GTCT
MCID: GRN022
MIFTS: 43

Granulosa Cell Tumor of the Ovary (GTCT) malady

Rare diseases, Gastrointestinal diseases, Cancer diseases categories
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Summaries for Granulosa Cell Tumor of the Ovary

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NIH Rare Diseases:42 Granulosa cell tumor of the ovary is a rare type of ovarian cancer that accounts for approximately 2% of all ovarian tumors. this type of tumor is known as a sex cord-stromal tumor and usually occurs in adults. granulosa cell tumors of the ovary cause higher than normal levels of estrogen in a woman's body.  the symptoms of this excess estrogen depend on the woman's menstrual status; the most common symptoms include early puberty for affected young girls, an increase in abdomen size or irregularities of menstrual cycles in premenopausal women, and abnormal uterine bleeding in postmenopausal women. the exact cause of granulosa cell tumors is unknown.  treatment consists of surgery to remove the tumor, and additional treatments may also be used depending on the extent of the tumor. last updated: 11/14/2011

MalaCards based summary: Granulosa Cell Tumor of the Ovary, also known as granulosa theca cell tumor of the ovary, is related to sertoli cell tumor and amenorrhea. An important gene associated with Granulosa Cell Tumor of the Ovary is ACTC1 (actin, alpha, cardiac muscle 1), and among its related pathways are Cardiac Progenitor Differentiation and Selected targets of CREB1. The compounds 111in-pentetreotide and estracyt have been mentioned in the context of this disorder. Affiliated tissues include ovary, breast and bone.

Aliases & Classifications for Granulosa Cell Tumor of the Ovary

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Granulosa Cell Tumor of the Ovary, Aliases & Descriptions:

Name: Granulosa Cell Tumor of the Ovary 42 62
Granulosa Theca Cell Tumor of the Ovary 42 62
Adult Granulosa Cell Tumor of the Ovary 42 62
Gastrointestinal Carcinoid Tumor 62
 
Granulosa Theca Cell Tumor 42
Gct of the Ovary 42
Gtct 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Gastrointestinal diseases


Related Diseases for Granulosa Cell Tumor of the Ovary

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Diseases related to Granulosa Cell Tumor of the Ovary via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1sertoli cell tumor31.0SYP, ENO2
2amenorrhea30.9PRL, INS
3endometrial carcinoma30.7CHGA, CEACAM3, KRT7
4breast cancer29.6KRT7, INS, CP, CEACAM3, SERPINA1, PRL
5hepatitis10.7
6peritonitis10.6
7somatostatinoma10.5CHGA
8melanotic neuroectodermal tumor10.5SYP
9fibroma10.5
10hypercalcemia10.5
11dysembryoplastic neuroepithelial tumor10.5SYP
12hemosiderosis10.5CP
13siderosis10.5CP
14central neurocytoma10.4SYP, CHGA
15cerebral primitive neuroectodermal tumor10.4ENO2
16rhabdoid tumor10.4SYP, ACTC1
17pancreatic islet cell tumors10.4CHGA, SYP
18sertoli-leydig cell tumor10.4
19tuberous sclerosis10.4
20hyperprolactinemia10.4
21pancytopenia10.4
22premature menopause10.4
23hemangiopericytoma10.4
24leiomyoma10.4
25leydig cell tumor10.4
26aromatase deficiency10.4
27gynandroblastoma10.4
28ovarian fibroma10.4
29monosomy 2210.4
30paraganglioma10.4ACTC1, SYP
31endocrine gland cancer10.4SYP, CHGA
32luteoma10.4
33neurofibroma10.3ACTC1, SYP
34empty sella syndrome10.3PRL
35spindle cell sarcoma10.3ACTC1, KRT7
36pituitary apoplexy10.3PRL
37adult respiratory distress syndrome10.3SERPINA1, CP
38pituitary carcinoma10.3PRL
39malignant fibroxanthoma10.3SERPINA1, ACTC1
40signet ring cell adenocarcinoma10.3CHGA, KRT7
41hyperinsulinemic hypoglycemia10.3CHGA, INS
42giant cell tumor10.3CEACAM3, ACTC1
43pancreatic ductal carcinoma10.3CHGA, KRT7
44granular cell tumor10.3ENO2, SYP
45olfactory neuroblastoma10.3SYP, ENO2
46adrenocortical carcinoma10.3CHGA, SYP
47abrikosov's tumor10.3KRT7, ACTC1
48adrenal cortical adenoma10.3CHGA, SYP
49ganglioneuroblastoma10.3SYP, ENO2
50neuroectodermal tumor10.3SYP, ENO2

Graphical network of the top 20 diseases related to Granulosa Cell Tumor of the Ovary:



Diseases related to granulosa cell tumor of the ovary

Symptoms for Granulosa Cell Tumor of the Ovary

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Drugs & Therapeutics for Granulosa Cell Tumor of the Ovary

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Drug clinical trials:

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Genetic Tests for Granulosa Cell Tumor of the Ovary

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Anatomical Context for Granulosa Cell Tumor of the Ovary

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MalaCards organs/tissues related to Granulosa Cell Tumor of the Ovary:

32
Ovary, Breast, Bone, Lung, Adrenal gland

Animal Models for Granulosa Cell Tumor of the Ovary or affiliated genes

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Publications for Granulosa Cell Tumor of the Ovary

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Articles related to Granulosa Cell Tumor of the Ovary:

(show top 50)    (show all 138)
idTitleAuthorsYear
1
Parameters for predicting granulosa cell tumor of the ovary: a single center retrospective comparative study. (25339044)
2014
2
Granulosa cell tumor of the ovary with high FDG uptake. (23640219)
2013
3
Successful treatment of adult-type granulosa cell tumor of the ovary by palliative radiotherapy. (22175649)
2012
4
Primary amenorrhea due to juvenile granulosa-cell tumor of the ovary: a case report. (22353374)
2012
5
Delayed menopause due to granulosa cell tumor of the ovary. (22408338)
2011
6
Prolonged survival following maximal cytoreductive effort for peritoneal metastases from recurrent granulosa cell tumor of the ovary. (21998767)
2011
7
Granulosa cell tumor of the ovary: time to launch a new prospective trial. (21998755)
2011
8
Medico-legal observations concerning a mortal case of granulosa cell tumor of the ovary in an 8-month-old infant. (21843743)
2011
9
Synchronous adult-type granulosa cell tumor of the ovary with ovarian fibroma: a case report. (22335040)
2011
10
FOXL2 mutation and large-scale genomic imbalances in adult granulosa cell tumors of the ovary. (22200085)
2011
11
Granulosa cell tumor of the ovary: cytologic findings. (20715655)
2010
12
Mutation of FOXL2 in granulosa-cell tumors of the ovary. (19516027)
2009
13
Prognostic factors in adult granulosa cell tumor of the ovary. (19198715)
2009
14
Juvenile granulosa cell tumor of the ovary presenting with pleural effusion and ascites. (19225930)
2009
15
Cystic fluid and fine needle aspiration cytopathology of cystic adult granulosa cell tumor of the ovary: a case report. (18500005)
2008
16
Glucose metabolism and angiogenesis in granulosa cell tumors of the ovary: activation of Akt, expression of M2PK, TKTL1 and VEGF. (18394773)
2008
17
Juvenile granulosa cell tumor of the ovary associated with hypercalcemia. (17849133)
2008
18
Juvenile granulosa cell tumor of the ovary associated with tuberous sclerosis. (16516278)
2006
19
Clinicopathological prognostic factors of adult granulosa cell tumor of the ovary--a study of 37 cases. (16366090)
2005
20
Monosomy 22 as a diagnostic aid in a case of late recurrence of adult granulosa cell tumor of the ovary. (15588863)
2005
21
Multifocal intrafollicular granulosa cell tumor of the ovary associated with an unusual germline p53 mutation. (15073606)
2004
22
Granulosa cell tumor of the ovary metastasizing to adrenal gland 13 years after initial diagnosis--diagnostic difficulties and immunohistochemical study]. (15058173)
2003
23
Granulosa cell tumor of the ovary: common findings and unusual appearances on CT and MR. (12439311)
2002
24
Juvenile granulosa cell tumor of the ovary: imprint cytology findings. (12462106)
2002
25
Hyperprolactinemia complicating juvenile granulosa cell tumor of the ovary. (11531301)
2001
26
Bone metastasis from a granulosa cell tumor of the ovary. (11606104)
2001
27
Case 5: gynecological. Granulosa cell tumor of the ovary with endometrial carcinoma. (10811416)
2000
28
Severe hypercalcemia in association with a juvenile granulosa cell tumor of the ovary. (10742079)
2000
29
Masculinizing granulosa cell tumor of the ovary in a postmenopausal woman. A case report. (10509308)
1999
30
Radiation treatment of advanced or recurrent granulosa cell tumor of the ovary. (10094877)
1999
31
Granulosa cell tumor of the ovary. (9880981)
1998
32
Prognostic factors in adult granulosa cell tumor of the ovary. (9149022)
1997
33
Management of advanced juvenile granulosa cell tumor of the ovary. (9038278)
1997
34
Juvenile granulosa cell tumor of the ovary in infants: a clinicopathologic study of three cases and review of the literature. (9165474)
1997
35
The management of granulosa cell tumor of the ovary--a case history. (8839909)
1996
36
Recurrent granulosa cell tumor of the ovary 37 years after initial diagnosis: a case report and review of the literature. (8774662)
1996
37
Juvenile granulosa-cell tumor of the ovary - interphase cytogenetics for chromosome-12 and chromosome-x and flow cytometric DNA-ploidy study. (21552888)
1995
38
Luteinized adult granulosa cell tumors of the ovary: a report of four cases. (7814191)
1994
39
Granulosa cell tumor of the ovary with diffuse true hepatic differentiation simulating stromal luteinization. (7680545)
1993
40
Congenital bilateral juvenile granulosa cell tumor of the ovary in leprechaunism: a case report. (8247952)
1993
41
Granulosa cell tumor of the ovary. (2178047)
1990
42
Prognostic value of flow cytometric DNA content analysis in granulosa cell tumor of the ovary. (2302667)
1990
43
Juvenile granulosa cell tumor of the ovary in children: a clinical study of 15 cases. (3373268)
1988
44
Cystic juvenile granulosa cell tumor of the ovary. (3176932)
1988
45
A clinicopathologic study of 92 cases of granulosa cell tumor of the ovary with special reference to the factors influencing prognosis. (1109770)
1975
46
Granulosa-cell tumor of the ovary. Report of case. (13766011)
1961
47
Granulosa cell tumor of the ovary. (20250086)
1947
48
Granulosa-cell tumor of the ovary. (21001409)
1946
49
Granulosa cell tumor of the ovary; a clinical and pathologic review of 62 cases. (21005311)
1945
50
GRANULOSA CELL TUMOR OF THE OVARY: REPORT OF A CASE. (17857589)
1940

Variations for Granulosa Cell Tumor of the Ovary

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Expression for genes affiliated with Granulosa Cell Tumor of the Ovary

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Expression patterns in normal tissues for genes affiliated with Granulosa Cell Tumor of the Ovary

Search GEO for disease gene expression data for Granulosa Cell Tumor of the Ovary.

Pathways for genes affiliated with Granulosa Cell Tumor of the Ovary

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Pathways related to Granulosa Cell Tumor of the Ovary according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7ACTC1, INS
29.6CHGA, INS
3
Show member pathways
FOXA transcription factor networks37
9.5SERPINA1, INS
49.5SERPINA1, INS
59.5INS, PRL

Compounds for genes affiliated with Granulosa Cell Tumor of the Ovary

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Compounds related to Granulosa Cell Tumor of the Ovary according to GeneCards/GeneDecks:

(show top 50)    (show all 91)
idCompoundScoreTop Affiliating Genes
1111in-pentetreotide449.8SYP, CHGA
2estracyt449.8ENO2, CHGA
3smcc449.7ENO2, CHGA, SYP
4metanephrine44 2410.6CHGA, ENO2
5l-amino acid449.6SYP, ENO2, CHGA
6homovanillic acid44 2410.5CHGA, ENO2, PRL
7streptozotocin449.5INS, SYP, CHGA
8flutamide44 61 1111.5CHGA, PRL, ENO2
9s 100449.4SYP, ACTC1, CHGA, ENO2
10reticulin449.4SYP, KRT7, ACTC1
11silver449.4ENO2, SYP, CHGA
125-hydroxyindoleacetic acid44 2410.3CEACAM3, CHGA, ENO2
13methanol44 2410.3KRT7, ACTC1, CHGA
14levodopa44 1110.2PRL, CHGA, CP
155-hydroxytryptamine449.2PRL, CHGA, SYP, ENO2
16uric acid44 2410.1INS, CP, ENO2
17ribonucleic acid449.1CHGA, ENO2, PRL, ACTC1
18epinephrine44 24 1111.0CP, CHGA, INS, PRL
19octreotide44 61 28 1112.0CHGA, PRL, INS, ENO2
20amine449.0ENO2, SYP, CHGA
21mucicarmine448.8ACTC1, SYP, KRT7, CEACAM3
22thyroxine44 249.8CP, PRL, CEACAM3, INS
23dopamine44 28 24 1111.8PRL, CHGA, CP, SYP, ENO2
24steroid448.7CEACAM3, ACTC1, CHGA, SYP, PRL
25norepinephrine44 24 1110.7PRL, SYP, CHGA, INS, ENO2
26fibrinogen448.6CHGA, INS, CEACAM3, CP, SERPINA1
27formaldehyde44 249.6ENO2, KRT7, SYP, ACTC1, CHGA
28glutamate448.6SYP, INS, CP, ENO2, CHGA
29b 723448.5CEACAM3, ACTC1, SYP, KRT7, CHGA
30sialic acid448.5ENO2, KRT7, CP, CEACAM3
31nitric oxide44 24 1110.5ENO2, CEACAM3, CHGA, SERPINA1, SYP
32lactate448.4ENO2, CEACAM3, CHGA, INS, CP
33iron44 249.4SERPINA1, CP, ACTC1, KRT7, ENO2
34oxygen44 249.3CEACAM3, CP, ACTC1, ENO2, SERPINA1, CHGA
35arginine448.2CP, CHGA, PRL, KRT7, INS
36retinoic acid44 249.1CP, CHGA, ENO2, KRT7, SYP, ACTC1
37glycogen44 249.1INS, ACTC1, CHGA, KRT7, ENO2, SYP
38dexamethasone44 50 28 1111.1ACTC1, CHGA, PRL, SYP, CP, INS
39hematoxylin448.0KRT7, ENO2, SYP, CHGA, CEACAM3, ACTC1
40cholesterol44 28 24 1110.8INS, SERPINA1, CP, ENO2, SYP, CEACAM3
41acth447.7SYP, CEACAM3, PRL, CHGA, ENO2, SERPINA1
42vegf447.6ENO2, KRT7, SYP, ACTC1, CP, CHGA
43paraffin447.6ACTC1, CEACAM3, KRT7, ENO2, CHGA, SERPINA1
44lipid447.6SYP, KRT7, CP, ENO2, SERPINA1, INS
45creatinine447.5SYP, CHGA, CEACAM3, ACTC1, INS, ENO2
46testosterone44 61 24 1110.2SYP, CHGA, CP, INS, KRT7, ENO2
47progesterone44 28 61 24 1111.1ENO2, ACTC1, SYP, SERPINA1, CEACAM3, PRL
48tyrosine447.0CHGA, ENO2, INS, SERPINA1, KRT7, SYP
49glucose446.9INS, KRT7, ACTC1, CEACAM3, PRL, ENO2
50estrogen446.2CP, CHGA, PRL, CEACAM3, ACTC1, SYP

GO Terms for genes affiliated with Granulosa Cell Tumor of the Ovary

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Cellular components related to Granulosa Cell Tumor of the Ovary according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.4INS, SERPINA1, CP, CHGA, PRL
2extracellular spaceGO:0056158.0INS, SERPINA1, CP, ACTC1, ENO2

Biological processes related to Granulosa Cell Tumor of the Ovary according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1acute-phase responseGO:0069539.5SERPINA1, INS

Products for genes affiliated with Granulosa Cell Tumor of the Ovary

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Sources for Granulosa Cell Tumor of the Ovary

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3CDC
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40NDF-RT
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