MCID: GRN022
MIFTS: 36

Granulosa Cell Tumor of the Ovary malady

Rare diseases, Cancer diseases categories

Aliases & Classifications for Granulosa Cell Tumor of the Ovary

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Granulosa Cell Tumor of the Ovary, Aliases & Descriptions:

Name: Granulosa Cell Tumor of the Ovary 41 60
Granulosa Theca Cell Tumor of the Ovary 41
Adult Granulosa Cell Tumor of the Ovary 41
 
Granulosa Theca Cell Tumor 41
Gct of the Ovary 41
Gtct 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases


Summaries for Granulosa Cell Tumor of the Ovary

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NIH Rare Diseases:41 Granulosa cell tumor of the ovary is a rare type of ovarian cancer that accounts for approximately 2% of all ovarian tumors. this type of tumor is known as a sex cord-stromal tumor and usually occurs in adults. granulosa cell tumors of the ovary cause higher than normal levels of estrogen in a woman's body.  the symptoms of this excess estrogen depend on the woman's menstrual status; the most common symptoms include early puberty for affected young girls, an increase in abdomen size or irregularities of menstrual cycles in premenopausal women, and abnormal uterine bleeding in postmenopausal women. the exact cause of granulosa cell tumors is unknown.  treatment consists of surgery to remove the tumor, and additional treatments may also be used depending on the extent of the tumor. last updated: 11/14/2011

MalaCards based summary: Granulosa Cell Tumor of the Ovary, also known as granulosa theca cell tumor of the ovary, is related to sertoli cell tumor and amenorrhea. An important gene associated with Granulosa Cell Tumor of the Ovary is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Cardiac Progenitor Differentiation and Selected targets of CREB1. The compounds 111in-pentetreotide and estracyt have been mentioned in the context of this disorder. Affiliated tissues include ovary, breast and bone.

Related Diseases for Granulosa Cell Tumor of the Ovary

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Diseases related to Granulosa Cell Tumor of the Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 129)
idRelated DiseaseScoreTop Affiliating Genes
1sertoli cell tumor30.9SYP, ENO2
2amenorrhea30.9PRL, INS
3breast cancer29.6KRT7, INS, CP, CEACAM3, SERPINA1, PRL
4hepatitis10.7
5peritonitis10.6
6somatostatinoma10.5CHGA
7melanotic neuroectodermal tumor10.5SYP
8fibroma10.5
9hypercalcemia10.5
10dysembryoplastic neuroepithelial tumor10.5SYP
11hemosiderosis10.5CP
12siderosis10.5CP
13central neurocytoma10.4SYP, CHGA
14ewing's family of tumors10.4ENO2
15rhabdoid tumor10.4SYP, ACTC1
16hyperprolactinemia10.4
17aromatase deficiency10.4
18leprechaunism10.4
19sertoli-leydig cell tumor10.4
20premature menopause10.4
21tuberous sclerosis10.4
22pancytopenia10.4
23hemangiopericytoma10.4
24leiomyoma10.4
25leydig cell tumor10.4
26gynandroblastoma10.4
27ovarian fibroma10.4
28monosomy 2210.4
29luteoma10.4
30islet cell tumor10.4CHGA, SYP
31glomus tumor10.4ACTC1, SYP
32endocrine gland cancer10.4SYP, CHGA
33neurofibroma10.3ACTC1, SYP
34empty sella syndrome10.3PRL
35spindle cell sarcoma10.3ACTC1, KRT7
36pituitary apoplexy10.3PRL
37acute respiratory distress syndrome10.3SERPINA1, CP
38pituitary carcinoma10.3PRL
39malignant fibroxanthoma10.3SERPINA1, ACTC1
40signet ring cell adenocarcinoma10.3CHGA, KRT7
41hyperinsulinemic hypoglycemia, familial, 210.3CHGA, INS
42giant cell tumor10.3CEACAM3, ACTC1
43pancreatic ductal carcinoma10.3CHGA, KRT7
44granular cell tumor10.3ENO2, SYP
45olfactory neuroblastoma10.3SYP, ENO2
46adrenocortical carcinoma10.3CHGA, SYP
47abrikosov's tumor10.3KRT7, ACTC1
48adrenal cortical adenoma10.3CHGA, SYP
49ganglioneuroblastoma10.3SYP, ENO2
50neuroectodermal tumor10.3SYP, ENO2

Graphical network of the top 20 diseases related to Granulosa Cell Tumor of the Ovary:



Diseases related to granulosa cell tumor of the ovary

Symptoms for Granulosa Cell Tumor of the Ovary

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Drugs & Therapeutics for Granulosa Cell Tumor of the Ovary

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Drug clinical trials:

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Genetic Tests for Granulosa Cell Tumor of the Ovary

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Anatomical Context for Granulosa Cell Tumor of the Ovary

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MalaCards organs/tissues related to Granulosa Cell Tumor of the Ovary:

31
Ovary, Breast, Bone, Liver, Lung, Adrenal gland

Animal Models for Granulosa Cell Tumor of the Ovary or affiliated genes

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Publications for Granulosa Cell Tumor of the Ovary

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Articles related to Granulosa Cell Tumor of the Ovary:

(show top 50)    (show all 140)
idTitleAuthorsYear
1
Parameters for predicting granulosa cell tumor of the ovary: a single center retrospective comparative study. (25339044)
2014
2
Granulosa cell tumor of the ovary with high FDG uptake. (23640219)
2013
3
Successful treatment of adult-type granulosa cell tumor of the ovary by palliative radiotherapy. (22175649)
2012
4
Primary amenorrhea due to juvenile granulosa-cell tumor of the ovary: a case report. (22353374)
2012
5
Delayed menopause due to granulosa cell tumor of the ovary. (22408338)
2011
6
Prolonged survival following maximal cytoreductive effort for peritoneal metastases from recurrent granulosa cell tumor of the ovary. (21998767)
2011
7
Granulosa cell tumor of the ovary: time to launch a new prospective trial. (21998755)
2011
8
Medico-legal observations concerning a mortal case of granulosa cell tumor of the ovary in an 8-month-old infant. (21843743)
2011
9
Synchronous adult-type granulosa cell tumor of the ovary with ovarian fibroma: a case report. (22335040)
2011
10
FOXL2 mutation and large-scale genomic imbalances in adult granulosa cell tumors of the ovary. (22200085)
2011
11
Granulosa cell tumor of the ovary: cytologic findings. (20715655)
2010
12
Mutation of FOXL2 in granulosa-cell tumors of the ovary. (19516027)
2009
13
Prognostic factors in adult granulosa cell tumor of the ovary. (19198715)
2009
14
Juvenile granulosa cell tumor of the ovary presenting with pleural effusion and ascites. (19225930)
2009
15
Cystic fluid and fine needle aspiration cytopathology of cystic adult granulosa cell tumor of the ovary: a case report. (18500005)
2008
16
Glucose metabolism and angiogenesis in granulosa cell tumors of the ovary: activation of Akt, expression of M2PK, TKTL1 and VEGF. (18394773)
2008
17
Juvenile granulosa cell tumor of the ovary associated with hypercalcemia. (17849133)
2008
18
Juvenile granulosa cell tumor of the ovary associated with tuberous sclerosis. (16516278)
2006
19
Clinicopathological prognostic factors of adult granulosa cell tumor of the ovary--a study of 37 cases. (16366090)
2005
20
Monosomy 22 as a diagnostic aid in a case of late recurrence of adult granulosa cell tumor of the ovary. (15588863)
2005
21
Multifocal intrafollicular granulosa cell tumor of the ovary associated with an unusual germline p53 mutation. (15073606)
2004
22
Granulosa cell tumor of the ovary metastasizing to adrenal gland 13 years after initial diagnosis--diagnostic difficulties and immunohistochemical study]. (15058173)
2003
23
Granulosa cell tumor of the ovary: common findings and unusual appearances on CT and MR. (12439311)
2002
24
Juvenile granulosa cell tumor of the ovary: imprint cytology findings. (12462106)
2002
25
Hyperprolactinemia complicating juvenile granulosa cell tumor of the ovary. (11531301)
2001
26
Bone metastasis from a granulosa cell tumor of the ovary. (11606104)
2001
27
Case 5: gynecological. Granulosa cell tumor of the ovary with endometrial carcinoma. (10811416)
2000
28
Severe hypercalcemia in association with a juvenile granulosa cell tumor of the ovary. (10742079)
2000
29
Masculinizing granulosa cell tumor of the ovary in a postmenopausal woman. A case report. (10509308)
1999
30
Radiation treatment of advanced or recurrent granulosa cell tumor of the ovary. (10094877)
1999
31
Granulosa cell tumor of the ovary. (9880981)
1998
32
Prognostic factors in adult granulosa cell tumor of the ovary. (9149022)
1997
33
Management of advanced juvenile granulosa cell tumor of the ovary. (9038278)
1997
34
Juvenile granulosa cell tumor of the ovary in infants: a clinicopathologic study of three cases and review of the literature. (9165474)
1997
35
The management of granulosa cell tumor of the ovary--a case history. (8839909)
1996
36
Recurrent granulosa cell tumor of the ovary 37 years after initial diagnosis: a case report and review of the literature. (8774662)
1996
37
Juvenile granulosa-cell tumor of the ovary - interphase cytogenetics for chromosome-12 and chromosome-x and flow cytometric DNA-ploidy study. (21552888)
1995
38
Luteinized adult granulosa cell tumors of the ovary: a report of four cases. (7814191)
1994
39
Granulosa cell tumor of the ovary with diffuse true hepatic differentiation simulating stromal luteinization. (7680545)
1993
40
Congenital bilateral juvenile granulosa cell tumor of the ovary in leprechaunism: a case report. (8247952)
1993
41
Granulosa cell tumor of the ovary. (2178047)
1990
42
Prognostic value of flow cytometric DNA content analysis in granulosa cell tumor of the ovary. (2302667)
1990
43
Juvenile granulosa cell tumor of the ovary in children: a clinical study of 15 cases. (3373268)
1988
44
Cystic juvenile granulosa cell tumor of the ovary. (3176932)
1988
45
A clinicopathologic study of 92 cases of granulosa cell tumor of the ovary with special reference to the factors influencing prognosis. (1109770)
1975
46
Granulosa-cell tumor of the ovary. Report of case. (13766011)
1961
47
Granulosa cell tumor of the ovary. (20250086)
1947
48
Granulosa-cell tumor of the ovary. (21001409)
1946
49
Granulosa cell tumor of the ovary; a clinical and pathologic review of 62 cases. (21005311)
1945
50
GRANULOSA CELL TUMOR OF THE OVARY: REPORT OF A CASE. (17857589)
1940

Variations for Granulosa Cell Tumor of the Ovary

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Expression for genes affiliated with Granulosa Cell Tumor of the Ovary

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Search GEO for disease gene expression data for Granulosa Cell Tumor of the Ovary.

Pathways for genes affiliated with Granulosa Cell Tumor of the Ovary

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Pathways related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ACTC1, INS
2
Show member pathways
FOXA transcription factor networks36
9.5SERPINA1, INS
39.5INS, PRL

Compounds for genes affiliated with Granulosa Cell Tumor of the Ovary

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Compounds related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1111in-pentetreotide439.8SYP, CHGA
2estracyt439.8ENO2, CHGA
3smcc439.7ENO2, CHGA, SYP
4metanephrine43 2410.6CHGA, ENO2
5l-amino acid439.6SYP, ENO2, CHGA
6homovanillic acid43 2410.5CHGA, ENO2, PRL
7streptozotocin439.5INS, SYP, CHGA
8flutamide43 59 1211.5CHGA, PRL, ENO2
9s 100439.4SYP, ACTC1, CHGA, ENO2
10reticulin439.4SYP, KRT7, ACTC1
11silver439.4ENO2, SYP, CHGA
125-hydroxyindoleacetic acid43 2410.3CEACAM3, CHGA, ENO2
13methanol43 2410.3KRT7, ACTC1, CHGA
14levodopa43 1210.2PRL, CHGA, CP
155-hydroxytryptamine439.2PRL, CHGA, SYP, ENO2
16uric acid43 2410.1INS, CP, ENO2
17ribonucleic acid439.1CHGA, ENO2, PRL, ACTC1
18epinephrine43 24 1211.0CP, CHGA, INS, PRL
19octreotide43 59 28 1212.0CHGA, PRL, INS, ENO2
20amine439.0ENO2, SYP, CHGA
21mucicarmine438.8ACTC1, SYP, KRT7, CEACAM3
22thyroxine43 249.8CP, PRL, CEACAM3, INS
23dopamine43 28 24 1211.8PRL, CHGA, CP, SYP, ENO2
24steroid438.7CEACAM3, ACTC1, CHGA, SYP, PRL
25norepinephrine43 24 1210.7PRL, SYP, CHGA, INS, ENO2
26fibrinogen438.6CHGA, INS, CEACAM3, CP, SERPINA1
27formaldehyde43 249.6ENO2, KRT7, SYP, ACTC1, CHGA
28glutamate438.6SYP, INS, CP, ENO2, CHGA
29b 723438.5CEACAM3, ACTC1, SYP, KRT7, CHGA
30sialic acid438.5ENO2, KRT7, CP, CEACAM3
31nitric oxide43 24 1210.5ENO2, CEACAM3, CHGA, SERPINA1, SYP
32lactate438.4ENO2, CEACAM3, CHGA, INS, CP
33iron43 249.4SERPINA1, CP, ACTC1, KRT7, ENO2
34oxygen43 249.3CEACAM3, CP, ACTC1, ENO2, SERPINA1, CHGA
35arginine438.2CP, CHGA, PRL, KRT7, INS
36retinoic acid43 249.1CP, CHGA, ENO2, KRT7, SYP, ACTC1
37glycogen43 249.1INS, ACTC1, CHGA, KRT7, ENO2, SYP
38dexamethasone43 49 28 1211.1ACTC1, CHGA, PRL, SYP, CP, INS
39hematoxylin438.0KRT7, ENO2, SYP, CHGA, CEACAM3, ACTC1
40cholesterol43 28 24 1210.8INS, SERPINA1, CP, ENO2, SYP, CEACAM3
41acth437.7SYP, CEACAM3, PRL, CHGA, ENO2, SERPINA1
42vegf437.6ENO2, KRT7, SYP, ACTC1, CP, CHGA
43paraffin437.6ACTC1, CEACAM3, KRT7, ENO2, CHGA, SERPINA1
44lipid437.6SYP, KRT7, CP, ENO2, SERPINA1, INS
45creatinine437.5SYP, CHGA, CEACAM3, ACTC1, INS, ENO2
46testosterone43 59 24 1210.2SYP, CHGA, CP, INS, KRT7, ENO2
47progesterone43 28 59 24 1211.1ENO2, ACTC1, SYP, SERPINA1, CEACAM3, PRL
48tyrosine437.0CHGA, ENO2, INS, SERPINA1, KRT7, SYP
49glucose436.9INS, KRT7, ACTC1, CEACAM3, PRL, ENO2
50estrogen436.2CP, CHGA, PRL, CEACAM3, ACTC1, SYP

GO Terms for genes affiliated with Granulosa Cell Tumor of the Ovary

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Cellular components related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055768.4INS, SERPINA1, CP, CHGA, PRL
2extracellular spaceGO:00056158.0INS, SERPINA1, CP, ACTC1, ENO2

Biological processes related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:00069539.5SERPINA1, INS

Products for genes affiliated with Granulosa Cell Tumor of the Ovary

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Sources for Granulosa Cell Tumor of the Ovary

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