GTCT
MCID: GRN022
MIFTS: 42

Granulosa Cell Tumor of the Ovary (GTCT) malady

Rare diseases, Gastrointestinal diseases, Cancer diseases categories

Summaries for Granulosa Cell Tumor of the Ovary

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NIH Rare Diseases:42 Granulosa cell tumor of the ovary is a rare type of ovarian cancer that accounts for approximately 2% of all ovarian tumors. this type of tumor is known as a sex cord-stromal tumor and usually occurs in adults. granulosa cell tumors of the ovary cause higher than normal levels of estrogen in a woman's body.  the symptoms of this excess estrogen depend on the woman's menstrual status; the most common symptoms include early puberty for affected young girls, an increase in abdomen size or irregularities of menstrual cycles in premenopausal women, and abnormal uterine bleeding in postmenopausal women. the exact cause of granulosa cell tumors is unknown.  treatment consists of surgery to remove the tumor, and additional treatments may also be used depending on the extent of the tumor. last updated: 11/14/2011

MalaCards based summary: Granulosa Cell Tumor of the Ovary, also known as granulosa theca cell tumor of the ovary, is related to sertoli cell tumor and amenorrhea. An important gene associated with Granulosa Cell Tumor of the Ovary is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Cardiac Progenitor Differentiation and Selected targets of CREB1. The compounds 111in-pentetreotide and estracyt have been mentioned in the context of this disorder. Affiliated tissues include ovary, breast and bone.

Aliases & Classifications for Granulosa Cell Tumor of the Ovary

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Granulosa Cell Tumor of the Ovary, Aliases & Descriptions:

Name: Granulosa Cell Tumor of the Ovary 42 61
Granulosa Theca Cell Tumor of the Ovary 42 61
Adult Granulosa Cell Tumor of the Ovary 42 61
Gastrointestinal Carcinoid Tumor 61
 
Granulosa Theca Cell Tumor 42
Gct of the Ovary 42
Gtct 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Gastrointestinal diseases


Related Diseases for Granulosa Cell Tumor of the Ovary

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Diseases related to Granulosa Cell Tumor of the Ovary via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1sertoli cell tumor31.0SYP, ENO2
2amenorrhea30.9INS, PRL
3endometrial carcinoma30.7CHGA, CEACAM3, KRT7
4breast cancer29.6INS, SERPINA1, CP, PRL, CEACAM3, KRT7
5hepatitis10.7
6peritonitis10.6
7somatostatinoma10.5CHGA
8melanotic neuroectodermal tumor10.5SYP
9fibroma10.5
10hypercalcemia10.5
11dysembryoplastic neuroepithelial tumor10.5SYP
12hemosiderosis10.5CP
13siderosis10.5CP
14central neurocytoma10.4CHGA, SYP
15cerebral primitive neuroectodermal tumor10.4ENO2
16rhabdoid tumor10.4ACTC1, SYP
17pancreatic islet cell tumors10.4SYP, CHGA
18sertoli-leydig cell tumor10.4
19tuberous sclerosis10.4
20hyperprolactinemia10.4
21pancytopenia10.4
22premature menopause10.4
23hemangiopericytoma10.4
24leiomyoma10.4
25leydig cell tumor10.4
26aromatase deficiency10.4
27gynandroblastoma10.4
28ovarian fibroma10.4
29monosomy 2210.4
30endocrine gland cancer10.4CHGA, SYP
31paraganglioma10.4ACTC1, SYP
32luteoma10.4
33neurofibroma10.3ACTC1, SYP
34empty sella syndrome10.3PRL
35spindle cell sarcoma10.3ACTC1, KRT7
36pituitary apoplexy10.3PRL
37adult respiratory distress syndrome10.3SERPINA1, CP
38pituitary carcinoma10.3PRL
39signet ring cell adenocarcinoma10.3CHGA, KRT7
40hyperinsulinemic hypoglycemia10.3INS, CHGA
41malignant fibroxanthoma10.3SERPINA1, ACTC1
42giant cell tumor10.3CEACAM3, ACTC1
43pancreatic ductal carcinoma10.3CHGA, KRT7
44granular cell tumor10.3SYP, ENO2
45adrenocortical carcinoma10.3CHGA, SYP
46abrikosov's tumor10.3ACTC1, KRT7
47olfactory neuroblastoma10.3SYP, ENO2
48adrenal cortical adenoma10.3SYP, CHGA
49neuroectodermal tumor10.3SYP, ENO2
50ganglioneuroblastoma10.3SYP, ENO2

Graphical network of the top 20 diseases related to Granulosa Cell Tumor of the Ovary:



Diseases related to granulosa cell tumor of the ovary

Symptoms for Granulosa Cell Tumor of the Ovary

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Drugs & Therapeutics for Granulosa Cell Tumor of the Ovary

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Drug clinical trials:

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Genetic Tests for Granulosa Cell Tumor of the Ovary

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Anatomical Context for Granulosa Cell Tumor of the Ovary

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MalaCards organs/tissues related to Granulosa Cell Tumor of the Ovary:

32
Ovary, Breast, Bone, Lung, Adrenal gland

Animal Models for Granulosa Cell Tumor of the Ovary or affiliated genes

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Publications for Granulosa Cell Tumor of the Ovary

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Articles related to Granulosa Cell Tumor of the Ovary:

(show top 50)    (show all 138)
idTitleAuthorsYear
1
Parameters for predicting granulosa cell tumor of the ovary: a single center retrospective comparative study. (25339044)
2014
2
Granulosa cell tumor of the ovary with high FDG uptake. (23640219)
2013
3
Successful treatment of adult-type granulosa cell tumor of the ovary by palliative radiotherapy. (22175649)
2012
4
Primary amenorrhea due to juvenile granulosa-cell tumor of the ovary: a case report. (22353374)
2012
5
Delayed menopause due to granulosa cell tumor of the ovary. (22408338)
2011
6
Prolonged survival following maximal cytoreductive effort for peritoneal metastases from recurrent granulosa cell tumor of the ovary. (21998767)
2011
7
Granulosa cell tumor of the ovary: time to launch a new prospective trial. (21998755)
2011
8
Medico-legal observations concerning a mortal case of granulosa cell tumor of the ovary in an 8-month-old infant. (21843743)
2011
9
Synchronous adult-type granulosa cell tumor of the ovary with ovarian fibroma: a case report. (22335040)
2011
10
FOXL2 mutation and large-scale genomic imbalances in adult granulosa cell tumors of the ovary. (22200085)
2011
11
Granulosa cell tumor of the ovary: cytologic findings. (20715655)
2010
12
Mutation of FOXL2 in granulosa-cell tumors of the ovary. (19516027)
2009
13
Prognostic factors in adult granulosa cell tumor of the ovary. (19198715)
2009
14
Juvenile granulosa cell tumor of the ovary presenting with pleural effusion and ascites. (19225930)
2009
15
Cystic fluid and fine needle aspiration cytopathology of cystic adult granulosa cell tumor of the ovary: a case report. (18500005)
2008
16
Glucose metabolism and angiogenesis in granulosa cell tumors of the ovary: activation of Akt, expression of M2PK, TKTL1 and VEGF. (18394773)
2008
17
Juvenile granulosa cell tumor of the ovary associated with hypercalcemia. (17849133)
2008
18
Juvenile granulosa cell tumor of the ovary associated with tuberous sclerosis. (16516278)
2006
19
Clinicopathological prognostic factors of adult granulosa cell tumor of the ovary--a study of 37 cases. (16366090)
2005
20
Monosomy 22 as a diagnostic aid in a case of late recurrence of adult granulosa cell tumor of the ovary. (15588863)
2005
21
Multifocal intrafollicular granulosa cell tumor of the ovary associated with an unusual germline p53 mutation. (15073606)
2004
22
Granulosa cell tumor of the ovary metastasizing to adrenal gland 13 years after initial diagnosis--diagnostic difficulties and immunohistochemical study]. (15058173)
2003
23
Granulosa cell tumor of the ovary: common findings and unusual appearances on CT and MR. (12439311)
2002
24
Juvenile granulosa cell tumor of the ovary: imprint cytology findings. (12462106)
2002
25
Hyperprolactinemia complicating juvenile granulosa cell tumor of the ovary. (11531301)
2001
26
Bone metastasis from a granulosa cell tumor of the ovary. (11606104)
2001
27
Case 5: gynecological. Granulosa cell tumor of the ovary with endometrial carcinoma. (10811416)
2000
28
Severe hypercalcemia in association with a juvenile granulosa cell tumor of the ovary. (10742079)
2000
29
Masculinizing granulosa cell tumor of the ovary in a postmenopausal woman. A case report. (10509308)
1999
30
Radiation treatment of advanced or recurrent granulosa cell tumor of the ovary. (10094877)
1999
31
Granulosa cell tumor of the ovary. (9880981)
1998
32
Prognostic factors in adult granulosa cell tumor of the ovary. (9149022)
1997
33
Management of advanced juvenile granulosa cell tumor of the ovary. (9038278)
1997
34
Juvenile granulosa cell tumor of the ovary in infants: a clinicopathologic study of three cases and review of the literature. (9165474)
1997
35
The management of granulosa cell tumor of the ovary--a case history. (8839909)
1996
36
Recurrent granulosa cell tumor of the ovary 37 years after initial diagnosis: a case report and review of the literature. (8774662)
1996
37
Juvenile granulosa-cell tumor of the ovary - interphase cytogenetics for chromosome-12 and chromosome-x and flow cytometric DNA-ploidy study. (21552888)
1995
38
Luteinized adult granulosa cell tumors of the ovary: a report of four cases. (7814191)
1994
39
Granulosa cell tumor of the ovary with diffuse true hepatic differentiation simulating stromal luteinization. (7680545)
1993
40
Congenital bilateral juvenile granulosa cell tumor of the ovary in leprechaunism: a case report. (8247952)
1993
41
Granulosa cell tumor of the ovary. (2178047)
1990
42
Prognostic value of flow cytometric DNA content analysis in granulosa cell tumor of the ovary. (2302667)
1990
43
Juvenile granulosa cell tumor of the ovary in children: a clinical study of 15 cases. (3373268)
1988
44
Cystic juvenile granulosa cell tumor of the ovary. (3176932)
1988
45
A clinicopathologic study of 92 cases of granulosa cell tumor of the ovary with special reference to the factors influencing prognosis. (1109770)
1975
46
Granulosa-cell tumor of the ovary. Report of case. (13766011)
1961
47
Granulosa cell tumor of the ovary. (20250086)
1947
48
Granulosa-cell tumor of the ovary. (21001409)
1946
49
Granulosa cell tumor of the ovary; a clinical and pathologic review of 62 cases. (21005311)
1945
50
GRANULOSA CELL TUMOR OF THE OVARY: REPORT OF A CASE. (17857589)
1940

Variations for Granulosa Cell Tumor of the Ovary

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Expression for genes affiliated with Granulosa Cell Tumor of the Ovary

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Expression patterns in normal tissues for genes affiliated with Granulosa Cell Tumor of the Ovary

Search GEO for disease gene expression data for Granulosa Cell Tumor of the Ovary.

Pathways for genes affiliated with Granulosa Cell Tumor of the Ovary

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Pathways related to Granulosa Cell Tumor of the Ovary according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ACTC1, INS
29.6CHGA, INS
3
Show member pathways
FOXA transcription factor networks37
9.5SERPINA1, INS
49.5SERPINA1, INS
59.5INS, PRL

Compounds for genes affiliated with Granulosa Cell Tumor of the Ovary

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Compounds related to Granulosa Cell Tumor of the Ovary according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1111in-pentetreotide449.8SYP, CHGA
2estracyt449.8ENO2, CHGA
3smcc449.7CHGA, SYP, ENO2
4metanephrine44 2510.6ENO2, CHGA
5l-amino acid449.6ENO2, SYP, CHGA
6homovanillic acid44 2510.5ENO2, PRL, CHGA
7streptozotocin449.5SYP, CHGA, INS
8flutamide44 60 1211.5CHGA, PRL, ENO2
9s 100449.4CHGA, ACTC1, SYP, ENO2
10reticulin449.4ACTC1, SYP, KRT7
11silver449.4CHGA, SYP, ENO2
125-hydroxyindoleacetic acid44 2510.3CHGA, CEACAM3, ENO2
13methanol44 2510.3KRT7, ACTC1, CHGA
14levodopa44 1210.2CP, CHGA, PRL
155-hydroxytryptamine449.2CHGA, PRL, SYP, ENO2
16uric acid44 2510.1ENO2, CP, INS
17ribonucleic acid449.1CHGA, PRL, ACTC1, ENO2
18epinephrine44 25 1211.0PRL, CHGA, CP, INS
19octreotide44 60 29 1212.0INS, CHGA, PRL, ENO2
20amine449.0ENO2, SYP, CHGA
21mucicarmine448.8CEACAM3, ACTC1, SYP, KRT7
22thyroxine44 259.8INS, CP, PRL, CEACAM3
23dopamine44 29 25 1211.8ENO2, SYP, PRL, CHGA, CP
24steroid448.7CHGA, PRL, CEACAM3, ACTC1, SYP
25norepinephrine44 25 1210.7ENO2, SYP, PRL, CHGA, INS
26fibrinogen448.6INS, SERPINA1, CP, CHGA, CEACAM3
27formaldehyde44 259.6ENO2, KRT7, SYP, ACTC1, CHGA
28glutamate448.6INS, CP, CHGA, SYP, ENO2
29b 723448.5CHGA, CEACAM3, ACTC1, SYP, KRT7
30sialic acid448.5ENO2, KRT7, CEACAM3, CP
31nitric oxide44 25 1210.5ENO2, SYP, CEACAM3, CHGA, SERPINA1
32lactate448.4INS, CP, CHGA, CEACAM3, ENO2
33iron44 259.4SERPINA1, CP, ACTC1, KRT7, ENO2
34oxygen44 259.3SERPINA1, CP, CHGA, CEACAM3, ACTC1, ENO2
35arginine448.2INS, CP, CHGA, PRL, KRT7
36retinoic acid44 259.1CP, CHGA, ACTC1, SYP, KRT7, ENO2
37glycogen44 259.1INS, CHGA, ACTC1, SYP, KRT7, ENO2
38dexamethasone44 50 29 1211.1INS, CP, CHGA, PRL, ACTC1, SYP
39hematoxylin448.0CHGA, CEACAM3, ACTC1, SYP, KRT7, ENO2
40cholesterol44 29 25 1210.8INS, SERPINA1, CP, CHGA, CEACAM3, SYP
41acth447.7INS, SERPINA1, CHGA, PRL, CEACAM3, SYP
42vegf447.6CP, CHGA, CEACAM3, ACTC1, SYP, KRT7
43paraffin447.6SERPINA1, CHGA, CEACAM3, ACTC1, SYP, KRT7
44lipid447.6INS, SERPINA1, CP, CHGA, SYP, KRT7
45creatinine447.5INS, SERPINA1, CP, CHGA, CEACAM3, ACTC1
46testosterone44 60 25 1210.2INS, CP, CHGA, PRL, ACTC1, SYP
47progesterone44 29 60 25 1211.1SERPINA1, CHGA, PRL, CEACAM3, ACTC1, SYP
48tyrosine447.0INS, SERPINA1, CHGA, CEACAM3, ACTC1, SYP
49glucose446.9INS, SERPINA1, CHGA, PRL, CEACAM3, ACTC1
50estrogen446.2ENO2, INS, SERPINA1, CP, CHGA, PRL

GO Terms for genes affiliated with Granulosa Cell Tumor of the Ovary

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Cellular components related to Granulosa Cell Tumor of the Ovary according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.4SERPINA1, CP, CHGA, PRL, INS
2extracellular spaceGO:0056158.0ENO2, ACTC1, CP, SERPINA1, INS

Biological processes related to Granulosa Cell Tumor of the Ovary according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:0069539.5SERPINA1, INS

Products for genes affiliated with Granulosa Cell Tumor of the Ovary

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Sources for Granulosa Cell Tumor of the Ovary

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