MCID: GRN003
MIFTS: 31

Granulomatous Dermatitis malady

Summaries for Granulomatous Dermatitis

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33MalaCards
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MalaCards: Granulomatous Dermatitis is related to blau syndrome and ulcerative colitis. An important gene associated with Granulomatous Dermatitis is NOD2 (nucleotide-binding oligomerization domain containing 2), and among its related pathways are Toll-Like receptor Signaling Pathways and Leishmaniasis. The compounds prednisolone and il 10 have been mentioned in the context of this disorder. Affiliated tissues include thyroid, skin and t cells.

Aliases & Classifications for Granulomatous Dermatitis

Sources:
8Disease Ontology, 61UMLS, 40NCIt
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Aliases & Descriptions:

granulomatous dermatitis 8 61


External Ids:

Disease Ontology8 DOID:4397
NCIt40 C3505

Related Diseases for Granulomatous Dermatitis

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Granulomatous Dermatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 72)
idRelated DiseaseScoreTop Affiliating Genes
1blau syndrome30.2TNF, NOD2
2ulcerative colitis30.2TNF, NOD2
3spondylitis30.0NOD2
4ankylosing spondylitis30.0TNF, NOD2
5uveitis30.0NOD2, TNF, ACE
6arthritis10.7
7systemic lupus erythematosus10.4
8ackerman syndrome10.3
9cutaneous leishmaniasis10.3
10wells syndrome10.3
11granulomatous hepatitis10.2
12hepatitis d10.2
13hepatitis a10.2
14vasculitis10.2
15interstitial granulomatous dermatitis with arthritis10.2
16bullous pemphigoid10.0
17antiphospholipid syndrome10.0
18cystic fibrosis10.0
19pseudoxanthoma elasticum10.0
20autoimmune thyroiditis10.0
21hemophagocytic lymphohistiocytosis10.0
22cutis laxa10.0
23cutaneous lupus erythematosus10.0
24coccidioidomycosis10.0
25skin sarcoidosis10.0
26cellulitis10.0
27common variable immunodeficiency10.0
28silicosis10.0
29autoimmune hepatitis10.0
30churg-strauss syndrome10.0
31n syndrome10.0
32granuloma annulare10.0
33acute leukemia10.0
34thyroiditis10.0
35vascular disease10.0
36hemophagocytic lymphohistiocytosis, familial10.0
37acute promyelocytic leukemia10.0
38chronic inflammatory demyelinating polyneuropathy10.0
39erythema elevatum diutinum10.0
40lymphomatoid granulomatosis10.0
41spitz nevus10.0
42bacteremia10.0
43acquired cutis laxa10.0
44granulomatous mastitis10.0
45pauci-immune glomerulonephritis10.0
46peritonitis10.0TNF
47atopy10.0NOD2
48pouchitis10.0NOD2
49respiratory failure10.0TNF
50pyoderma gangrenosum10.0NOD2

Graphical network of the top 20 diseases related to Granulomatous Dermatitis:



Diseases related to granulomatous dermatitis

Clinical Features for Granulomatous Dermatitis

Drugs & Therapeutics for Granulomatous Dermatitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Granulomatous Dermatitis

Drug clinical trials:

Search ClinicalTrials for Granulomatous Dermatitis

Search NIH Clinical Center for Granulomatous Dermatitis

Search CenterWatch for Granulomatous Dermatitis

Genetic Tests for Granulomatous Dermatitis

Anatomical Context for Granulomatous Dermatitis

Sources:
33MalaCards
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MalaCards organs/tissues related to Granulomatous Dermatitis:

33
Thyroid, Skin, T cells

Animal Models for Granulomatous Dermatitis or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Granulomatous Dermatitis

Sources:
51PubMed
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Articles related to Granulomatous Dermatitis:

(show top 50)    (show all 136)
idTitleAuthorsYear
1
Crystal deodorant-induced axillary granulomatous dermatitis. (23621443)
2014
2
Ustekinumab therapy for severe interstitial granulomatous dermatitis with arthritis. (23677104)
2013
3
Perforating granulomatous dermatitis reaction to exogenous tattoo pigment: a case report and review of the literature. (21986232)
2013
4
Generalized Granulomatous Dermatitis Accompanied by Myelodysplastic Syndrome. (23817627)
2013
5
Granulomatous dermatitis related to silicone implant. (24364999)
2013
6
Palisaded neutrophilic and granulomatous dermatitis in an adolescent girl with perinuclear antineutrophil cytoplasmic antibody-positive pauci-immune glomerulonephritis and arthritis. (22980283)
2012
7
Images in clinical medicine. Palisaded neutrophilic and granulomatous dermatitis. (22646653)
2012
8
Granuloma annulare associated with cutaneous marginal zone lymphoma: a case linking a hematologic malignancy with granulomatous dermatitis. (22935889)
2012
9
Acute New World cutaneous leishmaniasis presenting as tuberculoid granulomatous dermatitis. (22236114)
2012
10
Allopurinol-induced palisaded neutrophilic and granulomatous dermatitis. (22250812)
2012
11
Autoimmune thyroiditis presenting as interstitial granulomatous dermatitis. (23044569)
2012
12
Interstitial granulomatous dermatitis in a patient with lupus erythematosus. (21986235)
2011
13
Interstitial granulomatous dermatitis: another clinical variant. (22087092)
2011
14
Interstitial granulomatous dermatitis in rheumatoid arthritis responsive to etanercept. (19802716)
2010
15
Necrotizing palisaded granulomatous dermatitis as a manifestation of familial hemophagocytic lymphohistiocytosis. (19903216)
2010
16
Interstitial granulomatous dermatitis with arthritis associated with trastuzumab. (19744176)
2010
17
Palisaded neutrophilic granulomatous dermatitis with leukocytoclastic vasculitis in a patient without any underlying systemic disease detected to date. (19903215)
2010
18
Palisaded neutrophilic granulomatous dermatitis in systemic lupus erythematosus with a butterfly rash-like lesion. (19822482)
2010
19
Interstitial granulomatous dermatitis with arthritis. (19891930)
2009
20
Localized acquired cutis laxa secondary to interstitial granulomatous dermatitis. (19438565)
2009
21
Birefringent particles in granulomatous dermatitis, sarcoidal-type, as well as in other non-granulomatous skin disorders in patients without sarcoidosis. (19634571)
2009
22
Granulomatous dermatitis with pseudoxanthoma elasticum-like changes: report of a case in a patient with cystic fibrosis. (19917959)
2009
23
Interstitial granulomatous dermatitis in a child with chronic uveitis. (18489032)
2008
24
Interstitial granulomatous dermatitis with plaques. (18841631)
2008
25
Delayed reaction after an octopus bite showing a giant cell-rich granulomatous dermatitis/panniculitis. (18544063)
2008
26
Interstitial granulomatous dermatitis associated with autoimmune hepatitis. (17447986)
2007
27
Perforating neutrophilic and granulomatous dermatitis of the newborn--a clue to immunodeficiency. (17542866)
2007
28
Erythema elevatum diutinum in the spectrum of palisaded neutrophilic granulomatous dermatitis: description of a case with rheumatoid arthritis. (17207177)
2007
29
Widespread granulomatous dermatitis of infancy: an early sign of Blau syndrome. (17372104)
2007
30
Interstitial granulomatous dermatitis associated with the use of tumor necrosis factor alpha inhibitors. (16490847)
2006
31
Palisaded neutrophilic granulomatous dermatitis in a 12-year-old girl with systemic lupus erythematosus. (16843132)
2006
32
Granulomatous dermatitis in common variable immunodeficiency with functional T-cell defect. (16785389)
2006
33
Palisaded neutrophilic granulomatous dermatitis presenting as an unusual skin manifestation in a patient with BehAset's disease. (16195168)
2005
34
Palisading neutrophilic granulomatous dermatitis in a Japanese patient with Wegener's granulomatosis. (16043926)
2005
35
Granulomatous rosacea mimicking eyelid dermatitis. (16394471)
2005
36
Adverse effects of cosmetic tattooing: an illustrative case of granulomatous dermatitis following the application of permanent makeup. (16027323)
2005
37
Interstitial granulomatous dermatitis with plaques associated with antiphospholipid syndrome. (15840129)
2005
38
Interstitial granulomatous dermatitis secondary to soy. (15280826)
2004
39
Interstitial granulomatous dermatitis with histiocytic pseudorosettes: a new histopathologic pattern in cutaneous borreliosis. Detection of Borrelia burgdorferi DNA sequences by a highly sensitive PCR-ELISA. (12637917)
2003
40
Interstitial granulomatous dermatitis with plaques and arthritis. (12804998)
2003
41
Interstitial granulomatous dermatitis associated with pulmonary coccidioidomycosis. (11712027)
2001
42
Lichenoid and granulomatous dermatitis. (10692062)
2000
43
A granulomatous dermatitis associated with idiopathic ulcerative colitis. (10759966)
2000
44
Granulomatous dermatitis with focal sarcoidal features associated with recombinant interferon beta-1b injections. (9843024)
1998
45
Interstitial granulomatous dermatitis with arthritis. (8647988)
1996
46
Granulomatous dermatitis after implantation of a titanium-containing pacemaker. (8706412)
1995
47
Granulomatous dermatitis and mastitis in two SPF rats associated with a slowly growing Staphylococcus aureus--a case report. (7603004)
1995
48
Granulomatous dermatitis in peach-faced lovebirds. (3426471)
1987
49
Idiopathic periadnexal multinodular granulomatous dermatitis in twenty-two dogs. (3824822)
1987
50
Wells' syndrome. Recurrent granulomatous dermatitis with eosinophilia. (443839)
1979

Genetic Variations for Granulomatous Dermatitis

Expression for genes affiliated with Granulomatous Dermatitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Granulomatous Dermatitis

Search GEO for disease gene expression data for Granulomatous Dermatitis.

Pathways for genes affiliated with Granulomatous Dermatitis

Sources:
53R&D Systems, 30KEGG, 38NCBI BioSystems Database, 54Reactome
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Compounds for genes affiliated with Granulomatous Dermatitis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB
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Compounds related to Granulomatous Dermatitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1prednisolone45 29 1111.6NOD2
2il 10459.4NOD2, TNF
3infliximab45 50 1111.4NOD2, TNF
4peptidoglycan45 2910.3NOD2, TNF
5prostacyclin459.1ACE, TNF
6nitric oxide45 11 2410.4TNF, NOD2, ACE

GO Terms for genes affiliated with Granulomatous Dermatitis

Sources:
16Gene Ontology
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Cellular components related to Granulomatous Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.1ACE, TNF

Biological processes related to Granulomatous Dermatitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of humoral immune response mediated by circulating immunoglobulinGO:0029259.6NOD2, TNF
2negative regulation of growth of symbiont in hostGO:0441309.5NOD2, TNF
3defense response to Gram-positive bacteriumGO:0508309.5TNF, NOD2
4positive regulation of interleukin-6 productionGO:0327559.5NOD2, TNF
5positive regulation of JNK cascadeGO:0463309.4NOD2, TNF
6JNK cascadeGO:0072549.4TNF, NOD2
7activation of MAPK activityGO:0001879.3NOD2, TNF
8positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431239.3NOD2, TNF
9positive regulation of ERK1 and ERK2 cascadeGO:0703749.2NOD2, TNF
10positive regulation of NF-kappaB transcription factor activityGO:0510929.0NOD2, TNF

Products for genes affiliated with Granulomatous Dermatitis

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Sources for Granulomatous Dermatitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet