MCID: GRN005
MIFTS: 37

Granuloma Inguinale malady

Infectious diseases category

Summaries for Granuloma Inguinale

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A primary bacterial infectious disease that results in infection located in skin or located in mucosa of genital tract, has material basis in klebsiella granulomatis, transmitted by sexual contact or transmitted by contact with the open sores. the infection has symptom painless genital ulcers.

MalaCards: Granuloma Inguinale, also known as donovanosis, is related to lymphogranuloma venereum and chancroid, and has symptoms including painless genital ulcers An important gene associated with Granuloma Inguinale is NRIP1 (nuclear receptor interacting protein 1). The compounds testosterone and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include skin or, skin and cervix.

Wikipedia:63 Granuloma inguinale is a bacterial disease caused by Klebsiella granulomatis characterized by ulcerative... more...

Aliases & Classifications for Granuloma Inguinale

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 39NCIt, 27ICD9CM, 34MeSH, 56SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

granuloma inguinale 8 42 10 60
donovanosis 8 42
pudendal ulcer 8


External Ids:

Disease Ontology8 DOID:9113
NCIt39 C3065
ICD9CM27 099.2
SNOMED-CT56 186947000, 28867007
MeSH34 D006100
ICD1025 A58

Related Diseases for Granuloma Inguinale

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17GeneCards, 18GeneDecks
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Diseases related to Granuloma Inguinale via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 21)
idRelated DiseaseScoreTop Affiliating Genes
1lymphogranuloma venereum10.8
2chancroid10.7
3gonorrhea10.4
4cervicitis10.4
5syphilis10.4
6squamous cell carcinoma10.3
7vaginitis10.3
8endocervicitis10.1
9myoblastoma10.1
10orbital granuloma10.1
11mucinous adenocarcinoma10.1
12adenocarcinoma10.1
13lymphadenitis10.1
14osteomyelitis10.1
15otitis media10.1
16vulva squamous cell carcinoma10.1
17elephantiasis10.1
18infertility10.0NRIP1
19down syndrome10.0NRIP1
20hairy cell leukemia10.0
21leukemia10.0

Graphical network of the top 20 diseases related to Granuloma Inguinale:



Diseases related to granuloma inguinale

Clinical Features for Granuloma Inguinale

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8Disease Ontology
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Symptoms:

8
  • painless genital ulcers

Drugs & Therapeutics for Granuloma Inguinale

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Granuloma Inguinale

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Anatomical Context for Granuloma Inguinale

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Granuloma Inguinale:

32
Skin, Cervix, Bone, Testes, Lymph node, Spinal cord, Uterus

FMA organs/tissues related to Granuloma Inguinale:

14
Skin or

Animal Models for Granuloma Inguinale or affiliated genes

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Publications for Granuloma Inguinale

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50PubMed
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Articles related to Granuloma Inguinale:

(show top 50)    (show all 262)
idTitleAuthorsYear
1
Cutaneous metastases of rectal mucinous adenocarcinoma mimicking granuloma inguinale. (22975572)
2012
2
Donovanosis (granuloma inguinale). (17151047)
2006
3
Disseminated donovanosis (granuloma inguinale) with osteomyelitis of both wrists. (12501553)
2002
4
Transepithelial elimination of cutaneous vulval granuloma inguinale. (11100808)
2000
5
Growth and cultural characteristics of Calymmatobacterium granulomatis--the aetiological agent of granuloma inguinale (Donovanosis). (9236742)
1997
6
Mucocutaneous manifestations of chancroid, lymphogranuloma venereum and granuloma inguinale. (8304262)
1994
7
Failure of single dose ceftriaxone in donovanosis (granuloma inguinale) (1582667)
1992
8
Failure of single dose ceftriaxone in donovanosis (granuloma inguinale) (2071134)
1991
9
A rapid stain for the diagnosis of granuloma inguinale. (1712751)
1991
10
Granuloma inguinale of the cervix: a carcinoma look-alike. (2245986)
1990
11
A rapid stain for the diagnosis of granuloma inguinale. (1695193)
1990
12
HIV and granuloma inguinale in Durban. (2256986)
1990
13
Extragenital granuloma inguinale mimicking a soft-tissue neoplasm: a case report and review of the literature. (1692564)
1990
14
The treatment of donovanosis (granuloma inguinale). (3358238)
1988
15
HIV, genital ulceration, and granuloma inguinale. (3129088)
1988
16
Granuloma inguinale. (6395376)
1984
17
A clinical variant of chancroid resembling granuloma inguinale. (6639108)
1983
18
Granuloma inguinale (donovanosis). (7394692)
1980
19
Status of granuloma inguinale in Papua New Guinea. (299329)
1979
20
Granuloma inguinale in Botswana. (505563)
1979
21
Tetracycline-resistant granuloma inguinale. (879828)
1977
22
Epidemiological and clinical features in 165 cases of granuloma inguinale. (5533203)
1970
23
Granuloma inguinale with bone involvement. (5832201)
1965
24
Granuloma inguinale. (13851907)
1960
25
Intramuscular oxytetracycline (terramycin) in the treatment of chancroid, lymphogranuloma venereum, and granuloma inguinale. (13363371)
1956
26
A case of granuloma inguinale successfully treated with chloromycetin. (13034356)
1953
27
GRANULOMA venereum; granuloma inguinale; ulcerating granuloma of the genitalia. (12995072)
1952
28
Granuloma inguinale in the Himachal Pradesh, India. (14910161)
1952
29
The epithelial changes in granuloma inguinale. (12996726)
1952
30
A simple stain for Donovan bodies for the diagnosis of granuloma inguinale. (14838253)
1951
31
The diagnosis and treatment of certain infections of the vulva and vagina: Granuloma inguinale; lymphopathia venereum; monilia vulvo-vaginitis; condylomata acuminata. (14787654)
1950
32
Aureomycin in the treatment of granuloma inguinale and lymphogranuloma venereum. (15428705)
1950
33
Granuloma inguinale. (18141431)
1949
34
Chloromycetin in the therapy of granuloma inguinale. (18126829)
1949
35
Aureomycin in the treatment of granuloma inguinale. (18146532)
1949
36
Ambulatory treatment of granuloma inguinale with streptomycin. (18144230)
1949
37
Streptomycin therapy in granuloma inguinale. (18901720)
1948
38
Chancroid, lymphogranuloma venereum and granuloma inguinale; diagnosis and treatment. (18890476)
1948
39
Extragenital granuloma inguinale; report of a case. (18876787)
1948
40
Granuloma inguinale. (18101705)
1948
41
Pseudoepitheliomatous hyperplasia due to granuloma inguinale. (20272213)
1947
42
Streptomycin in the therapy of granuloma inguinale. (20239432)
1947
43
Complement fixation studies with pus antigen in granuloma inguinale. (20250452)
1947
44
Granuloma inguinale with perianal involvement; report of a case. (20267423)
1947
45
Cultural and serological studies on granuloma inguinale. (20987068)
1946
46
Pathologic findings in a fatal case of disseminated granuloma inguinale with miliary bone and joint involvement. (20280879)
1946
47
Observations on the cause and transmission of granuloma inguinale. (21001255)
1946
48
Granuloma inguinale. (21065276)
1946
49
Granuloma Inguinale and Lymphogranuloma Inguinale. (20322550)
1942
50
Laboratory Aspects of Chancroid, Granuloma Inguinale and Lymphogranuloma Venereum. (18015247)
1940

Genetic Variations for Granuloma Inguinale

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Expression for genes affiliated with Granuloma Inguinale

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Granuloma Inguinale

Search GEO for disease gene expression data for Granuloma Inguinale.

Pathways for genes affiliated with Granuloma Inguinale

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Compounds for genes affiliated with Granuloma Inguinale

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 24HMDB
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Compounds related to Granuloma Inguinale according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1testosterone44 59 11 2412.1NRIP1, WT1
2retinoic acid44 2410.1NRIP1, WT1
3steroid449.0NRIP1, WT1
4estrogen448.8NRIP1, WT1

GO Terms for genes affiliated with Granuloma Inguinale

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16Gene Ontology
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Biological processes related to Granuloma Inguinale according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of transcription from RNA polymerase II promoterGO:0001229.1NRIP1, WT1
2positive regulation of transcription, DNA-dependentGO:0458938.8NRIP1, WT1

Products for genes affiliated with Granuloma Inguinale

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Granuloma Inguinale

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet