MCID: GRN007
MIFTS: 40

Granuloma Annulare

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Granuloma Annulare

MalaCards integrated aliases for Granuloma Annulare:

Name: Granuloma Annulare 37 12 72 49 51 41 14 69
Granulome Annulare 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3777
ICD10 32 L92.0
MeSH 41 D016460
NCIt 46 C3470
UMLS 69 C0085074

Summaries for Granuloma Annulare

NIH Rare Diseases : 49 Granuloma annulare is a long-term (chronic) skin disease consisting of a rash with reddish bumps arranged in a circle or ring. The most commonly affected areas are the forearms, hands and feet. The lesions associated with granuloma annulare usually resolve without treatment. Strong steroids (applied as a cream or injection) are sometimes used to clear the rash more quickly. Most symptoms will disappear within 2 years (even without treatment), but recurrence is common. The underlying cause of granuloma annulare is unknown. Last updated: 10/9/2015

MalaCards based summary : Granuloma Annulare, also known as granulome annulare, is related to necrobiosis lipoidica and multicentric reticulohistiocytosis. An important gene associated with Granuloma Annulare is F13A1 (Coagulation Factor XIII A Chain), and among its related pathways/superpathways is Interleukin-4 and 13 signaling. The drugs Levofloxacin and Minocycline have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and bone, and related phenotype is respiratory system.

Wikipedia : 72 Granuloma annulare is a fairly rare, chronic skin condition which presents as reddish bumps on the skin... more...

Related Diseases for Granuloma Annulare

Diseases related to Granuloma Annulare via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 137)
# Related Disease Score Top Affiliating Genes
1 necrobiosis lipoidica 30.8 GLI1 TNFRSF1B
2 multicentric reticulohistiocytosis 30.0 F13A1 VIM
3 fibrous histiocytoma 29.4 F13A1 VIM
4 diabetes mellitus 10.2
5 lymphoma 10.2
6 herpes zoster 10.2
7 angiolipoma 10.1 F13A1 VIM
8 hepatitis 10.1
9 thyroiditis 10.1
10 hashimoto thyroiditis 10.1
11 mycosis fungoides 10.1
12 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1
13 leukemia 10.1
14 fibrous meningioma 10.1 F13A1 VIM
15 juvenile xanthogranuloma 10.1 F13A1 VIM
16 dermatitis 10.1
17 acquired immunodeficiency syndrome 10.1
18 cutaneous fibrous histiocytoma 10.1 F13A1 VIM
19 uveitis 10.0
20 hemangiopericytoma, malignant 10.0 F13A1 VIM
21 hepatitis b 10.0
22 lichen sclerosus 10.0
23 streptococcal group a invasive disease 10.0
24 mid-dermal elastolysis 10.0
25 malignant fibroxanthoma 10.0 F13A1 VIM
26 mycobacterium tuberculosis 1 9.9
27 hepatitis c virus 9.9
28 myelodysplastic syndrome 9.9
29 episodic pain syndrome, familial, 1 9.9
30 b-cell lymphomas 9.9
31 sarcoma 9.9
32 hepatitis c 9.9
33 adenocarcinoma 9.9
34 syphilis 9.9
35 scabies 9.9
36 leprosy 3 9.8
37 aging 9.8
38 erythema multiforme 9.8
39 skin sarcoidosis 9.8
40 hyperparathyroidism 9.8
41 hypothyroidism 9.8
42 contact dermatitis 9.8
43 histiocytosis 9.8
44 secondary syphilis 9.8
45 granulomatous dermatitis 9.8
46 angiokeratoma 9.8
47 epithelioid sarcoma 9.8
48 lupus erythematosus 9.8
49 lichen planus 9.8
50 anterior uveitis 9.8

Graphical network of the top 20 diseases related to Granuloma Annulare:



Diseases related to Granuloma Annulare

Symptoms & Phenotypes for Granuloma Annulare

MGI Mouse Phenotypes related to Granuloma Annulare:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 9.02 F13A1 GLI1 STAB1 TNFRSF1B VIM

Drugs & Therapeutics for Granuloma Annulare

Drugs for Granuloma Annulare (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Levofloxacin Approved, Investigational 100986-85-4 149096
2
Minocycline Approved, Investigational 10118-90-8 5281021
3
Ofloxacin Approved 82419-36-1 4583
4
Rifampin Approved 13292-46-1 5381226 5458213
5 Anti-Bacterial Agents
6 Antibiotics, Antitubercular
7 Anti-Infective Agents
8 Antitubercular Agents
9 Cytochrome P-450 CYP1A2 Inhibitors
10 Cytochrome P-450 CYP3A Inducers
11 Cytochrome P-450 Enzyme Inhibitors
12 Nucleic Acid Synthesis Inhibitors
13 Renal Agents
14 Topoisomerase Inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Ultraviolet B (UVB) Light Therapy in the Treatment of Skin Conditions With Altered Dermal Matrix Completed NCT00129428 Phase 1, Phase 2
2 Granuloma Annulare Treated With Rifampin, Ofloxacin, and Minocycline Combination Therapy Completed NCT00720980
3 Proteomic Analysis of Sweat in Cutaneous Conditions Recruiting NCT02768090
4 UVA1 Light for Scleroderma and Similar Conditions Terminated NCT00476697

Search NIH Clinical Center for Granuloma Annulare

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Granuloma Annulare cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: granuloma annulare

Genetic Tests for Granuloma Annulare

Anatomical Context for Granuloma Annulare

MalaCards organs/tissues related to Granuloma Annulare:

38
Skin, Thyroid, Bone, B Cells, T Cells, Breast, Tongue

Publications for Granuloma Annulare

Articles related to Granuloma Annulare:

(show top 50) (show all 610)
# Title Authors Year
1
Subcutaneous granuloma annulare involving the scalp. ( 29205476 )
2018
2
Malignancy-associated generalized perforating granuloma annulare. ( 29318643 )
2018
3
Skin-colored papules on the elbows with a granuloma-annulare-like histological pattern. ( 29328553 )
2018
4
Granuloma Annulare and Radial Pulse Therapy: Preliminary Findings. ( 29410728 )
2018
5
Granuloma annulare treated with narrowband UVB phototherapy. ( 29267455 )
2017
6
Successful Treatment of Generalized Granuloma Annulare with Pentoxifylline. ( 28584765 )
2017
7
Granuloma Annulare ( 29083715 )
2017
8
Case of successful treatment of subcutaneous granuloma annulare with local hyperthermia. ( 28636080 )
2017
9
Granuloma Annulare and Morphea: Correlation with Borrelia burgdorferi Infections and Chlamydia-related Bacteria. ( 29110020 )
2017
10
Deep Granuloma Annulare Mimicking Inflamed Cysts in a Teenager. ( 28419540 )
2017
11
Papular Granuloma Annulare of Palms and Soles. ( 29204409 )
2017
12
Dermoscopy of Granuloma Annulare: A Clinical and Histological Correlation Study. ( 28099955 )
2017
13
Granuloma annulare: relationship to diabetes mellitus, thyroid disorders and tuberculin skin test. ( 28490896 )
2017
14
Disseminated eruptive granuloma annulare induced by levetiracetam. ( 28095713 )
2017
15
Interstitial Granulomatous Dermatitis with Granuloma Annulare-Like Pattern Following Liposuction. ( 28946733 )
2017
16
Granuloma annulare can occur on a scar, mimicking sarcoidosis. ( 28929530 )
2017
17
Borderline Tuberculoid Leprosy Masquerading as Granuloma Annulare: A Clinical and Histological Pitfall. ( 28328616 )
2017
18
Bacilli-containing granuloma with subsequent granuloma annulare-like eruptions following Bacillus Calmette-GuAcrin vaccination. ( 29373237 )
2017
19
Granuloma Annulare Possibly Secondary to Oral Treatment With Topiramate. ( 28712438 )
2017
20
Granuloma Annulare Secondary to Vemurafenib Therapy for Lung Adenocarcinoma. ( 29036262 )
2017
21
Chronic Hepatitis with Liver Granulomas in a Patient with Granuloma Annulare: A Case Report and Review of the Literature. ( 28326206 )
2017
22
Granuloma annulare associated with immune checkpoint inhibitors. ( 28983973 )
2017
23
Perforating granuloma annulare within the red dye of a tattoo. ( 29050456 )
2017
24
Granuloma Annulare: A Focused Review of Therapeutic Options. ( 29230666 )
2017
25
Consecutive occurrence of isotopic and isomorphic response in a patient: Patchy granuloma annulare arising in the site of herpes zoster scar and seborrhoeic dermatitis. ( 28670742 )
2017
26
Granuloma annulare: a case treated with infliximab successfully. ( 28166622 )
2017
27
A Case of Granuloma Annulare Associated with Secukinumab Use. ( 28611928 )
2017
28
Florid Granuloma Annulare-Like Reaction in Regional Lymph Nodes After "Regression" of Red Pigment in Tattoos. ( 29140806 )
2017
29
Actinic Granuloma Annulare With Scarring and Open Comedones. ( 28244938 )
2017
30
Case for diagnosis. Patch granuloma annulare. ( 29186265 )
2017
31
Coexistence of morphea and granuloma annulare: a rare case report. ( 29166431 )
2017
32
Antimalarial therapy for granuloma annulare: Results of a retrospective analysis. ( 28325398 )
2017
33
Generalized Granuloma Annulare in a Cirrhotic Patient Treated with Narrowband Ultraviolet B Therapy. ( 26955167 )
2016
34
Pediatric Dermatology Photoquiz: A 9-Year Old Girl with Papules on Her Hands. Papular umbilicated granuloma annulare. ( 26758094 )
2016
35
Granuloma annulare: Clinical and histologic variants, epidemiology, and genetics. ( 27543209 )
2016
36
Granuloma annulare: Pathogenesis, disease associations and triggers, and therapeutic options. ( 27543210 )
2016
37
Subcutaneous Granuloma Annulare: A Diagnostic Conundrum-Learning From Mistakes. ( 26785090 )
2016
38
A Case of Acute-Onset, Painful Acral Granuloma Annulare. ( 26848233 )
2016
39
Penile Granuloma Annulare. ( 27502267 )
2016
40
Vemurafenib-induced granuloma annulare. ( 26972200 )
2016
41
Granuloma annular-like lesions as a manifestation of eosinophilic granulomatosis with polyangiitis. ( 27575892 )
2016
42
Case of disseminated granuloma annulare with giant plaques. ( 27154540 )
2016
43
Pressure-induced localised granuloma annulare following use of an elbow splint. ( 27613591 )
2016
44
Intraorbital granuloma annulare in an elderly patient. ( 27163779 )
2016
45
Generalized granuloma annulare successfully treated with narrowband ultraviolet B and anti-hepatitis C virus therapy. ( 26891771 )
2016
46
Resolution of disseminated granuloma annulare with removal of surgical hardware. ( 27529714 )
2016
47
Palisaded Granuloma on the Nose: An Atypical Presentation of Granuloma Annulare. ( 28033153 )
2016
48
Acute myelogenous leukemia presenting with uveitis, optic disc edema, and granuloma annulare: Case report. ( 27769343 )
2016
49
IMAGES IN CLINICAL MEDICINE. Generalized Granuloma Annulare Associated with Diabetes Mellitus. ( 27602682 )
2016
50
Disseminated granuloma annulare responding to narrowband UVB phototherapy. ( 26580147 )
2016

Variations for Granuloma Annulare

Expression for Granuloma Annulare

Search GEO for disease gene expression data for Granuloma Annulare.

Pathways for Granuloma Annulare

Pathways related to Granuloma Annulare according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.86 F13A1 TNFRSF1B VIM

GO Terms for Granuloma Annulare

Sources for Granuloma Annulare

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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