MCID: GRV001
MIFTS: 64

Graves' Disease malady

Rare diseases, Immune diseases, Endocrine diseases categories
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Summaries for Graves' Disease

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8Disease Ontology, 21Genetics Home Reference, 43NIH Rare Diseases, 65Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Graves' disease is an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism). it is caused by an abnormal immune system response that causes the thyroid gland to produce too much thyroid hormones. graves disease is the most common cause of hyperthyroidism and occurs most often in women over age 20. however, the disorder may occur at any age and may affect males as well. treatment may include radioiodine therapy, antithyroid drugs, and/or thyroid surgery. last updated: 5/11/2010

MalaCards: Graves' Disease, also known as graves disease, is related to thyroiditis and goiter. An important gene associated with Graves' Disease is CTLA4 (cytotoxic T-lymphocyte-associated protein 4), and among its related pathways are Metabolism of steroid hormones and vitamin D and Vitamin D synthesis. The compounds iodotyrosine and diiodotyrosine have been mentioned in the context of this disorder. Affiliated tissues include thyroid gl, thyroid and eye, and related mouse phenotypes are skeleton and immune system.

Disease Ontology:8 An autoimmune disease of endocrine system that involves production of excessive amount of thyroid hormones, located in thyroid gland.

Genetics Home Reference:21 Graves disease is a condition that affects the function of the thyroid, which is a butterfly-shaped gland in the lower neck. The thyroid makes hormones that help regulate a wide variety of critical body functions. For example, thyroid hormones influence growth and development, body temperature, heart rate, menstrual cycles, and weight. In people with Graves disease, the thyroid is overactive and makes more hormones than the body needs. The condition usually appears in mid-adulthood, although it may occur at any age.

Wikipedia:65 Graves\' disease (or Basedow-Graves disease) is an autoimmune disease. It most commonly affects the... more...

Description from OMIM:47 275000

Aliases & Classifications for Graves' Disease

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8Disease Ontology, 43NIH Rare Diseases, 22GTR, 21Genetics Home Reference, 10DISEASES, 45Novoseek, 62UMLS, 40NCIt, 58SNOMED-CT, 35MeSH, 47OMIM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Immune diseases, Endocrine diseases


Aliases & Descriptions:

graves' disease 8 43 21
graves disease 8 22 21 10 45 62
exophthalmic goiter 8 43 21
toxic diffuse goiter 21 62
basedow disease 43 21
toxic diffuse goiter with exophthalmos 8
autoimmune hyperthyroidism 21
toxic multinodular goiter 62
graves' hyperthyroidism 43
basedow's disease 21
grave's disease 8
parry disease 43


Related Diseases for Graves' Disease

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17GeneCards, 18GeneDecks
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Diseases in the Graves' Disease family:

Graves Disease 4 Graves Disease 3
Graves Disease 1 Graves Disease 2

Diseases related to Graves' Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 245)
idRelated DiseaseScoreTop Affiliating Genes
1thyroiditis31.7CTLA4, TSHR, TG, TPO, PTPN22
2goiter31.0TG, DIO2, TPO, LMOD1, TSHR
3hyperthyroidism31.0CTLA4, CD40, DIO2, TSHR, LMOD1, TG
4myxedema31.0TG, TSHR, TPO
5thyrotoxicosis30.9TPO, TSHR, TG
6hypothyroidism30.9TG, TPO, TSHR
7subacute thyroiditis30.8TPO, TSHR, TG
8diabetes mellitus30.7CYP27B1, PTPN22, GC, CTLA4
9thyroid cancer30.7TPO, TG, TSHR
10multinodular goiter30.7TSHR, TG, TPO
11struma ovarii30.7TG, TSHR
12autoimmune thyroiditis30.7TG, TPO
13nodular goiter30.6TG, TSHR, CTLA4, TNFRSF4, TPO
14type 1 diabetes mellitus30.6CTLA4, TPO
15adenoma30.6CTLA4, TPO, DIO2, TG, TSHR, LMOD1
16thyroid adenoma30.5TPO, TG, TSHR, DIO2
17papillary thyroid carcinoma30.5TPO, TSHR, TG
18addison's disease30.4CTLA4, TG, TPO, PTPN22, CYP27B1
19vitiligo30.4PTPN22, CTLA4, TPO
20nontoxic goiter30.3TSHR, TG, TPO
21papillary carcinoma30.3TPO, TG, TSHR
22follicular thyroid carcinoma30.2TSHR, TG
23pernicious anemia30.2TPO, TG
24toxic diffuse goiter30.1TSHR, TG, TPO
25congenital hypothyroidism30.1TSHR, TPO, TG
26wegener's granulomatosis30.0CTLA4
27rheumatoid arthritis30.0CD40, HTLVR, CYP27B1, TNFRSF4, CTLA4, PTPN22
28thyroid agenesis30.0TG, TSHR
29multiple sclerosis29.9CD40, CTLA4, GC, HTLVR, PTPN22, CYP27B1
30plummer's disease29.9TPO, TG
31connective tissue disease29.9PTPN22, CTLA4, CD40
32turner syndrome29.9TPO, TG
33hyperthyroxinemia29.9TSHR, TPO
34eye disease29.9TSHR, LMOD1
35systemic lupus erythematosus29.9PTPN22, TSHR, TPO, CD40, CTLA4, TNFRSF4
36celiac disease29.9PTPN22, TPO, CTLA4, TG
37t-cell leukemia29.8TNFRSF4, HTLVR, CD40
38melanoma29.6TNFRSF4, CD40, CTLA4, TSHR, CYP27B1
39leukemia29.6TNFRSF4, HTLVR, CYP27B1, TSHR, CD40
40exophthalmos10.5
41thymic hyperplasia10.5
42hepatitis10.4
43mediastinitis10.4
44myasthenia gravis10.3
45insulin autoimmune syndrome10.3
46hepatitis c10.2
47arthritis10.2
48purpura10.2
49thyrotoxic periodic paralysis10.2
50endotheliitis10.2

Graphical network of the top 20 diseases related to Graves' Disease:



Diseases related to graves' disease

Symptoms for Graves' Disease

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47OMIM
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Clinical features from OMIM:

275000

Drugs & Therapeutics for Graves' Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Graves' Disease

Search NIH Clinical Center for Graves' Disease

Genetic Tests for Graves' Disease

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22GTR
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Genetic tests related to Graves' Disease:

id Genetic test Affiliating Genes
1 Graves' Disease22

Anatomical Context for Graves' Disease

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33MalaCards, 14FMA
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MalaCards organs/tissues related to Graves' Disease:

33
Thyroid, Eye, T cells, Skin, Heart, Bone, B cells, Testes, Endothelial, Breast, Pituitary, Liver, Thymus, Skeletal muscle, Ovary, Brain, Monocytes, Lymph node, Bone marrow

FMA organs/tissues related to Graves' Disease:

14
Thyroid gl

Animal Models for Graves' Disease or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Graves' Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.7CYP27B1, TPO, DIO2, GC, CD40, CTLA4
2MP:00053878.7TNFRSF4, PTPN22, TPO, TSHR, CD40, CTLA4
3MP:00053798.7CTLA4, CYP27B1, PTPN22, TPO, TG, TSHR
4MP:00053978.4CYP27B1, TNFRSF4, PTPN22, TPO, TG, TSHR
5MP:00053767.8CYP27B1, PTPN22, DBP, TPO, TG, TSHR

Publications for Graves' Disease

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Sources:
52PubMed
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Articles related to Graves' Disease:

(show top 50)    (show all 1283)
idTitleAuthorsYear
1
Left-shifted relation between calcium and parathyroid hormone in Graves' Disease. (24248181)
2013
2
Anaplastic thyroid carcinoma following radioactive iodine therapy for graves' disease. (24396653)
2013
3
The negative correlation between thyrotropin receptor-stimulating antibodies and bone mineral density in postmenopausal patients with Graves' disease. (23612147)
2013
4
Unexpected conversion from hypothyroidism to an euthyroid state due to Graves' disease in a patient with an ectopic thyroid. (24282039)
2013
5
Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis. (23612905)
2013
6
Mental health status and factors that influence the course of Graves' disease and antithyroid treatments. (23070829)
2012
7
Graves' disease in two pregnancies complicated by fetal goitrous hypothyroidism: successful in utero treatment with levothyroxine. (21162688)
2011
8
Thymic Hyperplasia Associated with Graves' Disease in a 10-year-old Boy. (23926397)
2011
9
Graves' disease. When thyroid hormones run wild. (21200368)
2011
10
Serum chemokine (C-X-C motif ) ligand 10 levels are elevated in patients with Graves' disease in long-term remission. (20144041)
2010
11
Association analysis of polymorphisms in IL-3, IL-4, IL-5, IL-9, and IL-13 with Graves' disease. (20332709)
2010
12
Cancer risk in patients hospitalised for Graves' disease: a population-based cohort study in Sweden. (20354521)
2010
13
The interleukin-1 family gene polymorphisms and Graves' disease. (20400062)
2010
14
Thyroid stimulating hormone receptor (TSHR) intron 1 variants are major risk factors for Graves' disease in three European Caucasian cohorts. (21124799)
2010
15
Somatostatin receptor 2 expression determined by immunohistochemistry in cold thyroid nodules exceeds that of hot thyroid nodules, papillary thyroid carcinoma, and Graves' disease. (20450431)
2010
16
Resistance to thyroid hormone in a patient with coexisting Graves' disease. (20151830)
2010
17
Clinical features of primary hyperthyroidism caused by Graves' disease admixed with resistance to thyroid hormone (P453T). (20574139)
2010
18
Familial risks for hospitalized Graves' disease and goiter. (19661127)
2009
19
Angiogenic study in Graves' disease treated with thyroid arterial embolization. (19796574)
2009
20
Severe ophthalmopathy developing after treatment of coexisting malignant struma ovarii and Graves' disease. (19772400)
2009
21
The rs1990760 polymorphism within the IFIH1 locus is not associated with Graves' disease, Hashimoto's thyroiditis and Addison's disease. (19961590)
2009
22
High iodine (substrate) turnover Graves' disease: the intriguing 'rapid responder' variant of thyrotoxicosis. (18941129)
2008
23
Analysis of HLA class II genes in Hashimoto's thyroiditis reveals differences compared to Graves' disease. (18449200)
2008
24
Association of tumour necrosis factor alpha (TNF-alpha) polymorphisms with Graves' disease: A meta-analysis. (18472000)
2008
25
B cells from patients with Graves' disease aberrantly express the IGF-1 receptor: implications for disease pathogenesis. (18832736)
2008
26
The common variants of E-selectin gene in Graves' disease. (18094708)
2008
27
The adaptation and relationship of FGF-23 to changes in mineral metabolism in Graves' disease. (17437520)
2007
28
Correlation between serum osteoprotegerin and biomarkers of bone metabolism during anti-thyroid treatment in patients with Graves' disease. (16912510)
2006
29
Elephantiasis Nostras Verrucosa: a rare thyroid dermopathy in Graves' disease. (16121817)
2005
30
A haplotype of the CYP27B1 promoter is associated with autoimmune Addison's disease but not with Graves' disease in a UK population. (15956353)
2005
31
Gray-scale and color Doppler sonographic findings in a case of mesenteric Castleman's disease incidentally detected in a patient with Graves' disease. (16196012)
2005
32
Pretibial myxedema, ophthalmopathy and acropachy in a male patient with Graves' disease. (17642674)
2004
33
Reversible mitral valve prolapse and mitral regurgitation in children with Graves' disease. (15506680)
2004
34
Dermopathy of Graves' disease (pretibial myxedema): long-term outcome. (11836263)
2002
35
Frequency of appearance of myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) in Graves' disease patients treated with propylthiouracil and the relationship between MPO-ANCA and clinical manifestations. (11380496)
2001
36
Elephantiasic pretibial myxedema: insight into and a hypothesis regarding the pathogenesis of the extrathyroidal manifestations of Graves' disease. (11014313)
2000
37
An elevation of serum immunoglobulin E provides a new aspect of hyperthyroid Graves' disease. (10946880)
2000
38
Thyroid-associated ophthalmopathy in black South African patients with Graves' disease: relationship to antiflavoprotein antibodies. (9848717)
1998
39
CTLA4 gene polymorphism confers susceptibility to Graves' disease in Japanese. (9459626)
1997
40
CTLA4 alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus. (8989248)
1997
41
Expression of membrane and soluble intercellular adhesion molecule-1 in Graves' disease. (9343311)
1997
42
Binding of antithyrotropin receptor autoantibodies in Graves' disease serum to nascent, in vitro translated thyrotropin receptor: ability to map epitopes recognized by antibodies. (8636291)
1996
43
Systemic scleroderma associated with Graves' disease. (9037923)
1996
44
CD31, CD62E, and CD62P identify a specific pattern of endothelial activation in Graves' disease. (7542186)
1995
45
Identification of thyroid stimulating hormone receptor-specific T cells in Graves' disease thyroid using autoantigen-transfected Epstein-Barr virus-transformed B cell lines. (7615799)
1995
46
A case of pretibial myxedema associated with Graves' disease: an immunohistochemical study of serum-derived hyaluronan-associated protein. (8648004)
1995
47
Soluble intercellular adhesion molecule-1 (sICAM-1) in Graves' disease. (7866729)
1994
48
Dynamic changes in soluble interleukin-2 receptor levels during treatment of Graves' disease. Correlation with disease activity. (1916654)
1991
49
Association of HLA antigen and restriction fragment length polymorphism of T cell receptor beta-chain gene with Graves' disease and Hashimoto's thyroiditis. (2567295)
1989
50
Ultrastructural and immunological findings in Graves' disease with pretibial myxedema. (6989863)
1980

Variations for Graves' Disease

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Expression for genes affiliated with Graves' Disease

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Graves' Disease

Search GEO for disease gene expression data for Graves' Disease.

Pathways for genes affiliated with Graves' Disease

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Sources:
50PathCards, 55Reactome, 38NCBI BioSystems Database, 30KEGG, 53QIAGEN
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Compounds for genes affiliated with Graves' Disease

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Sources:
45Novoseek, 24HMDB, 61Tocris Bioscience, 11DrugBank, 51PharmGKB, 29IUPHAR, 3BitterDB
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Compounds related to Graves' Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 60)
idCompoundScoreTop Affiliating Genes
1iodotyrosine45 2411.4TPO, TG
2diiodotyrosine4510.4TG, TPO
3perchlorate4510.3TG, TPO
4n-bromoacetyl-3,3,5-triiodo-l-thyronine4510.3LMOD1, DIO2
53,3-diiodothyronine4510.3LMOD1, DIO2
6alfacalcidol45 61 1112.3GC, CYP27B1
7carbimazole45 1111.3TSHR, TPO
8sodium iodide4510.2TPO, TG, TSHR
9selenium45 2411.1DIO2, TG, TPO
10amiodarone45 51 29 1113.1LMOD1, TG, TPO
11amino acid4510.0TSHR, TPO
12prednisolone45 29 1112.0CD40, TSHR, TG
13liothyronine51 24 1112.0DIO2, TPO
14methimazole45 3 1112.0TPO, TG, TSHR, DIO2
15sialic acid4510.0TG, TSHR, GC
16hydrocortisone45 3 61 1112.9CD40, TG, TPO
17ionomycin459.9TNFRSF4, TSHR, CD40, CTLA4
18chloramphenicol45 3 51 1112.8CD40, GC, TSHR, CYP27B1
19dithiothreitol459.8TPO, LMOD1, DIO2, CD40
20paraffin459.8CD40, TSHR, TG, CYP27B1
21ribonucleic acid459.7TPO, TG, TSHR, DIO2, CD40
22gliadin459.7TG, TPO
23genistein45 29 61 3 24 1114.7CYP27B1, TPO, TG, CD40
24propylthiouracil45 3 1111.7TPO, TG, LMOD1, TSHR, DIO2
25125i459.7TPO, TG, LMOD1, TSHR, DIO2
26iodide45 2410.7TPO, TG, LMOD1, TSHR, DIO2
27triiodothyronine459.6TPO, TG, LMOD1, TSHR, DIO2
28adenylate459.6TPO, TG, TSHR, GC, CD40
29forskolin45 51 1111.6CYP27B1, TPO, TSHR, DIO2, CD40
30cycloheximide459.6CYP27B1, TPO, TG, DIO2, CD40
31threonine459.6TSHR, DIO2, GC, CD40, CTLA4
32lysine459.6CYP27B1, TPO, TSHR, CTLA4
33hydrogen45 2410.6CD40, TSHR, TPO, CYP27B1
34thymidine45 2410.6CTLA4, CD40, TSHR, TG
35allergens459.5IGES, CD40, CTLA4
36iodine45 2410.5CTLA4, DIO2, TSHR, LMOD1, TG, TPO
37thyroxine45 2410.4TPO, TG, LMOD1, TSHR, DIO2, GC
38glucose459.4CYP27B1, TSHR, DIO2, GC, CD40, CTLA4
39cholesterol45 29 24 1112.4CYP27B1, TPO, TSHR, GC, CD40, CTLA4
40lipid459.3CYP27B1, TPO, TSHR, GC, CD40, CTLA4
41glutamate459.3PTPN22, TPO, TG, TSHR, GC, CD40
42acetylcholine45 51 29 24 1113.3IGES, TPO, TG, CTLA4
43retinoic acid45 2410.2CYP27B1, TPO, TG, TSHR, DIO2, GC
44estrogen459.2CYP27B1, TG, LMOD1, TSHR, DIO2, GC
45oligonucleotide459.1CYP27B1, TPO, TSHR, HTLVR, CD40
46cyclosporin a45 29 6111.1CTLA4, CD40, TG, TNFRSF4, IGES
47cysteine458.9CYP27B1, TPO, TG, LMOD1, TSHR, DIO2
48steroid458.8IGES, CYP27B1, TPO, GC, CD40, CTLA4
49calcium45 51 24 1111.7CYP27B1, TPO, TSHR, DIO2, GC, CD40
50tyrosine458.7CYP27B1, PTPN22, TPO, TG, LMOD1, TSHR

GO Terms for genes affiliated with Graves' Disease

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16Gene Ontology
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Cellular components related to Graves' Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.4CTLA4, CD40, TNFRSF4
2integral component of plasma membraneGO:0058879.2CTLA4, CD40, TSHR, TPO, TNFRSF4

Biological processes related to Graves' Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of B cell proliferationGO:0308909.9CD40, TNFRSF4
2hormone biosynthetic processGO:0424469.8DIO2, TG, TPO
3thyroid hormone generationGO:0065909.7TPO, TG, DIO2
4vitamin D metabolic processGO:0423599.7GC, CYP27B1

Products for genes affiliated with Graves' Disease

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Graves' Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet