MCID: GRN003
MIFTS: 33

Granulomatous Dermatitis malady

Skin diseases category

Summaries for Granulomatous Dermatitis

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MalaCards based summary: Granulomatous Dermatitis is related to arthritis and systemic lupus erythematosus. An important gene associated with Granulomatous Dermatitis is NOD2 (nucleotide-binding oligomerization domain containing 2), and among its related pathways are Leishmaniasis and Tuberculosis. The compounds il 10 and infliximab have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, skin and thyroid, and related mouse phenotypes are hematopoietic system and growth/size/body.

Aliases & Classifications for Granulomatous Dermatitis

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Granulomatous Dermatitis, Aliases & Descriptions:

Name: Granulomatous Dermatitis 9 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


External Ids:

Disease Ontology9 DOID:4397
NCIt38 C3505

Related Diseases for Granulomatous Dermatitis

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Diseases related to Granulomatous Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 71)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.1TNF, NOD2
2systemic lupus erythematosus30.7NOD2, TNF
3spondylitis30.6NOD2
4vascular disease30.6TNF
5colitis30.6TNF, NOD2
6ulcerative colitis30.5NOD2, TNF
7blau syndrome30.5TNF, NOD2
8uveitis29.7TNF, ACE, NOD2
9dermatitis11.1
10rheumatoid arthritis10.5
11lupus erythematosus10.5
12psoriatic arthritis10.4TNF
13eosinophilia10.4
14myelodysplastic syndrome10.3
15cutaneous leishmaniasis10.3
16leishmaniasis10.3
17wells syndrome10.3
18hepatitis10.2
19vasculitis10.2
20ackerman syndrome10.2
21iridogoniodysgenesis type110.2
22familial mediterranean fever, ar10.1NOD2, TNF
23acute graft versus host disease10.1TNF, NOD2
24spondyloarthropathy 110.1TNF, NOD2
25crohn's disease10.1NOD2, TNF
26arthropathy10.1NOD2, TNF
27atopic dermatitis10.1NOD2, TNF
28cystic fibrosis10.1
29pseudoxanthoma elasticum10.1
30bacteremia10.1
31anaplastic large cell lymphoma10.1
32autoimmune hepatitis10.1
33b-cell lymphomas10.1
34burns10.1
35chronic inflammatory demyelinating polyneuropathy10.1
36common variable immunodeficiency10.1
37diffuse large b-cell lymphoma10.1
38glomerulonephritis10.1
39granuloma annulare10.1
40hemophagocytic lymphohistiocytosis10.1
41leukemia10.1
42lymphomatoid granulomatosis10.1
43silicosis10.1
44autoimmune thyroiditis10.1
45antiphospholipid syndrome10.1
46bullous pemphigoid10.1
47churg-strauss syndrome10.1
48cutis laxa10.1
49coccidioidomycosis10.1
50cellulitis10.1

Graphical network of the top 20 diseases related to Granulomatous Dermatitis:



Diseases related to granulomatous dermatitis

Symptoms for Granulomatous Dermatitis

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Drugs & Therapeutics for Granulomatous Dermatitis

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Drug clinical trials:

Search ClinicalTrials for Granulomatous Dermatitis

Search NIH Clinical Center for Granulomatous Dermatitis

Genetic Tests for Granulomatous Dermatitis

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Anatomical Context for Granulomatous Dermatitis

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MalaCards organs/tissues related to Granulomatous Dermatitis:

31
Neutrophil, Skin, Thyroid, T cells, B cells

Animal Models for Granulomatous Dermatitis or affiliated genes

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MGI Mouse Phenotypes related to Granulomatous Dermatitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.5NOD2, ACE, TNF
2MP:00053788.5NOD2, ACE, TNF
3MP:00053878.4NOD2, ACE, TNF
4MP:00053848.2TNF, ACE, NOD2

Publications for Granulomatous Dermatitis

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Articles related to Granulomatous Dermatitis:

(show top 50)    (show all 144)
idTitleAuthorsYear
1
Interstitial Granulomatous Dermatitis Associated with Myelodysplastic Syndrome - Complete Clearance Under Therapy with 5-azacytidine. (24573709)
2014
2
Ustekinumab therapy for severe interstitial granulomatous dermatitis with arthritis. (23677104)
2013
3
Palisaded neutrophilic and granulomatous dermatitis in association with subcutaneous nodular and systemic sarcoidosis. (24476612)
2013
4
Perforating granulomatous dermatitis reaction to exogenous tattoo pigment: a case report and review of the literature. (21986232)
2013
5
Generalized Granulomatous Dermatitis Accompanied by Myelodysplastic Syndrome. (23817627)
2013
6
A palpable erythematous cord over the trunk in a patient with systemic lupus erythematosus. Interstitial granulomatous dermatitis (IGD). (23677093)
2013
7
Combination therapy with intralesional triamcinolone and oral dapsone for management of palisaded neutrophilic and granulomatous dermatitis. (23473287)
2013
8
Interstitial granulomatous dermatitis and arthritis revealing oesophageal carcinoma. (23777491)
2013
9
A cutaneous interstitial granulomatous dermatitis-like eruption arising in myelodysplasia with leukemic progression. (23221468)
2013
10
Interstitial granulomatous dermatitis with arthritis presenting with the rope sign. (23531209)
2013
11
Palisaded neutrophilic and granulomatous dermatitis in a rheumatoid arthritis patient after treatment with adalimumab. (24201093)
2013
12
Palisaded neutrophilic and granulomatous dermatitis in an adolescent girl with perinuclear antineutrophil cytoplasmic antibody-positive pauci-immune glomerulonephritis and arthritis. (22980283)
2012
13
Interstitial granulomatous dermatitis: a distinct entity with characteristic histological and clinical pattern. (22059717)
2012
14
Interstitial granulomatous dermatitis? An unusual presentation in the mucosa and periungual skin. (21352283)
2011
15
Interstitial granulomatous dermatitis in a patient with lupus erythematosus. (21986235)
2011
16
Isolated unilateral palisaded neutrophilic and granulomatous dermatitis. (21860170)
2011
17
Palisaded neutrophilic and granulomatous dermatitis in association with sarcoidosis. (20528967)
2011
18
Interstitial granulomatous dermatitis: another clinical variant. (22087092)
2011
19
Palisaded neutrophilic and granulomatous dermatitis: a presenting sign of sarcoidosis? (21839329)
2011
20
Palisaded neutrophilic granulomatous dermatitis without a definable underlying disorder treated with dapsone. (21839310)
2011
21
Interstitial granulomatous dermatitis in rheumatoid arthritis responsive to etanercept. (19802716)
2010
22
Necrotizing palisaded granulomatous dermatitis as a manifestation of familial hemophagocytic lymphohistiocytosis. (19903216)
2010
23
Interstitial granulomatous dermatitis in a patient with rheumatoid arthritis on etanercept. (19271571)
2009
24
Interstitial granulomatous dermatitis in a child with chronic uveitis. (18489032)
2008
25
Interstitial granulomatous dermatitis in a patient with rheumatoid arthritis on etanercept. (18491481)
2008
26
Interstitial granulomatous dermatitis: a misdiagnosed cutaneous form of systemic lupus erythematosus? (18681887)
2008
27
Early lesion of palisaded neutrophilic granulomatous dermatitis in ulcerative colitis. (17483043)
2007
28
Interstitial granulomatous dermatitis associated with autoimmune hepatitis. (17447986)
2007
29
Infliximab therapy for interstitial granulomatous dermatitis. (17243965)
2007
30
Perforating neutrophilic and granulomatous dermatitis of the newborn--a clue to immunodeficiency. (17542866)
2007
31
Lichenoid and granulomatous dermatitis associated with atypical mycobacterium infections. (16872476)
2006
32
Interstitial granulomatous dermatitis associated with the use of tumor necrosis factor alpha inhibitors. (16490847)
2006
33
Granulomatous dermatitis with enlarged histiocytes: a characteristic pattern of granulocyte colony-stimulating factor. Report of two cases and review of the literature. (16484826)
2006
34
Palisaded neutrophilic granulomatous dermatitis presenting as an unusual skin manifestation in a patient with BehAset's disease. (16195168)
2005
35
Palisaded neutrophilic and granulomatous dermatitis: an unusual cutaneous manifestation of immune-mediated disorders. (15609265)
2004
36
Interstitial granulomatous dermatitis with plaques and arthritis. (14579165)
2003
37
Interstitial granulomatous dermatitis with histiocytic pseudorosettes: a new histopathologic pattern in cutaneous borreliosis. Detection of Borrelia burgdorferi DNA sequences by a highly sensitive PCR-ELISA. (12637917)
2003
38
Interstitial granulomatous dermatitis with plaques and arthritis. (12804998)
2003
39
Photo quiz. Palisaded neutrophilic and granulomatous dermatitis with underlying Wegener's granulomatosis. (12184668)
2002
40
Interstitial granulomatous dermatitis with plaques. (12063487)
2002
41
Granulomatous dermatitis in a spadefoot toad (Scaphiopus holbrooki). (12189601)
2002
42
Lichenoid and granulomatous dermatitis. (10692062)
2000
43
The histopathologic spectrum of palisaded neutrophilic and granulomatous dermatitis in patients with collagen vascular disease. (7944509)
1994
44
Granulomatous dermatitis and Zyderm. (8016250)
1994
45
Granulomatous dermatitis to iron oxide after permanent pigmentation of the eyebrows. (8454784)
1993
46
Granulomatous dermatitis in peach-faced lovebirds. (3426471)
1987
47
Recurrent granulomatous dermatitis with eosinophilia. Wells' syndrome. (6724778)
1984
48
Periocular dermatitis: a micropapular sarcoid-like granulomatous dermatitis in a woman. (7250477)
1981
49
Wells' syndrome. Recurrent granulomatous dermatitis with eosinophilia. (443839)
1979
50
Lymphomatoid granulomatosis preceded by chronic granulomatous dermatitis. (718200)
1978

Variations for Granulomatous Dermatitis

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Expression for genes affiliated with Granulomatous Dermatitis

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Search GEO for disease gene expression data for Granulomatous Dermatitis.

Pathways for genes affiliated with Granulomatous Dermatitis

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Pathways related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3TNF, NOD2
29.3NOD2, TNF
3
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
9.3NOD2, TNF
49.3NOD2, TNF
5
Show member pathways
9.3NOD2, TNF
69.3NOD2, TNF
7
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.1ACE, TNF
8
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy36
9.1ACE, TNF

Compounds for genes affiliated with Granulomatous Dermatitis

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Sources:
43Novoseek, 49PharmGKB, 12DrugBank, 28IUPHAR, 24HMDB
See all sources

Compounds related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1il 10439.5NOD2, TNF
2infliximab43 49 1211.5NOD2, TNF
3peptidoglycan43 2810.5TNF, NOD2
4prednisolone43 28 1211.3TNF, NOD2
5tacrolimus43 49 1211.3NOD2, TNF
6endotoxin439.2NOD2, TNF
7atorvastatin43 49 28 24 1213.2TNF, ACE
8prostacyclin438.8ACE, TNF
9nitric oxide43 24 1210.6NOD2, ACE, TNF

GO Terms for genes affiliated with Granulomatous Dermatitis

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Cellular components related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099869.3NOD2, TNF
2external side of plasma membraneGO:00098978.8ACE, TNF

Biological processes related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of humoral immune response mediated by circulating immunoglobulinGO:00029259.6NOD2, TNF
2negative regulation of growth of symbiont in hostGO:00441309.5NOD2, TNF
3defense response to Gram-positive bacteriumGO:00508309.5TNF, NOD2
4positive regulation of interleukin-6 productionGO:00327559.5NOD2, TNF
5JNK cascadeGO:00072549.4NOD2, TNF
6positive regulation of JNK cascadeGO:00463309.4TNF, NOD2
7activation of MAPK activityGO:00001879.3NOD2, TNF
8positive regulation of I-kappaB kinase/NF-kappaB signalingGO:00431239.3NOD2, TNF
9positive regulation of ERK1 and ERK2 cascadeGO:00703749.2NOD2, TNF
10positive regulation of NF-kappaB transcription factor activityGO:00510929.0NOD2, TNF

Products for genes affiliated with Granulomatous Dermatitis

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Sources for Granulomatous Dermatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet