GTCT
MCID: GRN022
MIFTS: 35

Granulosa Cell Tumor of the Ovary (GTCT) malady

Gastrointestinal, Cancer categories

Summaries for Granulosa Cell Tumor of the Ovary

Sources:
43NIH Rare Diseases, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:43 Granulosa cell tumor of the ovary is a rare type of ovarian cancer that accounts for approximately 2% of all ovarian tumors. this type of tumor is known as a sex cord-stromal tumor and usually occurs in adults. granulosa cell tumors of the ovary cause higher than normal levels of estrogen in a woman's body.  the symptoms of this excess estrogen depend on the woman's menstrual status; the most common symptoms include early puberty for affected young girls, an increase in abdomen size or irregularities of menstrual cycles in premenopausal women, and abnormal uterine bleeding in postmenopausal women. the exact cause of granulosa cell tumors is unknown.  treatment consists of surgery to remove the tumor, and additional treatments may also be used depending on the extent of the tumor. last updated: 11/14/2011

MalaCards: Granulosa Cell Tumor of the Ovary, also known as granulosa theca cell tumor of the ovary, is related to amenorrhea and sertoli-leydig cell tumor. An important gene associated with Granulosa Cell Tumor of the Ovary is FOXL2 (forkhead box L2), and among its related pathways are 14-3-3 Induced Apoptosis and Glioma. The compounds serine and tamoxifen have been mentioned in the context of this disorder. Affiliated tissues include ovary, and related mouse phenotypes are vision/eye and renal/urinary system.

Aliases & Classifications for Granulosa Cell Tumor of the Ovary

Sources:
43NIH Rare Diseases, 61UMLS
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Gastrointestinal


Aliases & Descriptions:

granulosa cell tumor of the ovary 43 61
granulosa theca cell tumor of the ovary 43
adult granulosa cell tumor of the ovary 43
gastrointestinal carcinoid tumor 61
granulosa theca cell tumor 43
gct of the ovary 43
gtct 43


Related Diseases for Granulosa Cell Tumor of the Ovary

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Granulosa Cell Tumor of the Ovary via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 261)
idRelated DiseaseScoreTop Affiliating Genes
1amenorrhea30.7INS, PRL
2sertoli-leydig cell tumor30.5KRT7
3hyperprolactinemia30.5PRL
4tuberous sclerosis30.5SYP, VIM
5sertoli cell tumor30.5VIM, SYP, ENO2
6somatostatinoma30.2CHGA
7carcinoid syndrome30.2CEACAM3, ENO2, ACTC1, CHGA, SYP
8hypercalcemia10.5
9pancytopenia10.4
10premature menopause10.4
11t cell deficiency10.4
12aromatase deficiency10.4
13gynandroblastoma10.4
14ovarian fibroma10.4
15granulosa cell malignant tumor10.4
16luteoma10.3
17bone giant cell tumor10.1
18chylous ascites10.1
19goblet cell carcinoid10.1
20pancreatic endocrine tumors10.1
21nasopharyngitis10.0TKTL1
22osteoarthritis10.0CFLAR
23amyotrophic lateral sclerosis10.0SYP
24arthritis10.0CFLAR
25multiple sclerosis10.0CFLAR
26dilated cardiomyopathy10.0ACTC1
27melanotic neuroectodermal tumor10.0SYP
28cystadenocarcinoma10.0CEACAM3
29phaeochromocytoma10.0CHGA
30deficiency anemia10.0CP
31fasciitis10.0ACTC1
32thymoma10.0CEACAM3
33pneumonia10.0SERPINA1
34cervical intraepithelial neoplasia10.0CFLAR
35premature ovarian failure10.0FOXL2
36psoriasis10.0SERPINA1
37dysembryoplastic neuroepithelial tumor10.0SYP
38wilson disease10.0CP
39hepatitis b10.0SERPINA1
40cerebral primitive neuroectodermal tumor10.0ENO2
41pneumoconiosis10.0CP
42anaplastic large cell lymphoma10.0ENO2
43herpes simplex10.0CFLAR
44neutropenia10.0CP
45hyperparathyroidism10.0CHGA
46mixed cell type cancer10.0KRT7
47nephrotic syndrome10.0SERPINA1
48bronchitis10.0SERPINA1
49multiple endocrine neoplasia10.0CHGA
50seminoma10.0ENO2

Graphical network of the top 20 diseases related to Granulosa Cell Tumor of the Ovary:



Diseases related to granulosa cell tumor of the ovary

Clinical Features for Granulosa Cell Tumor of the Ovary

Drugs & Therapeutics for Granulosa Cell Tumor of the Ovary

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Granulosa Cell Tumor of the Ovary

Drug clinical trials:

Search ClinicalTrials for Granulosa Cell Tumor of the Ovary

Search NIH Clinical Center for Granulosa Cell Tumor of the Ovary

Search CenterWatch for Granulosa Cell Tumor of the Ovary

Genetic Tests for Granulosa Cell Tumor of the Ovary

Anatomical Context for Granulosa Cell Tumor of the Ovary

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Granulosa Cell Tumor of the Ovary:

33
Ovary

Animal Models for Granulosa Cell Tumor of the Ovary or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Granulosa Cell Tumor of the Ovary

Genetic Variations for Granulosa Cell Tumor of the Ovary

Expression for genes affiliated with Granulosa Cell Tumor of the Ovary

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Granulosa Cell Tumor of the Ovary

Search GEO for disease gene expression data for Granulosa Cell Tumor of the Ovary.

Pathways for genes affiliated with Granulosa Cell Tumor of the Ovary

Sources:
52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 12EMD Millipore, 53R&D Systems
See all sources

Pathways related to Granulosa Cell Tumor of the Ovary according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
9.7TP53, BCL2
2
Hide members
9.6INS, TP53
39.6PKM, VEGFA, CP
4
Hide members
9.5TP53, CFLAR, BCL2
5
Apoptosis and survival Apoptotic TNF-family pathways
Hide members
9.4FAS, BCL2, TP53
6
Transcription P53 signaling pathway
Hide members
9.3BCL2, TP53, VEGFA
7
Apoptosis and survival Caspase cascade
Hide members
9.3CFLAR, BCL2, VIM, FAS
8
Hide members
9.2FAS, CFLAR, BCL2, TP53
99.1TP53, BCL2, VEGFA, FAS
10
Hide members
9.1VEGFA, BCL2, TP53, FAS
119.0TP53, VIM, VEGFA, BCL2
12
Hide members
8.9FAS, PRL, CFLAR, BCL2, TP53
138.6TP53, INS, VEGFA, PRL, BCL2
148.5ENO2, VEGFA, BCL2, INS

Compounds for genes affiliated with Granulosa Cell Tumor of the Ovary

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Granulosa Cell Tumor of the Ovary according to GeneCards/GeneDecks:

(show top 50)    (show all 125)
idCompoundScoreTop Affiliating Genes
1serine4510.2SYP, CFLAR, PKM
2tamoxifen45 50 29 1113.0CEACAM3, CHGA
3h2o2459.8SYP, VIM, CFLAR, CP
4tanshinone iia459.8BCL2, FAS, TP53
5streptozotocin459.7SYP, INS, CHGA
6reticulin459.6ACTC1, KRT7, SYP, VIM
7ly294002459.6CFLAR, VEGFA, BCL2
8noxa459.5TP53, BCL2, CFLAR, FAS
9smcc459.5SYP, CHGA, ENO2
10etoposide45 50 60 1112.5VIM, FAS, CHGA, CFLAR, BCL2
11depsipeptide459.5FAS, CFLAR, BCL2, TP53
12suberoylanilide hydroxamic acid459.4FAS, TP53, BCL2, CFLAR
13dutp459.4FAS, SYP, CFLAR, BCL2, TP53
14n-(4-hydroxyphenyl)retinamide459.3BCL2, TP53, CFLAR, VIM
15oxygen45 2410.3CEACAM3, SERPINA1, CHGA, FAS, CFLAR
16glycogen45 2410.2ACTC1, KRT7, INS, CHGA, SYP
17s 100459.2ACTC1, ENO2, VIM, CHGA, SYP
18oxaliplatin45 50 1111.1CFLAR, FAS, TP53, VEGFA
19mg 13245 6010.1FAS, TP53, BCL2, CFLAR, VEGFA
20mucicarmine459.0VIM, SYP, KRT7, ACTC1, CEACAM3
21octreotide45 60 29 1112.0CHGA, ENO2, INS, PRL
22paclitaxel45 50 1111.0FAS, TP53, BCL2, CFLAR, VEGFA, CHGA
235fluorouracil458.9BCL2, FAS, CFLAR, CEACAM3, TP53
24arsenite45 249.8BCL2, CFLAR, TP53, VEGFA, FAS
25b 723458.8SYP, ACTC1, CHGA, CEACAM3, KRT7, VIM
265-hydroxytryptamine458.8ENO2, SYP, PRL, VIM, CHGA
27adriamycin458.7TP53, CEACAM3, CFLAR, BCL2, VIM, FAS
28rapamycin458.7VIM, BCL2, CFLAR, VEGFA, INS, FAS
29carboplatin45 50 1110.6BCL2, TP53, ENO2, VEGFA, CHGA
30dexamethasone45 50 29 1111.6BCL2, ENO2, INS, VEGFA, FAS
31docetaxel45 50 60 1111.6CFLAR, ENO2, VEGFA, BCL2, TP53
32formaldehyde45 249.6ACTC1, ENO2, SYP, CHGA, VIM, KRT7
33actinomycin d458.5BCL2, TP53, CFLAR, VEGFA, FAS, VIM
34thymidylate458.5CEACAM3, BCL2, VEGFA, FAS, VIM, TP53
355-aza-2deoxycytidine458.4TP53, VIM, FAS, CFLAR, KRT7
36creatinine458.4CEACAM3, SERPINA1, ACTC1, INS, CHGA, SYP
37glucose458.3ACTC1, SERPINA1, TKTL1, CFLAR, KRT7, PKM
38doxorubicin45 50 1110.3BCL2, CEACAM3, CFLAR, TP53, VEGFA, VIM
39hematoxylin458.0CHGA, ENO2, CEACAM3, VIM, ACTC1, SYP
40acth458.0CEACAM3, ENO2, SERPINA1, INS, CHGA, SYP
41arginine458.0TP53, KRT7, INS, CHGA, PRL, CP
42cisplatin45 50 60 1111.0BCL2, FAS, SYP, CHGA, TP53, CFLAR
43lactate457.6INS, ENO2, CP, CHGA, CEACAM3, PKM
44lipid457.5CP, SERPINA1, VIM, SYP, CHGA, CFLAR
45retinoic acid45 248.1ENO2, ACTC1, KRT7, CFLAR, CHGA, TP53
46testosterone45 60 11 2410.1ACTC1, ENO2, CP, PRL, VIM, KRT7
47progesterone45 60 29 11 2410.7TP53, ENO2, SERPINA1, ACTC1, KRT7, CHGA
48tyrosine456.4VEGFA, INS, FAS, SYP, PKM, CEACAM3
49paraffin456.4VIM, CEACAM3, TP53, BCL2, ENO2, KRT7
50vegf456.1CP, CEACAM3, BCL2, ENO2, ACTC1, KRT7

GO Terms for genes affiliated with Granulosa Cell Tumor of the Ovary

Sources:
16Gene Ontology
See all sources

Cellular components related to Granulosa Cell Tumor of the Ovary according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1death-inducing signaling complexGO:03126410.0FAS, CFLAR
2secretory granuleGO:0301419.5VEGFA, PRL, CHGA
3extracellular vesicular exosomeGO:0700629.4PKM, ACTC1, VIM
4extracellular regionGO:0055768.3FAS, PRL, CHGA, VEGFA, INS, SERPINA1

Biological processes related to Granulosa Cell Tumor of the Ovary according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1renal system processGO:00301410.0BCL2, FAS
2regulation of transmembrane transporter activityGO:0228989.9BCL2, INS
3regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:20012399.9FAS, CFLAR
4B cell lineage commitmentGO:0023269.9TP53, BCL2
5ovarian follicle developmentGO:0015419.7FOXL2, VEGFA, BCL2
6regulation of mitochondrial membrane permeabilityGO:0469029.7TP53, BCL2
7neuron apoptotic processGO:0514029.6TP53, BCL2, FAS
8positive regulation of protein autophosphorylationGO:0319549.3INS, VEGFA
9positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.3VEGFA, INS, TP53
10negative regulation of apoptotic processGO:0430668.8TP53, BCL2, CFLAR, VEGFA, FAS

Molecular functions related to Granulosa Cell Tumor of the Ovary according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020208.5TP53, BCL2, SERPINA1, CFLAR, INS
2identical protein bindingGO:0428027.8VIM, FAS, SYP, VEGFA, INS, SERPINA1
3protein bindingGO:0055156.5CFLAR, TP53, BCL2, SERPINA1, VIM, FOXL2

Products for genes affiliated with Granulosa Cell Tumor of the Ovary

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Granulosa Cell Tumor of the Ovary

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet