MCID: GRW007
MIFTS: 39

Growth Hormone Deficiency malady

Endocrine diseases category

Summaries for Growth Hormone Deficiency

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Growth hormone deficiency is characterized by abnormally short height due to lack (or shortage) of growth hormone. it can be congenital (present at birth) or acquired. most of the time, no single clear cause can be identified. most cases are identified in children. although it is uncommon, growth hormone deficiency may also be diagnosed in adults. too little growth hormone can cause short stature in children, and changes in muscle mass, cholesterol levels, and bone strength in adults. in adolescents, puberty may be delayed or absent. treatment involves growth hormone injections. last updated: 9/28/2011

MalaCards: Growth Hormone Deficiency is related to hypopituitarism and acromegaly. An important gene associated with Growth Hormone Deficiency is GH1 (growth hormone 1), and among its related pathways are Rho Family GTPases and G-Beta Gamma Signaling. The compounds hexarelin and ghrp have been mentioned in the context of this disorder. Affiliated tissues include bone and pituitary, and related mouse phenotypes are endocrine/exocrine gland and homeostasis/metabolism.

Wikipedia:63 Growth hormone deficiency (GHD) is a medical condition, caused by problems arising in the pituitary... more...

Aliases & Classifications for Growth Hormone Deficiency

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42NIH Rare Diseases, 44Novoseek
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

growth hormone deficiency 42 44


Related Diseases for Growth Hormone Deficiency

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17GeneCards, 18GeneDecks
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Diseases related to Growth Hormone Deficiency via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 227)
idRelated DiseaseScoreTop Affiliating Genes
1hypopituitarism30.9LHX4, HESX1, POMC, POU1F1, IGF1, IGFBP3
2acromegaly30.9IGF1, IGFBP3, GH1
3isolated growth hormone deficiency30.9GH1, POU1F1
4hypoglycemia30.8LSL, GHRL, GHRH, GH1, IGFBP3, IGF1
5isolated growth hormone deficiency type 1b30.8GHRHR, GH1
6turner syndrome30.8IGF1, IGFBP3, GH1
7thyroiditis30.7POMC
8obesity30.6LSL, HESX1, GHSR, GHRL, GHRH, GH1
9dwarfism30.6GHRHR, GHRH, GH1, PROP1, IGFBP3, IGF1
10hypothyroidism30.6IGFBP3, GHRL, LSL
11deficiency anemia30.6LSL, GHRL, GHRH
12prader-willi syndrome30.5LSL, GHSR, GHRL, GH1, IGF1
13diabetes mellitus30.5LSL, GHRL, GH1, IGFBP3, IGF1, POMC
14atherosclerosis30.4LSL, GHSR, GHRL, IGF1
15pituitary adenoma30.4GHRHR, GHSR, GHRL, GHRH, GH1, PROP1
16pituitary hypoplasia30.4OTX2, POU1F1, PROP1, GHRH, GHRHR, SOX3
17hypogonadism30.4POMC, POU1F1, IGF1, IGFBP3, PROP1, GH1
18laron syndrome30.4IGF1, IGFBP3, GH1
19adenoma30.4GHRHR, GHSR, GHRL, GHRH, GH1, PROP1
20empty sella syndrome30.4POMC
21prolactinoma30.2GHRHR, GHSR, GH1, IGF1, POU1F1, POMC
22panhypopituitarism30.2PROP1, GH1, HESX1, LHX4, IGF1, POU1F1
23craniopharyngioma30.2POMC, IGF1, PROP1, GH1
24hyperprolactinemia30.2GHRH, GH1, IGF1, POMC
25diabetes insipidus30.2POMC, GHRH
26septo-optic dysplasia30.0POU1F1, PROP1, GH1, HESX1
27amenorrhea30.0IGF1, POMC
28anorexia nervosa30.0LSL, GHRL, GHRH, GH1, IGFBP3, IGF1
29lipodystrophy30.0LSL
30eating disorder30.0GHRL
31osteoporosis30.0IGF1, IGFBP3, GH1, LSL
32cushing's syndrome30.0GH1, POMC
33hypertension30.0POMC, IGF1
34pituitary apoplexy30.0POMC
35rheumatoid arthritis30.0BTK, GHRL
36myopathy30.0POMC, IGF1
37arthritis30.0POMC, GHRL
38isolated growth hormone deficiency type 210.6
39isolated growth hormone deficiency type 1a10.6
40isolated growth hormone deficiency type 310.6
41mental retardation, x-linked, with isolated growth hormone deficiency10.5
42agammaglobulinemia10.4
43adult syndrome10.4
44leukemia10.4
45lymphocytic choriomeningitis10.4
46pseudohypoparathyroidism10.4
47isolated gonadotropin-releasing hormone deficiency10.4
48fanconi's anemia10.3
49cerebritis10.3
50acute leukemia10.3

Graphical network of the top 20 diseases related to Growth Hormone Deficiency:



Diseases related to growth hormone deficiency

Clinical Features for Growth Hormone Deficiency

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Drugs & Therapeutics for Growth Hormone Deficiency

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Growth Hormone Deficiency

Drug clinical trials:

Search ClinicalTrials for Growth Hormone Deficiency

Search NIH Clinical Center for Growth Hormone Deficiency

Search CenterWatch for Growth Hormone Deficiency

Genetic Tests for Growth Hormone Deficiency

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Anatomical Context for Growth Hormone Deficiency

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32MalaCards
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MalaCards organs/tissues related to Growth Hormone Deficiency:

32
Bone, Pituitary

Animal Models for Growth Hormone Deficiency or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Growth Hormone Deficiency:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537910.6OTX2, LHX4, HESX1, SOX3, GHRHR, GHRL
2MP:000537610.5GHRH, GHRL, GHSR, GHRHR, SOX3, LHX4
3MP:000538910.5GHRHR, GHRH, GH1, PROP1, IGF1, POU1F1
4MP:000537810.5SOX3, GHRHR, GHSR, GHRH, GH1, PROP1
5MP:000537510.4GHRHR, GHSR, GHRL, GH1, IGFBP3, IGF1
6MP:000363110.2LHX4, HESX1, SOX3, GHRHR, GHRH, GH1

Publications for Growth Hormone Deficiency

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Genetic Variations for Growth Hormone Deficiency

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Expression for genes affiliated with Growth Hormone Deficiency

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Growth Hormone Deficiency

Search GEO for disease gene expression data for Growth Hormone Deficiency.

Pathways for genes affiliated with Growth Hormone Deficiency

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51QIAGEN, 53Reactome, 29KEGG, 37NCBI BioSystems Database
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Pathways related to Growth Hormone Deficiency according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.5SOX3, GHRH, GH2, GH1, IGF1, BTK
2
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10.5BTK, POMC, GH1, GH2, GHRH, GHRHR
3
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10.5GHRH, GH2, GH1, IGF1, BTK
4
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10.5GHRH, GH2, GH1, IGF1, BTK
5
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10.5BTK, IGF1, GH1, GH2, GHRH
6
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10.5BTK, IGF1, GH1, GH2, GHRH
7
Hide members
10.5GHRH, GH2, GH1, IGF1, BTK
8
Hide members
10.5GHRH, GH2, GH1, IGF1, BTK
9
Hide members
10.5GH2, GH1, IGF1, BTK
10
Hide members
10.5GHRHR, GHSR, GHRL, GHRH, GH2, GH1
11
Hide members
10.5GHRHR, GHSR, GHRL, GHRH, GH2, GH1
12
Hide members
10.5GHRH, GH2, GH1, IGF1

Compounds for genes affiliated with Growth Hormone Deficiency

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44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Growth Hormone Deficiency according to GeneCards/GeneDecks:

(show top 50)    (show all 87)
idCompoundScoreTop Affiliating Genes
1hexarelin44 2811.9POMC, GHRH, GHRL, GHSR, IGF1, GH1
2ghrp4410.9GHSR, GHRHR, GHRL, GHRH, GH1, IGF1
3ribonucleic acid4410.9GHSR, IGFBP3, POMC, POU1F1, IGF1, GH1
4acth4410.9GHRL, IGFBP3, GHRH, GH1, PROP1, IGF1
5octreotide44 59 28 1113.9LSL, GHSR, GHRL, GHRH, GH1, IGFBP3
6pyridostigmine44 1111.9IGF1, GHRL, IGFBP3, GHRH, GH1
7lanreotide44 2811.9GHSR, GHRH, GH1, IGFBP3, IGF1
8gnrh4410.9IGFBP3, PROP1, GH1, GHRL, HESX1, LSL
9pegvisomant44 1111.9GHRH, GH1, IGFBP3, IGF1, GHRL
10bromocriptine28 44 1112.9POMC, IGFBP3, POU1F1, GHRH
11triiodothyronine4410.9LSL, GHRL, IGFBP3, GH1, GHRH, POMC
12arginine4410.9GHRH, GHRL, IGFBP3, GH1, BTK, LSL
13naltrexone44 49 28 1113.9POMC, IGF1, IGFBP3, GH1, GHRH
14acipimox44 2811.9GHRH, GHRL, LSL, IGF1, GH1
15dehydroepiandrosterone sulfate4410.9POMC, IGF1, IGFBP3, GH1, GHRL, LSL
16dexamethasone44 49 28 1113.9GHRHR, POMC, POU1F1, GHRL, GHSR, LSL
17testosterone44 59 11 2413.9PROP1, GH1, GH2, GHRH, GHRL, GHSR
18oxandrolone44 1111.9GHRL, GH1, IGFBP3, IGF1
19thyroxine44 2411.9LSL, GHRL, GHRH, GH1, IGFBP3, IGF1
20dhea4410.9IGF1, POMC, IGFBP3, GH1, GHRL, LSL
21estradiol44 11 2412.9GHSR, LSL, POMC, IGF1, IGFBP3, GH1
22steroid4410.9POMC, POU1F1, IGF1, IGFBP3, PROP1, GH1
23clonidine44 28 1112.9GH1, IGFBP3, GHRH, POMC, IGF1
24hydrocortisone44 2 59 1113.9GHSR, IGF1, GH1, GHRL, LSL, POMC
25glucose4410.8POMC, IGF1, IGFBP3, GH1, GH2, GHRL
26pirenzepine44 28 1112.8GHRL, GHRH, GH1, IGF1
27metformin44 49 1112.8POMC, IGF1, GH1, GHRL, LSL
28forskolin44 49 1112.8POMC, GHRH, POU1F1, GHSR, GHRHR
29c-peptide4410.8IGFBP3, LSL, GHRL, GH1, IGF1
30androstenedione44 2411.8IGFBP3, POMC, IGF1, GH1, LSL
31dopamine44 28 11 2413.8IGF1, GHRL, GHSR, GHRH
32deoxypyridinoline4410.8IGF1, IGFBP3, LSL, GH1
33vitamin d4410.8GHRH, GHRL, GH1, IGFBP3, IGF1, POU1F1
34adenylate4410.8GHRL, POMC, GHSR, IGFBP3, GH1, GHRH
35methimazole44 2 1112.8POMC, LSL, IGFBP3, IGF1
36norepinephrine44 11 2412.8POMC, GHRH
37naloxone44 49 28 1113.8GHRH, GHRL, POMC, GH1
38progesterone44 59 28 11 2414.7POU1F1, POMC, IGF1, IGFBP3, GH1, GHRH
39raloxifene44 28 49 1113.7LSL, GH1, IGF1, IGFBP3
40opiate4410.7GH1, GHRH, GHRL, POMC
41megestrol acetate4410.7IGFBP3, IGF1, POMC
42serine4410.7GHRH, GH1, POMC, PROP1, GHRL
43fenfluramine28 44 1112.6GHRH, IGFBP3, POMC
44intralipid4410.6GH1, GHRL, LSL
45epinephrine44 11 2412.6LSL, GHRL, GH1, IGFBP3, POMC
46creatinine4410.5POMC, IGF1, GHRL, LSL, GH1, IGFBP3
47cortisone44 2411.5POMC, IGF1, GH1
48clomiphene citrate4410.5GH1, IGFBP3, IGF1
49corticosterone44 59 2412.4GH1, LSL, GHRL, POMC
50alanine4410.2SOX3, GH1, POMC, LSL, POU1F1, GHRL

GO Terms for genes affiliated with Growth Hormone Deficiency

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16Gene Ontology
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Cellular components related to Growth Hormone Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor binding protein complexGO:01694210.5IGF1, IGFBP3
2secretory granule lumenGO:03477410.5POMC, GHRL
3extracellular regionGO:00557610.4CSHL1, GHRL, GHRH, GH2, GH1, IGFBP3
4extracellular spaceGO:00561510.2GHRL, GHRH, GH1, IGFBP3, IGF1, POMC

Biological processes related to Growth Hormone Deficiency according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.8IGF1, IGFBP3, GH1, GHRH, GHSR, GHRHR
2positive regulation of multicellular organism growthGO:04001810.8GHRHR, GHSR, GHRL, GHRH, GH1, POU1F1
3growth hormone secretionGO:03025210.8GHRHR, GHSR, GHRL, GHRH
4positive regulation of growth hormone secretionGO:06012410.8GHRH, GHRL, GHRHR
5somatotropin secreting cell developmentGO:06013310.7POU1F1, GHRHR
6positive regulation of appetiteGO:03210010.7GHSR, GHRL
7water homeostasisGO:03010410.7IGF1, GHRHR
8negative regulation of tumor necrosis factor biosynthetic processGO:04253610.7GHRL, GHSR
9negative regulation of interleukin-6 biosynthetic processGO:04540910.7GHSR, GHRL
10negative regulation of interleukin-1 beta productionGO:03269110.7GHRL, GHSR
11response to foodGO:03209410.6GHRH, GHSR
12adult feeding behaviorGO:00834310.6GHSR, GHRL
13actin polymerization or depolymerizationGO:00815410.5GHRL, GHSR
14determination of adult lifespanGO:00834010.5POU1F1, GHRHR
15decidualizationGO:04669710.5GHRL, GHSR
16positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.4GH1, IGF1
17cell fate specificationGO:00170810.2POU1F1, OTX2

Molecular functions related to Growth Hormone Deficiency according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth hormone-releasing hormone receptor activityGO:01652010.5GHSR, GHRHR
2hormone activityGO:00517910.4POMC, IGF1, GH1, GH2, CSHL1
3growth hormone-releasing hormone activityGO:01660810.2GHRH, GHRL

Products for genes affiliated with Growth Hormone Deficiency

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  • Antibodies
  • Proteins
  • Lysates
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Sources for Growth Hormone Deficiency

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet