MCID: GRN003
MIFTS: 38

Granulomatous Dermatitis

Categories: Skin diseases

Aliases & Classifications for Granulomatous Dermatitis

MalaCards integrated aliases for Granulomatous Dermatitis:

Name: Granulomatous Dermatitis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4397
NCIt 46 C3505
UMLS 69 C0743086

Summaries for Granulomatous Dermatitis

MalaCards based summary : Granulomatous Dermatitis is related to arthritis and blau syndrome. An important gene associated with Granulomatous Dermatitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Development Angiotensin activation of ERK. Affiliated tissues include neutrophil, skin and b cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Related Diseases for Granulomatous Dermatitis

Diseases related to Granulomatous Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 arthritis 30.4 NOD2 TNF TNFRSF1B
2 blau syndrome 30.1 NOD2 TNF
3 leprosy 3 29.8 NOD2 TNF
4 lymphadenitis 29.7 NOD2 TNF
5 silicosis 29.5 ACE TNF
6 spondyloarthropathy 1 29.3 NOD2 TNF TNFRSF1B
7 spondylitis 29.3 NOD2 TNF TNFRSF1B
8 uveitis 29.0 NOD2 TNF
9 interstitial granulomatous dermatitis with arthritis 12.4
10 dermatitis 10.8
11 ileocolitis 10.3 NOD2 TNF
12 crohn's colitis 10.3 NOD2 TNF
13 inflammatory bowel disease 3 10.3 NOD2 TNF
14 streptococcal meningitis 10.3 NOD2 TNF
15 hidradenitis suppurativa 10.3 NOD2 TNF
16 hidradenitis 10.3 NOD2 TNF
17 pyoderma gangrenosum 10.2 NOD2 TNF
18 pyoderma 10.2 NOD2 TNF
19 ileitis 10.2 NOD2 TNF
20 acute graft versus host disease 10.2 NOD2 TNF
21 rheumatoid lung disease 10.2 TNF TNFRSF1B
22 chronic gonococcal salpingitis 10.2 TNF TNFRSF1B
23 scleral disease 10.2 TNF TNFRSF1B
24 pustulosis of palm and sole 10.2 TNF TNFRSF1B
25 peroneal neuropathy 10.2 TNF TNFRSF1B
26 periodic fever, familial, autosomal dominant 10.2 TNF TNFRSF1B
27 sweat gland disease 10.2 TNF TNFRSF1B
28 acute salpingitis 10.2 TNF TNFRSF1B
29 post-transplant lymphoproliferative disease 10.2 TNF TNFRSF1B
30 panuveitis 10.2 TNF TNFRSF1B
31 rheumatoid arthritis 10.2
32 familial mediterranean fever 10.2 NOD2 TNF
33 chronic salpingitis 10.2 TNF TNFRSF1B
34 palindromic rheumatism 10.2 TNF TNFRSF1B
35 exanthem 10.1 TNF TNFRSF1B
36 cogan syndrome 10.1 TNF TNFRSF1B
37 subacute cutaneous lupus erythematosus 10.1 ACE TNF
38 lupus erythematosus 10.1
39 posterior urethral valves 10.1 ACE TNF
40 guillain-barre syndrome 10.1 TNF TNFRSF1B
41 ischemic heart disease 10.1 ACE TNF
42 systemic lupus erythematosus 10.1
43 extrinsic cardiomyopathy 10.1 ACE TNF
44 bone inflammation disease 10.1 TNF TNFRSF1B
45 rheumatic heart disease 10.1 ACE TNF
46 pyelonephritis 10.1 ACE TNF
47 limb ischemia 10.1 ACE TNF
48 granulomatous hepatitis 10.0 ACE TNFRSF1B
49 juvenile rheumatoid arthritis 10.0 TNF TNFRSF1B
50 adult respiratory distress syndrome 10.0 ACE TNF

Graphical network of the top 20 diseases related to Granulomatous Dermatitis:



Diseases related to Granulomatous Dermatitis

Symptoms & Phenotypes for Granulomatous Dermatitis

GenomeRNAi Phenotypes related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.55 TNFRSF1B ACE NOD2 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.55 TNFRSF1B ACE BRAF NOD2 TNF

MGI Mouse Phenotypes related to Granulomatous Dermatitis:

43 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.93 TNF FOXC1 TNFRSF1B ACE NOD2 BRAF
2 cardiovascular system MP:0005385 9.92 TNFRSF1B BRAF TNF FOXC1 ACE
3 homeostasis/metabolism MP:0005376 9.91 TNFRSF1B BRAF TNF FOXC1 ACE NOD2
4 digestive/alimentary MP:0005381 9.89 TNF FOXC1 TNFRSF1B NOD2 BRAF
5 endocrine/exocrine gland MP:0005379 9.88 TNFRSF1B BRAF TNF FOXC1 ACE
6 mortality/aging MP:0010768 9.85 TNFRSF1B BRAF TNF FOXC1 ACE NOD2
7 adipose tissue MP:0005375 9.84 TNFRSF1B BRAF TNF ACE
8 craniofacial MP:0005382 9.81 TNFRSF1B BRAF TNF FOXC1
9 liver/biliary system MP:0005370 9.8 FOXC1 TNFRSF1B ACE BRAF TNF
10 muscle MP:0005369 9.62 TNFRSF1B BRAF TNF FOXC1
11 neoplasm MP:0002006 9.56 TNFRSF1B BRAF TNF ACE
12 renal/urinary system MP:0005367 9.46 TNFRSF1B BRAF FOXC1 ACE
13 respiratory system MP:0005388 9.26 TNFRSF1B BRAF TNF FOXC1
14 skeleton MP:0005390 9.02 TNFRSF1B TNF FOXC1 NOD2 BRAF

Drugs & Therapeutics for Granulomatous Dermatitis

Search Clinical Trials , NIH Clinical Center for Granulomatous Dermatitis

Genetic Tests for Granulomatous Dermatitis

Anatomical Context for Granulomatous Dermatitis

MalaCards organs/tissues related to Granulomatous Dermatitis:

38
Neutrophil, Skin, B Cells, Prostate, Thyroid, T Cells

Publications for Granulomatous Dermatitis

Articles related to Granulomatous Dermatitis:

(show top 50) (show all 188)
# Title Authors Year
1
Palisading neutrophilic and granulomatous dermatitis as a presentation of Hodgkin lymphoma: A case and review. ( 29226345 )
2018
2
Palisaded Neutrophilic and Granulomatous Dermatitis/Interstitial Granulomatous Dermatitis Overlap: A Striking Clinical and Histologic Presentation With "Burning Rope Sign" and Subsequent Mirror-Image Contralateral Recurrence. ( 28475518 )
2017
3
Palisaded Granulomatous Dermatitis Associated with Ulcerative Colitis: A Comprehensive Literature Review. ( 28168136 )
2017
4
Palisaded granulomatous dermatitis secondary to recombinant insulin. ( 28252209 )
2017
5
Reactive granulomatous dermatitis presenting as subcutaneous nodules and cords in a patient with advanced myelodysplastic syndrome. ( 28220192 )
2017
6
Interstitial granulomatous dermatitis associated with lupus: A case report. ( 28359766 )
2017
7
Interstitial Granulomatous Dermatitis with Granuloma Annulare-Like Pattern Following Liposuction. ( 28946733 )
2017
8
Interstitial granulomatous dermatitis during talimogen laherparepvec treatment. ( 28570389 )
2017
9
Generalized palisaded neutrophilic and granulomatous dermatitis-a cutaneous manifestation of chronic myelomonocytic leukemia? A clinical, histopathological, and molecular study of 3 cases. ( 28442268 )
2017
10
Palisaded neutrophilic and granulomatous dermatitis as a novel cause of hypercalcemia: A case report. ( 28538395 )
2017
11
Scabies Associated with Granulomatous Dermatitis. ( 28868002 )
2017
12
Interstitial granulomatous dermatitis with arthritis. ( 29186271 )
2017
13
Chronic Granulomatous Dermatitis Induced by Talimogene Laherparepvec Therapy of Melanoma Metastases. ( 28940544 )
2017
14
Interstitial Granulomatous Dermatitis (IGD). ( 28785357 )
2017
15
Interstitial granulomatous dermatitis associated with primary biliary cirrhosis. ( 28225148 )
2017
16
Postherpetic Granulomatous Dermatitis in a Man Treated With Nivolumab. ( 28532783 )
2017
17
Palisaded Neutrophilic Granulomatous Dermatitis in a Patient with Systemic Sclerosis-Rheumatoid Arthritis Overlap Syndrome. ( 29200777 )
2017
18
Interstitial granulomatous dermatitis associated with rheumatoid arthritis. ( 28150331 )
2017
19
Palisaded neutrophilic granulomatous dermatitis: Spectrum of histologic findings in a single patient. ( 28932786 )
2017
20
Interstitial Granulomatous Dermatitis in a Patient with Prostate Cancer. ( 28566913 )
2017
21
Use of Molecular Biology Techniques in Sarcoidal Granulomatous Dermatitis: A Clinicopathological and Molecular Approach with Diagnostic Implications. ( 28681062 )
2017
22
First reported association of chronic lymphocytic leukaemia and interstitial granulomatous dermatitis. ( 27194675 )
2016
23
Infectious Granulomatous Dermatitis at a Tertiary Care Centre in North Maharashtra: A Histopathological Study. ( 28050374 )
2016
24
Generalized granulomatous dermatitis following Mycobacterium w (Mw) immunotherapy in lepromatous leprosy. ( 27891733 )
2016
25
Subcutaneous Dirofilariasis: A Masquerade of a Palisaded Granulomatous Dermatitis. ( 28000235 )
2016
26
Interstitial granulomatous dermatitis demonstrating small, discrete skin-colored papules. ( 27373135 )
2016
27
Interstitial granulomatous dermatitis occurring in a patient with SAPHO syndrome one month after starting leflunomide, and subsequently disappearing with ustekinumab. ( 27456988 )
2016
28
Papulonodular mucinosis with interstitial granulomatous dermatitis-like histological changes in a male patient with systemic lupus erythematosus. ( 27421677 )
2016
29
Complete remission of disseminated granulomatous dermatitis related to chronic eosinophilic leukemia following allogeneic stem cell transplantation. ( 27267816 )
2016
30
Palisaded neutrophilic and granulomatous dermatitis - cutaneous manifestation of Lyme disease or connected with CTD? Case report. ( 27294654 )
2016
31
Interstitial Granulomatous Dermatitis Associated with Rheumatoid Arthritis. ( 27274645 )
2016
32
The rope sign: a case of interstitial granulomatous dermatitis with arthritis. ( 26924028 )
2016
33
Palisaded Neutrophilic Granulomatous Dermatitis in a Child with Juvenile Idiopathic Arthritis on Etanercept. ( 26860064 )
2016
34
BRAF Inhibitor-Induced Antitumoral Granulomatous Dermatitis Eruption in Advanced Melanoma. ( 26381028 )
2015
35
Interstitial Granulomatous Dermatitis: A Clinicopathological Study. ( 25830722 )
2015
36
Interstitial granulomatous dermatitis associated with systemic lupus erythematosus: case report and review of the literature. ( 26385222 )
2015
37
Interstitial granulomatous dermatitis: a characteristic histological pattern with variable clinical manifestations. ( 26755914 )
2015
38
Interstitial Granulomatous Dermatitis as the Initial Manifestation of Myeloma. ( 26039702 )
2015
39
Granulocyte colony-stimulating factor-induced granulomatous dermatitis with enlarged histiocytes clinically manifesting as painful edematous nodules with high fever similar to Sweet's syndrome. ( 25572429 )
2015
40
Herpes zoster granulomatous dermatitis: histopathologic findings in a case series. ( 25970643 )
2015
41
Reactive Granulomatous Dermatitis: A Review of Palisaded Neutrophilic and Granulomatous Dermatitis, Interstitial Granulomatous Dermatitis, Interstitial Granulomatous Drug Reaction, and a Proposed Reclassification. ( 26143420 )
2015
42
Chronic Interstitial Granulomatous Dermatitis in Coccidioidomycosis. ( 26574343 )
2015
43
Granulomatous Dermatitis as a Cutaneous Manifestation of Hematologic Disorders: The First Case Associated With Polycythemia Vera and a New Case Associated With Myelodysplasia. ( 26703820 )
2015
44
Anisakis spp. induced granulomatous dermatitis in a harbour porpoise Phocoena phocoena and a bottlenose dolphin Tursiops truncatus. ( 25590777 )
2015
45
Interstitial granulomatous dermatitis with prominent neutrophil infiltration. ( 26566699 )
2015
46
Interstitial granulomatous dermatitis: rare cutaneous manifestation of rheumatoid arthritis. ( 26131871 )
2015
47
Granulomatous dermatitis in a 29-year-old man from Bangladesh. ( 26882390 )
2015
48
Interstitial granulomatous dermatitis due to borreliosis. ( 25851752 )
2015
49
Interstitial Granulomatous Dermatitis Associated with Myelodysplastic Syndrome - Complete Clearance Under Therapy with 5-azacytidine. ( 24573709 )
2014
50
Exacerbation of interstitial granulomatous dermatitis with arthritis by anakinra in a patient with diffuse large B-cell lymphoma. ( 24480300 )
2014

Variations for Granulomatous Dermatitis

Expression for Granulomatous Dermatitis

Search GEO for disease gene expression data for Granulomatous Dermatitis.

Pathways for Granulomatous Dermatitis

Pathways related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.91 BRAF NOD2 TNF TNFRSF1B
2
Show member pathways
12.48 BRAF TNF TNFRSF1B
3
Show member pathways
12.39 BRAF TNF TNFRSF1B
4
Show member pathways
12.21 BRAF TNF TNFRSF1B
5
Show member pathways
11.96 BRAF TNF TNFRSF1B
6
Show member pathways
11.47 TNF TNFRSF1B
7
Show member pathways
11.39 TNF TNFRSF1B
8 11.35 TNF TNFRSF1B
9
Show member pathways
11.26 BRAF TNF
10 11.19 TNF TNFRSF1B
11
Show member pathways
11.1 TNF TNFRSF1B
12 11.06 TNF TNFRSF1B
13 10.83 NOD2 TNF TNFRSF1B
14
Show member pathways
10.81 TNF TNFRSF1B
15 10.66 TNF TNFRSF1B
16 10.32 NOD2 TNF

GO Terms for Granulomatous Dermatitis

Biological processes related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.69 BRAF FOXC1 TNF
2 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.58 BRAF TNF
3 cellular response to organic cyclic compound GO:0071407 9.57 NOD2 TNF
4 apoptotic signaling pathway GO:0097190 9.56 TNF TNFRSF1B
5 regulation of inflammatory response GO:0050727 9.55 NOD2 TNF
6 positive regulation of JNK cascade GO:0046330 9.54 NOD2 TNF
7 positive regulation of MAP kinase activity GO:0043406 9.52 NOD2 TNF
8 JNK cascade GO:0007254 9.49 NOD2 TNF
9 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.48 TNF TNFRSF1B
10 positive regulation of interleukin-6 production GO:0032755 9.46 NOD2 TNF
11 extrinsic apoptotic signaling pathway GO:0097191 9.43 TNF TNFRSF1B
12 regulation of cell proliferation GO:0042127 9.43 BRAF TNF TNFRSF1B
13 negative regulation of mitotic cell cycle GO:0045930 9.4 FOXC1 TNF
14 blood vessel remodeling GO:0001974 9.37 ACE FOXC1
15 positive regulation of interleukin-8 production GO:0032757 9.32 NOD2 TNF
16 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.16 NOD2 TNF
17 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.13 BRAF NOD2 TNF
18 positive regulation of membrane protein ectodomain proteolysis GO:0051044 8.62 TNF TNFRSF1B

Molecular functions related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitogen-activated protein kinase kinase binding GO:0031434 8.62 ACE BRAF

Sources for Granulomatous Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....