GTCT
MCID: GRN022
MIFTS: 41

Granulosa Cell Tumor of the Ovary (GTCT) malady

Gastrointestinal diseases, Cancer diseases categories

Summaries for Granulosa Cell Tumor of the Ovary

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Granulosa cell tumor of the ovary is a rare type of ovarian cancer that accounts for approximately 2% of all ovarian tumors. this type of tumor is known as a sex cord-stromal tumor and usually occurs in adults. granulosa cell tumors of the ovary cause higher than normal levels of estrogen in a woman's body.  the symptoms of this excess estrogen depend on the woman's menstrual status; the most common symptoms include early puberty for affected young girls, an increase in abdomen size or irregularities of menstrual cycles in premenopausal women, and abnormal uterine bleeding in postmenopausal women. the exact cause of granulosa cell tumors is unknown.  treatment consists of surgery to remove the tumor, and additional treatments may also be used depending on the extent of the tumor. last updated: 11/14/2011

MalaCards: Granulosa Cell Tumor of the Ovary, also known as granulosa theca cell tumor of the ovary, is related to hepatitis and amenorrhea. An important gene associated with Granulosa Cell Tumor of the Ovary is FOXL2 (forkhead box L2), and among its related pathways are 14-3-3 Induced Apoptosis and Glioma. The compounds serine and tamoxifen have been mentioned in the context of this disorder. Affiliated tissues include ovary, and related mouse phenotypes are vision/eye and renal/urinary system.

Aliases & Classifications for Granulosa Cell Tumor of the Ovary

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42NIH Rare Diseases, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

granulosa cell tumor of the ovary 42 60
granulosa theca cell tumor of the ovary 42
adult granulosa cell tumor of the ovary 42
gastrointestinal carcinoid tumor 60
granulosa theca cell tumor 42
gct of the ovary 42
gtct 42


Related Diseases for Granulosa Cell Tumor of the Ovary

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17GeneCards, 18GeneDecks
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Diseases related to Granulosa Cell Tumor of the Ovary via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 256)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.0CP, SERPINA1
2amenorrhea30.7INS, PRL
3sertoli-leydig cell tumor30.5KRT7
4hyperprolactinemia30.5PRL
5leiomyoma30.5VIM, ACTC1
6tuberous sclerosis30.5SYP, VIM
7hemangiopericytoma30.5ACTC1, VIM
8sertoli cell tumor30.5VIM, SYP, ENO2
9endometrial carcinoma30.4CHGA, KRT7, BCL2, CEACAM3, TP53
10breast cancer30.4VIM, FAS, SYP, CHGA, VEGFA, KRT7
11somatostatinoma30.1CHGA
12pancreatitis30.1INS, SERPINA1
13neuroendocrine tumor30.1SYP, CHGA, ENO2, CEACAM3
14peritonitis10.6
15hypercalcemia10.5
16leydig cell tumor10.5
17pancytopenia10.3
18premature menopause10.3
19hepatitis a10.3
20luteoma10.3
21bone giant cell tumor10.1
22gastrointestinal neuroendocrine tumor10.1
23nasopharyngitis10.0TKTL1
24osteoarthritis10.0CFLAR
25amyotrophic lateral sclerosis10.0SYP
26arthritis10.0CFLAR
27multiple sclerosis10.0CFLAR
28dilated cardiomyopathy10.0ACTC1
29melanotic neuroectodermal tumor10.0SYP
30cystadenocarcinoma10.0CEACAM3
31phaeochromocytoma10.0CHGA
32deficiency anemia10.0CP
33thymoma10.0CEACAM3
34fasciitis10.0ACTC1
35pneumonia10.0SERPINA1
36cervical intraepithelial neoplasia10.0CFLAR
37premature ovarian failure10.0FOXL2
38psoriasis10.0SERPINA1
39dysembryoplastic neuroepithelial tumor10.0SYP
40wilson disease10.0CP
41hepatitis b10.0SERPINA1
42cerebral primitive neuroectodermal tumor10.0ENO2
43pneumoconiosis10.0CP
44anaplastic large cell lymphoma10.0ENO2
45herpes simplex10.0CFLAR
46neutropenia10.0CP
47hyperparathyroidism10.0CHGA
48mixed cell type cancer10.0KRT7
49nephrotic syndrome10.0SERPINA1
50bronchitis10.0SERPINA1

Graphical network of the top 20 diseases related to Granulosa Cell Tumor of the Ovary:



Diseases related to granulosa cell tumor of the ovary

Clinical Features for Granulosa Cell Tumor of the Ovary

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Drugs & Therapeutics for Granulosa Cell Tumor of the Ovary

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Genetic Tests for Granulosa Cell Tumor of the Ovary

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Anatomical Context for Granulosa Cell Tumor of the Ovary

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32MalaCards
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MalaCards organs/tissues related to Granulosa Cell Tumor of the Ovary:

32
Ovary

Animal Models for Granulosa Cell Tumor of the Ovary or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Granulosa Cell Tumor of the Ovary:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053919.9VIM, FOXL2, CP
2MP:00053679.8KRT7, CHGA
3MP:00053799.4FOXL2, FAS, BCL2, TP53
4MP:00053769.3FOXL2, PRL, INS, ACTC1, CP
5MP:00053698.9INS, CFLAR, ACTC1, TP53
6MP:00053898.8TP53, BCL2, VEGFA, PRL, FAS, FOXL2
7MP:00053708.4CP, TP53, INS, VEGFA, PRL, FAS
8MP:00053857.6VEGFA, CHGA, FAS, VIM, INS, CFLAR
9MP:00053877.1VEGFA, PRL, FAS, VIM, INS, TKTL1
10MP:00053787.1VIM, FOXL2, FAS, CHGA, VEGFA, INS
11MP:00107687.1PKM, FAS, FOXL2, VIM, CHGA, VEGFA
12MP:00036316.7VIM, FAS, PRL, SYP, VEGFA, INS
13MP:00053846.4CP, VIM, FOXL2, FAS, VEGFA, INS

Publications for Granulosa Cell Tumor of the Ovary

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Genetic Variations for Granulosa Cell Tumor of the Ovary

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Expression for genes affiliated with Granulosa Cell Tumor of the Ovary

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Granulosa Cell Tumor of the Ovary

Search GEO for disease gene expression data for Granulosa Cell Tumor of the Ovary.

Pathways for genes affiliated with Granulosa Cell Tumor of the Ovary

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51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems
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Pathways related to Granulosa Cell Tumor of the Ovary according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.7TP53, BCL2
2
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9.6TP53, INS
39.6CP, VEGFA, PKM
4
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9.5CFLAR, BCL2, TP53
5
Apoptosis and survival Apoptotic TNF-family pathways
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9.4TP53, BCL2, FAS
6
Transcription P53 signaling pathway
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9.3VEGFA, BCL2, TP53
7
Apoptosis and survival Caspase cascade
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9.3VIM, FAS, CFLAR, BCL2
8
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9.2FAS, CFLAR, BCL2, TP53
99.1FAS, VEGFA, BCL2, TP53
10
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9.1FAS, VEGFA, BCL2, TP53
119.0TP53, BCL2, VEGFA, VIM
12
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8.9TP53, BCL2, CFLAR, PRL, FAS
138.6TP53, BCL2, INS, VEGFA, PRL
148.5VEGFA, INS, ENO2, BCL2

Compounds for genes affiliated with Granulosa Cell Tumor of the Ovary

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44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB
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Compounds related to Granulosa Cell Tumor of the Ovary according to GeneCards/GeneDecks:

(show top 50)    (show all 125)
idCompoundScoreTop Affiliating Genes
1serine4410.2SYP, CFLAR, PKM
2tamoxifen44 49 28 1113.0CEACAM3, CHGA
3h2o2449.8SYP, VIM, CFLAR, CP
4tanshinone iia449.8BCL2, FAS, TP53
5streptozotocin449.7SYP, INS, CHGA
6reticulin449.6ACTC1, KRT7, SYP, VIM
7ly294002449.6CFLAR, VEGFA, BCL2
8noxa449.5TP53, BCL2, CFLAR, FAS
9smcc449.5SYP, CHGA, ENO2
10etoposide44 49 59 1112.5VIM, FAS, CHGA, CFLAR, BCL2
11depsipeptide449.5FAS, CFLAR, BCL2, TP53
12suberoylanilide hydroxamic acid449.4FAS, TP53, BCL2, CFLAR
13dutp449.4FAS, SYP, CFLAR, BCL2, TP53
14n-(4-hydroxyphenyl)retinamide449.3BCL2, TP53, CFLAR, VIM
15oxygen44 2410.3CEACAM3, SERPINA1, CHGA, FAS, CFLAR
16glycogen44 2410.2ACTC1, KRT7, INS, CHGA, SYP
17s 100449.2ACTC1, ENO2, VIM, CHGA, SYP
18oxaliplatin44 49 1111.1CFLAR, FAS, TP53, VEGFA
19mg 13244 5910.1FAS, TP53, BCL2, CFLAR, VEGFA
20mucicarmine449.0VIM, SYP, KRT7, ACTC1, CEACAM3
21octreotide44 59 28 1112.0CHGA, ENO2, INS, PRL
22paclitaxel44 49 1111.0FAS, TP53, BCL2, CFLAR, VEGFA, CHGA
235fluorouracil448.9BCL2, FAS, CFLAR, CEACAM3, TP53
24arsenite44 249.8BCL2, CFLAR, TP53, VEGFA, FAS
25b 723448.8SYP, ACTC1, CHGA, CEACAM3, KRT7, VIM
265-hydroxytryptamine448.8ENO2, SYP, PRL, VIM, CHGA
27adriamycin448.7TP53, CEACAM3, CFLAR, BCL2, VIM, FAS
28rapamycin448.7VIM, BCL2, CFLAR, VEGFA, INS, FAS
29carboplatin44 49 1110.6BCL2, TP53, ENO2, VEGFA, CHGA
30dexamethasone44 49 28 1111.6BCL2, ENO2, INS, VEGFA, FAS
31docetaxel44 49 59 1111.6CFLAR, ENO2, VEGFA, BCL2, TP53
32formaldehyde44 249.6ACTC1, ENO2, SYP, CHGA, VIM, KRT7
33actinomycin d448.5BCL2, TP53, CFLAR, VEGFA, FAS, VIM
34thymidylate448.5CEACAM3, BCL2, VEGFA, FAS, VIM, TP53
355-aza-2deoxycytidine448.4TP53, VIM, FAS, CFLAR, KRT7
36creatinine448.4CEACAM3, SERPINA1, ACTC1, INS, CHGA, SYP
37glucose448.3ACTC1, SERPINA1, TKTL1, CFLAR, KRT7, PKM
38doxorubicin44 49 1110.3BCL2, CEACAM3, CFLAR, TP53, VEGFA, VIM
39hematoxylin448.0CHGA, ENO2, CEACAM3, VIM, ACTC1, SYP
40acth448.0CEACAM3, ENO2, SERPINA1, INS, CHGA, SYP
41arginine448.0TP53, KRT7, INS, CHGA, PRL, CP
42cisplatin44 49 59 1111.0BCL2, FAS, SYP, CHGA, TP53, CFLAR
43lactate447.6INS, ENO2, CP, CHGA, CEACAM3, PKM
44lipid447.5CP, SERPINA1, VIM, SYP, CHGA, CFLAR
45retinoic acid44 248.1ENO2, ACTC1, KRT7, CFLAR, CHGA, TP53
46testosterone44 59 11 2410.1ACTC1, ENO2, CP, PRL, VIM, KRT7
47progesterone44 59 28 11 2410.7TP53, ENO2, SERPINA1, ACTC1, KRT7, CHGA
48tyrosine446.4VEGFA, INS, FAS, SYP, PKM, CEACAM3
49paraffin446.4VIM, CEACAM3, TP53, BCL2, ENO2, KRT7
50vegf446.1CP, CEACAM3, BCL2, ENO2, ACTC1, KRT7

GO Terms for genes affiliated with Granulosa Cell Tumor of the Ovary

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16Gene Ontology
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Cellular components related to Granulosa Cell Tumor of the Ovary according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1death-inducing signaling complexGO:03126410.0CFLAR, FAS
2secretory granuleGO:0301419.5VEGFA, CHGA, PRL
3extracellular vesicular exosomeGO:0700629.4VIM, PKM, ACTC1
4extracellular regionGO:0055768.3CP, SERPINA1, INS, VEGFA, CHGA, PRL

Biological processes related to Granulosa Cell Tumor of the Ovary according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1renal system processGO:00301410.0BCL2, FAS
2regulation of transmembrane transporter activityGO:0228989.9BCL2, INS
3regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012399.9FAS, CFLAR
4B cell lineage commitmentGO:0023269.9TP53, BCL2
5ovarian follicle developmentGO:0015419.7FOXL2, VEGFA, BCL2
6regulation of mitochondrial membrane permeabilityGO:0469029.7TP53, BCL2
7neuron apoptotic processGO:0514029.6TP53, BCL2, FAS
8positive regulation of protein autophosphorylationGO:0319549.3INS, VEGFA
9positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.3VEGFA, INS, TP53
10negative regulation of apoptotic processGO:0430668.8TP53, BCL2, CFLAR, VEGFA, FAS

Molecular functions related to Granulosa Cell Tumor of the Ovary according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020208.5INS, CFLAR, SERPINA1, BCL2, TP53
2identical protein bindingGO:0428027.8TP53, VIM, FAS, SYP, VEGFA, INS
3protein bindingGO:0055156.5FOXL2, FAS, PRL, PKM, VEGFA, INS

Products for genes affiliated with Granulosa Cell Tumor of the Ovary

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Sources for Granulosa Cell Tumor of the Ovary

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet