MCID: GRN007
MIFTS: 47

Granuloma Annulare malady

Skin diseases category

Summaries for Granuloma Annulare

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Granuloma annulare is a long-term (chronic) skin disease consisting of a rash with reddish bumps arranged in a circle or ring. last updated: 5/31/2013

MalaCards: Granuloma Annulare, also known as granulome annulare, is related to dermatitis and sarcoma. An important gene associated with Granuloma Annulare is F13A1 (coagulation factor XIII, A1 polypeptide), and among its related pathways are Development PDGF signaling via STATs and NF-kB and amb2 Integrin signaling. The compounds cilomilast and go 6976 have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and thyroid, and related mouse phenotypes are tumorigenesis and respiratory system.

Wikipedia:63 Granuloma annulare is a fairly rare, chronic dermatological autoimmune condition which presents as... more...

Aliases & Classifications for Granuloma Annulare

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8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

granuloma annulare 8 42 44 30 60
granulome annulare 8


External Ids:

Disease Ontology8 DOID:3777
NCIt39 C3470
MeSH34 D016460
ICD1025 L92.0

Related Diseases for Granuloma Annulare

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Granuloma Annulare:



Diseases related to granuloma annulare

Clinical Features for Granuloma Annulare

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Drugs & Therapeutics for Granuloma Annulare

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Granuloma Annulare cell therapies at LifeMap Discovery.

Genetic Tests for Granuloma Annulare

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Anatomical Context for Granuloma Annulare

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32MalaCards
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MalaCards organs/tissues related to Granuloma Annulare:

32
Skin, Bone, Thyroid, B cells, T cells, Breast, Bone marrow, Monocytes, Testes, Prostate, Eye, Endothelial

Animal Models for Granuloma Annulare or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Granuloma Annulare:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.0TNF
2MP:00053887.7MMP2, GLI1, F13A1, TNF

Publications for Granuloma Annulare

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50PubMed
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Articles related to Granuloma Annulare:

(show top 50)    (show all 518)
idTitleAuthorsYear
1
Granuloma annulare as a possible new adverse effect of topiramate. (24168458)
2014
2
Granuloma annulare. (24354230)
2013
3
Successful treatment of disseminated granuloma annulare with oral fumaric acid esters. (23590379)
2013
4
Dermoscopy of necrobiosis lipoidica and granuloma annulare. (23797090)
2013
5
Etiology, diagnosis, and therapeutic management of granuloma annulare: an update. (23696233)
2013
6
Generalized perforating granuloma annulare: case report. (23317488)
2012
7
Granuloma annulare-like eruption associated with B-cell chronic lymphocytic leukemia. (22830642)
2012
8
Granuloma annulare treated with excimer laser. (23198013)
2012
9
Granuloma annulare of the penis - subcutaneous presentation. (21543288)
2011
10
Psoralen and ultraviolet A in the treatment of granuloma annulare. (21392110)
2011
11
Generalized granuloma annulare associated with scabies. (20526174)
2010
12
Interstitial type granuloma annulare associated with SjAPgren's syndrome. (20536658)
2010
13
Patch-type granuloma annulare. (19258237)
2009
14
Scrofuloderma associated with granuloma annulare-like lichen scrofulosorum. (19997700)
2009
15
Granuloma annulare of childhood successfully treated with potent topical corticosteroids previously unresponsive to tacrolimus ointment 0.1%: report of three cases. (19747319)
2009
16
Granuloma annulare detected by positron emission tomography with computed tomography in a diffuse large B cell lymphoma. (19264581)
2009
17
Severe linear form of granuloma annulare along Blaschko's lines preceding the onset of a classical form of granuloma annulare in a child. (17725676)
2007
18
Annular elastolytic giant cell granuloma: a prodromal stage of mid-dermal elastolysis? (17459032)
2007
19
Clearance of generalized papular umbilicated granuloma annulare in a child with bath PUVA therapy. (16445418)
2006
20
Subcutaneous granuloma annulare in a child's palm: a case report. (16443113)
2006
21
Treatment of generalized granuloma annulare with hydroxychloroquine. (16088169)
2005
22
Subcutaneous granuloma annulare of the scalp: a case report and case review. (16438427)
2005
23
Disseminated granuloma annulare--treatment with fumaric acid esters. (15785051)
2005
24
Granuloma annulare in a site of healed herpes zoster: Wolf's isotopic response. (14761138)
2003
25
A case of disseminated granuloma annulare treated with defibrotide: complete clinical remission and progressive hair darkening. (12932269)
2003
26
Subcutaneous granuloma annulare of the scalp in a diabetic child. (12047654)
2002
27
Treatment of disseminated granuloma annulare with fumaric acid esters. (11914154)
2002
28
Granuloma annulare resolved with topical application of imiquimod. (12220291)
2002
29
Anetoderma secondary to generalized granuloma annulare. (10640927)
2000
30
Patch granuloma annulare: clinicopathologic study of 6 patients. (10688710)
2000
31
Successful treatment of generalized granuloma annulare with polyethylene sheet bath PUVA. (10086870)
1999
32
Generalised granuloma annulare successfully treated with PUVA. (10606948)
1999
33
Annular elastolytic giant cell granuloma: sparing of a burn scar and successful treatment with chloroquine. (10233280)
1999
34
Coexisting morphoea and granuloma annulare-are the conditions related? (10233660)
1999
35
Subcutaneous granuloma annulare and IgA-IgG2 deficiency. (9677736)
1998
36
Granuloma annulare: radiographic demonstration of progressive mutilating arthropathy with vanishing bones. (9592904)
1998
37
Precipitating factors and associated diseases in 84 patients with granuloma annulare: a retrospective study. (8993973)
1996
38
Subcutaneous granuloma annulare in a patient with rheumatoid arthritis and diabetes mellitus. (8961588)
1996
39
Ulcerated necrobiosis lipoidica diabeticorum in a patient with a history of generalized granuloma annulare. (7851128)
1994
40
Expression of interstitial collagenase, 92-kDa gelatinase, and tissue inhibitor of metalloproteinases-1 in granuloma annulare and necrobiosis lipoidica diabeticorum. (8382717)
1993
41
Generalized granuloma annulare in a diabetic patient. A case report. (8515374)
1993
42
Knobbly granuloma annulare (GA) of the fingers of a milkman--a possible relationship to his work. (1424266)
1992
43
Granuloma annulare associated with metastatic adenocarcinoma. (2050458)
1991
44
Generalized granuloma annulare: histopathology and immunopathology. Systematic review of 100 cases and comparison with localized granuloma annulare. (2464013)
1989
45
Atypical granuloma annulare in patients with the acquired immunodeficiency syndrome. (2915072)
1989
46
Generalized granuloma annulare in a patient with acquired immunodeficiency syndrome (AIDS) (3155342)
1987
47
Granuloma annulare and amniotic band syndrome. (3789768)
1986
48
Granuloma annulare arising after herpes zoster. (3782519)
1986
49
Defective neutrophil migration in granuloma annulare, necrobiosis lipoidica, and sarcoidosis. (367286)
1979
50
Granuloma annulare and necrobiosis lipoidica treated by jet injector. (1191532)
1975

Genetic Variations for Granuloma Annulare

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Expression for genes affiliated with Granuloma Annulare

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Granuloma Annulare

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Pathways for genes affiliated with Granuloma Annulare

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37NCBI BioSystems Database, 12EMD Millipore, 51QIAGEN
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Pathways related to Granuloma Annulare according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Development PDGF signaling via STATs and NF-kB
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9.1MMP2, TNF
29.1MMP2, TNF
3
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9.1MMP2, TNF

Compounds for genes affiliated with Granuloma Annulare

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Granuloma Annulare according to GeneCards/GeneDecks:

(show all 21)
idCompoundScoreTop Affiliating Genes
1cilomilast449.5MMP2, TNF
2go 697644 5910.5TNF, MMP2
3ciglitazone44 2810.5MMP2, TNF
48-isoprostane449.4TNF, MMP2
5ns 39844 5910.4MMP2, TNF
6pentoxifylline44 1110.4MMP2, TNF
7melphalan44 1110.4TNF, MMP2
8pioglitazone44 49 28 1112.4MMP2, TNF
9pdtc449.4TNF, MMP2
10procollagen449.4F13A1, MMP2
11sp 60012544 5910.3TNF, MMP2
12atorvastatin44 49 28 11 2413.3MMP2, TNF
13prednisolone44 28 1111.3MMP2, TNF
14hydrocortisone44 2 59 1112.2TNF, MMP2
15rosiglitazone44 49 28 11 2413.2MMP2, TNF
16troglitazone44 28 59 1112.1MMP2, TNF
17herbimycin a44 5910.1MMP2, TNF
18egcg449.0TNF, MMP2
19pd 98,059448.8MMP2, GLI1, TNF
20vegf448.8MMP2, F13A1, TNF
21tgf beta1448.8MMP2, TNF

GO Terms for genes affiliated with Granuloma Annulare

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16Gene Ontology
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Biological processes related to Granuloma Annulare according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to hypoxiaGO:0016669.1MMP2, TNF
2cellular response to amino acid stimulusGO:0712308.8MMP2, TNF

Products for genes affiliated with Granuloma Annulare

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Sources for Granuloma Annulare

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet