MCID: GRV001
MIFTS: 51

Graves' Disease malady

Rare diseases, Endocrine diseases, Immune diseases categories
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Summaries for Graves' Disease

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NIH Rare Diseases:42 Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism). it is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. graves disease is the most common cause of hyperthyroidism and occurs most often in women over age 20. however, the disorder may occur at any age and may affect males as well. treatment may include radioiodine therapy, antithyroid drugs, and/or thyroid surgery. last updated: 5/11/2010

MalaCards based summary: Graves' Disease, also known as graves disease, is related to thyroiditis and hyperthyroidism. An important gene associated with Graves' Disease is CTLA4 (cytotoxic T-lymphocyte-associated protein 4). Affiliated tissues include thyroid gl, thyroid and eye.

Disease Ontology:8 An autoimmune disease of endocrine system that involves production of excessive amount of thyroid hormones, located in thyroid gland.

Genetics Home Reference:21 Graves disease is a condition that affects the function of the thyroid, which is a butterfly-shaped gland in the lower neck. The thyroid makes hormones that help regulate a wide variety of critical body functions. For example, thyroid hormones influence growth and development, body temperature, heart rate, menstrual cycles, and weight. In people with Graves disease, the thyroid is overactive and makes more hormones than the body needs. The condition usually appears in mid-adulthood, although it may occur at any age.

Wikipedia:65 Graves\' disease (or Flajani-Basedow-Graves disease) is an autoimmune disease. It most commonly affects... more...

Description from OMIM:46 275000

Aliases & Classifications for Graves' Disease

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Graves' Disease, Aliases & Descriptions:

Name: Graves' Disease 8 42 21
Graves Disease 8 21 10 44 62
Exophthalmic Goiter 8 42 21
Grave's Disease 8 22 62
Toxic Diffuse Goiter with Exophthalmos 8 62
Toxic Diffuse Goiter 21 62
Basedow's Disease 21 62
 
Basedow Disease 42 21
Hyperthyroidism, Autoimmune 62
Autoimmune Hyperthyroidism 21
Toxic Multinodular Goiter 62
Graves' Hyperthyroidism 42
Exophthalmic Goitre 62
Parry Disease 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases, Immune diseases


Related Diseases for Graves' Disease

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Graphical network of the top 20 diseases related to Graves' Disease:



Diseases related to graves' disease

Symptoms for Graves' Disease

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Clinical features from OMIM:

275000

Drugs & Therapeutics for Graves' Disease

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Drug clinical trials:

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Search NIH Clinical Center for Graves' Disease

Genetic Tests for Graves' Disease

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Genetic tests related to Graves' Disease:

id Genetic test Affiliating Genes
1 Graves' Disease22

Anatomical Context for Graves' Disease

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MalaCards organs/tissues related to Graves' Disease:

32
Thyroid, Eye, Heart, T cells, Skin, Bone, B cells, Testes, Breast, Endothelial, Thymus, Pituitary, Skeletal muscle, Liver, Ovary, Neutrophil, Bone marrow, Lymph node, Brain, Monocytes, Nk cells

FMA organs/tissues related to Graves' Disease:

14
Thyroid gl

Animal Models for Graves' Disease or affiliated genes

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Publications for Graves' Disease

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Articles related to Graves' Disease:

(show top 50)    (show all 1311)
idTitleAuthorsYear
1
Radioiodine therapy in patients with Graves' disease and the effects of prior carbimazole therapy. (25285287)
2014
2
Left-shifted relation between calcium and parathyroid hormone in Graves' Disease. (24248181)
2013
3
Maximinus Daia, a Roman emperor who may have had Graves' disease and died of a thyrotoxic crisis. (23624140)
2013
4
Anaplastic thyroid carcinoma following radioactive iodine therapy for graves' disease. (24396653)
2013
5
The negative correlation between thyrotropin receptor-stimulating antibodies and bone mineral density in postmenopausal patients with Graves' disease. (23612147)
2013
6
Unexpected conversion from hypothyroidism to an euthyroid state due to Graves' disease in a patient with an ectopic thyroid. (24282039)
2013
7
Mental health status and factors that influence the course of Graves' disease and antithyroid treatments. (23070829)
2012
8
Graves' disease in two pregnancies complicated by fetal goitrous hypothyroidism: successful in utero treatment with levothyroxine. (21162688)
2011
9
Thymic Hyperplasia Associated with Graves' Disease in a 10-year-old Boy. (23926397)
2011
10
Graves' disease. When thyroid hormones run wild. (21200368)
2011
11
Serum chemokine (C-X-C motif ) ligand 10 levels are elevated in patients with Graves' disease in long-term remission. (20144041)
2010
12
Association analysis of polymorphisms in IL-3, IL-4, IL-5, IL-9, and IL-13 with Graves' disease. (20332709)
2010
13
Cancer risk in patients hospitalised for Graves' disease: a population-based cohort study in Sweden. (20354521)
2010
14
The interleukin-1 family gene polymorphisms and Graves' disease. (20400062)
2010
15
Thyroid stimulating hormone receptor (TSHR) intron 1 variants are major risk factors for Graves' disease in three European Caucasian cohorts. (21124799)
2010
16
Somatostatin receptor 2 expression determined by immunohistochemistry in cold thyroid nodules exceeds that of hot thyroid nodules, papillary thyroid carcinoma, and Graves' disease. (20450431)
2010
17
Resistance to thyroid hormone in a patient with coexisting Graves' disease. (20151830)
2010
18
Clinical features of primary hyperthyroidism caused by Graves' disease admixed with resistance to thyroid hormone (P453T). (20574139)
2010
19
Familial risks for hospitalized Graves' disease and goiter. (19661127)
2009
20
Angiogenic study in Graves' disease treated with thyroid arterial embolization. (19796574)
2009
21
Severe ophthalmopathy developing after treatment of coexisting malignant struma ovarii and Graves' disease. (19772400)
2009
22
High iodine (substrate) turnover Graves' disease: the intriguing 'rapid responder' variant of thyrotoxicosis. (18941129)
2008
23
Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. (18449200)
2008
24
Association of tumour necrosis factor alpha (TNF-alpha) polymorphisms with Graves' disease: A meta-analysis. (18472000)
2008
25
B cells from patients with Graves' disease aberrantly express the IGF-1 receptor: implications for disease pathogenesis. (18832736)
2008
26
The adaptation and relationship of FGF-23 to changes in mineral metabolism in Graves' disease. (17437520)
2007
27
Correlation between serum osteoprotegerin and biomarkers of bone metabolism during anti-thyroid treatment in patients with Graves' disease. (16912510)
2006
28
Elephantiasis Nostras Verrucosa: a rare thyroid dermopathy in Graves' disease. (16121817)
2005
29
A haplotype of the CYP27B1 promoter is associated with autoimmune Addison's disease but not with Graves' disease in a UK population. (15956353)
2005
30
Gray-scale and color Doppler sonographic findings in a case of mesenteric Castleman's disease incidentally detected in a patient with Graves' disease. (16196012)
2005
31
Pretibial myxedema, ophthalmopathy and acropachy in a male patient with Graves' disease. (17642674)
2004
32
Reversible mitral valve prolapse and mitral regurgitation in children with Graves' disease. (15506680)
2004
33
Dermopathy of Graves' disease (pretibial myxedema): long-term outcome. (11836263)
2002
34
Frequency of appearance of myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) in Graves' disease patients treated with propylthiouracil and the relationship between MPO-ANCA and clinical manifestations. (11380496)
2001
35
Elephantiasic pretibial myxedema: insight into and a hypothesis regarding the pathogenesis of the extrathyroidal manifestations of Graves' disease. (11014313)
2000
36
An elevation of serum immunoglobulin E provides a new aspect of hyperthyroid Graves' disease. (10946880)
2000
37
Thyroid-associated ophthalmopathy in black South African patients with Graves' disease: relationship to antiflavoprotein antibodies. (9848717)
1998
38
Increased serum concentration of interleukin-5 in patients with Graves' disease and Hashimoto's thyroiditis. (9545110)
1998
39
CTLA4 gene polymorphism confers susceptibility to Graves' disease in Japanese. (9459626)
1997
40
CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus. (8989248)
1997
41
Expression of membrane and soluble intercellular adhesion molecule-1 in Graves' disease. (9343311)
1997
42
Binding of antithyrotropin receptor autoantibodies in Graves' disease serum to nascent, in vitro translated thyrotropin receptor: ability to map epitopes recognized by antibodies. (8636291)
1996
43
Systemic scleroderma associated with Graves' disease. (9037923)
1996
44
CD31, CD62E, and CD62P identify a specific pattern of endothelial activation in Graves' disease. (7542186)
1995
45
Identification of thyroid stimulating hormone receptor-specific T cells in Graves' disease thyroid using autoantigen-transfected Epstein-Barr virus-transformed B cell lines. (7615799)
1995
46
A case of pretibial myxedema associated with Graves' disease: an immunohistochemical study of serum-derived hyaluronan-associated protein. (8648004)
1995
47
Soluble intercellular adhesion molecule-1 (sICAM-1) in Graves' disease. (7866729)
1994
48
Dynamic changes in soluble interleukin-2 receptor levels during treatment of Graves' disease. Correlation with disease activity. (1916654)
1991
49
Association of HLA antigen and restriction fragment length polymorphism of T cell receptor beta-chain gene with Graves' disease and Hashimoto's thyroiditis. (2567295)
1989
50
Ultrastructural and immunological findings in Graves' disease with pretibial myxedema. (6989863)
1980

Variations for Graves' Disease

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Expression for genes affiliated with Graves' Disease

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Expression patterns in normal tissues for genes affiliated with Graves' Disease

Search GEO for disease gene expression data for Graves' Disease.

Pathways for genes affiliated with Graves' Disease

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Compounds for genes affiliated with Graves' Disease

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GO Terms for genes affiliated with Graves' Disease

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Products for genes affiliated with Graves' Disease

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Sources for Graves' Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet