MCID: GRN003
MIFTS: 31

Granulomatous Dermatitis malady

Categories: Skin diseases

Aliases & Classifications for Granulomatous Dermatitis

Aliases & Descriptions for Granulomatous Dermatitis:

Name: Granulomatous Dermatitis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:4397
NCIt 47 C3505
UMLS 69 C0743086

Summaries for Granulomatous Dermatitis

MalaCards based summary : Granulomatous Dermatitis is related to interstitial granulomatous dermatitis with arthritis and dermatitis. An important gene associated with Granulomatous Dermatitis is NOD2 (Nucleotide Binding Oligomerization Domain Containing 2), and among its related pathways/superpathways are TNF signaling pathway and Downstream signaling in naive CD8+ T cells. Affiliated tissues include neutrophil, skin and t cells, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and growth/size/body region

Related Diseases for Granulomatous Dermatitis

Diseases related to Granulomatous Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 106)
id Related Disease Score Top Affiliating Genes
1 interstitial granulomatous dermatitis with arthritis 12.1
2 dermatitis 10.7
3 arthritis 10.3
4 amyotrophic lateral sclerosis type 5 10.1 NOD2 TNF
5 psoriatic arthritis 10.1 NOD2 TNF
6 female reproductive system disease 10.1 NOD2 TNF
7 amyotrophic lateral sclerosis type 14 10.1 NOD2 TNF
8 parkinson disease 11 10.1 NOD2 TNF
9 meier-gorlin syndrome 3 10.1 NOD2 TNF
10 leptospirosis 10.1 NOD2 TNF
11 malignant histiocytosis 10.1 NOD2 TNF
12 histiocytoma 10.1 NOD2 TNF
13 functional gastric disease 10.1 NOD2 TNF
14 acute myeloid leukemia with recurrent genetic anomaly 10.1 NOD2 TNF
15 crohn's colitis 10.1 NOD2 TNF
16 central bilateral macrogyria 10.1 FOXC1 TNF
17 celiac disease 10.1 NOD2 TNF
18 benign eccrine breast spiradenoma 10.1 NOD2 TNF
19 endobronchial leiomyoma 10.1 NOD2 TNF
20 uterine ligament clear cell adenocarcinoma 10.1 NOD2 TNF
21 esophageal candidiasis 10.0 NOD2 TNF
22 rheumatoid arthritis 10.0
23 lupus erythematosus 10.0
24 systemic lupus erythematosus 10.0
25 severe hemophilia a 10.0 ACE TNF
26 cardiac sarcoidosis 10.0 ACE TNF
27 preaxial polydactyly of fingers 10.0 ACE TNF
28 juvenile amyotrophic lateral sclerosis with dementia 10.0 ACE TNF
29 joint disorders 10.0 ACE TNF
30 atrial septal defect 6 10.0 NOD2 TNF
31 tuberculosis 10.0 ACE TNF
32 peripheral artery disease 10.0 ACE TNF
33 alcoholic hepatitis 10.0 ACE TNF
34 oppositional defiant disorder 10.0 ACE TNF
35 choroiditis 10.0 ACE TNF
36 skin conditions 10.0 ACE TNF
37 retinal ischemia 10.0 ACE TNF
38 pyelonephritis 10.0 ACE TNF
39 limb ischemia 9.9 ACE TNF
40 familial nephrotic syndrome 9.9 ACE TNF
41 diabetic encephalopathy 9.9 ACE TNF
42 microscopic breast papilloma 9.9 ACE TNF
43 biliary cirrhosis, primary, 2 9.9 ACE TNF
44 acute chest syndrome 9.9 ACE TNF
45 anogenital venereal wart 9.9 ACE TNF
46 calcinosis 9.8 ACE TNF
47 newcastle disease 9.8 ACE NOD2 TNF
48 deafness, autosomal recessive 67 9.8 ACE NOD2 TNF
49 myelodysplastic syndrome 9.8
50 cutaneous leishmaniasis 9.8

Graphical network of the top 20 diseases related to Granulomatous Dermatitis:



Diseases related to Granulomatous Dermatitis

Symptoms & Phenotypes for Granulomatous Dermatitis

GenomeRNAi Phenotypes related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.17 ACE NOD2 TNF
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.17 ACE BRAF NOD2 TNF

MGI Mouse Phenotypes related to Granulomatous Dermatitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.65 ACE BRAF FOXC1 NOD2 TNF
2 digestive/alimentary MP:0005381 9.62 BRAF FOXC1 NOD2 TNF
3 homeostasis/metabolism MP:0005376 9.55 ACE BRAF FOXC1 NOD2 TNF
4 liver/biliary system MP:0005370 9.26 ACE BRAF FOXC1 TNF
5 reproductive system MP:0005389 8.92 TNF ACE BRAF FOXC1

Drugs & Therapeutics for Granulomatous Dermatitis

Search Clinical Trials , NIH Clinical Center for Granulomatous Dermatitis

Genetic Tests for Granulomatous Dermatitis

Anatomical Context for Granulomatous Dermatitis

MalaCards organs/tissues related to Granulomatous Dermatitis:

39
Neutrophil, Skin, T Cells, B Cells, Thyroid

Publications for Granulomatous Dermatitis

Articles related to Granulomatous Dermatitis:

(show top 50) (show all 168)
id Title Authors Year
1
Postherpetic Granulomatous Dermatitis in a Man Treated With Nivolumab. ( 28532783 )
2017
2
Papulonodular mucinosis with interstitial granulomatous dermatitis-like histological changes in a male patient with systemic lupus erythematosus. ( 27421677 )
2016
3
Interstitial granulomatous dermatitis demonstrating small, discrete skin-colored papules. ( 27373135 )
2016
4
Palisaded neutrophilic and granulomatous dermatitis - cutaneous manifestation of Lyme disease or connected with CTD? Case report. ( 27294654 )
2016
5
Subcutaneous Dirofilariasis: A Masquerade of a Palisaded Granulomatous Dermatitis. ( 28000235 )
2016
6
Generalized granulomatous dermatitis following Mycobacterium w (Mw) immunotherapy in lepromatous leprosy. ( 27891733 )
2016
7
Interstitial granulomatous dermatitis occurring in a patient with SAPHO syndrome one month after starting leflunomide, and subsequently disappearing with ustekinumab. ( 27456988 )
2016
8
Interstitial Granulomatous Dermatitis Associated with Rheumatoid Arthritis. ( 27274645 )
2016
9
Infectious Granulomatous Dermatitis at a Tertiary Care Centre in North Maharashtra: A Histopathological Study. ( 28050374 )
2016
10
First reported association of chronic lymphocytic leukaemia and interstitial granulomatous dermatitis. ( 27194675 )
2016
11
The rope sign: a case of interstitial granulomatous dermatitis with arthritis. ( 26924028 )
2016
12
Complete remission of disseminated granulomatous dermatitis related to chronic eosinophilic leukemia following allogeneic stem cell transplantation. ( 27267816 )
2016
13
Palisaded Neutrophilic Granulomatous Dermatitis in a Child with Juvenile Idiopathic Arthritis on Etanercept. ( 26860064 )
2016
14
BRAF Inhibitor-Induced Antitumoral Granulomatous Dermatitis Eruption in Advanced Melanoma. ( 26381028 )
2015
15
Granulocyte colony-stimulating factor-induced granulomatous dermatitis with enlarged histiocytes clinically manifesting as painful edematous nodules with high fever similar to Sweet's syndrome. ( 25572429 )
2015
16
Herpes zoster granulomatous dermatitis: histopathologic findings in a case series. ( 25970643 )
2015
17
Interstitial Granulomatous Dermatitis as the Initial Manifestation of Myeloma. ( 26039702 )
2015
18
Chronic Interstitial Granulomatous Dermatitis in Coccidioidomycosis. ( 26574343 )
2015
19
Granulomatous Dermatitis as a Cutaneous Manifestation of Hematologic Disorders: The First Case Associated With Polycythemia Vera and a New Case Associated With Myelodysplasia. ( 26703820 )
2015
20
Interstitial Granulomatous Dermatitis: A Clinicopathological Study. ( 25830722 )
2015
21
Interstitial granulomatous dermatitis associated with systemic lupus erythematosus: case report and review of the literature. ( 26385222 )
2015
22
Interstitial granulomatous dermatitis due to borreliosis. ( 25851752 )
2015
23
Anisakis spp. induced granulomatous dermatitis in a harbour porpoise Phocoena phocoena and a bottlenose dolphin Tursiops truncatus. ( 25590777 )
2015
24
Interstitial granulomatous dermatitis: a characteristic histological pattern with variable clinical manifestations. ( 26755914 )
2015
25
Reactive Granulomatous Dermatitis: A Review of Palisaded Neutrophilic and Granulomatous Dermatitis, Interstitial Granulomatous Dermatitis, Interstitial Granulomatous Drug Reaction, and a Proposed Reclassification. ( 26143420 )
2015
26
Interstitial granulomatous dermatitis: rare cutaneous manifestation of rheumatoid arthritis. ( 26131871 )
2015
27
Granulomatous dermatitis in a 29-year-old man from Bangladesh. ( 26882390 )
2015
28
Interstitial granulomatous dermatitis with prominent neutrophil infiltration. ( 26566699 )
2015
29
Exacerbation of interstitial granulomatous dermatitis with arthritis by anakinra in a patient with diffuse large B-cell lymphoma. ( 24480300 )
2014
30
Crystal deodorant-induced axillary granulomatous dermatitis. ( 23621443 )
2014
31
Disseminated noninterstitial granulomatous dermatitis as a cutaneous manifestation of the preleukemic state in a patient with myelodysplasia and ulcerative colitis--apropos a case and review of the literature. ( 24950421 )
2014
32
Interstitial granulomatous dermatitis successfully treated with etanercept. ( 24624249 )
2014
33
Interstitial granulomatous dermatitis associated with gabapentin. ( 25384220 )
2014
34
Varicella-zoster virus vaccination-induced granulomatous dermatitis. ( 25219728 )
2014
35
Post-varicella-zoster virus granulomatous dermatitis: a report of 2 cases. ( 24505586 )
2014
36
Interstitial Granulomatous Dermatitis Associated with Myelodysplastic Syndrome - Complete Clearance Under Therapy with 5-azacytidine. ( 24573709 )
2014
37
Interstitial granulomatous dermatitis with arthritis accompanied by anaplastic large cell lymphoma. ( 24533900 )
2014
38
Generalized Granulomatous Dermatitis Accompanied by Myelodysplastic Syndrome. ( 23817627 )
2013
39
Ustekinumab therapy for severe interstitial granulomatous dermatitis with arthritis. ( 23677104 )
2013
40
Palisaded neutrophilic and granulomatous dermatitis in a rheumatoid arthritis patient after treatment with adalimumab. ( 24201093 )
2013
41
Combination therapy with intralesional triamcinolone and oral dapsone for management of palisaded neutrophilic and granulomatous dermatitis. ( 23473287 )
2013
42
Palisaded neutrophilic and granulomatous dermatitis associated with ankylosing spondylitis. ( 23974221 )
2013
43
Perforating granulomatous dermatitis reaction to exogenous tattoo pigment: a case report and review of the literature. ( 21986232 )
2013
44
Pseudogranulomatous Spitz nevus: a variant of Spitz nevus with heavy inflammatory infiltrate mimicking a granulomatous dermatitis. ( 22985334 )
2013
45
A cutaneous interstitial granulomatous dermatitis-like eruption arising in myelodysplasia with leukemic progression. ( 23221468 )
2013
46
A child with interstitial granulomatous dermatitis and juvenile idiopathic arthritis. ( 23735003 )
2013
47
A palpable erythematous cord over the trunk in a patient with systemic lupus erythematosus. Interstitial granulomatous dermatitis (IGD). ( 23677093 )
2013
48
Interstitial granulomatous dermatitis and arthritis revealing oesophageal carcinoma. ( 23777491 )
2013
49
Interstitial granulomatous dermatitis with arthritis presenting with the rope sign. ( 23531209 )
2013
50
Palisaded neutrophilic and granulomatous dermatitis in association with subcutaneous nodular and systemic sarcoidosis. ( 24476612 )
2013

Variations for Granulomatous Dermatitis

Expression for Granulomatous Dermatitis

Search GEO for disease gene expression data for Granulomatous Dermatitis.

Pathways for Granulomatous Dermatitis

Pathways related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.19 NOD2 TNF
2
Show member pathways
10.74 BRAF TNF
3 9.98 NOD2 TNF

GO Terms for Granulomatous Dermatitis

Biological processes related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 9.54 BRAF TNF
2 positive regulation of gene expression GO:0010628 9.54 BRAF FOXC1 TNF
3 activation of MAPK activity GO:0000187 9.52 NOD2 TNF
4 kidney development GO:0001822 9.51 ACE FOXC1
5 cellular response to organic cyclic compound GO:0071407 9.49 NOD2 TNF
6 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.48 BRAF TNF
7 positive regulation of JNK cascade GO:0046330 9.46 NOD2 TNF
8 JNK cascade GO:0007254 9.43 NOD2 TNF
9 positive regulation of interleukin-6 production GO:0032755 9.4 NOD2 TNF
10 blood vessel remodeling GO:0001974 9.32 ACE FOXC1
11 negative regulation of mitotic cell cycle GO:0045930 9.26 FOXC1 TNF
12 positive regulation of interleukin-8 production GO:0032757 9.16 NOD2 TNF
13 positive regulation of NIK/NF-kappaB signaling GO:1901224 8.96 NOD2 TNF
14 positive regulation of ERK1 and ERK2 cascade GO:0070374 8.8 BRAF NOD2 TNF

Molecular functions related to Granulomatous Dermatitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 mitogen-activated protein kinase kinase binding GO:0031434 8.62 ACE BRAF

Sources for Granulomatous Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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