MCID: GRN003
MIFTS: 38

Granulomatous Dermatitis malady

Skin diseases category
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Summaries for Granulomatous Dermatitis

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33MalaCards
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MalaCards: Granulomatous Dermatitis is related to arthritis and systemic lupus erythematosus. An important gene associated with Granulomatous Dermatitis is NOD2 (nucleotide-binding oligomerization domain containing 2), and among its related pathways are Leishmaniasis and Tuberculosis. The compounds il 10 and infliximab have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and t cells, and related mouse phenotypes are hematopoietic system and growth/size/body.

Aliases & Classifications for Granulomatous Dermatitis

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8Disease Ontology, 62UMLS, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

granulomatous dermatitis 8 62


External Ids:

Disease Ontology8 DOID:4397
NCIt40 C3505

Related Diseases for Granulomatous Dermatitis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Granulomatous Dermatitis:



Diseases related to granulomatous dermatitis

Symptoms for Granulomatous Dermatitis

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Drugs & Therapeutics for Granulomatous Dermatitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Granulomatous Dermatitis

Search NIH Clinical Center for Granulomatous Dermatitis

Genetic Tests for Granulomatous Dermatitis

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Anatomical Context for Granulomatous Dermatitis

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33MalaCards
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MalaCards organs/tissues related to Granulomatous Dermatitis:

33
Skin, Thyroid, T cells

Animal Models for Granulomatous Dermatitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Granulomatous Dermatitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.5NOD2, ACE, TNF
2MP:00053788.5NOD2, ACE, TNF
3MP:00053878.4NOD2, ACE, TNF
4MP:00053848.2TNF, ACE, NOD2

Publications for Granulomatous Dermatitis

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52PubMed
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Articles related to Granulomatous Dermatitis:

(show top 50)    (show all 129)
idTitleAuthorsYear
1
Ustekinumab therapy for severe interstitial granulomatous dermatitis with arthritis. (23677104)
2013
2
Perforating granulomatous dermatitis reaction to exogenous tattoo pigment: a case report and review of the literature. (21986232)
2013
3
Generalized Granulomatous Dermatitis Accompanied by Myelodysplastic Syndrome. (23817627)
2013
4
A palpable erythematous cord over the trunk in a patient with systemic lupus erythematosus. Interstitial granulomatous dermatitis (IGD). (23677093)
2013
5
Combination therapy with intralesional triamcinolone and oral dapsone for management of palisaded neutrophilic and granulomatous dermatitis. (23473287)
2013
6
Interstitial granulomatous dermatitis and arthritis revealing oesophageal carcinoma. (23777491)
2013
7
A cutaneous interstitial granulomatous dermatitis-like eruption arising in myelodysplasia with leukemic progression. (23221468)
2013
8
Interstitial granulomatous dermatitis with arthritis presenting with the rope sign. (23531209)
2013
9
Palisaded neutrophilic and granulomatous dermatitis in a rheumatoid arthritis patient after treatment with adalimumab. (24201093)
2013
10
Palisaded neutrophilic and granulomatous dermatitis in an adolescent girl with perinuclear antineutrophil cytoplasmic antibody-positive pauci-immune glomerulonephritis and arthritis. (22980283)
2012
11
Interstitial granulomatous dermatitis: a distinct entity with characteristic histological and clinical pattern. (22059717)
2012
12
Images in clinical medicine. Palisaded neutrophilic and granulomatous dermatitis. (22646653)
2012
13
Interstitial granulomatous dermatitis? An unusual presentation in the mucosa and periungual skin. (21352283)
2011
14
Interstitial granulomatous dermatitis in a patient with lupus erythematosus. (21986235)
2011
15
Isolated unilateral palisaded neutrophilic and granulomatous dermatitis. (21860170)
2011
16
Palisaded neutrophilic and granulomatous dermatitis in association with sarcoidosis. (20528967)
2011
17
Interstitial granulomatous dermatitis: another clinical variant. (22087092)
2011
18
Palisaded neutrophilic and granulomatous dermatitis: a presenting sign of sarcoidosis? (21839329)
2011
19
Palisaded neutrophilic granulomatous dermatitis without a definable underlying disorder treated with dapsone. (21839310)
2011
20
Interstitial granulomatous dermatitis in rheumatoid arthritis responsive to etanercept. (19802716)
2010
21
Necrotizing palisaded granulomatous dermatitis as a manifestation of familial hemophagocytic lymphohistiocytosis. (19903216)
2010
22
Interstitial granulomatous dermatitis in a patient with rheumatoid arthritis on etanercept. (19271571)
2009
23
Interstitial granulomatous dermatitis in a child with chronic uveitis. (18489032)
2008
24
Interstitial granulomatous dermatitis in a patient with rheumatoid arthritis on etanercept. (18491481)
2008
25
Interstitial granulomatous dermatitis: a misdiagnosed cutaneous form of systemic lupus erythematosus? (18681887)
2008
26
Early lesion of palisaded neutrophilic granulomatous dermatitis in ulcerative colitis. (17483043)
2007
27
Interstitial granulomatous dermatitis associated with autoimmune hepatitis. (17447986)
2007
28
Infliximab therapy for interstitial granulomatous dermatitis. (17243965)
2007
29
Perforating neutrophilic and granulomatous dermatitis of the newborn--a clue to immunodeficiency. (17542866)
2007
30
Lichenoid and granulomatous dermatitis associated with atypical mycobacterium infections. (16872476)
2006
31
Interstitial granulomatous dermatitis associated with the use of tumor necrosis factor alpha inhibitors. (16490847)
2006
32
Granulomatous dermatitis with enlarged histiocytes: a characteristic pattern of granulocyte colony-stimulating factor. Report of two cases and review of the literature. (16484826)
2006
33
Palisaded neutrophilic granulomatous dermatitis presenting as an unusual skin manifestation in a patient with BehAset's disease. (16195168)
2005
34
Palisading neutrophilic granulomatous dermatitis in a Japanese patient with Wegener's granulomatosis. (16043926)
2005
35
Palisaded neutrophilic and granulomatous dermatitis: an unusual cutaneous manifestation of immune-mediated disorders. (15609265)
2004
36
Interstitial granulomatous dermatitis with plaques and arthritis. (14579165)
2003
37
Interstitial granulomatous dermatitis with histiocytic pseudorosettes: a new histopathologic pattern in cutaneous borreliosis. Detection of Borrelia burgdorferi DNA sequences by a highly sensitive PCR-ELISA. (12637917)
2003
38
Interstitial granulomatous dermatitis with plaques and arthritis. (12804998)
2003
39
Photo quiz. Palisaded neutrophilic and granulomatous dermatitis with underlying Wegener's granulomatosis. (12184668)
2002
40
Interstitial granulomatous dermatitis with plaques. (12063487)
2002
41
Granulomatous dermatitis in a spadefoot toad (Scaphiopus holbrooki). (12189601)
2002
42
Lichenoid and granulomatous dermatitis. (10692062)
2000
43
The histopathologic spectrum of palisaded neutrophilic and granulomatous dermatitis in patients with collagen vascular disease. (7944509)
1994
44
Granulomatous dermatitis and Zyderm. (8016250)
1994
45
Granulomatous dermatitis to iron oxide after permanent pigmentation of the eyebrows. (8454784)
1993
46
Granulomatous dermatitis in peach-faced lovebirds. (3426471)
1987
47
Recurrent granulomatous dermatitis with eosinophilia. Wells' syndrome. (6724778)
1984
48
Periocular dermatitis: a micropapular sarcoid-like granulomatous dermatitis in a woman. (7250477)
1981
49
Wells' syndrome. Recurrent granulomatous dermatitis with eosinophilia. (443839)
1979
50
Lymphomatoid granulomatosis preceded by chronic granulomatous dermatitis. (718200)
1978

Variations for Granulomatous Dermatitis

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Expression for genes affiliated with Granulomatous Dermatitis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Granulomatous Dermatitis

Search GEO for disease gene expression data for Granulomatous Dermatitis.

Pathways for genes affiliated with Granulomatous Dermatitis

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50PathCards, 30KEGG, 54R&D Systems, 60Thomson Reuters, 38NCBI BioSystems Database, 55Reactome
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Pathways related to Granulomatous Dermatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3TNF, NOD2
29.3NOD2, TNF
3
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.3NOD2, TNF
49.3NOD2, TNF
5
Show member pathways
9.3NOD2, TNF
69.3NOD2, TNF
7
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.1ACE, TNF
8
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy38
9.1ACE, TNF

Compounds for genes affiliated with Granulomatous Dermatitis

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Sources:
45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB
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Compounds related to Granulomatous Dermatitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1il 10459.5NOD2, TNF
2infliximab45 51 1111.5NOD2, TNF
3peptidoglycan45 2910.5TNF, NOD2
4prednisolone45 29 1111.3TNF, NOD2
5tacrolimus45 51 1111.3NOD2, TNF
6endotoxin459.2NOD2, TNF
7atorvastatin45 51 29 24 1113.2TNF, ACE
8prostacyclin458.8ACE, TNF
9nitric oxide45 24 1110.6NOD2, ACE, TNF

GO Terms for genes affiliated with Granulomatous Dermatitis

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16Gene Ontology
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Cellular components related to Granulomatous Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099869.3NOD2, TNF
2external side of plasma membraneGO:0098978.8ACE, TNF

Biological processes related to Granulomatous Dermatitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of humoral immune response mediated by circulating immunoglobulinGO:0029259.6NOD2, TNF
2negative regulation of growth of symbiont in hostGO:0441309.5NOD2, TNF
3defense response to Gram-positive bacteriumGO:0508309.5TNF, NOD2
4positive regulation of interleukin-6 productionGO:0327559.5NOD2, TNF
5JNK cascadeGO:0072549.4NOD2, TNF
6positive regulation of JNK cascadeGO:0463309.4TNF, NOD2
7activation of MAPK activityGO:0001879.3NOD2, TNF
8positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.3NOD2, TNF
9positive regulation of ERK1 and ERK2 cascadeGO:0703749.2NOD2, TNF
10positive regulation of NF-kappaB transcription factor activityGO:0510929.0NOD2, TNF

Products for genes affiliated with Granulomatous Dermatitis

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Sources for Granulomatous Dermatitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet