GTCT
MCID: GRN022
MIFTS: 38

Granulosa Cell Tumor of the Ovary (GTCT) malady

Categories: Rare diseases

Aliases & Classifications for Granulosa Cell Tumor of the Ovary

Aliases & Descriptions for Granulosa Cell Tumor of the Ovary:

Name: Granulosa Cell Tumor of the Ovary 50 69
Adult Granulosa Cell Tumor of the Ovary 50
Granulosa Theca Cell Tumor of the Ovary 50
Granulosa Theca Cell Tumor 50
Gct of the Ovary 50
Gtct 50

Classifications:



Summaries for Granulosa Cell Tumor of the Ovary

NIH Rare Diseases : 50 granulosa cell tumor of the ovary is a rare type of ovarian cancer that accounts for approximately 2% of all ovarian tumors. this type of tumor is known as a sex cord-stromal tumor and usually occurs in adults. granulosa cell tumors of the ovary cause higher than normal levels of estrogen in a woman's body.  the symptoms of this excess estrogen depend on the woman's menstrual status; the most common symptoms include early puberty for affected young girls, an increase in abdomen size or irregularities of menstrual cycles in premenopausal women, and abnormal uterine bleeding in postmenopausal women. the exact cause of granulosa cell tumors is unknown.  treatment consists of surgery to remove the tumor, and additional treatments may also be used depending on the extent of the tumor. last updated: 1/7/2016

MalaCards based summary : Granulosa Cell Tumor of the Ovary, also known as adult granulosa cell tumor of the ovary, is related to lymphomatoid papulosis and chest wall parachordoma. An important gene associated with Granulosa Cell Tumor of the Ovary is VIM (Vimentin), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and HIF-1 signaling pathway. The drugs Paclitaxel and Bleomycin have been mentioned in the context of this disorder. Affiliated tissues include ovary, breast and lung, and related phenotypes are cardiovascular system and homeostasis/metabolism

Related Diseases for Granulosa Cell Tumor of the Ovary

Diseases related to Granulosa Cell Tumor of the Ovary via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 197)
id Related Disease Score Top Affiliating Genes
1 lymphomatoid papulosis 10.4 ACTC1 VIM
2 chest wall parachordoma 10.3 ACTC1 VIM
3 pericardium leiomyoma 10.3 ACTC1 TP53
4 isolated anterior cervical hypertrichosis 10.3 ACTC1 VIM
5 breast sarcoma 10.3 ERBB2 SYP
6 cystinosis, nephropathic 10.3 ERBB2 TP53
7 osteomyelitis 10.3 ACTC1 VIM
8 myoma 10.3 ACTC1 VIM
9 lung clear cell-sugar-tumor 10.3 ERBB2 TP53
10 congenital myasthenic syndrome 10.3 ACTC1 VIM
11 conjunctival cancer 10.3 ACTC1 TP53 VIM
12 spleen angiosarcoma 10.3 ACTC1 VIM
13 coronary stenosis 10.3 ACTC1 TP53 VIM
14 skin sarcoma 10.3 ERBB2 PRL
15 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 10.3 ACTC1 SYP VIM
16 sebaceous adenoma 10.2 ACTC1 SYP VIM
17 benign schwannoma 10.2 ENO2 VIM
18 urethral cancer 10.2 ACTC1 VIM
19 neutrophil immunodeficiency syndrome 10.2 ACTC1 TP53 VIM
20 male reproductive organ benign neoplasm 10.2 ERBB2 PRL TP53
21 central nervous system primitive neuroectodermal neoplasm 10.2 ERBB2 PRL TP53
22 lung benign neoplasm 10.2 ACTC1 SYP VIM
23 cecum adenoma 10.2 ACTC1 TP53 VIM
24 cervical benign neoplasm 10.2 SYP TP53
25 myxopapillary ependymoma 10.2 SYP VIM
26 infiltrating renal pelvis transitional cell carcinoma 10.2 ENO2 SYP
27 arthus reaction 10.2 ERBB2 SYP TP53
28 scirrhous adenocarcinoma 10.2 ACTC1 SYP VIM
29 bone benign neoplasm 10.2 PRL SYP TP53
30 peroneal nerve paralysis 10.2 CHGA SYP
31 vulva adenocarcinoma 10.2 ERBB2 SYP TP53
32 appendicitis 10.2 ENO2 SERPINA1
33 necrobiosis lipoidica 10.2 ERBB2 PRL TP53
34 hepatitis 10.2
35 diencephalic neoplasm 10.2 INS PRL TP53
36 brain stem ependymoma 10.2 CHGA SYP
37 glomus tumor 10.2 ENO2 SYP
38 malignant dermis tumor 10.2 ACTC1 ENO2 VIM
39 ossifying fibromyxoid tumor 10.2 ENO2 TP53 VIM
40 synovitis 10.2 KRT7 SYP
41 bladder colloid adenocarcinoma 10.2 ENO2 ERBB2 TP53
42 epithelioid malignant peripheral nerve sheath tumor 10.2 CHGA SYP
43 primary hyperoxaluria 10.2 ENO2 ERBB2 TP53
44 autosomal recessive stickler syndrome 10.2 ENO2 SYP VIM
45 nephrogenic adenoma of urinary bladder 10.2 ENO2 SYP VIM
46 pemphigus foliaceus 10.2 ENO2 SYP
47 biemond syndrome 10.2 ACTC1 KRT7 VIM
48 hyperpituitarism 10.2 ACTC1 ENO2 VIM
49 blood group incompatibility 10.2 ENO2 SYP TP53
50 familial glucocorticoid deficiency 10.2 ERBB2 PRL TP53

Graphical network of the top 20 diseases related to Granulosa Cell Tumor of the Ovary:



Diseases related to Granulosa Cell Tumor of the Ovary

Symptoms & Phenotypes for Granulosa Cell Tumor of the Ovary

MGI Mouse Phenotypes related to Granulosa Cell Tumor of the Ovary:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.56 TP53 VIM ACTC1 CHGA CP ERBB2
2 homeostasis/metabolism MP:0005376 9.32 ACTC1 CHGA CP ERBB2 INHA INS

Drugs & Therapeutics for Granulosa Cell Tumor of the Ovary

Drugs for Granulosa Cell Tumor of the Ovary (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 55)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Bleomycin Approved Phase 2 11056-06-7 5360373
3
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
4
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
5
Etoposide Approved Phase 2 33419-42-0 36462
6
Succinylcholine Approved Phase 2 306-40-1 5314
7
Bevacizumab Approved, Investigational Phase 2 216974-75-3
8
nivolumab Approved Phase 2 946414-94-4
9
Ketoconazole Approved, Investigational Phase 2 65277-42-1 47576 3823
10
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
11 Albumin-Bound Paclitaxel Phase 2
12 Antimitotic Agents Phase 2
13 Antineoplastic Agents, Phytogenic Phase 2
14 Anti-Bacterial Agents Phase 2,Phase 1
15 Antibiotics, Antitubercular Phase 2,Phase 1
16 Topoisomerase Inhibitors Phase 2,Phase 1
17 Hormone Antagonists Phase 2
18 Hormones Phase 2
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
20 Steroid Synthesis Inhibitors Phase 2
21 Etoposide phosphate Phase 2
22 Neuromuscular Agents Phase 2
23 Neuromuscular Blocking Agents Phase 2
24 Neuromuscular Depolarizing Agents Phase 2
25 Peripheral Nervous System Agents Phase 2
26 Angiogenesis Inhibitors Phase 2
27 Angiogenesis Modulating Agents Phase 2
28 Antibodies Phase 2
29 Antibodies, Monoclonal Phase 2
30 Endothelial Growth Factors Phase 2
31 Immunoglobulin G Phase 2
32 Immunoglobulins Phase 2
33 Mitogens Phase 2
34 Antifungal Agents Phase 2
35 Anti-Infective Agents Phase 2
36 Cytochrome P-450 CYP3A Inhibitors Phase 2
37 Cytochrome P-450 Enzyme Inhibitors Phase 2
38
Doxorubicin Approved, Investigational Phase 1 23214-92-8 31703
39
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
40
Doxil Approved June 1999 Phase 1 31703
41 Liver Extracts Phase 1
42 Alkylating Agents Phase 1
43 Antineoplastic Agents, Alkylating Phase 1
44
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757 53477783
45
Progesterone Approved, Vet_approved 57-83-0 5994
46
Letrozole Approved, Investigational 112809-51-5 3902
47
Leuprolide Approved, Investigational 53714-56-0 3911 657181
48 Estradiol 17 beta-cypionate
49 Estradiol 3-benzoate
50 Estradiol valerate 979-32-8

Interventional clinical trials:

(show all 12)
id Name Status NCT ID Phase
1 Paclitaxel in Treating Patients With Ovarian Stromal Cancer Completed NCT00006227 Phase 2
2 Paclitaxel and Carboplatin or Bleomycin Sulfate, Etoposide Phosphate, and Cisplatin in Treating Patients With Advanced or Recurrent Sex Cord-Ovarian Stromal Tumors Recruiting NCT01042522 Phase 2
3 Bevacizumab in Treating Patients With Recurrent Sex Cord-Stromal Tumors of the Ovary Active, not recruiting NCT00748657 Phase 2
4 A Phase II Trial of Ipilimumab and Nivolumab for the Treatment of Rare Cancers Not yet recruiting NCT02923934 Phase 2
5 Ketoconazole as Inhibitor of the Enzyme CYP17 in Locally Advanced or Disseminated Granulosa Cell Tumour of Ovary Terminated NCT01584297 Phase 2
6 Orteronel (TAK-700) in Metastatic or Advanced Non-resectable Granulosa Cell Ovarian Tumors. The Greko II Study. Terminated NCT02101684 Phase 2
7 Effects of STM 434 Alone or in Combination With Liposomal Doxorubicin in Patients With Ovarian Cancer or Other Advanced Solid Tumors Completed NCT02262455 Phase 1
8 TRC102 and Temozolomide for Relapsed Solid Tumors and Lymphomas Recruiting NCT01851369 Phase 1
9 Gene-polymorphisms Relating to Human Subfertility Completed NCT01385618
10 Effect of Increased Circulating Androgens on Granulosa Cell Responses to FSH. Completed NCT02389088
11 International Ovarian & Testicular Stromal Tumor Registry Recruiting NCT01970696
12 The Use Of AMH for the Discrimination of Polycystic and Multicystic Ovaries in Nonhyperandrogenic Patients Active, not recruiting NCT01878955

Search NIH Clinical Center for Granulosa Cell Tumor of the Ovary

Genetic Tests for Granulosa Cell Tumor of the Ovary

Anatomical Context for Granulosa Cell Tumor of the Ovary

MalaCards organs/tissues related to Granulosa Cell Tumor of the Ovary:

39
Ovary, Breast, Lung, Bone, Liver, Adrenal Gland

Publications for Granulosa Cell Tumor of the Ovary

Articles related to Granulosa Cell Tumor of the Ovary:

(show top 50) (show all 148)
id Title Authors Year
1
Juvenile Granulosa Cell Tumor of the Ovary: A Clinicopathologic Study. ( 27702598 )
2017
2
Aggressive Granulosa Cell Tumor of the Ovary with Rapid Recurrence: a Case Report and Review of the Literature. ( 27323838 )
2016
3
Fine needle aspiration cytology of cystic primary adult granulosa cell tumor of the ovary: Potential diagnostic pitfalls with other cystic ovarian lesions. ( 26956549 )
2016
4
Molecularly Defined Adult Granulosa Cell Tumor of the Ovary: The Clinical Phenotype. ( 27297428 )
2016
5
Cytomorphology and Clinicopathologic Correlation of the Recurrent and Metastatic Adult Granulosa Cell Tumor of the Ovary: A Retrospective Review. ( 27493080 )
2016
6
Prognostic factors for recurrence in early stage adult granulosa cell tumor of the ovary. ( 27324782 )
2016
7
A recurrent granulosa cell tumor of the ovary 25 years after the initial diagnosis: A case report. ( 25979613 )
2015
8
Metastasis of the liver with a granulosa cell tumor of the ovary: A case report. ( 25621056 )
2015
9
Granulosa cell tumor of the ovary--an incidental finding during caesarean section--a rare case report. ( 25219997 )
2014
10
Adult granulosa cell tumor of the ovary: a retrospective study of 37 cases. ( 25556264 )
2014
11
Aromatase Inhibitor Therapy As Effective Rescue in a Patient With Tamoxifen-Refractory Metastatic Granulosa Cell Tumor of the Ovary. ( 24934781 )
2014
12
Fertility-sparing surgery for advanced juvenile granulosa cell tumor of the ovary. ( 24656706 )
2014
13
Recurrence of adult granulosa cell tumor of the ovary: experience at a tertiary care center. ( 24630126 )
2014
14
Parameters for predicting granulosa cell tumor of the ovary: a single center retrospective comparative study. ( 25339044 )
2014
15
Letrozole efficacy in the treatment of granulosa cell tumor of the ovary: a case report. ( 24051926 )
2013
16
Granulosa cell tumor of the ovary with high FDG uptake. ( 23640219 )
2013
17
The incidence of endometrial hyperplasia and cancer in 1031 patients with a granulosa cell tumor of the ovary: long-term follow-up in a population-based cohort study. ( 24257556 )
2013
18
Management of peritoneal dissemination of recurrences granulosa cell tumor of the ovary. ( 23268102 )
2012
19
Ruptured granulosa cell tumor of the ovary as a cause of acute abdomen in postmenopausal woman. ( 22973526 )
2012
20
Granulosa cell tumor of the ovary after long-term use of tamoxifen and toremifene. ( 22612286 )
2012
21
Successful treatment of adult-type granulosa cell tumor of the ovary by palliative radiotherapy. ( 22175649 )
2012
22
A case of granulosa cell tumor of the ovary detected from metastatic foci. ( 23327064 )
2012
23
Primary amenorrhea due to juvenile granulosa-cell tumor of the ovary: a case report. ( 22353374 )
2012
24
Synchronous adult-type granulosa cell tumor of the ovary with ovarian fibroma: a case report. ( 22335040 )
2011
25
FOXL2 mutation and large-scale genomic imbalances in adult granulosa cell tumors of the ovary. ( 22200085 )
2011
26
Prognostic significance of FOXL2 mutation and mRNA expression in adult and juvenile granulosa cell tumors of the ovary. ( 21623383 )
2011
27
Delayed menopause due to granulosa cell tumor of the ovary. ( 22408338 )
2011
28
Medico-legal observations concerning a mortal case of granulosa cell tumor of the ovary in an 8-month-old infant. ( 21843743 )
2011
29
Granulosa cell tumor of the ovary: time to launch a new prospective trial. ( 21998755 )
2011
30
Prolonged survival following maximal cytoreductive effort for peritoneal metastases from recurrent granulosa cell tumor of the ovary. ( 21998767 )
2011
31
Granulosa cell tumor of the ovary and antecedent of adjuvant tamoxifen use for breast cancer. ( 20704728 )
2010
32
Unusual presentation of granulosa cell tumor of the ovary. ( 20713871 )
2010
33
Fine needle aspiration of metastatic adult granulosa cell tumor of the ovary: a case report. ( 21053572 )
2010
34
Late recurrence of granulosa cell tumor of the ovary with synchronous gastric signet-ring cell carcinoma. ( 21229651 )
2010
35
The FOXL2 C134W mutation is characteristic of adult granulosa cell tumors of the ovary. ( 20693978 )
2010
36
Neoadjuvant bevacizumab in a granulosa cell tumor of the ovary: a case report. ( 21115938 )
2010
37
Unusual virilization in girls with juvenile granulosa cell tumors of the ovary is related to intratumoral aromatase deficiency. ( 20395670 )
2010
38
Granulosa cell tumors of the ovary: a clinicopathologic and immunohistochemical study of 21 cases. ( 20349790 )
2010
39
Granulosa cell tumor of the ovary: cytologic findings. ( 20715655 )
2010
40
Nearly 30 Years of Treatment for Recurrent Granulosa Cell Tumor of the Ovary: A Case Report and Review of the Literature. ( 20740152 )
2010
41
Isolated breast metastasis from granulosa cell tumor of the ovary. ( 19306013 )
2009
42
Juvenile granulosa cell tumor of the ovary presenting with pleural effusion and ascites. ( 19225930 )
2009
43
The new molecular biology of granulosa cell tumors of the ovary. ( 19725933 )
2009
44
Mutation of FOXL2 in granulosa-cell tumors of the ovary. ( 19516027 )
2009
45
Prognostic factors in adult granulosa cell tumor of the ovary. ( 19198715 )
2009
46
An Unusual Case of Juvenile Granulosa Cell Tumor of the Ovary. ( 27843515 )
2009
47
Granulosa cell tumor of the ovary: tumor review. ( 18815151 )
2008
48
Recurrent juvenile granulosa cell tumor of the ovary managed by palliative radiotherapy. ( 18028383 )
2008
49
Cystic fluid and fine needle aspiration cytopathology of cystic adult granulosa cell tumor of the ovary: a case report. ( 18500005 )
2008
50
Glucose metabolism and angiogenesis in granulosa cell tumors of the ovary: activation of Akt, expression of M2PK, TKTL1 and VEGF. ( 18394773 )
2008

Variations for Granulosa Cell Tumor of the Ovary

ClinVar genetic disease variations for Granulosa Cell Tumor of the Ovary:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 GNAI2 NM_002070.3(GNAI2): c.535C> T (p.Arg179Cys) single nucleotide variant Pathogenic rs137853226 GRCh37 Chromosome 3, 50293694: 50293694
2 GNAI2 NM_002070.3(GNAI2): c.536G> A (p.Arg179His) single nucleotide variant Pathogenic rs137853227 GRCh37 Chromosome 3, 50293695: 50293695

Expression for Granulosa Cell Tumor of the Ovary

Search GEO for disease gene expression data for Granulosa Cell Tumor of the Ovary.

Pathways for Granulosa Cell Tumor of the Ovary

Pathways related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.26 INS SERPINA1 VIM
2 10.79 ENO2 ERBB2 INS

GO Terms for Granulosa Cell Tumor of the Ovary

Cellular components related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 ACTC1 CHGA CP ENO2 INHA INS
2 endosome lumen GO:0031904 8.96 INS PRL

Biological processes related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.26 CP INS PRL SERPINA1
2 negative regulation of vasodilation GO:0045908 9.16 CHGA INS
3 positive regulation of gene expression GO:0010628 9.02 ACTC1 ERBB2 INS TP53 VIM

Molecular functions related to Granulosa Cell Tumor of the Ovary according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.33 INHA INS PRL
2 protease binding GO:0002020 9.13 INS SERPINA1 TP53
3 identical protein binding GO:0042802 9.1 ERBB2 INS SERPINA1 SYP TP53 VIM

Sources for Granulosa Cell Tumor of the Ovary

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