GTCT
MCID: GRN022
MIFTS: 43

Granulosa Cell Tumor of the Ovary (GTCT) malady

Rare diseases, Gastrointestinal diseases, Cancer diseases categories
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Summaries for Granulosa Cell Tumor of the Ovary

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43NIH Rare Diseases, 33MalaCards
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NIH Rare Diseases:43 Granulosa cell tumor of the ovary is a rare type of ovarian cancer that accounts for approximately 2% of all ovarian tumors. this type of tumor is known as a sex cord-stromal tumor and usually occurs in adults. granulosa cell tumors of the ovary cause higher than normal levels of estrogen in a woman's body.  the symptoms of this excess estrogen depend on the woman's menstrual status; the most common symptoms include early puberty for affected young girls, an increase in abdomen size or irregularities of menstrual cycles in premenopausal women, and abnormal uterine bleeding in postmenopausal women. the exact cause of granulosa cell tumors is unknown.  treatment consists of surgery to remove the tumor, and additional treatments may also be used depending on the extent of the tumor. last updated: 11/14/2011

MalaCards: Granulosa Cell Tumor of the Ovary, also known as granulosa theca cell tumor of the ovary, is related to amenorrhea and sertoli cell tumor. An important gene associated with Granulosa Cell Tumor of the Ovary is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Cardiac Progenitor Differentiation and Selected targets of CREB1. The compounds 111in-pentetreotide and estracyt have been mentioned in the context of this disorder. Affiliated tissues include ovary, breast and bone.

Aliases & Classifications for Granulosa Cell Tumor of the Ovary

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43NIH Rare Diseases, 62UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

granulosa cell tumor of the ovary 43 62
granulosa theca cell tumor of the ovary 43
adult granulosa cell tumor of the ovary 43
gastrointestinal carcinoid tumor 62
granulosa theca cell tumor 43
gct of the ovary 43
gtct 43


Related Diseases for Granulosa Cell Tumor of the Ovary

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17GeneCards, 18GeneDecks
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Diseases related to Granulosa Cell Tumor of the Ovary via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1amenorrhea30.8INS, PRL
2sertoli cell tumor30.6SYP, ENO2
3endometrial carcinoma30.6CHGA, CEACAM3, KRT7
4breast cancer30.3INS, SERPINA1, CP, PRL, CEACAM3, KRT7
5hepatitis10.7
6peritonitis10.6
7fibroma10.5
8hypercalcemia10.5
9sertoli-leydig cell tumor10.4
10premature menopause10.4
11tuberous sclerosis10.4
12hyperprolactinemia10.4
13pancytopenia10.4
14hemangiopericytoma10.4
15leiomyoma10.4
16leydig cell tumor10.4
17aromatase deficiency10.4
18gynandroblastoma10.4
19ovarian fibroma10.4
20monosomy 2210.4
21luteoma10.4
22somatostatinoma10.1CHGA
23melanotic neuroectodermal tumor10.1SYP
24dysembryoplastic neuroepithelial tumor10.1SYP
25hemosiderosis10.1CP
26siderosis10.1CP
27central neurocytoma10.1CHGA, SYP
28cerebral primitive neuroectodermal tumor10.1ENO2
29rhabdoid tumor10.1ACTC1, SYP
30pancreatic islet cell tumors10.1SYP, CHGA
31endocrine gland cancer10.1CHGA, SYP
32glomus tumor10.1ACTC1, SYP
33neurofibroma10.1ACTC1, SYP
34empty sella syndrome10.1PRL
35spindle cell sarcoma10.1ACTC1, KRT7
36pituitary apoplexy10.1PRL
37adult respiratory distress syndrome10.1SERPINA1, CP
38pituitary carcinoma10.1PRL
39signet ring cell adenocarcinoma10.1CHGA, KRT7
40hyperinsulinemic hypoglycemia10.1INS, CHGA
41malignant fibroxanthoma10.1SERPINA1, ACTC1
42giant cell tumor10.1CEACAM3, ACTC1
43pancreatic ductal carcinoma10.1CHGA, KRT7
44granular cell tumor10.1SYP, ENO2
45adrenocortical carcinoma10.1CHGA, SYP
46abrikosov's tumor10.1ACTC1, KRT7
47olfactory neuroblastoma10.1SYP, ENO2
48adrenal adenoma10.1SYP, CHGA
49neuroepithelioma10.1SYP, ENO2
50ganglioneuroblastoma10.1SYP, ENO2

Graphical network of the top 20 diseases related to Granulosa Cell Tumor of the Ovary:



Diseases related to granulosa cell tumor of the ovary

Symptoms for Granulosa Cell Tumor of the Ovary

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Drugs & Therapeutics for Granulosa Cell Tumor of the Ovary

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

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Genetic Tests for Granulosa Cell Tumor of the Ovary

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Anatomical Context for Granulosa Cell Tumor of the Ovary

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33MalaCards
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MalaCards organs/tissues related to Granulosa Cell Tumor of the Ovary:

33
Ovary, Breast, Bone, Lung, Adrenal gland

Animal Models for Granulosa Cell Tumor of the Ovary or affiliated genes

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Publications for Granulosa Cell Tumor of the Ovary

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52PubMed
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Articles related to Granulosa Cell Tumor of the Ovary:

(show top 50)    (show all 133)
idTitleAuthorsYear
1
Granulosa cell tumor of the ovary with high FDG uptake. (23640219)
2013
2
Successful treatment of adult-type granulosa cell tumor of the ovary by palliative radiotherapy. (22175649)
2012
3
Primary amenorrhea due to juvenile granulosa-cell tumor of the ovary: a case report. (22353374)
2012
4
Delayed menopause due to granulosa cell tumor of the ovary. (22408338)
2011
5
Prolonged survival following maximal cytoreductive effort for peritoneal metastases from recurrent granulosa cell tumor of the ovary. (21998767)
2011
6
Granulosa cell tumor of the ovary: time to launch a new prospective trial. (21998755)
2011
7
Medico-legal observations concerning a mortal case of granulosa cell tumor of the ovary in an 8-month-old infant. (21843743)
2011
8
Synchronous adult-type granulosa cell tumor of the ovary with ovarian fibroma: a case report. (22335040)
2011
9
FOXL2 mutation and large-scale genomic imbalances in adult granulosa cell tumors of the ovary. (22200085)
2011
10
Granulosa cell tumor of the ovary: cytologic findings. (20715655)
2010
11
Mutation of FOXL2 in granulosa-cell tumors of the ovary. (19516027)
2009
12
Prognostic factors in adult granulosa cell tumor of the ovary. (19198715)
2009
13
Juvenile granulosa cell tumor of the ovary presenting with pleural effusion and ascites. (19225930)
2009
14
Cystic fluid and fine needle aspiration cytopathology of cystic adult granulosa cell tumor of the ovary: a case report. (18500005)
2008
15
Glucose metabolism and angiogenesis in granulosa cell tumors of the ovary: activation of Akt, expression of M2PK, TKTL1 and VEGF. (18394773)
2008
16
Juvenile granulosa cell tumor of the ovary associated with hypercalcemia. (17849133)
2008
17
Androgenic juvenile granulosa cell tumor of the ovary with cystic presentation: a case report. (17624097)
2007
18
Juvenile granulosa cell tumor of the ovary associated with tuberous sclerosis. (16516278)
2006
19
Clinicopathological prognostic factors of adult granulosa cell tumor of the ovary--a study of 37 cases. (16366090)
2005
20
Monosomy 22 as a diagnostic aid in a case of late recurrence of adult granulosa cell tumor of the ovary. (15588863)
2005
21
Multifocal intrafollicular granulosa cell tumor of the ovary associated with an unusual germline p53 mutation. (15073606)
2004
22
Granulosa cell tumor of the ovary metastasizing to adrenal gland 13 years after initial diagnosis--diagnostic difficulties and immunohistochemical study]. (15058173)
2003
23
Granulosa cell tumor of the ovary: common findings and unusual appearances on CT and MR. (12439311)
2002
24
Juvenile granulosa cell tumor of the ovary: imprint cytology findings. (12462106)
2002
25
Hyperprolactinemia complicating juvenile granulosa cell tumor of the ovary. (11531301)
2001
26
Bone metastasis from a granulosa cell tumor of the ovary. (11606104)
2001
27
Case 5: gynecological. Granulosa cell tumor of the ovary with endometrial carcinoma. (10811416)
2000
28
Severe hypercalcemia in association with a juvenile granulosa cell tumor of the ovary. (10742079)
2000
29
Masculinizing granulosa cell tumor of the ovary in a postmenopausal woman. A case report. (10509308)
1999
30
Radiation treatment of advanced or recurrent granulosa cell tumor of the ovary. (10094877)
1999
31
Granulosa cell tumor of the ovary. (9880981)
1998
32
Prognostic factors in adult granulosa cell tumor of the ovary. (9149022)
1997
33
Management of advanced juvenile granulosa cell tumor of the ovary. (9038278)
1997
34
Juvenile granulosa cell tumor of the ovary in infants: a clinicopathologic study of three cases and review of the literature. (9165474)
1997
35
The management of granulosa cell tumor of the ovary--a case history. (8839909)
1996
36
Recurrent granulosa cell tumor of the ovary 37 years after initial diagnosis: a case report and review of the literature. (8774662)
1996
37
Juvenile granulosa-cell tumor of the ovary - interphase cytogenetics for chromosome-12 and chromosome-x and flow cytometric DNA-ploidy study. (21552888)
1995
38
Luteinized adult granulosa cell tumors of the ovary: a report of four cases. (7814191)
1994
39
Granulosa cell tumor of the ovary with diffuse true hepatic differentiation simulating stromal luteinization. (7680545)
1993
40
Congenital bilateral juvenile granulosa cell tumor of the ovary in leprechaunism: a case report. (8247952)
1993
41
Granulosa cell tumor of the ovary. (2178047)
1990
42
Prognostic value of flow cytometric DNA content analysis in granulosa cell tumor of the ovary. (2302667)
1990
43
Juvenile granulosa cell tumor of the ovary in children: a clinical study of 15 cases. (3373268)
1988
44
Cystic juvenile granulosa cell tumor of the ovary. (3176932)
1988
45
A clinicopathologic study of 92 cases of granulosa cell tumor of the ovary with special reference to the factors influencing prognosis. (1109770)
1975
46
Granulosa-cell tumor of the ovary. Report of case. (13766011)
1961
47
Granulosa cell tumor of the ovary. (20250086)
1947
48
Granulosa-cell tumor of the ovary. (21001409)
1946
49
Granulosa cell tumor of the ovary; a clinical and pathologic review of 62 cases. (21005311)
1945
50
GRANULOSA CELL TUMOR OF THE OVARY: REPORT OF A CASE. (17857589)
1940

Variations for Granulosa Cell Tumor of the Ovary

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Expression for genes affiliated with Granulosa Cell Tumor of the Ovary

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Granulosa Cell Tumor of the Ovary

Search GEO for disease gene expression data for Granulosa Cell Tumor of the Ovary.

Pathways for genes affiliated with Granulosa Cell Tumor of the Ovary

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50PathCards, 38NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Granulosa Cell Tumor of the Ovary according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ACTC1, INS
29.6CHGA, INS
3
Show member pathways
FOXA transcription factor networks38
9.5SERPINA1, INS
49.5SERPINA1, INS
59.5INS, PRL

Compounds for genes affiliated with Granulosa Cell Tumor of the Ovary

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45Novoseek, 24HMDB, 61Tocris Bioscience, 11DrugBank, 29IUPHAR, 51PharmGKB
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Compounds related to Granulosa Cell Tumor of the Ovary according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1111in-pentetreotide459.8SYP, CHGA
2estracyt459.8ENO2, CHGA
3smcc459.7ENO2, CHGA, SYP
4metanephrine45 2410.6CHGA, ENO2
5l-amino acid459.6SYP, ENO2, CHGA
6homovanillic acid45 2410.5CHGA, ENO2, PRL
7streptozotocin459.5INS, SYP, CHGA
8flutamide45 61 1111.5CHGA, PRL, ENO2
9s 100459.4SYP, ACTC1, CHGA, ENO2
10reticulin459.4SYP, KRT7, ACTC1
11silver459.4ENO2, SYP, CHGA
125-hydroxyindoleacetic acid45 2410.3CEACAM3, CHGA, ENO2
13methanol45 2410.3KRT7, ACTC1, CHGA
14levodopa45 1110.2PRL, CHGA, CP
155-hydroxytryptamine459.2PRL, CHGA, SYP, ENO2
16uric acid45 2410.1INS, CP, ENO2
17ribonucleic acid459.1CHGA, ENO2, PRL, ACTC1
18epinephrine45 24 1111.0CP, CHGA, INS, PRL
19octreotide45 61 29 1112.0CHGA, PRL, INS, ENO2
20amine459.0ENO2, SYP, CHGA
21mucicarmine458.8ACTC1, SYP, KRT7, CEACAM3
22thyroxine45 249.8CP, PRL, CEACAM3, INS
23dopamine45 29 24 1111.8PRL, CHGA, CP, SYP, ENO2
24steroid458.7CEACAM3, ACTC1, CHGA, SYP, PRL
25norepinephrine45 24 1110.7PRL, SYP, CHGA, INS, ENO2
26fibrinogen458.6CHGA, INS, CEACAM3, CP, SERPINA1
27formaldehyde45 249.6ENO2, KRT7, SYP, ACTC1, CHGA
28glutamate458.6SYP, INS, CP, ENO2, CHGA
29b 723458.5CEACAM3, ACTC1, SYP, KRT7, CHGA
30sialic acid458.5ENO2, KRT7, CP, CEACAM3
31nitric oxide45 24 1110.5ENO2, CEACAM3, CHGA, SERPINA1, SYP
32lactate458.4ENO2, CEACAM3, CHGA, INS, CP
33iron45 249.4SERPINA1, CP, ACTC1, KRT7, ENO2
34oxygen45 249.3CEACAM3, CP, ACTC1, ENO2, SERPINA1, CHGA
35arginine458.2CP, CHGA, PRL, KRT7, INS
36retinoic acid45 249.1CP, CHGA, ENO2, KRT7, SYP, ACTC1
37glycogen45 249.1INS, ACTC1, CHGA, KRT7, ENO2, SYP
38dexamethasone45 51 29 1111.1ACTC1, CHGA, PRL, SYP, CP, INS
39hematoxylin458.0KRT7, ENO2, SYP, CHGA, CEACAM3, ACTC1
40cholesterol45 29 24 1110.8INS, SERPINA1, CP, ENO2, SYP, CEACAM3
41acth457.7SYP, CEACAM3, PRL, CHGA, ENO2, SERPINA1
42vegf457.6ENO2, KRT7, SYP, ACTC1, CP, CHGA
43paraffin457.6ACTC1, CEACAM3, KRT7, ENO2, CHGA, SERPINA1
44lipid457.6SYP, KRT7, CP, ENO2, SERPINA1, INS
45creatinine457.5SYP, CHGA, CEACAM3, ACTC1, INS, ENO2
46testosterone45 61 24 1110.2SYP, CHGA, CP, INS, KRT7, ENO2
47progesterone45 29 61 24 1111.1ENO2, ACTC1, SYP, SERPINA1, CEACAM3, PRL
48tyrosine457.0CHGA, ENO2, INS, SERPINA1, KRT7, SYP
49glucose456.9INS, KRT7, ACTC1, CEACAM3, PRL, ENO2
50estrogen456.2CP, CHGA, PRL, CEACAM3, ACTC1, SYP

GO Terms for genes affiliated with Granulosa Cell Tumor of the Ovary

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16Gene Ontology
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Cellular components related to Granulosa Cell Tumor of the Ovary according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.4SERPINA1, CP, CHGA, PRL, INS
2extracellular spaceGO:0056158.0ENO2, ACTC1, CP, SERPINA1, INS

Biological processes related to Granulosa Cell Tumor of the Ovary according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:0069539.5SERPINA1, INS

Products for genes affiliated with Granulosa Cell Tumor of the Ovary

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25ICD10
26ICD10 via Orphanet
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30KEGG
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