MCID: GRN022
MIFTS: 41

Granulosa Cell Tumor of the Ovary

Categories: Rare diseases

Aliases & Classifications for Granulosa Cell Tumor of the Ovary

MalaCards integrated aliases for Granulosa Cell Tumor of the Ovary:

Name: Granulosa Cell Tumor of the Ovary 49 69
Adult Granulosa Cell Tumor of the Ovary 49
Granulosa Theca Cell Tumor of the Ovary 49
Granulosa Theca Cell Tumor 49
Gct of the Ovary 49
Gtct 49

Classifications:



External Ids:

UMLS 69 C1370419

Summaries for Granulosa Cell Tumor of the Ovary

NIH Rare Diseases : 49 Granulosa celltumor of the ovary is a rare type of ovarian cancer that accounts for approximately 2% of all ovarian tumors. This type of tumor is known as a sex cord-stromal tumor and usually occurs in adults. Granulosa cell tumors of the ovary cause higher than normal levels of estrogen in a woman's body.  The symptoms of this excess estrogen depend on the woman's menstrual status; the most common symptoms include early puberty for affected young girls, an increase in abdomen size or irregularities of menstrual cycles in premenopausal women, and abnormal uterine bleeding in postmenopausal women. The exact cause of granulosa cell tumors is unknown.  Treatment consists of surgery to remove the tumor, and additional treatments may also be used depending on the extent of the tumor. Last updated: 1/7/2016

MalaCards based summary : Granulosa Cell Tumor of the Ovary, also known as adult granulosa cell tumor of the ovary, is related to gynandroblastoma and sertoli cell tumor. An important gene associated with Granulosa Cell Tumor of the Ovary is GNAI2 (G Protein Subunit Alpha I2), and among its related pathways/superpathways is HIF-1 signaling pathway. The drugs Paclitaxel and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include ovary, endothelial and breast, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Granulosa Cell Tumor of the Ovary

Diseases related to Granulosa Cell Tumor of the Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 255)
# Related Disease Score Top Affiliating Genes
1 gynandroblastoma 30.8 FOXL2 VIM
2 sertoli cell tumor 30.3 INHA SYP VIM
3 maligant granulosa cell tumor of the ovary 12.3
4 juvenile type testicular granulosa cell tumor 10.6
5 lymphangiectasis 10.6 ACTC1 VIM
6 glomangiomyoma 10.6 ACTC1 VIM
7 angiolipoma 10.6 ACTC1 VIM
8 intravascular papillary endothelial hyperplasia 10.6 ACTC1 VIM
9 cutaneous leiomyosarcoma 10.6 ACTC1 VIM
10 breast neuroendocrine neoplasm 10.6 ERBB2 SYP
11 spindle cell lipoma 10.6 ACTC1 VIM
12 malignant giant cell tumor 10.6 ACTC1 TP53
13 bednar tumor 10.6 ENO2 VIM
14 uterine corpus serous adenocarcinoma 10.5 ERBB2 TP53
15 primitive neuroectodermal tumor of the cervix uteri 10.5 ENO2 VIM
16 glioma susceptibility 1 10.5 ERBB2 TP53
17 malignant sertoli cell tumor 10.5 ENO2 SYP
18 rhabdoid meningioma 10.5 SYP VIM
19 epulis 10.5 ENO2 VIM
20 cutaneous ganglioneuroma 10.5 ENO2 SYP
21 intracystic papillary adenoma 10.5 ERBB2 PRL
22 syringocystadenoma papilliferum 10.5 ACTC1 VIM
23 pancreatic somatostatinoma 10.5 ENO2 SYP
24 extrahepatic bile duct adenocarcinoma 10.5 ENO2 SYP
25 congenital granular cell tumor 10.5 ENO2 SERPINA1
26 orbital cancer 10.5 ENO2 SYP
27 non-proliferative fibrocystic change of the breast 10.5 ERBB2 TP53
28 ovarian carcinosarcoma 10.5 ENO2 SYP
29 ureter small cell carcinoma 10.5 CHGA SYP
30 choriocarcinoma of ovary 10.5 ENO2 PRL
31 esophageal neuroendocrine tumor 10.4 CHGA SYP
32 large cell medulloblastoma 10.4 SYP VIM
33 angiocentric glioma 10.4 ACTC1 SYP VIM
34 ossifying fibromyxoid tumor 10.4 ACTC1 ENO2 VIM
35 perivascular epithelioid cell tumor 10.4 ACTC1 SYP VIM
36 epithelioid leiomyosarcoma 10.4 ACTC1 ENO2 VIM
37 intracranial primitive neuroectodermal tumor 10.4 CHGA ENO2
38 dermatofibrosarcoma protuberans 10.4 ACTC1 TP53 VIM
39 subependymal glioma 10.4 ENO2 SYP
40 inflammatory myofibroblastic tumor 10.4 ACTC1 TP53 VIM
41 peritoneal serous adenocarcinoma 10.4 CHGA SYP
42 liver angiosarcoma 10.4 ENO2 TP53 VIM
43 olfactory groove meningioma 10.4 CHGA TP53
44 papillary tumor of the pineal region 10.4 ENO2 SYP VIM
45 pleomorphic adenoma carcinoma 10.4 ENO2 ERBB2 TP53
46 astroblastoma 10.4 ENO2 SYP VIM
47 melanotic neuroectodermal tumor 10.4 ENO2 SYP VIM
48 gastrointestinal neuroendocrine tumor 10.4 CHGA SYP
49 central nervous system primitive neuroectodermal neoplasm 10.4 ENO2 SYP TP53
50 cerebellum cancer 10.4 ENO2 SYP TP53

Graphical network of the top 20 diseases related to Granulosa Cell Tumor of the Ovary:



Diseases related to Granulosa Cell Tumor of the Ovary

Symptoms & Phenotypes for Granulosa Cell Tumor of the Ovary

MGI Mouse Phenotypes related to Granulosa Cell Tumor of the Ovary:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.97 GNAI2 INHA INS ACTC1 CHGA CP
2 homeostasis/metabolism MP:0005376 9.93 GNAI2 INHA INS ACTC1 CHGA KRT7
3 endocrine/exocrine gland MP:0005379 9.86 FOXL2 GNAI2 INHA INS CHGA PRL
4 normal MP:0002873 9.56 GNAI2 INHA INS ACTC1 SYP TP53
5 reproductive system MP:0005389 9.23 VIM FOXL2 INHA INS CHGA PRL

Drugs & Therapeutics for Granulosa Cell Tumor of the Ovary

Drugs for Granulosa Cell Tumor of the Ovary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Etoposide Approved Phase 2 33419-42-0 36462
3
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
4
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
5
Bleomycin Approved, Investigational Phase 2 11056-06-7 5360373
6
Bevacizumab Approved, Investigational Phase 2 216974-75-3
7
Ketoconazole Approved, Investigational Phase 2 65277-42-1 3823 47576
8
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
9 Albumin-Bound Paclitaxel Phase 2
10 Antimitotic Agents Phase 2
11 Antineoplastic Agents, Phytogenic Phase 2
12 Topoisomerase Inhibitors Phase 2
13 Anti-Bacterial Agents Phase 2
14 Etoposide phosphate Phase 2
15 Antibiotics, Antitubercular Phase 2
16 Mitogens Phase 2
17 Angiogenesis Inhibitors Phase 2
18 Angiogenesis Modulating Agents Phase 2
19 Antibodies, Monoclonal Phase 2
20 Endothelial Growth Factors Phase 2
21 Immunoglobulins Phase 2
22 Antibodies Phase 2
23 Steroid Synthesis Inhibitors Phase 2
24 Cytochrome P-450 CYP3A Inhibitors Phase 2
25 Cytochrome P-450 Enzyme Inhibitors Phase 2
26 Hormone Antagonists Phase 2
27 Hormones Phase 2
28 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
29 Anti-Infective Agents Phase 2
30 Antifungal Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Paclitaxel in Treating Patients With Ovarian Stromal Cancer Completed NCT00006227 Phase 2 Paclitaxel
2 Paclitaxel and Carboplatin or Bleomycin Sulfate, Etoposide Phosphate, and Cisplatin in Treating Patients With Advanced or Recurrent Sex Cord-Ovarian Stromal Tumors Recruiting NCT01042522 Phase 2 Carboplatin;Cisplatin;Etoposide Phosphate;Paclitaxel
3 Bevacizumab in Treating Patients With Recurrent Sex Cord-Stromal Tumors of the Ovary Active, not recruiting NCT00748657 Phase 2
4 Ketoconazole as Inhibitor of the Enzyme CYP17 in Locally Advanced or Disseminated Granulosa Cell Tumour of Ovary Terminated NCT01584297 Phase 2 Ketoconazole

Search NIH Clinical Center for Granulosa Cell Tumor of the Ovary

Genetic Tests for Granulosa Cell Tumor of the Ovary

Anatomical Context for Granulosa Cell Tumor of the Ovary

MalaCards organs/tissues related to Granulosa Cell Tumor of the Ovary:

38
Ovary, Endothelial, Breast, Adrenal Gland, Liver, Lung, Bone

Publications for Granulosa Cell Tumor of the Ovary

Articles related to Granulosa Cell Tumor of the Ovary:

(show top 50) (show all 156)
# Title Authors Year
1
TERT promoter mutation in adult granulosa cell tumor of the ovary. ( 29449679 )
2018
2
Retroperitoneal nodal metastasis in primary adult type granulosa cell tumor of the ovary: Can routine lymphadenectomy be omitted? ( 29055817 )
2017
3
Clinical and genetic analysis of recurrent adult-type granulosa cell tumor of the ovary: Persistent preservation of heterozygous c.402C>G FOXL2 mutation. ( 28594898 )
2017
4
Postmenopausal mild hirsutism and hyperandrogenemia due to granulosa cell tumor of the ovary: a case report. ( 28851436 )
2017
5
Stromal p16 Overexpression in Adult Granulosa Cell Tumors of the Ovary. ( 28476811 )
2017
6
Juvenile Granulosa Cell Tumor of the Ovary: A Clinicopathologic Study. ( 27702598 )
2017
7
Pathogenesis and treatment of adult-type granulosa cell tumor of the ovary. ( 28276867 )
2017
8
Prognostic factors for recurrence in early stage adult granulosa cell tumor of the ovary. ( 27324782 )
2016
9
Cytomorphology and Clinicopathologic Correlation of the Recurrent and Metastatic Adult Granulosa Cell Tumor of the Ovary: A Retrospective Review. ( 27493080 )
2016
10
Fine needle aspiration cytology of cystic primary adult granulosa cell tumor of the ovary: Potential diagnostic pitfalls with other cystic ovarian lesions. ( 26956549 )
2016
11
Molecularly Defined Adult Granulosa Cell Tumor of the Ovary: The Clinical Phenotype. ( 27297428 )
2016
12
Aggressive Granulosa Cell Tumor of the Ovary with Rapid Recurrence: a Case Report and Review of the Literature. ( 27323838 )
2016
13
Granulosa cell tumor of the ovary. ( 28757730 )
2016
14
A recurrent granulosa cell tumor of the ovary 25 years after the initial diagnosis: A case report. ( 25979613 )
2015
15
Metastasis of the liver with a granulosa cell tumor of the ovary: A case report. ( 25621056 )
2015
16
Adult granulosa cell tumor of the ovary: a retrospective study of 37 cases. ( 25556264 )
2014
17
Aromatase Inhibitor Therapy As Effective Rescue in a Patient With Tamoxifen-Refractory Metastatic Granulosa Cell Tumor of the Ovary. ( 24934781 )
2014
18
Parameters for predicting granulosa cell tumor of the ovary: a single center retrospective comparative study. ( 25339044 )
2014
19
Granulosa cell tumor of the ovary--an incidental finding during caesarean section--a rare case report. ( 25219997 )
2014
20
Fertility-sparing surgery for advanced juvenile granulosa cell tumor of the ovary. ( 24656706 )
2014
21
Recurrence of adult granulosa cell tumor of the ovary: experience at a tertiary care center. ( 24630126 )
2014
22
The incidence of endometrial hyperplasia and cancer in 1031 patients with a granulosa cell tumor of the ovary: long-term follow-up in a population-based cohort study. ( 24257556 )
2013
23
Letrozole efficacy in the treatment of granulosa cell tumor of the ovary: a case report. ( 24051926 )
2013
24
Granulosa cell tumor of the ovary with high FDG uptake. ( 23640219 )
2013
25
Primary amenorrhea due to juvenile granulosa-cell tumor of the ovary: a case report. ( 22353374 )
2012
26
Granulosa cell tumor of the ovary after long-term use of tamoxifen and toremifene. ( 22612286 )
2012
27
Ruptured granulosa cell tumor of the ovary as a cause of acute abdomen in postmenopausal woman. ( 22973526 )
2012
28
Management of peritoneal dissemination of recurrences granulosa cell tumor of the ovary. ( 23268102 )
2012
29
A case of granulosa cell tumor of the ovary detected from metastatic foci. ( 23327064 )
2012
30
Successful treatment of adult-type granulosa cell tumor of the ovary by palliative radiotherapy. ( 22175649 )
2012
31
Medico-legal observations concerning a mortal case of granulosa cell tumor of the ovary in an 8-month-old infant. ( 21843743 )
2011
32
FOXL2 mutation and large-scale genomic imbalances in adult granulosa cell tumors of the ovary. ( 22200085 )
2011
33
Synchronous adult-type granulosa cell tumor of the ovary with ovarian fibroma: a case report. ( 22335040 )
2011
34
Role of adjuvant radiotherapy in granulosa cell tumors of the ovary. ( 20472362 )
2011
35
Delayed menopause due to granulosa cell tumor of the ovary. ( 22408338 )
2011
36
Prognostic significance of FOXL2 mutation and mRNA expression in adult and juvenile granulosa cell tumors of the ovary. ( 21623383 )
2011
37
Granulosa cell tumor of the ovary: time to launch a new prospective trial. ( 21998755 )
2011
38
Prolonged survival following maximal cytoreductive effort for peritoneal metastases from recurrent granulosa cell tumor of the ovary. ( 21998767 )
2011
39
Granulosa cell tumor of the ovary: cytologic findings. ( 20715655 )
2010
40
The FOXL2 C134W mutation is characteristic of adult granulosa cell tumors of the ovary. ( 20693978 )
2010
41
Granulosa cell tumor of the ovary and antecedent of adjuvant tamoxifen use for breast cancer. ( 20704728 )
2010
42
Unusual virilization in girls with juvenile granulosa cell tumors of the ovary is related to intratumoral aromatase deficiency. ( 20395670 )
2010
43
Late recurrence of granulosa cell tumor of the ovary with synchronous gastric signet-ring cell carcinoma. ( 21229651 )
2010
44
Fine needle aspiration of metastatic adult granulosa cell tumor of the ovary: a case report. ( 21053572 )
2010
45
Neoadjuvant bevacizumab in a granulosa cell tumor of the ovary: a case report. ( 21115938 )
2010
46
Unusual presentation of granulosa cell tumor of the ovary. ( 20713871 )
2010
47
Nearly 30 Years of Treatment for Recurrent Granulosa Cell Tumor of the Ovary: A Case Report and Review of the Literature. ( 20740152 )
2010
48
Granulosa cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 21 cases. ( 20349790 )
2010
49
Isolated breast metastasis from granulosa cell tumor of the ovary. ( 19306013 )
2009
50
The new molecular biology of granulosa cell tumors of the ovary. ( 19725933 )
2009

Variations for Granulosa Cell Tumor of the Ovary

ClinVar genetic disease variations for Granulosa Cell Tumor of the Ovary:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 GNAI2 NM_002070.3(GNAI2): c.535C> T (p.Arg179Cys) single nucleotide variant Pathogenic rs137853226 GRCh37 Chromosome 3, 50293694: 50293694
2 GNAI2 NM_002070.3(GNAI2): c.536G> A (p.Arg179His) single nucleotide variant Pathogenic rs137853227 GRCh37 Chromosome 3, 50293695: 50293695

Expression for Granulosa Cell Tumor of the Ovary

Search GEO for disease gene expression data for Granulosa Cell Tumor of the Ovary.

Pathways for Granulosa Cell Tumor of the Ovary

Pathways related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.8 ENO2 ERBB2 INS

GO Terms for Granulosa Cell Tumor of the Ovary

Cellular components related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome lumen GO:0031904 8.62 INS PRL

Biological processes related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 wound healing GO:0042060 9.5 ERBB2 INS TP53
2 cellular protein metabolic process GO:0044267 9.46 CP INS PRL SERPINA1
3 negative regulation of blood vessel diameter GO:0097756 9.26 CHGA INS
4 positive regulation of gene expression GO:0010628 9.02 ACTC1 ERBB2 INS TP53 VIM
5 positive regulation of follicle-stimulating hormone secretion GO:0046881 8.96 FOXL2 INHA

Molecular functions related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.33 INS SERPINA1 TP53
2 hormone activity GO:0005179 9.13 INHA INS PRL
3 identical protein binding GO:0042802 9.1 ERBB2 INS SERPINA1 SYP TP53 VIM

Sources for Granulosa Cell Tumor of the Ovary

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