MCID: GRV001
MIFTS: 64

Graves' Disease malady

Rare diseases, Endocrine diseases, Immune diseases categories

Summaries for Graves' Disease

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NIH Rare Diseases:42 Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism). it is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. graves disease is the most common cause of hyperthyroidism and occurs most often in women over age 20. however, the disorder may occur at any age and may affect males as well. treatment may include radioiodine therapy, antithyroid drugs, and/or thyroid surgery. last updated: 5/11/2010

MalaCards based summary: Graves' Disease, also known as graves disease, is related to thyroiditis and myxedema. An important gene associated with Graves' Disease is CTLA4 (cytotoxic T-lymphocyte-associated protein 4), and among its related pathways are Metabolism of steroid hormones and vitamin D and Vitamin D synthesis. The compounds iodotyrosine and diiodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include thyroid gl, thyroid and eye, and related mouse phenotypes are skeleton and immune system.

Disease Ontology:9 An autoimmune disease of endocrine system that involves production of excessive amount of thyroid hormones, located in thyroid gland.

Genetics Home Reference:22 Graves disease is a condition that affects the function of the thyroid, which is a butterfly-shaped gland in the lower neck. The thyroid makes hormones that help regulate a wide variety of critical body functions. For example, thyroid hormones influence growth and development, body temperature, heart rate, menstrual cycles, and weight. In people with Graves disease, the thyroid is overactive and makes more hormones than the body needs. The condition usually appears in mid-adulthood, although it may occur at any age.

Wikipedia:64 Graves\' disease (or Flajani-Basedow-Graves disease) is an autoimmune disease. It most commonly affects... more...

Description from OMIM:46 275000

Aliases & Classifications for Graves' Disease

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Graves' Disease, Aliases & Descriptions:

Name: Graves' Disease 9 42 22
Graves Disease 9 22 11 44 61
Exophthalmic Goiter 9 42 22
Grave's Disease 9 23 61
Toxic Diffuse Goiter with Exophthalmos 9 61
Toxic Diffuse Goiter 22 61
Basedow's Disease 22 61
 
Basedow Disease 42 22
Hyperthyroidism, Autoimmune 61
Autoimmune Hyperthyroidism 22
Toxic Multinodular Goiter 61
Graves' Hyperthyroidism 42
Exophthalmic Goitre 61
Parry Disease 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases, Immune diseases


Related Diseases for Graves' Disease

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Diseases in the Graves' Disease family:

Graves Disease 1 Graves Disease 2

Diseases related to Graves' Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 252)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.7PTPN22, TPO, TG, TSHR, CTLA4
2myxedema31.2TPO, TG, TSHR
3thyrotoxicosis31.2TPO, TG, TSHR
4struma ovarii31.1TG, TSHR
5hypothyroidism31.1TPO, TG, TSHR
6goiter31.1DIO2, TSHR, LMOD1, TG, TPO
7subacute thyroiditis31.1TSHR, TG, TPO
8autoimmune thyroiditis31.0TG, TPO
9multinodular goiter31.0TSHR, TG, TPO
10type 1 diabetes mellitus30.8CTLA4, TPO
11diabetes mellitus30.8CYP27B1, PTPN22, GC, CTLA4
12thyroid adenoma30.7DIO2, TSHR, TG, TPO
13wegener's granulomatosis30.7CTLA4
14vitiligo30.7PTPN22, TPO, CTLA4
15papillary thyroid carcinoma30.6TSHR, TG, TPO
16follicular thyroid carcinoma30.6TSHR, TG
17nontoxic goiter30.6TSHR, TG, TPO
18pernicious anemia30.5TPO, TG
19papillary carcinoma30.5TPO, TG, TSHR
20adenoma30.5TPO, TG, LMOD1, TSHR, DIO2, CTLA4
21thyroid agenesis30.4TSHR, TG
22hyperthyroidism30.4PTPN22, IGES, TPO, TG, LMOD1, TSHR
23nodular goiter30.4TNFRSF4, TPO, TG, TSHR, CTLA4
24toxic diffuse goiter30.4TPO, TG, TSHR
25congenital hypothyroidism30.3TSHR, TG, TPO
26addison's disease30.3CYP27B1, PTPN22, TPO, TG, CTLA4
27plummer's disease30.3TPO, TG
28connective tissue disease30.2PTPN22, CD40, CTLA4
29turner syndrome30.2TG, TPO
30hyperthyroxinemia30.2TPO, TSHR
31celiac disease30.1PTPN22, TPO, TG, CTLA4
32multiple sclerosis29.8CYP27B1, PTPN22, HTLVR, GC, CD40, CTLA4
33t-cell leukemia29.6TNFRSF4, HTLVR, CD40
34rheumatoid arthritis29.4CYP27B1, TNFRSF4, PTPN22, HTLVR, CD40, CTLA4
35systemic lupus erythematosus29.4TNFRSF4, PTPN22, TPO, TSHR, CD40, CTLA4
36melanoma29.1CYP27B1, TNFRSF4, TSHR, CD40, CTLA4
37leukemia28.9CYP27B1, TNFRSF4, TSHR, HTLVR, CD40
38thymic hyperplasia10.6
39exophthalmos10.5
40thyroid cancer10.5
41hepatitis10.4
42steroid-induced glaucoma10.4FGFR1OP, LMOD1
43mediastinitis10.4
44pendred syndrome10.3TG, TPO
45insulin autoimmune syndrome10.3
46thyrotoxic periodic paralysis10.3
47myasthenia gravis10.3
48factor vii deficiency10.3CTLA4, TG
49thyrotropin deficiency, isolated10.3TG, TPO
50arthritis10.2

Graphical network of the top 20 diseases related to Graves' Disease:



Diseases related to graves' disease

Symptoms for Graves' Disease

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Clinical features from OMIM:

275000

Drugs & Therapeutics for Graves' Disease

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Drug clinical trials:

Search ClinicalTrials for Graves' Disease

Search NIH Clinical Center for Graves' Disease

Genetic Tests for Graves' Disease

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Genetic tests related to Graves' Disease:

id Genetic test Affiliating Genes
1 Graves' Disease23

Anatomical Context for Graves' Disease

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MalaCards organs/tissues related to Graves' Disease:

32
Thyroid, Eye, Heart, T cells, Skin, Bone, B cells, Testes, Breast, Endothelial, Thymus, Pituitary, Skeletal muscle, Liver, Ovary, Neutrophil, Bone marrow, Lymph node, Brain, Monocytes, Nk cells

FMA organs/tissues related to Graves' Disease:

15
Thyroid gl

Animal Models for Graves' Disease or affiliated genes

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MGI Mouse Phenotypes related to Graves' Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.7CYP27B1, TPO, DIO2, GC, CD40, CTLA4
2MP:00053878.7TNFRSF4, PTPN22, TPO, TSHR, CD40, CTLA4
3MP:00053798.7CTLA4, CYP27B1, PTPN22, TPO, TG, TSHR
4MP:00053978.4CYP27B1, TNFRSF4, PTPN22, TPO, TG, TSHR
5MP:00053767.8CYP27B1, PTPN22, DBP, TPO, TG, TSHR

Publications for Graves' Disease

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Articles related to Graves' Disease:

(show top 50)    (show all 1311)
idTitleAuthorsYear
1
Radioiodine therapy in patients with Graves' disease and the effects of prior carbimazole therapy. (25285287)
2014
2
Left-shifted relation between calcium and parathyroid hormone in Graves' Disease. (24248181)
2013
3
Maximinus Daia, a Roman emperor who may have had Graves' disease and died of a thyrotoxic crisis. (23624140)
2013
4
Anaplastic thyroid carcinoma following radioactive iodine therapy for graves' disease. (24396653)
2013
5
The negative correlation between thyrotropin receptor-stimulating antibodies and bone mineral density in postmenopausal patients with Graves' disease. (23612147)
2013
6
Unexpected conversion from hypothyroidism to an euthyroid state due to Graves' disease in a patient with an ectopic thyroid. (24282039)
2013
7
Mental health status and factors that influence the course of Graves' disease and antithyroid treatments. (23070829)
2012
8
Graves' disease in two pregnancies complicated by fetal goitrous hypothyroidism: successful in utero treatment with levothyroxine. (21162688)
2011
9
Thymic Hyperplasia Associated with Graves' Disease in a 10-year-old Boy. (23926397)
2011
10
Graves' disease. When thyroid hormones run wild. (21200368)
2011
11
Serum chemokine (C-X-C motif ) ligand 10 levels are elevated in patients with Graves' disease in long-term remission. (20144041)
2010
12
Association analysis of polymorphisms in IL-3, IL-4, IL-5, IL-9, and IL-13 with Graves' disease. (20332709)
2010
13
Cancer risk in patients hospitalised for Graves' disease: a population-based cohort study in Sweden. (20354521)
2010
14
The interleukin-1 family gene polymorphisms and Graves' disease. (20400062)
2010
15
Thyroid stimulating hormone receptor (TSHR) intron 1 variants are major risk factors for Graves' disease in three European Caucasian cohorts. (21124799)
2010
16
Somatostatin receptor 2 expression determined by immunohistochemistry in cold thyroid nodules exceeds that of hot thyroid nodules, papillary thyroid carcinoma, and Graves' disease. (20450431)
2010
17
Resistance to thyroid hormone in a patient with coexisting Graves' disease. (20151830)
2010
18
Clinical features of primary hyperthyroidism caused by Graves' disease admixed with resistance to thyroid hormone (P453T). (20574139)
2010
19
Familial risks for hospitalized Graves' disease and goiter. (19661127)
2009
20
Angiogenic study in Graves' disease treated with thyroid arterial embolization. (19796574)
2009
21
Severe ophthalmopathy developing after treatment of coexisting malignant struma ovarii and Graves' disease. (19772400)
2009
22
High iodine (substrate) turnover Graves' disease: the intriguing 'rapid responder' variant of thyrotoxicosis. (18941129)
2008
23
Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. (18449200)
2008
24
Association of tumour necrosis factor alpha (TNF-alpha) polymorphisms with Graves' disease: A meta-analysis. (18472000)
2008
25
B cells from patients with Graves' disease aberrantly express the IGF-1 receptor: implications for disease pathogenesis. (18832736)
2008
26
The adaptation and relationship of FGF-23 to changes in mineral metabolism in Graves' disease. (17437520)
2007
27
Correlation between serum osteoprotegerin and biomarkers of bone metabolism during anti-thyroid treatment in patients with Graves' disease. (16912510)
2006
28
Elephantiasis Nostras Verrucosa: a rare thyroid dermopathy in Graves' disease. (16121817)
2005
29
A haplotype of the CYP27B1 promoter is associated with autoimmune Addison's disease but not with Graves' disease in a UK population. (15956353)
2005
30
Gray-scale and color Doppler sonographic findings in a case of mesenteric Castleman's disease incidentally detected in a patient with Graves' disease. (16196012)
2005
31
Pretibial myxedema, ophthalmopathy and acropachy in a male patient with Graves' disease. (17642674)
2004
32
Reversible mitral valve prolapse and mitral regurgitation in children with Graves' disease. (15506680)
2004
33
Dermopathy of Graves' disease (pretibial myxedema): long-term outcome. (11836263)
2002
34
Frequency of appearance of myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) in Graves' disease patients treated with propylthiouracil and the relationship between MPO-ANCA and clinical manifestations. (11380496)
2001
35
Elephantiasic pretibial myxedema: insight into and a hypothesis regarding the pathogenesis of the extrathyroidal manifestations of Graves' disease. (11014313)
2000
36
An elevation of serum immunoglobulin E provides a new aspect of hyperthyroid Graves' disease. (10946880)
2000
37
Thyroid-associated ophthalmopathy in black South African patients with Graves' disease: relationship to antiflavoprotein antibodies. (9848717)
1998
38
Increased serum concentration of interleukin-5 in patients with Graves' disease and Hashimoto's thyroiditis. (9545110)
1998
39
CTLA4 gene polymorphism confers susceptibility to Graves' disease in Japanese. (9459626)
1997
40
CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus. (8989248)
1997
41
Expression of membrane and soluble intercellular adhesion molecule-1 in Graves' disease. (9343311)
1997
42
Binding of antithyrotropin receptor autoantibodies in Graves' disease serum to nascent, in vitro translated thyrotropin receptor: ability to map epitopes recognized by antibodies. (8636291)
1996
43
Systemic scleroderma associated with Graves' disease. (9037923)
1996
44
CD31, CD62E, and CD62P identify a specific pattern of endothelial activation in Graves' disease. (7542186)
1995
45
Identification of thyroid stimulating hormone receptor-specific T cells in Graves' disease thyroid using autoantigen-transfected Epstein-Barr virus-transformed B cell lines. (7615799)
1995
46
A case of pretibial myxedema associated with Graves' disease: an immunohistochemical study of serum-derived hyaluronan-associated protein. (8648004)
1995
47
Soluble intercellular adhesion molecule-1 (sICAM-1) in Graves' disease. (7866729)
1994
48
Dynamic changes in soluble interleukin-2 receptor levels during treatment of Graves' disease. Correlation with disease activity. (1916654)
1991
49
Association of HLA antigen and restriction fragment length polymorphism of T cell receptor beta-chain gene with Graves' disease and Hashimoto's thyroiditis. (2567295)
1989
50
Ultrastructural and immunological findings in Graves' disease with pretibial myxedema. (6989863)
1980

Variations for Graves' Disease

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Expression for genes affiliated with Graves' Disease

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Expression patterns in normal tissues for genes affiliated with Graves' Disease

Search GEO for disease gene expression data for Graves' Disease.

Pathways for genes affiliated with Graves' Disease

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Compounds for genes affiliated with Graves' Disease

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Compounds related to Graves' Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1iodotyrosine44 2511.4TPO, TG
2diiodotyrosine4410.4TPO, TG
3n-bromoacetyl-3,3,5-triiodo-l-thyronine4410.3LMOD1, DIO2
4perchlorate4410.3TPO, TG
53,3-diiodothyronine4410.3LMOD1, DIO2
6alfacalcidol44 60 1212.3CYP27B1, GC
7carbimazole44 1211.3TPO, TSHR
8sodium iodide4410.2TPO, TG, TSHR
9selenium44 2511.1TG, TPO, DIO2
10liothyronine50 25 1212.1TPO, DIO2
11amiodarone44 50 29 1213.1LMOD1, TG, TPO
12prednisolone44 29 1212.0TSHR, CD40, TG
13methimazole44 3 1212.0TPO, TSHR, DIO2, TG
14sialic acid4410.0TSHR, TG, GC
15amino acid4410.0TPO, TSHR
16hydrocortisone44 3 60 1212.9CD40, TPO, TG
17ionomycin449.9TNFRSF4, TSHR, CD40, CTLA4
18chloramphenicol44 3 50 1212.8GC, TSHR, CD40, CYP27B1
19dithiothreitol449.8TPO, CD40, DIO2, LMOD1
20paraffin449.8CD40, TSHR, TG, CYP27B1
21ribonucleic acid449.7CD40, TSHR, TG, TPO, DIO2
22gliadin449.7TPO, TG
23genistein44 29 60 3 25 1214.7CD40, TG, CYP27B1, TPO
24propylthiouracil44 3 1211.7TSHR, LMOD1, TG, TPO, DIO2
25125i449.7TPO, LMOD1, TSHR, DIO2, TG
26iodide44 2510.7TPO, DIO2, TSHR, LMOD1, TG
27triiodothyronine449.6TPO, TG, LMOD1, DIO2, TSHR
28adenylate449.6TG, TPO, CD40, TSHR, GC
29forskolin44 50 1211.6TSHR, CD40, DIO2, CYP27B1, TPO
30cycloheximide449.6CYP27B1, TPO, TG, DIO2, CD40
31threonine449.6TSHR, DIO2, GC, CD40, CTLA4
32lysine449.6CYP27B1, CTLA4, TSHR, TPO
33hydrogen44 2510.6TSHR, TPO, CD40, CYP27B1
34thymidine44 2510.6CTLA4, CD40, TSHR, TG
35allergens449.5CTLA4, CD40, IGES
36iodine44 2510.5TG, TSHR, CTLA4, DIO2, LMOD1, TPO
37thyroxine44 2510.4GC, DIO2, TSHR, LMOD1, TG, TPO
38glucose449.4GC, CTLA4, CD40, DIO2, TSHR, CYP27B1
39cholesterol44 29 25 1212.4CD40, GC, TSHR, CYP27B1, TPO, CTLA4
40lipid449.3CD40, CYP27B1, CTLA4, TSHR, GC, TPO
41glutamate449.3PTPN22, CTLA4, CD40, TG, TPO, TSHR
42acetylcholine44 50 29 25 1213.3TPO, IGES, TG, CTLA4
43retinoic acid44 2510.2TG, TPO, CYP27B1, DIO2, GC, CD40
44estrogen449.2GC, CTLA4, DIO2, TSHR, LMOD1, TG
45oligonucleotide449.1HTLVR, TSHR, TPO, CYP27B1, CD40
46cyclosporin a44 29 6011.1CTLA4, CD40, IGES, TNFRSF4, TG
47cysteine448.9TPO, CD40, LMOD1, DIO2, TSHR, CTLA4
48steroid448.8CTLA4, CD40, GC, TPO, CYP27B1, IGES
49calcium44 50 25 1211.7GC, DIO2, TSHR, TPO, CYP27B1, CTLA4
50tyrosine448.7CTLA4, DIO2, TSHR, LMOD1, TG, TPO

GO Terms for genes affiliated with Graves' Disease

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Cellular components related to Graves' Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.4CTLA4, CD40, TNFRSF4
2integral component of plasma membraneGO:0058879.2CTLA4, CD40, TSHR, TPO, TNFRSF4

Biological processes related to Graves' Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell proliferationGO:0308909.9CD40, TNFRSF4
2hormone biosynthetic processGO:0424469.8DIO2, TG, TPO
3thyroid hormone generationGO:0065909.7TPO, TG, DIO2
4vitamin D metabolic processGO:0423599.7GC, CYP27B1

Products for genes affiliated with Graves' Disease

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Sources for Graves' Disease

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23GTR
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26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
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36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
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51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
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