MCID: GRN007
MIFTS: 44

Granuloma Annulare malady

Rare diseases, Skin diseases categories

Aliases & Classifications for Granuloma Annulare

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Aliases & Descriptions for Granuloma Annulare:

Name: Granuloma Annulare 30 8 42 44 61
 
Granulome Annulare 8


Classifications:



External Ids:

Disease Ontology8 DOID:3777
MeSH33 D016460
NCIt39 C3470
ICD1025 L92.0

Summaries for Granuloma Annulare

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NIH Rare Diseases:42 Granuloma annulare is a long-term (chronic) skin disease consisting of a rash with reddish bumps arranged in a circle or ring. last updated: 5/31/2013

MalaCards based summary: Granuloma Annulare, also known as granulome annulare, is related to arthropathy and sarcoma. An important gene associated with Granuloma Annulare is F13A1 (coagulation factor XIII, A1 polypeptide), and among its related pathways are Proteoglycans in cancer and Colorectal Cancer Metastasis. The compounds cilomilast and go 6976 have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and thyroid, and related mouse phenotypes are reproductive system and tumorigenesis.

Wikipedia:64 Granuloma annulare is a fairly rare, chronic dermatological autoimmune condition which presents as... more...

Related Diseases for Granuloma Annulare

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Graphical network of the top 20 diseases related to Granuloma Annulare:



Diseases related to granuloma annulare

Symptoms for Granuloma Annulare

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Drugs & Therapeutics for Granuloma Annulare

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Drug clinical trials:

Search ClinicalTrials for Granuloma Annulare

Search NIH Clinical Center for Granuloma Annulare

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Granuloma Annulare cell therapies at LifeMap Discovery.

Genetic Tests for Granuloma Annulare

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Anatomical Context for Granuloma Annulare

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MalaCards organs/tissues related to Granuloma Annulare:

31
Skin, Bone, Thyroid, B cells, T cells, Breast, Neutrophil, Bone marrow, Eye, Testes, Monocytes, Endothelial

Animal Models for Granuloma Annulare or affiliated genes

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MGI Mouse Phenotypes related to Granuloma Annulare:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.8GLI1, TNF, F13A1
2MP:00020068.4GLI1, MMP2, TNF
3MP:00053888.0GLI1, MMP2, TNF, F13A1
4MP:00107687.7F13A1, TNF, MMP2, GLI1

Publications for Granuloma Annulare

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Articles related to Granuloma Annulare:

(show top 50)    (show all 536)
idTitleAuthorsYear
1
Granulomatous dysimmune reactions (sarcoidosis, granuloma annulare, and others) on differently injured skin areas. (25160106)
2014
2
Evolution of granuloma annulare to mid-dermal elastolysis: report of a case and review of the literature. (24447045)
2014
3
Necrobiotic granuloma annulare of the penis: a case responding to anti-tuberculosis therapy with a review of the literature. (25201475)
2014
4
Residents'corner February 2014. DeRmpath & Clinic: differential diagnosis in palisading non-infectious granulomas. Diagnosis: Case 1: Granuloma annulare. Case 2: Necrobiosis lipoidica. (24691245)
2014
5
Granuloma annulare-like palisading as a histological reaction to a tattoo. (25201856)
2014
6
Dendritic cells are prominent in granuloma annulare. (25437969)
2014
7
Generalized granuloma annulare presenting with lesions resembling eruptive xanthoma. (23720988)
2013
8
Periocular Granuloma Annulare: A Case Report and Review of Literature. (23551387)
2013
9
Treatment of disseminated granuloma annulare with oral vitamin E: 'primum nil nocere'. (23988344)
2013
10
Localized interstitial granuloma annulare induced by subcutaneous injections for desensitization. (24011321)
2013
11
Generalized perforating granuloma annulare: case report. (23317488)
2012
12
Granuloma annulare within the red dye of a tattoo. (22126139)
2012
13
An unusual presentation of subcutaneous granuloma annulare in association with juvenile-onset diabetes: case report and literature review. (22085091)
2012
14
Granuloma annulare of the penis - subcutaneous presentation. (21543288)
2011
15
Generalized granuloma annulare possibly associated with acute Epstein-Barr virus infection. (21697070)
2011
16
Generalized granuloma annulare in a photosensitive distribution resolving with scarring and milia formation. (19438575)
2009
17
A case of atypical granuloma annulare involving both ears. (20523836)
2009
18
Granuloma annulare resolving with features of mid-dermal elastolysis. (20055825)
2009
19
Patch-type granuloma annulare. (19258237)
2009
20
Successful treatment of perforating granuloma annulare with 0.1% tacrolimus ointment. (18608717)
2008
21
Photo quiz. Case 8. Granuloma annulare. (18193512)
2007
22
Histological and immunohistochemical study of granuloma annulare and subcutaneous granuloma annulare in children. (17448194)
2007
23
Generalized interstitial granuloma annulare induced by pegylated interferon-alpha. (17033180)
2006
24
Disseminated granuloma annulare associated with chronic myelogenous leukemia. (12928535)
2003
25
Generalized perforating granuloma annulare in an infant. (12657009)
2003
26
An unusual presentation of diffuse granuloma annulare in an HIV-positive patient - immunohistochemical evidence of predominant CD8 lymphocytes. (12072009)
2002
27
Multiple lesions of granuloma annulare following BCG vaccination: case report and review of the literature. (11737453)
2001
28
Lymphoepithelioid cell lymphoma (Lennert's lymphoma) presenting as atypical granuloma annulare. (10792231)
2000
29
Granuloma annulare. (10951648)
2000
30
Anetoderma secondary to generalized granuloma annulare. (10640927)
2000
31
Penile granuloma annulare. (10448398)
1999
32
Localized granuloma annulare in children: a review of 42 cases. (10486097)
1999
33
Seasonally recurrent granuloma annulare on sun-exposed areas. (10468828)
1999
34
Generalized perforating granuloma annulare. (10565634)
1999
35
Subcutaneous granuloma annulare: radiologic appearance. (9638837)
1998
36
Follicular pustulous granuloma annulare. (9747379)
1998
37
Generalized granuloma annulare, mononucleosis, and positive rheumatoid factor. (7896487)
1995
38
Ichthyosis. Basal cell carcinoma. Granuloma annulare. Self-assessment examination of the American Academy of Dermatology. (8277025)
1994
39
Localized granuloma annulare. Histopathological and direct immunofluorescence study of early lesions, and the adjacent normal-looking skin of actively spreading lesions. (8311184)
1993
40
Familial granuloma annulare. (1358835)
1992
41
Granuloma annulare arising after herpes zoster. (1399211)
1992
42
Granuloma annulare and disseminated herpes zoster. (1737692)
1992
43
Granuloma annulare associated with metastatic adenocarcinoma. (2050458)
1991
44
Granuloma annulare temporally associated with carcinoma of the breast. (2768584)
1989
45
Granuloma annulare of the buccal mucosa in association with AIDS. (2648243)
1989
46
Generalized granuloma annulare: clinical and laboratory findings in 100 patients. (2913080)
1989
47
Monocyte-modulating activities in the sera of patients with granuloma annulare. (3053834)
1988
48
Topical vitamin E in granuloma annulare. (3391733)
1988
49
Granuloma annulare-like skin lesion due to Fusarium roseum: therapy with ketoconazole. (3813589)
1987
50
Granuloma annulare, rheumatoid nodules and necrobiosis lipoidica. (884054)
1977

Variations for Granuloma Annulare

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Expression for genes affiliated with Granuloma Annulare

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Search GEO for disease gene expression data for Granuloma Annulare.

Pathways for genes affiliated with Granuloma Annulare

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Pathways related to Granuloma Annulare according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1MMP2, TNF
29.1TNF, MMP2
3
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
9.1MMP2, TNF
49.1MMP2, TNF
5
Show member pathways
9.1MMP2, TNF
69.0GLI1, MMP2

Compounds for genes affiliated with Granuloma Annulare

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Compounds related to Granuloma Annulare according to GeneCards Suite gene sharing:

(show all 29)
idCompoundScoreTop Affiliating Genes
1cilomilast449.5TNF, MMP2
2go 697644 6010.5TNF, MMP2
3ciglitazone44 2810.5MMP2, TNF
48-isoprostane449.5MMP2, TNF
5ns 39844 6010.5TNF, MMP2
6ivig449.5TNF, MMP2
7pentoxifylline44 1110.5TNF, MMP2
8melphalan44 50 1111.5MMP2, TNF
9pioglitazone28 44 50 1112.5TNF, MMP2
10procollagen449.5F13A1, MMP2
11pdtc449.4MMP2, TNF
12sp 60012544 6010.4TNF, MMP2
13atorvastatin44 50 28 24 1113.4TNF, MMP2
14prednisolone44 28 1111.4MMP2, TNF
15hydrocortisone44 1 60 1112.4MMP2, TNF
16rosiglitazone28 44 50 24 1113.4TNF, MMP2
17troglitazone44 28 60 1112.4MMP2, TNF
18egcg449.4TNF, MMP2
19tgf beta1449.3MMP2, TNF
20herbimycin a44 6010.3TNF, MMP2
21curcumin449.3MMP2, TNF
22aspirin44 50 28 2412.2MMP2, F13A1
23methotrexate50 44 1111.2TNF, MMP2
24fibrinogen449.1F13A1, TNF
25n acetylcysteine449.1MMP2, TNF
26ly294002449.1TNF, MMP2
27sb 20358044 6010.0TNF, MMP2
28vegf448.9TNF, MMP2, F13A1
29pd 98,059448.9TNF, MMP2, GLI1

GO Terms for genes affiliated with Granuloma Annulare

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Cellular components related to Granuloma Annulare according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.6MMP2, TNF, F13A1

Biological processes related to Granuloma Annulare according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:00301989.1MMP2, TNF
2cellular response to amino acid stimulusGO:00712309.0MMP2, TNF
3response to hypoxiaGO:00016668.8MMP2, TNF

Molecular functions related to Granuloma Annulare according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1transcription regulatory region DNA bindingGO:00442129.3GLI1, TNF

Sources for Granuloma Annulare

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet