MCID: GRN005
MIFTS: 37

Granuloma Inguinale malady

Infectious diseases category

Summaries for Granuloma Inguinale

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A primary bacterial infectious disease that results in infection located in skin or located in mucosa of genital tract, has material basis in klebsiella granulomatis, transmitted by sexual contact or transmitted by contact with the open sores. the infection has symptom painless genital ulcers.

MalaCards: Granuloma Inguinale, also known as donovanosis, is related to lymphogranuloma venereum and chancroid, and has symptoms including painless genital ulcers An important gene associated with Granuloma Inguinale is NRIP1 (nuclear receptor interacting protein 1). The compounds testosterone and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include skin or, skin and cervix.

Wikipedia:63 Granuloma inguinale is a bacterial disease caused by Klebsiella granulomatis characterized by ulcerative... more...

Aliases & Classifications for Granuloma Inguinale

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 39NCIt, 27ICD9CM, 34MeSH, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

granuloma inguinale 8 42 10 60
donovanosis 8 42
pudendal ulcer 8


External Ids:

Disease Ontology8 DOID:9113
NCIt39 C3065
ICD9CM27 099.2
SNOMED-CT56 186947000, 28867007
MeSH34 D006100
ICD1025 A58

Related Diseases for Granuloma Inguinale

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17GeneCards, 18GeneDecks
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Diseases related to Granuloma Inguinale via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 21)
idRelated DiseaseScoreTop Affiliating Genes
1lymphogranuloma venereum10.8
2chancroid10.7
3gonorrhea10.4
4cervicitis10.4
5syphilis10.4
6squamous cell carcinoma10.3
7vaginitis10.3
8endocervicitis10.1
9myoblastoma10.1
10orbital granuloma10.1
11mucinous adenocarcinoma10.1
12adenocarcinoma10.1
13lymphadenitis10.1
14osteomyelitis10.1
15otitis media10.1
16vulva squamous cell carcinoma10.1
17elephantiasis10.1
18infertility10.0NRIP1
19down syndrome10.0NRIP1
20hairy cell leukemia10.0
21leukemia10.0

Graphical network of the top 20 diseases related to Granuloma Inguinale:



Diseases related to granuloma inguinale

Clinical Features for Granuloma Inguinale

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8Disease Ontology
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Symptoms:

8
  • painless genital ulcers

Drugs & Therapeutics for Granuloma Inguinale

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Granuloma Inguinale

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Anatomical Context for Granuloma Inguinale

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Granuloma Inguinale:

32
Skin, Cervix, Bone, Testes, Lymph node, Spinal cord, Uterus

FMA organs/tissues related to Granuloma Inguinale:

14
Skin or

Animal Models for Granuloma Inguinale or affiliated genes

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Publications for Granuloma Inguinale

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50PubMed
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Articles related to Granuloma Inguinale:

(show top 50)    (show all 262)
idTitleAuthorsYear
1
Malignant transformation of donovanosis (granuloma inguinale) in a HIV-positive patient. (19061590)
2008
2
Surgical treatment of granuloma inguinale. (9747380)
1998
3
Disseminated donovanosis (granuloma inguinale) causing spinal cord compression: case report and review of donovanosis involving bone. (9502458)
1998
4
Granuloma inguinale: self-assessment. (8642110)
1996
5
Laboratory techniques used in the diagnosis of chancroid, granuloma inguinale, and lymphogranuloma venereum. (8143374)
1994
6
Donovanosis (granuloma inguinale) in pregnancy. (1782239)
1991
7
Perianal abscess and sinuses caused by granuloma inguinale. Case report. (2618517)
1989
8
Granuloma inguinale of cervical lymph nodes simulating tuberculous lymphadenitis: two case reports and review of published reports. (3060425)
1988
9
The treatment of gonorrhea, syphilis, chancroid, lymphogranuloma venereum, and granuloma inguinale. (3042224)
1988
10
Granuloma inguinale in a white teenager--a diagnosis easily forgotten, poorly pursued. (4036107)
1985
11
Granuloma inguinale. (6384290)
1984
12
Granuloma inguinale (donovanosis) in South Africa. (6845058)
1983
13
Granuloma inguinale. (7226888)
1981
14
Extragenital granuloma inguinale in North Queensland. (7464603)
1980
15
Granuloma venereum (granuloma inguinale) in Zambia. (614129)
1977
16
Granuloma inguinale simulating advanced pelvic cancer. (1022224)
1976
17
Granuloma inguinale in Vietnam: successful therapy with ampicillin and lincomycin. (1165215)
1975
18
Granuloma inguinale. (4635618)
1972
19
Granuloma inguinale: an ultrastructural study of Calymmatobacterium granulomatis. (5347410)
1969
20
Granuloma inguinale. Report of a case in California with notes on pathogenesis. (5942015)
1966
21
STUDIES ON GRANULOMA INGUINALE. VII. SOME EPIDEMIOLOGICAL CONSIDERATIONS OF THE DISEASE. (14169943)
1964
22
Treatment of granuloma inguinale with triacetyloleandomycin. Report of a case. (13752597)
1961
23
Studies on granuloma inguinale. IV. Growth requirements of Donovania granulomatis and its relationship to the natural habitat of the organism. (13850593)
1959
24
Disseminated granuloma inguinale and its relationship to granuloma of the cervix and pregnancy. (13458259)
1957
25
Intravenous terramycin in the treatment of early syphilis and granuloma inguinale. (13114580)
1954
26
Studies on granuloma inguinale. III. The antigenic heterogeneity of Donovania granulomatis. (13158754)
1954
27
Squamous cell carcinoma of the vulva secondary to granuloma inguinale. (13039574)
1953
28
Aureomycin in the treatment of granuloma inguinale. (13084925)
1953
29
Case for diagnosis; granuloma inguinale, involving the perineum. (12996075)
1952
30
Antibiotics in treatment of lymphogranuloma venereum and granuloma inguinale. (13139188)
1952
31
Granuloma inguinale in the African Negro. (14805861)
1951
32
Present day treatment of chancroid, lymphogranuloma venereum, and granuloma inguinale. (14798879)
1950
33
Granuloma inguinale treated with streptomycin. (18890556)
1948
34
The antigenic relationships of Donovania granulomatis (Anderson) and the significance of this organism in granuloma inguinale. (18902198)
1948
35
Isolation and cultivation of the Donovan bodies of granuloma inguinale. (18101932)
1948
36
Streptomycin in the treatment of granuloma inguinale. (18876343)
1948
37
Four cases of granuloma inguinale of cervix diagnosed clinically as carcinoma. (18893782)
1948
38
Granuloma inguinale; treatment with streptomycin. (18870023)
1948
39
Laboratory diagnosis of granuloma inguinale and studies on the cultivation of the Donovan body. (18867293)
1948
40
Granuloma inguinale. (18905286)
1948
41
Granuloma inguinale; streptomycin therapy and research. (20258816)
1947
42
Studies on the causal agent of granuloma inguinale. (20268940)
1947
43
Socioeconomic aspects of granuloma inguinale. (20258815)
1947
44
Granuloma inguinale involving buttock and lymph node; cultivation of the Donovan body in embryonic yolk. (20287965)
1947
45
Oral lesions of granuloma inguinale; report of three cases. (20983328)
1946
46
Granuloma inguinale]. (20340218)
1946
47
Action of chemotherapeutic agents on the organism of granuloma inguinale. (20984588)
1946
48
Treatment of granuloma inguinale with anthiomaline; report of case with extragenital lesion. (21005454)
1945
49
IMMUNOLOGIC RELATIONSHIP OF DONOVANIA GRANULOMATIS TO GRANULOMA INGUINALE. (19871442)
1945
50
Lymphogranuloma Inguinale and Granuloma Inguinale. (20319770)
1935

Genetic Variations for Granuloma Inguinale

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Expression for genes affiliated with Granuloma Inguinale

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Granuloma Inguinale

Search GEO for disease gene expression data for Granuloma Inguinale.

Pathways for genes affiliated with Granuloma Inguinale

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Compounds for genes affiliated with Granuloma Inguinale

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB
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Compounds related to Granuloma Inguinale according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1testosterone44 59 11 2412.1NRIP1, WT1
2retinoic acid44 2410.1NRIP1, WT1
3steroid449.0NRIP1, WT1
4estrogen448.8NRIP1, WT1

GO Terms for genes affiliated with Granuloma Inguinale

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16Gene Ontology
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Biological processes related to Granuloma Inguinale according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of transcription from RNA polymerase II promoterGO:0001229.1NRIP1, WT1
2positive regulation of transcription, DNA-dependentGO:0458938.8NRIP1, WT1

Products for genes affiliated with Granuloma Inguinale

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Granuloma Inguinale

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet