MCID: GRN022
MIFTS: 37

Granulosa Cell Tumor of the Ovary

Categories: Rare diseases

Aliases & Classifications for Granulosa Cell Tumor of the Ovary

MalaCards integrated aliases for Granulosa Cell Tumor of the Ovary:

Name: Granulosa Cell Tumor of the Ovary 50 69
Adult Granulosa Cell Tumor of the Ovary 50
Granulosa Theca Cell Tumor of the Ovary 50
Granulosa Theca Cell Tumor 50
Gct of the Ovary 50
Gtct 50

Classifications:



Summaries for Granulosa Cell Tumor of the Ovary

NIH Rare Diseases : 50 granulosa celltumor of the ovary is a rare type of ovarian cancer that accounts for approximately 2% of all ovarian tumors. this type of tumor is known as a sex cord-stromal tumor and usually occurs in adults. granulosa cell tumors of the ovary cause higher than normal levels of estrogen in a woman's body.  the symptoms of this excess estrogen depend on the woman's menstrual status; the most common symptoms include early puberty for affected young girls, an increase in abdomen size or irregularities of menstrual cycles in premenopausal women, and abnormal uterine bleeding in postmenopausal women. the exact cause of granulosa cell tumors is unknown.  treatment consists of surgery to remove the tumor, and additional treatments may also be used depending on the extent of the tumor. last updated: 1/7/2016

MalaCards based summary : Granulosa Cell Tumor of the Ovary, also known as adult granulosa cell tumor of the ovary, is related to lymphocytic hypophysitis and gastric signet ring cell adenocarcinoma. An important gene associated with Granulosa Cell Tumor of the Ovary is GNAI2 (G Protein Subunit Alpha I2), and among its related pathways/superpathways is HIF-1 signaling pathway. The drugs Paclitaxel and Bleomycin have been mentioned in the context of this disorder. Affiliated tissues include ovary, endothelial and breast, and related phenotypes are behavior/neurological and cardiovascular system

Related Diseases for Granulosa Cell Tumor of the Ovary

Diseases related to Granulosa Cell Tumor of the Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 252)
id Related Disease Score Top Affiliating Genes
1 lymphocytic hypophysitis 10.9 ACTC1 VIM
2 gastric signet ring cell adenocarcinoma 10.9 ACTC1 VIM
3 aortic aneurysm 10.9 ACTC1 VIM
4 iridogoniodysgenesis and skeletal anomalies 10.9 ACTC1 VIM
5 congenital disorder of glycosylation, type if 10.9 ERBB2 TP53
6 esophagus leiomyosarcoma 10.9 ACTC1 VIM
7 benallegue lacete syndrome 10.8 ENO2 VIM
8 intellectual disability-polydactyly-uncombable hair syndrome 10.8 ENO2 VIM
9 endocervicitis 10.8 ERBB2 TP53
10 spleen angiosarcoma 10.8 ACTC1 VIM
11 skin lipoma 10.8 ACTC1 VIM
12 hemangioma of liver 10.8 ACTC1 TP53
13 laryngeal neuroendocrine tumor 10.8 ACTC1 VIM
14 leiomyoma cutis 10.8 ACTC1 TP53
15 uniparental disomy of chromosome 11 10.8 ACTC1 VIM
16 pineal region yolk sac tumor 10.8 ENO2 VIM
17 breast malignant phyllodes tumor 10.8 ERBB2 SYP
18 early invasive cervical adenocarcinoma 10.8 ENO2 SERPINA1
19 skin sarcoma 10.8 ERBB2 PRL
20 animal phobia 10.8 ERBB2 TP53
21 paranasal sinus cancer 10.8 ENO2 SYP
22 testicular malignant germ cell cancer 10.7 ENO2 PRL
23 glomus tumor 10.7 ENO2 SYP
24 extracranial neuroblastoma 10.7 ERBB2 TP53
25 bronchus adenoma 10.7 ENO2 SYP
26 pemphigus foliaceus 10.7 ENO2 SYP
27 gallbladder adenocarcinoma 10.7 ENO2 SYP
28 aggressive systemic mastocytosis 10.7 TP53 VIM
29 chondroid chordoma 10.7 ENO2 SYP
30 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 10.7 SYP TP53
31 supratentorial primitive neuroectodermal tumor 10.7 CHGA ENO2
32 adult medulloblastoma 10.7 SYP VIM
33 pulmonary venoocclusive disease 10.7 ACTC1 TP53 VIM
34 water-clear cell adenoma 10.7 PRL TP53
35 myoma 10.7 ACTC1 ENO2 VIM
36 myxoid leiomyosarcoma 10.7 ACTC1 ENO2 VIM
37 cystic kidney disease 10.7 ENO2 ERBB2 TP53
38 cervical keratinizing squamous cell carcinoma 10.7 ENO2 INS
39 ossifying fibromyxoid tumor 10.6 ENO2 TP53 VIM
40 intraductal breast myoepitheliosis 10.6 CHGA TP53
41 cauda equina intradural extramedullary astrocytoma 10.6 ENO2 SYP
42 malignant ovarian mixed epithelial neoplasm 10.6 CHGA SYP
43 pyoderma 10.6 CHGA VIM
44 neutrophil immunodeficiency syndrome 10.6 ACTC1 TP53 VIM
45 mixed extragonadal germ cell cancer 10.6 ACTC1 TP53 VIM
46 spinal cord ependymoma 10.6 CHGA SYP
47 hyperpituitarism 10.6 ACTC1 ENO2 VIM
48 olfactory nerve neoplasm 10.6 PRL SYP
49 enteric pattern testicular yolk sac tumor 10.6 CHGA ENO2
50 pleural empyema 10.6 SYP TP53

Graphical network of the top 20 diseases related to Granulosa Cell Tumor of the Ovary:



Diseases related to Granulosa Cell Tumor of the Ovary

Symptoms & Phenotypes for Granulosa Cell Tumor of the Ovary

MGI Mouse Phenotypes related to Granulosa Cell Tumor of the Ovary:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.97 PRL SYP CP ENO2 TP53 ERBB2
2 cardiovascular system MP:0005385 9.91 CP TP53 ERBB2 VIM GNAI2 INHA
3 cellular MP:0005384 9.81 CP ENO2 TP53 ERBB2 VIM GNAI2
4 homeostasis/metabolism MP:0005376 9.7 PRL CHGA CP TP53 ERBB2 VIM
5 nervous system MP:0003631 9.28 PRL SYP CP ENO2 TP53 ERBB2

Drugs & Therapeutics for Granulosa Cell Tumor of the Ovary

Drugs for Granulosa Cell Tumor of the Ovary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Bleomycin Approved Phase 2 11056-06-7 5360373
3
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
4
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
5
Etoposide Approved Phase 2 33419-42-0 36462
6
Temozolomide Approved, Investigational Phase 1, Phase 2 85622-93-1 5394
7
nivolumab Approved Phase 2 946414-94-4
8
Bevacizumab Approved, Investigational Phase 2 216974-75-3
9
Ketoconazole Approved, Investigational Phase 2 65277-42-1 47576 3823
10
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
11 Albumin-Bound Paclitaxel Phase 2
12 Antimitotic Agents Phase 2
13 Antineoplastic Agents, Phytogenic Phase 2
14 Anti-Bacterial Agents Phase 2
15 Antibiotics, Antitubercular Phase 2
16 Etoposide phosphate Phase 2
17 Topoisomerase Inhibitors Phase 2
18 Alkylating Agents Phase 1, Phase 2
19 Antibodies Phase 2
20 Antibodies, Monoclonal Phase 2
21 Immunoglobulins Phase 2
22 Angiogenesis Inhibitors Phase 2
23 Angiogenesis Modulating Agents Phase 2
24 Endothelial Growth Factors Phase 2
25 Mitogens Phase 2
26 Antifungal Agents Phase 2
27 Anti-Infective Agents Phase 2
28 Cytochrome P-450 CYP3A Inhibitors Phase 2
29 Cytochrome P-450 Enzyme Inhibitors Phase 2
30 Hormone Antagonists Phase 2
31 Hormones Phase 2
32 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
33 Steroid Synthesis Inhibitors Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Paclitaxel in Treating Patients With Ovarian Stromal Cancer Completed NCT00006227 Phase 2 Paclitaxel
2 Paclitaxel and Carboplatin or Bleomycin Sulfate, Etoposide Phosphate, and Cisplatin in Treating Patients With Advanced or Recurrent Sex Cord-Ovarian Stromal Tumors Recruiting NCT01042522 Phase 2 Carboplatin;Cisplatin;Etoposide Phosphate;Paclitaxel
3 TRC102 and Temozolomide for Relapsed Solid Tumors and Lymphomas Recruiting NCT01851369 Phase 1, Phase 2 TRC 102
4 A Phase II Trial of Ipilimumab and Nivolumab for the Treatment of Rare Cancers Recruiting NCT02923934 Phase 2 Ipilimumab;Nivolumab
5 Bevacizumab in Treating Patients With Recurrent Sex Cord-Stromal Tumors of the Ovary Active, not recruiting NCT00748657 Phase 2
6 Ketoconazole as Inhibitor of the Enzyme CYP17 in Locally Advanced or Disseminated Granulosa Cell Tumour of Ovary Terminated NCT01584297 Phase 2 Ketoconazole
7 Orteronel (TAK-700) in Metastatic or Advanced Non-resectable Granulosa Cell Ovarian Tumors. The Greko II Study. Terminated NCT02101684 Phase 2 Orteronel 300mg BID

Search NIH Clinical Center for Granulosa Cell Tumor of the Ovary

Genetic Tests for Granulosa Cell Tumor of the Ovary

Anatomical Context for Granulosa Cell Tumor of the Ovary

MalaCards organs/tissues related to Granulosa Cell Tumor of the Ovary:

39
Ovary, Endothelial, Breast, Adrenal Gland, Liver, Lung, Bone

Publications for Granulosa Cell Tumor of the Ovary

Articles related to Granulosa Cell Tumor of the Ovary:

(show top 50) (show all 154)
id Title Authors Year
1
Juvenile Granulosa Cell Tumor of the Ovary: A Clinicopathologic Study. ( 27702598 )
2017
2
Clinical and genetic analysis of recurrent adult-type granulosa cell tumor of the ovary: Persistent preservation of heterozygous c.402C>G FOXL2 mutation. ( 28594898 )
2017
3
Postmenopausal mild hirsutism and hyperandrogenemia due to granulosa cell tumor of the ovary: a case report. ( 28851436 )
2017
4
Pathogenesis and treatment of adult-type granulosa cell tumor of the ovary. ( 28276867 )
2017
5
Stromal p16 Overexpression in Adult Granulosa Cell Tumors of the Ovary. ( 28476811 )
2017
6
Aggressive Granulosa Cell Tumor of the Ovary with Rapid Recurrence: a Case Report and Review of the Literature. ( 27323838 )
2016
7
Prognostic factors for recurrence in early stage adult granulosa cell tumor of the ovary. ( 27324782 )
2016
8
Cytomorphology and Clinicopathologic Correlation of the Recurrent and Metastatic Adult Granulosa Cell Tumor of the Ovary: A Retrospective Review. ( 27493080 )
2016
9
Fine needle aspiration cytology of cystic primary adult granulosa cell tumor of the ovary: Potential diagnostic pitfalls with other cystic ovarian lesions. ( 26956549 )
2016
10
Molecularly Defined Adult Granulosa Cell Tumor of the Ovary: The Clinical Phenotype. ( 27297428 )
2016
11
Granulosa cell tumor of the ovary. ( 28757730 )
2016
12
Metastasis of the liver with a granulosa cell tumor of the ovary: A case report. ( 25621056 )
2015
13
A recurrent granulosa cell tumor of the ovary 25 years after the initial diagnosis: A case report. ( 25979613 )
2015
14
Recurrence of adult granulosa cell tumor of the ovary: experience at a tertiary care center. ( 24630126 )
2014
15
Adult granulosa cell tumor of the ovary: a retrospective study of 37 cases. ( 25556264 )
2014
16
Parameters for predicting granulosa cell tumor of the ovary: a single center retrospective comparative study. ( 25339044 )
2014
17
Fertility-sparing surgery for advanced juvenile granulosa cell tumor of the ovary. ( 24656706 )
2014
18
Aromatase Inhibitor Therapy As Effective Rescue in a Patient With Tamoxifen-Refractory Metastatic Granulosa Cell Tumor of the Ovary. ( 24934781 )
2014
19
Granulosa cell tumor of the ovary--an incidental finding during caesarean section--a rare case report. ( 25219997 )
2014
20
Letrozole efficacy in the treatment of granulosa cell tumor of the ovary: a case report. ( 24051926 )
2013
21
The incidence of endometrial hyperplasia and cancer in 1031 patients with a granulosa cell tumor of the ovary: long-term follow-up in a population-based cohort study. ( 24257556 )
2013
22
Granulosa cell tumor of the ovary with high FDG uptake. ( 23640219 )
2013
23
Successful treatment of adult-type granulosa cell tumor of the ovary by palliative radiotherapy. ( 22175649 )
2012
24
Ruptured granulosa cell tumor of the ovary as a cause of acute abdomen in postmenopausal woman. ( 22973526 )
2012
25
Primary amenorrhea due to juvenile granulosa-cell tumor of the ovary: a case report. ( 22353374 )
2012
26
Management of peritoneal dissemination of recurrences granulosa cell tumor of the ovary. ( 23268102 )
2012
27
Granulosa cell tumor of the ovary after long-term use of tamoxifen and toremifene. ( 22612286 )
2012
28
A case of granulosa cell tumor of the ovary detected from metastatic foci. ( 23327064 )
2012
29
Delayed menopause due to granulosa cell tumor of the ovary. ( 22408338 )
2011
30
Prolonged survival following maximal cytoreductive effort for peritoneal metastases from recurrent granulosa cell tumor of the ovary. ( 21998767 )
2011
31
FOXL2 mutation and large-scale genomic imbalances in adult granulosa cell tumors of the ovary. ( 22200085 )
2011
32
Role of adjuvant radiotherapy in granulosa cell tumors of the ovary. ( 20472362 )
2011
33
Granulosa cell tumor of the ovary: time to launch a new prospective trial. ( 21998755 )
2011
34
Synchronous adult-type granulosa cell tumor of the ovary with ovarian fibroma: a case report. ( 22335040 )
2011
35
Prognostic significance of FOXL2 mutation and mRNA expression in adult and juvenile granulosa cell tumors of the ovary. ( 21623383 )
2011
36
Medico-legal observations concerning a mortal case of granulosa cell tumor of the ovary in an 8-month-old infant. ( 21843743 )
2011
37
Granulosa cell tumor of the ovary and antecedent of adjuvant tamoxifen use for breast cancer. ( 20704728 )
2010
38
Unusual virilization in girls with juvenile granulosa cell tumors of the ovary is related to intratumoral aromatase deficiency. ( 20395670 )
2010
39
Granulosa cell tumor of the ovary: cytologic findings. ( 20715655 )
2010
40
Neoadjuvant bevacizumab in a granulosa cell tumor of the ovary: a case report. ( 21115938 )
2010
41
Late recurrence of granulosa cell tumor of the ovary with synchronous gastric signet-ring cell carcinoma. ( 21229651 )
2010
42
Nearly 30 Years of Treatment for Recurrent Granulosa Cell Tumor of the Ovary: A Case Report and Review of the Literature. ( 20740152 )
2010
43
Granulosa cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 21 cases. ( 20349790 )
2010
44
The FOXL2 C134W mutation is characteristic of adult granulosa cell tumors of the ovary. ( 20693978 )
2010
45
Unusual presentation of granulosa cell tumor of the ovary. ( 20713871 )
2010
46
Fine needle aspiration of metastatic adult granulosa cell tumor of the ovary: a case report. ( 21053572 )
2010
47
Prognostic factors in adult granulosa cell tumor of the ovary. ( 19198715 )
2009
48
An Unusual Case of Juvenile Granulosa Cell Tumor of the Ovary. ( 27843515 )
2009
49
The new molecular biology of granulosa cell tumors of the ovary. ( 19725933 )
2009
50
Isolated breast metastasis from granulosa cell tumor of the ovary. ( 19306013 )
2009

Variations for Granulosa Cell Tumor of the Ovary

ClinVar genetic disease variations for Granulosa Cell Tumor of the Ovary:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 GNAI2 NM_002070.3(GNAI2): c.535C> T (p.Arg179Cys) single nucleotide variant Pathogenic rs137853226 GRCh37 Chromosome 3, 50293694: 50293694
2 GNAI2 NM_002070.3(GNAI2): c.536G> A (p.Arg179His) single nucleotide variant Pathogenic rs137853227 GRCh37 Chromosome 3, 50293695: 50293695

Expression for Granulosa Cell Tumor of the Ovary

Search GEO for disease gene expression data for Granulosa Cell Tumor of the Ovary.

Pathways for Granulosa Cell Tumor of the Ovary

Pathways related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.79 ENO2 ERBB2 INS

GO Terms for Granulosa Cell Tumor of the Ovary

Cellular components related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 ACTC1 CHGA CP ENO2 INHA INS
2 endosome lumen GO:0031904 8.96 INS PRL

Biological processes related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.26 CP INS PRL SERPINA1
2 positive regulation of gene expression GO:0010628 9.02 ACTC1 ERBB2 INS TP53 VIM

Molecular functions related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.33 INHA INS PRL
2 protease binding GO:0002020 9.13 INS SERPINA1 TP53
3 identical protein binding GO:0042802 9.1 ERBB2 INS SERPINA1 SYP TP53 VIM

Sources for Granulosa Cell Tumor of the Ovary

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