MCID: GRN003
MIFTS: 31

Granulomatous Dermatitis malady

Category: Skin diseases

Aliases & Classifications for Granulomatous Dermatitis

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Aliases & Descriptions for Granulomatous Dermatitis:

Name: Granulomatous Dermatitis 11 13 68

Classifications:



External Ids:

Disease Ontology11 DOID:4397
NCIt45 C3505

Summaries for Granulomatous Dermatitis

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MalaCards based summary: Granulomatous Dermatitis is related to interstitial granulomatous dermatitis with arthritis and dermatitis. An important gene associated with Granulomatous Dermatitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways are Canonical NF-kappaB pathway and TNF signaling pathway. Affiliated tissues include neutrophil, skin and b cells, and related mouse phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and digestive/alimentary.

Related Diseases for Granulomatous Dermatitis

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Diseases related to Granulomatous Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 106)
idRelated DiseaseScoreTop Affiliating Genes
1interstitial granulomatous dermatitis with arthritis12.1
2dermatitis10.7
3arthritis10.3
4amyotrophic lateral sclerosis type 510.1NOD2, TNF
5psoriatic arthritis10.1NOD2, TNF
6female reproductive system disease10.1NOD2, TNF
7amyotrophic lateral sclerosis type 1410.1NOD2, TNF
8parkinson disease 1110.1NOD2, TNF
9meier-gorlin syndrome 310.1NOD2, TNF
10leptospirosis10.1NOD2, TNF
11malignant histiocytosis10.1NOD2, TNF
12histiocytoma10.1NOD2, TNF
13functional gastric disease10.1NOD2, TNF
14acute myeloid leukemia with recurrent genetic anomaly10.1NOD2, TNF
15crohn's colitis10.1NOD2, TNF
16central bilateral macrogyria10.1FOXC1, TNF
17celiac disease10.1NOD2, TNF
18benign eccrine breast spiradenoma10.1NOD2, TNF
19endobronchial leiomyoma10.1NOD2, TNF
20uterine ligament clear cell adenocarcinoma10.1NOD2, TNF
21esophageal candidiasis10.0NOD2, TNF
22rheumatoid arthritis10.0
23lupus erythematosus10.0
24systemic lupus erythematosus10.0
25severe hemophilia a10.0ACE, TNF
26cardiac sarcoidosis10.0ACE, TNF
27preaxial polydactyly of fingers10.0ACE, TNF
28juvenile amyotrophic lateral sclerosis with dementia10.0ACE, TNF
29joint disorders10.0ACE, TNF
30atrial septal defect 610.0NOD2, TNF
31tuberculosis10.0ACE, TNF
32peripheral artery disease10.0ACE, TNF
33alcoholic hepatitis10.0ACE, TNF
34oppositional defiant disorder10.0ACE, TNF
35choroiditis10.0ACE, TNF
36skin conditions10.0ACE, TNF
37retinal ischemia10.0ACE, TNF
38pyelonephritis10.0ACE, TNF
39limb ischemia9.9ACE, TNF
40familial nephrotic syndrome9.9ACE, TNF
41diabetic encephalopathy9.9ACE, TNF
42microscopic breast papilloma9.9ACE, TNF
43biliary cirrhosis, primary, 29.9ACE, TNF
44acute chest syndrome9.9ACE, TNF
45anogenital venereal wart9.9ACE, TNF
46calcinosis9.8ACE, TNF
47newcastle disease9.8ACE, NOD2, TNF
48deafness, autosomal recessive 679.8ACE, NOD2, TNF
49myelodysplastic syndrome9.8
50cutaneous leishmaniasis9.8

Graphical network of the top 20 diseases related to Granulomatous Dermatitis:



Diseases related to granulomatous dermatitis

Symptoms & Phenotypes for Granulomatous Dermatitis

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GenomeRNAi Phenotypes related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00250-A-18.1ACE, BRAF, NOD2, TNF

MGI Mouse Phenotypes related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.2BRAF, FOXC1, NOD2, TNF
2MP:00053708.8ACE, BRAF, FOXC1, TNF
3MP:00053898.7ACE, BRAF, FOXC1, TNF
4MP:00053788.4ACE, BRAF, FOXC1, NOD2, TNF
5MP:00053768.3ACE, BRAF, FOXC1, NOD2, TNF

Drugs & Therapeutics for Granulomatous Dermatitis

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Granulomatous Dermatitis

Genetic Tests for Granulomatous Dermatitis

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Anatomical Context for Granulomatous Dermatitis

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MalaCards organs/tissues related to Granulomatous Dermatitis:

36
Neutrophil, Skin, B cells, T cells, Thyroid

Publications for Granulomatous Dermatitis

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Articles related to Granulomatous Dermatitis:

(show top 50)    (show all 168)
idTitleAuthorsYear
1
Postherpetic Granulomatous Dermatitis in a Man Treated With Nivolumab. (28532783)
2017
2
Papulonodular mucinosis with interstitial granulomatous dermatitis-like histological changes in a male patient with systemic lupus erythematosus. (27421677)
2016
3
Interstitial granulomatous dermatitis demonstrating small, discrete skin-colored papules. (27373135)
2016
4
Palisaded neutrophilic and granulomatous dermatitis - cutaneous manifestation of Lyme disease or connected with CTD? Case report. (27294654)
2016
5
Subcutaneous Dirofilariasis: A Masquerade of a Palisaded Granulomatous Dermatitis. (28000235)
2016
6
Generalized granulomatous dermatitis following Mycobacterium w (Mw) immunotherapy in lepromatous leprosy. (27891733)
2016
7
Interstitial granulomatous dermatitis occurring in a patient with SAPHO syndrome one month after starting leflunomide, and subsequently disappearing with ustekinumab. (27456988)
2016
8
Interstitial Granulomatous Dermatitis Associated with Rheumatoid Arthritis. (27274645)
2016
9
Infectious Granulomatous Dermatitis at a Tertiary Care Centre in North Maharashtra: A Histopathological Study. (28050374)
2016
10
First reported association of chronic lymphocytic leukaemia and interstitial granulomatous dermatitis. (27194675)
2016
11
The rope sign: a case of interstitial granulomatous dermatitis with arthritis. (26924028)
2016
12
Complete remission of disseminated granulomatous dermatitis related to chronic eosinophilic leukemia following allogeneic stem cell transplantation. (27267816)
2016
13
Palisaded Neutrophilic Granulomatous Dermatitis in a Child with Juvenile Idiopathic Arthritis on Etanercept. (26860064)
2016
14
BRAF Inhibitor-Induced Antitumoral Granulomatous Dermatitis Eruption in Advanced Melanoma. (26381028)
2015
15
Granulocyte colony-stimulating factor-induced granulomatous dermatitis with enlarged histiocytes clinically manifesting as painful edematous nodules with high fever similar to Sweet's syndrome. (25572429)
2015
16
Herpes zoster granulomatous dermatitis: histopathologic findings in a case series. (25970643)
2015
17
Interstitial Granulomatous Dermatitis as the Initial Manifestation of Myeloma. (26039702)
2015
18
Chronic Interstitial Granulomatous Dermatitis in Coccidioidomycosis. (26574343)
2015
19
Granulomatous Dermatitis as a Cutaneous Manifestation of Hematologic Disorders: The First Case Associated With Polycythemia Vera and a New Case Associated With Myelodysplasia. (26703820)
2015
20
Interstitial Granulomatous Dermatitis: A Clinicopathological Study. (25830722)
2015
21
Interstitial granulomatous dermatitis associated with systemic lupus erythematosus: case report and review of the literature. (26385222)
2015
22
Interstitial granulomatous dermatitis due to borreliosis. (25851752)
2015
23
Anisakis spp. induced granulomatous dermatitis in a harbour porpoise Phocoena phocoena and a bottlenose dolphin Tursiops truncatus. (25590777)
2015
24
Interstitial granulomatous dermatitis: a characteristic histological pattern with variable clinical manifestations. (26755914)
2015
25
Reactive Granulomatous Dermatitis: A Review of Palisaded Neutrophilic and Granulomatous Dermatitis, Interstitial Granulomatous Dermatitis, Interstitial Granulomatous Drug Reaction, and a Proposed Reclassification. (26143420)
2015
26
Interstitial granulomatous dermatitis: rare cutaneous manifestation of rheumatoid arthritis. (26131871)
2015
27
Granulomatous dermatitis in a 29-year-old man from Bangladesh. (26882390)
2015
28
Interstitial granulomatous dermatitis with prominent neutrophil infiltration. (26566699)
2015
29
Exacerbation of interstitial granulomatous dermatitis with arthritis by anakinra in a patient with diffuse large B-cell lymphoma. (24480300)
2014
30
Crystal deodorant-induced axillary granulomatous dermatitis. (23621443)
2014
31
Disseminated noninterstitial granulomatous dermatitis as a cutaneous manifestation of the preleukemic state in a patient with myelodysplasia and ulcerative colitis--apropos a case and review of the literature. (24950421)
2014
32
Interstitial granulomatous dermatitis successfully treated with etanercept. (24624249)
2014
33
Interstitial granulomatous dermatitis associated with gabapentin. (25384220)
2014
34
Varicella-zoster virus vaccination-induced granulomatous dermatitis. (25219728)
2014
35
Post-varicella-zoster virus granulomatous dermatitis: a report of 2 cases. (24505586)
2014
36
Interstitial Granulomatous Dermatitis Associated with Myelodysplastic Syndrome - Complete Clearance Under Therapy with 5-azacytidine. (24573709)
2014
37
Interstitial granulomatous dermatitis with arthritis accompanied by anaplastic large cell lymphoma. (24533900)
2014
38
Generalized Granulomatous Dermatitis Accompanied by Myelodysplastic Syndrome. (23817627)
2013
39
Ustekinumab therapy for severe interstitial granulomatous dermatitis with arthritis. (23677104)
2013
40
Palisaded neutrophilic and granulomatous dermatitis in a rheumatoid arthritis patient after treatment with adalimumab. (24201093)
2013
41
Combination therapy with intralesional triamcinolone and oral dapsone for management of palisaded neutrophilic and granulomatous dermatitis. (23473287)
2013
42
Palisaded neutrophilic and granulomatous dermatitis associated with ankylosing spondylitis. (23974221)
2013
43
Perforating granulomatous dermatitis reaction to exogenous tattoo pigment: a case report and review of the literature. (21986232)
2013
44
Pseudogranulomatous Spitz nevus: a variant of Spitz nevus with heavy inflammatory infiltrate mimicking a granulomatous dermatitis. (22985334)
2013
45
A cutaneous interstitial granulomatous dermatitis-like eruption arising in myelodysplasia with leukemic progression. (23221468)
2013
46
A child with interstitial granulomatous dermatitis and juvenile idiopathic arthritis. (23735003)
2013
47
A palpable erythematous cord over the trunk in a patient with systemic lupus erythematosus. Interstitial granulomatous dermatitis (IGD). (23677093)
2013
48
Interstitial granulomatous dermatitis and arthritis revealing oesophageal carcinoma. (23777491)
2013
49
Interstitial granulomatous dermatitis with arthritis presenting with the rope sign. (23531209)
2013
50
Palisaded neutrophilic and granulomatous dermatitis in association with subcutaneous nodular and systemic sarcoidosis. (24476612)
2013

Variations for Granulomatous Dermatitis

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Expression for genes affiliated with Granulomatous Dermatitis

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Search GEO for disease gene expression data for Granulomatous Dermatitis.

Pathways for genes affiliated with Granulomatous Dermatitis

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Pathways related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.5NOD2, TNF
29.5NOD2, TNF
3
Show member pathways
9.3BRAF, TNF

GO Terms for genes affiliated with Granulomatous Dermatitis

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Biological processes related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1activation of MAPK activityGO:000018710.2NOD2, TNF
2cellular response to organic cyclic compoundGO:007140710.2NOD2, TNF
3JNK cascadeGO:000725410.2NOD2, TNF
4negative regulation of mitotic cell cycleGO:004593010.1FOXC1, TNF
5positive regulation of interleukin-6 productionGO:003275510.1NOD2, TNF
6positive regulation of interleukin-8 productionGO:003275710.1NOD2, TNF
7animal organ morphogenesisGO:000988710.0BRAF, TNF
8positive regulation of JNK cascadeGO:004633010.0NOD2, TNF
9positive regulation of NIK/NF-kappaB signalingGO:190122410.0NOD2, TNF
10blood vessel remodelingGO:00019749.8ACE, FOXC1
11kidney developmentGO:00018229.8ACE, FOXC1
12positive regulation of ERK1 and ERK2 cascadeGO:00703749.5BRAF, NOD2, TNF
13positive regulation of gene expressionGO:00106289.4BRAF, FOXC1, TNF
14positive regulation of peptidyl-serine phosphorylationGO:00331389.3BRAF, TNF

Molecular functions related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1mitogen-activated protein kinase kinase bindingGO:00314349.0ACE, BRAF

Sources for Granulomatous Dermatitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet