MCID: GRV001
MIFTS: 63

Graves' Disease malady

Summaries for Graves' Disease

Sources:
8Disease Ontology, 21Genetics Home Reference, 43NIH Rare Diseases, 64Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism). it is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. graves disease is the most common cause of hyperthyroidism and occurs most often in women over age 20. however, the disorder may occur at any age and may affect males as well. treatment may include radioiodine therapy, antithyroid drugs, and/or thyroid surgery. last updated: 5/11/2010

MalaCards: Graves' Disease, also known as graves disease, is related to thyroiditis and myxedema. An important gene associated with Graves' Disease is CTLA4 (cytotoxic T-lymphocyte-associated protein 4), and among its related pathways are Allograft rejection and CD28 co-stimulation. The compounds tyrosine and cysteine have been mentioned in the context of this disorder. Affiliated tissues include thyroid gl, skin and ovary, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 An autoimmune disease of endocrine system that involves production of excessive amount of thyroid hormones, located in thyroid gland.

Genetics Home Reference:21 Graves disease is a condition that affects the function of the thyroid, which is a butterfly-shaped gland in the lower neck. The thyroid makes hormones that help regulate a wide variety of critical body functions. For example, thyroid hormones influence growth and development, body temperature, heart rate, menstrual cycles, and weight. In people with Graves disease, the thyroid is overactive and makes more hormones than the body needs. The condition usually appears in mid-adulthood, although it may occur at any age.

Wikipedia:64 Graves\' disease (or Basedow-Graves disease) is an autoimmune disease. It most commonly affects the... more...

Description from OMIM:47 275000

Aliases & Classifications for Graves' Disease

Sources:
8Disease Ontology, 43NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 10DISEASES, 45Novoseek, 61UMLS, 47OMIM, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Aliases & Descriptions:

graves' disease 8 43 21
graves disease 8 22 21 10 45 61
exophthalmic goiter 8 43 21
toxic diffuse goiter 21 61
basedow disease 43 21
toxic diffuse goiter with exophthalmos 8
autoimmune hyperthyroidism 21
toxic multinodular goiter 61
graves' hyperthyroidism 43
basedow's disease 21
grave's disease 8
parry disease 43


Related Diseases for Graves' Disease

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Graves' Disease family:

graves disease 4 graves disease 3
graves disease 1 graves disease 2

Diseases related to Graves' Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 247)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.3CTLA4, PTPN22, TSHR, TPO, TG
2myxedema31.0TG, TPO, TSHR
3thyrotoxicosis30.9TSHR, TPO, TG
4subacute thyroiditis30.8TSHR, TPO, TG
5nodular goiter30.8TG, TPO, TSHR, CD80, CTLA4
6multinodular goiter30.8TG, TPO, TSHR
7thyroid cancer30.8TG, TPO, TSHR
8adenoma30.7TG, CT49, CTLA4, DIO2, LMOD1, TSHR
9papillary carcinoma30.6TG, TPO, TSHR
10struma ovarii30.6TSHR, TG
11thyroid adenoma30.6DIO2, TSHR, TPO, TG
12autoimmune thyroiditis30.6TPO, TG
13hepatitis c30.6TSHR, CTLA4, PSMB9
14nontoxic goiter30.5TSHR, TPO, TG
15arthritis30.4PSMB9, CTLA4, CD80, IL13, PTPN22
16endemic goiter30.4TSHR, TPO, TG
17vitiligo30.3CTLA4, PTPN22, TPO
18hypoparathyroidism30.3CTLA4
19addison's disease30.3CTLA4, CYP27B1, PTPN22, TPO, TG
20vasculitis30.3CTLA4, CD80
21type 1 diabetes30.1HTLVR, PSMB9, CTLA4, HLA-DQA1, CYP27B1, PTPN22
22adenocarcinoma30.1CYP27B1, CD80, DIO2, CT49
23systemic lupus erythematosus30.1CTLA4, HLA-DQA1, CD40, CD80, PTPN22, TSHR
24toxic diffuse goiter30.1TSHR, TPO, TG
25congenital hypothyroidism30.1TSHR, TPO, TG
26pernicious anemia30.1TPO, TG
27celiac disease29.9CTLA4, HLA-DQA1, PTPN22, TPO, TG
28systemic scleroderma29.9CTLA4, CD80, IL13, PTPN22
29uveitis29.9CTLA4
30plummer's disease29.9TPO, TG
31thyroid agenesis29.9TSHR, TG
32diabetic ketoacidosis29.9CTLA4
33thymoma29.9CTLA4
34allergic rhinitis29.9IL13, CTLA4
35hyperthyroxinemia29.9TPO, TSHR
36exophthalmos10.6
37graves disease 110.6
38thymic hyperplasia10.6
39graves disease 210.5
40thyroid gland disease10.5
41hepatitis d10.4
42thyrotoxic periodic paralysis10.4
43moyamoya disease10.3
44hepatitis a10.3
45insulin autoimmune syndrome10.3
46pancytopenia10.3
47hypokalemic periodic paralysis10.3
48bone carcinoma10.3
49thyroid hormone resistance, selective pituitary10.3
50thyroid lymphoma10.2

Graphical network of the top 20 diseases related to Graves' Disease:



Diseases related to graves' disease

Clinical Features for Graves' Disease

Sources:
47OMIM
See all sources

Clinical features from OMIM:

275000

Drugs & Therapeutics for Graves' Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Graves' Disease

Drug clinical trials:

Search ClinicalTrials for Graves' Disease

Search NIH Clinical Center for Graves' Disease

Search CenterWatch for Graves' Disease

Genetic Tests for Graves' Disease

Sources:
22GTR
See all sources

Genetic tests related to Graves' Disease:

id Genetic test Affiliating Genes
1 Graves' Disease22

Anatomical Context for Graves' Disease

Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Graves' Disease:

33
Skin, Ovary, Liver, Brain, Lymph node, Bone marrow, Whole blood, Thymus, Heart, Skeletal muscle, Thyroid, Adrenal gland, Breast, Monocytes, T cells, B cells, Endothelial, Fetal brain, Temporal lobe, Fetal liver, Fetal thyroid, Pituitary

FMA organs/tissues related to Graves' Disease:

14
Thyroid gl

Animal Models for Graves' Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Graves' Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539711.5TG, PSMB9, CTLA4, HLA-DQA1, CD40, CD80
2MP:000538711.2CD40, HLA-DQA1, CTLA4, PSMB9, CD80, CYP27B1
3MP:000537910.9TG, TSHR, CYP27B1, CD80

Publications for Graves' Disease

Sources:
51PubMed
See all sources

Articles related to Graves' Disease:

(show top 50)    (show all 1329)
idTitleAuthorsYear
1
Graves' disease as immune reconstitution disease in HIV-positive patients is associated with naive and primary thymic emigrant CD4+ T-cell recovery. (23939238)
2014
2
The negative correlation between thyrotropin receptor-stimulating antibodies and bone mineral density in postmenopausal patients with Graves' disease. (23612147)
2013
3
Carbimazole-induced cholestatic hepatitis in Graves' disease. (23776913)
2013
4
Thyrotoxic periodic paralysis with Graves' disease leading to the discovery of a hidden nonclassic 11I^ hydroxylase deficiency. (23291679)
2013
5
Unilateral gynecomastia and hypokalemic periodic paralysis as first manifestations of Graves' disease. (23276903)
2013
6
Unusual problems in the management of hyperthyroid Graves' disease. (23435045)
2013
7
Insulin autoimmune syndrome induced by methimazole in a patient with Graves' disease. (23817229)
2013
8
Involvement of inducible costimulator ligand (ICOSL) expression in thyroid tissue in hyperthyroidism of Graves' disease patients. (22706735)
2012
9
An attempt to induce "Graves' disease of the gonads" by immunizing mice with the luteinizing hormone receptor provides insight into breaking tolerance to self-antigens. (21649471)
2011
10
The influence of non-radioactive iodine (127I) on the outcome of radioiodine (131I) therapy in patients with Graves' disease and toxic nodular goitre. (21751166)
2011
11
Efficiency analysis of using tailored individual doses of radioiodine and fine tuning using a low-dose antithyroid drug in the treatment of Graves' disease. (21191313)
2011
12
Fibroblasts expressing the thyrotropin receptor overarch thyroid and orbit in Graves' disease. (21956421)
2011
13
Observing pretibial myxedema in patients with Graves' disease using digital infrared thermal imaging and high-resolution ultrasonography: for better records, early detection, and further investigation. (21266550)
2011
14
Optimizing remission rates using antithyroid drugs for Graves' disease. (20050856)
2010
15
Psychotic disorder as a manifestation of Graves' disease. (20833948)
2010
16
Graves' disease in a Down's syndrome patient. (21284333)
2010
17
Impact of lithium on efficacy of radioactive iodine therapy for Graves' disease: a cohort study on cure rate, time to cure, and frequency of increased serum thyroxine after antithyroid drug withdrawal. (19906789)
2010
18
Confirmation of association of chromosome 5q31-33 with United Kingdom Caucasian Graves' disease. (20210668)
2010
19
Recurrence of Graves' disease in thyroglossal duct remnants: relapse after total thyroidectomy. (19916864)
2009
20
Association of polymorphism in genes encoding kappaB inhibitors (IkappaB) with susceptibility to and phenotype of Graves' disease: a case-control study. (19886988)
2009
21
Association of CTLA-4 gene polymorphism with Graves' disease and ophthalmopathy in Iranian patients. (19524188)
2009
22
Gray-scale and color Doppler sonographic findings in a case of mesenteric Castleman's disease incidentally detected in a patient with Graves' disease. (16196012)
2005
23
A case of bilateral breast cancer and Graves' disease. (15656338)
2004
24
Exon-1 polymorphism of ctla-4 gene in Iranian patients with Graves' disease. (14567561)
2003
25
CTLA-4 AT-repeat polymorphism reduces the inhibitory function of CTLA-4 in Graves' disease. (14751028)
2003
26
Possible induction of Graves' disease and painless thyroiditis by gonadotropin-releasing hormone analogues. (14558924)
2003
27
No association of an interleukin 4 gene promoter polymorphism with Graves' disease in the United Kingdom. (11502824)
2001
28
Association of polymorphism of LTalpha and TNF genes with Graves' disease. (11820636)
2001
29
Elephantiasic pretibial myxedema: insight into and a hypothesis regarding the pathogenesis of the extrathyroidal manifestations of Graves' disease. (11014313)
2000
30
Serum cytokines levels in Graves' disease. (11500727)
2000
31
Primary role of the HLA class II DRB1*0301 allele in Graves disease. (11146462)
2000
32
Cytokins and adhesion molecules in Graves's disease]. (12818079)
2000
33
A case of Graves' disease associated with autoimmune hepatitis and mixed connective tissue disease. (10426583)
1999
34
Relapsing polychondritis developing in a patient with Graves' disease: a possible association with propylthiouracil]. (11185689)
1999
35
An elevation of serum immunoglobulin E provides a new aspect of hyperthyroid Graves' disease]. (10483274)
1999
36
Effect of radioactive iodine therapy on cytokine production in Graves' disease: transient increases in interleukin-4 (IL-4), IL-6, IL-10, and tumor necrosis factor-alpha, with longer term increases in interferon-gamma production. (10566657)
1999
37
Two Graves' disease patients who spontaneously developed hypothyroidism after antithyroid drug treatment: characteristics of epitopes for thyrotropin receptor antibodies. (10319947)
1999
38
Correlation between clubbing and exophthalmos and/or pretibial myxoedema in Graves disease. (10778547)
1999
39
Lymphocytic hypophysitis in a patient with Graves' disease. (9591217)
1998
40
CTLA4 gene polymorphism confers susceptibility to Graves' disease in Japanese. (9459626)
1997
41
Coexpression of CD40 and class II antigen HLA-DR in Graves' disease thyroid epithelial cells. (9245555)
1997
42
Incomplete thyrotroph suppression determined by third generation thyrotropin assay in subacute thyroiditis compared to silent thyroiditis or hyperthyroid Graves' disease. (9024264)
1997
43
Graves' disease and autoimmune factor VIII deficiency. (8837334)
1996
44
Antibodies to acetylcholinesterase cross-reacting with thyroglobulin in myasthenia gravis and Graves's disease. (7743674)
1995
45
HLA-DQB1-associated susceptibility that distinguishes Hashimoto's thyroiditis from Graves' disease in type I diabetic patients. (8157715)
1994
46
Expression of the Hermes-1 (CD44) and ICAM-1 (CD54) molecule on the surface of thyroid cells from patients with Graves' disease. (7509669)
1993
47
Implication of the HLA-DRB3 gene in Graves' disease: predominance of allele Dw24. (1979072)
1990
48
"Osler's sign": pretibial myxedema of Graves' disease. (3884118)
1985
49
Thymic hyperplasia in Graves' disease. (4099281)
1971
50
The history of the use of iodine in toxic diffuse goiter (Graves' disease). (13457495)
1957

Genetic Variations for Graves' Disease

Expression for genes affiliated with Graves' Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Graves' Disease

Search GEO for disease gene expression data for Graves' Disease.

Pathways for genes affiliated with Graves' Disease

Sources:
30KEGG, 52QIAGEN, 54Reactome
See all sources

Compounds for genes affiliated with Graves' Disease

Sources:
45Novoseek, 24HMDB, 2BitterDB, 11DrugBank, 50PharmGKB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Graves' Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1tyrosine4512.0CTLA4, DIO2, CD40, CD80, CYP27B1, IL13
2cysteine4511.9CT49, CTLA4, DIO2, CD40, CYP27B1, IL13
3estrogen4511.7CT49, CTLA4, DIO2, CYP27B1, IL13, LMOD1
4retinoic acid45 2412.7CT49, DIO2, CD40, CYP27B1, IL13, TSHR
5oligonucleotide4511.6HTLVR, CT49, HLA-DQA1, CD40, CYP27B1, TSHR
6iodine45 2412.5TG, TPO, TSHR, LMOD1, DIO2, CTLA4
7thyroxine45 2412.5DIO2, IL13, LMOD1, TSHR, TPO, TG
8paraffin4511.5CT49, HLA-DQA1, CD40, CYP27B1, TSHR, TG
9thymidine45 2412.5CT49, CTLA4, CD40, IL13, TSHR, TG
10125i4511.4TG, TPO, TSHR, LMOD1, DIO2
11iodide45 2412.4DIO2, LMOD1, TSHR, TPO, TG
12methimazole45 2 1113.4DIO2, IL13, TSHR, TPO, TG
13triiodothyronine4511.4DIO2, LMOD1, TSHR, TPO, TG
14steroid4511.4CT49, CTLA4, CD40, CYP27B1, IL13, TPO
15mannose4511.4CD40, CD80, IL13, TSHR, TG
16ionomycin4511.4CTLA4, CD40, CD80, IL13, TSHR
17ribonucleic acid4511.4DIO2, CD40, TSHR, TPO, TG
18arginine4511.3HLA-DQA1, IL13, PTPN22, TSHR, TPO, TG
19alanine4511.3CT49, CTLA4, DIO2, IL13, TSHR, TG
20dexamethasone45 50 29 1114.3CTLA4, DIO2, CD80, IL13, LMOD1
21cyclosporin a45 29 6013.3TG, IL13, CD80, CD40, CTLA4
22rituximab45 50 1113.3IL13, CD80, CD40, CTLA4
23allergens4511.3CTLA4, CD40, CD80, IL13
24dithiothreitol4511.3DIO2, CD40, LMOD1, TPO
25prednisolone45 29 1113.2CD40, IL13, TSHR, TG
26sodium iodide4511.2TSHR, TPO, TG
27amiodarone45 50 29 1114.1TG, TPO, LMOD1
28propylthiouracil45 2 1113.1DIO2, TG
29chloramphenicol45 2 1113.1CD40, CYP27B1, IL13, TSHR
30forskolin45 50 1113.1CT49, TSHR
31glutamate4511.1TPO, PTPN22
32il 104511.1IL13, CD40, CTLA4
33iodotyrosine45 2412.1TG, TPO
34adenylate4511.0CD40, IL13, TSHR, TPO, TG
35n-bromoacetyl-3,3,5-triiodo-l-thyronine4511.0LMOD1, DIO2
36hydrocortisone45 2 60 1114.0TG, TPO
37selenium45 2412.0TG, TPO, DIO2
38belatacept45 1112.0CTLA4, CD80
39diiodotyrosine4511.0TPO, TG
40cycloheximide4511.0DIO2
41abatacept45 1112.0CTLA4, CD80
42serine4511.0TSHR, IL13, DIO2, CTLA4, CT49
433,3-diiodothyronine4511.0DIO2, LMOD1
44aspartate4510.9TG, TPO
45polysaccharide4510.9TG, TPO, TSHR, IL13
46ctla4-ig4510.9CTLA4, CD80
47carbimazole45 1111.8TSHR, TPO
48perchlorate4510.8TPO, TG
49acetylcholine45 50 29 11 2414.8CTLA4, IL13, TPO, TG
50cholesterol45 29 11 2413.7CTLA4, CD40, CYP27B1, TSHR, TPO

GO Terms for genes affiliated with Graves' Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Graves' Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.9IL13, CD80, CD40, CTLA4

Biological processes related to Graves' Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1T cell costimulationGO:03129510.8CD80, HLA-DQA1, CTLA4
2hormone biosynthetic processGO:04244610.7TG, TPO, DIO2
3thyroid hormone generationGO:00659010.5TG, TPO, DIO2

Products for genes affiliated with Graves' Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Graves' Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet