MCID: GRN005
MIFTS: 37

Granuloma Inguinale malady

Categories: Rare diseases, Infectious diseases, Skin diseases

Aliases & Classifications for Granuloma Inguinale

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Aliases & Descriptions for Granuloma Inguinale:

Name: Granuloma Inguinale 10 45 12 36 65
Donovanosis 10 45
 
Pudendal Ulcer 10

Classifications:



External Ids:

Disease Ontology10 DOID:9113
ICD1027 A58
ICD9CM29 099.2
SNOMED-CT59 186947000, 28867007
MeSH36 D006100
NCIt42 C3065
UMLS65 C0018190

Summaries for Granuloma Inguinale

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Disease Ontology:10 A primary bacterial infectious disease that results in infection located in skin or located in mucosa of genital tract, has material basis in Klebsiella granulomatis, transmitted by sexual contact or transmitted by contact with the open sores. The infection has symptom painless genital ulcers.

MalaCards based summary: Granuloma Inguinale, also known as donovanosis, is related to amyloidosis and leukemia, and has symptoms including painless genital ulcers An important gene associated with Granuloma Inguinale is NRIP1 (Nuclear Receptor Interacting Protein 1), and among its related pathways are and Integrated Pancreatic Cancer Pathway. Affiliated tissues include skin or, skin and bone, and related mouse phenotypes are mortality/aging and cellular.

Wikipedia:68 Granuloma inguinale (also known as donovanosis) is a bacterial disease caused by Klebsiella granulomatis... more...

Related Diseases for Granuloma Inguinale

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Graphical network of the top 20 diseases related to Granuloma Inguinale:



Diseases related to granuloma inguinale

Symptoms for Granuloma Inguinale

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Symptoms:

 10
  • painless genital ulcers

Drugs & Therapeutics for Granuloma Inguinale

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Granuloma Inguinale


Cochrane evidence based reviews: granuloma inguinale

Genetic Tests for Granuloma Inguinale

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Anatomical Context for Granuloma Inguinale

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MalaCards organs/tissues related to Granuloma Inguinale:

33
Skin, Bone, Brain, T cells, Liver, Bone marrow, Lung

FMA organs/tissues related to Granuloma Inguinale:

16
Skin or

Animal Models for Granuloma Inguinale or affiliated genes

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MGI Mouse Phenotypes related to Granuloma Inguinale:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.0C3, CD22, CD4, NRIP1, ST8SIA4, TBP
2MP:00053846.8ABCG2, C3, CD22, CD4, NRIP1, ST8SIA4

Publications for Granuloma Inguinale

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Articles related to Granuloma Inguinale:

(show top 50)    (show all 264)
idTitleAuthorsYear
1
The neutrophil to lymphocyte ratio is associated with severity of rheumatic mitral valve stenosis. (25999773)
2015
2
Dissociated word production and comprehension in semantic dementia. (25987438)
2015
3
Selenium metabolism to the trimethylselenonium ion (TMSe) varies markedly because of polymorphisms in the indolethylamine N-methyltransferase gene. (26537946)
2015
4
Allergenic Can f 1 and its human homologue Lcn-1 direct dendritic cells to induce divergent immune responses. (26218644)
2015
5
MoGAT-2 Inhibitors May Provide Effective Treatment for Hypertriglyceridemia. (25147598)
2014
6
Surgical advances for extracranial carotid stenosis. (24402497)
2014
7
Isolated Gastrocnemius Recession for Treatment of Insertional Achilles Tendinopathy: A Pilot Study. (25389232)
2014
8
Alteration of plasma phospholipid fatty acid profile in patients with septic shock. (23954620)
2013
9
ES micro-environment enhances stemness and inhibits apoptosis in human limbal stem cells via the maintenance of telomerase activity. (23326460)
2013
10
R31C GNRH1 mutation and congenital hypogonadotropic hypogonadism. (23936060)
2013
11
Effects of transcription factor T-bet, GATA-3, FoxP3 and CD4(+)CD25(+)regulatory T cells in pathogenesis of child Hench-Schonlein purpura]. (22391183)
2012
12
Fifteen pressure ulcers presenting in a known paediatric case of histiocytoma of the spine. (22885309)
2012
13
Primary resection of Kommerell diverticulum and left subclavian artery transfer. (22884596)
2012
14
Barrett's esophagus. Practical issues for daily routine diagnosis. (22513275)
2012
15
Periarticular diffuse neurofibroma of the upper limb. (22203949)
2011
16
Inhibition of beta-secretase in vivo via antibody binding to unique loops (D and F) of BACE1. (21209097)
2011
17
Prevention of diabetes in hypertensive patients: results and implications from the VALUE trial. (19475773)
2009
18
Differential and synergistic effect of nerve growth factor and cAMP on the regulation of early response genes during neuronal differentiation. (19176979)
2009
19
Potential contribution of naA^ve immune effectors to oral tumor resistance: role in synergistic induction of VEGF, IL-6, and IL-8 secretion. (17703300)
2008
20
Abatacept modulates human dendritic cell-stimulated T-cell proliferation and effector function independent of IDO induction. (17945538)
2008
21
Long-range enhancers are required to maintain expression of the autoantigen islet-specific glucose-6-phosphatase catalytic subunit-related protein in adult mouse islets in vivo. (17942825)
2008
22
Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis. (18997785)
2008
23
An unexpected new role of mutant Ras: perturbation of human embryonic development. (17211612)
2007
24
Conditional mutagenesis reveals immunological functions of widely expressed genes: activation thresholds, homeostatic mechanisms and disease models. (17203660)
2007
25
How does current care practice influence the experience of a new diagnosis of motor neuron disease? A qualitative study of current guidelines-based practice. (16963405)
2006
26
Histone deacetylase 3 represses p15(INK4b) and p21(WAF1/cip1) transcription by interacting with Sp1. (16298343)
2006
27
Clinical presentation of melioidosis in Queensland, Australia. (16111729)
2005
28
Systemic lupus erythematosus induced by anti-tumour necrosis factor alpha therapy: a French national survey. (15899041)
2005
29
Glutathione depletion resulting in selective mitochondrial complex I inhibition in dopaminergic cells is via an NO-mediated pathway not involving peroxynitrite: implications for Parkinson's disease. (15715660)
2005
30
The role of angiotensin receptor blockers and/or angiotensin converting enzyme inhibitors in the prevention of atrial fibrillation in patients with cardiovascular diseases: meta-analysis of randomized controlled clinical trials. (15511250)
2004
31
Transcription factor Egr-1 in calcific aortic valve disease. (15597579)
2004
32
Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins/hypocretins. (12514194)
2003
33
A novel human nicotinic receptor subunit, alpha10, that confers functionality to the alpha9-subunit. (11752216)
2002
34
Lack of association of a single-nucleotide polymorphism of the mu-opioid receptor gene with anxiety-related traits: results from a cross-sectional study of adults and a longitudinal study of children. (12210283)
2002
35
Absence of deafness-associated connexin-26 (GJB2) gene mutations in the Omani population. (11748849)
2001
36
Thrombopoietin in thrombocytopenias of childhood. (11446655)
2001
37
A novel enhancer of insulinotrophic action by high glucose (JTT-608) stimulates insulin secretion from pancreatic beta-cells via a new cellular mechanism. (11356916)
2001
38
Effect of human plasma-type platelet-activating factor acetylhydrolase in two anaphylactic shock models. (10708725)
2000
39
RET/PTC activation in hyalinizing trabecular tumors of the thyroid. (11117781)
2000
40
Advanced glycation end products in Alzheimer's disease and other neurodegenerative diseases. (9777946)
1998
41
Tamoxifen for retroperitoneal fibrosis. (9497980)
1997
42
Hyaluronidase enhancement of TNF-mediated cell death is reversed by TGF-beta 1. (9435505)
1997
43
Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization. (9133646)
1997
44
Peptidergic innervation of the human gallbladder. (8740928)
1996
45
Sequential chemotherapy and immunotherapy for the treatment of metastatic melanoma. (1477078)
1992
46
M1 and M2 muscarinic receptors mediate excitation and inhibition of guinea-pig intracardiac neurones in culture. (2352188)
1990
47
Experimental encephalitozoonosis in neonatal dogs. (3107200)
1987
48
Embryonal rhabdomyosarcoma of the prostatic-urethral region in an adult. (3986467)
1985
49
Letter: Hiatus hernia and competence of gastro-oesophageal sphincter. (4434153)
1974
50
Clinical investigation of paragonimiasis. (13726121)
1960

Variations for Granuloma Inguinale

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Expression for genes affiliated with Granuloma Inguinale

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Search GEO for disease gene expression data for Granuloma Inguinale.

Pathways for genes affiliated with Granuloma Inguinale

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Pathways related to Granuloma Inguinale according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.8
29.3RRM1, TBP, WT1
39.2CD22, CD4

GO Terms for genes affiliated with Granuloma Inguinale

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Sources for Granuloma Inguinale

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet