MCID: GRN010
MIFTS: 53

Granular Cell Tumor malady

Cancer diseases category

Summaries for Granular Cell Tumor

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A carcinoma that derives from epithelial cells, with polygonal accumulation of secondary lysosomes in the cytoplasm.

MalaCards: Granular Cell Tumor, also known as granular cell adenocarcinoma, is related to epulis and adenocarcinoma. An important gene associated with Granular Cell Tumor is S100B (S100 calcium binding protein B), and among its related pathways is Neuroscience. The compounds estrogen and glycogen have been mentioned in the context of this disorder. Affiliated tissues include breast, tongue and skin, and related mouse phenotype behavior/neurological.

Wikipedia:63 Granular cell tumor is a tumor that can develop on any skin or mucosal surface, but occurs on the tongue... more...

Aliases & Classifications for Granular Cell Tumor

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases


Aliases & Descriptions:

granular cell tumor 8 10 44 60
granular cell adenocarcinoma 8
neoplasm of granular cell 8
granular cell carcinoma 8
granular cell tumor nos 8


External Ids:

Disease Ontology8 DOID:2411, DOID:4903
NCIt39 C3474, C3681

Related Diseases for Granular Cell Tumor

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Granular Cell Tumor family:

Congenital Granular Cell Tumor

Diseases related to Granular Cell Tumor via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 205)
idRelated DiseaseScoreTop Affiliating Genes
1epulis30.8ENO2
2adenocarcinoma30.6VIM, CALB2, SYP, NTRK1, NGFR, INHA
3squamous cell carcinoma30.6VIM, CALB2, S100A1, SYP, NTRK1, NGFR
4hepatitis30.5SERPINA1
5giant cell tumor30.5VIM, S100B, DES, CEACAM3
6perineurioma30.4S100B, VIM
7pancreatitis30.3SERPINA1
8gastrointestinal stromal tumor30.3VIM, S100B, S100A1, DES, ENO2
9breast cancer30.3VIM, S100A1, SYP, NTRK1, NGFR, CEACAM3
10hemangioma30.1CD68
11lipoma30.1DES, S100A1
12alveolar soft part sarcoma30.1VIM, DES, ENO2
13spindle cell carcinoma30.1DES, VIM
14paraganglioma30.1S100B, S100A1, SYP, ENO2
15prostate cancer30.1NTRK1, INHA, ENO2, CEACAM3
16leiomyosarcoma30.1DES, MLANA, S100A1, S100B, CALB2, VIM
17sarcoma30.1ENO2, NTRK1, DES, MLANA, S100A1, S100B
18melanoma30.1ENO2, CEACAM3, SERPINA1, INHA, CD68, VIM
19breast granular cell tumor10.9
20congenital granular cell tumor10.8
21myoblastoma10.7
22gingivitis10.7
23neurohypophysis granular cell tumor10.6
24esophagitis10.6
25congenital epulis10.6
26thyroiditis10.5
27vulvar granular cell tumor10.5
28skin granular cell tumor10.5
29laryngitis10.5
30noonan syndrome10.4
31malignant gastric granular cell tumor10.4
32malignant granular cell myoblastoma10.4
33cerebritis10.3
34hepatitis a10.3
35cervicitis10.3
36mediastinitis10.3
37leopard syndrome10.2
38malignant granular cell skin tumor10.2
39meningitis10.2
40prostatitis10.2
41acalculous cholecystitis10.1
42eosinophilic esophagitis10.1
43mediastinal granular cell myoblastoma10.1
44cardiac granular cell neoplasm10.1
45malignant granular cell esophageal tumor10.1
46acromegaly10.1
47appendicitis10.1
48lipoma of colon10.1
49pulmonary coin lesion10.1
50granular cell leiomyosarcoma10.1

Graphical network of the top 20 diseases related to Granular Cell Tumor:



Diseases related to granular cell tumor

Clinical Features for Granular Cell Tumor

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Drugs & Therapeutics for Granular Cell Tumor

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Granular Cell Tumor

Drug clinical trials:

Search ClinicalTrials for Granular Cell Tumor

Search NIH Clinical Center for Granular Cell Tumor

Search CenterWatch for Granular Cell Tumor

Genetic Tests for Granular Cell Tumor

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Anatomical Context for Granular Cell Tumor

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32MalaCards
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MalaCards organs/tissues related to Granular Cell Tumor:

32
Breast, Tongue, Skin, Colon, Thyroid, Trachea, Pituitary, Lung, Pancreas, Appendix, Heart, Prostate, Spinal cord, Testes, Bone, Cervix, Testis, Uterus, Kidney, Eye

Animal Models for Granular Cell Tumor or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Granular Cell Tumor:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053869.3ENO2, CALB2, S100B, S100A1, UCHL1, MPZ

Publications for Granular Cell Tumor

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50PubMed
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Articles related to Granular Cell Tumor:

(show top 50)    (show all 562)
idTitleAuthorsYear
1
Clinical and histopathological features of granular cell tumor. (22804489)
2013
2
Granular Cell Tumor of the Testicular Tunica Albuginea: A Case Report. (23455175)
2013
3
Giant malignant granular cell tumor (GCT) of the posterior mediastinum. (23857402)
2013
4
Granular cell tumor of the appendix: a new case and review of the literature. (24349953)
2013
5
Oculomotor disturbances due to granular cell tumor. (21464781)
2012
6
A malignant granular cell tumor excised with mohs micrographic surgery. (22606454)
2012
7
Granular cell tumor. (21679541)
2011
8
Granular cell tumor of the toe: a case report. (20862204)
2010
9
Coexistence of granular cell tumor and schwannoma in a patient with vitiligo. (20375935)
2010
10
Fine-needle aspiration biopsy of granular cell tumor of the tongue: a technique for the aspiration of oral lesions. (19526573)
2009
11
Central granular cell odontogenic tumor: a histopathologic and immunohistochemical study. (19917479)
2009
12
An unusually large granular cell tumor of the pharynx: a case report and literature review. (19079624)
2009
13
Granular-cell tumor: a rare variant of mammary tumor]. (18672708)
2008
14
Granular cell tumor of the tongue. (18982973)
2008
15
Granular cell tumor of the esophagus: three case reports and review of the literature. (19115155)
2008
16
Granular cell tumor of the glans penis in a 9-year-old boy. (18342206)
2008
17
Multifocal granular cell tumor presenting as an esophageal stricture. (19340612)
2008
18
Granular cell tumor of the scrotum in a child with Noonan syndrome. (18577039)
2008
19
Granular cell tumor of the hypopharynx. (18359369)
2008
20
An unusual complication after an insect bite? Diagnostic procedures in a case of granular cell tumor]. (16555043)
2007
21
Granular cell tumor in colonic polyp found on screening colonoscopy. (17428738)
2007
22
Recurrent granular cell tumor: how to treat. (17912112)
2007
23
A newborn baby with a tumor protruding from the mouth. Diagnosis: congenital gingival granular cell tumor. (17994174)
2007
24
Granular cell tumor of the breast. (17924412)
2007
25
An ultrastructural and immunohistochemical study of a combined submucosal granular cell tumor and lipoma of the colon showing a unique nodule-in-nodule structure: putative implication of CD34 or prominin-2-positive stromal cells in its histopathogenesis. (16673119)
2006
26
What is your diagnosis? Granular cell tumor. (15732430)
2005
27
Preoperative diagnosis of a mediastinal granular cell tumor by EUS-FNA: a case report and review of the literature. (15943858)
2005
28
Granular cell tumor of the orbit: magnetic resonance imaging characteristics. (16234712)
2005
29
Pulmonary malignant granular cell tumor. (14613555)
2003
30
Diagnosis of malignant granular cell tumor by fine needle aspiration cytology:. (11726096)
2001
31
Fine needle aspiration cytology of granular cell tumor in the breast of a male. (11726115)
2001
32
Immunohistochemical study of a granular cell tumor on the tongue of a dog. (12024318)
2001
33
Symptomatic granular cell tumor involving the pituitary gland in a dog: a case report and review of the literature. (11355666)
2001
34
Hilar pulmonary granular cell tumor: a case report and review of the literature. (10982303)
2000
35
Granular Cell Tumor Presenting as an Axillary Mass: Correlation Between Clinical, Radiologic, and Cytologic Findings. (11348401)
2000
36
Granular cell tumor of the presacral space. (10749272)
2000
37
Fine Needle Aspiration Cytology and Histologic Findings of Granular Cell Tumor of the Breast: Review of 19 Cases with Clinical/Radiologic Correlation. (11348331)
2000
38
Granular cell tumor: a review and update. (10410172)
1999
39
Benign granular cell tumor of the breast: a misleading disease. (10426131)
1999
40
Granular cell tumor of the pituitary stalk. (9746304)
1998
41
Granular cell tumor of the larynx in a six-year-old child: case report and review of the literature. (9745182)
1998
42
Granular cell tumor of the duodenum: a case report. (9772076)
1998
43
Atypical granular cell tumor of the neurohypophysis: a case report with review of the literature. (9737119)
1998
44
Coexistence of granular cell tumor and ipsilateral infiltrating ductal carcinoma of the breast. (9386062)
1997
45
Intramuscular malignant granular cell tumor. (9060104)
1997
46
Granular cell ameloblastoma versus central odontogenic granular cell tumor. (9231174)
1997
47
Plexiform granular cell tumor. A report of two cases. (7802168)
1994
48
Multicentric granular cell tumor of the heart presenting with aortic dissection. (8010821)
1994
49
Granular cell tumor of the vulva. (8346110)
1993
50
Treatment of granular cell tumor of the esophagus by endoscopic injection of dehydrated alcohol. (1595659)
1992

Genetic Variations for Granular Cell Tumor

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Expression for genes affiliated with Granular Cell Tumor

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Granular Cell Tumor

Search GEO for disease gene expression data for Granular Cell Tumor.

Pathways for genes affiliated with Granular Cell Tumor

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4Cell Signaling Technology
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Pathways related to Granular Cell Tumor according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8ENO2, NGFR, NTRK1, SYP, UCHL1, S100B

Compounds for genes affiliated with Granular Cell Tumor

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44Novoseek, 24HMDB, 28IUPHAR, 11DrugBank, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Granular Cell Tumor according to GeneCards/GeneDecks:

(show top 50)    (show all 79)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8CALB2
2glycogen44 2411.7SYP
3glutamate4410.6NGFR, NTRK1
4orcein4410.5VIM, S100B, DES
5reticulin4410.5VIM, S100B, DES, SYP
6toluidine4410.4VIM, S100A1, DES, ENO2
7s 1004410.4VIM, S100B, DES, SYP, ENO2
8nmda44 2811.3SYP, VIM
9dopamine44 28 11 2413.3CALB2, NTRK1, NGFR, ENO2
10dbc-amp4410.3VIM, S100B, SYP, NGFR, ENO2
11creatinine4410.3MPZ, SYP, NTRK1, SERPINA1, CEACAM3
12biotin44 11 2412.2INHA, DES, MPZ, S100A1, VIM
13tellurium4410.2NGFR, MPZ
14bromodeoxyuridine4410.2VIM, S100B, MPZ, DES, ENO2
15formaldehyde44 2411.2VIM, S100B, DES, SYP, ENO2
16catecholamine4410.2VIM, S100B, SYP, NTRK1, NGFR, ENO2
17silver4410.2CALB2, S100A1, DES, SYP, ENO2
18l-amino acid4410.1S100B, SYP, ENO2
19acth4410.1S100B, SYP, INHA, SERPINA1, ENO2, CEACAM3
20acetylcholine44 49 28 11 2414.1CALB2, S100A1, SYP, NTRK1, NGFR, ENO2
21gaba4410.1VIM, CALB2, S100B, SYP, NGFR, ENO2
22serine4410.1S100B, UCHL1, MPZ, DES, SYP
23ethanol44 49 11 2413.1CALB2, S100B, DES, SYP, NGFR, SERPINA1
24ganglioside4410.1VIM, MPZ, DES, SYP, NTRK1, NGFR
25choline44 11 2412.1VIM, CALB2, S100B, SYP, NTRK1, NGFR
2612-o-tetradecanoylphorbol 13-acetate4410.1VIM, UCHL1, DES, NTRK1, NGFR
27forskolin44 49 1112.0VIM, S100B, SYP, NGFR, INHA, ENO2
28methionine4410.0VIM, S100B, MPZ, DES, SERPINA1
29cyclic amp44 2411.0VIM, S100B, DES, SYP, NTRK1, NGFR
30mucicarmine4410.0VIM, CALB2, S100B, S100A1, DES, SYP
31k252a4410.0NGFR, NTRK1, VIM
32b 7234410.0VIM, CALB2, S100B, S100A1, DES, SYP
33estradiol44 11 2412.0VIM, DES, SYP, NTRK1, INHA, BOK
34iron44 2411.0VIM, S100B, S100A1, DES, SERPINA1, ENO2
35lactate4410.0VIM, S100B, MLANA, DES, NTRK1, ENO2
36testosterone44 59 11 2412.9VIM, CALB2, S100B, DES, SYP, NTRK1
37aspartate449.9VIM, S100B, MPZ, NTRK1, ENO2, CEACAM3
38steroid449.9CALB2, MLANA, MPZ, DES, SYP, NGFR
39cyanine449.8CEACAM3, CALB2
40thymidine44 2410.8CALB2, S100B, DES, NGFR, SERPINA1, ENO2
41retinoic acid44 2410.7VIM, S100B, S100A1, DES, SYP, NTRK1
42vegf449.7VIM, S100B, DES, SYP, NTRK1, NGFR
43cysteine449.7VIM, S100B, S100A1, UCHL1, MPZ, DES
44lipid449.7VIM, S100B, MPZ, SYP, NTRK1, NGFR
45oxygen44 2410.7S100B, DES, NTRK1, NGFR, SERPINA1, ENO2
46nitric oxide44 11 2411.6CALB2, S100B, S100A1, DES, SYP, NTRK1
47hematoxylin449.5SYP, NGFR, INHA, ENO2, CEACAM3, DES
48paraffin449.2VIM, CALB2, S100B, S100A1, MLANA, DES
49progesterone44 59 28 11 2413.1MPZ, DES, SYP, NTRK1, NGFR, INHA
50tyrosine449.1DES, MPZ, UCHL1, S100A1, S100B, CALB2

GO Terms for genes affiliated with Granular Cell Tumor

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16Gene Ontology
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Cellular components related to Granular Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:04302510.0INHA, NTRK1, UCHL1, S100B

Molecular functions related to Granular Cell Tumor according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1S100 protein bindingGO:04454810.2S100A1, S100B
2nerve growth factor bindingGO:0484069.9NGFR, NTRK1
3identical protein bindingGO:0428029.7SERPINA1, VIM, S100B, S100A1, DES, SYP

Products for genes affiliated with Granular Cell Tumor

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Sources for Granular Cell Tumor

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet