MCID: GRV001
MIFTS: 54

Graves' Disease malady

Rare diseases, Endocrine diseases categories

Aliases & Classifications for Graves' Disease

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Graves' Disease, Aliases & Descriptions:

Name: Graves' Disease 9 41 21
Graves Disease 9 21 11 43 60
Exophthalmic Goiter 9 41 21
Toxic Diffuse Goiter 21 60
Grave's Disease 9 22
Basedow Disease 41 21
 
Autoimmune Hyperthyroidism 21
Toxic Multinodular Goiter 60
Graves' Hyperthyroidism 41
Basedow's Disease 21
Parry Disease 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Endocrine diseases


Summaries for Graves' Disease

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NIH Rare Diseases:41 Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism). it is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. graves disease is the most common cause of hyperthyroidism and occurs most often in women over age 20. however, the disorder may occur at any age and may affect males as well. treatment may include radioiodine therapy, antithyroid drugs, and/or thyroid surgery. last updated: 5/11/2010

MalaCards based summary: Graves' Disease, also known as graves disease, is related to thyroiditis and myxedema. An important gene associated with Graves' Disease is CTLA4 (cytotoxic T-lymphocyte-associated protein 4), and among its related pathways are Metabolism of steroid hormones and vitamin D and Vitamin D synthesis. The compounds iodotyrosine and diiodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include thyroid gl, thyroid and eye, and related mouse phenotypes are skeleton and immune system.

Disease Ontology:9 An autoimmune disease of endocrine system that involves production of excessive amount of thyroid hormones, located in thyroid gland.

Genetics Home Reference:21 Graves disease is a condition that affects the function of the thyroid, which is a butterfly-shaped gland in the lower neck. The thyroid makes hormones that help regulate a wide variety of critical body functions. For example, thyroid hormones influence growth and development, body temperature, heart rate, menstrual cycles, and weight. In people with Graves disease, the thyroid is overactive and makes more hormones than the body needs. The condition usually appears in mid-adulthood, although it may occur at any age.

Wikipedia:63 Graves\' disease (or Flajani-Basedow-Graves disease) is an autoimmune disease. It most commonly affects... more...

Related Diseases for Graves' Disease

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Diseases related to Graves' Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 235)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.7PTPN22, TPO, TG, TSHR, CTLA4
2myxedema31.2TPO, TG, TSHR
3thyrotoxicosis31.2TPO, TG, TSHR
4struma ovarii31.2TG, TSHR
5hypothyroidism31.1TPO, TG, TSHR
6goiter31.1DIO2, TSHR, LMOD1, TG, TPO
7subacute thyroiditis31.1TSHR, TG, TPO
8multinodular goiter31.0TSHR, TG, TPO
9autoimmune thyroiditis31.0TG, TPO
10thyroid cancer30.9TPO, TG, TSHR
11thyroid adenoma30.7DIO2, TSHR, TG, TPO
12nontoxic goiter30.6TSHR, TG, TPO
13pernicious anemia30.5TPO, TG
14adenoma30.5TPO, TG, LMOD1, TSHR, DIO2, CTLA4
15papillary carcinoma30.5TPO, TG, TSHR
16hyperthyroidism30.4PTPN22, IGES, TPO, TG, LMOD1, TSHR
17nodular goiter30.4TNFRSF4, TPO, TG, TSHR, CTLA4
18toxic diffuse goiter30.4TPO, TG, TSHR
19congenital hypothyroidism30.3TSHR, TG, TPO
20addison's disease30.3CYP27B1, PTPN22, TPO, TG, CTLA4
21plummer's disease30.3TPO, TG
22connective tissue disease30.2PTPN22, CD40, CTLA4
23turner syndrome30.2TG, TPO
24hyperthyroxinemia30.2TPO, TSHR
25celiac disease30.1PTPN22, TPO, TG, CTLA4
26osteoporosis30.0GC, CYP27B1
27t-cell leukemia29.6TNFRSF4, HTLVR, CD40
28rheumatoid arthritis29.4CYP27B1, TNFRSF4, PTPN22, HTLVR, CD40, CTLA4
29systemic lupus erythematosus29.4TNFRSF4, PTPN22, TPO, TSHR, CD40, CTLA4
30melanoma29.1CYP27B1, TNFRSF4, TSHR, CD40, CTLA4
31hashimoto thyroiditis29.0CTLA4, CD40, TSHR, LMOD1, TG, TPO
32leukemia28.9CYP27B1, TNFRSF4, TSHR, HTLVR, CD40
33exophthalmos10.6
34thymic hyperplasia10.6
35wegener granulomatosis10.5CTLA4
36hepatitis10.4
37mediastinitis10.4
38steroid-induced glaucoma10.4FGFR1OP, LMOD1
39hypothyroidism, congenital, due to thyroid dysgenesis or hypoplasia10.4TSHR, TG
40thyrotoxic periodic paralysis10.4
41insulin autoimmune syndrome10.3
42thyroid carcinoma, follicular10.3TSHR, TG
43pendred syndrome10.3TG, TPO
44goiter, multinodular 1, with or without sertoli-leydig cell tumors10.3TPO, TG
45myasthenia gravis10.3
46pancytopenia10.3
47factor vii deficiency10.3CTLA4, TG
48hypothryoidism, congenital, nongoitrous 410.3TG, TPO
49arthritis10.3
50hepatitis c10.3

Graphical network of the top 20 diseases related to Graves' Disease:



Diseases related to graves' disease

Symptoms for Graves' Disease

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Drugs & Therapeutics for Graves' Disease

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Drug clinical trials:

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Search NIH Clinical Center for Graves' Disease

Genetic Tests for Graves' Disease

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Genetic tests related to Graves' Disease:

id Genetic test Affiliating Genes
1 Graves' Disease22

Anatomical Context for Graves' Disease

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MalaCards organs/tissues related to Graves' Disease:

31
Thyroid, Eye, Heart, T cells, Skin, Bone, B cells, Testes, Breast, Endothelial, Thymus, Liver, Pituitary, Skeletal muscle, Ovary, Neutrophil, Bone marrow, Lymph node, Brain, Monocytes, Nk cells

FMA organs/tissues related to Graves' Disease:

14
Thyroid gl

Animal Models for Graves' Disease or affiliated genes

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MGI Mouse Phenotypes related to Graves' Disease:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.7CYP27B1, TPO, DIO2, GC, CD40, CTLA4
2MP:00053878.7TNFRSF4, PTPN22, TPO, TSHR, CD40, CTLA4
3MP:00053798.7CTLA4, CYP27B1, PTPN22, TPO, TG, TSHR
4MP:00053978.4CYP27B1, TNFRSF4, PTPN22, TPO, TG, TSHR
5MP:00053767.8CYP27B1, PTPN22, DBP, TPO, TG, TSHR

Publications for Graves' Disease

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Articles related to Graves' Disease:

(show top 50)    (show all 1332)
idTitleAuthorsYear
1
Radioiodine therapy in patients with Graves' disease and the effects of prior carbimazole therapy. (25285287)
2014
2
Left-shifted relation between calcium and parathyroid hormone in Graves' Disease. (24248181)
2013
3
Maximinus Daia, a Roman emperor who may have had Graves' disease and died of a thyrotoxic crisis. (23624140)
2013
4
Anaplastic thyroid carcinoma following radioactive iodine therapy for graves' disease. (24396653)
2013
5
The negative correlation between thyrotropin receptor-stimulating antibodies and bone mineral density in postmenopausal patients with Graves' disease. (23612147)
2013
6
Unexpected conversion from hypothyroidism to an euthyroid state due to Graves' disease in a patient with an ectopic thyroid. (24282039)
2013
7
Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis. (23612905)
2013
8
Mental health status and factors that influence the course of Graves' disease and antithyroid treatments. (23070829)
2012
9
Graves' disease in two pregnancies complicated by fetal goitrous hypothyroidism: successful in utero treatment with levothyroxine. (21162688)
2011
10
Thymic Hyperplasia Associated with Graves' Disease in a 10-year-old Boy. (23926397)
2011
11
Graves' disease. When thyroid hormones run wild. (21200368)
2011
12
Serum chemokine (C-X-C motif ) ligand 10 levels are elevated in patients with Graves' disease in long-term remission. (20144041)
2010
13
Association analysis of polymorphisms in IL-3, IL-4, IL-5, IL-9, and IL-13 with Graves' disease. (20332709)
2010
14
Cancer risk in patients hospitalised for Graves' disease: a population-based cohort study in Sweden. (20354521)
2010
15
The interleukin-1 family gene polymorphisms and Graves' disease. (20400062)
2010
16
Thyroid stimulating hormone receptor (TSHR) intron 1 variants are major risk factors for Graves' disease in three European Caucasian cohorts. (21124799)
2010
17
Somatostatin receptor 2 expression determined by immunohistochemistry in cold thyroid nodules exceeds that of hot thyroid nodules, papillary thyroid carcinoma, and Graves' disease. (20450431)
2010
18
Resistance to thyroid hormone in a patient with coexisting Graves' disease. (20151830)
2010
19
Clinical features of primary hyperthyroidism caused by Graves' disease admixed with resistance to thyroid hormone (P453T). (20574139)
2010
20
Familial risks for hospitalized Graves' disease and goiter. (19661127)
2009
21
Angiogenic study in Graves' disease treated with thyroid arterial embolization. (19796574)
2009
22
Severe ophthalmopathy developing after treatment of coexisting malignant struma ovarii and Graves' disease. (19772400)
2009
23
High iodine (substrate) turnover Graves' disease: the intriguing 'rapid responder' variant of thyrotoxicosis. (18941129)
2008
24
Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. (18449200)
2008
25
Association of tumour necrosis factor alpha (TNF-alpha) polymorphisms with Graves' disease: A meta-analysis. (18472000)
2008
26
B cells from patients with Graves' disease aberrantly express the IGF-1 receptor: implications for disease pathogenesis. (18832736)
2008
27
The adaptation and relationship of FGF-23 to changes in mineral metabolism in Graves' disease. (17437520)
2007
28
Correlation between serum osteoprotegerin and biomarkers of bone metabolism during anti-thyroid treatment in patients with Graves' disease. (16912510)
2006
29
Elephantiasis Nostras Verrucosa: a rare thyroid dermopathy in Graves' disease. (16121817)
2005
30
A haplotype of the CYP27B1 promoter is associated with autoimmune Addison's disease but not with Graves' disease in a UK population. (15956353)
2005
31
Pretibial myxedema, ophthalmopathy and acropachy in a male patient with Graves' disease. (17642674)
2004
32
Reversible mitral valve prolapse and mitral regurgitation in children with Graves' disease. (15506680)
2004
33
Dermopathy of Graves' disease (pretibial myxedema): long-term outcome. (11836263)
2002
34
Frequency of appearance of myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) in Graves' disease patients treated with propylthiouracil and the relationship between MPO-ANCA and clinical manifestations. (11380496)
2001
35
Elephantiasic pretibial myxedema: insight into and a hypothesis regarding the pathogenesis of the extrathyroidal manifestations of Graves' disease. (11014313)
2000
36
An elevation of serum immunoglobulin E provides a new aspect of hyperthyroid Graves' disease. (10946880)
2000
37
Thyroid-associated ophthalmopathy in black South African patients with Graves' disease: relationship to antiflavoprotein antibodies. (9848717)
1998
38
Increased serum concentration of interleukin-5 in patients with Graves' disease and Hashimoto's thyroiditis. (9545110)
1998
39
CTLA4 gene polymorphism confers susceptibility to Graves' disease in Japanese. (9459626)
1997
40
CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus. (8989248)
1997
41
Expression of membrane and soluble intercellular adhesion molecule-1 in Graves' disease. (9343311)
1997
42
Binding of antithyrotropin receptor autoantibodies in Graves' disease serum to nascent, in vitro translated thyrotropin receptor: ability to map epitopes recognized by antibodies. (8636291)
1996
43
Systemic scleroderma associated with Graves' disease. (9037923)
1996
44
CD31, CD62E, and CD62P identify a specific pattern of endothelial activation in Graves' disease. (7542186)
1995
45
Identification of thyroid stimulating hormone receptor-specific T cells in Graves' disease thyroid using autoantigen-transfected Epstein-Barr virus-transformed B cell lines. (7615799)
1995
46
A case of pretibial myxedema associated with Graves' disease: an immunohistochemical study of serum-derived hyaluronan-associated protein. (8648004)
1995
47
Soluble intercellular adhesion molecule-1 (sICAM-1) in Graves' disease. (7866729)
1994
48
Dynamic changes in soluble interleukin-2 receptor levels during treatment of Graves' disease. Correlation with disease activity. (1916654)
1991
49
Association of HLA antigen and restriction fragment length polymorphism of T cell receptor beta-chain gene with Graves' disease and Hashimoto's thyroiditis. (2567295)
1989
50
Ultrastructural and immunological findings in Graves' disease with pretibial myxedema. (6989863)
1980

Variations for Graves' Disease

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Expression for genes affiliated with Graves' Disease

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Search GEO for disease gene expression data for Graves' Disease.

Pathways for genes affiliated with Graves' Disease

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Compounds for genes affiliated with Graves' Disease

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Compounds related to Graves' Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1iodotyrosine43 2411.4TPO, TG
2diiodotyrosine4310.4TG, TPO
3perchlorate4310.3TG, TPO
4n-bromoacetyl-3,3,5-triiodo-l-thyronine4310.3LMOD1, DIO2
53,3-diiodothyronine4310.3LMOD1, DIO2
6alfacalcidol43 59 1212.3GC, CYP27B1
7carbimazole43 1211.3TSHR, TPO
8sodium iodide4310.2TPO, TG, TSHR
9selenium43 2411.1DIO2, TG, TPO
10amiodarone43 49 28 1213.1LMOD1, TG, TPO
11amino acid4310.0TSHR, TPO
12prednisolone43 28 1212.0CD40, TSHR, TG
13liothyronine49 24 1212.0DIO2, TPO
14methimazole43 2 1212.0TPO, TG, TSHR, DIO2
15sialic acid4310.0TG, TSHR, GC
16hydrocortisone43 2 59 1212.9CD40, TG, TPO
17ionomycin439.9TNFRSF4, TSHR, CD40, CTLA4
18chloramphenicol43 2 49 1212.8CD40, GC, TSHR, CYP27B1
19dithiothreitol439.8TPO, LMOD1, DIO2, CD40
20paraffin439.8CD40, TSHR, TG, CYP27B1
21ribonucleic acid439.7TPO, TG, TSHR, DIO2, CD40
22gliadin439.7TG, TPO
23genistein43 28 59 2 24 1214.7CYP27B1, TPO, TG, CD40
24propylthiouracil43 2 1211.7TPO, TG, LMOD1, TSHR, DIO2
25125i439.7TPO, TG, LMOD1, TSHR, DIO2
26iodide43 2410.7TPO, TG, LMOD1, TSHR, DIO2
27triiodothyronine439.6TPO, TG, LMOD1, TSHR, DIO2
28adenylate439.6TPO, TG, TSHR, GC, CD40
29forskolin43 49 1211.6CYP27B1, TPO, TSHR, DIO2, CD40
30cycloheximide439.6CYP27B1, TPO, TG, DIO2, CD40
31threonine439.6TSHR, DIO2, GC, CD40, CTLA4
32lysine439.6CYP27B1, TPO, TSHR, CTLA4
33hydrogen43 2410.6CD40, TSHR, TPO, CYP27B1
34thymidine43 2410.6CTLA4, CD40, TSHR, TG
35allergens439.5IGES, CD40, CTLA4
36iodine43 2410.5CTLA4, DIO2, TSHR, LMOD1, TG, TPO
37thyroxine43 2410.4TPO, TG, LMOD1, TSHR, DIO2, GC
38glucose439.4CYP27B1, TSHR, DIO2, GC, CD40, CTLA4
39cholesterol43 28 24 1212.4CYP27B1, TPO, TSHR, GC, CD40, CTLA4
40lipid439.3CYP27B1, TPO, TSHR, GC, CD40, CTLA4
41glutamate439.3PTPN22, TPO, TG, TSHR, GC, CD40
42acetylcholine43 49 28 24 1213.3IGES, TPO, TG, CTLA4
43retinoic acid43 2410.2CYP27B1, TPO, TG, TSHR, DIO2, GC
44estrogen439.2CYP27B1, TG, LMOD1, TSHR, DIO2, GC
45oligonucleotide439.1CYP27B1, TPO, TSHR, HTLVR, CD40
46cyclosporin a43 28 5911.1CTLA4, CD40, TG, TNFRSF4, IGES
47cysteine438.9CYP27B1, TPO, TG, LMOD1, TSHR, DIO2
48steroid438.8IGES, CYP27B1, TPO, GC, CD40, CTLA4
49calcium43 49 24 1211.7CYP27B1, TPO, TSHR, DIO2, GC, CD40
50tyrosine438.7CYP27B1, PTPN22, TPO, TG, LMOD1, TSHR

GO Terms for genes affiliated with Graves' Disease

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Cellular components related to Graves' Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.4CTLA4, CD40, TNFRSF4
2integral component of plasma membraneGO:00058879.2CTLA4, CD40, TSHR, TPO, TNFRSF4

Biological processes related to Graves' Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell proliferationGO:00308909.9TNFRSF4, CD40
2hormone biosynthetic processGO:00424469.8TPO, TG, DIO2
3thyroid hormone generationGO:00065909.7DIO2, TPO, TG
4vitamin D metabolic processGO:00423599.7CYP27B1, GC

Products for genes affiliated with Graves' Disease

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Sources for Graves' Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet