MCID: GRN007
MIFTS: 44

Granuloma Annulare malady

Skin category

Summaries for Granuloma Annulare

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Granuloma annulare is a long-term (chronic) skin disease consisting of a rash with reddish bumps arranged in a circle or ring. last updated: 5/31/2013

MalaCards: Granuloma Annulare, also known as granulome annulare, is related to lichen planus and adenocarcinoma. An important gene associated with Granuloma Annulare is F13A1 (coagulation factor XIII, A1 polypeptide), and among its related pathways are Development PDGF signaling via STATs and NF-kB and amb2 Integrin signaling. The compounds cilomilast and go 6976 have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, thyroid and breast, and related mouse phenotypes are tumorigenesis and respiratory system.

Wikipedia:64 Granuloma annulare is a fairly rare, chronic dermatological autoimmune condition which presents as... more...

Aliases & Classifications for Granuloma Annulare

Sources:
8Disease Ontology, 43NIH Rare Diseases, 45Novoseek, 31LifeMap Discovery™, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin


Aliases & Descriptions:

granuloma annulare 8 43 45 31 61
granulome annulare 8


External Ids:

Disease Ontology8 DOID:3777
NCIt40 C3470
MeSH35 D016460
ICD1025 L92.0

Related Diseases for Granuloma Annulare

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Granuloma Annulare:



Diseases related to granuloma annulare

Clinical Features for Granuloma Annulare

Drugs & Therapeutics for Granuloma Annulare

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Granuloma Annulare

Drug clinical trials:

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Search CenterWatch for Granuloma Annulare

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Granuloma Annulare cell therapies at LifeMap Discovery.

Genetic Tests for Granuloma Annulare

Anatomical Context for Granuloma Annulare

Sources:
33MalaCards
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MalaCards organs/tissues related to Granuloma Annulare:

33
Bone marrow, Thyroid, Breast, Skin, Prostate, Monocytes, T cells, B cells, Endothelial

Animal Models for Granuloma Annulare or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Granuloma Annulare:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.0TNF
2MP:00053887.7MMP2, GLI1, F13A1, TNF

Publications for Granuloma Annulare

Sources:
51PubMed
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Articles related to Granuloma Annulare:

(show top 50)    (show all 513)
idTitleAuthorsYear
1
Periocular Granuloma Annulare: A Case Report and Review of Literature. (23551387)
2013
2
Localized interstitial granuloma annulare induced by subcutaneous injections for desensitization. (24011321)
2013
3
Periorbital granuloma annulare successfully treated with tacrolimus 0.1% ointment. (23432464)
2013
4
A rare case of granuloma annulare in a 6-year-old child with type 1 diabetes. (23729613)
2013
5
Granuloma annulare responsive to oral calcitriol. (22182391)
2012
6
What is your diagnosis? Perforating granuloma annulare. (21488567)
2011
7
Concomitant occurrence of patch granuloma annulare and classical granuloma annulare. (21352310)
2011
8
Secondary syphilis with an interstitial granuloma annulare-like histopathologic pattern. (21251035)
2011
9
Treatment of disseminated granuloma annulare with allopurinol: case report. (20136918)
2010
10
Successful treatment of disseminated granuloma annulare with methotrexate. (20586778)
2010
11
Generalized granuloma annulare with tuberculoid granulomas: a rare histopathological variant. (20061743)
2010
12
Collagen-elastic tissue changes and vascular involvement in granuloma annulare: a review of 35 cases. (19017038)
2009
13
Generalized granuloma annulare treated with methylaminolevulinate photodynamic therapy. (19155615)
2009
14
Successful treatment of perforating granuloma annulare with 0.1% tacrolimus ointment. (18608717)
2008
15
Photo quiz. Case 8. Granuloma annulare. (18193512)
2007
16
Subcutaneous (deep) granuloma annulare in children: a possible mimicker of epithelioid sarcoma. (17613044)
2007
17
Atypical generalized granuloma annulare associated with two visceral cancers. (16631952)
2006
18
UVA1 phototherapy for disseminated granuloma annulare. (15752123)
2005
19
Low serum insulin values in children with multiple lesions of granuloma annulare: a prospective study. (15649188)
2005
20
Two case reports of cutaneous adverse reactions following hepatitis B vaccine: lichen planus and granuloma annulare. (15324406)
2004
21
Granuloma annulare with a mycosis fungoides-like distribution and palisaded granulomas of CD68-positive histiocytes. (15243522)
2004
22
Subcutaneous granuloma annulare in an adult. (12793032)
2003
23
Generalized granuloma annulare associated with Plummer's disease. (12224712)
2002
24
Interstitial mycosis fungoides, a variant of mycosis fungoides resembling granuloma annulare and inflammatory morphea. (11972709)
2002
25
Sweet's syndrome in association with generalized granuloma annulare in a patient with previous breast carcinoma. (11722452)
2001
26
Chronic hepatitis C virus infection associated with a generalized granuloma annulare. (11044822)
2000
27
Nodular tertiary syphilis mimicking granuloma annulare. (10640938)
2000
28
Granuloma annulare localized to the palms. (10426910)
1999
29
Subcutaneous granuloma annulare with Hodgkin's disease. (8708153)
1996
30
Systemic scleroderma and perforating granuloma annulare: differential diagnosis from calcinosis. (8726647)
1996
31
Granuloma annulare and necrobiosis lipoidica tissue reactions as a manifestation of systemic disease. (8543311)
1996
32
Localized granuloma annulare and autoimmune thyroid disease. Are they associated? (8680298)
1995
33
Ichthyosis. Basal cell carcinoma. Granuloma annulare. Self-assessment examination of the American Academy of Dermatology. (8277025)
1994
34
Granuloma annulare: an immunohistochemical study. (8040462)
1994
35
Granuloma annulare in patients with malignant lymphoma: clinicopathologic study of thirteen new cases. (8021370)
1994
36
Granuloma annulare localized to the shaft of the penis. (8159932)
1993
37
Granuloma annulare of the penis. (1290479)
1992
38
Isolation of Borrelia burgdorferi from a skin lesion in a patient with granuloma annulare. (1800376)
1991
39
Photochemotherapy of generalized granuloma annulare. (2310208)
1990
40
Epidermal dendritic S100 positive cells in necrobiosis lipoidica and granuloma annulare. (2265092)
1990
41
Granuloma annulare and gold therapy. (2221950)
1990
42
Perforating granuloma annulare and diabetes mellitus. (2397977)
1990
43
Elastic tissue changes in generalized granuloma annulare. (2802105)
1989
44
Monocyte-modulating activities in the sera of patients with granuloma annulare. (3053834)
1988
45
Remission of human immunodeficiency virus-associated generalized granuloma annulare under zidovudine therapy. (3204184)
1988
46
CO2 laser and granuloma annulare. (3343416)
1988
47
Octopus bite resulting in granuloma annulare. (3775473)
1986
48
Necrobiosis lipoidica and granuloma annulare. (6693593)
1984
49
Sweat gland disturbances in granuloma annulare and necrobiosis lipoidica. (6860561)
1983
50
Miescher's granuloma of the face. A variant of the necrobiosis lipoidica-granuloma annulare spectrum. (4682543)
1973

Genetic Variations for Granuloma Annulare

Expression for genes affiliated with Granuloma Annulare

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Granuloma Annulare

Search GEO for disease gene expression data for Granuloma Annulare.

Pathways for genes affiliated with Granuloma Annulare

Sources:
38NCBI BioSystems Database, 12EMD Millipore, 52QIAGEN
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Pathways related to Granuloma Annulare according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Development PDGF signaling via STATs and NF-kB
Hide members
9.1MMP2, TNF
29.1MMP2, TNF
3
Hide members
9.1MMP2, TNF

Compounds for genes affiliated with Granuloma Annulare

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Granuloma Annulare according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1cilomilast459.5MMP2, TNF
2go 697645 6010.5TNF, MMP2
3ciglitazone45 2910.5MMP2, TNF
48-isoprostane459.4TNF, MMP2
5ns 39845 6010.4MMP2, TNF
6pentoxifylline45 1110.4MMP2, TNF
7melphalan45 1110.4TNF, MMP2
8pioglitazone45 50 29 1112.4MMP2, TNF
9pdtc459.4TNF, MMP2
10procollagen459.4F13A1, MMP2
11sp 60012545 6010.3TNF, MMP2
12atorvastatin45 50 29 11 2413.3MMP2, TNF
13prednisolone45 29 1111.3MMP2, TNF
14hydrocortisone45 2 60 1112.2TNF, MMP2
15rosiglitazone45 50 29 11 2413.2MMP2, TNF
16troglitazone45 29 60 1112.1MMP2, TNF
17herbimycin a45 6010.1MMP2, TNF
18egcg459.0TNF, MMP2
19pd 98,059458.8MMP2, GLI1, TNF
20vegf458.8MMP2, F13A1, TNF
21tgf beta1458.8MMP2, TNF

GO Terms for genes affiliated with Granuloma Annulare

Sources:
16Gene Ontology
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Biological processes related to Granuloma Annulare according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to hypoxiaGO:0016669.1MMP2, TNF
2cellular response to amino acid stimulusGO:0712308.8MMP2, TNF

Products for genes affiliated with Granuloma Annulare

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Sources for Granuloma Annulare

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet