MCID: GRV001
MIFTS: 63

Graves' Disease malady

Summaries for Graves' Disease

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8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism). it is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. graves disease is the most common cause of hyperthyroidism and occurs most often in women over age 20. however, the disorder may occur at any age and may affect males as well. treatment may include radioiodine therapy, antithyroid drugs, and/or thyroid surgery. last updated: 5/11/2010

MalaCards: Graves' Disease, also known as graves disease, is related to thyroiditis and hyperthyroidism. An important gene associated with Graves' Disease is CTLA4 (cytotoxic T-lymphocyte-associated protein 4), and among its related pathways are Allograft rejection and CD28 co-stimulation. The compounds tyrosine and cysteine have been mentioned in the context of this disorder. Affiliated tissues include thyroid gl, thyroid and eye, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 An autoimmune disease of endocrine system that involves production of excessive amount of thyroid hormones, located in thyroid gland.

Genetics Home Reference:21 Graves disease is a condition that affects the function of the thyroid, which is a butterfly-shaped gland in the lower neck. The thyroid makes hormones that help regulate a wide variety of critical body functions. For example, thyroid hormones influence growth and development, body temperature, heart rate, menstrual cycles, and weight. In people with Graves disease, the thyroid is overactive and makes more hormones than the body needs. The condition usually appears in mid-adulthood, although it may occur at any age.

Wikipedia:63 Graves\' disease (or Basedow-Graves disease) is an autoimmune disease. It most commonly affects the... more...

Description from OMIM:46 275000

Aliases & Classifications for Graves' Disease

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21Genetics Home Reference, 60UMLS, 8Disease Ontology, 42NIH Rare Diseases, 22GTR, 10DISEASES, 44Novoseek, 46OMIM, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

graves' disease 8 42 21
graves disease 8 22 21 10 44 60
exophthalmic goiter 8 42 21
toxic diffuse goiter 21 60
basedow disease 42 21
toxic diffuse goiter with exophthalmos 8
autoimmune hyperthyroidism 21
toxic multinodular goiter 60
graves' hyperthyroidism 42
basedow's disease 21
grave's disease 8
parry disease 42


Related Diseases for Graves' Disease

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17GeneCards, 18GeneDecks
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Diseases in the Graves' Disease family:

Graves Disease 4 Graves Disease 3
Graves Disease 1 Graves Disease 2

Diseases related to Graves' Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 276)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.7TSHR, TPO, TG, PTPN22, CTLA4
2hyperthyroidism31.2CTLA4, DIO2, PTPN22, TPO, TG, CD40
3goiter31.1DIO2, TG, TPO, TSHR, LMOD1
4myxedema30.9TSHR, TG, TPO
5thyrotoxicosis30.9TG, TPO, TSHR
6hypothyroidism30.9TSHR, TG, TPO
7autoimmune thyroiditis30.8TPO, TG
8diabetes mellitus30.8HLA-DQA1, PTPN22, CTLA4, CYP27B1
9subacute thyroiditis30.8TSHR, TG, TPO
10nodular goiter30.7TSHR, CD80, TPO, CTLA4, TG
11multinodular goiter30.7TG, TPO, TSHR
12thyroid cancer30.7TPO, TG, DIO2, TSHR
13adenoma30.6TG, TPO, TSHR, LMOD1, DIO2, CTLA4
14papillary carcinoma30.6TSHR, TPO, TG
15hepatitis30.6CTLA4
16struma ovarii30.6TG, TSHR
17papillary thyroid carcinoma30.5TSHR, TPO, TG
18addison's disease30.5CYP27B1, TG, TPO, PTPN22, CTLA4
19nontoxic goiter30.4TPO, TG, TSHR
20myasthenia gravis30.4CD80, CTLA4
21arthritis30.4CTLA4, IL13, PTPN22, PSMB9, CD80
22hepatitis c30.4TSHR, PSMB9, CTLA4
23endemic goiter30.4TPO, TSHR, TG
24vitiligo30.3CTLA4, TPO, PTPN22
25hypoparathyroidism30.3CTLA4
26rheumatoid arthritis30.2CD40, CD80, IL13, CYP27B1, CTLA4, HTLVR
27vasculitis30.2CD80, CTLA4
28follicular thyroid carcinoma30.2TG, TSHR
29adenocarcinoma30.1CYP27B1, CD80, DIO2, CT49
30multiple sclerosis30.1HLA-DQA1, CD40, CYP27B1, IL13, PTPN22, CTLA4
31systemic lupus erythematosus30.1TSHR, CD40, CD80, CTLA4, PTPN22, HLA-DQA1
32breast cancer30.1CYP27B1, CTLA4, CD40, CD80, LMOD1
33toxic diffuse goiter30.1TPO, TG, TSHR
34connective tissue disease30.1CTLA4, CD40, PTPN22
35congenital hypothyroidism30.1TG, TPO, TSHR
36pernicious anemia30.1TPO, TG
37severe combined immunodeficiency30.1CD40
38melanoma29.8CTLA4, CD40, CD80, CT49, CYP27B1, PSMB9
39celiac disease29.8TG, CTLA4, TPO, PTPN22, HLA-DQA1
40leukemia29.8TSHR, HTLVR, CYP27B1, CD40, CD80
41systemic scleroderma29.8PTPN22, CTLA4, IL13, CD80
42hodgkin's lymphoma29.8IL13, CD40, PSMB9, CD80
43sarcoidosis29.8CD80, IL13, CYP27B1
44wegener's granulomatosis29.8CD80, CTLA4
45uveitis29.8CTLA4
46plummer's disease29.8TPO, TG
47diabetic ketoacidosis29.8CTLA4
48thymoma29.8CTLA4
49allergic rhinitis29.8CTLA4, IL13
50hyperthyroxinemia29.8TSHR, TPO

Graphical network of the top 20 diseases related to Graves' Disease:



Diseases related to graves' disease

Clinical Features for Graves' Disease

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46OMIM
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Clinical features from OMIM:

275000

Drugs & Therapeutics for Graves' Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Graves' Disease

Drug clinical trials:

Search ClinicalTrials for Graves' Disease

Search NIH Clinical Center for Graves' Disease

Search CenterWatch for Graves' Disease

Genetic Tests for Graves' Disease

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22GTR
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Genetic tests related to Graves' Disease:

id Genetic test Affiliating Genes
1 Graves' Disease22

Anatomical Context for Graves' Disease

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Graves' Disease:

32
Thyroid, Eye, Heart, T cells, Skin, Bone, B cells, Testes, Breast, Endothelial, Thymus, Liver, Pituitary, Skeletal muscle, Brain, Ovary, Bone marrow, Lymph node, Monocytes

FMA organs/tissues related to Graves' Disease:

14
Thyroid gl

Animal Models for Graves' Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Graves' Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539711.5TG, PSMB9, CTLA4, HLA-DQA1, CD40, CD80
2MP:000538711.2CD40, HLA-DQA1, CTLA4, PSMB9, CD80, CYP27B1
3MP:000537910.9TG, TSHR, CYP27B1, CD80

Publications for Graves' Disease

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Sources:
50PubMed
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Articles related to Graves' Disease:

(show top 50)    (show all 1323)
idTitleAuthorsYear
1
Graves' disease as immune reconstitution disease in HIV-positive patients is associated with naive and primary thymic emigrant CD4+ T-cell recovery. (23939238)
2014
2
Impact of treatment with methimazole on the Bcl-2 expression in CD8+ peripheral blood lymphocytes in children with Graves' disease. (24364474)
2013
3
Elevated serum immunoglobulin G4 levels in patients with Graves' disease and their clinical implications. (24256421)
2013
4
Role of color Doppler in differentiation of Graves' disease and thyroiditis in thyrotoxicosis. (23671754)
2013
5
Serum vitamin D levels are decreased in patients without remission of Graves' disease. (22983830)
2013
6
Unilateral gynecomastia and hypokalemic periodic paralysis as first manifestations of Graves' disease. (23276903)
2013
7
Unusual problems in the management of hyperthyroid Graves' disease. (23435045)
2013
8
Mental health status and factors that influence the course of Graves' disease and antithyroid treatments. (23070829)
2012
9
Evidence for higher success rates and successful treatment earlier in Graves' disease with higher radioactive iodine doses. (22953990)
2012
10
The role of oxidative stress on the pathogenesis of graves' disease. (22175033)
2012
11
Involvement of inducible costimulator ligand (ICOSL) expression in thyroid tissue in hyperthyroidism of Graves' disease patients. (22706735)
2012
12
Juvenile Graves' disease with opthalmopathy, lymphadenopathy, accelerated growth and congestive cardiac failure. (21706242)
2012
13
Relative levels of the inflammatory cytokine TNFI+ and the soluble CD40 ligand profile in serum correlate with the thyrotoxic activity of Graves' disease. (22512415)
2012
14
A 2011 survey of clinical practice patterns in the management of Graves' disease. (23043191)
2012
15
Identification of a combination of SNPs associated with Graves' disease using swarm intelligence. (21318483)
2011
16
The influence of non-radioactive iodine (127I) on the outcome of radioiodine (131I) therapy in patients with Graves' disease and toxic nodular goitre. (21751166)
2011
17
Efficiency analysis of using tailored individual doses of radioiodine and fine tuning using a low-dose antithyroid drug in the treatment of Graves' disease. (21191313)
2011
18
Fibroblasts expressing the thyrotropin receptor overarch thyroid and orbit in Graves' disease. (21956421)
2011
19
Cancer risk in patients hospitalised for Graves' disease: a population-based cohort study in Sweden. (20354521)
2010
20
Psychotic disorder as a manifestation of Graves' disease. (20833948)
2010
21
Total thyroidectomy is superior to subtotal thyroidectomy for management of Graves' disease in the United States. (20033406)
2010
22
Utility of colour Doppler sonography in patients with Graves' disease. (20583684)
2009
23
Association of polymorphism in genes encoding kappaB inhibitors (IkappaB) with susceptibility to and phenotype of Graves' disease: a case-control study. (19886988)
2009
24
Association of CTLA-4 gene polymorphism with Graves' disease and ophthalmopathy in Iranian patients. (19524188)
2009
25
Rare association of Hodgkin lymphoma, Graves' disease and myasthenia gravis complicated by post-radiation neurofibrosarcoma: coincidence or genetic susceptibility? (19381762)
2009
26
A C/T polymorphism in CD40 gene is not associated with susceptibility and phenotype of Graves' disease in Taiwanese. (18446002)
2008
27
Central nervous system vasculitis after starting methimazole in a woman with Graves' disease. (18788922)
2008
28
An alternative therapy for graves' disease: clinical effects and mechanisms of an herbal remedy. (18379045)
2008
29
The CBLB gene and Graves' disease in children. (16459459)
2005
30
No association between an interleukin 4 gene promoter (-589) polymorphism and Graves' disease in Thai patients. (16083175)
2004
31
CTLA-4 AT-repeat polymorphism reduces the inhibitory function of CTLA-4 in Graves' disease. (14751028)
2003
32
Possible induction of Graves' disease and painless thyroiditis by gonadotropin-releasing hormone analogues. (14558924)
2003
33
46, XY pure gonadal dysgenesis: a case with Graves' disease and exceptionally tall stature. (11518114)
2001
34
Coexistence of Graves' disease and struma ovarii: case report and literature review. (11456276)
2001
35
No association of an interleukin 4 gene promoter polymorphism with Graves' disease in the United Kingdom. (11502824)
2001
36
Primary role of the HLA class II DRB1*0301 allele in Graves disease. (11146462)
2000
37
Induction of experimental autoimmune Graves' disease in BALB/c mice. (10528222)
1999
38
An elevation of serum immunoglobulin E provides a new aspect of hyperthyroid Graves' disease]. (10483274)
1999
39
Increased serum concentration of interleukin-5 in patients with Graves' disease and Hashimoto's thyroiditis. (9545110)
1998
40
Lymphocytic hypophysitis in a patient with Graves' disease. (9591217)
1998
41
Graves disease associated with autoimmune thrombocytopenic purpura. (9140276)
1997
42
Incomplete thyrotroph suppression determined by third generation thyrotropin assay in subacute thyroiditis compared to silent thyroiditis or hyperthyroid Graves' disease. (9024264)
1997
43
Cardiomyopathy associated with Graves' disease. (8796147)
1996
44
Serum levels of the carboxy-terminal cross-linked telopeptide of type I collagen and laminin are elevated in Graves' disease but not in toxic nodular goiter. (7768039)
1995
45
Clinical evaluations of subtotal thyroidectomy for Graves' disease]. (7895863)
1995
46
Analysis of circulating thyroid-stimulating activities in pregnant women with Graves' disease: differential measurement of activities induced by TSH receptor antibody and hCG]. (1434029)
1992
47
Changes in serum thyroglobulin and thyroid autoantibodies in patients with Graves' disease treated with antithyroid drug and their relationship to relapse. (1724781)
1991
48
"Osler's sign": pretibial myxedema of Graves' disease. (3884118)
1985
49
Thymic hyperplasia in Graves' disease. (4099281)
1971
50
The history of the use of iodine in toxic diffuse goiter (Graves' disease). (13457495)
1957

Genetic Variations for Graves' Disease

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Expression for genes affiliated with Graves' Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Graves' Disease

Search GEO for disease gene expression data for Graves' Disease.

Pathways for genes affiliated with Graves' Disease

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29KEGG, 51QIAGEN, 53Reactome
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Compounds for genes affiliated with Graves' Disease

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44Novoseek, 24HMDB, 2BitterDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Graves' Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1tyrosine4412.0TSHR, PTPN22, CD80, IL13, CYP27B1, LMOD1
2cysteine4411.9TG, CD40, DIO2, TSHR, CTLA4, CT49
3estrogen4411.7IL13, TG, CTLA4, DIO2, CYP27B1, CT49
4retinoic acid44 2412.7CT49, DIO2, CD40, CYP27B1, IL13, TSHR
5oligonucleotide4411.6TSHR, CD40, CT49, HLA-DQA1, TPO, CYP27B1
6iodine44 2412.5TSHR, CTLA4, DIO2, LMOD1, TPO, TG
7thyroxine44 2412.5TG, TPO, LMOD1, IL13, DIO2, TSHR
8paraffin4411.5CYP27B1, CT49, HLA-DQA1, CD40, TSHR, TG
9thymidine44 2412.5CD40, IL13, CT49, TG, TSHR, CTLA4
10125i4411.4TSHR, TPO, TG, DIO2, LMOD1
11iodide44 2412.4LMOD1, DIO2, TSHR, TPO, TG
12methimazole44 2 1113.4IL13, TG, TPO, TSHR, DIO2
13triiodothyronine4411.4TG, DIO2, TPO, LMOD1, TSHR
14steroid4411.4CYP27B1, CTLA4, CT49, IL13, TPO, CD40
15mannose4411.4TSHR, IL13, CD80, CD40, TG
16ionomycin4411.4CD40, IL13, TSHR, CTLA4, CD80
17ribonucleic acid4411.4TSHR, TPO, TG, CD40, DIO2
18arginine4411.3PTPN22, HLA-DQA1, IL13, TPO, TSHR, TG
19alanine4411.3TG, DIO2, CTLA4, TSHR, CT49, IL13
20dexamethasone44 49 28 1114.3CTLA4, DIO2, CD80, LMOD1, IL13
21cyclosporin a44 28 5913.3CTLA4, CD40, CD80, IL13, TG
22rituximab44 49 1113.3IL13, CD40, CTLA4, CD80
23allergens4411.3CD80, IL13, CD40, CTLA4
24dithiothreitol4411.3DIO2, TPO, CD40, LMOD1
25prednisolone44 28 1113.2TG, TSHR, CD40, IL13
26sodium iodide4411.2TPO, TG, TSHR
27amiodarone44 49 28 1114.1TPO, LMOD1, TG
28propylthiouracil44 2 1113.1TG, DIO2
29chloramphenicol44 2 1113.1TSHR, CD40, IL13, CYP27B1
30forskolin44 49 1113.1TSHR, CT49
31glutamate4411.1PTPN22, TPO
32il 104411.1CD40, IL13, CTLA4
33n-bromoacetyl-3,3,5-triiodo-l-thyronine4411.0DIO2, LMOD1
34iodotyrosine44 2412.0TG, TPO
35adenylate4411.0CD40, TPO, IL13, TSHR, TG
36hydrocortisone44 2 59 1114.0TPO, TG
37diiodotyrosine4411.0TPO, TG
38selenium44 2412.0TG, DIO2, TPO
39belatacept44 1112.0CD80, CTLA4
40cycloheximide4411.0DIO2
413,3-diiodothyronine4411.0LMOD1, DIO2
42serine4411.0TSHR, IL13, DIO2, CT49, CTLA4
43abatacept44 1112.0CD80, CTLA4
44aspartate4410.9TPO, TG
45polysaccharide4410.9TG, TSHR, TPO, IL13
46carbimazole44 1111.9TSHR, TPO
47ctla4-ig4410.8CTLA4, CD80
48perchlorate4410.8TG, TPO
49acetylcholine44 49 28 11 2414.8CTLA4, IL13, TPO, TG
50cholesterol44 28 11 2413.7CTLA4, CD40, CYP27B1, TSHR, TPO

GO Terms for genes affiliated with Graves' Disease

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16Gene Ontology
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Cellular components related to Graves' Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.9IL13, CD80, CD40, CTLA4

Biological processes related to Graves' Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1T cell costimulationGO:03129510.8CD80, HLA-DQA1, CTLA4
2hormone biosynthetic processGO:04244610.7TG, TPO, DIO2
3thyroid hormone generationGO:00659010.5TG, TPO, DIO2

Products for genes affiliated with Graves' Disease

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  • Antibodies
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Sources for Graves' Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet