocytosis syndrome	14.7	SELL, CD28, GZMB, IL2, IL2RA, IL2RB
39	vogt-koyanagi-harada disease	14.7	KIR2DS3, KIR2DS5, KIR3DL2, KIR2DL1, KIR2DL3, KIR3DL1
40	crohn's disease	14.6	CD80, FOXP3, IRF1, MIF, FGF10, FGF7
41	cutaneous t cell lymphoma	14.6	SELL, ITGAL, GZMB, IL15, IL2, IL2RA
42	adult t-cell leukemia	14.5	KIR2DL1, KIR2DL3, CIITA, CD4, CD40, ITGAL
43	cytomegalovirus retinitis	14.5	IL10RA, IL2, FASLG, CCR5, IFNG, IDO1
44	t-cell large granular lymphocyte leukemia	14.5	GZMB, IL18, IL2, IL2RB, FASLG, TRB@
45	periapical granuloma	14.5	IL1A, IL2, IL2RA, IL4, CCR5, CCL3
46	panniculitis	14.5	GZMB, IL2RA, IL2RB, APOH, FAS, IFNG
47	chronic mucocutaneous candidiasis	14.5	CD79A, CD86, IL10, IL17A, IL17F, IL2
48	bronchogenic carcinoma	14.5	IL10, IL1RN, IL2, IL2RB, IL3, TNF
49	aplastic anemia	14.4	GZMB, GSTM1, GSTT1, IL11, IL3, FASLG
50	dyserythropoietic anemia with thrombocytopenia	14.4	GZMB, IL11, IL3, IL7, FAS, IFNA1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 muromonab-cd3, prednisone, prednisone pwdr [va product]

Cell-based therapeutics:

MalaCards organs/tissues related to graft versus host disease:

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MGI Mouse Phenotypes related to graft versus host disease:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	11.1	RFX5, PDCD1, PCNA, BMI1, LIG1, UNG
2	endocrine/exocrine gland phenotype	MP:0005379	11.0	SELL, CD40LG, FGF10, IL2, IL22, IL2RB
3	respiratory system phenotype	MP:0005388	10.9	SELL, CLEC7A, CD14, FKBP1A, FEN1, IL10RB
4	renal/urinary system phenotype	MP:0005367	9.7	PDCD1, FGF10, F2RL1, ESR1, ESR2, TNFRSF1B
5	immune system phenotype	MP:0005387	9.7	RFX5, SELL, VDR, BMI1, LIG1, PADI4
6	reproductive system phenotype	MP:0005389	9.1	VEGFA, VDR, MMP9, FOXP3, FGF10, IL10
7	liver/biliary system phenotype	MP:0005370	9.0	RFX5, VEGFA, LIG1, CD36, FKBP1A, FEN1
8	integument phenotype	MP:0010771	8.9	LIG1, PARP1, CD4, FOXP3, IRF1, FKBP1A
9	no phenotypic analysis	MP:0003012	8.8	PCNA, VEGFA, VCAM1, PARP1, LGALS9, MTHFR
10	vision/eye phenotype	MP:0005391	8.8	PDCD1, VEGFA, BMI1, MTHFR, CD36, MMP9
11	embryogenesis phenotype	MP:0005380	8.7	BMI1, LIG3, LIG1, PARP1, XRCC1, ITGB7
12	skeleton phenotype	MP:0005390	8.6	VEGFA, VDR, BMI1, BMP6, LGALS9, MTHFR
13	digestive/alimentary phenotype	MP:0005381	8.6	VEGFA, VDR, BMI1, CLEC7A, MUC5AC, CD36
14	muscle phenotype	MP:0005369	8.4	PDCD1, VEGFA, LIG3, CD36, CD86, MMP9
15	growth/size phenotype	MP:0005378	8.4	PIK3C2A, VDR, VCAM1, BMI1, BMP6, LIG3
16	normal phenotype	MP:0002873	8.3	VEGFA, BMI1, PADI4, UNG, CIITA, XRCC1
17	tumorigenesis	MP:0002006	8.1	SELL, BMI1, LIG1, UNG, MUTYH, XRCC1
18	nervous system phenotype	MP:0003631	8.1	PDCD1, BMI1, LIG3, PARP1, UNG, MTHFR
19	behavior/neurological phenotype	MP:0005386	7.8	BMI1, LIG3, XRCC1, CD86, FOXP3, GSTM1
20	mortality/aging	MP:0010768	7.6	PIK3C2A, PDCD1, VEGFA, VDR, VCAM1, BMI1
21	cellular phenotype	MP:0005384	7.2	PDCD1, PCNA, SELL, VEGFA, VDR, VCAM1
22	cardiovascular system phenotype	MP:0005385	7.0	RFX5, PDCD1, SELL, VEGFA, VDR, VCAM1
23	homeostasis/metabolism phenotype	MP:0005376	4.9	PIK3C2A, SELL, VEGFA, VDR, VCAM1, LIG3

Articles related to graft versus host disease:

(show top 50)    (show all 339)

id	Title	Authors	Year	Affiliating Genes
1	High levels of B cell activating factor during the pe ritransplantation period are associated with a reduced incidence of acute graft -versus-host disease following myeloablative allogeneic stem cell transplantati on. (19963070)	Cho B.S.... Chung N.G.	2010	TNFSF13B
2	Polymorphisms in the base excision repair pathway and graft-versus-host disease. (20574454)	Arora M.... Thyagarajan B.	2010	LIG1, PARP1, FEN1
3	Donor-recipient mismatch for common gene deletion pol ymorphisms in graft-versus-host disease. (19935662)	McCarroll S.A.... Altshuler D.	2009	UGT2B17
4	In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations. (18957685)	Carlson M.J.... Serody J.S.	2009	IL17A, IL22, IL17F
5	Limited role of MHC class I chain-related gene A (MIC A) typing in assessing graft-versus-host disease risk after fully human leukocy te antigen-matched unrelated donor transplantation. (19965715)	Anderson E.... Verneris M.R.	2009	HLA-B
6	Vascular endothelial growth factor gene polymorphisms may predict the risk of acute graft-versus-host disease following allogeneic transplantation: preventive effect of vascular endothelial growth factor gene on acute graft-versus-host disease. (19041064)	Kim D.H.... Sohn S.K.	2008	VEGFA
7	Establishment of an xenogeneic acute graft-versus-host disease model in NOD/SCID mice by engraftment of G-CSF mobilized human mononuclear cells (18681307)	Gao L.... Qiu H.Y.	2008	CSF3
8	IL2 and TNFA gene polymorphisms and the risk of graft-versus-host disease after allogeneic haematopoietic stem cell transplantation. (18021367)	Viel D.O.... Visentainer J.E.	2007	TNF, IL2
9	CXCL10-CXCR3 interactions play an important role in the pathogenesis of acute graft-versus-host disease in the skin following allogeneic stem-cell transplantation. (17766680)	Piper K.P.... Moss P.A.	2007	CXCL10
10	Recombinant human soluble tumor necrosis factor receptor fusion protein as treatment for steroid refractory graft-versus-host disease following allogeneic hematopoietic stem cell transplantation. (16937391)	Busca A.... Falda M.	2007	TNF
11	Correlation between serum levels of IL-18 and acute graft versus host disease in patients after allogeneic hematopoietic stem cell transplantation (17605864)	Liu J.... Lu D.P.	2007	IL18
12	Exposure-effect population model of inolimomab, a monoclonal antibody administered in first-line treatment for acute graft-versus-host disease. (17465640)	Dartois C.... Girard P.	2007	IL2RA
13	Mutations in innate immune system NOD2/CARD 15 and TLR-4 (Thr399Ile) genes influence the risk for severe acute graft-versus-host disease in patients who underwent an allogeneic transplantation. (16436969)	Elmaagacli A.H.... Beelen D.W.	2006	TLR4, NOD2
14	Changes of IL-2, IL-8, IL-10 and TNF-alpha levels in sera of patients with acute graft-versus-host disease (16928315)	Wang S.H.... Yan G.T.	2006	TNF, IL2, IL10
15	Prevention of chronic graft-versus-host disease by stimulation with glucocorticoid-induced TNF receptor. (16520557)	Kim J.... Kwon B.	2006	TNFRSF18
16	Regulation of OX40 gene expression in graft-versus-host disease. (15808546)	Miura Y.... Hess A.D.	2005	TNFRSF4
17	IL-6 and IL-10 promoter gene polymorphisms of patients and donors of allogeneic sibling hematopoietic stem cell transplants associate with the risk of acute graft-versus-host disease. (15993715)	Karabon L.... Lange A.	2005	IL6, IL10
18	Donor CD31 genotype and its association with acute graft-versus-host disease in HLA identical sibling stem cell transplantation. (15908974)	Goodman R.S.... Taylor C.J.	2005	PECAM1
19	The association of CD25 expression on donor CD8+ and CD4+ T cells with graft-versus-host disease after donor lymphocyte infusions. (16219576)	Mutis T.... Verdonck L.F.	2005	IL2RA
20	Cytolytic effector mechanisms and gene expression in autologous graft-versus-host disease: distinct roles of perforin and Fas ligand. (14993881)	Miura Y.... Hess A.D.	2004	TNF, FAS, GZMB
21	Paradoxical effects of interleukin-18 on the severity of acute graft-versus-host disease mediated by CD4+ and CD8+ T-cell subsets after experimental allogeneic bone marrow transplantation. (15280194)	Min C.K.... Reddy P.	2004	IL18
22	Increased immune transcript levels are correlated with acute graft-versus-host disease and cytomegalovirus response after allogeneic stem cell transplantation. (14742980)	Jaksch M.... Mattsson J.	2004	GZMB, FASLG
23	Elevated serum interleukin-15 level in acute graft-versus-host disease after hematopoietic cell transplantation. (14663280)	Chik K.W.... Yuen P.M.	2003	IFNG, IL10, IL15
24	Repifermin (keratinocyte growth factor-2) reduces the severity of graft-versus-host disease while preserving a graft-versus-leukemia effect. (14506661)	Clouthier S.G.... Ferrara J.L.	2003	FGF10
25	Indoleamine 2,3-dioxygenase expression in patients with acute graft-versus-host disease after allogeneic stem cell transplantation and in pregnant women: association with the induction of allogeneic immune tolerance? (12588666)	Steckel N.K.... Elmaagacli A.H.	2003	IDO1
26	Cytokine and chemokine profiles in autologous graft-versus-host disease (GVHD): interleukin 10 and interferon gamma may be critical mediators for the development of autologous GVHD. (12239181)	Miura Y.... Hess A.D.	2002	IL4, IFNG, IL10
27	Macrophage migratory inhibitory factor (MIF) expression in acute graft-versus-host disease (GVHD) in allogeneic hemopoietic stem cell transplant recipients. (12235522)	Lo J.W.... Lan H.Y.	2002	MIF
28	An association between human leucocyte antigen alleles and acute and chronic graft-versus-host disease after allogeneic haematopoietic stem cell transplantation. (12437654)	Remberger M.... Ringden O.	2002	HLA-A, HLA-B
29	Similarity between eruptions induced by sulfhydryl drugs and acute cutaneous graft-versus-host disease after bone marrow transplantation. (12171778)	Takatsuka H.... Kakishita E.	2002	IL2RA, IL2
30	Comparison of the distribution and numbers of antigen-presenting cells among T-lymphocyte-mediated dermatoses: CD1a+, factor XIIIa+, and CD68+ cells in eczematous dermatitis, psoriasis, lichen planus and graft-versus-host disease. (12373334)	Deguchi M.... Tagami H.	2002	F13A1
31	New therapeutic modalities in the treatment of graft- versus-host disease. (11311659)	Basara N.... Fauser A.A.	2001	IL2RB
32	Donor-recipient incompatibility at CD31-codon 563 is a major risk factor for acute graft-versus-host disease after allogeneic bone marrow transplantation from a human leucocyte antigen-matched donor. (11564091)	Balduini C.L.... Locatelli F.	2001	MYH9
33	Major histocompatibility complex-mismatched allogeneic bone marrow transplantation using perforin and/or Fas ligand double-defective CD4(+) donor T cells: involvement of cytotoxic function by donor lymphocytes prior to graft-versus-host disease pathogenesis. (11435308)	Jiang Z.... Levy R.B.	2001	FAS, FASLG
34	Cytokine gene polymorphism in patients with graft-versus-host disease. (11266928)	Tambur A.R.... Klein T.	2001	TGFB1, TNF, IL6
35	Serum levels of soluble IL-2 receptor, IL-12, IL-18, and IFN-gamma in patients with acute graft-versus-host disease after allogeneic bone marrow transplantation. (10887333)	Nakamura H.... Masaoka T.	2000	IL18, IFNG, IL2RB
36	Tacrolimus does not abrogate the increased risk of ac ute graft-versus-host disease after unrelated-donor marrow transplantation with allelic mismatching at HLA-DRB1 and HLA-DQB1. (10816027)	Przepiorka D.... Champlin R.	2000	HLA-B
37	Contribution of TNF-alpha and IL-10 gene polymorphisms to graft-versus-host disease following allo-hematopoietic stem cell transplantation. (11223972)	Takahashi H.... Koike T.	2000	TNF, IL10
38	Soluble interleukin-2 receptor concentration as a biochemical indicator for acute graft-versus-host disease after allogeneic bone marrow transplantation. (10894361)	Mathias C.... Porter D.L.	2000	IL2RA
39	Two cases of chronic graft-versus-host disease with elevated levels of soluble Fas ligand in serum. (10814995)	Takada S.... Miyawaki S.	2000	FASLG
40	Minimal residual disease is common after allogeneic stem cell transplantation in patients with B cell chronic lymphocytic leukemia and may be controlled by graft-versus-host disease. (10673741)	Mattsson J.... Zetterquist H.	2000	IL2RA
41	Predicting the severity of graft-versus-host disease from interleukin-10 levels after bone marrow transplantation. (10556960)	Takatsuka H.... Kakishita E.	1999	IL10
42	Prevention of graft-versus-host disease (GVHD) by elimination of recipient-reactive donor T cells with recombinant toxins that target the interleukin 2 (IL-2) receptor. (10197798)	Harris D.T.... Pastan I.	1999	IL2, IL2RB
43	Expression of T cell activation antigen CD134 (OX40) has no predictive value for the occurrence or response to therapy of acute graft-versus-host disease in partial T cell-depleted bone marrow transplantation. (10373067)	Gadisseur A.P.... Cornelissen J.J.	1999	TNFRSF4
44	Cytokine gene polymorphisms associating with severe acute graft-versus-host disease in HLA-identical sibling transplants. (9808588)	Middleton P.G.... Dickinson A.M.	1998	TNF, IL10
45	Anti-mitosin antibodies in a patient with chronic graft-versus-host disease after allogeneic bone marrow transplantation. (9156273)	Muro Y.... Hagiwara M.	1997	CENPF
46	Correlation of low histidine rich glycoprotein plasma levels with the occurrence of acute graft-versus-host disease after allogeneic bone marrow transplantation. (7636387)	Mauz-Korholz C.... Burdach S.	1995	HRG
47	The effect of human IL-2-activated natural killer and T cells on graft-versus-host disease and graft-versus-leukemia in SCID mice bearing human leukemic cells. (7482742)	Xun C.Q.... Brown S.A.	1995	IL2
48	Cytokine receptor gene expression in peripheral blood mononuclear cells during graft-versus-host disease after allogeneic bone marrow transplantation. (8535220)	Tanaka J.... Asaka M.	1995	IL2RA, IL1R1
49	Cytokine dysregulation and acute graft-versus-host disease. (1467511)	Antin J.H.... Ferrara J.L.	1992	IL1R1, IL4, IL10
50	Use of a somatostatin analogue, octreotide acetate, i n the management of acute gastrointestinal graft-versus-host disease. (2042686)	Ely P.... Weisdorf D.	1991	SST

Genes related to graft versus host disease according to GeneCards:

(show top 50)    (show all 243)

id	Symbol	Description	Score	GeneCards Section Context
1	CENPF	centromere protein F, 350/400kDa (mitosin)	11.1	Publications, Summaries
2	IL10	interleukin 10	11.1	UniProt Related, Publications
3	CSF3	colony stimulating factor 3 (granulocyte)	11.1	Publications
4	HMHA1	histocompatibility (minor) HA-1	11.0	Publications, Functions
5	TNFRSF4	tumor necrosis factor receptor superfamily, member 4	11.0	Publications
6	GZMB	granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)	11.0	Publications, Pathways & Interactions
7	KIR3DL1	killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1	11.0	Publications, Pathways & Interactions
8	IL2RB	interleukin 2 receptor, beta	11.0	Publications
9	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
10	IL1R1	interleukin 1 receptor, type I	11.0	Publications
11	IL15	interleukin 15	11.0	Publications
12	IL2	interleukin 2	11.0	Pathways & Interactions, Publications
13	FASLG	Fas ligand (TNF superfamily, member 6)	11.0	Publications, Pathways & Interactions
14	TNF	tumor necrosis factor	11.0	Publications, Pathways & Interactions
15	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
16	LTA	lymphotoxin alpha (TNF superfamily, member 1)	11.0	Publications
17	CD28	CD28 molecule	11.0	Pathways & Interactions
18	MYH9	myosin, heavy chain 9, non-muscle	11.0	Publications
19	IL4	interleukin 4	11.0	Publications
20	IFNG	interferon, gamma	11.0	Pathways & Interactions, Publications
21	SPA17	sperm autoantigenic protein 17	11.0	Publications
22	DDX3Y	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked	11.0	Publications
23	TNFRSF18	tumor necrosis factor receptor superfamily, member 18	11.0	Publications
24	KRT15	keratin 15	11.0	Publications
25	UGT2B17	UDP glucuronosyltransferase 2 family, polypeptide B17	11.0	Publications
26	HLA-DPB1	major histocompatibility complex, class II, DP beta 1	11.0	Publications, Pathways & Interactions
27	TNFRSF9	tumor necrosis factor receptor superfamily, member 9	11.0	Publications
28	PECAM1	platelet/endothelial cell adhesion molecule 1	11.0	Publications
29	FGF7	fibroblast growth factor 7	11.0	Publications
30	THPO	thrombopoietin	11.0	Publications
31	TNFRSF1A	tumor necrosis factor receptor superfamily, member 1A	11.0	Publications
32	NOD2	nucleotide-binding oligomerization domain containing 2	11.0	Publications
33	IL7	interleukin 7	11.0	Publications
34	IL11	interleukin 11	11.0	Publications
35	SELL	selectin L	11.0	Publications
36	HLA-DRB1	major histocompatibility complex, class II, DR beta 1	11.0	Pathways & Interactions, Publications
37	HLA-A	major histocompatibility complex, class I, A	11.0	Pathways & Interactions, Publications
38	IL13	interleukin 13	11.0	Publications
39	TRB@	T cell receptor beta locus	11.0	Publications
40	IL3	interleukin 3 (colony-stimulating factor, multiple)	11.0	Publications
41	CTLA4	cytotoxic T-lymphocyte-associated protein 4	11.0	Publications
42	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
43	CCR5	chemokine (C-C motif) receptor 5 (gene/pseudogene)	11.0	Publications
44	FAS	Fas (TNF receptor superfamily, member 6)	11.0	Publications, Pathways & Interactions
45	CCL5	chemokine (C-C motif) ligand 5	11.0	Publications
46	ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	11.0	Publications
47	IL1RAPL2	interleukin 1 receptor accessory protein-like 2	11.0	Publications
48	D6S207E	minor histocompatibility antigen HA-2	11.0	Publications
49	HMHB1	histocompatibility (minor) HB-1	11.0	Functions
50	KDM5D	lysine (K)-specific demethylase 5D	11.0	Publications

Pathways related to graft versus host disease according to GeneDecks:

(show top 50)    (show all 184)

id	Pathway	Score	Top Affiliating Genes
1	RAR-Gamma-RXR-Alpha Degradation36	11.5	CD80, IL11, IL15, IL16, IL2, IL22
2	Antigen processing and presentation20	11.5	RFX5, RFXANK, RFXAP, KIR2DS3, KIR2DS5, KIR3DL2
3	TNF Superfamily Pathway36	11.4	TNF, TNFRSF13C, TNFRSF18, TNFRSF1A, TNFRSF1B, TNFRSF4
4	Akt Signaling36	11.4	CD28, CD4, CD80, ITGAL, FGF10, FGF7
5	Immune response_NFAT in immune response41	11.3	CD28, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1
6	STAT3 Pathway36	11.2	BMP6, CD28, CD4, CD80, IL10, IL10RA
7	Immune response ICOS pathway in T-helper cell10	11.2	CD28, CD86, CD80, ICOS, HLA-DMA, HLA-DMB
8	Immune response_ICOS pathway in T-helper cell41	11.2	HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1
9	Toxoplasmosis20	11.1	CIITA, CD40LG, CD40, IL10, IL10RA, IL10RB
10	Immune response NFAT in immune response10	11.1	CD28, CD79A, CD86, CD80, HLA-DMA, HLA-DMB
11	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	11.0	GZMB, IL15, IL2, IL2RA, IL2RB, FASLG
12	CTLA4 Signaling36	11.0	CD28, CD86, CD4, CD80, HLA-DMA, HLA-DMB
13	Intestinal immune network for IgA production20	11.0	CD28, CD86, CD40LG, CD80, CD40, ITGB7
14	CTL Mediated Apoptosis36	11.0	GZMB, HLA-A, HLA-B, HLA-C, HLA-DMA, HLA-DMB
15	Th1 Differentiation37	11.0	CD28, CD86, CD4, CD80, IL10, IL18
16	Allograft rejection20	11.0	CD28, CD86, CD40LG, CD80, CD40, GZMB
17	PGC1Alpha Pathway36	10.9	BMP6, CD4, CD80, IL10RA, IL10RB, IL11
18	Staphylococcus aureus infection20	10.9	ITGAL, FCGR2A, IL10, ICAM1, HLA-DMA, HLA-DMB
19	CDC42 Pathway36	10.9	ITGAL, ITGB7, HLA-A, HLA-B, HLA-C, HLA-DMA
20	Phagosome20	10.9	CLEC7A, CD36, CD14, FCGR2A, HLA-A, HLA-B
21	Rho Family GTPases36	10.9	BMP6, CD80, ITGAL, ITGB7, FGF10, FGF7
22	Viral myocarditis20	10.9	CD28, CD86, CD40LG, CD80, CD40, ITGAL
23	Immune System38	10.8	PDCD1, KIR2DS5, KIR3DL2, KIR2DL1, KIR2DL3, KIR3DL1
24	Resolution of AP sites via the single-nucleotide replacement pathway38	10.8	LIG3, MUTYH, XRCC1, MPG, APEX1, MBD4
25	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.8	FOXP3, IL10, IL2, IL2RA, IL2RB, FASLG
26	Immune response Antigen presentation by MHC class II10	10.8	CD4, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1
27	Immune response_Antigen presentation by MHC class II41	10.8	CD4, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1
28	NFAT Signaling and Lymphocyte Interactions36	10.8	BMP6, CD4, CD80, IL11, IL13, IL15
29	IL-6 Pathway36	10.7	BMP6, CD80, IL10, IL11, IL16, IL18
30	all-trans-Retinoic Acid Signaling in Brain36	10.7	BMP6, CD80, IL10, IL11, IL13, IL15
31	PEDF Induced Signaling36	10.7	BMP6, CD80, IL10, IL11, IL13, IL15
32	Endothelin-1 Signaling Pathway36	10.6	BMP6, CD80, IL10, IL11, IL13, IL16
33	Antioxidant Action of Vitamin-C36	10.6	MYO1G, BMP6, CD28, CD4, CD80, FGF10
34	G-protein signaling_N-RAS regulation pathway41	10.5	CD4, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1
35	Influenza A20	10.5	CIITA, IL18, IL1A, IL1B, IL6, FASLG
36	Base excision repair20	10.5	PCNA, LIG3, LIG1, PARP1, UNG, MUTYH
37	Cytokine Network36	10.3	IL10, IL13, IL15, IL16, IL18, IL1A
38	Rheumatoid arthritis20	10.2	VEGFA, CD28, CD86, CD80, ITGAL, IL11
39	Tec Kinases Signaling36	10.2	BMP6, CD28, CD4, CD80, ITGAL, ITGB7
40	MAPK Family Pathway36	10.1	BMP6, CD4, CD80, FGF10, FGF7, IL10
41	Th17 Differentiation37	10.1	CD28, CD86, CD4, CD80, IL17A, IL17F
42	SOCS Pathway36	10.0	BMP6, CD4, CD80, FGF10, FGF7, IL10
43	TGF-Beta Pathway36	10.0	BMP6, CD4, CD80, FGF10, FGF7, IL10
44	NF-KappaB Family Pathway36	9.8	BMP6, FGF10, FGF7, IL1A, IL1B, IL1R1
45	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.7	GZMB, IL17A, IL17F, IL1B, IL22, IL23A
46	NF-KappaB (p50-p65) Pathway36	9.6	BMP6, FGF10, FGF7, IL1A, IL1B, IL1R1
47	NFAT in Immune Response36	9.6	BMP6, CD28, CD79A, CD86, CD4, CD80
48	ERK Signaling36	9.4	BMP6, CD80, ITGAL, ITGB7, FGF10, FGF7
49	Cytokine-cytokine receptor interaction20	9.3	VEGFA, CD40LG, CD40, IL10, IL10RA, IL10RB
50	JAK-STAT Pathway36	8.6	BMP6, CD4, CD80, FGF10, FGF7, IL10

Compounds related to graft versus host disease according to GeneDecks:

(show top 50)    (show all 403)

id	Compound	Score	Top Affiliating Genes
1	glucose32	11.0	CLEC7A, GZMB, MIF, IL11, IL18R1, APEX1
2	peptidoglycan32	10.9	CIITA, CD14, IL10, IL15, IL1B, IL1R1
3	indoleamine32	10.7	BMP6, IRF1, IL10, IL13, IL18, IFNA1
4	ivig32	10.6	PIK3C2A, IL18R1, IL1RAPL2, IL3, FASLG, CCR5
5	pentoxifylline32 9 9	12.6	SELL, VCAM1, BMP6, CD14, IL10, IL13
6	allergens32	10.6	PDCD1, CIITA, CD79A, CD86, CD14, CD40LG
7	leflunomide32 9 9	12.5	PCNA, IL13, IL15, IL18R1, IL1R1, IL1RN
8	tarc32	10.4	CD4, IL10, IL13, IL18, IL1A, IL4
9	groalpha32	10.3	VCAM1, IL10, IL13, IL17A, IL18, IL1A
10	h2o232	10.3	SELL, UNG, MUTYH, CD79A, CD40, ITGAL
11	glatiramer acetate32 9 9	12.3	CIITA, IL10, IL13, IL2, IL4, IL5
12	adenine32 9 18 9	13.2	UNG, MUTYH, MTHFR, MPG, IRF1, APEX1
13	calcium32 9 18 9	13.2	PIK3C2A, PI3, LGALS9, CIITA, MUC5AC, LCN1
14	lipoteichoic acid32	10.1	CD14, IL10, IL18, IL1B, IL1R1, IL1RN
15	methylcellulose32	10.1	CD14, IL11, IL15, IL1A, IL3, IL4
16	infliximab32 9 9	12.1	VEGFA, IL10, IL11, IL15, IL17A, IL18
17	2,5-oligoadenylate32	10.1	IRF1, IL10, IL2, IL2RA, IL2RB, IL6
18	dmso32	10.0	BMP6, MUC5AC, CD36, F3, HSPA4, TNFRSF1A
19	azathioprine32 34 9 9	12.9	PCNA, MTHFR, CD79A, ITGAL, GZMB, GSTP1
20	superoxide32 18	10.9	PIK3C2A, PI3, SELL, VCAM1, UNG, CD14
21	polysulfone32	9.8	SELL, VCAM1, CD14, IL1B, IL1R1, IL1RAPL2
22	manganese superoxide32	9.7	VCAM1, XRCC1, MPG, CD14, CD40, GSTM1
23	bromodeoxyuridine32	9.6	PCNA, BMP6, CIITA, FGF10, FGF7, IL13
24	zidovudine32 9 9	11.5	CD4, IL10, IL2, IL3, CCR5, CCL3
25	cytarabine32 34 9 9	12.5	PCNA, LIG1, CD36, CD80, GZMB, IL11
26	heparin32 9 18 9	12.4	PIK3C2A, CD79A, CD36, CD4, ITGAL, FGF10
27	polysaccharide32	9.3	SELL, VCAM1, BMP6, CD79A, CD14, CD4
28	etoposide32 42 9 9	12.2	PCNA, LIG1, PARP1, XRCC1, ITGAL, GZMB
29	atp32	9.2	PIK3C2A, RFC1, RFC2, RFC4, KIR3DL1, LIG1
30	n acetylcysteine32	9.2	PCNA, VCAM1, MUC5AC, CD79A, CD40, MMP9
31	imatinib32 34 9 9	12.1	SELL, VEGFA, BMP6, PARP1, GZMB, FGF7
32	epinephrine32 9 18 9	12.1	PIK3C2A, SELL, BMP6, CD79A, MMP9, FCGR2A
33	pdtc32	9.1	VCAM1, PARP1, CD40, MMP9, IRF1, IL18
34	lipid32	9.1	PIK3C2A, PI3, KIR2DL1, KIR3DL1, VCAM1, CIITA
35	thymidine32 18	10.0	PCNA, VDR, BMP6, UNG, CIITA, MTHFR
36	atorvastatin32 34 9 18 9	12.9	PIK3C2A, SELL, VEGFA, VCAM1, BMP6, CD40LG
37	butyrate32	8.9	PCNA, VDR, BMP6, CD86, CD14, CD40
38	herbimycin a32 42	9.7	SELL, VCAM1, BMP6, CD28, CD36, CD14
39	fibrinogen32	8.7	PIK3C2A, VCAM1, PADI4, CD79A, CD14, CD40LG
40	glutamate32	8.6	PCNA, VDR, BMP6, MTHFR, CD79A, CD4
41	simvastatin32 34 42 9 18 9	13.5	PIK3C2A, SELL, VEGFA, VCAM1, BMP6, CIITA
42	vitamin d32	8.3	VDR, BMP6, MTHFR, CD79A, CD36, CD14
43	cholesterol32 9 18 9	11.3	PIK3C2A, VCAM1, CIITA, MUC5AC, LCN1, MTHFR
44	curcumin32	8.2	VEGFA, VCAM1, PARP1, MMP9, MIF, GSTP1
45	estrogen32	7.2	PCNA, VDR, BMI1, UGT2B17, MUC5AC, MTHFR
46	alanine32	7.1	PIK3C2A, RFC1, PCNA, SELL, VDR, VCAM1
47	folate32	7.1	VDR, VCAM1, UNG, MTHFR, XRCC1, CD79A
48	glutamine32	7.0	PCNA, VDR, BMP6, XRCC1, CD36, CD14
49	retinoic acid32 42 18	8.4	PI3, PCNA, SELL, VDR, VCAM1, BMP6
50	methotrexate32 34 42 9 9	10.2	PIK3C2A, PCNA, BMP6, MUC5AC, MTHFR, CD79A

Cellular components related to graft versus host disease according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	integral to plasma membrane	GO:005887	11.0	KIR2DS3, KIR2DS5, KIR3DL2, KIR2DL1, KIR2DL3, CCR5
2	MHC class II protein complex	GO:042613	11.0	HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1
3	external side of plasma membrane	GO:009897	10.9	TLR4, CXCL10, CXCL9, CXCR3, ADA, CTLA4
4	ER to Golgi transport vesicle membrane	GO:012507	10.9	HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E
5	integral to lumenal side of endoplasmic reticulum membrane	GO:071556	10.9	HLA-G, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA
6	clathrin-coated endocytic vesicle membrane	GO:030669	10.7	HLA-DRB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DPA1, HLA-DPB1
7	trans-Golgi network membrane	GO:032588	10.7	HLA-DPB1, HLA-DRB5, HLA-DRB4, HLA-DQB1, HLA-DQA1, HLA-DQA2
8	transport vesicle membrane	GO:030658	10.6	HLA-DPB1, HLA-DRB1, HLA-DRB5, HLA-DRB4, HLA-DRB3, HLA-DRA
9	lysosomal membrane	GO:005765	10.6	HLA-DPB1, SLC17A5, HLA-DRB3, HLA-DRB1, HLA-DQB1, HLA-DQA2
10	MHC class I protein complex	GO:042612	10.5	HLA-G, HLA-A, HLA-B, HLA-C, HLA-E, HLA-F
11	endocytic vesicle membrane	GO:030666	10.4	HLA-DPB1, HLA-DQA2, HLA-DQA1, HLA-DPA1, HLA-DQB1, HLA-DRB1
12	DNA replication factor C complex	GO:005663	9.7	RFC5, RFC1, RFC3, RFC4, RFC2, PCNA
13	cell surface	GO:009986	9.6	TNFRSF1A, TNF, HMMR, HMGB1, CCR5, APOH
14	plasma membrane	GO:005886	9.1	TNFRSF8, TGFBI, PRTN3, PRF1, CXCR3, PECAM1
15	platelet alpha granule lumen	GO:031093	8.8	TGFB1, GAS6, TGFB3, VEGFA, F5, ALB
16	nucleoplasm	GO:005654	8.7	TYMS, OGG1, TDG, MUTYH, XRCC1, MPG
17	extracellular space	GO:005615	7.4	VCAM1, BMP6, CD14, CD40LG, MMP9, MICA
18	extracellular region	GO:005576	6.5	TGFB2, GAS6, TGFB3, TGFBI, TF, TFF3

Biological processes related to graft versus host disease according to GeneDecks:

(show top 50)    (show all 90)

id	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:006955	11.7	IL3, KIR2DL3, KIR2DL1, KIR2DS5, KIR3DL1, KIR2DS1
2	T cell costimulation	GO:031295	11.1	HLA-DQA1, HLA-DPB1, HLA-DPA1, ICOS, CD80, CD86
3	antigen processing and presentation of exogenous peptide antigen via MHC class II	GO:019886	11.1	HLA-DRB5, HLA-DMB, HLA-DOB, HLA-DOA, HLA-DPA1, HLA-DRB4
4	chemotaxis	GO:006935	11.1	HRG, CXCL10, CXCL11, CXCL9, CXCR3, CCL5
5	cell-cell signaling	GO:007267	11.0	CD86, TNFSF8, SST, LTA, LTB, TGFB2
6	regulation of immune response	GO:050776	11.0	KIR3DL2, KIR2DL1, KIR2DL3, KIR3DL1, KIR2DS1, KIR2DL2
7	positive regulation of interleukin-17 production	GO:032740	11.0	TGFB1, NOD2, IL23R, IL23A, IL2, IL18
8	base-excision repair, AP site formation	GO:006285	10.9	OGG1, TDG, SMUG1, NTHL1, MBD4, MPG
9	negative regulation of interferon-gamma production	GO:032689	10.9	GAS6, FOXP3, TNFSF4, IL10, HLA-DRB1, HLA-DRB3
10	positive regulation of T cell proliferation	GO:042102	10.9	CD28, PNP, TNFRSF13C, VCAM1, IFNG, CCL5
11	T-helper 1 type immune response	GO:042088	10.8	IL18BP, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL18
12	detection of bacterium	GO:016045	10.8	HLA-DRB4, HLA-DRB5, HLA-A, HLA-DRB1, HLA-B, NOD2
13	positive regulation of tumor necrosis factor production	GO:032760	10.8	CD36, CLEC7A, TLR4, CD14, IL18, NOD2
14	positive regulation of interferon-gamma production	GO:032729	10.7	TNF, IL23R, IL23A, IL1B, IL18, CD40LG
15	interferon-gamma-mediated signaling pathway	GO:060333	10.7	ICAM1, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1
16	cellular response to mechanical stimulus	GO:071260	10.7	IL18, IRF1, CD40, IL13, TLR4, IL1B
17	negative regulation of T cell proliferation	GO:042130	10.7	HLA-DRB3, IL10, FOXP3, TGFB1, HLA-G, HLA-DRB1
18	positive regulation of B cell proliferation	GO:030890	10.7	CD40LG, CD40, IL13, IL2, IL4, IL5
19	base-excision repair	GO:006284	10.6	FEN1, POLD1, MBD4, POLB, POLD2, MPG
20	positive regulation of interleukin-12 production	GO:032735	10.5	TNFSF4, HLA-G, IDO1, IFNG, IL23R, IL23A
21	response to lipopolysaccharide	GO:032496	10.5	IL1A, TNFRSF1A, IL18BP, IL13, FGF10, MMP9
22	nucleotide-excision repair, DNA gap filling	GO:006297	10.5	RFC4, POLE, POLB, RFC2, PCNA, RFC3
23	telomere maintenance via semi-conservative replication	GO:032201	10.5	RFC5, RFC4, RFC2, PCNA, LIG1, FEN1
24	telomere maintenance via recombination	GO:000722	10.5	RFC5, RFC4, RFC2, RFC1, RFC3, POLD2
25	positive regulation of inflammatory response	GO:050729	10.5	TLR4, TNFRSF1A, IL23A, IL2, IL18, CCL3
26	positive regulation of MHC class II biosynthetic process	GO:045348	10.4	TLR4, IL4, CD40LG, CIITA, IL10, IFNG
27	DNA strand elongation involved in DNA replication	GO:006271	10.4	RFC1, RFC2, RFC3, RFC4, FEN1, RFC5
28	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	10.4	LGALS9, CD36, CD40, FKBP1A, IL1A, TLR9
29	positive regulation of interleukin-10 production	GO:032733	10.4	IL23A, TLR4, CD40LG, TNFSF4, NOD2, TLR9
30	DNA repair	GO:006281	10.4	SMUG1, RFC1, RFC2, RFC3, NTHL1, MBD4
31	transcription-coupled nucleotide-excision repair	GO:006283	10.3	RFC1, PCNA, RFC2, POLE, POLD1, POLD2
32	cytokine-mediated signaling pathway	GO:019221	10.3	IL5, IL6, IFNG, IFNGR2, ICAM1, HLA-A
33	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.3	CCL3, IL1B, IL1A, FGF10, GAS6, TNF
34	telomere maintenance	GO:000723	10.2	RFC5, PCNA, RFC4, RFC3, RFC2, RFC1
35	inflammatory response	GO:006954	10.2	CXCL9, CXCL11, CXCL10, TGFB1, TLR9, CRP
36	nucleotide-excision repair	GO:006289	10.2	LIG1, RFC1, PCNA, RFC5, RFC4, RFC2
37	positive regulation of interleukin-6 production	GO:032755	10.2	TNFSF4, NOD2, TLR4, TLR9, IL1A, TNF
38	signal transduction	GO:007165	10.1	PECAM1, GAS6, CXCL9, IL10RA, FAS, CCL8
39	cellular response to lipopolysaccharide	GO:071222	10.1	TLR4, CD36, CD14, GSTP1, IL10, CCR5
40	aging	GO:007568	10.1	FAS, TIMP3, CCL5, IL15, VCAM1, IL1B
41	response to drug	GO:042493	9.9	SMPD1, PNP, LTA, ABCB1, TOP1, TGFB2
42	cell surface receptor signaling pathway	GO:007166	9.8	IFNG, CXCL10, CD28, CD36, CD14, CD4
43	DNA replication	GO:006260	9.7	RFC3, TYMS, EGF, PDGFB, CENPF, PCNA
44	positive regulation of cell proliferation	GO:008284	9.7	VEGFA, IL6, CD86, IL3, IL2, IL15
45	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.6	CD36, FGF10, CD80, CD4, IL11, VEGFA
46	positive regulation of apoptotic process	GO:043065	9.4	TGFB2, MMP9, IL1B, FASLG, FAS, IDO1
47	positive regulation of transcription from RNA polymerase II promoter	GO:045944	9.3	HMGB1, IL1A, IL17F, IL17A, IL6, FGF10
48	response to hypoxia	GO:001666	9.1	LTA, TLR4, TGFB1, TGFB3, PML, ADA
49	platelet degranulation	GO:002576	8.7	TGFB3, GAS6, HGF, PECAM1, TF, F13A1
50	platelet activation	GO:030168	8.1	THPO, TGFB1, F5, IL6, TGFB2, TGFB3

Molecular functions related to graft versus host disease according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	tumor necrosis factor receptor binding	GO:005164	10.9	TNFSF14, TNFSF8, LTB, LTA, TNFSF13B, TNFSF12
2	tumor necrosis factor-activated receptor activity	GO:005031	10.9	FAS, TNFRSF4, TNFRSF8, TNFRSF1B, TNFRSF1A, TNFRSF18
3	MHC class II receptor activity	GO:032395	10.8	HLA-DPA1, HLA-DOA, HLA-DOB, HLA-DQA1, HLA-DQA2, HLA-DQB1
4	damaged DNA binding	GO:003684	10.7	POLI, POLB, OGG1, TDG, XRCC1, PNKP
5	MHC class I receptor activity	GO:032393	10.6	HLA-A, HLA-B, HLA-E, HLA-F, HLA-G, HLA-C
6	cytokine activity	GO:005125	10.6	IL17F, HMGB1, TNF, TNFSF10, TNFSF12, TNFSF13B
7	receptor activity	GO:004872	10.4	KIR2DL1, FAS, F2RL1, KIR2DL3, CD86, CD4
8	receptor binding	GO:005102	10.4	ITGB7, MIF, FASLG, CXCL10, TGFB2, LTB
9	chemokine activity	GO:008009	10.4	CXCL11, CCL25, CCL3, CCL5, CXCL10, CXCL9
10	chemoattractant activity	GO:042056	10.3	FGF10, FGF7, VEGFA, MIF, HMGB1, CCL5
11	platelet-derived growth factor receptor binding	GO:005161	10.0	IL1R1, VEGFA, PDGFB, PDGFRB, PDGFRA
12	transmembrane signaling receptor activity	GO:004888	9.9	TLR4, KLRD1, TNFRSF8, ICAM1, IL18RAP, CD4
13	cell surface binding	GO:043498	9.9	PDGFB, VEGFA, MIF, ICAM1, F3, HRG
14	growth factor activity	GO:008083	9.0	HGF, IL10, FGF7, FGF10, BMP6, VEGFA
15	protein binding	GO:005515	5.3	TNFRSF1A, CCR5, MBD4, FAS, FASLG, APOH