MCID: GRN003
MIFTS: 32

Granulomatous Dermatitis malady

Summaries for Granulomatous Dermatitis

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32MalaCards
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MalaCards: Granulomatous Dermatitis is related to dermatitis and rheumatoid arthritis. An important gene associated with Granulomatous Dermatitis is NOD2 (nucleotide-binding oligomerization domain containing 2), and among its related pathways are Toll-Like receptor Signaling Pathways and Leishmaniasis. The compounds prednisolone and il 10 have been mentioned in the context of this disorder. Affiliated tissues include skin, thyroid and t cells.

Aliases & Classifications for Granulomatous Dermatitis

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8Disease Ontology, 60UMLS, 39NCIt
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Aliases & Descriptions:

granulomatous dermatitis 8 60


External Ids:

Disease Ontology8 DOID:4397
NCIt39 C3505

Related Diseases for Granulomatous Dermatitis

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Granulomatous Dermatitis:



Diseases related to granulomatous dermatitis

Clinical Features for Granulomatous Dermatitis

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Drugs & Therapeutics for Granulomatous Dermatitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Granulomatous Dermatitis

Drug clinical trials:

Search ClinicalTrials for Granulomatous Dermatitis

Search NIH Clinical Center for Granulomatous Dermatitis

Search CenterWatch for Granulomatous Dermatitis

Genetic Tests for Granulomatous Dermatitis

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Anatomical Context for Granulomatous Dermatitis

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32MalaCards
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MalaCards organs/tissues related to Granulomatous Dermatitis:

32
Skin, Thyroid, T cells

Animal Models for Granulomatous Dermatitis or affiliated genes

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Publications for Granulomatous Dermatitis

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50PubMed
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Articles related to Granulomatous Dermatitis:

(show top 50)    (show all 136)
idTitleAuthorsYear
1
Ustekinumab therapy for severe interstitial granulomatous dermatitis with arthritis. (23677104)
2013
2
Perforating granulomatous dermatitis reaction to exogenous tattoo pigment: a case report and review of the literature. (21986232)
2013
3
Combination therapy with intralesional triamcinolone and oral dapsone for management of palisaded neutrophilic and granulomatous dermatitis. (23473287)
2013
4
Interstitial granulomatous dermatitis and arthritis revealing oesophageal carcinoma. (23777491)
2013
5
Interstitial granulomatous dermatitis with arthritis presenting with the rope sign. (23531209)
2013
6
Granulomatous dermatitis related to silicone implant. (24364999)
2013
7
Palisaded neutrophilic and granulomatous dermatitis in an adolescent girl with perinuclear antineutrophil cytoplasmic antibody-positive pauci-immune glomerulonephritis and arthritis. (22980283)
2012
8
Images in clinical medicine. Palisaded neutrophilic and granulomatous dermatitis. (22646653)
2012
9
Intravenous immunoglobulins as a treatment of interstitial granulomatous dermatitis with arthritis. (22283232)
2012
10
Allopurinol-induced palisaded neutrophilic and granulomatous dermatitis. (22250812)
2012
11
Interstitial granulomatous dermatitis with arthritis responding to tocilizumab. (22250229)
2012
12
Autoimmune thyroiditis presenting as interstitial granulomatous dermatitis. (23044569)
2012
13
Interstitial granulomatous dermatitis? An unusual presentation in the mucosa and periungual skin. (21352283)
2011
14
Interstitial granulomatous dermatitis in a patient with lupus erythematosus. (21986235)
2011
15
Interstitial granulomatous dermatitis: another clinical variant. (22087092)
2011
16
Palisaded neutrophilic and granulomatous dermatitis presenting in a patient with rheumatoid arthritis on adalimumab. (21592182)
2011
17
Interstitial granulomatous dermatitis in rheumatoid arthritis responsive to etanercept. (19802716)
2010
18
Interstitial granulomatous dermatitis with arthritis associated with trastuzumab. (19744176)
2010
19
Palisaded neutrophilic granulomatous dermatitis with leukocytoclastic vasculitis in a patient without any underlying systemic disease detected to date. (19903215)
2010
20
Interstitial granulomatous dermatitis with arthritis. (19891930)
2009
21
Granulomatous periorificial dermatitis: a variant of granulomatous rosacea in children? (19298782)
2009
22
Drug-induced hypersensitivity syndrome with superficial granulomatous dermatitis--a novel finding. (19590408)
2009
23
Palisaded neutrophilic granulomatous dermatitis associated with systemic lupus erythematosus presenting with the burning rope sign. (19577332)
2009
24
Palisaded neutrophilic and granulomatous dermatitis in a child with type I diabetes mellitus and coeliac disease. (18503597)
2008
25
Granulomatous dermatitis due to blepharopigmentation. (18211419)
2008
26
Interstitial granulomatous dermatitis with plaques. (18841631)
2008
27
Interstitial granulomatous dermatitis associated with darifenacin. (19112808)
2008
28
Interstitial granulomatous dermatitis. (18627754)
2008
29
Infliximab therapy for interstitial granulomatous dermatitis. (17243965)
2007
30
Perforating neutrophilic and granulomatous dermatitis of the newborn--a clue to immunodeficiency. (17542866)
2007
31
Erythema elevatum diutinum in the spectrum of palisaded neutrophilic granulomatous dermatitis: description of a case with rheumatoid arthritis. (17207177)
2007
32
Widespread granulomatous dermatitis of infancy: an early sign of Blau syndrome. (17372104)
2007
33
Lichenoid and granulomatous dermatitis associated with atypical mycobacterium infections. (16872476)
2006
34
Interstitial granulomatous dermatitis associated with the use of tumor necrosis factor alpha inhibitors. (16490847)
2006
35
Granulomatous dermatitis in common variable immunodeficiency with functional T-cell defect. (16785389)
2006
36
Equine herpesvirus 2-associated granulomatous dermatitis in a horse. (16846998)
2006
37
Non-infectious granulomatous dermatitis: a clinicopathological study. (17177935)
2006
38
Palisading neutrophilic granulomatous dermatitis in a Japanese patient with Wegener's granulomatosis. (16043926)
2005
39
Palisaded neutrophilic and granulomatous dermatitis: an unusual cutaneous manifestation of immune-mediated disorders. (15609265)
2004
40
Interstitial granulomatous dermatitis with arthritis. (15257538)
2004
41
Granulomatous dermatitis in a spadefoot toad (Scaphiopus holbrooki). (12189601)
2002
42
Palisaded neutrophilic granulomatous dermatitis in rheumatoid arthritis. (12140472)
2002
43
Sarcoidal foreign-body granulomatous dermatitis associated with ophthalmic drops. (9557788)
1998
44
Interstitial granulomatous dermatitis with arthritis. (8647988)
1996
45
Granulomatous dermatitis after implantation of a titanium-containing pacemaker. (8706412)
1995
46
The histopathologic spectrum of palisaded neutrophilic and granulomatous dermatitis in patients with collagen vascular disease. (7944509)
1994
47
Perioral dermatitis with histopathologic features of granulomatous rosacea: successful treatment with isotretinoin. (2148143)
1990
48
Idiopathic periadnexal multinodular granulomatous dermatitis in twenty-two dogs. (3824822)
1987
49
Wells' syndrome. Recurrent granulomatous dermatitis with eosinophilia. (443839)
1979
50
Lymphomatoid granulomatosis preceded by chronic granulomatous dermatitis. (718200)
1978

Genetic Variations for Granulomatous Dermatitis

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Expression for genes affiliated with Granulomatous Dermatitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Granulomatous Dermatitis

Search GEO for disease gene expression data for Granulomatous Dermatitis.

Pathways for genes affiliated with Granulomatous Dermatitis

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Sources:
52R&D Systems, 29KEGG, 37NCBI BioSystems Database, 53Reactome
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Compounds for genes affiliated with Granulomatous Dermatitis

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Granulomatous Dermatitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1prednisolone44 28 1111.6NOD2
2il 10449.4NOD2, TNF
3infliximab44 49 1111.4NOD2, TNF
4peptidoglycan44 2810.3NOD2, TNF
5prostacyclin449.1ACE, TNF
6nitric oxide44 11 2410.4TNF, NOD2, ACE

GO Terms for genes affiliated with Granulomatous Dermatitis

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16Gene Ontology
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Cellular components related to Granulomatous Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.1ACE, TNF

Biological processes related to Granulomatous Dermatitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of humoral immune response mediated by circulating immunoglobulinGO:0029259.6NOD2, TNF
2negative regulation of growth of symbiont in hostGO:0441309.5NOD2, TNF
3defense response to Gram-positive bacteriumGO:0508309.5TNF, NOD2
4positive regulation of interleukin-6 productionGO:0327559.5NOD2, TNF
5positive regulation of JNK cascadeGO:0463309.4NOD2, TNF
6JNK cascadeGO:0072549.4TNF, NOD2
7activation of MAPK activityGO:0001879.3NOD2, TNF
8positive regulation of I-kappaB kinase/NF-kappaB cascadeGO:0431239.3NOD2, TNF
9positive regulation of ERK1 and ERK2 cascadeGO:0703749.2NOD2, TNF
10positive regulation of NF-kappaB transcription factor activityGO:0510929.0NOD2, TNF

Products for genes affiliated with Granulomatous Dermatitis

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Sources for Granulomatous Dermatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet