MCID: GRV001
MIFTS: 63

Graves' Disease malady

Summaries for Graves' Disease

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8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism). it is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. graves disease is the most common cause of hyperthyroidism and occurs most often in women over age 20. however, the disorder may occur at any age and may affect males as well. treatment may include radioiodine therapy, antithyroid drugs, and/or thyroid surgery. last updated: 5/11/2010

MalaCards: Graves' Disease, also known as graves disease, is related to thyroiditis and hyperthyroidism. An important gene associated with Graves' Disease is CTLA4 (cytotoxic T-lymphocyte-associated protein 4), and among its related pathways are Allograft rejection and CD28 co-stimulation. The compounds tyrosine and cysteine have been mentioned in the context of this disorder. Affiliated tissues include thyroid gl, thyroid and eye, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology:8 An autoimmune disease of endocrine system that involves production of excessive amount of thyroid hormones, located in thyroid gland.

Genetics Home Reference:21 Graves disease is a condition that affects the function of the thyroid, which is a butterfly-shaped gland in the lower neck. The thyroid makes hormones that help regulate a wide variety of critical body functions. For example, thyroid hormones influence growth and development, body temperature, heart rate, menstrual cycles, and weight. In people with Graves disease, the thyroid is overactive and makes more hormones than the body needs. The condition usually appears in mid-adulthood, although it may occur at any age.

Wikipedia:63 Graves\' disease (or Basedow-Graves disease) is an autoimmune disease. It most commonly affects the... more...

Description from OMIM:46 275000

Aliases & Classifications for Graves' Disease

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8Disease Ontology, 42NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 10DISEASES, 44Novoseek, 60UMLS, 46OMIM, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

graves' disease 8 42 21
graves disease 8 22 21 10 44 60
exophthalmic goiter 8 42 21
toxic diffuse goiter 21 60
basedow disease 42 21
toxic diffuse goiter with exophthalmos 8
autoimmune hyperthyroidism 21
toxic multinodular goiter 60
graves' hyperthyroidism 42
basedow's disease 21
grave's disease 8
parry disease 42


Related Diseases for Graves' Disease

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17GeneCards, 18GeneDecks
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Diseases in the Graves' Disease family:

Graves Disease 4 Graves Disease 3
Graves Disease 1 Graves Disease 2

Diseases related to Graves' Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 276)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.7TSHR, TPO, TG, PTPN22, CTLA4
2hyperthyroidism31.2CTLA4, DIO2, PTPN22, TPO, TG, CD40
3goiter31.1DIO2, TG, TPO, TSHR, LMOD1
4myxedema30.9TSHR, TG, TPO
5thyrotoxicosis30.9TG, TPO, TSHR
6hypothyroidism30.9TSHR, TG, TPO
7autoimmune thyroiditis30.8TPO, TG
8diabetes mellitus30.8HLA-DQA1, PTPN22, CTLA4, CYP27B1
9subacute thyroiditis30.8TSHR, TG, TPO
10nodular goiter30.7TSHR, CD80, TPO, CTLA4, TG
11multinodular goiter30.7TG, TPO, TSHR
12thyroid cancer30.7TPO, TG, DIO2, TSHR
13adenoma30.6TG, TPO, TSHR, LMOD1, DIO2, CTLA4
14papillary carcinoma30.6TSHR, TPO, TG
15hepatitis30.6CTLA4
16struma ovarii30.6TG, TSHR
17papillary thyroid carcinoma30.5TSHR, TPO, TG
18addison's disease30.5CYP27B1, TG, TPO, PTPN22, CTLA4
19nontoxic goiter30.4TPO, TG, TSHR
20myasthenia gravis30.4CD80, CTLA4
21arthritis30.4CTLA4, IL13, PTPN22, PSMB9, CD80
22hepatitis c30.4TSHR, PSMB9, CTLA4
23endemic goiter30.4TPO, TSHR, TG
24vitiligo30.3CTLA4, TPO, PTPN22
25hypoparathyroidism30.3CTLA4
26rheumatoid arthritis30.2CD40, CD80, IL13, CYP27B1, CTLA4, HTLVR
27vasculitis30.2CD80, CTLA4
28follicular thyroid carcinoma30.2TG, TSHR
29adenocarcinoma30.1CYP27B1, CD80, DIO2, CT49
30multiple sclerosis30.1HLA-DQA1, CD40, CYP27B1, IL13, PTPN22, CTLA4
31systemic lupus erythematosus30.1TSHR, CD40, CD80, CTLA4, PTPN22, HLA-DQA1
32breast cancer30.1CYP27B1, CTLA4, CD40, CD80, LMOD1
33toxic diffuse goiter30.1TPO, TG, TSHR
34connective tissue disease30.1CTLA4, CD40, PTPN22
35congenital hypothyroidism30.1TG, TPO, TSHR
36pernicious anemia30.1TPO, TG
37severe combined immunodeficiency30.1CD40
38melanoma29.8CTLA4, CD40, CD80, CT49, CYP27B1, PSMB9
39celiac disease29.8TG, CTLA4, TPO, PTPN22, HLA-DQA1
40leukemia29.8TSHR, HTLVR, CYP27B1, CD40, CD80
41systemic scleroderma29.8PTPN22, CTLA4, IL13, CD80
42hodgkin's lymphoma29.8IL13, CD40, PSMB9, CD80
43sarcoidosis29.8CD80, IL13, CYP27B1
44wegener's granulomatosis29.8CD80, CTLA4
45uveitis29.8CTLA4
46plummer's disease29.8TPO, TG
47diabetic ketoacidosis29.8CTLA4
48thymoma29.8CTLA4
49allergic rhinitis29.8CTLA4, IL13
50hyperthyroxinemia29.8TSHR, TPO

Graphical network of the top 20 diseases related to Graves' Disease:



Diseases related to graves' disease

Clinical Features for Graves' Disease

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46OMIM
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Clinical features from OMIM:

275000

Drugs & Therapeutics for Graves' Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Graves' Disease

Drug clinical trials:

Search ClinicalTrials for Graves' Disease

Search NIH Clinical Center for Graves' Disease

Search CenterWatch for Graves' Disease

Genetic Tests for Graves' Disease

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22GTR
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Genetic tests related to Graves' Disease:

id Genetic test Affiliating Genes
1 Graves' Disease22

Anatomical Context for Graves' Disease

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Graves' Disease:

32
Thyroid, Eye, Heart, T cells, Skin, Bone, B cells, Testes, Breast, Endothelial, Thymus, Liver, Pituitary, Skeletal muscle, Brain, Ovary, Bone marrow, Lymph node, Monocytes

FMA organs/tissues related to Graves' Disease:

14
Thyroid gl

Animal Models for Graves' Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Graves' Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539711.5TG, PSMB9, CTLA4, HLA-DQA1, CD40, CD80
2MP:000538711.2CD40, HLA-DQA1, CTLA4, PSMB9, CD80, CYP27B1
3MP:000537910.9TG, TSHR, CYP27B1, CD80

Publications for Graves' Disease

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Sources:
50PubMed
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Articles related to Graves' Disease:

(show top 50)    (show all 1323)
idTitleAuthorsYear
1
Ipilimumab-induced orbital inflammation resembling graves disease with subsequent development of systemic hyperthyroidism from ctla-4 receptor suppression. (24398505)
2014
2
Rising serum thyroxine levels and chorea in graves' disease. (23296438)
2013
3
Increased serum interleukin-33 levels in patients with Graves' disease. (23641786)
2013
4
The replication of the association of the rs9355610 within 6p27 with Graves' disease. (24001206)
2013
5
Prediction of late (24-hour) radioactive iodine uptake using early (3-hour) uptake values in Japanese patients with Graves' disease. (22095001)
2012
6
CD40 C/T-1 polymorphism plays different roles in Graves' disease and Hashimoto's thyroiditis: a meta-analysis. (22863718)
2012
7
Polymorphisms of the T-cell immunoglobulin and mucin domain molecule-3 are not associated with autoimmune Graves' disease in a Chinese Han Population. (22968087)
2012
8
Acute recurrent pericarditis accompanied by graves' disease. (22787473)
2012
9
The thyroid function of Graves' disease patients is aggravated by depressive personality during antithyroid drug treatment. (21827669)
2011
10
Graves' disease in a patient with ectopic mediastinal thyroid. (21975399)
2011
11
Concurrent Graves' disease and intracranial arterial stenosis/occlusion: special considerations regarding the state of thyroid function, etiology, and treatment. (21424208)
2011
12
A rare case of resistance to thyroid hormone coexisting with Graves' disease. (21598068)
2011
13
Postoperative hypocalcemia after thyroidectomy for Graves' disease. (20950255)
2010
14
Peripartum cardiomyopathy in a patient with Graves' disease. (19167107)
2010
15
Initial Treatment of Pediatric Graves' Disease with Methimazole: A Retrospective Follow-up Study. (23926385)
2010
16
Hypothyroid Graves' disease complicated with elephantiasis nostras verrucosa (ENV): a case report and review of the literature. (19390996)
2009
17
Association of the -31C/T functional polymorphism in the interleukin-1beta gene with the intractability of Graves' disease and the proportion of T helper type 17 cells. (19793334)
2009
18
Serum concentrations of adiponectin and resistin in hyperthyroid Graves' disease patients. (18997483)
2008
19
Pancytopenia related to Graves' disease. (18299644)
2008
20
Increased serum anti-carbonic anhydrase II antibodies in patients with Graves' disease. (17516290)
2007
21
Contribution of single nucleotide polymorphisms within FCRL3 and MAP3K7IP2 to the pathogenesis of Graves' disease. (16384851)
2006
22
Profound reduction in T-helper (Th) 1 lymphocytes in peripheral blood from patients with concurrent type 1 diabetes and Graves' disease. (16717396)
2006
23
Decreased nerve growth factor levels in hyperthyroid Graves' ophthalmopathy highlighting the role of neuroprotective factor in autoimmune thyroid diseases. (17008110)
2006
24
Graves' disease and coexisting struma ovarii: struma expression of thyrotropin receptors and the presence of thyrotropin receptor stimulating antibodies. (16910883)
2006
25
Graves' disease and bone metabolism]. (17154099)
2006
26
Relationship between CTLA-4 and CD28 molecule expression on T lymphocytes and stimulating and blocking autoantibodies to the TSH-receptor in children with Graves' disease. (16220002)
2005
27
Association of HLA-DR and -DQ genes with Graves disease in Koreans. (15993720)
2005
28
Regression mapping of association between the human leukocyte antigen region and Graves disease. (15558498)
2005
29
CT60 single nucleotide polymorphism of the CTLA-4 gene is associated with susceptibility to Graves' disease in the Taiwanese population. (16081581)
2005
30
Analysis of immune regulatory genes in familial and sporadic Graves' disease. (15356063)
2004
31
Fas ligand gene polymorphisms are not associated with Hashimoto's thyroiditis and Graves' disease. (12559631)
2003
32
Polymorphism in the transmembrane region of the major histocompatibility complex class I chain-related gene A: association of five GCT repetitions with Graves' disease in children. (14588097)
2003
33
Screening for an AIRE-1 mutation in patients with Addison's disease, type 1 diabetes, Graves' disease and Hashimoto's thyroiditis as well as in APECED syndrome. (11298085)
2001
34
Remission and recurrence of hyperthyroid Graves' disease during and after methimazole treatment when assessed by IgE and interleukin 13. (11502776)
2001
35
Thymic hyperplasia in a patient with Graves' disease. (11355328)
2001
36
Malignant hyperthermia in a patient with Graves' disease during subtotal thyroidectomy. (11456272)
2001
37
Vitamin D receptor initiation codon polymorphism in Japanese patients with Graves' disease. (10907990)
2000
38
Production of IL-10 and IL-12 in CD40 and interleukin 4-activated mononuclear cells from patients with Graves' disease. (10843746)
2000
39
The development of Graves' disease and the CTLA-4 gene on chromosome 2q33. (10404810)
1999
40
Provirus load in patients with human T-cell leukemia virus type 1 uveitis correlates with precedent Graves' disease and disease activities. (9703358)
1998
41
Graves' disease after percutaneous ethanol injection for the treatment of autonomous thyroid adenoma. (9648057)
1998
42
Thyrotropin receptor antibodies and Graves' disease, a side-effect of 131I treatment in patients with nontoxic goiter. (9284721)
1997
43
Systemic scleroderma associated with Graves' disease. (9037923)
1996
44
An immunohistochemical study on human leucocyte antigen-DR in Hashimoto thyroiditis and Graves disease]. (9387612)
1996
45
CD31, CD62E, and CD62P identify a specific pattern of endothelial activation in Graves' disease. (7542186)
1995
46
Lack of intrathyroidal tumor necrosis factor alpha in Graves' disease. (8421109)
1993
47
Enhanced suppression of 1,25(OH)2D3 and intact parathyroid hormone in Graves' disease as compared to toxic nodular goiter. (3129167)
1988
48
Ultrastructural and immunological findings in Graves' disease with pretibial myxedema. (6989863)
1980
49
Antithyroid drug therapy for toxic diffuse goiter (Graves disease): thirty years experience in children and adolescents. (69022)
1977
50
The effect of triiodothyronine on cervical lymphoid structures, thyroid activity, IgG and IgM immunoglobulin level and exophthalmos in Graves' disease. (4184992)
1969

Genetic Variations for Graves' Disease

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Expression for genes affiliated with Graves' Disease

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Graves' Disease

Search GEO for disease gene expression data for Graves' Disease.

Pathways for genes affiliated with Graves' Disease

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29KEGG, 51QIAGEN, 53Reactome
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Compounds for genes affiliated with Graves' Disease

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44Novoseek, 24HMDB, 2BitterDB, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience
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Compounds related to Graves' Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1tyrosine4412.0CTLA4, DIO2, CD40, CD80, CYP27B1, IL13
2cysteine4411.9CT49, CTLA4, DIO2, CD40, CYP27B1, IL13
3estrogen4411.7CT49, CTLA4, DIO2, CYP27B1, IL13, LMOD1
4retinoic acid44 2412.7CT49, DIO2, CD40, CYP27B1, IL13, TSHR
5oligonucleotide4411.6HTLVR, CT49, HLA-DQA1, CD40, CYP27B1, TSHR
6iodine44 2412.5TG, TPO, TSHR, LMOD1, DIO2, CTLA4
7thyroxine44 2412.5DIO2, IL13, LMOD1, TSHR, TPO, TG
8paraffin4411.5CT49, HLA-DQA1, CD40, CYP27B1, TSHR, TG
9thymidine44 2412.5CT49, CTLA4, CD40, IL13, TSHR, TG
10125i4411.4TG, TPO, TSHR, LMOD1, DIO2
11iodide44 2412.4DIO2, LMOD1, TSHR, TPO, TG
12methimazole44 2 1113.4DIO2, IL13, TSHR, TPO, TG
13triiodothyronine4411.4DIO2, LMOD1, TSHR, TPO, TG
14steroid4411.4CT49, CTLA4, CD40, CYP27B1, IL13, TPO
15mannose4411.4CD40, CD80, IL13, TSHR, TG
16ionomycin4411.4CTLA4, CD40, CD80, IL13, TSHR
17ribonucleic acid4411.4DIO2, CD40, TSHR, TPO, TG
18arginine4411.3HLA-DQA1, IL13, PTPN22, TSHR, TPO, TG
19alanine4411.3CT49, CTLA4, DIO2, IL13, TSHR, TG
20dexamethasone44 49 28 1114.3CTLA4, DIO2, CD80, IL13, LMOD1
21cyclosporin a44 28 5913.3TG, IL13, CD80, CD40, CTLA4
22rituximab44 49 1113.3IL13, CD80, CD40, CTLA4
23allergens4411.3CTLA4, CD40, CD80, IL13
24dithiothreitol4411.3DIO2, CD40, LMOD1, TPO
25prednisolone44 28 1113.2CD40, IL13, TSHR, TG
26sodium iodide4411.2TSHR, TPO, TG
27amiodarone44 49 28 1114.1TG, TPO, LMOD1
28propylthiouracil44 2 1113.1DIO2, TG
29chloramphenicol44 2 1113.1CD40, CYP27B1, IL13, TSHR
30forskolin44 49 1113.1CT49, TSHR
31glutamate4411.1TPO, PTPN22
32il 104411.1IL13, CD40, CTLA4
33iodotyrosine44 2412.1TG, TPO
34adenylate4411.0CD40, IL13, TSHR, TPO, TG
35n-bromoacetyl-3,3,5-triiodo-l-thyronine4411.0LMOD1, DIO2
36hydrocortisone44 2 59 1114.0TG, TPO
37selenium44 2412.0TG, TPO, DIO2
38belatacept44 1112.0CTLA4, CD80
39diiodotyrosine4411.0TPO, TG
40cycloheximide4411.0DIO2
41abatacept44 1112.0CTLA4, CD80
42serine4411.0TSHR, IL13, DIO2, CTLA4, CT49
433,3-diiodothyronine4411.0DIO2, LMOD1
44aspartate4410.9TG, TPO
45polysaccharide4410.9TG, TPO, TSHR, IL13
46ctla4-ig4410.9CTLA4, CD80
47carbimazole44 1111.8TSHR, TPO
48perchlorate4410.8TPO, TG
49acetylcholine44 49 28 11 2414.8CTLA4, IL13, TPO, TG
50cholesterol44 28 11 2413.7CTLA4, CD40, CYP27B1, TSHR, TPO

GO Terms for genes affiliated with Graves' Disease

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16Gene Ontology
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Cellular components related to Graves' Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00989710.9IL13, CD80, CD40, CTLA4

Biological processes related to Graves' Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1T cell costimulationGO:03129510.8CD80, HLA-DQA1, CTLA4
2hormone biosynthetic processGO:04244610.7TG, TPO, DIO2
3thyroid hormone generationGO:00659010.5TG, TPO, DIO2

Products for genes affiliated with Graves' Disease

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  • Antibodies
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Sources for Graves' Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet