MCID: GRF002
MIFTS: 64

Graft Versus Host Disease malady

Summaries for Graft Versus Host Disease

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Graft-versus-host disease (GVHD) is a common complication following an allogeneic tissue transplant. It... more...

MalaCards: Graft Versus Host Disease, also known as graft-versus-host disease, is related to acute graft versus host disease and chronic graft versus host disease. An important gene associated with Graft Versus Host Disease is IL2RA (interleukin 2 receptor, alpha), and among its related pathways are Akt Signaling and Allograft rejection. The compounds tyrosine and rapamycin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and lymph node, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Classifications for Graft Versus Host Disease

Sources:
31LifeMap Discovery™, 45Novoseek
See all sources

Aliases & Descriptions:

graft versus host disease 31 45
graft-versus-host disease 45


Related Diseases for Graft Versus Host Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Graft Versus Host Disease family:

acute graft versus host disease chronic graft versus host disease

Diseases related to Graft Versus Host Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 376)
idRelated DiseaseScoreTop Affiliating Genes
1acute graft versus host disease32.4THPO, HMHA1, KIR3DL1, IL2, IL2RB, IL1R1
2chronic graft versus host disease32.4CD28, CSF3
3acute leukemia31.5THPO, IL2, CSF3
4t-cell leukemia31.5IL2, IL2RB, IL2RA, CD28, LTA, FASLG
5vascular disease30.9IL2, IL10, FASLG, TNF
6aplastic anemia30.8THPO, FASLG, CSF3, GZMB, IFNG
7chronic myeloid leukemia30.8THPO, KIR3DL1, CSF3, GZMB
8lichen planus30.8GZMB
9hepatitis c30.7THPO, IL2, IL18, IL10, CD28, TNF
10hepatitis b30.7IL18, IL10, IL2RA, IFNG, CCR5
11thrombocytopenia30.7THPO, IL2, IL1R1, CSF3
12polymyositis30.7IL15, CD28, GZMB, CCR5
13thymoma30.7IL2, IL1R1, TNFRSF4
14pancytopenia30.7THPO, IL2RA, CSF3
15toxic epidermal necrolysis30.7FASLG, GZMB
16systemic lupus erythematosus30.5IL2, IL2RB, IL1R1, IL18, IL10, IL15
17atopic dermatitis30.5IL2, IL2RB, IL18, IL10, IL2RA, LTA
18uveitis30.5IL1R1, IL10, IL2RA, LTA, TNF, IFNG
19lupus nephritis30.5IL18, IL10, IL2RA, LTA, CCR5
20nephritis30.5IL1R1, IL18, LTA
21aspergillosis30.5IFNG
22sepsis30.3IL1R1, IL18, IL10, IL15, LTA, TNF
23myelodysplastic syndromes30.3THPO, KIR3DL1, FASLG, CSF3, GZMB
24peripheral t-cell lymphoma30.3IL2RB, IL2RA, LTA, GZMB
25anaplastic large cell lymphoma30.3IL2RB, IL2RA, GZMB
26acute pancreatitis30.3IL1R1, IL18, IL10
27oral cancer30.3FASLG
28hepatitis e30.3TNFRSF4
29hematopoietic stem cell transplantation11.3
30acute t cell leukemia10.9
31leukemia, t-cell, chronic10.8
32bronchiolitis obliterans10.7
33bronchiolitis10.7
34acute myeloid leukemia10.7
35n syndrome10.7
36adult t-cell leukemia10.6
37vaginal disease10.6
38graft-versus-host disease, protection against10.6
39corneal disease10.6
40erythema multiforme10.6
41bone marrow necrosis10.6
42engraftment syndrome10.6
43cytomegalovirus infection10.6
44acute diarrhea10.5
45hepatitis d10.5
46hepatitis a10.5
47lichen sclerosus10.5
48bronchiolitis obliterans organizing pneumonia10.5
49blood protein disease10.5
50bone development disease10.5

Graphical network of the top 20 diseases related to Graft Versus Host Disease:



Diseases related to graft versus host disease

Clinical Features for Graft Versus Host Disease

Drugs & Therapeutics for Graft Versus Host Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Graft Versus Host Disease

Drug clinical trials:

Search ClinicalTrials for Graft Versus Host Disease

Search NIH Clinical Center for Graft Versus Host Disease

Search CenterWatch for Graft Versus Host Disease

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Graft Versus Host Disease cell therapies at LifeMap Discovery.

Genetic Tests for Graft Versus Host Disease

Anatomical Context for Graft Versus Host Disease

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Graft Versus Host Disease:

33
Bone marrow, Whole blood, Lymph node, Spleen, Thymus, Heart, Small intestine, Colon, Kidney, Liver, Lung, Pancreas, Thyroid, Salivary gland, Breast, Skin, Placenta, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Tongue, Fetal liver, Fetal lung, Fetal thyroid

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Graft Versus Host Disease:
id TissueAnatomical CompartmentCell Relevance
1 BoneBone MarrowBone Marrow Stromal Cells Potential therapeutic candidate

Animal Models for Graft Versus Host Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Graft Versus Host Disease

Sources:
51PubMed
See all sources

Articles related to Graft Versus Host Disease:

(show top 50)    (show all 1669)
idTitleAuthorsYear
1
Vorinostat plus tacrolimus and mycophenolate to prevent graft-versus-host disease after related-donor reduced-intensity conditioning allogeneic haemopoietic stem-cell transplantation: a phase 1/2 trial. (24295572)
2014
2
Robust and cost effective expansion of human regulatory T cells highly functional in a xenograft model of graft-versus-host disease. (23242592)
2013
3
Mouse T cells engineered to display on their surface a novel form of FasL protein undergo apoptosis when stimulated with alloantigens: implications for graft-versus-host disease. (23769056)
2013
4
Factors associated with bronchiolitis obliterans syndrome and chronic graft versus host disease after allogeneic hematopoietic cell transplantation. (24375545)
2013
5
Localized edema with sclerodermatous evolution: a possible form of skin chronic graft-versus-host disease associated with endothelial activation. (23869081)
2013
6
Effector T cells require fatty acid metabolism during murine graft-versus-host disease. (24046012)
2013
7
Diagnosis and evaluation of intestinal graft-versus-host disease after allogeneic hematopoietic stem cell transplantation following reduced-intensity and myeloablative conditioning regimens. (23435651)
2013
8
Anti-thymocyte globulins for post-transplant graft-versus-host disease prophylaxis-A systematic review and meta-analysis. (23561334)
2013
9
Response endpoints and failure-free survival after initial treatment for acute graft-versus-host disease. (24056814)
2013
10
Keratinocyte-derived amyloidosis as a manifestation of chronic graft-versus-host disease. (23899263)
2013
11
Graft-versus-host disease after double-unit cord blood transplantation has unique features and an association with engrafting unit-to-recipient HLA match. (23416854)
2013
12
Acute graft-versus-host disease biomarkers measured during therapy can predict treatment outcomes: a Blood and Marrow Transplant Clinical Trials Network study. (22383800)
2012
13
Influence of NK cell S1PR5 expression on graft versus host disease in allogeneic hematopoietic stem cell transplantation]. (22541110)
2012
14
Evaluation of prognostic factors among patients with chronic graft-versus-host disease. (22371184)
2012
15
Impaired aortic elastic properties in patients with chronic graft-versus-host disease. (21854427)
2011
16
German-Austrian-Swiss Consensus Conference on clinical practice in chronic graft-versus-host disease (GVHD): guidance for supportive therapy of chronic cutaneous and musculoskeletal GVHD. (21466534)
2011
17
Comments on Brazilian workshop model for training investigators in chronic graft-versus-host disease according to the 2005-2006 National Institutes of Health recommendations. (23049333)
2011
18
Early and late extensive chronic graft-versus-host disease in children is characterized by different Th1/Th2 cytokine profiles: findings of the Children's Oncology Group Study ASCT0031. (21669298)
2011
19
Diagnosis and staging of chronic graft-versus-host disease in the clinical practice. (20691801)
2011
20
Pharmacologic expansion of donor-derived, naturally occurring CD4(+)Foxp3(+) regulatory T cells reduces acute graft-versus-host disease lethality without abrogating the graft-versus-leukemia effect in murine models. (21145405)
2011
21
Progress in chronic graft-versus-host disease. (23049313)
2011
22
Oral chronic graft-versus-host disease: report from the International Consensus Conference on clinical practice in cGVHD. (20859645)
2011
23
Possible role of engraftment syndrome and autologous graft-versus-host disease in myelodysplastic syndrome after autologous stem cell transplantations: retrospective analysis and review of the literature. (20371446)
2010
24
Consensus conference on clinical practice in chronic graft-versus-host disease (GVHD): first-line and topical treatment of chronic GVHD. (20601036)
2010
25
Idiopathic pneumonia syndrome in mice after allogeneic bone marrow transplantation: association between idiopathic pneumonia syndrome and acute graft-versus-host disease. (20226241)
2010
26
Eosinophilia predicts better overall survival after acute graft-versus-host-disease. (19525984)
2010
27
Evaluation of mycophenolate mofetil for initial treatment of chronic graft-versus-host disease. (19270260)
2009
28
Acute graft-versus-host disease after liver transplant: novel use of etanercept and the role of tumor necrosis factor alpha inhibitors. (19326415)
2009
29
Intestinal trefoil factor maybe useful in prophylaxis of acute graft-versus-host disease. (19564083)
2009
30
Donor-recipient mismatch for common gene deletion polymorphisms in graft-versus-host disease. (19935662)
2009
31
Drug rash with eosinophilia and systemic symptoms and graft-versus-host disease developing sequentially in a patient. (18793307)
2009
32
Third party mesenchymal stromal cell infusions fail to induce tissue repair despite successful control of severe grade IV acute graft-versus-host disease in a child with juvenile myelo-monocytic leukemia. (17972946)
2008
33
Sclerodermatous chronic graft-versus-host disease--a report of four pediatric cases. (18429789)
2008
34
Soluble human leucocyte antigen-G molecules in peripheral blood haematopoietic stem cell transplantation: a specific role to prevent acute graft-versus-host disease and a link with regulatory T cells. (18241225)
2008
35
Phase II study of pentostatin in patients with corticosteroid-refractory chronic graft-versus-host disease. (17878478)
2007
36
The management and outcome of chronic graft-versus-host disease. (17593020)
2007
37
Histological evaluation of acute mucocutaneous graft-versus-host disease in nonmyeloablative hematologic stem cell transplants with an observation predicting an increased risk of progression to chronic graft-versus-host disease. (17284954)
2007
38
Quality of life associated with acute and chronic graft-versus-host disease. (16819438)
2006
39
Novel strategies for steroid-refractory acute graft-versus-host disease. (15604890)
2005
40
Treatment of Gastrointestinal Acute Graft-Versus-Host Disease. (15913514)
2005
41
Recipients who receive a human leukocyte antigen-B compatible cadaveric liver allograft are at high risk of developing acute graft-versus-host disease. (15614155)
2004
42
Infliximab treatment for steroid-refractory acute graft-versus-host disease. (15531458)
2004
43
Autologous peripheral blood stem cell transplantation with induction of autologous graft-versus-host disease in acute myeloid leukemia. (14561989)
2003
44
Chloroquine prevention of murine MHC-disparate acute graft-versus-host disease correlates with inhibition of splenic response to CpG oligodeoxynucleotides and alterations in T-cell cytokine production. (12523576)
2002
45
Hepatitic variant of graft-versus-host disease after donor lymphocyte infusion. (12393729)
2002
46
Murine sclerodermatous graft-versus-host disease, a model for human scleroderma: cutaneous cytokines, chemokines, and immune cell activation. (11884483)
2002
47
Both genetic and clinical factors predict the development of graft-versus-host disease after allogeneic hematopoietic stem cell transplantation. (11544434)
2001
48
Irreversible loss of donor blood leucocyte activation may explain a paucity of transfusion-associated graft-versus-host disease from stored blood. (11091195)
2000
49
Close simulation of acute graft-versus-host disease by interleukin-2 administered after autologous bone marrow transplantation for hematologic malignancy. (8704686)
1996
50
Soluble CD8, IL-2 receptor, and tumor necrosis factor-alpha levels in steroid-resistant acute graft-versus-host disease. Relation with subsequent response to anti-IL-2 receptor monoclonal antibody treatment. (1910217)
1991

Genetic Variations for Graft Versus Host Disease

Expression for genes affiliated with Graft Versus Host Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Graft Versus Host Disease

Search GEO for disease gene expression data for Graft Versus Host Disease.

Pathways for genes affiliated with Graft Versus Host Disease

Sources:
52QIAGEN, 30KEGG, 12EMD Millipore, 38NCBI BioSystems Database, 53R&D Systems, 54Reactome, 4Cell Signaling Technology
See all sources

Pathways related to Graft Versus Host Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.7THPO, CCR5, CSF3, TNF, TNFRSF4, LTA
2
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11.3IFNG, GZMB, TNF, FASLG, LTA, CD28
3
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11.3IFNG, TNF, FASLG, LTA, CD28, IL2RA
4
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11.2IL2, IL2RB, CCR5, IFNG, GZMB, FASLG
5
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11.2GZMB, TNF, FASLG, IL2RA, IL15, IL10
6
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11.2CSF3, TNFRSF4, LTA, CD28, IL2RA, IL15
711.2IFNG, GZMB, TNF, TNFRSF4, FASLG, IL2RA
8
Hide members
11.2CCR5, TNFRSF4, THPO, IL2RB, IL18, IL15
9
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11.1IFNG, CD28, IL2RA, IL18, IL1R1, IL2RB
10
Hide members
11.1TNF, LTA, IL2RA, IL15, IL2RB, IL2
1111.1IFNG, CSF3, IL2RA, IL15, IL10, IL2RB
12
Hide members
11.1CCR5, CSF3, TNFRSF4, FASLG, CD28, IL2RA
1311.1IL18, IL10, IL15, LTA, TNF, IFNG
14
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11.1IFNG, TNF, LTA, CD28, IL10, IL18
15
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11.0IFNG, TNF, IL2RA, IL1R1, IL2RB, IL2
16
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11.0IFNG, IL2RA, IL18, IL1R1, IL2RB, IL2
17
Hide members
11.0IFNG, GZMB, TNF, FASLG, IL2, KIR3DL1
1811.0GZMB, FASLG, IL2RA, IL10, IL2RB, IL2
19
Hide members
11.0CCR5, IFNG, TNF, CD28, IL10, IL2
20
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10.9IFNG, TNF, FASLG, IL2RA, IL2
21
Hide members
10.9GZMB, TNF, FASLG, LTA, IL1R1
2210.9IFNG, TNF, FASLG, IL10, IL18
23
Hide members
10.9IL2RA, IL18, IL1R1, IL2RB, IL2
24
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10.9FASLG, LTA, IL2RA, IL2RB, IL2
25
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10.9IL2, IL10, FASLG, TNF, IFNG
2610.9CSF3, TNF, IL2RA, IL1R1, THPO
2710.9IL2, IL2RB, IL2RA, FASLG, CSF3
2810.9IL2RA, IL15, IL1R1, IL2RB, IL2
2910.9IFNG, TNFRSF4, LTA, IL10, IL2
30
Development PDGF signaling via STATs and NF-kB
Hide members
10.9IFNG, TNF, IL10, IL18, IL2
3110.9IL2, IL2RB, IL2RA, CD28, IFNG
32
Hide members
10.9LTA, IL2RA, IL2RB, IL2, THPO
3310.9IFNG, CD28, IL2RA, IL18, IL2
34
Immune response Bacterial infections in normal airways
Hide members
10.8IFNG, TNF, FASLG, IL1R1
35
Hide members
10.8TNF, TNFRSF4, LTA, IL1R1
3610.8IFNG, TNF, IL10, IL1R1
37
Hide members
10.8IL1R1, LTA, FASLG, TNF
38
Hide members
10.8IFNG, IL2RA, IL2RB, IL2
39
Hide members
10.8TNF, LTA, IL1R1, THPO
40
Hide members
10.8LTA, FASLG, TNF, CCR5
4110.8TNF, LTA, CD28, IL1R1
42
Hide members
10.8CD28, IL2RA, IL2RB, IL2
4310.8IL2, IL2RB, IL2RA, CD28
4410.7IL2, IL1R1, TNF
4510.7IFNG, TNF, IL2
46
Hide members
10.7IL1R1, CD28, GZMB
47
Hide members
10.7CCR5, IFNG, LTA
4810.7IL18, IL15, CD28
49
Hide members
10.6IL18, CCR5
5010.6IL18

Compounds for genes affiliated with Graft Versus Host Disease

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Graft Versus Host Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 188)
idCompoundScoreTop Affiliating Genes
1tyrosine4512.1KIR3DL1, IL2, CSF3, CCR5, IL15, GZMB
2rapamycin4512.0IL2RB, IL2, THPO, IL1R1, IL18, CCR5
3ionomycin4511.9IL18, IL10, IL2RB, IL2, IL15, LTA
4thymidine45 2412.9IFNG, CSF3, TNF, FASLG, IL2RA, IL15
5rantes4511.9THPO, IL2, IFNG, GZMB, CSF3, TNF
6vegf4511.9GZMB, CSF3, TNF, FASLG, LTA, IL2RA
7tacrolimus45 50 1113.9IL2RA, IL15, IL10, IL18, IL2RB, IL2
8il 104511.9CCR5, IL2, IFNG, TNF, LTA, IL2RA
9retinoic acid45 2412.8TNF, THPO, CSF3, IL2RB, CCR5, IL1R1
10cyclosporin a45 29 6013.8GZMB, CSF3, TNFRSF4, LTA, CD28, IL2RA
11neopterin4511.7LTA, TNF, GZMB, IFNG, IL18, IL2
12infliximab45 50 1113.7IL10, IL2RA, LTA, TNF, IL15, IL1R1
13histamine45 29 2413.7THPO, CCR5, TNF, IL2RA, IL15, IL10
14nitric oxide45 11 2413.7LTA, IL15, GZMB, IL10, IL18, IL1R1
15okt34511.6IL2RB, IL2, IL10, IL15, IFNG, TNF
16methotrexate45 50 1113.6IL18, CSF3, TNF, FASLG, IL2RA, IL15
17etanercept45 50 1113.6IL2RB, IL1R1, TNF, IL18, IL10, IL15
18ccl345 2912.6TNF, CSF3, IFNG, CCR5, IL10, IL18
19rituximab45 50 1113.5IL2RA, IL1R1, CSF3, IL10, IL15, TNF
20thalidomide45 50 60 1114.5IL18, IL10, IL2RA, FASLG, TNF, IFNG
21il-124511.5IL2, IL1R1, IL18, IL10, IL15, TNF
22cyclophosphamide45 50 1113.5FASLG, IL2RA, CSF3, IL15, IL2, IL2RB
23con a4511.5IL2RA, CD28, IFNG, IL2RB, IL10, IL18
24mycophenolate mofetil45 50 1113.4IFNG, IL2RB, IL2, IL10, IL2RA, CSF3
25ifn-alpha4511.4IL2RB, IL18, IL10, IL2RA, FASLG, IL2
265fluorouracil4511.4IFNG, FASLG, CSF3, IL2RA, IL15, IL18
27chloroquine45 2 50 29 1115.4IL1R1, IL2, IL18, IL10, IL15, IL2RA
28prednisolone45 29 1113.3GZMB, LTA, IL2RA, IL1R1, IL2RB
29dexamethasone45 50 29 1114.3IL1R1, IL15, LTA, FASLG, GZMB
30polyinosinic-polycytidylic acid4511.3IL18, IL10, IL15, IL2, IFNG, TNF
31gm-csf45 2912.3IFNG, TNF, IL10, THPO
32ivig4511.3CCR5, IFNG, IL1R1, IL2RB
33pentoxifylline45 1112.2LTA, IL18, IL1R1, IL2RB
34alpha-galactosylceramide4511.2IL15, IFNG, GZMB, IL2, IL10
35tgf beta14511.2TNF, IL18, IL10, THPO, IL15, LTA
36cycloheximide4511.2IL18, LTA, FASLG, IL2RB
37ribavirin45 50 1113.2IL10, IL2, IL18, CSF3, IFNG, CCR5
38tuberculin4511.1IL15, IL10, IL18, IFNG, IL2RA
39gold sodium thiomalate4511.1IFNG, TNF, IL2RA, IL1R1, IL2
40natalizumab45 1112.1IL10, IL2RA, IFNG, TNF, IL18
412,5-oligoadenylate4511.1TNF, IL2, IL2RB, IL2RA
42actinomycin d4511.1FASLG, TNF, THPO, IL2, IL1R1, LTA
43endotoxin4511.0FASLG, CSF3
44imiquimod45 29 60 1114.0TNF, IL10, IL18, IFNG, FASLG
45pge24511.0IL2
46lipoteichoic acid4510.9IL1R1, IL10, LTA, TNF, IL18
47indomethacin45 60 29 1113.9IL1R1
48chromium4510.9KIR3DL1, IL2RB, GZMB
49interferon gamma4510.8TNF, IL2, IL10, IFNG
50ctla4-ig4510.5IL2RB, IL15, CD28, IL2

GO Terms for genes affiliated with Graft Versus Host Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Graft Versus Host Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588711.2TNF, TNFRSF4, FASLG, CD28, IL15, IL1R1
2external side of plasma membraneGO:00989711.1IL2RB, CCR5, IFNG, TNF, TNFRSF4, FASLG
3extracellular spaceGO:00561511.0IFNG, CSF3, TNF, FASLG, LTA, IL15

Biological processes related to Graft Versus Host Disease according to GeneCards/GeneDecks:

(show all 35)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.7KIR3DL1, CCR5, CSF3, TNFRSF4, FASLG, IL2RA
2cell-cell signalingGO:00726711.5CCR5, FASLG, LTA, IL15, IL10, IL18
3inflammatory responseGO:00695411.4CCR5, TNF, TNFRSF4, IL15, IL10, IL18
4apoptotic processGO:00691511.3IFNG, GZMB, TNF, FASLG, LTA, IL2RA
5cell surface receptor signaling pathwayGO:00716611.3CCR5, IFNG, CD28, IL2RA, IL1R1
6response to drugGO:04249311.3IFNG, TNF, LTA, IL10, CENPF
7positive regulation of transcription from RNA polymerase II promoterGO:04594411.2IL2, IL10, CD28, TNF, CSF3, IFNG
8negative regulation of growth of symbiont in hostGO:04413011.2IL10, LTA, TNF, IFNG
9positive regulation of interferon-gamma productionGO:03272911.2TNF, LTA, IL18, IL2
10humoral immune responseGO:00695911.2IFNG, TNF, LTA, CD28
11cellular response to lipopolysaccharideGO:07122211.2CCR5, IFNG, CSF3, IL10
12positive regulation of isotype switching to IgG isotypesGO:04830411.1IFNG, CD28, IL2
13positive regulation of tissue remodelingGO:03410511.1IL15, IL18, IL2
14positive regulation of interleukin-17 productionGO:03274011.1IL2, IL18, IL15
15positive regulation of activated T cell proliferationGO:04210411.1IL2, IL18, IL2RA
16positive regulation of neuron apoptotic processGO:04352511.0IL18, FASLG, TNF
17positive regulation of vitamin D biosynthetic processGO:06055711.0IFNG, TNF
18positive regulation of T cell proliferationGO:04210211.0IL15, CD28, IFNG
19regulation of T cell homeostatic proliferationGO:04601311.0IL2RA, IL2
20positive regulation of chronic inflammatory response to antigenic stimulusGO:00287611.0TNF, LTA
21positive regulation of inflammatory responseGO:05072911.0IL15, IL18, IL2
22positive regulation of calcidiol 1-monooxygenase activityGO:06055911.0IFNG, TNF
23activation of necroptosis by extracellular signalsGO:06055511.0TNF, FASLG
24receptor biosynthetic processGO:03280011.0TNF, IL10
25type 2 immune responseGO:04209210.9IL10, IL18
26necrotic cell deathGO:07026510.9TNF, FASLG
27negative regulation of cytokine secretion involved in immune responseGO:00274010.8TNF, IL10
28MAPK cascadeGO:00016510.8CCR5, TNF, IL18
29positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00292510.8LTA, TNF
30positive regulation of natural killer cell proliferationGO:03281910.8IL18, IL15
31positive regulation of MHC class II biosynthetic processGO:04534810.7IL10, IFNG
32positive regulation of immunoglobulin secretionGO:05102410.6IL2, TNFRSF4
33lymph node developmentGO:04853510.6IL15, LTA
34positive regulation of chemokine biosynthetic processGO:04508010.6IFNG, TNF
35positive regulation of apoptotic processGO:04306510.5IL2RA, LTA, FASLG, TNF

Molecular functions related to Graft Versus Host Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512511.4THPO, IFNG, CSF3, TNF, FASLG, LTA
2tumor necrosis factor receptor bindingGO:00516410.8TNF, FASLG, LTA
3protease bindingGO:00202010.7IL1R1, CD28, TNF
4interleukin-2 receptor activityGO:00491110.7IL2RB, IL2RA
5interleukin-2 bindingGO:01997610.6IL2RB, IL2RA
6growth factor activityGO:00808310.5CSF3, IL10, IL2, THPO

Products for genes affiliated with Graft Versus Host Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Graft Versus Host Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet