MCID: GRW007
MIFTS: 52

Growth Hormone Deficiency malady

Endocrine category

Summaries for Growth Hormone Deficiency

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Growth hormone deficiency is characterized by abnormally short height due to lack (or shortage) of growth hormone. it can be congenital (present at birth) or acquired. most of the time, no single clear cause can be identified. most cases are identified in children. although it is uncommon, growth hormone deficiency may also be diagnosed in adults. too little growth hormone can cause short stature in children, and changes in muscle mass, cholesterol levels, and bone strength in adults. in adolescents, puberty may be delayed or absent. treatment involves growth hormone injections. last updated: 9/28/2011

MalaCards: Growth Hormone Deficiency is related to isolated growth hormone deficiency and short stature. An important gene associated with Growth Hormone Deficiency is GH1 (growth hormone 1), and among its related pathways are Rho Family GTPases and G-Beta Gamma Signaling. The compounds hexarelin and ghrp have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Wikipedia:64 Growth hormone deficiency (GHD) is a medical condition, caused by problems arising in the pituitary... more...

Aliases & Classifications for Growth Hormone Deficiency

Sources:
43NIH Rare Diseases, 45Novoseek
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine


Aliases & Descriptions:

growth hormone deficiency 43 45


Related Diseases for Growth Hormone Deficiency

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Growth Hormone Deficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 250)
idRelated DiseaseScoreTop Affiliating Genes
1isolated growth hormone deficiency31.7GH1, POU1F1
2short stature31.3IGF1, IGFBP3, PROP1, GH1, GHRH, GHRL
3acromegaly30.9GHRH, GHRL, GHSR, GHRHR, LSL, GH1
4hypoglycemia30.8LSL, GHRL, GHRH, GH1, IGFBP3, IGF1
5turner syndrome30.8IGF1, IGFBP3, GH1
6isolated growth hormone deficiency type 1b30.8GHRHR, GH1
7septo-optic dysplasia30.6POU1F1, PROP1, GH1, HESX1
8dwarfism30.6GHRHR, GHRH, GH1, PROP1, IGFBP3, IGF1
9precocious puberty30.6LSL, GH1, IGFBP3, IGF1, POMC
10deficiency anemia30.6LSL, GHRL, GHRH
11prader-willi syndrome30.6LSL, GHSR, GHRL, GH1, IGF1
12mental retardation30.5SOX3
13atherosclerosis30.5LSL, GHSR, GHRL, IGF1
14pituitary hypoplasia30.4OTX2, POU1F1, PROP1, GHRH, GHRHR, SOX3
15laron syndrome30.4IGF1, IGFBP3, GH1
16adenoma30.4GHRHR, GHSR, GHRL, GHRH, GH1, PROP1
17empty sella syndrome30.4POMC
18prolactinoma30.3GHRHR, GHSR, GH1, IGF1, POU1F1, POMC
19panhypopituitarism30.3PROP1, GH1, HESX1, LHX4, IGF1, POU1F1
20hyperprolactinemia30.3GHRH, GH1, IGF1, POMC
21acth deficiency30.3HESX1, GH1, PROP1, POU1F1, POMC
22insulin resistance30.3LSL, GHRL, GH1, IGFBP3, IGF1
23thyroiditis30.3POMC
24diabetes insipidus30.2POMC, GHRH
25pituitary tumors30.0POU1F1, IGF1, PROP1, GH1, GH2, GHRH
26amenorrhea30.0IGF1, POMC
27anorexia nervosa30.0LSL, GHRL, GHRH, GH1, IGFBP3, IGF1
28osteoporosis30.0IGF1, IGFBP3, GH1, LSL
29cushing's syndrome30.0GH1, POMC
30pituitary apoplexy30.0POMC
31sheehan syndrome30.0IGF1, POMC
32sinusitis30.0BTK
33arthritis30.0POMC, GHRL
34protein s deficiency10.7
35protein c deficiency10.6
36isolated growth hormone deficiency type 210.6
37isolated growth hormone deficiency type 1a10.6
38isolated growth hormone deficiency type 310.6
39protein r deficiency10.6
40mental retardation, x-linked, with isolated growth hormone deficiency10.5
41leptin deficiency10.5
42brain injury10.5
43traumatic brain injury10.5
44agammaglobulinemia10.5
45adult syndrome10.4
46short syndrome10.4
47decr deficiency10.4
48lymphocytic choriomeningitis10.4
49isolated gonadotropin-releasing hormone deficiency10.4
50n syndrome10.3

Graphical network of the top 20 diseases related to Growth Hormone Deficiency:



Diseases related to growth hormone deficiency

Clinical Features for Growth Hormone Deficiency

Drugs & Therapeutics for Growth Hormone Deficiency

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Growth Hormone Deficiency

Drug clinical trials:

Search ClinicalTrials for Growth Hormone Deficiency

Search NIH Clinical Center for Growth Hormone Deficiency

Search CenterWatch for Growth Hormone Deficiency

Genetic Tests for Growth Hormone Deficiency

Anatomical Context for Growth Hormone Deficiency

Sources:
33MalaCards
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MalaCards organs/tissues related to Growth Hormone Deficiency:

33
Bone marrow, Whole blood, Brain, Spinal cord, Heart, Skeletal muscle, Small intestine, Kidney, Liver, Thyroid, Salivary gland, Adrenal gland, Breast, Skin, Uterus, Prostate, T cells, B lymphoblasts, B cells, Endothelial, Hypothalamus, Pituitary

Animal Models for Growth Hormone Deficiency or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for Growth Hormone Deficiency

Sources:
51PubMed
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Articles related to Growth Hormone Deficiency:

(show top 50)    (show all 1031)
idTitleAuthorsYear
1
Submicroscopic deletion involving the fibroblast growth factor receptor 1 gene in a patient with combined pituitary hormone deficiency. (23657145)
2013
2
Adult growth hormone deficiency - benefits, side effects, and risks of growth hormone replacement. (23761782)
2013
3
GH replacement improves quality of life and metabolic parameters in cured acromegalic patients with growth hormone deficiency. (22904173)
2012
4
Growth hormone (GH-1) gene deletions in children with isolated growth hormone deficiency (IGHD). (22016154)
2012
5
Growth hormone deficiency and diabetes insipidus as a complication of endoscopic third ventriculostomy. (23032148)
2012
6
The exon 3-deleted/full-length growth hormone receptor polymorphism and response to growth hormone therapy in growth hormone deficiency and Turner syndrome: a multicenter study. (22456308)
2012
7
Does interferon and ribavirin combination therapy ameliorate growth hormone deficiency in HCV genotype-4 infected patients? (21933670)
2012
8
Analysis of the GH content within archived dried blood spots of newborn screening cards from children diagnosed with growth hormone deficiency after the neonatal period. (21903439)
2011
9
Favorable long-term effects of growth hormone replacement therapy on quality of life, bone metabolism, body composition and lipid levels in patients with adult-onset growth hormone deficiency. (21295507)
2011
10
Cephalometric features in isolated growth hormone deficiency. (21341997)
2011
11
Central corneal thickness in children with growth hormone deficiency. (19508460)
2010
12
Growth hormone deficiency: transition from adolescence to adulthood. Highlights from a Latin-American Serono Symposia International Foundation Conference. (20480720)
2010
13
Changing patterns of the adult growth hormone deficiency diagnosis documented in a decade-long global surveillance database. (19001512)
2009
14
Developmental syndromes: growth hormone deficiency and treatment. (19293579)
2009
15
Unreliability of classic provocative tests for the diagnosis of growth hormone deficiency. (18362508)
2008
16
Effect of growth hormone on cardiac contractility in patients with adult onset growth hormone deficiency. (17826393)
2007
17
Adiposity profile in the dwarf rat: an unusually lean model of profound growth hormone deficiency. (17264226)
2007
18
Management of adult growth hormone deficiency. (17336741)
2007
19
Foot length before and during insulin-like growth factor-I treatment of children with laron syndrome compared to human growth hormone treatment of children with isolated growth hormone deficiency. (18341092)
2007
20
Thyroid morphology and function in adults with untreated isolated growth hormone deficiency. (16394080)
2006
21
Growth hormone deficiency after chemotherapy for acute lymphoblastic leukemia in children who have not received cranial radiation. (16369923)
2006
22
Response to growth hormone with respect to pubertal status on increased dose in idiopathic growth hormone deficiency: an analysis of Turkish children in the KIGS database (Pfizer International Growth Study). (16355808)
2005
23
Gonadotropin releasing hormone analogue therapy in children with isolated growth hormone deficiency: final height benefit from postponing puberty? (16042319)
2005
24
Growth hormone deficiency and HIV infection. (16227051)
2005
25
Improvement in insulin sensitivity without concomitant changes in body composition and cardiovascular risk markers following fixed administration of a very low growth hormone (GH) dose in adults with severe GH deficiency. (16181235)
2005
26
Growth hormone deficiency in pseudohypoparathyroidism type 1a: another manifestation of multihormone resistance. (12970262)
2003
27
A practical approach to the diagnosis of growth hormone (GH) deficiency in patients transitioning to adulthood using GH stimulation testing. (12795366)
2003
28
Responses of bone turnover markers and bone mineral density to growth hormone therapy in children with isolated growth hormone deficiency and multiple pituitary hormone deficiencies. (12099391)
2002
29
Diagnostic value of serum insulin-like growth factor binding protein-3 in children with or without growth hormone deficiency. (12901539)
2002
30
Improved cardiovascular risk factors and cardiac performance after 12 months of growth hormone (GH) replacement in young adult patients with GH deficiency. (11344175)
2001
31
Prevalence of GH-1 gene deletion in patients with isolated growth hormone deficiency in Japan. GH Gene Study Group. (10943739)
2000
32
Long-term hormone replacement therapy in two patients with Kabuki syndrome and growth hormone deficiency. (10829592)
2000
33
Serum IGF-I and IGFBP-3 concentrations do not accurately predict growth hormone deficiency in children with brain tumours. (10469014)
1999
34
Hyperleptinaemia in young adults following cranial irradiation in childhood: growth hormone deficiency or leptin insensitivity? (10396357)
1999
35
High-affinity growth hormone (GH)-binding protein (GHBP), body fat mass, and insulin-like growth factor-binding protein-3 predict the GHBP response to GH therapy in adult GH deficiency syndrome. (10094106)
1999
36
Effect of severe growth hormone (GH) deficiency due to a mutation in the GH-releasing hormone receptor on insulin-like growth factors (IGFs), IGF-binding proteins, and ternary complex formation throughout life. (10566659)
1999
37
Serum levels of insulin-like growth factor I in 152 patients with growth hormone deficiency, aged 19-82 years, in relation to those in healthy subjects. (10372703)
1999
38
Plasma IGF-I is a useful marker of growth hormone deficiency in adults. (10435854)
1999
39
Normal intelligence with severe insulin-like growth factor I deficiency due to growth hormone receptor deficiency: a controlled study in a genetically homogeneous population. (9626125)
1998
40
Observations on the stimulation of growth hormone secretion in patients with growth hormone deficiency. (8769406)
1996
41
Suppression of lymphocytic choriomeningitis virus--induced growth hormone deficiency syndrome by disease-negative virus variants. (8806545)
1996
42
Carbohydrate metabolism in children receiving growth hormone for 5 years. Chronic renal insufficiency compared with growth hormone deficiency, Turner syndrome, and idiopathic short stature. Genentech Collaborative Group. (8792386)
1996
43
A randomized, double blind, placebo-controlled trial on safety and efficacy of recombinant human insulin-like growth factor-I in children with growth hormone receptor deficiency. (7536209)
1995
44
Screening for growth hormone (GH) gene splice-site mutations in sporadic cases with severe isolated GH deficiency using ectopic transcript analysis. (7714096)
1995
45
Familial growth hormone deficiency: a model of dominant and recessive mutations affecting a monomeric protein. (7962317)
1994
46
Isolated growth hormone deficiency type IA associated with a 45-kilobase gene deletion within the human growth hormone gene cluster in an Italian family. (7877887)
1994
47
Insulin-like growth factor I and altered renal hemodynamics in growth hormone deficiency, acromegaly, and type I diabetes mellitus. (8171527)
1994
48
Treatment of isolated growth hormone deficiency type IA due to GH-I gene deletion with recombinant human insulin-like growth factor I. (7509217)
1993
49
Increased body fat mass and decreased extracellular fluid volume in adults with growth hormone deficiency. (8435887)
1993
50
Isolated growth hormone deficiency, type II (sexual ateleiosis, type II). (5173170)
1971

Genetic Variations for Growth Hormone Deficiency

Expression for genes affiliated with Growth Hormone Deficiency

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Growth Hormone Deficiency

Search GEO for disease gene expression data for Growth Hormone Deficiency.

Pathways for genes affiliated with Growth Hormone Deficiency

Sources:
52QIAGEN, 54Reactome, 30KEGG, 38NCBI BioSystems Database
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Pathways related to Growth Hormone Deficiency according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5SOX3, GHRH, GH2, GH1, IGF1, BTK
2
Hide members
10.5BTK, POMC, GH1, GH2, GHRH, GHRHR
3
Hide members
10.5GHRH, GH2, GH1, IGF1, BTK
4
Hide members
10.5GHRH, GH2, GH1, IGF1, BTK
5
Hide members
10.5BTK, IGF1, GH1, GH2, GHRH
6
Hide members
10.5BTK, IGF1, GH1, GH2, GHRH
7
Hide members
10.5GHRH, GH2, GH1, IGF1, BTK
8
Hide members
10.5GHRH, GH2, GH1, IGF1, BTK
9
Hide members
10.5GH2, GH1, IGF1, BTK
10
Hide members
10.5GHRHR, GHSR, GHRL, GHRH, GH2, GH1
11
Hide members
10.5GHRHR, GHSR, GHRL, GHRH, GH2, GH1
12
Hide members
10.5GHRH, GH2, GH1, IGF1

Compounds for genes affiliated with Growth Hormone Deficiency

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 11DrugBank, 50PharmGKB, 24HMDB, 2BitterDB
See all sources

Compounds related to Growth Hormone Deficiency according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1hexarelin45 2911.9POMC, GHRH, GHRL, GHSR, IGF1, GH1
2ghrp4510.9GHSR, GHRHR, GHRL, GHRH, GH1, IGF1
3ribonucleic acid4510.9GHSR, IGFBP3, POMC, POU1F1, IGF1, GH1
4acth4510.9GHRL, IGFBP3, GHRH, GH1, PROP1, IGF1
5octreotide45 60 29 1113.9LSL, GHSR, GHRL, GHRH, GH1, IGFBP3
6pyridostigmine45 1111.9IGF1, GHRL, IGFBP3, GHRH, GH1
7lanreotide45 2911.9GHSR, GHRH, GH1, IGFBP3, IGF1
8gnrh4510.9IGFBP3, PROP1, GH1, GHRL, HESX1, LSL
9pegvisomant45 1111.9GHRH, GH1, IGFBP3, IGF1, GHRL
10bromocriptine29 45 1112.9POMC, IGFBP3, POU1F1, GHRH
11triiodothyronine4510.9LSL, GHRL, IGFBP3, GH1, GHRH, POMC
12arginine4510.9GHRH, GHRL, IGFBP3, GH1, BTK, LSL
13naltrexone45 50 29 1113.9POMC, IGF1, IGFBP3, GH1, GHRH
14acipimox45 2911.9GHRH, GHRL, LSL, IGF1, GH1
15dehydroepiandrosterone sulfate4510.9POMC, IGF1, IGFBP3, GH1, GHRL, LSL
16dexamethasone45 50 29 1113.9GHRHR, POMC, POU1F1, GHRL, GHSR, LSL
17testosterone45 60 11 2413.9PROP1, GH1, GH2, GHRH, GHRL, GHSR
18oxandrolone45 1111.9GHRL, GH1, IGFBP3, IGF1
19thyroxine45 2411.9LSL, GHRL, GHRH, GH1, IGFBP3, IGF1
20dhea4510.9IGF1, POMC, IGFBP3, GH1, GHRL, LSL
21estradiol45 11 2412.9GHSR, LSL, POMC, IGF1, IGFBP3, GH1
22steroid4510.9POMC, POU1F1, IGF1, IGFBP3, PROP1, GH1
23clonidine45 29 1112.9GH1, IGFBP3, GHRH, POMC, IGF1
24hydrocortisone45 2 60 1113.9GHSR, IGF1, GH1, GHRL, LSL, POMC
25glucose4510.8POMC, IGF1, IGFBP3, GH1, GH2, GHRL
26pirenzepine45 29 1112.8GHRL, GHRH, GH1, IGF1
27metformin45 50 1112.8POMC, IGF1, GH1, GHRL, LSL
28forskolin45 50 1112.8POMC, GHRH, POU1F1, GHSR, GHRHR
29c-peptide4510.8IGFBP3, LSL, GHRL, GH1, IGF1
30androstenedione45 2411.8IGFBP3, POMC, IGF1, GH1, LSL
31dopamine45 29 11 2413.8IGF1, GHRL, GHSR, GHRH
32deoxypyridinoline4510.8IGF1, IGFBP3, LSL, GH1
33vitamin d4510.8GHRH, GHRL, GH1, IGFBP3, IGF1, POU1F1
34adenylate4510.8GHRL, POMC, GHSR, IGFBP3, GH1, GHRH
35methimazole45 2 1112.8POMC, LSL, IGFBP3, IGF1
36norepinephrine45 11 2412.8POMC, GHRH
37naloxone45 50 29 1113.8GHRH, GHRL, POMC, GH1
38progesterone45 60 29 11 2414.7POU1F1, POMC, IGF1, IGFBP3, GH1, GHRH
39raloxifene45 29 50 1113.7LSL, GH1, IGF1, IGFBP3
40opiate4510.7GH1, GHRH, GHRL, POMC
41megestrol acetate4510.7IGFBP3, IGF1, POMC
42serine4510.7GHRH, GH1, POMC, PROP1, GHRL
43fenfluramine29 45 1112.6GHRH, IGFBP3, POMC
44intralipid4510.6GH1, GHRL, LSL
45epinephrine45 11 2412.6LSL, GHRL, GH1, IGFBP3, POMC
46creatinine4510.5POMC, IGF1, GHRL, LSL, GH1, IGFBP3
47cortisone45 2411.5POMC, IGF1, GH1
48clomiphene citrate4510.5GH1, IGFBP3, IGF1
49corticosterone45 60 2412.4GH1, LSL, GHRL, POMC
50alanine4510.2SOX3, GH1, POMC, LSL, POU1F1, GHRL

GO Terms for genes affiliated with Growth Hormone Deficiency

Sources:
16Gene Ontology
See all sources

Cellular components related to Growth Hormone Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor binding protein complexGO:01694210.5IGF1, IGFBP3
2secretory granule lumenGO:03477410.5POMC, GHRL
3extracellular regionGO:00557610.4CSHL1, GHRL, GHRH, GH2, GH1, IGFBP3
4extracellular spaceGO:00561510.2GHRL, GHRH, GH1, IGFBP3, IGF1, POMC

Biological processes related to Growth Hormone Deficiency according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.8IGF1, IGFBP3, GH1, GHRH, GHSR, GHRHR
2positive regulation of multicellular organism growthGO:04001810.8GHRHR, GHSR, GHRL, GHRH, GH1, POU1F1
3growth hormone secretionGO:03025210.8GHRHR, GHSR, GHRL, GHRH
4positive regulation of growth hormone secretionGO:06012410.8GHRH, GHRL, GHRHR
5somatotropin secreting cell developmentGO:06013310.7POU1F1, GHRHR
6positive regulation of appetiteGO:03210010.7GHSR, GHRL
7water homeostasisGO:03010410.7IGF1, GHRHR
8negative regulation of tumor necrosis factor biosynthetic processGO:04253610.7GHRL, GHSR
9negative regulation of interleukin-6 biosynthetic processGO:04540910.7GHSR, GHRL
10negative regulation of interleukin-1 beta productionGO:03269110.7GHRL, GHSR
11response to foodGO:03209410.6GHRH, GHSR
12adult feeding behaviorGO:00834310.6GHSR, GHRL
13actin polymerization or depolymerizationGO:00815410.5GHRL, GHSR
14determination of adult lifespanGO:00834010.5POU1F1, GHRHR
15decidualizationGO:04669710.5GHRL, GHSR
16positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.4GH1, IGF1
17cell fate specificationGO:00170810.2POU1F1, OTX2

Molecular functions related to Growth Hormone Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth hormone-releasing hormone receptor activityGO:01652010.5GHSR, GHRHR
2hormone activityGO:00517910.4POMC, IGF1, GH1, GH2, CSHL1
3growth hormone-releasing hormone activityGO:01660810.2GHRH, GHRL

Products for genes affiliated with Growth Hormone Deficiency

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  • Proteins
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  • Antibodies

Sources for Growth Hormone Deficiency

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet