MCID: GRN003
MIFTS: 39

Granulomatous Dermatitis malady

Skin diseases category
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Summaries for Granulomatous Dermatitis

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MalaCards based summary: Granulomatous Dermatitis is related to arthritis and systemic lupus erythematosus. An important gene associated with Granulomatous Dermatitis is NOD2 (nucleotide-binding oligomerization domain containing 2), and among its related pathways are Leishmaniasis and Tuberculosis. The compounds il 10 and infliximab have been mentioned in the context of this disorder. Affiliated tissues include neutrophil, skin and thyroid, and related mouse phenotypes are hematopoietic system and growth/size/body.

Aliases & Classifications for Granulomatous Dermatitis

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Granulomatous Dermatitis, Aliases & Descriptions:

Name: Granulomatous Dermatitis 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


External Ids:

Disease Ontology8 DOID:4397
NCIt39 C3505

Related Diseases for Granulomatous Dermatitis

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Diseases related to Granulomatous Dermatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 71)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis31.1TNF, NOD2
2systemic lupus erythematosus30.7NOD2, TNF
3spondylitis30.6NOD2
4vascular disease30.6TNF
5colitis30.6TNF, NOD2
6ulcerative colitis30.6TNF, NOD2
7blau syndrome30.5NOD2, TNF
8ankylosing spondylitis30.3TNF, NOD2
9sarcoidosis30.2ACE, TNF, NOD2
10diabetes mellitus29.8ACE, TNF
11uveitis29.8NOD2, ACE, TNF
12dermatitis11.1
13interstitial granulomatous dermatitis with arthritis10.6
14rheumatoid arthritis10.5
15lupus erythematosus10.5
16psoriatic arthritis10.4TNF
17eosinophilia10.4
18cutaneous leishmaniasis10.3
19myelodysplastic syndromes10.3
20leishmaniasis10.3
21wells syndrome10.3
22hepatitis10.2
23wegener's granulomatosis10.2
24vasculitis10.2
25ackerman syndrome10.2
26familial mediterranean fever10.1NOD2, TNF
27acute graft versus host disease10.1TNF, NOD2
28crohn's disease10.1TNF, NOD2
29arthropathy10.1TNF, NOD2
30atopic dermatitis10.1TNF, NOD2
31sepsis10.1TNF, NOD2
32inflammatory bowel disease10.1TNF, NOD2
33tuberculosis10.1TNF, NOD2
34anaplastic large cell lymphoma10.1
35autoimmune hepatitis10.1
36burns10.1
37chronic inflammatory demyelinating polyneuropathy10.1
38common variable immunodeficiency10.1
39cystic fibrosis10.1
40glomerulonephritis10.1
41granuloma annulare10.1
42leukemia10.1
43lymphomatoid granulomatosis10.1
44silicosis10.1
45autoimmune thyroiditis10.1
46pseudoxanthoma elasticum10.1
47antiphospholipid syndrome10.1
48coccidioidomycosis10.1
49bullous pemphigoid10.1
50churg-strauss syndrome10.1

Graphical network of the top 20 diseases related to Granulomatous Dermatitis:



Diseases related to granulomatous dermatitis

Symptoms for Granulomatous Dermatitis

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Drugs & Therapeutics for Granulomatous Dermatitis

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Drug clinical trials:

Search ClinicalTrials for Granulomatous Dermatitis

Search NIH Clinical Center for Granulomatous Dermatitis

Genetic Tests for Granulomatous Dermatitis

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Anatomical Context for Granulomatous Dermatitis

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MalaCards organs/tissues related to Granulomatous Dermatitis:

32
Neutrophil, Skin, Thyroid, T cells

Animal Models for Granulomatous Dermatitis or affiliated genes

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MGI Mouse Phenotypes related to Granulomatous Dermatitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053978.5NOD2, ACE, TNF
2MP:00053788.5NOD2, ACE, TNF
3MP:00053878.4NOD2, ACE, TNF
4MP:00053848.2TNF, ACE, NOD2

Publications for Granulomatous Dermatitis

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Articles related to Granulomatous Dermatitis:

(show top 50)    (show all 136)
idTitleAuthorsYear
1
Interstitial Granulomatous Dermatitis Associated with Myelodysplastic Syndrome - Complete Clearance Under Therapy with 5-azacytidine. (24573709)
2014
2
Ustekinumab therapy for severe interstitial granulomatous dermatitis with arthritis. (23677104)
2013
3
Palisaded neutrophilic and granulomatous dermatitis in association with subcutaneous nodular and systemic sarcoidosis. (24476612)
2013
4
Perforating granulomatous dermatitis reaction to exogenous tattoo pigment: a case report and review of the literature. (21986232)
2013
5
Generalized Granulomatous Dermatitis Accompanied by Myelodysplastic Syndrome. (23817627)
2013
6
A palpable erythematous cord over the trunk in a patient with systemic lupus erythematosus. Interstitial granulomatous dermatitis (IGD). (23677093)
2013
7
Combination therapy with intralesional triamcinolone and oral dapsone for management of palisaded neutrophilic and granulomatous dermatitis. (23473287)
2013
8
Interstitial granulomatous dermatitis and arthritis revealing oesophageal carcinoma. (23777491)
2013
9
A cutaneous interstitial granulomatous dermatitis-like eruption arising in myelodysplasia with leukemic progression. (23221468)
2013
10
Interstitial granulomatous dermatitis with arthritis presenting with the rope sign. (23531209)
2013
11
Palisaded neutrophilic and granulomatous dermatitis in a rheumatoid arthritis patient after treatment with adalimumab. (24201093)
2013
12
Palisaded neutrophilic and granulomatous dermatitis in an adolescent girl with perinuclear antineutrophil cytoplasmic antibody-positive pauci-immune glomerulonephritis and arthritis. (22980283)
2012
13
Interstitial granulomatous dermatitis: a distinct entity with characteristic histological and clinical pattern. (22059717)
2012
14
Images in clinical medicine. Palisaded neutrophilic and granulomatous dermatitis. (22646653)
2012
15
Interstitial granulomatous dermatitis? An unusual presentation in the mucosa and periungual skin. (21352283)
2011
16
Interstitial granulomatous dermatitis in a patient with lupus erythematosus. (21986235)
2011
17
Isolated unilateral palisaded neutrophilic and granulomatous dermatitis. (21860170)
2011
18
Palisaded neutrophilic and granulomatous dermatitis in association with sarcoidosis. (20528967)
2011
19
Interstitial granulomatous dermatitis: another clinical variant. (22087092)
2011
20
Palisaded neutrophilic and granulomatous dermatitis: a presenting sign of sarcoidosis? (21839329)
2011
21
Palisaded neutrophilic granulomatous dermatitis without a definable underlying disorder treated with dapsone. (21839310)
2011
22
Interstitial granulomatous dermatitis in rheumatoid arthritis responsive to etanercept. (19802716)
2010
23
Interstitial granulomatous dermatitis in a patient with rheumatoid arthritis on etanercept. (19271571)
2009
24
Interstitial granulomatous dermatitis in a child with chronic uveitis. (18489032)
2008
25
Interstitial granulomatous dermatitis in a patient with rheumatoid arthritis on etanercept. (18491481)
2008
26
Interstitial granulomatous dermatitis: a misdiagnosed cutaneous form of systemic lupus erythematosus? (18681887)
2008
27
Early lesion of palisaded neutrophilic granulomatous dermatitis in ulcerative colitis. (17483043)
2007
28
Interstitial granulomatous dermatitis associated with autoimmune hepatitis. (17447986)
2007
29
Infliximab therapy for interstitial granulomatous dermatitis. (17243965)
2007
30
Perforating neutrophilic and granulomatous dermatitis of the newborn--a clue to immunodeficiency. (17542866)
2007
31
Lichenoid and granulomatous dermatitis associated with atypical mycobacterium infections. (16872476)
2006
32
Interstitial granulomatous dermatitis associated with the use of tumor necrosis factor alpha inhibitors. (16490847)
2006
33
Granulomatous dermatitis with enlarged histiocytes: a characteristic pattern of granulocyte colony-stimulating factor. Report of two cases and review of the literature. (16484826)
2006
34
Palisaded neutrophilic granulomatous dermatitis presenting as an unusual skin manifestation in a patient with BehAset's disease. (16195168)
2005
35
Palisaded neutrophilic and granulomatous dermatitis: an unusual cutaneous manifestation of immune-mediated disorders. (15609265)
2004
36
Interstitial granulomatous dermatitis with plaques and arthritis. (14579165)
2003
37
Interstitial granulomatous dermatitis with histiocytic pseudorosettes: a new histopathologic pattern in cutaneous borreliosis. Detection of Borrelia burgdorferi DNA sequences by a highly sensitive PCR-ELISA. (12637917)
2003
38
Interstitial granulomatous dermatitis with plaques and arthritis. (12804998)
2003
39
Photo quiz. Palisaded neutrophilic and granulomatous dermatitis with underlying Wegener's granulomatosis. (12184668)
2002
40
Interstitial granulomatous dermatitis with plaques. (12063487)
2002
41
Granulomatous dermatitis in a spadefoot toad (Scaphiopus holbrooki). (12189601)
2002
42
Lichenoid and granulomatous dermatitis. (10692062)
2000
43
The histopathologic spectrum of palisaded neutrophilic and granulomatous dermatitis in patients with collagen vascular disease. (7944509)
1994
44
Granulomatous dermatitis and Zyderm. (8016250)
1994
45
Granulomatous dermatitis to iron oxide after permanent pigmentation of the eyebrows. (8454784)
1993
46
Granulomatous dermatitis in peach-faced lovebirds. (3426471)
1987
47
Recurrent granulomatous dermatitis with eosinophilia. Wells' syndrome. (6724778)
1984
48
Periocular dermatitis: a micropapular sarcoid-like granulomatous dermatitis in a woman. (7250477)
1981
49
Wells' syndrome. Recurrent granulomatous dermatitis with eosinophilia. (443839)
1979
50
Lymphomatoid granulomatosis preceded by chronic granulomatous dermatitis. (718200)
1978

Variations for Granulomatous Dermatitis

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Expression for genes affiliated with Granulomatous Dermatitis

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Expression patterns in normal tissues for genes affiliated with Granulomatous Dermatitis

Search GEO for disease gene expression data for Granulomatous Dermatitis.

Pathways for genes affiliated with Granulomatous Dermatitis

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Pathways related to Granulomatous Dermatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.3TNF, NOD2
29.3NOD2, TNF
3
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
9.3NOD2, TNF
49.3NOD2, TNF
5
Show member pathways
9.3NOD2, TNF
69.3NOD2, TNF
7
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.1ACE, TNF
8
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
9.1ACE, TNF

Compounds for genes affiliated with Granulomatous Dermatitis

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Sources:
44Novoseek, 50PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB
See all sources

Compounds related to Granulomatous Dermatitis according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1il 10449.5NOD2, TNF
2infliximab44 50 1111.5NOD2, TNF
3peptidoglycan44 2810.5TNF, NOD2
4prednisolone44 28 1111.3TNF, NOD2
5tacrolimus44 50 1111.3NOD2, TNF
6endotoxin449.2NOD2, TNF
7atorvastatin44 50 28 24 1113.2TNF, ACE
8prostacyclin448.8ACE, TNF
9nitric oxide44 24 1110.6NOD2, ACE, TNF

GO Terms for genes affiliated with Granulomatous Dermatitis

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Cellular components related to Granulomatous Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099869.3NOD2, TNF
2external side of plasma membraneGO:0098978.8ACE, TNF

Biological processes related to Granulomatous Dermatitis according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of humoral immune response mediated by circulating immunoglobulinGO:0029259.6NOD2, TNF
2negative regulation of growth of symbiont in hostGO:0441309.5NOD2, TNF
3defense response to Gram-positive bacteriumGO:0508309.5TNF, NOD2
4positive regulation of interleukin-6 productionGO:0327559.5NOD2, TNF
5JNK cascadeGO:0072549.4NOD2, TNF
6positive regulation of JNK cascadeGO:0463309.4TNF, NOD2
7activation of MAPK activityGO:0001879.3NOD2, TNF
8positive regulation of I-kappaB kinase/NF-kappaB signalingGO:0431239.3NOD2, TNF
9positive regulation of ERK1 and ERK2 cascadeGO:0703749.2NOD2, TNF
10positive regulation of NF-kappaB transcription factor activityGO:0510929.0NOD2, TNF

Products for genes affiliated with Granulomatous Dermatitis

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Sources for Granulomatous Dermatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet