MCID: GRN007
MIFTS: 37

Granuloma Annulare malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Granuloma Annulare

Aliases & Descriptions for Granuloma Annulare:

Name: Granuloma Annulare 38 12 50 52 42 14 69
Granulome Annulare 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3777
ICD10 33 L92.0
MeSH 42 D016460
NCIt 47 C3470
UMLS 69 C0085074

Summaries for Granuloma Annulare

NIH Rare Diseases : 50 granuloma annulare is a long-term (chronic) skin disease consisting of a rash with reddish bumps arranged in a circle or ring. the most commonly affected areas are the forearms, hands and feet. the lesions associated with granuloma annulare usually resolve without treatment. strong steroids (applied as a cream or injection) are sometimes used to clear the rash more quickly. most symptoms will disappear within 2 years (even without treatment), but recurrence is common. the underlying cause of granuloma annulare is unknown. last updated: 10/9/2015

MalaCards based summary : Granuloma Annulare, also known as granulome annulare, is related to necrobiosis lipoidica and congenital myasthenic syndrome. An important gene associated with Granuloma Annulare is F13A1 (Coagulation Factor XIII A Chain), and among its related pathways/superpathways is Interleukin-4 and 13 signaling. The drugs Rifampin and Minocycline have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and thyroid, and related phenotype is respiratory system.

Wikipedia : 71 Granuloma annulare is a fairly rare, chronic dermatological condition which presents as reddish bumps on... more...

Related Diseases for Granuloma Annulare

Diseases related to Granuloma Annulare via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
id Related Disease Score Top Affiliating Genes
1 necrobiosis lipoidica 10.4
2 congenital myasthenic syndrome 10.1 F13A1 VIM
3 cortical blindness 10.1 F13A1 VIM
4 lymphoma 10.1
5 postgerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma 10.1 F13A1 VIM
6 herpes zoster 10.1
7 cavernous sinus meningioma 10.1 F13A1 VIM
8 signet ring cell adenocarcinoma 10.1 GLI1 TNFRSF1B
9 dyslexia 10.1 F13A1 VIM
10 diarrhea, chronic, with villous atrophy 10.0 F13A1 VIM
11 neutrophil immunodeficiency syndrome 10.0 F13A1 VIM
12 mycosis fungoides 10.0
13 thyroiditis 10.0
14 hepatitis 10.0
15 leukemia 10.0
16 caroli disease 10.0 F13A1 VIM
17 acquired immunodeficiency syndrome 10.0
18 uveitis 9.9
19 juvenile xanthogranuloma 9.9 F13A1 VIM
20 dermatitis 9.9
21 lichen sclerosus 9.9
22 mid-dermal elastolysis 9.9
23 hepatitis b 9.9
24 b-cell lymphomas 9.8
25 sarcoma 9.8
26 scabies 9.8
27 hepatitis c virus 9.8
28 tuberculosis 9.8
29 myelodysplastic syndrome 9.8
30 hepatitis c 9.8
31 syphilis 9.8
32 erythema multiforme 9.7
33 angiokeratoma 9.7
34 contact dermatitis 9.7
35 anterior uveitis 9.7
36 adenocarcinoma 9.7
37 epithelioid sarcoma 9.7
38 hyperparathyroidism 9.7
39 histiocytosis 9.7
40 scleromyxedema 9.7
41 secondary syphilis 9.7
42 lupus erythematosus 9.7
43 multicentric reticulohistiocytosis 9.7
44 lichen planus 9.7
45 porphyria 9.6
46 angioimmunoblastic t-cell lymphoma 9.6
47 elastosis perforans serpiginosa 9.6
48 maturity-onset diabetes of the young 9.6
49 skin sarcoidosis 9.6
50 eye disease 9.6

Graphical network of the top 20 diseases related to Granuloma Annulare:



Diseases related to Granuloma Annulare

Symptoms & Phenotypes for Granuloma Annulare

MGI Mouse Phenotypes related to Granuloma Annulare:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 respiratory system MP:0005388 8.92 F13A1 GLI1 TNFRSF1B VIM

Drugs & Therapeutics for Granuloma Annulare

Drugs for Granuloma Annulare (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifampin Approved 13292-46-1 5458213 5381226
2
Minocycline Approved, Investigational 10118-90-8 5281021
3
Ofloxacin Approved 82419-36-1 4583
4
Levofloxacin Approved, Investigational 100986-85-4 149096
5 Cytochrome P-450 CYP1A2 Inhibitors
6 Cytochrome P-450 CYP3A Inducers
7 Cytochrome P-450 Enzyme Inhibitors
8 Topoisomerase Inhibitors
9 Nucleic Acid Synthesis Inhibitors
10 Anti-Bacterial Agents
11 Anti-Infective Agents
12 Renal Agents
13 Antibiotics, Antitubercular
14 Antitubercular Agents

Interventional clinical trials:


id Name Status NCT ID Phase
1 Ultraviolet B (UVB) Light Therapy in the Treatment of Skin Conditions With Altered Dermal Matrix Completed NCT00129428 Phase 1, Phase 2
2 Granuloma Annulare Treated With Rifampin, Ofloxacin, and Minocycline Combination Therapy Completed NCT00720980
3 Proteomic Analysis of Sweat in Cutaneous Conditions Recruiting NCT02768090
4 UVA1 Light for Scleroderma and Similar Conditions Terminated NCT00476697

Search NIH Clinical Center for Granuloma Annulare

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Granuloma Annulare cell therapies at LifeMap Discovery.

Cochrane evidence based reviews: granuloma annulare

Genetic Tests for Granuloma Annulare

Anatomical Context for Granuloma Annulare

MalaCards organs/tissues related to Granuloma Annulare:

39
Skin, Bone, Thyroid, B Cells, T Cells, Breast, Tongue

Publications for Granuloma Annulare

Articles related to Granuloma Annulare:

(show top 50) (show all 578)
id Title Authors Year
1
Generalised granuloma annulare associated with myelodysplastic syndrome. ( 27212203 )
2016
2
Coexistence of granuloma annulare and chronic spontaneous urticaria. ( 27579763 )
2016
3
Subcutaneous Granuloma Annulare: A Diagnostic Conundrum-Learning From Mistakes. ( 26785090 )
2016
4
Granuloma annulare: Clinical and histologic variants, epidemiology, and genetics. ( 27543209 )
2016
5
IMAGES IN CLINICAL MEDICINE. Generalized Granuloma Annulare Associated with Diabetes Mellitus. ( 27602682 )
2016
6
Disseminated granuloma annulare responding to narrowband UVB phototherapy. ( 26580147 )
2016
7
Granuloma annular-like lesions as a manifestation of eosinophilic granulomatosis with polyangiitis. ( 27575892 )
2016
8
Generalized granuloma annulare successfully treated with narrowband ultraviolet B and anti-hepatitis C virus therapy. ( 26891771 )
2016
9
Vemurafenib-induced granuloma annulare. ( 26972200 )
2016
10
A Case of Acute-Onset, Painful Acral Granuloma Annulare. ( 26848233 )
2016
11
Resolution of disseminated granuloma annulare with removal of surgical hardware. ( 27529714 )
2016
12
Granuloma annulare: Pathogenesis, disease associations and triggers, and therapeutic options. ( 27543210 )
2016
13
Intraorbital granuloma annulare in an elderly patient. ( 27163779 )
2016
14
Pediatric Dermatology Photoquiz: A 9-Year Old Girl with Papules on Her Hands. Papular umbilicated granuloma annulare. ( 26758094 )
2016
15
Generalized Granuloma Annulare in a Cirrhotic Patient Treated with Narrowband Ultraviolet B Therapy. ( 26955167 )
2016
16
Acute myelogenous leukemia presenting with uveitis, optic disc edema, and granuloma annulare: Case report. ( 27769343 )
2016
17
Palisaded Granuloma on the Nose: An Atypical Presentation of Granuloma Annulare. ( 28033153 )
2016
18
Pressure-induced localised granuloma annulare following use of an elbow splint. ( 27613591 )
2016
19
Case of disseminated granuloma annulare with giant plaques. ( 27154540 )
2016
20
Penile Granuloma Annulare. ( 27502267 )
2016
21
Perforating granuloma annulare in a young male following application of the tattoo. ( 26225344 )
2015
22
Sporotrichoid granuloma annulare-like dermatitis associated with systemic B-cell lymphoma. ( 26437282 )
2015
23
Does disseminated granuloma annulare require treatment? Thoughts on the definition of "disease" in dermatology. ( 26283583 )
2015
24
Treatment of recalcitrant granuloma annulare (GA) with adalimumab: A single-center, observational study. ( 26552891 )
2015
25
Perforating granuloma annulare: a case report and literature review. ( 25924054 )
2015
26
Granuloma annulare and necrobiosis lipoidica with sequential occurrence in a patient: report and review of literature. ( 25692078 )
2015
27
Multiple Granuloma Annulare in a 2-year-old Child. ( 26677301 )
2015
28
A Case of Subcutaneous Granuloma Annulare (SGA) in the Scalp of a Child: Histological Findings. ( 26218452 )
2015
29
Lichen sclerosus and granuloma annulare of the foreskin: a significant association. ( 26662156 )
2015
30
Successful treatment of generalized granuloma annulare with adalimumab. ( 25688452 )
2015
31
The efficacy of PUVA and narrowband UVB phototherapy in the management of generalised granuloma annulare. ( 26447167 )
2015
32
Granuloma Annulare Arising in Tumescent Anesthesia Injection Sites After Endovenous Ablation. ( 26418627 )
2015
33
NB-UVB phototherapy for generalized granuloma annulare. ( 26626163 )
2015
34
Granuloma Annulare. ( 26143416 )
2015
35
Dermoscopy of elastosis perforans serpiginosa: A useful tool to distinguish it from granuloma annulare. ( 26089077 )
2015
36
Successful treatment of subcutaneous granuloma annulare with bath-psoralen plus ultraviolet A therapy. ( 26249152 )
2015
37
Crystalline leaf venation: a dermoscopic clue for diagnosing granuloma annulare. ( 26629577 )
2015
38
JAMA Dermatology Patient Page. Granuloma Annulare. ( 26061960 )
2015
39
Treatment of generalized granuloma annulare - a systematic review. ( 25651003 )
2015
40
Monthly rifampicin, ofloxacin, and minocycline therapy for generalized and localized granuloma annulare. ( 25566894 )
2015
41
Management of Periocular Granuloma Annulare Using Topical Dapsone. ( 26203321 )
2015
42
Laser treatment of granuloma annulare: a review. ( 26474922 )
2015
43
Residents'corner February 2014. DeRmpath & Clinic: differential diagnosis in palisading non-infectious granulomas. Diagnosis: Case 1: Granuloma annulare. Case 2: Necrobiosis lipoidica. ( 24691245 )
2014
44
Atypical subcutaneous granuloma annulare on the digit: a case report. ( 24875515 )
2014
45
Thalidomide-induced granuloma annulare. ( 24819760 )
2014
46
Successful Treatment of Disseminated Granuloma Annulare With Narrowband UV-B Phototherapy. ( 25306869 )
2014
47
Scleromyxedema with histology resembling granuloma annulare. ( 25780962 )
2014
48
Childhood granuloma annulare: a review. ( 25279495 )
2014
49
Granuloma annulare as a possible new adverse effect of topiramate. ( 24168458 )
2014
50
Subcutaneous granuloma annulare of the penis associated with a urethral anomaly: case report and review of the literature. ( 24889683 )
2014

Variations for Granuloma Annulare

Expression for Granuloma Annulare

Search GEO for disease gene expression data for Granuloma Annulare.

Pathways for Granuloma Annulare

Pathways related to Granuloma Annulare according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.86 F13A1 TNFRSF1B VIM

GO Terms for Granuloma Annulare

Sources for Granuloma Annulare

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....