MCID: GRN010
MIFTS: 53

Granular Cell Tumor malady

Cancer diseases category

Summaries for Granular Cell Tumor

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Sources:
9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A carcinoma that derives from epithelial cells, with polygonal accumulation of secondary lysosomes in the cytoplasm.

MalaCards: Granular Cell Tumor, also known as granular cell adenocarcinoma, is related to perineurioma and adenocarcinoma. An important gene associated with Granular Cell Tumor is S100B (S100 calcium binding protein B), and among its related pathways are Striated Muscle Contraction and Aurora B signaling. The compounds eosin and toluidine have been mentioned in the context of this disorder. Affiliated tissues include breast, tongue and skin, and related mouse phenotype normal.

Wikipedia:66 Granular cell tumor is a tumor that can develop on any skin or mucosal surface, but occurs on the tongue... more...

Aliases & Classifications for Granular Cell Tumor

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

granular cell tumor 9 11 46 63
granular cell adenocarcinoma 9
neoplasm of granular cell 9
granular cell carcinoma 9
granular cell tumor nos 9


External Ids:

Disease Ontology9 DOID:2411, DOID:4903
NCIt41 C3474, C3681

Related Diseases for Granular Cell Tumor

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Granular Cell Tumor family:

Congenital Granular Cell Tumor

Diseases related to Granular Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 147)
idRelated DiseaseScoreTop Affiliating Genes
1perineurioma30.6VIM, S100B
2adenocarcinoma30.5SYP, VIM, SERPINA1, INHA, NTRK1
3gastrointestinal stromal tumor30.4S100B, VIM, DES
4spindle cell carcinoma30.2VIM, DES
5alveolar soft part sarcoma30.2VIM, DES
6breast cancer30.2SYP, VIM, NTRK1
7fibroma30.2DES, VIM
8paraganglioma30.2S100B, SYP
9leiomyosarcoma30.1DES, INHA, VIM, S100B
10sarcoma30.1S100B, VIM, DES, NTRK1
11melanoma29.9NTRK1, S100B, VIM, DES, SERPINA1, INHA
12myoblastoma10.7
13congenital granular cell tumor10.7
14gingivitis10.7
15esophagitis10.7
16epulis10.6
17congenital epulis10.6
18thyroiditis10.6
19laryngitis10.5
20vulvar granular cell tumor10.5
21skin granular cell tumor10.4
22malignant gastric granular cell tumor10.4
23noonan syndrome10.4
24hepatitis10.4
25malignant granular cell myoblastoma10.3
26breast granular cell tumor10.3
27cerebritis10.3
28cervicitis10.3
29mediastinitis10.3
30neurohypophysis granular cell tumor10.3
31malignant granular cell skin tumor10.3
32leopard syndrome10.3
33meningitis10.3
34pancreatitis10.3
35prostatitis10.3
36pituicytoma10.3
37syringoma10.1S100B
38fibrous meningioma10.1S100B
39acalculous cholecystitis10.1
40malignant granular cell esophageal tumor10.1
41cardiac granular cell neoplasm10.1
42mediastinal granular cell myoblastoma10.1
43acromegaly10.1
44appendicitis10.1
45granular cell leiomyosarcoma10.1
46churg-strauss syndrome10.1
47laryngotracheitis10.1
48eosinophilic esophagitis10.1
49vitiligo10.1
50bronchogenic carcinoma10.1

Graphical network of the top 20 diseases related to Granular Cell Tumor:



Diseases related to granular cell tumor

Symptoms for Granular Cell Tumor

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Drugs & Therapeutics for Granular Cell Tumor

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Granular Cell Tumor

Drug clinical trials:

Search ClinicalTrials for Granular Cell Tumor

Search NIH Clinical Center for Granular Cell Tumor

Search CenterWatch for Granular Cell Tumor

Genetic Tests for Granular Cell Tumor

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Anatomical Context for Granular Cell Tumor

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34MalaCards
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MalaCards organs/tissues related to Granular Cell Tumor:

34
Breast, Tongue, Skin, Colon, Thyroid, Trachea, Lung, Pituitary, Pancreas, Appendix, Prostate, Heart, Testes, Spinal cord, Uterus, Eye, Testis, Cervix, Bone

Animal Models for Granular Cell Tumor or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Granular Cell Tumor:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.2S100B, SYP, NTRK1, INHA

Publications for Granular Cell Tumor

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Sources:
53PubMed
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Articles related to Granular Cell Tumor:

(show top 50)    (show all 542)
idTitleAuthorsYear
1
Congenital granular cell tumor with uncommon clinical behavior. (23917999)
2013
2
Granular cell tumor of hand presenting as subcutaneous nodule mimicking dermal adnexal tumor: A diagnosis by cytology. (23439997)
2013
3
A case of granular cell tumor masquerading as a keratoacanthoma. (23627913)
2013
4
Malignant granular cell tumor of the breast: case report and literature review. (22467405)
2012
5
Unexpected granular cell tumor in abdominal wall: case report and literature review. (22495725)
2012
6
Oculomotor disturbances due to granular cell tumor. (21464781)
2012
7
Pathology quiz case 1. Diagnosis: multifocal granular cell tumor (GCT). (23069833)
2012
8
Granular cell tumor of the male breast: two case descriptions and brief review of the literature. (21876101)
2011
9
Malignant granular cell tumor of the thigh. (21815590)
2011
10
Granular cell tumor of the toe: a case report. (20862204)
2010
11
Diagnosis of malignant granular cell tumor metastatic to bone by fine needle aspiration cytology: a case report. (20391977)
2010
12
Isolated intra-oral granular cell tumor: report of two cases and review of the literature. (21053681)
2010
13
Granular cell tumor of ileocecal valve. (19452764)
2009
14
Magnetic resonance appearance of granular cell tumor of the breast. (19712822)
2009
15
Esophageal granular cell tumor treated by endoscopic mucosal resection. (19828958)
2009
16
Granular cell tumor of the common hepatic duct presenting as cholangiocarcinoma and acute acalculous cholecystitis. (19245149)
2008
17
Granular cell tumor of colon. (18386247)
2008
18
Granular-cell tumor: a rare variant of mammary tumor]. (18672708)
2008
19
Granular cell tumor of the tongue. (18982973)
2008
20
The unique simultaneous occurrence of a squamous cell carcinoma and a granular cell tumor of the tongue at the same site: a histological and immunohistochemical study. (19098584)
2008
21
Granular cell tumor of the urinary bladder with pseudoepitheliomatous hyperplasia and colocalization with adenocarcinoma. (17760758)
2007
22
Granular cell tumor of the esophagus and its endoscopic treatment. (17891699)
2007
23
Resection of a granular cell tumor of the larynx followed by medialization laryngoplasty with bipedicled sternohyoid muscle transposition. (17141103)
2006
24
A cerebral granular cell tumor in a cat. (16966466)
2006
25
A case of granular cell tumor of the bladder successfully managed with extraperitoneal laparoscopic surgery. (16834673)
2006
26
Granular cell tumor of the scrotum. (16150233)
2005
27
Granular cell tumor of the penis: clinicopathologic evaluation of 9 cases. (15791574)
2005
28
What is your diagnosis? Granular cell tumor. (15732430)
2005
29
Malignant granular cell tumor in larynx mimicking laryngeal carcinoma. (15239036)
2004
30
A rare case of a pulmonary granular cell tumor presenting as a coin lesion. (12691120)
2003
31
Coexistence of esophageal granular cell tumor and squamous cell carcinoma: a case report. (12060050)
2002
32
Endosonographic features of a granular cell tumor of the colon. (11758030)
2001
33
Diagnosis of malignant granular cell tumor by fine needle aspiration cytology:. (11726096)
2001
34
Granular cell tumor of intracranial meninges. (10774952)
2000
35
Malignant granular cell tumor of the vulva in a 17-year-old: Case report and literature review. (11240710)
2000
36
Granular cell tumor of the subcutis: CT and MRI findings. A report of three cases. (10197455)
1999
37
Granular cell tumor of the pituitary stalk. (9746304)
1998
38
Granular cell tumor of the extrahepatic biliary tract. (9798763)
1998
39
Granular cell tumor of the larynx in a six-year-old child: case report and review of the literature. (9745182)
1998
40
Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. (9669341)
1998
41
Congenital granular-cell tumor of the gingiva. (9799384)
1998
42
Synchronous glottic granular cell tumor and subglottic spindle cell carcinoma. (9738817)
1998
43
Orbital granular cell tumor developing in the inferior oblique muscle. (9439372)
1997
44
Epibulbar granular cell tumor. Report of a case and review of the literature. (9307640)
1997
45
Granular cell tumor of the sinus node. (8430653)
1993
46
A granular cell tumor of the buccal mucosa--a case report. (8007631)
1993
47
Granular cell tumor of the biliary tree. (1733352)
1992
48
Immunohistochemical study of congenital gingival granular cell tumor (congenital epulis). (1962817)
1990
49
Granular cell tumor (myoblastoma) of the eyebrow. (3035448)
1987
50
Granular cell tumor (myoblastoma) of the stomach. A case report with ultrastructural findings and review the literature. (4344382)
1972

Variations for Granular Cell Tumor

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Expression for genes affiliated with Granular Cell Tumor

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Granular Cell Tumor

Search GEO for disease gene expression data for Granular Cell Tumor.

Pathways for genes affiliated with Granular Cell Tumor

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 5Cell Signaling Technology
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Pathways related to Granular Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5VIM, DES
2
Show member pathways
Signaling by Aurora kinases39
Aurora C signaling39
9.5VIM, DES
38.7S100B, SYP, NTRK1

Compounds for genes affiliated with Granular Cell Tumor

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Sources:
46Novoseek, 25HMDB, 12DrugBank, 62Tocris Bioscience, 3BitterDB, 30IUPHAR, 52PharmGKB
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Compounds related to Granular Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1eosin469.9VIM, S100B
2toluidine469.6DES, VIM
3orcein469.6DES, S100B, VIM
4dbc-amp469.4VIM, SYP, S100B
5bromodeoxyuridine469.4DES, S100B, VIM
6biotin46 25 1211.3VIM, INHA, DES
7agarose469.3SERPINA1, S100B, INHA
8colchicine46 62 3 30 1213.2S100B, NTRK1, VIM
9gaba469.1VIM, S100B, SYP
10p003469.0SERPINA1, NTRK1, S100B
11methionine469.0VIM, S100B, SERPINA1, DES
12s 100469.0S100B, DES, VIM, SYP
13reticulin469.0DES, VIM, SYP, S100B
14mucicarmine469.0DES, SYP, S100B, VIM
15b 723469.0DES, SYP, VIM, S100B
16iron46 2510.0VIM, DES, SERPINA1, S100B
17forskolin46 52 1211.0INHA, VIM, S100B, SYP
18formaldehyde46 259.9DES, S100B, SYP, VIM
19heparin46 30 25 1211.9VIM, S100B, DES, SERPINA1
20imatinib46 52 1210.9S100B, NTRK1, DES
21acth468.9INHA, SERPINA1, SYP, S100B
22glycogen46 259.9S100B, SYP, VIM, DES
23ethanol46 52 25 1211.8SYP, DES, SERPINA1, S100B
24gnrh468.8INHA, NTRK1, VIM
25catecholamine468.7VIM, S100B, SYP, NTRK1
26lactate468.7DES, VIM, NTRK1, S100B
27choline46 25 1210.7S100B, NTRK1, SYP, VIM
28adenylate468.6NTRK1, S100B, DES, VIM
29hematoxylin468.5VIM, DES, INHA, SYP, S100B
30ganglioside468.5VIM, SYP, NTRK1, DES
31oligonucleotide468.4NTRK1, VIM, INHA, SERPINA1
32glutamate468.1VIM, NTRK1, SYP, S100B
33acetylcholine46 52 30 25 1212.1SYP, DES, VIM, S100B, NTRK1
34alanine468.1S100B, INHA, NTRK1, VIM
35vegf468.1DES, VIM, NTRK1, SYP, S100B
36retinoic acid46 259.1DES, SYP, VIM, S100B, NTRK1
37steroid468.1DES, S100B, SYP, INHA, NTRK1
38estradiol46 25 1210.1NTRK1, SYP, VIM, DES, INHA
39lipid468.0NTRK1, SYP, VIM, SERPINA1, S100B
40nitric oxide46 25 1210.0SYP, NTRK1, S100B, SERPINA1, DES
41h2o2468.0VIM, SYP, NTRK1, SERPINA1, DES
42cyclic amp46 258.7S100B, SYP, DES, NTRK1, VIM, INHA
43testosterone46 62 25 1210.7NTRK1, S100B, SYP, VIM, INHA, DES
44creatinine467.6SERPINA1, VIM, NTRK1, SYP, S100B, DES
45cysteine467.6S100B, SYP, NTRK1, DES, VIM, SERPINA1
46serine467.6S100B, DES, NTRK1, SERPINA1, VIM, SYP
47tyrosine467.5S100B, SYP, SERPINA1, INHA, DES, NTRK1
48paraffin467.2DES, SERPINA1, NTRK1, SYP, VIM, S100B
49progesterone46 30 62 25 1211.2VIM, SERPINA1, DES, INHA, SYP, NTRK1
50estrogen467.2VIM, S100B, SYP, NTRK1, SERPINA1, INHA

GO Terms for genes affiliated with Granular Cell Tumor

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Sources:
17Gene Ontology
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Cellular components related to Granular Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.5VIM, DES
2neuronal cell bodyGO:0430258.5S100B, NTRK1, INHA

Biological processes related to Granular Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.5VIM, DES
2regulation of neuronal synaptic plasticityGO:0481689.4S100B, SYP
3learning or memoryGO:0076119.0S100B, NTRK1

Molecular functions related to Granular Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.5VIM, DES
2identical protein bindingGO:0428027.9S100B, SYP, VIM, SERPINA1, DES
3protein bindingGO:0055157.1DES, INHA, SERPINA1, VIM, NTRK1, S100B

Products for genes affiliated with Granular Cell Tumor

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Sources for Granular Cell Tumor

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet