MCID: GRN007
MIFTS: 52

Granuloma Annulare malady

Rare diseases, Skin diseases categories
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Summaries for Granuloma Annulare

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Sources:
43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Granuloma annulare is a long-term (chronic) skin disease consisting of a rash with reddish bumps arranged in a circle or ring. last updated: 5/31/2013

MalaCards: Granuloma Annulare, also known as granulome annulare, is related to sarcoma and arthropathy. An important gene associated with Granuloma Annulare is F13A1 (coagulation factor XIII, A1 polypeptide), and among its related pathways are Proteoglycans in cancer and Colorectal Cancer Metastasis. The compounds cilomilast and go 6976 have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and thyroid, and related mouse phenotypes are reproductive system and tumorigenesis.

Wikipedia:65 Granuloma annulare is a fairly rare, chronic dermatological autoimmune condition which presents as... more...

Aliases & Classifications for Granuloma Annulare

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8Disease Ontology, 43NIH Rare Diseases, 45Novoseek, 31LifeMap Discovery™, 62UMLS, 35MeSH, 58SNOMED-CT, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases


Aliases & Descriptions:

granuloma annulare 8 43 45 31 62
granulome annulare 8


External Ids:

Disease Ontology8 DOID:3777
MeSH35 D016460
NCIt40 C3470
ICD1025 L92.0

Related Diseases for Granuloma Annulare

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Granuloma Annulare:



Diseases related to granuloma annulare

Symptoms for Granuloma Annulare

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Drugs & Therapeutics for Granuloma Annulare

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Granuloma Annulare

Search NIH Clinical Center for Granuloma Annulare

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Granuloma Annulare cell therapies at LifeMap Discovery.

Genetic Tests for Granuloma Annulare

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Anatomical Context for Granuloma Annulare

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33MalaCards
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MalaCards organs/tissues related to Granuloma Annulare:

33
Skin, Bone, Thyroid, B cells, T cells, Breast, Bone marrow, Monocytes, Testes, Prostate, Eye, Endothelial

Animal Models for Granuloma Annulare or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Granuloma Annulare:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053898.8GLI1, TNF, F13A1
2MP:00020068.4GLI1, MMP2, TNF
3MP:00053888.0GLI1, MMP2, TNF, F13A1
4MP:00107687.7F13A1, TNF, MMP2, GLI1

Publications for Granuloma Annulare

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52PubMed
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Articles related to Granuloma Annulare:

(show top 50)    (show all 509)
idTitleAuthorsYear
1
Generalized granuloma annulare presenting with lesions resembling eruptive xanthoma. (23720988)
2013
2
Periocular Granuloma Annulare: A Case Report and Review of Literature. (23551387)
2013
3
Treatment of disseminated granuloma annulare with oral vitamin E: 'primum nil nocere'. (23988344)
2013
4
Localized interstitial granuloma annulare induced by subcutaneous injections for desensitization. (24011321)
2013
5
Generalized perforating granuloma annulare: case report. (23317488)
2012
6
Granuloma annulare within the red dye of a tattoo. (22126139)
2012
7
An unusual presentation of subcutaneous granuloma annulare in association with juvenile-onset diabetes: case report and literature review. (22085091)
2012
8
Granuloma annulare of the penis - subcutaneous presentation. (21543288)
2011
9
Generalized granuloma annulare possibly associated with acute Epstein-Barr virus infection. (21697070)
2011
10
Granuloma annulare. (20209383)
2010
11
Generalized granuloma annulare in a photosensitive distribution resolving with scarring and milia formation. (19438575)
2009
12
A case of atypical granuloma annulare involving both ears. (20523836)
2009
13
Granuloma annulare resolving with features of mid-dermal elastolysis. (20055825)
2009
14
Patch-type granuloma annulare. (19258237)
2009
15
Eruptive xanthoma with unexpected granuloma annulare-like microscopic appearance: case report. (19668945)
2009
16
Successful treatment of perforating granuloma annulare with 0.1% tacrolimus ointment. (18608717)
2008
17
Photo quiz. Case 8. Granuloma annulare. (18193512)
2007
18
Histological and immunohistochemical study of granuloma annulare and subcutaneous granuloma annulare in children. (17448194)
2007
19
Generalized interstitial granuloma annulare induced by pegylated interferon-alpha. (17033180)
2006
20
Disseminated granuloma annulare associated with chronic myelogenous leukemia. (12928535)
2003
21
Generalized perforating granuloma annulare in an infant. (12657009)
2003
22
Pustular generalized perforating granuloma annulare. (14616383)
2003
23
An unusual presentation of diffuse granuloma annulare in an HIV-positive patient - immunohistochemical evidence of predominant CD8 lymphocytes. (12072009)
2002
24
Multiple lesions of granuloma annulare following BCG vaccination: case report and review of the literature. (11737453)
2001
25
Association between zalcitabine therapy for human immunodeficiency virus and granuloma annulare? (11453824)
2001
26
Lymphoepithelioid cell lymphoma (Lennert's lymphoma) presenting as atypical granuloma annulare. (10792231)
2000
27
Granuloma annulare. (10951648)
2000
28
Anetoderma secondary to generalized granuloma annulare. (10640927)
2000
29
Penile granuloma annulare. (10448398)
1999
30
Localized granuloma annulare in children: a review of 42 cases. (10486097)
1999
31
Seasonally recurrent granuloma annulare on sun-exposed areas. (10468828)
1999
32
Generalized perforating granuloma annulare. (10565634)
1999
33
Subcutaneous granuloma annulare: radiologic appearance. (9638837)
1998
34
Follicular pustulous granuloma annulare. (9747379)
1998
35
Precipitating factors and associated diseases in 84 patients with granuloma annulare: a retrospective study. (8993973)
1996
36
Generalized granuloma annulare, mononucleosis, and positive rheumatoid factor. (7896487)
1995
37
Ichthyosis. Basal cell carcinoma. Granuloma annulare. Self-assessment examination of the American Academy of Dermatology. (8277025)
1994
38
Localized granuloma annulare. Histopathological and direct immunofluorescence study of early lesions, and the adjacent normal-looking skin of actively spreading lesions. (8311184)
1993
39
Familial granuloma annulare. (1358835)
1992
40
Granuloma annulare arising after herpes zoster. (1399211)
1992
41
Granuloma annulare and disseminated herpes zoster. (1737692)
1992
42
Granuloma annulare associated with metastatic adenocarcinoma. (2050458)
1991
43
Granuloma annulare temporally associated with carcinoma of the breast. (2768584)
1989
44
Granuloma annulare of the buccal mucosa in association with AIDS. (2648243)
1989
45
Generalized granuloma annulare: clinical and laboratory findings in 100 patients. (2913080)
1989
46
Monocyte-modulating activities in the sera of patients with granuloma annulare. (3053834)
1988
47
Topical vitamin E in granuloma annulare. (3391733)
1988
48
Granuloma annulare-like skin lesion due to Fusarium roseum: therapy with ketoconazole. (3813589)
1987
49
Visceral and skin granuloma annulare, diabetes, and polyendocrine disease. (3094761)
1986
50
Granuloma annulare, rheumatoid nodules and necrobiosis lipoidica. (884054)
1977

Variations for Granuloma Annulare

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Expression for genes affiliated with Granuloma Annulare

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Granuloma Annulare

Search GEO for disease gene expression data for Granuloma Annulare.

Pathways for genes affiliated with Granuloma Annulare

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50PathCards, 30KEGG, 53QIAGEN, 60Thomson Reuters, 38NCBI BioSystems Database, 55Reactome
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Pathways related to Granuloma Annulare according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1MMP2, TNF
29.1TNF, MMP2
3
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.1MMP2, TNF
49.1MMP2, TNF
5
Show member pathways
9.1MMP2, TNF
69.0GLI1, MMP2

Compounds for genes affiliated with Granuloma Annulare

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45Novoseek, 61Tocris Bioscience, 29IUPHAR, 11DrugBank, 51PharmGKB, 24HMDB, 3BitterDB
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Compounds related to Granuloma Annulare according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1cilomilast459.5MMP2, TNF
2go 697645 6110.5MMP2, TNF
3ciglitazone45 2910.5TNF, MMP2
48-isoprostane459.5MMP2, TNF
5ns 39845 6110.5MMP2, TNF
6ivig459.5MMP2, TNF
7pentoxifylline45 1110.5TNF, MMP2
8melphalan45 51 1111.5MMP2, TNF
9pioglitazone29 45 51 1112.5MMP2, TNF
10pdtc459.5TNF, MMP2
11procollagen459.4F13A1, MMP2
12sp 60012545 6110.4MMP2, TNF
13atorvastatin45 51 29 24 1113.4TNF, MMP2
14prednisolone45 29 1111.4TNF, MMP2
15hydrocortisone45 3 61 1112.4MMP2, TNF
16rosiglitazone29 45 51 24 1113.4MMP2, TNF
17troglitazone45 29 61 1112.4TNF, MMP2
18egcg459.4MMP2, TNF
19tgf beta1459.3MMP2, TNF
20herbimycin a45 6110.3MMP2, TNF
21curcumin459.3TNF, MMP2
22aspirin45 51 29 2412.2MMP2, F13A1
23methotrexate51 45 1111.2MMP2, TNF
24fibrinogen459.1TNF, F13A1
25n acetylcysteine459.1TNF, MMP2
26ly294002459.1MMP2, TNF
27sb 20358045 6110.0MMP2, TNF
28vegf458.9F13A1, TNF, MMP2
29pd 98,059458.9GLI1, MMP2, TNF

GO Terms for genes affiliated with Granuloma Annulare

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16Gene Ontology
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Cellular components related to Granuloma Annulare according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.6MMP2, TNF, F13A1

Biological processes related to Granuloma Annulare according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:0301989.1MMP2, TNF
2cellular response to amino acid stimulusGO:0712309.0MMP2, TNF
3response to hypoxiaGO:0016668.8MMP2, TNF

Molecular functions related to Granuloma Annulare according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transcription regulatory region DNA bindingGO:0442129.3GLI1, TNF

Products for genes affiliated with Granuloma Annulare

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Sources for Granuloma Annulare

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet