MCID: GRN010
MIFTS: 54

Granular Cell Tumor malady

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Summaries for Granular Cell Tumor

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Disease Ontology:8 A carcinoma that derives from epithelial cells, with polygonal accumulation of secondary lysosomes in the cytoplasm.

MalaCards based summary: Granular Cell Tumor, also known as neoplasm of granular cell, is related to perineurioma and alveolar soft part sarcoma. An important gene associated with Granular Cell Tumor is S100B (S100 calcium binding protein B), and among its related pathways are Striated Muscle Contraction and Aurora B signaling. The compounds eosin and toluidine have been mentioned in the context of this disorder. Affiliated tissues include breast, tongue and skin, and related mouse phenotype normal.

Wikipedia:65 Granular cell tumor is a tumor that can develop on any skin or mucosal surface, but occurs on the tongue... more...

Aliases & Classifications for Granular Cell Tumor

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 39NCIt, 34MeSH, 57SNOMED-CT
See all sources

Granular Cell Tumor, Aliases & Descriptions:

Name: Granular Cell Tumor 8 10 44 62
Neoplasm of Granular Cell 8 62
Adenocarcinoma, Granular Cell 62
Granular Cell Adenocarcinoma 8
 
Carcinoma, Granular Cell 62
Granular Cell Tumor Nos 8
Granular Cell Carcinoma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


External Ids:

Disease Ontology8 DOID:2411, DOID:4903
NCIt39 C3474, C3681

Related Diseases for Granular Cell Tumor

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Diseases in the Granular Cell Tumor family:

Congenital Granular Cell Tumor

Diseases related to Granular Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1perineurioma31.0VIM, S100B
2alveolar soft part sarcoma30.8VIM, DES
3gastrointestinal stromal tumor30.6S100B, VIM, DES
4spindle cell carcinoma30.6VIM, DES
5fibroma30.5DES, VIM
6paraganglioma30.4S100B, SYP
7leiomyosarcoma30.1DES, INHA, VIM, S100B
8sarcoma30.0S100B, VIM, DES, NTRK1
9breast cancer30.0SYP, VIM, NTRK1
10adenocarcinoma29.9SYP, VIM, SERPINA1, INHA, NTRK1
11melanoma29.2NTRK1, S100B, VIM, DES, SERPINA1, INHA
12myoblastoma10.8
13congenital granular cell tumor10.7
14esophagitis10.7
15gingivitis10.7
16epulis10.6
17thyroiditis10.6
18congenital epulis10.6
19laryngitis10.5
20syringoma10.5S100B
21fibrous meningioma10.5S100B
22vulvar granular cell tumor10.5
23malignant gastric granular cell tumor10.5
24mediastinitis10.5
25adenomatoid tumor10.5VIM
26infantile myofibromatosis10.4DES
27hepatitis10.4
28skin granular cell tumor10.4
29melanotic neuroectodermal tumor10.4SYP
30malignant granular cell skin tumor10.4
31malignant granular cell myoblastoma10.4
32breast granular cell tumor10.4
33noonan syndrome10.4
34cerebritis10.4
35cervicitis10.4
36dysembryoplastic neuroepithelial tumor10.4SYP
37myoepithelioma10.3S100B, VIM
38malignant peripheral nerve sheath tumor10.3VIM, S100B
39leopard syndrome10.3
40malignant granular cell esophageal tumor10.3
41cardiac granular cell neoplasm10.3
42neurohypophysis granular cell tumor10.3
43mediastinal granular cell myoblastoma10.3
44meningitis10.3
45pancreatitis10.3
46prostatitis10.3
47pituicytoma10.3
48salivary gland adenoid cystic carcinoma10.3S100B, VIM
49cutaneous fibrous histiocytoma10.3DES, S100B
50epithelioid leiomyosarcoma10.3VIM, DES

Graphical network of the top 20 diseases related to Granular Cell Tumor:



Diseases related to granular cell tumor

Symptoms for Granular Cell Tumor

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Drugs & Therapeutics for Granular Cell Tumor

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Drug clinical trials:

Search ClinicalTrials for Granular Cell Tumor

Search NIH Clinical Center for Granular Cell Tumor

Genetic Tests for Granular Cell Tumor

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Anatomical Context for Granular Cell Tumor

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MalaCards organs/tissues related to Granular Cell Tumor:

32
Breast, Tongue, Skin, Colon, Thyroid, Lung, Trachea, Pituitary, Pancreas, Spinal cord, Heart, Prostate, Testes, Appendix, Eye, Bone, Uterus, Testis, Cervix

Animal Models for Granular Cell Tumor or affiliated genes

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MGI Mouse Phenotypes related to Granular Cell Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00028738.2S100B, SYP, NTRK1, INHA

Publications for Granular Cell Tumor

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Articles related to Granular Cell Tumor:

(show top 50)    (show all 562)
idTitleAuthorsYear
1
A case of primitive non-neural granular cell tumor presenting as a single painless bleeding nodule. (24855577)
2014
2
Congenital granular cell tumor with uncommon clinical behavior. (23917999)
2013
3
Granular cell tumor of hand presenting as subcutaneous nodule mimicking dermal adnexal tumor: A diagnosis by cytology. (23439997)
2013
4
A case of granular cell tumor masquerading as a keratoacanthoma. (23627913)
2013
5
Malignant granular cell tumor of the breast: case report and literature review. (22467405)
2012
6
Unexpected granular cell tumor in abdominal wall: case report and literature review. (22495725)
2012
7
Oculomotor disturbances due to granular cell tumor. (21464781)
2012
8
Granular cell tumor of the male breast: two case descriptions and brief review of the literature. (21876101)
2011
9
Cecal granular cell tumor. (21407113)
2011
10
Malignant granular cell tumor of the thigh. (21815590)
2011
11
Granular cell tumor of the toe: a case report. (20862204)
2010
12
Diagnosis of malignant granular cell tumor metastatic to bone by fine needle aspiration cytology: a case report. (20391977)
2010
13
Isolated intra-oral granular cell tumor: report of two cases and review of the literature. (21053681)
2010
14
Granular cell tumor of ileocecal valve. (19452764)
2009
15
Magnetic resonance appearance of granular cell tumor of the breast. (19712822)
2009
16
Esophageal granular cell tumor treated by endoscopic mucosal resection. (19828958)
2009
17
Granular cell tumor of the common hepatic duct presenting as cholangiocarcinoma and acute acalculous cholecystitis. (19245149)
2008
18
Granular cell tumor of colon. (18386247)
2008
19
Granular-cell tumor: a rare variant of mammary tumor]. (18672708)
2008
20
Granular cell tumor of the tongue. (18982973)
2008
21
The unique simultaneous occurrence of a squamous cell carcinoma and a granular cell tumor of the tongue at the same site: a histological and immunohistochemical study. (19098584)
2008
22
Granular cell tumor of the urinary bladder with pseudoepitheliomatous hyperplasia and colocalization with adenocarcinoma. (17760758)
2007
23
Granular cell tumor of the esophagus and its endoscopic treatment. (17891699)
2007
24
Resection of a granular cell tumor of the larynx followed by medialization laryngoplasty with bipedicled sternohyoid muscle transposition. (17141103)
2006
25
A cerebral granular cell tumor in a cat. (16966466)
2006
26
A case of granular cell tumor of the bladder successfully managed with extraperitoneal laparoscopic surgery. (16834673)
2006
27
Granular cell tumor of the scrotum. (16150233)
2005
28
Granular cell tumor of the breast. (16297125)
2005
29
Granular cell tumor of the penis: clinicopathologic evaluation of 9 cases. (15791574)
2005
30
Malignant granular cell tumor in larynx mimicking laryngeal carcinoma. (15239036)
2004
31
A rare case of a pulmonary granular cell tumor presenting as a coin lesion. (12691120)
2003
32
Coexistence of esophageal granular cell tumor and squamous cell carcinoma: a case report. (12060050)
2002
33
Endosonographic features of a granular cell tumor of the colon. (11758030)
2001
34
Granular cell tumor of intracranial meninges. (10774952)
2000
35
Malignant granular cell tumor of the vulva in a 17-year-old: Case report and literature review. (11240710)
2000
36
Granular cell tumor of the subcutis: CT and MRI findings. A report of three cases. (10197455)
1999
37
Granular cell tumor of the pituitary stalk. (9746304)
1998
38
Granular cell tumor of the extrahepatic biliary tract. (9798763)
1998
39
Granular cell tumor of the larynx in a six-year-old child: case report and review of the literature. (9745182)
1998
40
Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. (9669341)
1998
41
Congenital granular-cell tumor of the gingiva. (9799384)
1998
42
Synchronous glottic granular cell tumor and subglottic spindle cell carcinoma. (9738817)
1998
43
Orbital granular cell tumor developing in the inferior oblique muscle. (9439372)
1997
44
Epibulbar granular cell tumor. Report of a case and review of the literature. (9307640)
1997
45
Granular cell tumor of the sinus node. (8430653)
1993
46
A granular cell tumor of the buccal mucosa--a case report. (8007631)
1993
47
Granular cell tumor of the biliary tree. (1733352)
1992
48
Immunohistochemical study of congenital gingival granular cell tumor (congenital epulis). (1962817)
1990
49
Granular cell tumor (myoblastoma) of the eyebrow. (3035448)
1987
50
Granular cell tumor (myoblastoma) of the stomach. A case report with ultrastructural findings and review the literature. (4344382)
1972

Variations for Granular Cell Tumor

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Expression for genes affiliated with Granular Cell Tumor

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Expression patterns in normal tissues for genes affiliated with Granular Cell Tumor

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Pathways for genes affiliated with Granular Cell Tumor

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Pathways related to Granular Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5VIM, DES
2
Show member pathways
Signaling by Aurora kinases37
Aurora C signaling37
9.5VIM, DES
38.7S100B, SYP, NTRK1

Compounds for genes affiliated with Granular Cell Tumor

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Compounds related to Granular Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1eosin449.9VIM, S100B
2toluidine449.6DES, VIM
3orcein449.6DES, S100B, VIM
4dbc-amp449.4VIM, SYP, S100B
5bromodeoxyuridine449.4DES, S100B, VIM
6biotin44 24 1111.3VIM, INHA, DES
7agarose449.3SERPINA1, S100B, INHA
8colchicine44 61 2 28 1113.2S100B, NTRK1, VIM
9gaba449.1VIM, S100B, SYP
10p003449.0SERPINA1, NTRK1, S100B
11methionine449.0VIM, S100B, SERPINA1, DES
12s 100449.0S100B, DES, VIM, SYP
13reticulin449.0DES, VIM, SYP, S100B
14mucicarmine449.0DES, SYP, S100B, VIM
15b 723449.0DES, SYP, VIM, S100B
16iron44 2410.0VIM, DES, SERPINA1, S100B
17forskolin44 50 1111.0INHA, VIM, S100B, SYP
18formaldehyde44 249.9DES, S100B, SYP, VIM
19heparin44 28 24 1111.9VIM, S100B, DES, SERPINA1
20imatinib44 50 1110.9S100B, NTRK1, DES
21acth448.9INHA, SERPINA1, SYP, S100B
22glycogen44 249.9S100B, SYP, VIM, DES
23ethanol44 50 24 1111.8SYP, DES, SERPINA1, S100B
24gnrh448.8INHA, NTRK1, VIM
25catecholamine448.7VIM, S100B, SYP, NTRK1
26lactate448.7DES, VIM, NTRK1, S100B
27choline44 24 1110.7S100B, NTRK1, SYP, VIM
28adenylate448.6NTRK1, S100B, DES, VIM
29hematoxylin448.5VIM, DES, INHA, SYP, S100B
30ganglioside448.5VIM, SYP, NTRK1, DES
31oligonucleotide448.4NTRK1, VIM, INHA, SERPINA1
32glutamate448.1VIM, NTRK1, SYP, S100B
33acetylcholine44 50 28 24 1112.1SYP, DES, VIM, S100B, NTRK1
34alanine448.1S100B, INHA, NTRK1, VIM
35vegf448.1DES, VIM, NTRK1, SYP, S100B
36retinoic acid44 249.1DES, SYP, VIM, S100B, NTRK1
37steroid448.1DES, S100B, SYP, INHA, NTRK1
38estradiol44 24 1110.1NTRK1, SYP, VIM, DES, INHA
39lipid448.0NTRK1, SYP, VIM, SERPINA1, S100B
40nitric oxide44 24 1110.0SYP, NTRK1, S100B, SERPINA1, DES
41h2o2448.0VIM, SYP, NTRK1, SERPINA1, DES
42cyclic amp44 248.7S100B, SYP, DES, NTRK1, VIM, INHA
43testosterone44 61 24 1110.7NTRK1, S100B, SYP, VIM, INHA, DES
44creatinine447.6SERPINA1, VIM, NTRK1, SYP, S100B, DES
45cysteine447.6S100B, SYP, NTRK1, DES, VIM, SERPINA1
46serine447.6S100B, DES, NTRK1, SERPINA1, VIM, SYP
47tyrosine447.5S100B, SYP, SERPINA1, INHA, DES, NTRK1
48paraffin447.2DES, SERPINA1, NTRK1, SYP, VIM, S100B
49progesterone44 28 61 24 1111.2VIM, SERPINA1, DES, INHA, SYP, NTRK1
50estrogen447.2VIM, S100B, SYP, NTRK1, SERPINA1, INHA

GO Terms for genes affiliated with Granular Cell Tumor

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Cellular components related to Granular Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.5VIM, DES
2neuronal cell bodyGO:0430258.5S100B, NTRK1, INHA

Biological processes related to Granular Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1muscle filament slidingGO:0300499.5VIM, DES
2regulation of neuronal synaptic plasticityGO:0481689.4S100B, SYP
3learning or memoryGO:0076119.0S100B, NTRK1

Molecular functions related to Granular Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.5VIM, DES
2identical protein bindingGO:0428027.9S100B, SYP, VIM, SERPINA1, DES
3protein bindingGO:0055157.1DES, INHA, SERPINA1, VIM, NTRK1, S100B

Products for genes affiliated with Granular Cell Tumor

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Sources for Granular Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet