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Growth Hormone Deficiency malady
102 genes, 11 tissues, 892 related diseases, 27 phenotypes, 364 articles, clinical trials.

Summaries for Growth Hormone Deficiency

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30NIH Rare Diseases, 44Wikipedia, 22MalaCards
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NIH Rare Diseases: Growth hormone deficiency is characterized by abnormally short height due to lack (or shortage) of growth hormone. It can be congenital (present at birth) or acquired. Most of the time, no single clear cause can be identified. Most cases are identified in children. Although it is uncommon, growth hormone deficiency may also be diagnosed in adults. Too little growth hormone can cause short stature in children, and changes in muscle mass, cholesterol levels, and bone strength in adults. In adolescents, puberty may be delayed or absent. Treatment involves growth hormone injections. 30

MalaCards: Growth Hormone Deficiency, also known as somatotropin deficiency, is related to isolated growth hormone deficiency and isolated growth hormone deficiency, type ia. An important gene associated with Growth Hormone Deficiency is GH1 (growth hormone 1), and among its related pathways are Type II diabetes mellitus and Glioma Invasiveness. The compounds 25-hydroxyvitamin d and 2-deoxyglucose have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and bone marrow, and related mouse phenotypes are hematopoietic system and endocrine/exocrine gland.

Wikipedia: Growth hormone deficiency (GHD) is a medical condition, caused by problems arising in the pituitary...44 more...

Aliases & Descriptions for Growth Hormone Deficiency

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30NIH Rare Diseases, 32Novoseek , 43UMLS
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growth hormone deficiency 30 32
somatotropin deficiency 43

Related Diseases for Growth Hormone Deficiency

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13GeneCards, 14GeneDecks
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Diseases related to growth hormone deficiency by text searches and GeneDecks gene sharing:

(show top 50)    (show all 889)
idRelated DiseaseScoreTop Affiliating Genes
1isolated growth hormone deficiency37.8BTK, PAX6, LHX4, CD79A, CD40LG, IGF1
2isolated growth hormone deficiency, type ia33.3IGF1, CSH1, CSHL1
3prader-willi syndrome31.3RETN, LEP, LEPR, INS, IGFBP1, IGFBP3
4laron syndrome31.3INS, IGFBP1, IGF2, IGFBP2, IGFBP3, IGF1
5myelomeningocele31.2BGLAP, LEP, IGFBP3, IGF1, GNRH1, PRL
6acute lymphoblastic leukemia31.1BTK, PBX1, LEPR, APOB, IGFBP1, IGFBP2
7turner syndrome30.5SERPINA7, BGLAP, XDH, IGFBP1, IGFBP3, IGF1
8craniopharyngioma30.2LEP, INS, IL6, IGF1R, IGF1, CALCA
9anophthalmia30.2PAX6, LHX4, INS, OTX2, SRY, HESX1
10empty sella syndrome30.1INS, IGFBP3, PRL, POMC
11agammaglobulinemia30.1SH2D1A, BTK, CD79A, CD40LG
12acid-labile subunit30.0APOA1, IGFBP1, IGF2, IGFBP2, IGFBP3, IGF1
13robinow syndrome29.9IGF1, GNRH1, GH1
14dwarfism29.8LHX3, INS, IGFBP1, IGFBP3, IGF1, GH1
15pituitary hormone deficiency29.8PBX1, LHX3, LHX4, INS, IGFBP3, IGF1
16eating disorder29.7RETN, LEP, LEPR, IGFBP2, GHRL, CRH
17adrenocorticotropic hormone deficiency29.7ALB, GHRH, CRH, POMC
18functioning pituitary adenoma29.5LEP, IGF1, GNAS, GNRH1, GH1, GHR
19pseudohypoparathyroidism29.3REN, BGLAP, IGF1, GNAS, CALCA, GH1
20insulin resistance29.3LEPR, INS, SOD1
21septooptic dysplasia29.0LHX3, GH1, HESX1, PROP1, SOD1, POU1F1
22short stature29.0REN, PBX1, BGLAP, LHX3, LHX4, LEP
23hypothyroidism28.9RETN, LPA, LEP, CETP, APOB, IGFBP3
24pituitary tumor28.5VIP, PBX1, LEPR, IGF1, GNAS, GNRH1
25combined pituitary hormone deficiency28.4PBX1, LHX3, LHX4, INS, IGFBP3, IGF1
26hypogonadotropism28.4BGLAP, LHX3, LEP, LEPR, CD36, INS
27lactic acidosis27.9BGLAP, INS, IGF1, F2, ALB, CALCA
28deep vein thrombosis27.8SERPINE1, F2, TNF, PROC, EPO
29hypopituitarism27.4PBX1, LHX3, LHX4, LEP, INS, IL6
30acromegaly26.6RETN, SERPINE1, VIP, LPA, LPL, PBX1
31nonalcoholic steatohepatitis25.8RETN, SERPINE1, LPA, LPL, LEP, LEPR
32cerebral palsy25.8SELE, SERPINE1, BGLAP, LEP, CD79A, CD36
33lipodystrophy25.1RETN, SERPINE1, LPA, LPL, LIPE, LEP
34traumatic brain injury24.9RETN, LEP, MMP9, INS, IL6, APOE
35hypoglycemia24.6LPL, LEP, CD79A, CD36, INS, INSR
36wilson disease24.5XDH, CD79A, IL6, APOE, IGF1, F2
37myopathy23.9SELE, LEP, CD79A, CD40LG, MMP9, INS
38brain injury23.7RETN, SERPINE1, BGLAP, LEP, LEPR, XDH
39hypogonadism23.6RETN, SERPINE1, PBX1, BGLAP, LHX3, LEP
40pituitary adenoma23.1SERPINA7, VIP, PBX1, LEP, LEPR, CD36
41lymphoblastic leukemia22.7BTK, SERPINE1, NAT2, LPL, PBX1, BGLAP
42osteoporosis22.4SELE, BGLAP, LEP, LEPR, CD79A, CD36
43thrombosis20.0REN, RETN, SELE, SERPINE1, LPA, BGLAP
44homocysteine19.5REN, RETN, SELE, SERPINE1, NAT2, LPA
45leukemia18.9SH2D1A, REN, RETN, BTK, SELE, SERPINE1
46adenoma18.5REN, RETN, SERPINA7, VIP, NAT2, PBX1
47blindness18.4REN, SELE, SERPINA7, SERPINE1, VIP, LPL
48cholesterol18.3REN, RETN, SELE, SERPINA7, SERPINE1, VIP
49cerebritis18.2REN, SELE, SERPINE1, VIP, LPA, LPL
50obesity17.7REN, RETN, SELE, SERPINE1, VIP, LPA

Graphical network of the top 20 diseases related to growth hormone deficiency:



Graphical network of diseases related to growth hormone deficiency

Clinical Features for Growth Hormone Deficiency

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Drugs & Therapeutics for Growth Hormone Deficiency

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Genetic Tests for Growth Hormone Deficiency

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Anatomical Context for Growth Hormone Deficiency

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22MalaCards
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MalaCards organs/tissues related to growth hormone deficiency:

22
Brain, Skin, Bone marrow, Skeletal muscle, Thyroid, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Pituitary

Phenotypes for genes affiliated with Growth Hormone Deficiency

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25MGI
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MGI Mouse Phenotypes related to growth hormone deficiency:

25 (show all 27)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1hematopoietic system phenotypeMP:000539710.1SH2D1A, BTK, IGF2, PTH, SRSF2, POU1F1
2endocrine/exocrine gland phenotypeMP:00053799.8POU1F1, SOX3, PROP1, LHX3, LHX4, XDH
3embryogenesis phenotypeMP:00053809.4SLC7A7, PRL, HK2, HESX1, ALPP, F2
4no phenotypic analysisMP:00030129.3IGF2, INS, GNAS, HSD11B2, GHRL, GHSR
5respiratory system phenotypeMP:00053889.2TRPS1, OTX2, CRH, ACHE, HESX1, STAT5B
6craniofacial phenotypeMP:00053828.9PAX6, PBX1, ACHE, LHX3, IGF1R, GNAS
7integument phenotypeMP:00107718.5BTK, LIPE, PBX1, PAX6, LEPR, XDH
8renal/urinary system phenotypeMP:00053678.3REN, CLCN5, PBX1, PAX6, LEPR, LCAT
9nervous system phenotypeMP:00036318.2LHX4, CD36, MMP2, INS, INSR, IGF2
10hearing/vestibular/ear phenotypeMP:00053778.1HESX1, CYP19A1, OTX2, CALCA, GNAS, IGF1R
11limbs/digits/tail phenotypeMP:00053718.1LEP, GNAS, IGF2, PTH, GHRHR, GHR
12tumorigenesisMP:00020067.7IGF1R, PRL, IGF1, GNRH1, TNF, CYP1A2
13liver/biliary system phenotypeMP:00053707.6IL6, APOA1, APOB, IGFBP1, HSD11B1, GH1
14reproductive system phenotypeMP:00053897.4GHRH, GHRHR, TNF, OTX2, SRY, PLTP
15skeleton phenotypeMP:00053907.3IGF2, IGF1, GNAS, GNRH1, CALCA, GHRHR
16normal phenotypeMP:00028737.1CORT, HESX1, HK2, STAT5B, SLC20A1, EPO
17digestive/alimentary phenotypeMP:00053817.1MMP9, CD36, LEPR, INS, INSR, APOE
18adipose tissue phenotypeMP:00053757.0XDH, CYP19A1, ACHE, STAT5B, POMC, SLC2A4
19immune system phenotypeMP:00053876.8SH2D1A, PTH, CYP1A2, CYP19A1, SRSF2, CRH
20behavior/neurological phenotypeMP:00053866.8IGF1R, IGF2, GNAS, HSD11B2, HSD11B1, CALCA
21vision/eye phenotypeMP:00053916.5SOD1, SELE, IL6, HESX1, PLTP, PAX6
22growth/size phenotypeMP:00053786.3IL6, CYP19A1, SST, CRH, CORT, ACHE
23mortality/agingMP:00107686.2LPL, TRPS1, PTH, OTX2, CYP1A2, SRSF1
24muscle phenotypeMP:00053695.1ADIPOQ, APOE, IGF2, IGFBP3, IGF1, GNAS
25cellular phenotypeMP:00053844.2BTK, GNAS, CD36, CD79A, XDH, UCP3
26cardiovascular system phenotypeMP:00053853.2INSR, IL6, APOA1, APOB, APOE, IGF1R
27homeostasis/metabolism phenotypeMP:00053761.3CD36, SELE, SERPINE1, VIP, POU1F1, POMC

Publications for genes affiliated with Growth Hormone Deficiency

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35PubMed
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Articles related to growth hormone deficiency:

(show top 50)    (show all 364)
idTitleAuthorsYearAffiliating Genes
1Genetic polymorphisms in the locus control region and promoter of GH1 are related to serum IGF-I levels and height in patients with isolated growth hormone deficiency and healthy controls. (20190537)de Graaff L.C.... Hokken-Koelega A.C.2010IGF1, GH1
2The accuracy of the glucagon test compared to the ins ulin tolerance test in the diagnosis of adrenal insufficiency in young children with growth hormone deficiency. (20350939)di Iorgi N.... Maghnie M.2010INS
3Cardiac functional reserve is diminished in growth hormone-deficient adults. (19207478)Moisey R.... Tan L.B.2009GH1
4Recessive isolated growth hormone deficiency and muta tions in the ghrelin receptor. (19789204)Pantel J.... Amselem S.2009GHSR
5A recurrent signal peptide mutation in the growth hor mone releasing hormone receptor with defective translocation to the cell surfac e and isolated growth hormone deficiency. (19622623)Godi M.... Giordano M.2009GHRHR, GHRH
6Insulin-like growth factor I and growth responses dur ing the first year of growth hormone treatment in KIGS patients with idiopathic growth hormone deficiency, acquired growth hormone deficiency, turner syndrome and born small for gestational age. (19153504)Cutfield W.S.... Lundgren F.2009IGF1
7Combined growth hormone-releasing hormone and growth hormone-releasing peptide-6 test for the evaluation of growth hormone secretion in children with growth hormone deficiency and growth hormone neurosecretory d ysfunction. (18772594)Spiliotis B.E.... Casanueva F.F.2008GHRH
8Growth hormone therapy does not alter the insulin-like growth factor-I/insulin-like growth factor binding protein-3 molar ratio in growth hormone-deficient children. (18362507)ScirA" G.... Cianfarani S.2008IGF1, IGFBP3
9Long-term effects of growth hormone replacement therapy on thyroid function in adults with growth hormone deficiency. (19012473)Losa M.... Lanzi R.2008IGF1
10Update on epidemiology, etiology, and diagnosis of adult growth hormone deficiency. (19020378)Prodam F.... Aimaretti G.2008IGF1
11Acute ghrelin response to intravenous dexamethasone administration in idiopathic short stature or isolated idiopathic growth hormone-deficient children. (18401204)Radetti G.... Bona G.2008IGF1, GHRL, GH1
12Growth hormone deficient patients after traumatic brain injury--baseline characteristics and benefits after growth hormone replacement--an analysis of the German KIMS database. (18829359)Kreitschmann-Andermahr I.... Wallaschofski H.2008IGF1
13Rescue of pituitary function in a mouse model of isol ated growth hormone deficiency type II by RNA interference. (18006625)Shariat N.... Patton J.G.2008GH1
14Growth hormone levels in the diagnosis of growth hormone deficiency in adulthood. (17429591)Corneli G.... Ghigo E.2007IGF1
15Hemizygosity for chromosome 2q14.2-q22.1 spanning the GLI2 and PROC genes associated with growth hormone deficiency, polydactyly, deep vein thrombosis and urogenital abnormalities. (16650085)Gustavsson P.... Dahl N.2006PROC
16Diagnosis of idiopathic growth hormone deficiency: contributions of data on the acid-labile subunit, insulin-like growth factor (IGF)-I and-II, and IGF binding protein-3. (16759033)Trivin C.... Brauner R.2006IGF1, IGF2, IGFBP3
17Evaluation of final height in patients with pituitary growth hormone deficiency who were treated with growth hormone replacement (16704859)Korpal-Szczyrska M.... NiedA_wiecki M.2006INS
18A novel deletion in the GH1 gene including the IVS3 branch site responsible for autosomal dominant isolated growth hormone deficiency. (16368751)Vivenza D.... Giordano M.2006GH1
19Adiponectin, leptin, and erythrocyte sodium/lithium countertransport activity, but not resistin, are related to glucose metabolism in growth hormone-deficient adults. (15634721)Svensson J.... Johannsson G.2005IGFBP1, RETN, LSL
20Growth hormone replacement is important for the restoration of parathyroid hormone sensitivity and improvement in bone metabolism in older adult growth hormone-deficient patients. (15741264)White H.D.... Vora J.P.2005GHR, PTH
21Characteristics of adult patients with growth hormone deficiency who underwent neurosurgery for functioning and non-functioning pituitary adenomas and craniopharyngiomas. (15887862)Baldelli R.... De Marinis L.2005IGF1
22Are factors at diagnosis of growth hormone deficiency in childhood associated with persistence of growth hormone deficiency into adult life? (16355807)Banerjee I.... Gregory J.W.2005GH1
23Evaluation of adrenal function in patients with growth hormone deficiency and hypothalamic-pituitary disorders: comparison between insulin-induced hypoglycemia, low-dose ACTH, standard ACTH and CRH stimulation tests. (15879359)Maghnie M.... Loche S.2005POMC, CRH
24Long-term monitoring of insulin-like growth factor I in adult growth hormone deficiency: a critical appraisal. (15761235)Gibney J.... Johannsson G.2004IGF1
25Psychological functioning after growth hormone therapy in adult growth hormone deficient patients: endocrine and body composition correlates. (15299990)Lasaite L.... Lasas L.2004IGF1, INS
26Isolated growth hormone deficiency in Chilean patients: clinical and molecular analysis. (14594175)Molina G.... Carvallo P.2003GHSR, GH1, GHRH
27Effects of short- and long-term growth hormone replacement on lipoprotein composition and on very-low-density lipoprotein and low-density lipoprotein apolipoprotein B100 kinetics in growth hormone-deficient hypopituitary subjects. (12524662)Kearney T.... Johnston D.G.2003GHR
28The effectiveness of arginine + GHRH test compared with GHRH + GHRP-6 test in diagnosing growth hormone deficiency in adults. (12864804)Popovic V.... Casanueva F.F.2003GH1, GHRH
29An exonic mutation of the GH-1 gene causing familial isolated growth hormone deficiency type II. (12000366)Takahashi I.... Takada G.2002GH1
30Diagnostic value of serum insulin-like growth factor binding protein-3 in children with or without growth hormone deficiency. (12901539)Qin S.... Deng J.2002IGFBP3
31Delayed growth due to growth hormone deficiency (stu dy of 16 cases) (12534042)Hachicha M.... Triki A.2002GH1
32Plasma levels of insulin-like binding protein-2 in prepubertal short children and its diagnostic value in the evaluation of growth hormone deficiency. (11549877)Van Doorn J.... van Buul-Offers S.C.2001IGFBP2, GH1
33Isolated growth hormone deficiency in children and adolescents. (11529396)Argente J.... Skordis N.2001SLC20A1
34IGFBP-3 as a predictor of growth hormone deficiency. (10722411)Bielinski B.... Clark P.M.2000IGFBP3
35Is there growth hormone deficiency in prader-willi Syndrome? Six arguments to support the presence of hypothalamic growth hormone deficiency in Prader-Willi syndrome. (10971104)Eiholzer U.... L'allemand D.2000IGF1, GH1
36Familial growth hormone deficiency with mutated GHRH receptor gene: clinical and hormonal findings in homozygous and heterozygous individuals from Itabaianinha. (10822217)Hayashida C.Y.... Wajchenberg B.L.2000IGF1, IGFBP3, PRL
37Serum IGF-I and IGFBP-3 concentrations do not accurately predict growth hormone deficiency in children with brain tumours. (10469014)Weinzimer S.A.... Moshang T.1999IGF1, IGFBP3
38Hereditary isolated growth hormone deficiency caused by GH1 gene mutations in Japanese patients. (10549303)Kamijo T.... Ogawa M.1999GH1
39Absence of proteolysis of insulin-like growth factor binding protein-3 in serum from patients with growth hormone deficiency. (10670759)Yamada M.... Hasegawa Y.1999IGFBP3, GHR
40GH substitution does not alter the pulsatile pattern of LH in amenorrhoeic growth hormone deficient women. (10583316)de Boer J.A.... Schoemaker J.1999GH1
41Effect of long-term growth hormone treatment on carbo hydrate metabolism in children with growth hormone deficiency. (9797856)Seminara S.... Loche S.1998INS
42Growth hormone therapy for adult growth hormone deficiency. (9624793)Shalet S.M.1998INS
43Adult height in 24 patients treated for growth hormone deficiency and early puberty. (8989264)Adan L.... Brauner R.1997GNRH1
44Growth hormone substitution in growth hormone-deficie nt adults: effects on collagen type I synthesis and skin thickness. (8886750)Kann P.... Beyer J.1996CD36
45Effects of 1 year of growth hormone therapy on serum lipoprotein levels in growth hormone-deficient adults. Influence of gender and Apo(a) and ApoE phenotypes. (7489235)Johannsson G.... Bengtsson B.A.1995IGF1, APOE
46Interactions of body fat and muscle mass with substrate concentrations and fasting insulin levels in adults with growth hormone deficiency. (7924165)Salomon F.... SAPnksen P.H.1994INS
47Clinical utility of insulin-like growth factor binding protein-3 in the evaluation and treatment of short children with suspected growth hormone deficiency. (7518726)Hasegawa Y.... Yokoya S.1994IGF1, IGFBP3
48Effects of growth hormone and IGF-I on glomerular ultrafiltration in growth hormone-deficient rats. (8265813)Hirschberg R.1993IGF1
49Treatment of isolated growth hormone deficiency type IA due to GH-I gene deletion with recombinant human insulin-like growth factor I. (7509217)Nishi Y.... Hasegawa T.1993IGF1
50Thymic endocrine activity in children with idiopathic growth-hormone deficiency. (1774134)Mocchegiani E.... Paolucci P.1991GGH

Expression for genes affiliated with Growth Hormone Deficiency

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Growth Hormone Deficiency

Pathways for genes affiliated with Growth Hormone Deficiency

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20KEGG, 36QIAGEN, 37R&D Systems, 10EMD Millipore, 41Thomson Reuters, 38Reactome, 34PharmGKB, 3Cell Signaling Technology
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Pathways related to growth hormone deficiency according to GeneDecks:

(show top 50)    (show all 76)
idPathwayScoreTop Affiliating Genes
1Type II diabetes mellitus2010.7ADIPOQ, SLC2A4, INS
2Glioma Invasiveness3610.6GHRH, GNRH1, GH1, GH2
3Adipocytokines & Insulin Signaling3710.5LEP, INS, INSR, SLC2A4, ADIPOQ, RETN
4Growth Hormone Signaling3610.4SLC2A4, IGF1R, IGF2, IGF1, GH1, GHR
5Development IGF-RI signaling1010.4IGF1, IGFBP3, IGFBP2, IGFBP1, IGF1R, IGF2
6Development_IGF-1 receptor signaling4110.4IGFBP3, IGF1R, IGF1, IGFBP2, IGF2, IGFBP1
7Class B/2 (Secretin family receptors)3810.4CRH, GHRHR, GHRH, GNAS, PTH, CALCA
8Selected targets of C/EBPbeta1010.3CETP, APOB, UCP3, RETN
9Caffeine metabolism2010.3XDH, CYP2A6, NAT2, CYP1A2
10Caffeine Pathway, Pharmacokinetics3410.3CYP2A6, CYP1A2, XDH, NAT2
11eNOS Signaling3610.3INSR, IGF2, GNRH1, GH2, GHRH, PDK1
12Jak-STAT signaling pathway2010.2EPO, CSH1, PRL, STAT5B, GHR, LEPR
13Telomerase Components in Cell Signaling3610.2IGF1R, IGF1, GNRH1, GH1, GH2, GHRH
14Warfarin Pathway, Pharmacodynamics3410.2BGLAP, F7, F2, PROC
15Paxillin Interactions3610.2GH1, GHRH, GH2, GNRH1, INSR, IGF1
16Neuroactive ligand-receptor interaction2010.2CSH1, PRL, GHSR, GHRHR, GHR, GH2
17Aldosterone-regulated sodium reabsorption2010.2INS, HSD11B2, HSD11B1
18Selected targets of GCR-alpha1010.1UCP3, INS, INSR, IL6, IGFBP1, GHSR
19NFAT in Immune Response3610.1IGF1, GH1, IGF2, IGF1R, BTK, GNRH1
20Glucose / Energy Metabolism310.1ADIPOQ, SLC2A4, HK2, PDK1, IGFBP2, IGF1R
21Adipocytokine signaling pathway2010.0LEPR, ADIPOQ, SLC2A4, POMC, CD36, LEP
22Selected targets of C/EBPalpha109.9CETP, CD36, ALB, ADIPOQ, APOB, RETN
23mTOR Pathway369.9GH2, GH1, GNRH1, IGF1, IGF2, IL6
24IP3 Pathway369.9GHRH, BTK, CD79A, IL6, IGF2, GH1
2514-3-3 Induced Intracellular Signaling369.8GH2, GHRH, GNRH1, IGF1, IGF1R, INSR
26p53 Mediated Apoptosis369.8GH1, IL6, GHRH, GH2, IGF1R, IGF2
27Selected targets of HNF1109.7ALB, PROC, CYP1A2, IGFBP1, APOA1, INS
28PPAR Pathway369.7IGF1R, TNF, GH2, GH1, IGF1, IGF2
29Statin Pathway, Pharmacodynamics349.7LPL, APOA1, LCAT, APOB, APOE, PLTP
30eIF2 Pathway369.7IL6, IGF2, INSR, INS, IGF1, GH1
31Nanog in Mammalian ESC Pluripotency369.6INSR, IL6, IGF1R, IGF2, GH1, IGF1
32Akt Signaling369.6BTK, TNF, IGF1R, IL6, SLC2A4, GH2
33Apoptotic Pathways in Synovial Fibroblasts369.5GNRH1, IL6, GH1, TNF, GHRH, GH2
34Mitochondrial Apoptosis369.5GH1, GH2, GHRH, IL6, IGF1R, IGF2
35Cellular Apoptosis Pathway369.5GH2, TNF, GHRH, IGF2, GH1, GNRH1
36DHA Signaling369.5IGF1R, IGF2, GH2, GH1, GNRH1, IGF1
37GPCR Pathway369.4IGF1R, GH1, GHRH, GH2, STAT5B, IL6
38Cytokine-cytokine receptor interaction209.4GHR, LEPR, LEP, CD40LG, EPO, PRL
39PAK Pathway369.3GH1, IL6, IGF1R, GNRH1, GH2, IGF1
40p70S6K Signaling369.3INSR, GNRH1, INS, IL6, IGF1R, IGF2
41Renin-Angiotensin Pathway369.3IGF1R, GHRH, IGF2, GH2, REN, IL6
42Rap1 Pathway369.3GHRH, GH2, GNRH1, IGF1, IGF2, IGF1R
43Tec Kinases Signaling369.2GNRH1, GH1, IGF1, IGF1R, IGF2, IL6
44Cell adhesion ECM remodeling109.2IGF2, MMP9, MMP2, IGF1, KLK3, IGF1R
45Cell adhesion_ECM remodeling419.2MMP9, IGF1R, IGF2, IGF1, KLK3, MMP2
46Transcription_Role of VDR in regulation of genes involved in osteoporosis419.2CALCA, BGLAP, CYP19A1, PTH, TNF, IL6
47Transcription Role of VDR in regulation of genes involved in osteoporosis109.2CYP19A1, APOE, PTH, TNF, CALCA, BGLAP
48NF-KappaB (p50-p65) Pathway369.1TNF, GH2, GH1, IGF2, GNRH1, IGF1
49JAK-STAT Pathway368.9IGF1, INSR, BTK, GHR, IL6, IGF1R
50Pancreatic Adenocarcinoma368.6IGF1, GNRH1, GH2, GHRH, GH1, INSR

Compounds for genes affiliated with Growth Hormone Deficiency

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32Novoseek , 9DrugBank, 18HMDB, 42Tocris Bioscience, 34PharmGKB
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Compounds related to growth hormone deficiency according to GeneDecks:

(show top 50)    (show all 502)
idCompoundScoreTop Affiliating Genes
125-hydroxyvitamin d32 10.5BGLAP, LEP, ALPP, PTH, ADIPOQ
22-deoxyglucose32 10.2LIPE, INS, INSR, IGF2, IGF1, CALCA
3triiodothyronine32 10.1SERPINA7, LEP, LEPR, UCP3, IGFBP1, IGF2
4lanreotide32 10.1IGFBP1, IGFBP3, IGF1, GH1, GHR, GHRH
5methimazole32 9 9 12.0SELE, SERPINA7, BGLAP, IGFBP3, IGF1, ALPP
6bromocriptine32 9 9 12.0VIP, GNRH1, GH1, GHRH, CYP1A2, SST
7isoproterenol32 9 9 11.9LIPE, INSR, GNAS, GNRH1, GH1, PTH
8pyridostigmine32 9 9 11.9IGFBP1, IGFBP3, IGF1, GH1, GHRH, GHRL
9dehydroepiandrosterone sulfate32 9.8LEP, INS, IGFBP1, IGF2, IGFBP3, IGF1
10clonidine32 9 9 11.8REN, BGLAP, LEP, IGFBP3, IGF1, CALCA
11fatty acid32 9.7RETN, LIPE, LEP, LEPR, LCAT, INS
12acipimox32 9.7LIPE, LEP, UCP3, CETP, INS, APOA1
13gnrh32 9.7SERPINE1, PBX1, LHX3, LEP, LEPR, INS
1417-hydroxyprogesterone32 18 10.4REN, RETN, PBX1, IGFBP1, IGFBP2, GNRH1
15ascorbic acid32 18 10.4BGLAP, LCAT, CD36, CD40LG, MMP2, IGF1R
16raloxifene32 9 9 11.2SERPINA7, SERPINE1, BGLAP, CD36, APOA1, IGF1R
17forskolin32 42 9 9 12.2REN, RETN, VIP, LIPE, IGFBP1, IGF1R
18estradiol32 9 18 9 12.0REN, SERPINA7, SERPINE1, PBX1, LEPR, IGFBP1
19androstenedione32 18 10.0REN, PBX1, LEP, LEPR, INS, IGFBP1
20dihydrotestosterone32 9 18 9 11.9SERPINE1, VIP, LPL, BGLAP, LEP, CD79A
21intralipid32 8.9LPL, LEP, UCP3, LCAT, CETP, APOA1
22pravastatin32 34 9 18 9 12.7SELE, SERPINE1, LPA, LCAT, CETP, IL6
23calcitriol32 42 9 18 9 12.6REN, BGLAP, CD36, IGFBP1, IGF1R, IGFBP2
24losartan32 34 9 9 11.6REN, SELE, SERPINE1, LEP, XDH, CD36
25ly29400232 8.6RETN, SELE, LEP, UCP3, MMP2, MMP9
26estrone32 9 18 9 11.5SERPINA7, LPL, BGLAP, LEP, APOB, IGFBP1
27nitric oxide32 9 18 9 11.5REN, RETN, SELE, NAT2, LPA, LIPE
28dextran sulfate32 8.5SELE, LPL, CETP, CD36, CD40LG, IL6
29octreotide32 42 9 9 11.4VIP, MMP2, INS, INSR, IGFBP1, IGF1R
30acetylcholine32 9 18 9 11.4VIP, LPL, LEP, CD79A, CD40LG, INSR
31nifedipine32 9 9 10.2REN, SELE, SERPINE1, VIP, BGLAP, LEP
32acth32 8.2REN, SERPINA7, VIP, PBX1, LEP, LEPR
33tamoxifen32 34 9 9 10.9SELE, SERPINA7, LPL, BGLAP, LEP, CETP
34heparin32 9 18 9 10.7SERPINE1, LPA, LPL, BGLAP, UCP3, LCAT
35adenylate32 7.7SELE, SERPINE1, VIP, LPL, LIPE, CD40LG
36cysteine32 7.6BTK, NAT2, LPA, BGLAP, LHX3, LEPR
37fenofibrate32 9 9 9.6RETN, SELE, SERPINE1, LPA, LPL, LEP
38folate32 7.4SELE, NAT2, LPA, CD79A, CD40LG, MMP2
39genistein32 9 18 9 9.9BTK, SELE, SERPINE1, LPL, CD36, CD40LG
40vitamin d32 6.8SERPINE1, LPL, BGLAP, LEPR, CD79A, CD36
41norepinephrine32 9 18 9 9.8REN, RETN, SELE, VIP, LPL, LIPE
42thyroxine32 18 7.7REN, RETN, SERPINA7, VIP, LPA, LPL
43atorvastatin32 34 9 18 9 10.7RETN, SELE, SERPINE1, LPA, LPL, LCAT
44arginine32 6.6REN, BTK, SERPINA7, VIP, LPA, PBX1
45simvastatin32 34 42 9 18 9 11.6SELE, SERPINE1, LPA, LPL, BGLAP, LCAT
46cycloheximide32 6.3RETN, SELE, SERPINE1, LPL, LEP, CD36
47testosterone32 9 18 9 8.6SELE, SERPINA7, VIP, LPL, PBX1, BGLAP
48vegf32 5.2REN, RETN, SELE, SERPINE1, VIP, LPA
49serine32 4.8BTK, SELE, SERPINA7, SERPINE1, VIP, LIPE
50lactate32 4.6SELE, VIP, LPL, LIPE, UCP3, XDH

GO Terms for genes affiliated with Growth Hormone Deficiency

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Sources:
12Gene Ontology
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Cellular components related to growth hormone deficiency according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1secretory granuleGO:03014110.3GHRHR, GHRL, APOA1, INS, POMC
2endoplasmic reticulum lumenGO:0057889.5PROC, C19orf10, GHRL, F2, F7, APOB
3very-low-density lipoprotein particleGO:0343619.3LPL, APOE, APOB, APOA1
4high-density lipoprotein particleGO:0343649.3LCAT, APOA1, CETP, APOE
5extracellular spaceGO:0056153.8CD40LG, MMP2, MMP9, INS, IL6, APOA1
6extracellular regionGO:0055763.3POMC, ADIPOQ, EPO, CSHL1, RETN, MMP9

Biological processes related to growth hormone deficiency according to GeneDecks:

(show top 50)    (show all 68)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.9GHSR, GHRHR, GHRH, GH1, IGFBP3, IGF1
2growth hormone secretionGO:03025210.8GHSR, GHRL, GHRHR, GHRH
3positive regulation of multicellular organism growthGO:04001810.8GH1, GHR, GHRH, GHRL, GHSR, GHRHR
4JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039710.8GHR, GH2, STAT5B, CSH1, PRL, GH1
5response to foodGO:03209410.7GHRH, HSD11B2, GHR, GHSR
6positive regulation of growth hormone secretionGO:06012410.6GHRL, GHRH, GHRHR
7positive regulation of activated T cell proliferationGO:04210410.6IGFBP2, IGF2, STAT5B, IGF1
8positive regulation of glycogen biosynthetic processGO:04572510.6IGF1, INS, INSR, IGF2, PTH
9induction of apoptosis by hormonesGO:00862810.6CRH, PTH, SST
10positive regulation of glucose importGO:04632610.6ADIPOQ, PTH, IGF1, INSR, INS
11cellular response to insulin stimulusGO:03286910.5GHRHR, INSR, GHR, GHSR, SLC2A4, ADIPOQ
12lactationGO:00759510.4HK2, PRL, STAT5B, XDH, GHRHR
13positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.4EPO, GHR, GH1, IGF1
14positive regulation of insulin receptor signaling pathwayGO:04662810.4IGF2, INS, LEP
15glucose homeostasisGO:04259310.3ADIPOQ, INSR, INS, PAX6, SERPINE1, SLC2A4
16hormone-mediated signaling pathwayGO:00975510.3GHSR, GHRL, REN, GHR
17lipoprotein biosynthetic processGO:04215810.3APOB, APOA1, LCAT
18glucose metabolic processGO:00600610.3TNF, PDK1, ADIPOQ, GHRL, IGF2, INS
19response to estrogen stimulusGO:04362710.3EPO, SERPINE1, GHRL, GHRHR, F7, BGLAP
20positive regulation of mitosisGO:04584010.2INSR, INS, IGF2, IGF1, TNF
21positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.2GHR, CD36, INS, ADIPOQ, IL6, IGF2
22cholesterol transportGO:03030110.2LCAT, APOB, APOA1, CD36, CETP
23positive regulation of protein kinase B signaling cascadeGO:05189710.1IGF1, F7, TNF, IGF2, INSR, INS
24response to insulin stimulusGO:03286810.1GGH, GHRHR, HSD11B2, UCP3, LEP
25regulation of multicellular organism growthGO:04001410.1IGF1, GHR, SOD1, STAT5B, PRL
26female pregnancyGO:00756510.1LIPE, LEP, IGFBP2, GNAS, GNRH1, HSD11B2
27positive regulation of blood coagulationGO:03019410.1F2, SERPINE1, CD36, F7
28positive regulation of DNA replicationGO:04574010.0INS, INSR, IGF1R, IGF1, EPO
29positive regulation of MAPK cascadeGO:04341010.0LEP, INS, INSR, IL6, IGF2, IGFBP3
30positive regulation of tyrosine phosphorylation of Stat3 proteinGO:04251710.0LEP, GHR, IL6, GH1
31very-low-density lipoprotein particle remodelingGO:0343729.9APOE, CETP, LPL, LCAT
32response to testosterone stimulusGO:0335749.9EPO, INSR, BGLAP, CYP19A1
33high-density lipoprotein particle remodelingGO:0343759.9CETP, LCAT, APOE, APOA1
34negative regulation of inflammatory responseGO:0507289.9ADIPOQ, GHSR, GHRL, APOE, APOA1
35reverse cholesterol transportGO:0436919.8APOA1, APOE, LCAT, CETP
36response to estradiol stimulusGO:0323559.6MMP9, INSR, STAT5B, CYP19A1, GH1, IGFBP2
37cholesterol metabolic processGO:0082039.5LEPR, LEP, APOB, LCAT, CETP, LIPE
38response to glucocorticoid stimulusGO:0513849.5GHR, LCAT, IL6, IGFBP2, HSD11B2, GHRHR
39platelet degranulationGO:0025769.2SOD1, SERPINE1, CD36, APOA1, IGF1, ALB
40cholesterol homeostasisGO:0426329.1APOA1, CETP, LCAT, APOB, APOE
41positive regulation of cell proliferationGO:0082849.1GHRHR, GHRH, F2, VIP, IL6, INSR
42lipoprotein metabolic processGO:0421579.0APOB, LPA, LPL, LCAT, APOA1, CETP
43response to ethanolGO:0454718.8ADIPOQ, GGH, SOD1, STAT5B, GNRH1, INSR
44negative regulation of apoptotic processGO:0430668.8EPO, PROC, TNF, SERPINE1, LHX3, LEP
45lipid metabolic processGO:0066298.6CD36, PLTP, ALB, UCP3, LCAT, CETP
46platelet activationGO:0301688.5SERPINE1, APOA1, SOD1, ALB, F2, IGF1
47anti-apoptosisGO:0069168.4GHRL, F7, IGF1, IGF1R, APOE, CD40LG
48blood coagulationGO:0075968.3APOB, SERPINE1, ALB, F2, F7, SLC7A7
49response to drugGO:0424938.1IGFBP2, REN, SERPINA7, LPL, LIPE, BGLAP
50small molecule metabolic processGO:0442817.1ALB, GNAS, HSD11B1, CYP1A2, CYP2A6, CYP2D6

Molecular functions related to growth hormone deficiency according to GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor II bindingGO:03199510.4IGFBP3, IGFBP2, INSR
2insulin-like growth factor I bindingGO:03199410.2IGFBP2, IGF1R, IGFBP3, INSR
3insulin receptor bindingGO:00515810.1INS, IGF2, IGF1, IGF1R
4insulin-like growth factor receptor bindingGO:00515910.1IGF2, INS, REN, INSR, IGF1
5oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprGO:0167129.8CYP19A1, CYP2A6, CYP1A2
6hormone activityGO:0051799.5INS, PTH, GH2, GH1, CALCA, GNRH1
7growth factor activityGO:0080839.4GH1, IGF1, F2, IGF2, LEP, IL6
8serine-type endopeptidase activityGO:0042529.3LPA, PREPL, PROC, KLK3, F2, F7
9receptor bindingGO:0051029.1SERPINE1, LPL, F7, F2, REN, CALCA
10protein bindingGO:0055153.8GHRHR, GHR, GH1, CALCA, ALB, F2

Sources for Growth Hormone Deficiency

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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