MCID: GRN032
MIFTS: 19

Granulomatous Slack Skin Disease malady

Categories: Rare diseases, Skin diseases, Blood diseases

Aliases & Classifications for Granulomatous Slack Skin Disease

Aliases & Descriptions for Granulomatous Slack Skin Disease:

Name: Granulomatous Slack Skin Disease 50 69
Granulomatous Slack Skin 50 56 52 69

Characteristics:

Orphanet epidemiological data:

56
granulomatous slack skin
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: Adult; Age of death: normal life expectancy;

Classifications:



External Ids:

Orphanet 56 ORPHA33111
UMLS via Orphanet 70 C0376407 C0457002
ICD10 via Orphanet 34 C84.0

Summaries for Granulomatous Slack Skin Disease

NIH Rare Diseases : 50 granulomatous slack skin disease (gss) is a very rare cutaneous disorder and less than 50 cases have been reported so far. the cause of this condition is unknown but it is often associated with mycosis fungiodes and other lymphoproliferative disorders such as hodgkin and non-hodgkin lymphoma. signs and symptoms include loose hanging skin and fine wrinkling of the skin or papules. these symptoms are most often located in the axilla, groin and stomach. there is no specific treatment regimen for gss. treatment options are based on the recommendations for cutaneous t-cell lymphoma and include topical steroids, surgical remvoval of skin folds, radiation therapy and chemotherapy. last updated: 1/24/2013

MalaCards based summary : Granulomatous Slack Skin Disease, also known as granulomatous slack skin, is related to skin disease and mycosis fungoides, and has symptoms including nephrocalcinosis, hypercalcemia and erythema. An important gene associated with Granulomatous Slack Skin Disease is TRB (T-Cell Receptor Beta Locus). Affiliated tissues include skin, t cells and kidney.

Wikipedia : 71 Granulomatous slack skin (GSS) is a rare cutaneous condition, a variant of lymphoma that typically... more...

Related Diseases for Granulomatous Slack Skin Disease

Diseases related to Granulomatous Slack Skin Disease via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 skin disease 10.3
2 mycosis fungoides 9.9

Symptoms & Phenotypes for Granulomatous Slack Skin Disease

Human phenotypes related to Granulomatous Slack Skin Disease:

56 32 (show all 10)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 nephrocalcinosis 56 32 Occasional (29-5%) HP:0000121
2 hypercalcemia 56 32 Occasional (29-5%) HP:0003072
3 erythema 56 32 Frequent (79-30%) HP:0010783
4 redundant skin 56 32 Frequent (79-30%) HP:0001582
5 acute kidney injury 56 32 Occasional (29-5%) HP:0001919
6 abnormality of the lymph nodes 56 32 Occasional (29-5%) HP:0002733
7 stiff skin 56 32 Frequent (79-30%) HP:0030053
8 hodgkin lymphoma 56 32 Frequent (79-30%) HP:0012189
9 lymphoma 56 Frequent (79-30%)
10 cutis laxa 56 Frequent (79-30%)

Drugs & Therapeutics for Granulomatous Slack Skin Disease

Search Clinical Trials , NIH Clinical Center for Granulomatous Slack Skin Disease

Genetic Tests for Granulomatous Slack Skin Disease

Anatomical Context for Granulomatous Slack Skin Disease

MalaCards organs/tissues related to Granulomatous Slack Skin Disease:

39
Skin, T Cells, Kidney, Lymph Node

Publications for Granulomatous Slack Skin Disease

Articles related to Granulomatous Slack Skin Disease:

id Title Authors Year
1
Granulomatous slack skin disease: a review, in comparison with mycosis fungoides. ( 22435618 )
2012
2
An unusual case of granulomatous slack skin disease with necrobiosis. ( 18806490 )
2008
3
Granulomatous slack skin disease in a child: the outcome. ( 18035987 )
2007
4
Granulomatous slack skin disease--disease features and response to pentostatin. ( 14531912 )
2003
5
A case of primary cutaneous CD30+ T-cell lymphoproliferative disorder with features of granulomatous slack skin disease. ( 12410714 )
2002

Variations for Granulomatous Slack Skin Disease

Expression for Granulomatous Slack Skin Disease

Search GEO for disease gene expression data for Granulomatous Slack Skin Disease.

Pathways for Granulomatous Slack Skin Disease

GO Terms for Granulomatous Slack Skin Disease

Sources for Granulomatous Slack Skin Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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