MCID: GRN007
MIFTS: 47

Granuloma Annulare malady

Skin diseases category

Summaries for Granuloma Annulare

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Granuloma annulare is a long-term (chronic) skin disease consisting of a rash with reddish bumps arranged in a circle or ring. last updated: 5/31/2013

MalaCards: Granuloma Annulare, also known as granulome annulare, is related to dermatitis and sarcoma. An important gene associated with Granuloma Annulare is F13A1 (coagulation factor XIII, A1 polypeptide), and among its related pathways are Development PDGF signaling via STATs and NF-kB and amb2 Integrin signaling. The compounds cilomilast and go 6976 have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and thyroid, and related mouse phenotypes are tumorigenesis and respiratory system.

Wikipedia:63 Granuloma annulare is a fairly rare, chronic dermatological autoimmune condition which presents as... more...

Aliases & Classifications for Granuloma Annulare

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8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

granuloma annulare 8 42 44 30 60
granulome annulare 8


External Ids:

Disease Ontology8 DOID:3777
NCIt39 C3470
MeSH34 D016460
ICD1025 L92.0

Related Diseases for Granuloma Annulare

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Granuloma Annulare:



Diseases related to granuloma annulare

Clinical Features for Granuloma Annulare

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Drugs & Therapeutics for Granuloma Annulare

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Granuloma Annulare cell therapies at LifeMap Discovery.

Genetic Tests for Granuloma Annulare

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Anatomical Context for Granuloma Annulare

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32MalaCards
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MalaCards organs/tissues related to Granuloma Annulare:

32
Skin, Bone, Thyroid, B cells, T cells, Breast, Endothelial, Monocytes, Testes, Bone marrow, Eye, Prostate

Animal Models for Granuloma Annulare or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Granuloma Annulare:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.0TNF
2MP:00053887.7MMP2, GLI1, F13A1, TNF

Publications for Granuloma Annulare

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50PubMed
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Articles related to Granuloma Annulare:

(show top 50)    (show all 518)
idTitleAuthorsYear
1
Treatment of disseminated granuloma annulare with oral vitamin E: 'primum nil nocere'. (23988344)
2013
2
Granuloma annulare, autoimmune thyroiditis, and lichen sclerosus in a woman: randomness or significant association? (23738153)
2013
3
Disseminated granuloma annulare: study on eight cases. (23771077)
2013
4
Granuloma annulare mimicking multicentric reticulohistiocytosis. (24314776)
2013
5
A rare case of granuloma annulare in a 6-year-old child with type 1 diabetes. (23729613)
2013
6
Granuloma annulare photoinduced by paroxetine. (22212003)
2012
7
Granuloma annulare of the penis in a seven-year-old boy. (21091089)
2011
8
A rare variant of generalized granuloma annulare presenting with chronic Epstein-Barr virus infection: coincidence or association? (22367377)
2011
9
Annular elastolytic giant cell granuloma associated with temporal arteritis leading to blindness. (21962191)
2011
10
Treatment of widespread granuloma annulare with adalimumab: a case report. (22125659)
2011
11
Eruptive generalized granuloma annulare presenting with numerous micropapules. (20465627)
2010
12
Education and imaging. Gastrointestinal: Improvement of granuloma annulare with anti-tumour necrosis factor alpha therapy for Crohn's disease. (20136975)
2010
13
Bilateral granuloma annulare of the external ear. (20146967)
2010
14
Isomorphic and isotopic phenomenon occurring simultaneously in a case of granuloma annulare. (19439892)
2009
15
Colocalization of C4d deposits/CD68+ macrophages in rheumatoid nodule and granuloma annulare: immunohistochemical evidence of a complement-mediated mechanism in fibrinoid necrosis. (18339486)
2008
16
Generalized granuloma annulare and giant cell arteritis. (18799066)
2008
17
Treatment of granuloma annulare with the 595 nm pulsed dye laser in a pediatric patient. (18429778)
2008
18
Histological and immunohistochemical study of granuloma annulare and subcutaneous granuloma annulare in children. (17448194)
2007
19
Generalized granuloma annulare and eruptive folliculitis in an HIV-positive man: resolution after antiretroviral therapy. (17714140)
2007
20
Generalized granuloma annulare resolving to anetoderma. (17459302)
2006
21
Open comedones overlying granuloma annulare in a photoexposed area. (16948833)
2006
22
Treatment of granuloma annulare with the 585 nm pulsed dye laser. (16188200)
2005
23
Successful treatment of granuloma annulare with imiquimod cream 5%: a report of four cases. (16396814)
2005
24
Pimecrolimus 1% cream in the treatment of disseminated granuloma annulare. (15949015)
2005
25
Subcutaneous granuloma annulare: an unusual presentation in the eyelids and scalp. (16327476)
2005
26
The spectrum of primary cutaneous elastolytic granulomas and their distinction from granuloma annulare: a clinicopathological analysis. (14987232)
2004
27
Topical tacrolimus in granuloma annulare and necrobiosis lipoidica. (15099394)
2004
28
Paediatric periocular granuloma annulare. (12631034)
2003
29
Abundance of interstitial heparan sulfate in granuloma annulare but not in other mucinous skin diseases. (12358809)
2002
30
Granuloma annulare possibly triggered by antitetanus vaccination. (12428851)
2002
31
HIV-associated granuloma annulare (HAGA): a report of six cases. (10809877)
2000
32
PUVA therapy of granuloma annulare. (11012606)
2000
33
Eosinophils are not a clue to the pathogenesis of granuloma annulare. (9504666)
1998
34
Resolution of generalized granuloma annulare with isotretinoin therapy. (8737887)
1996
35
Cyclosporine in the treatment of generalized granuloma annulare. (8113463)
1994
36
Absence of carbohydrate intolerance in granuloma annulare. (8157800)
1994
37
Localized granuloma annulare. Histopathological and direct immunofluorescence study of early lesions, and the adjacent normal-looking skin of actively spreading lesions. (8311184)
1993
38
Familial granuloma annulare. (1358835)
1992
39
Granuloma annulare and disseminated herpes zoster. (1737692)
1992
40
Seasonally recurrent granuloma annulare of the elbows. (2032375)
1991
41
Generalized granuloma annulare: clinical and laboratory findings in 100 patients. (2913080)
1989
42
A comparative histopathologic study of generalized and localized granuloma annulare. (2712247)
1989
43
Elastic tissue changes in generalized granuloma annulare. (2802105)
1989
44
Biochemical and immunohistochemical comparison of collagen in granuloma annulare and skin sarcoidosis. (2568042)
1989
45
Circulating immune complexes in granuloma annulare. (3263083)
1988
46
Resolution of cutaneous lesions of granuloma annulare by intralesional injection of human fibroblast interferon. (3389846)
1988
47
Disseminated atypical granuloma annulare. (3301952)
1987
48
Necrobiosis lipoidica and granuloma annulare. (6693593)
1984
49
Glycosylated haemoglobin in patients with necrobiosis lipoidica and granuloma annulare. (7296959)
1981
50
Necrobiosis lipoidica (diabeticorum?) a histologic study and comparison with granuloma annulare. (18113617)
1949

Genetic Variations for Granuloma Annulare

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Expression for genes affiliated with Granuloma Annulare

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Granuloma Annulare

Search GEO for disease gene expression data for Granuloma Annulare.

Pathways for genes affiliated with Granuloma Annulare

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37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN
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Pathways related to Granuloma Annulare according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Development PDGF signaling via STATs and NF-kB
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9.1MMP2, TNF
29.1MMP2, TNF
3
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9.1MMP2, TNF

Compounds for genes affiliated with Granuloma Annulare

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Granuloma Annulare according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1cilomilast449.5MMP2, TNF
2go 697644 5910.5TNF, MMP2
3ciglitazone44 2810.5MMP2, TNF
48-isoprostane449.4MMP2, TNF
5ns 39844 5910.4TNF, MMP2
6pentoxifylline44 1110.4MMP2, TNF
7melphalan44 1110.4MMP2, TNF
8pioglitazone44 49 28 1112.4MMP2, TNF
9pdtc449.4TNF, MMP2
10procollagen449.4F13A1, MMP2
11sp 60012544 5910.3TNF, MMP2
12atorvastatin44 49 28 11 2413.3MMP2, TNF
13prednisolone44 28 1111.3TNF, MMP2
14hydrocortisone44 2 59 1112.2MMP2, TNF
15rosiglitazone44 49 28 11 2413.2MMP2, TNF
16troglitazone44 28 59 1112.1MMP2, TNF
17herbimycin a44 5910.1TNF, MMP2
18egcg449.0MMP2, TNF
19pd 98,059448.8MMP2, GLI1, TNF
20vegf448.8MMP2, TNF, F13A1
21tgf beta1448.8MMP2, TNF

GO Terms for genes affiliated with Granuloma Annulare

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16Gene Ontology
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Biological processes related to Granuloma Annulare according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to hypoxiaGO:0016669.1MMP2, TNF
2cellular response to amino acid stimulusGO:0712308.8MMP2, TNF

Products for genes affiliated with Granuloma Annulare

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Sources for Granuloma Annulare

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet