MCID: GRN005
MIFTS: 35

Granuloma Inguinale malady

Infectious category

Summaries for Granuloma Inguinale

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A primary bacterial infectious disease that results in infection located in skin or located in mucosa of genital tract, has material basis in klebsiella granulomatis, transmitted by sexual contact or transmitted by contact with the open sores. the infection has symptom painless genital ulcers.

MalaCards: Granuloma Inguinale, also known as donovanosis, is related to lymphogranuloma venereum and chancroid, and has symptoms including painless genital ulcers An important gene associated with Granuloma Inguinale is NRIP1 (nuclear receptor interacting protein 1). The compounds testosterone and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include skin or, skin and spinal cord.

Wikipedia:64 Granuloma inguinale is a bacterial disease caused by Klebsiella granulomatis characterized by ulcerative... more...

Aliases & Classifications for Granuloma Inguinale

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 61UMLS, 40NCIt, 27ICD9CM, 35MeSH, 57SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

granuloma inguinale 8 43 10 61
donovanosis 8 43
pudendal ulcer 8


External Ids:

Disease Ontology8 DOID:9113
NCIt40 C3065
ICD9CM27 099.2
SNOMED-CT57 186947000, 28867007
MeSH35 D006100
ICD1025 A58

Related Diseases for Granuloma Inguinale

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Granuloma Inguinale via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 13)
idRelated DiseaseScoreTop Affiliating Genes
1lymphogranuloma venereum10.8
2chancroid10.8
3gonorrhea10.4
4syphilis10.4
5squamous cell carcinoma10.3
6myoblastoma10.2
7mucinous adenocarcinoma10.2
8adenocarcinoma10.2
9vaginitis10.2
10vulva squamous cell carcinoma10.2
11splenomegaly10.2
12infertility10.0NRIP1
13down syndrome10.0NRIP1

Graphical network of diseases related to Granuloma Inguinale:



Diseases related to granuloma inguinale

Clinical Features for Granuloma Inguinale

Sources:
8Disease Ontology
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Symptoms:

8
  • painless genital ulcers

Drugs & Therapeutics for Granuloma Inguinale

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Granuloma Inguinale

Drug clinical trials:

Search ClinicalTrials for Granuloma Inguinale

Search NIH Clinical Center for Granuloma Inguinale

Search CenterWatch for Granuloma Inguinale

Genetic Tests for Granuloma Inguinale

Anatomical Context for Granuloma Inguinale

Sources:
33MalaCards, 14FMA
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MalaCards organs/tissues related to Granuloma Inguinale:

33
Skin, Spinal cord, Lymph node, Uterus, Cervix

FMA organs/tissues related to Granuloma Inguinale:

14
Skin or

Animal Models for Granuloma Inguinale or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Granuloma Inguinale

Sources:
51PubMed
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Articles related to Granuloma Inguinale:

(show top 50)    (show all 262)
idTitleAuthorsYear
1
Granuloma inguinale (donovanosis) presenting as a neck mass in an infant. (10079347)
1999
2
Disseminated granuloma inguinale secondary to cervical infection. (9515686)
1998
3
Granuloma inguinale and HIV: a unique presentation and novel treatment regimen. (9308572)
1997
4
Granuloma inguinale: first case reported in the last four decades in China. (8891837)
1996
5
Nongenital granuloma inguinale in an oncology patient. (8092122)
1994
6
Donovanosis (granuloma inguinale) still exists. (1634289)
1992
7
A serological test for granuloma inguinale. (1398665)
1992
8
The diagnosis and treatment of donovanosis (granuloma inguinale). (1774048)
1991
9
Diagnosis of an unusual abdominal presentation of granuloma inguinale by fine needle aspiration cytology. (2375227)
1990
10
A clinicopathological study of granuloma inguinale in Barbados. (3247729)
1988
11
Granuloma inguinale (donovanosis) in women. (3172077)
1988
12
Granuloma inguinale (donovanosis) of the oral cavity. A case report. (3877995)
1985
13
Extragenital granuloma inguinale (Donovanosis) diagnosed in the United Kingdom: a clinical, histological, and electron microscopical study. (6470171)
1984
14
Chancroid and granuloma inguinale. (6687703)
1983
15
Vaginal bleeding in granuloma inguinale. Case reports. (7082983)
1982
16
Sclerosing granuloma inguinale. (6972244)
1981
17
Granuloma inguinale with several unique features. (1062702)
1976
18
Donovanosis (granuloma inguinale): a rare cause of osteolytic bone lesions. (5417241)
1970
19
Granuloma inguinale. A clinical, histological and ultrastructural study. (4188533)
1970
20
Granuloma inguinale. (5695878)
1968
21
Studies on granuloma inguinale. V. Isolation of a bacterium resembling Donovania granulomatis from the faeces of a patient with granuloma inguinale. (13899699)
1962
22
Granuloma inguinale (venereum). (13364369)
1956
23
Anorectocolonic involvement in lymphogranuloma venereum and granuloma inguinale; some surgical aspects. (13267722)
1955
24
Studies on granuloma inguinale. II. The complement fixation test in the diagnosis of granuloma inguinale. (13016908)
1953
25
Granuloma inguinale associated with hepato-splenomegaly and diffuse pulmonary infiltration. (12996482)
1952
26
Intramuscular chloramphenicol in the treatment of gonorrhea and granuloma inguinale. (14924078)
1952
27
Granuloma inguinale; carcinoma? (14810212)
1951
28
Terramycin in the treatment of chancroid, lymphogranuloma venereum, and granuloma inguinale. (14878094)
1951
29
Nine cases of granuloma inguinale treated with chloromycetin. (14838254)
1951
30
Squamous cell carcinoma simulating granuloma inguinale. (14770485)
1950
31
Granuloma inguinale of the cervix uteri and vulva treated with streptomycin. (14771195)
1950
32
Streptomycin therapy in granuloma inguinale. (15407931)
1949
33
Streptomycin therapy of granuloma inguinale. (18129459)
1949
34
Anorectogenital lymphogranuloma venereum and granuloma inguinale treated with aureomycin. (18136343)
1949
35
Granuloma inguinale. (18113380)
1949
36
Diagnostic tests in granuloma inguinale. (18129460)
1949
37
Oral aureomycin in the therapy of granuloma inguinale. (15393653)
1949
38
Streptomycin therapy of chronic granuloma inguinale. (18110578)
1949
39
GRANULOMA INGUINALE. (18731381)
1948
40
The treatment of granuloma inguinale with streptomycin. (18902199)
1948
41
Effects of a new trivalent antimony compound upon granuloma inguinale. (18908436)
1948
42
Diagnosis and treatment of chancroid, lymphopathia venereum, and granuloma inguinale. (20293100)
1947
43
Notes on the epidemiology of granuloma inguinale. (20258817)
1947
44
Granuloma inguinale treated with streptomycin; report of three cases. (20251554)
1947
45
Chancroid; granuloma inguinale; clinical and laboratory aspects epidemiology, and treatment. (20292085)
1945
46
The Initial Lesion of Granuloma Inguinale: Report of a Case. (20893017)
1941
47
Granuloma Inguinale. (19987974)
1931
48
GRANULOMA INGUINALE: ITS PRESENCE IN CANADA. (20318046)
1930
49
Granuloma Inguinale Tropicum. (18735895)
1913
50
Case of (?) Granuloma Inguinale. (19974966)
1911

Genetic Variations for Granuloma Inguinale

Expression for genes affiliated with Granuloma Inguinale

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Granuloma Inguinale

Search GEO for disease gene expression data for Granuloma Inguinale.

Pathways for genes affiliated with Granuloma Inguinale

Compounds for genes affiliated with Granuloma Inguinale

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 24HMDB
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Compounds related to Granuloma Inguinale according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1testosterone45 60 11 2412.1NRIP1, WT1
2retinoic acid45 2410.1NRIP1, WT1
3steroid459.0NRIP1, WT1
4estrogen458.8NRIP1, WT1

GO Terms for genes affiliated with Granuloma Inguinale

Sources:
16Gene Ontology
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Biological processes related to Granuloma Inguinale according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of transcription from RNA polymerase II promoterGO:0001229.1NRIP1, WT1
2positive regulation of transcription, DNA-dependentGO:0458938.8NRIP1, WT1

Products for genes affiliated with Granuloma Inguinale

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Granuloma Inguinale

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet