MCID: GRH005
MIFTS: 24

Graham-Little-Piccardi-Lassueur Syndrome

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Graham-Little-Piccardi-Lassueur Syndrome

MalaCards integrated aliases for Graham-Little-Piccardi-Lassueur Syndrome:

Name: Graham-Little-Piccardi-Lassueur Syndrome 49
Graham Little-Piccardi-Lassueur Syndrome 49 55
Piccardi-Lassueur-Little Syndrome 49 55
Graham Little Syndrome 49 55
Lichen Planus Follicularis 69

Characteristics:

Orphanet epidemiological data:

55
graham little-piccardi-lassueur syndrome
Age of onset: Adult; Age of death: normal life expectancy;

Classifications:

Orphanet: 55  
Rare skin diseases


External Ids:

Orphanet 55 ORPHA505
ICD10 via Orphanet 33 L66.1
UMLS 69 C0023645

Summaries for Graham-Little-Piccardi-Lassueur Syndrome

NIH Rare Diseases : 49 Graham-Little-Piccardi-Lassueur syndrome (GLPLS) is a rare type of scarring hair loss. It is most commonly found in otherwise healthy women between the ages of 30 and 70 years. GLPLS is characterized by three features: progressive patchy scarring hair loss of the scalp (cicatricial alopecia), non-scarring thinning of the hair in the armpits and groin (noncicatricial alopecia), and spiky rough bumps based around hair follicles (follicular lichen planus). Sometimes individuals with GLPLS experience itching around affected areas, which can be severe. The cause of this condition is not known; however, over the years, researchers have suggested theories that it may develop in relation to genetic factors, viral exposures, hormonal changes, immune system issues, stress, and vitamin deficiencies. Treatment focuses on slowing the progression of hair loss and may include corticosteroids, retinoids (medications related to vitamin A), psoralen plus ultraviolet light A (PUVA), antimalarial medications, and antibiotics.  Last updated: 3/23/2017

MalaCards based summary : Graham-Little-Piccardi-Lassueur Syndrome, also known as graham little-piccardi-lassueur syndrome, is related to androgen insensitivity syndrome and lichen planus, and has symptoms including pruritus, alopecia and sparse scalp hair. An important gene associated with Graham-Little-Piccardi-Lassueur Syndrome is HLA-DRA (Major Histocompatibility Complex, Class II, DR Alpha). Affiliated tissues include skin, and related phenotype is Increased G1 DNA content.

Related Diseases for Graham-Little-Piccardi-Lassueur Syndrome

Diseases related to Graham-Little-Piccardi-Lassueur Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 androgen insensitivity syndrome 10.6
2 lichen planus 10.5
3 alopecia 10.2
4 frontal fibrosing alopecia 10.2
5 cutaneous lupus erythematosus 10.0
6 lupus erythematosus 10.0
7 lichen planopilaris 10.0

Graphical network of the top 20 diseases related to Graham-Little-Piccardi-Lassueur Syndrome:



Diseases related to Graham-Little-Piccardi-Lassueur Syndrome

Symptoms & Phenotypes for Graham-Little-Piccardi-Lassueur Syndrome

Human phenotypes related to Graham-Little-Piccardi-Lassueur Syndrome:

55 31 (show all 7)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 pruritus 55 31 frequent (33%) Frequent (79-30%) HP:0000989
2 alopecia 55 31 hallmark (90%) Very frequent (99-80%) HP:0001596
3 sparse scalp hair 55 31 hallmark (90%) Very frequent (99-80%) HP:0002209
4 sparse axillary hair 55 31 hallmark (90%) Very frequent (99-80%) HP:0002215
5 sparse pubic hair 55 31 hallmark (90%) Very frequent (99-80%) HP:0002225
6 perifollicular hyperkeratosis 55 31 hallmark (90%) Very frequent (99-80%) HP:0007468
7 lichenification 55 31 frequent (33%) Frequent (79-30%) HP:0100725

GenomeRNAi Phenotypes related to Graham-Little-Piccardi-Lassueur Syndrome according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased G1 DNA content GR00098-A-1 8.62 HLA-DRA INCENP

Drugs & Therapeutics for Graham-Little-Piccardi-Lassueur Syndrome

Search Clinical Trials , NIH Clinical Center for Graham-Little-Piccardi-Lassueur Syndrome

Genetic Tests for Graham-Little-Piccardi-Lassueur Syndrome

Anatomical Context for Graham-Little-Piccardi-Lassueur Syndrome

MalaCards organs/tissues related to Graham-Little-Piccardi-Lassueur Syndrome:

38
Skin

Publications for Graham-Little-Piccardi-Lassueur Syndrome

Articles related to Graham-Little-Piccardi-Lassueur Syndrome:

# Title Authors Year
1
Graham Little-Piccardi-Lassueur syndrome in a patient with androgen insensitivity syndrome. ( 26566966 )
2015
2
Graham-Little Piccardi Lassueur syndrome: case report. ( 23044575 )
2012
3
Graham-Little-Piccardi-Lassueur syndrome. ( 22031656 )
2011
4
Graham-little piccardi lassueur syndrome: an unusual variant of follicular lichen planus. ( 21769233 )
2011
5
Autoantibodies against the chromosomal passenger protein INCENP found in a patient with Graham Little-Piccardi-Lassueur syndrome. ( 17222351 )
2007
6
Graham Little-Piccardi-Lassueur syndrome associated with androgen insensitivity syndrome (testicular feminization). ( 15196163 )
2004
7
Graham Little-Piccardi-Lassueur syndrome: effective treatment with cyclosporin A. ( 11678880 )
2001

Variations for Graham-Little-Piccardi-Lassueur Syndrome

Expression for Graham-Little-Piccardi-Lassueur Syndrome

Search GEO for disease gene expression data for Graham-Little-Piccardi-Lassueur Syndrome.

Pathways for Graham-Little-Piccardi-Lassueur Syndrome

GO Terms for Graham-Little-Piccardi-Lassueur Syndrome

Sources for Graham-Little-Piccardi-Lassueur Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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