MCID: GRN003
MIFTS: 33

Granulomatous Dermatitis malady

Skin diseases category

Aliases & Classifications for Granulomatous Dermatitis

About this section

Aliases & Descriptions for Granulomatous Dermatitis:

Name: Granulomatous Dermatitis 10 12 65


Classifications:



External Ids:

Disease Ontology10 DOID:4397
NCIt42 C3505

Summaries for Granulomatous Dermatitis

About this section
MalaCards based summary: Granulomatous Dermatitis is related to systemic lupus erythematosus and cutaneous leishmaniasis. An important gene associated with Granulomatous Dermatitis is NOD2 (Nucleotide-Binding Oligomerization Domain Containing 2), and among its related pathways are Canonical NF-kappaB pathway and Adipocytokine signaling pathway. Affiliated tissues include neutrophil, skin and b cells, and related mouse phenotypes are renal/urinary system and muscle.

Related Diseases for Granulomatous Dermatitis

About this section

Diseases related to Granulomatous Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1systemic lupus erythematosus30.2TNF, TNFRSF1B, TREX1
2cutaneous leishmaniasis30.1NOD2, TNF, TNFRSF1B
3dermatitis11.2
4arthritis10.8
5interstitial granulomatous dermatitis with arthritis10.6
6rheumatoid arthritis10.5
7lupus erythematosus10.5
8eosinophilia10.4
9myelodysplastic syndrome10.3
10ulcerative colitis10.3
11colitis10.3
12leishmaniasis10.3
13wells syndrome10.3
14blau syndrome10.2
15hepatitis10.2
16coccidioidomycosis10.2
17vasculitis10.2
18ackerman syndrome10.2
19congenital nasal pyriform aperture stenosis with holoprosencephaly10.2ACE, TNF
20posterior valve urethra10.2ACE, TNF
21ischemic optic neuropathy10.2ACE, TNF
22eye accommodation disease10.1ACE, TNF
23baritosis10.1ACE, TNF
24intracranial primitive neuroectodermal tumor10.1NOD2, TNF
25emphysematous cholecystitis10.1ACE, TNF
26pneumonic tularemia10.1NOD2, TNF
27adult t-cell leukemia10.1ACE, TNF
28cervical adenoid basal carcinoma10.1ACE, TNF
29capillary lymphangioma10.1NOD2, TNF
30hidradenoma10.1NOD2, TNF
31pyrimidine metabolic disorder10.1NOD2, TNF
32petrositis10.1NOD2, TNF
33single ventricular heart10.1ACE, TNF
34diversion colitis10.1NOD2, TNF
35renal oncocytoma10.1ACE, TNF
36acute leukemia of ambiguous lineage10.1NOD2, TNF
37nodular malignant melanoma10.1ACE, TNF
38distal biliary tract carcinoma10.1TNF, TREX1
39sarcoidosis, early-onset10.1NOD2, TNF
40fallopian tube leiomyoma10.1ACE, TNF
41sleep disorder10.1ACE, TNF
42epidermolysis bullosa dystrophica10.1ACE, TNF
43bacteremia10.1
44cystic fibrosis10.1
45pseudoxanthoma elasticum10.1
46autoimmune hepatitis10.1
47b-cell lymphomas10.1
48burns10.1
49chronic inflammatory demyelinating polyneuropathy10.1
50common variable immunodeficiency10.1

Graphical network of the top 20 diseases related to Granulomatous Dermatitis:



Diseases related to granulomatous dermatitis

Symptoms for Granulomatous Dermatitis

About this section

Drugs & Therapeutics for Granulomatous Dermatitis

About this section

Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Granulomatous Dermatitis

Genetic Tests for Granulomatous Dermatitis

About this section

Anatomical Context for Granulomatous Dermatitis

About this section

MalaCards organs/tissues related to Granulomatous Dermatitis:

33
Neutrophil, Skin, B cells, T cells, Thyroid

Animal Models for Granulomatous Dermatitis or affiliated genes

About this section

MGI Mouse Phenotypes related to Granulomatous Dermatitis:

38 (show all 14)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053678.3ACE, FOXC1, TNFRSF1B, TREX1
2MP:00053698.3FOXC1, TNF, TNFRSF1B, TREX1
3MP:00053918.2FOXC1, TNF, TNFRSF1B, TREX1
4MP:00053888.1FOXC1, TNF, TNFRSF1B, TREX1
5MP:00053817.9FOXC1, NOD2, TNF, TNFRSF1B, TREX1
6MP:00053707.9ACE, FOXC1, TNF, TNFRSF1B, TREX1
7MP:00053857.8ACE, FOXC1, TNF, TNFRSF1B, TREX1
8MP:00053877.7ACE, NOD2, TNF, TNFRSF1B, TREX1
9MP:00053977.6ACE, NOD2, TNF, TNFRSF1B, TREX1
10MP:00053847.4ACE, FOXC1, NOD2, TNF, TNFRSF1B, TREX1
11MP:00107687.3ACE, FOXC1, NOD2, TNF, TNFRSF1B, TREX1
12MP:00053767.2ACE, FOXC1, NOD2, TNF, TNFRSF1B, TREX1

Publications for Granulomatous Dermatitis

About this section

Articles related to Granulomatous Dermatitis:

(show top 50)    (show all 150)
idTitleAuthorsYear
1
Interstitial Granulomatous Dermatitis as the Initial Manifestation of Myeloma. (26039702)
2015
2
Chronic Interstitial Granulomatous Dermatitis in Coccidioidomycosis. (26574343)
2015
3
Interstitial granulomatous dermatitis: rare cutaneous manifestation of rheumatoid arthritis. (26131871)
2015
4
Interstitial Granulomatous Dermatitis Associated with Myelodysplastic Syndrome - Complete Clearance Under Therapy with 5-azacytidine. (24573709)
2014
5
Ustekinumab therapy for severe interstitial granulomatous dermatitis with arthritis. (23677104)
2013
6
Palisaded neutrophilic and granulomatous dermatitis in association with subcutaneous nodular and systemic sarcoidosis. (24476612)
2013
7
Perforating granulomatous dermatitis reaction to exogenous tattoo pigment: a case report and review of the literature. (21986232)
2013
8
Generalized Granulomatous Dermatitis Accompanied by Myelodysplastic Syndrome. (23817627)
2013
9
A palpable erythematous cord over the trunk in a patient with systemic lupus erythematosus. Interstitial granulomatous dermatitis (IGD). (23677093)
2013
10
Combination therapy with intralesional triamcinolone and oral dapsone for management of palisaded neutrophilic and granulomatous dermatitis. (23473287)
2013
11
Interstitial granulomatous dermatitis and arthritis revealing oesophageal carcinoma. (23777491)
2013
12
A cutaneous interstitial granulomatous dermatitis-like eruption arising in myelodysplasia with leukemic progression. (23221468)
2013
13
Interstitial granulomatous dermatitis with arthritis presenting with the rope sign. (23531209)
2013
14
Palisaded neutrophilic and granulomatous dermatitis in a rheumatoid arthritis patient after treatment with adalimumab. (24201093)
2013
15
Palisaded neutrophilic and granulomatous dermatitis in an adolescent girl with perinuclear antineutrophil cytoplasmic antibody-positive pauci-immune glomerulonephritis and arthritis. (22980283)
2012
16
Interstitial granulomatous dermatitis: a distinct entity with characteristic histological and clinical pattern. (22059717)
2012
17
Interstitial granulomatous dermatitis? An unusual presentation in the mucosa and periungual skin. (21352283)
2011
18
Interstitial granulomatous dermatitis in a patient with lupus erythematosus. (21986235)
2011
19
Isolated unilateral palisaded neutrophilic and granulomatous dermatitis. (21860170)
2011
20
Palisaded neutrophilic and granulomatous dermatitis in association with sarcoidosis. (20528967)
2011
21
Interstitial granulomatous dermatitis: another clinical variant. (22087092)
2011
22
Palisaded neutrophilic and granulomatous dermatitis: a presenting sign of sarcoidosis? (21839329)
2011
23
Palisaded neutrophilic granulomatous dermatitis without a definable underlying disorder treated with dapsone. (21839310)
2011
24
Interstitial granulomatous dermatitis in rheumatoid arthritis responsive to etanercept. (19802716)
2010
25
Necrotizing palisaded granulomatous dermatitis as a manifestation of familial hemophagocytic lymphohistiocytosis. (19903216)
2010
26
Interstitial granulomatous dermatitis in a patient with rheumatoid arthritis on etanercept. (19271571)
2009
27
Interstitial granulomatous dermatitis in a child with chronic uveitis. (18489032)
2008
28
Interstitial granulomatous dermatitis in a patient with rheumatoid arthritis on etanercept. (18491481)
2008
29
Interstitial granulomatous dermatitis: a misdiagnosed cutaneous form of systemic lupus erythematosus? (18681887)
2008
30
Early lesion of palisaded neutrophilic granulomatous dermatitis in ulcerative colitis. (17483043)
2007
31
Interstitial granulomatous dermatitis associated with autoimmune hepatitis. (17447986)
2007
32
Infliximab therapy for interstitial granulomatous dermatitis. (17243965)
2007
33
Perforating neutrophilic and granulomatous dermatitis of the newborn--a clue to immunodeficiency. (17542866)
2007
34
Lichenoid and granulomatous dermatitis associated with atypical mycobacterium infections. (16872476)
2006
35
Interstitial granulomatous dermatitis associated with the use of tumor necrosis factor alpha inhibitors. (16490847)
2006
36
Granulomatous dermatitis with enlarged histiocytes: a characteristic pattern of granulocyte colony-stimulating factor. Report of two cases and review of the literature. (16484826)
2006
37
Palisaded neutrophilic granulomatous dermatitis presenting as an unusual skin manifestation in a patient with BehAset's disease. (16195168)
2005
38
Interstitial granulomatous dermatitis with plaques and arthritis. (14579165)
2003
39
Interstitial granulomatous dermatitis with histiocytic pseudorosettes: a new histopathologic pattern in cutaneous borreliosis. Detection of Borrelia burgdorferi DNA sequences by a highly sensitive PCR-ELISA. (12637917)
2003
40
Interstitial granulomatous dermatitis with plaques and arthritis. (12804998)
2003
41
Photo quiz. Palisaded neutrophilic and granulomatous dermatitis with underlying Wegener's granulomatosis. (12184668)
2002
42
Interstitial granulomatous dermatitis with plaques. (12063487)
2002
43
Lichenoid and granulomatous dermatitis. (10692062)
2000
44
The histopathologic spectrum of palisaded neutrophilic and granulomatous dermatitis in patients with collagen vascular disease. (7944509)
1994
45
Granulomatous dermatitis and Zyderm. (8016250)
1994
46
Granulomatous dermatitis to iron oxide after permanent pigmentation of the eyebrows. (8454784)
1993
47
Granulomatous dermatitis in peach-faced lovebirds. (3426471)
1987
48
Recurrent granulomatous dermatitis with eosinophilia. Wells' syndrome. (6724778)
1984
49
Periocular dermatitis: a micropapular sarcoid-like granulomatous dermatitis in a woman. (7250477)
1981
50
Wells' syndrome. Recurrent granulomatous dermatitis with eosinophilia. (443839)
1979

Variations for Granulomatous Dermatitis

About this section

Expression for genes affiliated with Granulomatous Dermatitis

About this section
Search GEO for disease gene expression data for Granulomatous Dermatitis.

Pathways for genes affiliated with Granulomatous Dermatitis

About this section

GO Terms for genes affiliated with Granulomatous Dermatitis

About this section

Biological processes related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of humoral immune response mediated by circulating immunoglobulinGO:000292510.1NOD2, TNF
2positive regulation of NIK/NF-kappaB signalingGO:190122410.1NOD2, TNF
3positive regulation of interleukin-8 productionGO:00327579.9NOD2, TNF
4negative regulation of growth of symbiont in hostGO:00441309.7NOD2, TNF
5positive regulation of interleukin-6 productionGO:00327559.7NOD2, TNF
6positive regulation of phagocytosisGO:00507669.7NOD2, TNF
7positive regulation of membrane protein ectodomain proteolysisGO:00510449.6TNF, TNFRSF1B
8extrinsic apoptotic signaling pathwayGO:00971919.6TNF, TNFRSF1B
9positive regulation of JNK cascadeGO:00463309.5NOD2, TNF
10blood vessel remodelingGO:00019749.5ACE, FOXC1
11defense response to Gram-positive bacteriumGO:00508309.4NOD2, TNF
12intrinsic apoptotic signaling pathway in response to DNA damageGO:00086309.4TNF, TNFRSF1B
13JNK cascadeGO:00072549.2NOD2, TNF

Sources for Granulomatous Dermatitis

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet