MCID: GRN010
MIFTS: 45

Granular Cell Tumor malady

Cancer diseases category

Aliases & Classifications for Granular Cell Tumor

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 33MeSH, 38NCIt
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Granular Cell Tumor, Aliases & Descriptions:

Name: Granular Cell Tumor 9 11 43 60
Granular Cell Adenocarcinoma 9
Neoplasm of Granular Cell 9
 
Carcinoma, Granular Cell 60
Granular Cell Carcinoma 9
Granular Cell Tumor Nos 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology9 DOID:2411, DOID:4903
NCIt38 C3474, C3681

Summaries for Granular Cell Tumor

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Disease Ontology:9 A carcinoma that derives from epithelial cells, with polygonal accumulation of secondary lysosomes in the cytoplasm.

MalaCards based summary: Granular Cell Tumor, also known as granular cell adenocarcinoma, is related to perineurioma and alveolar soft-part sarcoma. An important gene associated with Granular Cell Tumor is S100B (S100 calcium binding protein B), and among its related pathways are Striated Muscle Contraction and Aurora B signaling. The compounds eosin and toluidine have been mentioned in the context of this disorder. Affiliated tissues include breast, tongue and skin, and related mouse phenotype normal.

Wikipedia:63 Granular cell tumor is a tumor that can develop on any skin or mucosal surface, but occurs on the tongue... more...

Related Diseases for Granular Cell Tumor

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Diseases in the Granular Cell Tumor family:

Congenital Granular Cell Tumor

Diseases related to Granular Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 142)
idRelated DiseaseScoreTop Affiliating Genes
1perineurioma31.1S100B, VIM
2alveolar soft-part sarcoma30.8VIM, DES
3gastrointestinal stromal tumor30.6S100B, VIM, DES
4spindle cell carcinoma30.6DES, VIM
5fibroma30.5VIM, DES
6paraganglioma30.4SYP, S100B
7leiomyosarcoma30.1S100B, VIM, INHA, DES
8sarcoma30.0DES, VIM, NTRK1, S100B
9adenocarcinoma30.0INHA, SERPINA1, VIM, NTRK1, SYP
10breast cancer30.0SYP, NTRK1, VIM
11melanoma29.2DES, INHA, SERPINA1, VIM, NTRK1, S100B
12congenital granular cell tumor10.8
13myoblastoma10.8
14esophagitis10.7
15gingivitis10.7
16epulis10.6
17thyroiditis10.6
18congenital epulis10.6
19laryngitis10.5
20syringoma10.5S100B
21vulvar granular cell tumor10.5
22fibrous meningioma10.5S100B
23skin granular cell tumor10.5
24malignant gastric granular cell tumor10.5
25mediastinitis10.5
26adenomatoid tumor10.5VIM
27infantile myofibromatosis10.4DES
28hepatitis10.4
29breast granular cell tumor10.4
30melanotic neuroectodermal tumor10.4SYP
31malignant granular cell myoblastoma10.4
32neurohypophysis granular cell tumor10.4
33cerebritis10.4
34cervicitis10.4
35dysembryoplastic neuroepithelial tumor10.3SYP
36myoepithelioma10.3VIM, S100B
37malignant granular cell esophageal tumor10.3
38cardiac granular cell neoplasm10.3
39mediastinal granular cell myoblastoma10.3
40malignant granular cell skin tumor10.3
41leopard syndrome10.3
42meningitis10.3
43pancreatitis10.3
44prostatitis10.3
45pituicytoma10.3
46malignant peripheral nerve sheath tumor10.3VIM, S100B
47salivary gland adenoid cystic carcinoma10.3S100B, VIM
48epithelioid leiomyosarcoma10.3DES, VIM
49cutaneous fibrous histiocytoma10.3S100B, DES
50mesenchymal chondrosarcoma10.3VIM, DES

Graphical network of the top 20 diseases related to Granular Cell Tumor:



Diseases related to granular cell tumor

Symptoms for Granular Cell Tumor

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Drugs & Therapeutics for Granular Cell Tumor

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Drug clinical trials:

Search ClinicalTrials for Granular Cell Tumor

Search NIH Clinical Center for Granular Cell Tumor

Genetic Tests for Granular Cell Tumor

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Anatomical Context for Granular Cell Tumor

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MalaCards organs/tissues related to Granular Cell Tumor:

31
Breast, Tongue, Skin, Colon, Thyroid, Lung, Trachea, Pituitary, Pancreas, Spinal cord, Heart, Prostate, Testes, Appendix, Eye, Bone, Uterus, Testis, Cervix

Animal Models for Granular Cell Tumor or affiliated genes

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MGI Mouse Phenotypes related to Granular Cell Tumor:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.2S100B, SYP, NTRK1, INHA

Publications for Granular Cell Tumor

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Articles related to Granular Cell Tumor:

(show top 50)    (show all 587)
idTitleAuthorsYear
1
Granular cell tumor presenting as a large leg mass. (25692157)
2014
2
A case of primitive non-neural granular cell tumor presenting as a single painless bleeding nodule. (24855577)
2014
3
Congenital granular cell tumor with uncommon clinical behavior. (23917999)
2013
4
Granular cell tumor of hand presenting as subcutaneous nodule mimicking dermal adnexal tumor: A diagnosis by cytology. (23439997)
2013
5
A case of granular cell tumor masquerading as a keratoacanthoma. (23627913)
2013
6
Malignant granular cell tumor of the breast: case report and literature review. (22467405)
2012
7
Unexpected granular cell tumor in abdominal wall: case report and literature review. (22495725)
2012
8
Oculomotor disturbances due to granular cell tumor. (21464781)
2012
9
Granular cell tumor of the male breast: two case descriptions and brief review of the literature. (21876101)
2011
10
Cecal granular cell tumor. (21407113)
2011
11
Malignant granular cell tumor of the thigh. (21815590)
2011
12
Granular cell tumor of the toe: a case report. (20862204)
2010
13
Diagnosis of malignant granular cell tumor metastatic to bone by fine needle aspiration cytology: a case report. (20391977)
2010
14
Isolated intra-oral granular cell tumor: report of two cases and review of the literature. (21053681)
2010
15
Granular cell tumor of ileocecal valve. (19452764)
2009
16
Magnetic resonance appearance of granular cell tumor of the breast. (19712822)
2009
17
Esophageal granular cell tumor treated by endoscopic mucosal resection. (19828958)
2009
18
Granular cell tumor of the common hepatic duct presenting as cholangiocarcinoma and acute acalculous cholecystitis. (19245149)
2008
19
Granular cell tumor of colon. (18386247)
2008
20
Granular-cell tumor: a rare variant of mammary tumor]. (18672708)
2008
21
Granular cell tumor of the tongue. (18982973)
2008
22
The unique simultaneous occurrence of a squamous cell carcinoma and a granular cell tumor of the tongue at the same site: a histological and immunohistochemical study. (19098584)
2008
23
Granular cell tumor of the urinary bladder with pseudoepitheliomatous hyperplasia and colocalization with adenocarcinoma. (17760758)
2007
24
Granular cell tumor of the esophagus and its endoscopic treatment. (17891699)
2007
25
Resection of a granular cell tumor of the larynx followed by medialization laryngoplasty with bipedicled sternohyoid muscle transposition. (17141103)
2006
26
A cerebral granular cell tumor in a cat. (16966466)
2006
27
A case of granular cell tumor of the bladder successfully managed with extraperitoneal laparoscopic surgery. (16834673)
2006
28
Granular cell tumor of the scrotum. (16150233)
2005
29
Granular cell tumor of the breast. (16297125)
2005
30
Granular cell tumor of the penis: clinicopathologic evaluation of 9 cases. (15791574)
2005
31
Malignant granular cell tumor in larynx mimicking laryngeal carcinoma. (15239036)
2004
32
A rare case of a pulmonary granular cell tumor presenting as a coin lesion. (12691120)
2003
33
Coexistence of esophageal granular cell tumor and squamous cell carcinoma: a case report. (12060050)
2002
34
Endosonographic features of a granular cell tumor of the colon. (11758030)
2001
35
Granular cell tumor of intracranial meninges. (10774952)
2000
36
Malignant granular cell tumor of the vulva in a 17-year-old: Case report and literature review. (11240710)
2000
37
Granular cell tumor of the subcutis: CT and MRI findings. A report of three cases. (10197455)
1999
38
Granular cell tumor of the pituitary stalk. (9746304)
1998
39
Granular cell tumor of the extrahepatic biliary tract. (9798763)
1998
40
Granular cell tumor of the larynx in a six-year-old child: case report and review of the literature. (9745182)
1998
41
Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. (9669341)
1998
42
Congenital granular-cell tumor of the gingiva. (9799384)
1998
43
Orbital granular cell tumor developing in the inferior oblique muscle. (9439372)
1997
44
Epibulbar granular cell tumor. Report of a case and review of the literature. (9307640)
1997
45
Granular cell tumor of the sinus node. (8430653)
1993
46
A granular cell tumor of the buccal mucosa--a case report. (8007631)
1993
47
Granular cell tumor of the biliary tree. (1733352)
1992
48
Immunohistochemical study of congenital gingival granular cell tumor (congenital epulis). (1962817)
1990
49
Granular cell tumor (myoblastoma) of the eyebrow. (3035448)
1987
50
Granular cell tumor (myoblastoma) of the stomach. A case report with ultrastructural findings and review the literature. (4344382)
1972

Variations for Granular Cell Tumor

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Expression for genes affiliated with Granular Cell Tumor

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Search GEO for disease gene expression data for Granular Cell Tumor.

Pathways for genes affiliated with Granular Cell Tumor

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Pathways related to Granular Cell Tumor according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5VIM, DES
2
Show member pathways
Signaling by Aurora kinases36
Aurora C signaling36
9.5VIM, DES
38.7S100B, SYP, NTRK1

Compounds for genes affiliated with Granular Cell Tumor

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Compounds related to Granular Cell Tumor according to GeneCards Suite gene sharing:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1eosin439.9VIM, S100B
2toluidine439.6DES, VIM
3orcein439.6DES, S100B, VIM
4dbc-amp439.4VIM, SYP, S100B
5bromodeoxyuridine439.4DES, S100B, VIM
6biotin43 24 1211.3VIM, INHA, DES
7agarose439.3SERPINA1, S100B, INHA
8colchicine43 59 2 28 1213.2S100B, NTRK1, VIM
9gaba439.1VIM, S100B, SYP
10p003439.0SERPINA1, NTRK1, S100B
11methionine439.0VIM, S100B, SERPINA1, DES
12s 100439.0S100B, DES, VIM, SYP
13reticulin439.0DES, VIM, SYP, S100B
14mucicarmine439.0DES, SYP, S100B, VIM
15b 723439.0DES, SYP, VIM, S100B
16iron43 2410.0VIM, DES, SERPINA1, S100B
17forskolin43 49 1211.0INHA, VIM, S100B, SYP
18formaldehyde43 249.9DES, S100B, SYP, VIM
19heparin43 28 24 1211.9VIM, S100B, DES, SERPINA1
20imatinib43 49 1210.9S100B, NTRK1, DES
21acth438.9INHA, SERPINA1, SYP, S100B
22glycogen43 249.9S100B, SYP, VIM, DES
23ethanol43 49 24 1211.8SYP, DES, SERPINA1, S100B
24gnrh438.8INHA, NTRK1, VIM
25catecholamine438.7VIM, S100B, SYP, NTRK1
26lactate438.7DES, VIM, NTRK1, S100B
27choline43 24 1210.7S100B, NTRK1, SYP, VIM
28adenylate438.6NTRK1, S100B, DES, VIM
29hematoxylin438.5VIM, DES, INHA, SYP, S100B
30ganglioside438.5VIM, SYP, NTRK1, DES
31oligonucleotide438.4NTRK1, VIM, INHA, SERPINA1
32glutamate438.1VIM, NTRK1, SYP, S100B
33acetylcholine43 49 28 24 1212.1SYP, DES, VIM, S100B, NTRK1
34alanine438.1S100B, INHA, NTRK1, VIM
35vegf438.1DES, VIM, NTRK1, SYP, S100B
36retinoic acid43 249.1DES, SYP, VIM, S100B, NTRK1
37steroid438.1DES, S100B, SYP, INHA, NTRK1
38estradiol43 24 1210.1NTRK1, SYP, VIM, DES, INHA
39lipid438.0NTRK1, SYP, VIM, SERPINA1, S100B
40nitric oxide43 24 1210.0SYP, NTRK1, S100B, SERPINA1, DES
41h2o2438.0VIM, SYP, NTRK1, SERPINA1, DES
42cyclic amp43 248.7S100B, SYP, DES, NTRK1, VIM, INHA
43testosterone43 59 24 1210.7NTRK1, S100B, SYP, VIM, INHA, DES
44creatinine437.6SERPINA1, VIM, NTRK1, SYP, S100B, DES
45cysteine437.6S100B, SYP, NTRK1, DES, VIM, SERPINA1
46serine437.6S100B, DES, NTRK1, SERPINA1, VIM, SYP
47tyrosine437.5S100B, SYP, SERPINA1, INHA, DES, NTRK1
48paraffin437.2DES, SERPINA1, NTRK1, SYP, VIM, S100B
49progesterone43 28 59 24 1211.2VIM, SERPINA1, DES, INHA, SYP, NTRK1
50estrogen437.2VIM, S100B, SYP, NTRK1, SERPINA1, INHA

GO Terms for genes affiliated with Granular Cell Tumor

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Cellular components related to Granular Cell Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.5VIM, DES
2neuronal cell bodyGO:00430258.5S100B, NTRK1, INHA

Biological processes related to Granular Cell Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:00300499.5VIM, DES
2regulation of neuronal synaptic plasticityGO:00481689.4S100B, SYP
3learning or memoryGO:00076119.0S100B, NTRK1

Molecular functions related to Granular Cell Tumor according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:00052009.5VIM, DES
2identical protein bindingGO:00428027.9S100B, SYP, VIM, SERPINA1, DES
3protein bindingGO:00055157.1DES, INHA, SERPINA1, VIM, NTRK1, S100B

Products for genes affiliated with Granular Cell Tumor

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Sources for Granular Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet