MCID: GRN010
MIFTS: 48

Granular Cell Tumor malady

Cancer category

Summaries for Granular Cell Tumor

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Granular cell tumor is a tumor that can develop on any skin or mucosal surface, but occurs on the tongue... more...

MalaCards: Granular Cell Tumor, also known as neoplasm of granular cell, is related to adenocarcinoma and squamous cell carcinoma. An important gene associated with Granular Cell Tumor is S100B (S100 calcium binding protein B), and among its related pathways is Neuroscience. The compounds estrogen and glycogen have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, heart and colon, and related mouse phenotype behavior/neurological.

Aliases & Classifications for Granular Cell Tumor

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer


Aliases & Descriptions:

granular cell tumor 8 10 45 61
neoplasm of granular cell 8
granular cell tumor nos 8


External Ids:

Disease Ontology8 DOID:2411
NCIt40 C3474
MeSH35 D016586

Related Diseases for Granular Cell Tumor

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Granular Cell Tumor family:

congenital granular cell tumor

Diseases related to Granular Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 198)
idRelated DiseaseScoreTop Affiliating Genes
1adenocarcinoma30.7VIM, CALB2, SYP, NTRK1, NGFR, INHA
2squamous cell carcinoma30.6VIM, CALB2, S100A1, SYP, NTRK1, NGFR
3gastrointestinal stromal tumor30.3VIM, S100B, S100A1, DES, ENO2
4alveolar soft part sarcoma30.1VIM, DES, ENO2
5spindle cell carcinoma30.1DES, VIM
6paraganglioma30.1S100B, S100A1, SYP, ENO2
7breast granular cell tumor11.0
8congenital granular cell tumor10.8
9myoblastoma10.7
10granular cell carcinoma10.7
11neurohypophysis granular cell tumor10.7
12congenital epulis10.6
13vulvar granular cell tumor10.5
14skin granular cell tumor10.5
15n syndrome10.4
16noonan syndrome10.4
17malignant gastric granular cell tumor10.4
18malignant granular cell myoblastoma10.4
19leopard syndrome10.2
20malignant granular cell skin tumor10.2
21heart tumor10.2
22esophageal squamous cell carcinoma10.2
23pituicytoma10.2
24acalculous cholecystitis10.1
25eosinophilic esophagitis10.1
26mediastinal granular cell myoblastoma10.1
27cardiac granular cell neoplasm10.1
28malignant granular cell esophageal tumor10.1
29acromegaly10.1
30appendicitis10.1
31pulmonary coin lesion10.1
32granular cell leiomyosarcoma10.1
33churg-strauss syndrome10.1
34bronchogenic carcinoma10.1
35vitiligo10.1
36intraneural perineurioma10.1
37bladder adenocarcinoma10.1
38tuberculosis10.1
39short syndrome10.1
40bronchogenic cyst10.1
41eagle syndrome10.1
42odontogenic myxoma10.1
43prurigo nodularis10.1
44dysphagia10.1
45pituitary tumors10.1
46short stature10.1
47gastric outlet obstruction10.1
48benign peripheral nerve sheath tumor10.1
49choristoma10.1
50cerebral primitive neuroectodermal tumor10.0ENO2

Graphical network of the top 20 diseases related to Granular Cell Tumor:



Diseases related to granular cell tumor

Clinical Features for Granular Cell Tumor

Drugs & Therapeutics for Granular Cell Tumor

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Granular Cell Tumor

Drug clinical trials:

Search ClinicalTrials for Granular Cell Tumor

Search NIH Clinical Center for Granular Cell Tumor

Search CenterWatch for Granular Cell Tumor

Genetic Tests for Granular Cell Tumor

Anatomical Context for Granular Cell Tumor

Sources:
33MalaCards
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MalaCards organs/tissues related to Granular Cell Tumor:

33
Spinal cord, Heart, Colon, Kidney, Lung, Pancreas, Thyroid, Breast, Skin, Uterus, Prostate, Testis, Cervix, T cells, Tongue, Fetal lung, Trachea, Bronchial epithelium, Appendix, Fetal thyroid, Pituitary, Uterus corpus

Animal Models for Granular Cell Tumor or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Granular Cell Tumor:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053869.3ENO2, CALB2, S100B, S100A1, UCHL1, MPZ

Publications for Granular Cell Tumor

Sources:
51PubMed
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Articles related to Granular Cell Tumor:

(show top 50)    (show all 563)
idTitleAuthorsYear
1
Granular cell tumor of the vulva. (22885645)
2013
2
Granular cell tumor of the vulva: retraction. (23803806)
2013
3
Pathology quiz case 1. Diagnosis: multifocal granular cell tumor (GCT). (23069833)
2012
4
Granular cell tumor of the esophagus in an adolescent girl. (22157926)
2012
5
One case, 3 rare simultaneous findings: intramyocardial bronchogenic cyst, P.H558R variant of SCN5A gene, and granular cell tumor of the esophagus. (22835975)
2012
6
Atypical meningeal granular cell tumor in a dog. (22362953)
2012
7
Malignant granular cell tumor of the thigh. (21815590)
2011
8
The importance of fine needle aspiration in conjunction with radiologic examination in the evaluation of granular cell tumor presenting as a thyroid mass: a case report. (21326815)
2011
9
Cystic granular cell tumor mimicking Rathke cleft cyst. (20509726)
2011
10
Pituicytoma, spindle cell oncocytoma, and granular cell tumor: clarification and meta-analysis of the world literature since 1893. (21960498)
2011
11
Granular cell tumor of the breast: clinical and pathologic characteristics of a rare case in a 14-year-old girl. (21646617)
2011
12
Acute appendicitis secondary to a granular cell tumor of the appendix in a 19-year-old male. (21533589)
2011
13
Diagnosis of malignant granular cell tumor metastatic to bone by fine needle aspiration cytology: a case report. (20391977)
2010
14
Isolated intra-oral granular cell tumor: report of two cases and review of the literature. (21053681)
2010
15
Gastric Abrikosoff tumor (granular cell tumor): case report. (20939949)
2010
16
Colorectal granular cell tumor: a clinicopathologic study of 26 cases. (20661017)
2010
17
Tongue nodule. Granular cell tumor. (20591783)
2010
18
Cutaneous granular cell tumor of the breast: a clinical diagnostic pitfall. (21629537)
2010
19
Esophageal granular cell tumor treated by endoscopic mucosal resection. (19828958)
2009
20
Granular cell tumor of the oral cavity: updated immunohistochemical profile. (19192059)
2009
21
Congenital granular cell epulis presents an immunohistochemical profile that distinguishes it from the granular cell tumor of the adult. (19205730)
2009
22
Congenital granular cell tumor. (19461349)
2009
23
Granular cell tumor of the descending colon treated by endoscopic mucosal resection: a case report and review of the literature. (19399282)
2009
24
Immunohistochemical expression of Galectin-3 and HBME-1 in granular cell tumors: a new finding. (18581283)
2008
25
Granular cell tumor of the scrotum. (16150233)
2005
26
Granular cell tumor of the breast. (16297125)
2005
27
Fine needle aspiration biopsy of intrabronchial granular cell tumor. (15839633)
2005
28
Granular cell tumor of the trachea in a child. (15680798)
2005
29
Granular cell tumor of the biliary system: a report of 2 cases with cytologic diagnosis on endoscopic brushing. (15839629)
2005
30
Granular cell tumor of the tongue (Abrikossoff's tumor). A case report and review of the literature. (15278025)
2004
31
Neuroimaging findings in a suprasellar granular cell tumor. (12544238)
2003
32
Granular cell tumor occurring in the sigmoid colon treated by endoscopic mucosal resection using a transparent cap (EMR-C). (12743780)
2003
33
Granular cell tumor of the parotid gland. A case report. (12040652)
2002
34
Concomitant triple lesions of adenocarcinoma, malignant lymphoma, and granular cell tumor of the stomach. (12080245)
2002
35
Dermatofibroma-like granular cell tumor. (11168752)
2001
36
Co-existing granular cell tumor and adenocarcinoma of the lung: a case report and review of the literature. (11403702)
2001
37
Granular cell tumor of the breast. (11079631)
2000
38
Multifocal granular cell tumor of the biliary tree: case report and review. (10650282)
2000
39
MR imaging findings in granular cell tumor of the neurohypophysis: a difficult preoperative diagnosis. (11305562)
2000
40
Synchronous glottic granular cell tumor and subglottic spindle cell carcinoma. (9738817)
1998
41
Symptomatic granular cell tumor of the pituitary gland: case report and review of the literature. (9442519)
1998
42
Granular cell tumor of the breast in a male. A case report. (9390147)
1997
43
Synchronous lingual granular cell tumor and squamous carcinoma. A case report and review of the literature. (9158404)
1997
44
Stump the experts. Case. Granular-cell tumor. (7582829)
1995
45
An unusual round cell tumor of the tibia with granular cells. (7726370)
1995
46
Cranial granular-cell tumor of the trigeminal nerve. Case report. (7931630)
1994
47
The coexistence of inflammatory fibroid polyp and granular cell tumor in the same gastric lesion. (7942750)
1994
48
Granular cell tumor of the pituitary stalk. Case report. (8189268)
1994
49
Malignant granular cell tumor. (1733419)
1992
50
Acoustic shadowing in benign granular cell tumor (myoblastoma) of the breast. (2822944)
1987

Genetic Variations for Granular Cell Tumor

Expression for genes affiliated with Granular Cell Tumor

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Granular Cell Tumor

Search GEO for disease gene expression data for Granular Cell Tumor.

Pathways for genes affiliated with Granular Cell Tumor

Sources:
4Cell Signaling Technology
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Pathways related to Granular Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8ENO2, NGFR, NTRK1, SYP, UCHL1, S100B

Compounds for genes affiliated with Granular Cell Tumor

Sources:
45Novoseek, 24HMDB, 29IUPHAR, 11DrugBank, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Granular Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1estrogen4510.8CALB2
2glycogen45 2411.7SYP
3glutamate4510.6NTRK1, NGFR
4orcein4510.5DES, S100B, VIM
5reticulin4510.5VIM, S100B, DES, SYP
6toluidine4510.4VIM, S100A1, DES, ENO2
7s 1004510.4S100B, SYP, ENO2, VIM, DES
8nmda45 2911.3SYP, VIM
9dopamine45 29 11 2413.3NTRK1, ENO2, CALB2, NGFR
10dbc-amp4510.3ENO2, NGFR, SYP, VIM, S100B
11creatinine4510.3SYP, CEACAM3, NTRK1, SERPINA1, MPZ
12biotin45 11 2412.2S100A1, MPZ, DES, INHA, VIM
13tellurium4510.2NGFR, MPZ
14bromodeoxyuridine4510.2DES, ENO2, VIM, MPZ, S100B
15formaldehyde45 2411.2DES, SYP, ENO2, VIM, S100B
16catecholamine4510.2SYP, ENO2, NGFR, NTRK1, S100B, VIM
17silver4510.2DES, S100A1, CALB2, SYP, ENO2
18l-amino acid4510.1S100B, ENO2, SYP
19acth4510.1SYP, INHA, SERPINA1, ENO2, CEACAM3, S100B
20acetylcholine45 50 29 11 2414.1NGFR, NTRK1, SYP, CALB2, ENO2, S100A1
21gaba4510.1NGFR, VIM, CALB2, ENO2, SYP, S100B
22serine4510.1UCHL1, S100B, DES, SYP, MPZ
23ethanol45 50 11 2413.1SERPINA1, CALB2, NGFR, SYP, DES, S100B
24ganglioside4510.1NGFR, ENO2, VIM, SYP, NTRK1, DES
25choline45 11 2412.1NTRK1, SYP, NGFR, ENO2, VIM, CALB2
2612-o-tetradecanoylphorbol 13-acetate4510.1NGFR, NTRK1, DES, UCHL1, VIM
27forskolin45 50 1112.0S100B, ENO2, INHA, NGFR, SYP, VIM
28methionine4510.0DES, S100B, VIM, MPZ, SERPINA1
29cyclic amp45 2411.0DES, SYP, NTRK1, NGFR, INHA, S100B
30mucicarmine4510.0CEACAM3, DES, S100A1, S100B, CALB2, VIM
31k252a4510.0VIM, NTRK1, NGFR
32b 7234510.0DES, VIM, CALB2, S100A1, CEACAM3, S100B
33estradiol45 11 2412.0DES, VIM, SYP, INHA, BOK, NTRK1
34iron45 2411.0VIM, S100B, ENO2, SERPINA1, DES, S100A1
35lactate4510.0MLANA, DES, S100B, ENO2, CEACAM3, VIM
36testosterone45 60 11 2412.9VIM, DES, S100B, CALB2, SYP, INHA
37aspartate459.9NTRK1, MPZ, S100B, VIM, CEACAM3, ENO2
38steroid459.9INHA, CALB2, CEACAM3, NGFR, SYP, DES
39cyanine459.8CALB2, CEACAM3
40thymidine45 2410.8S100B, BOK, CEACAM3, ENO2, NGFR, DES
41retinoic acid45 2410.7S100A1, SYP, NTRK1, NGFR, BOK, S100B
42vegf459.7SYP, ENO2, CEACAM3, NGFR, NTRK1, DES
43cysteine459.7NGFR, SYP, NTRK1, UCHL1, SERPINA1, S100A1
44lipid459.7ENO2, NGFR, NTRK1, SERPINA1, CD68, VIM
45oxygen45 2410.7ENO2, DES, NTRK1, NGFR, SERPINA1, CEACAM3
46nitric oxide45 11 2411.6S100B, S100A1, DES, SYP, NTRK1, NGFR
47hematoxylin459.5CALB2, S100B, MLANA, DES, SYP, NGFR
48paraffin459.2MLANA, S100A1, DES, SYP, ENO2, SERPINA1
49progesterone45 60 29 11 2413.1VIM, CALB2, S100A1, MPZ, DES, SYP
50tyrosine459.1NGFR, DES, INHA, SYP, SIGLEC7, CEACAM3

GO Terms for genes affiliated with Granular Cell Tumor

Sources:
16Gene Ontology
See all sources

Cellular components related to Granular Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:04302510.0INHA, NTRK1, UCHL1, S100B

Molecular functions related to Granular Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:04454810.2S100A1, S100B
2nerve growth factor bindingGO:0484069.9NGFR, NTRK1
3identical protein bindingGO:0428029.7SERPINA1, VIM, S100B, S100A1, DES, SYP

Products for genes affiliated with Granular Cell Tumor

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Granular Cell Tumor

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet