MCID: GRW007
MIFTS: 48

Growth Hormone Deficiency

Categories: Rare diseases, Endocrine diseases

Aliases & Classifications for Growth Hormone Deficiency

MalaCards integrated aliases for Growth Hormone Deficiency:

Name: Growth Hormone Deficiency 50 29 52
Isolated Somatotropin Deficiency 69
Somatotropin Deficiency 69

Classifications:



Summaries for Growth Hormone Deficiency

NIH Rare Diseases : 50 growth hormone deficiency (ghd) is characterized by abnormally short height due to lack (or shortage) of growth hormone. it can be congenital (present at birth) or acquired. most cases are identified in children. although it is uncommon, growth hormone deficiency may also be diagnosed in adults. too little growth hormone can cause short stature in children, and changes in muscle mass, cholesterol levels, and bone strength in adults. most of the time, no single clear cause can be identified but several genetic causes of ghd have been described, such as mutations in the to pou1f1/pit1 , prop1 ghrh and gh1 genes. in adolescents, puberty may be delayed or absent. treatment involves growth hormone injections. last updated: 6/3/2016

MalaCards based summary : Growth Hormone Deficiency, also known as isolated somatotropin deficiency, is related to growth hormone insensitivity, partial and isolated growth hormone deficiency. An important gene associated with Growth Hormone Deficiency is GH1 (Growth Hormone 1), and among its related pathways/superpathways are G-Beta Gamma Signaling and Peptide hormone metabolism. The drugs Clonidine and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and pituitary, and related phenotypes are endocrine/exocrine gland and adipose tissue

Wikipedia : 72 Growth hormone deficiency (GHD) is a medical condition, caused by problems arising in the pituitary... more...

Related Diseases for Growth Hormone Deficiency

Diseases related to Growth Hormone Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 266)
id Related Disease Score Top Affiliating Genes
1 growth hormone insensitivity, partial 31.3 GH1 IGF1 IGFBP3
2 isolated growth hormone deficiency 12.6
3 growth hormone deficiency, isolated, type ia 12.4
4 growth hormone deficiency, isolated, type ii 12.4
5 growth hormone deficiency, isolated, type ib 12.4
6 mental retardation, x-linked, with isolated growth hormone deficiency 12.3
7 cataracts, growth hormone deficiency, sensory neuropathy, sensorineural hearing loss, and skeletal dysplasia 12.2
8 growth hormone deficiency, isolated partial 12.2
9 agammaglobulinemia and isolated hormone deficiency 12.0
10 encephalopathy with intracranial calcification, growth hormone deficiency, microcephaly, and retinal degeneration 12.0
11 isolated growth hormone deficiency, ghrh-related 12.0
12 isolated growth hormone deficiency, type ib, gh1-related 11.9
13 isolated growth hormone deficiency, type ib, ghrhr-related 11.9
14 mental retardation, x-linked, with growth hormone deficiency 11.9
15 septooptic dysplasia 11.6
16 empty sella syndrome 11.2
17 kearns-sayre syndrome 11.1
18 noonan-like syndrome with loose anagen hair 11.1
19 septo-optic dysplasia spectrum 10.9
20 hypotonia-cystinuria syndrome 10.9
21 mental retardation, x-linked, syndromic, borck type 10.9
22 culler-jones syndrome 10.7
23 microphthalmia, syndromic 3 10.7
24 ritscher-schinzel syndrome 1 10.7
25 growth hormone insensitivity with immunodeficiency 10.7
26 osseous heteroplasia, progressive 10.4 GH1 IGF1
27 intermittent squint 10.4 GH1 GHRH
28 glassy cell carcinoma of the cervix 10.4 GH1 GHRH
29 lymphohistiocytoid mesothelioma 10.4 GHRHR HESX1 SOX3
30 insulin-like growth factor i 10.4
31 male genital organ stricture 10.3 GH1 IGFBP3
32 pituitary adenoma, acth-secreting 10.2 GH1 GHSR IGF1
33 scleral staphyloma 10.2 GHRL GHSR
34 small cell lung cancer, childhood 10.2 IGF1 IGFBP3
35 hypopituitarism 10.2
36 dwarfism familial with muscle spasms 10.2 GH1 GHRH GHRHR
37 rolandic epilepsy, mental retardation, and speech dyspraxia 10.2 BTK HESX1 SOX3
38 selenium poisoning 10.2 IGF1 IGFBP3
39 acromegaly 10.2
40 pulmonary large cell neuroendocrine carcinoma 10.1 IGF1 IGFBP3
41 hyperlipoproteinemia, type ib 10.1 IGF1 IGFBP3
42 isolated klippel-feil syndrome 10.1 HESX1 PROP1
43 carcinoma of unknown primary site, childhood 10.1 GHRH IGF1
44 pityriasis rotunda 10.1 GH1 GHRHR HESX1 SOX3
45 turner syndrome 10.1
46 complement receptor deficiency 10.1 HESX1 PROP1
47 hypoglycemia 10.1
48 diencephalic neoplasm 10.1 GH1 GHRH
49 brain injury 10.1
50 glomerulosclerosis, focal segmental, 1 10.0 IGF1 IGFBP3

Graphical network of the top 20 diseases related to Growth Hormone Deficiency:



Diseases related to Growth Hormone Deficiency

Symptoms & Phenotypes for Growth Hormone Deficiency

MGI Mouse Phenotypes related to Growth Hormone Deficiency:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.76 GHRH GHRHR GHRL HESX1 IGF1 IGFBP3
2 adipose tissue MP:0005375 9.65 GHRHR GHRL GHSR IGF1 IGFBP3
3 growth/size/body region MP:0005378 9.61 BTK GHRH GHRHR GHSR HESX1 IGF1
4 homeostasis/metabolism MP:0005376 9.28 GHRH GHRHR GHRL GHSR IGF1 IGFBP3

Drugs & Therapeutics for Growth Hormone Deficiency

Drugs for Growth Hormone Deficiency (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 182)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clonidine Approved Phase 4,Phase 3 4205-90-7 2803
2
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
3 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
4 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
6 Imatinib Mesylate Phase 4 123596
7 Adrenergic Agents Phase 4,Phase 3,Phase 2
8 Adrenergic Agonists Phase 4,Phase 3,Phase 2
9 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 3
10 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2
11 Analgesics Phase 4,Phase 3,Phase 2
12 Antihypertensive Agents Phase 4,Phase 3
13 Autonomic Agents Phase 4,Phase 3,Phase 2
14 Contraceptive Agents Phase 4
15 Estradiol 17 beta-cypionate Phase 4
16 Estradiol 3-benzoate Phase 4
17 Estradiol valerate Phase 4 979-32-8
18 Estrogens Phase 4,Phase 2,Phase 3
19 insulin Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
20 Insulin, Globin Zinc Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
21 Mitogens Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
22 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
23 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
24 Polyestradiol phosphate Phase 4
25 Sympatholytics Phase 4,Phase 3
26 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
27 Growth Hormone-Releasing Hormone Phase 4,Phase 3,Phase 2,Phase 1
28 arginine Nutraceutical Phase 4,Phase 3,Phase 1
29
Zinc Approved Phase 3,Phase 2,Early Phase 1 7440-66-6 32051 23994
30
Hydrocortisone Approved, Vet_approved Phase 2, Phase 3,Early Phase 1 50-23-7 5754 657311
31
Anastrozole Approved, Investigational Phase 2, Phase 3 120511-73-1 2187
32
Benzocaine Approved Phase 3,Phase 2 1994-09-7, 94-09-7 2337
33
Pamidronate Approved Phase 3 40391-99-9 4674
34
Epinephrine Approved, Vet_approved Phase 2, Phase 3 51-43-4 5816
35 Racepinephrine Approved Phase 2, Phase 3
36
Cladribine Approved, Investigational Phase 2, Phase 3 4291-63-8 20279
37
Cytarabine Approved, Investigational Phase 2, Phase 3 147-94-4 6253
38
Indomethacin Approved, Investigational Phase 2, Phase 3 53-86-1 3715
39
Methotrexate Approved Phase 2, Phase 3 1959-05-2, 59-05-2 126941
40
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
41
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
42
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
43
Vinblastine Approved Phase 2, Phase 3 865-21-4 13342 241903
44
Vincristine Approved, Investigational Phase 2, Phase 3 2068-78-2, 57-22-7 5978
45
Lidocaine Approved, Vet_approved Phase 2, Phase 3 137-58-6 3676
46 tannic acid Approved, Nutraceutical Phase 3,Phase 2
47
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 1 59-30-3 6037
48
leucovorin Approved, Nutraceutical Phase 2, Phase 3 58-05-9 143 6006
49 Hypoglycemic Agents Phase 3,Phase 2,Phase 1,Early Phase 1
50 Liver Extracts Phase 3

Interventional clinical trials:

(show top 50) (show all 274)

id Name Status NCT ID Phase Drugs
1 Phase IV Clinical Study of Pegylated Somatropin (PEG Somatropin) to Treat Growth Hormone Deficiency Children Unknown status NCT02314676 Phase 4
2 Growth Hormone and Brain Functioning After Traumatic Brain Injury Unknown status NCT01699308 Phase 4 Genotropin (somatropin)
3 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
4 Status of Growth Hormone/ Insulin-like Growth Factor-1 (GH/IGF-1) Axis and Growth Failure in Ataxia Telangiectasia (AT) Unknown status NCT01052623 Phase 4 Somatropin, Clonidine, L-Arginin-Hydrochloride, Estradiol valerate
5 An Open-label Phase 4 Study to Explore Immunogenicity of the Liquid Formulation of Saizen® in Subjects With Adult Growth Hormone Deficiency (AGHD) Completed NCT01806298 Phase 4 Saizen® solution for injection (referred as Saizen®)
6 Bone Mineral Density (BMD) in Adolescents With Growth Hormone Deficiency (GHD) Completed NCT00097526 Phase 4
7 Endocrine Dysfunction and Growth Hormone Deficiency in Children With Optic Nerve Hypoplasia Completed NCT00140413 Phase 4 Nutropin AQ
8 A Post Marketing Surveillance Study for NutropinAq® in Adults With Growth Hormone Deficiency Completed NCT00455884 Phase 4
9 Liquid Somatropin Formulation in Children With Growth Hormone Deficiency Completed NCT00567385 Phase 4 somatropin
10 Predictive Markers in GHD and TS Children Treated With SAIZEN® Completed NCT00256126 Phase 4 Saizen
11 Anterior Pituitary Hormone Replacement in Traumatic Brain Injury Completed NCT00957671 Phase 4 Human Growth Hormone;Placebo
12 Growth Hormone and Glucose Metabolism Completed NCT00929799 Phase 4 recombinant human Growth Hormone (Genotropin® )
13 First Year Growth Response Associated Genetic Markers Validation Phase IV Open-label Study in Growth Hormone Deficient and Turner Syndrome Pre-pubertal Children: the PREDICT Pharmacogenetics Validation Study Completed NCT01419249 Phase 4
14 IGF1 Generation Test Completed NCT00145457 Phase 4
15 Comparison of a Needle-free Injection Method With a Needle-syringe Injection Method Completed NCT00990340 Phase 4
16 Comparison of Two Growth Hormone Dosing Methods in Adults With Growth Hormone Deficiency Completed NCT00490191 Phase 4 Somatropin
17 Predictive Markers in Chinese Growth Hormone Deficiency (GHD) Children Treated With Saizen® Completed NCT01187550 Phase 4 Recombinant human growth hormone (r-hGH)
18 Is There a Sensibility Increased in the Growth Hormone at Child With Prader-Willi Syndrome? Completed NCT01298180 Phase 4 Growth hormone (Genotonorm® or Omnitrope®)
19 Effect of Somatropin on Left Ventricular Mass in Growth Hormone Deficient Adult Patients Completed NCT01562834 Phase 4 somatropin;placebo
20 A Multicentre, Randomised, Open-label, Controlled Study to Evaluate the Effects of Saizen® on Cardiac Function in Growth Hormone Deficient(GHD) Subjects During the Transition Phase From Childhood to Adulthood Completed NCT01157793 Phase 4 r-hGH;r-hGH
21 GH and Cardiovascular Risk Factors Completed NCT01877512 Phase 4 Change in daily dosage of Growth Hormone
22 Safety and Efficacy of SR-hGH (Sustained-release Human Growth Hormone, Declage Inj.) Completed NCT01605331 Phase 4 sustained-release recombinant human GH (SR-rhGH)
23 Easypod United States User Trial Completed NCT00689260 Phase 4
24 National Cooperative Growth Study (NCGS) of Optimal Nutropin AQ and Nutropin Dosing in Pubertal Growth Hormone-Deficient (GHD) Patients Completed NCT00097513 Phase 4
25 A Study to Optimize Growth Hormone Dosing in Children With Chronic Kidney Disease by Measuring IGF-1 Levels in Blood Completed NCT00212758 Phase 4 Nutropin AQ
26 Growth Hormone and Endothelial Function in Children Completed NCT00373386 Phase 4 growth hormone
27 Effect of 5 Years of GH Replacement on Atherosclerosis Completed NCT00462475 Phase 4 Recombinant Growth Hormone, Genotropin (Pfizer)
28 Epidemiology Study on Insulin-like Growth Factor-1 in Children With Idiopathic Short Stature (EPIGROW Study) Completed NCT00710307 Phase 4
29 Effects of Growth Hormone Administration on Muscle Strength and Body Composition in Men Over 50 Years Old Completed NCT01853566 Phase 4 growth hormone
30 Norditropin NordiFlex® Device Compared to the Device Previously Used by Patients or Parents Completed NCT01245374 Phase 4
31 Clinical Study of Pegylated Somatropin to Treat Children Growth Hormone Deficiency Recruiting NCT02908958 Phase 4
32 Pegylated Somatropin (PEG Somatropin) in the Treatment of Children With Growth Hormone Deficiency Recruiting NCT03249480 Phase 4
33 Pegylated Somatropin (PEG Somatropin) in the Treatment of Children With Growth Hormone Deficiency Recruiting NCT02976675 Phase 4
34 Phase IV Clinical Study of Pegylated Somatropin (PEG Somatropin) to Treat Growth Hormone Deficiency Children (Clinical Trial I) Recruiting NCT02380235 Phase 4
35 Extension Study of Pegylated Somatropin to Treat Growth Retardation Caused by Endogenous Growth Hormone Deficiency in Children Recruiting NCT03290235 Phase 4 PEG-somatropin
36 Body Composition and Adipose Tissue in HIV Recruiting NCT03226821 Phase 4 Tesamorelin
37 Evaluation of the Ease of Use, Preference, and Safety of EutropinPen Inj. Recruiting NCT03015909 Phase 4 Somatropin
38 Transitional Growth Hormone (GH) Use in Growth Hormone Deficient (GHD) Cancer Survivors Recruiting NCT02629926 Phase 4
39 A Post-Marketing Study of the Immunogenicity of Somatropin (Ribosomal Deoxyribo Nucleic Acid [rDNA] Origin) Injection (Nutropin AQ®) in Children With Growth Hormone Deficiency Active, not recruiting NCT02311894 Phase 4 Somatropin
40 Treatment Of Adult Growth Hormone Deficiency After Traumatic Brain Injury Terminated NCT00555009 Phase 4 Genotropin;Placebo
41 A Study to Evaluate the Efficacy of Somatropin in Adults With Growth Hormone Deficiency Caused by Trauma and/or Head Injury Terminated NCT00638053 Phase 4
42 Cardiovascular Effects on Growth Hormone Therapy in Adults With Growth Hormone Deficiency Terminated NCT01698944 Phase 4 somatropin
43 Treatment Of Adult Growth Hormone Deficiency After Traumatic Brain Injury. Withdrawn NCT00432263 Phase 4 Genotropin (PN-180,307) Somatropin
44 Predictive Value of the Insulin-like Growth Factor-1 (IGF-1) Generation Test for the Growth Response to Growth Hormone Treatment (PRED-IGF) Withdrawn NCT01438801 Phase 4 Nutropin [Somatropin (rDNA origin) for injection]
45 Treatment of Children With Insufficient Secretion of Growth Hormone Unknown status NCT00271518 Phase 3 growth hormone (somatropin)
46 Extension Study on Safety of Long-Term Growth Hormone Replacement in Adult Patients With Growth Hormone Deficiency Completed NCT00191360 Phase 3 Somatropin
47 Validation of Macimorelin as a Test for Adult Growth Hormone Deficiency Completed NCT02558829 Phase 3 Macimorelin;Insulin
48 Treatment of Adults With Growth Hormone Deficiency Completed NCT00294619 Phase 3 growth hormone
49 Treatment of Adults With Growth Hormone Deficiency Completed NCT00596037 Phase 3 Growth hormone - LB03002
50 Cool.Click™ Adolescent Transition Study: Study of Saizen® in Subjects With Childhood-onset Growth Hormone Deficiency Completed NCT00109733 Phase 3

Search NIH Clinical Center for Growth Hormone Deficiency

Genetic Tests for Growth Hormone Deficiency

Genetic tests related to Growth Hormone Deficiency:

id Genetic test Affiliating Genes
1 Growth Hormone Deficiency 29

Anatomical Context for Growth Hormone Deficiency

MalaCards organs/tissues related to Growth Hormone Deficiency:

39
Bone, Testes, Pituitary, Brain, Heart, Liver, Endothelial

Publications for Growth Hormone Deficiency

Articles related to Growth Hormone Deficiency:

(show top 50) (show all 1145)
id Title Authors Year
1
Impact of the underlying etiology of growth hormone deficiency on serum IGF-I SDS levels during GH treatment in children. ( 28760908 )
2017
2
Growth hormone therapy for a patient with idiopathic Fanconi syndrome and growth hormone deficiency. ( 28509131 )
2017
3
Possible effects of an early diagnosis and treatment in patients with growth hormone deficiency: the state of art. ( 28915901 )
2017
4
Growth Hormone Deficiency, Basal Encephalocele, and Morning Glory Anomaly. ( 28938928 )
2017
5
Growth-hormone deficiency in mitochondrial disorders. ( 28085676 )
2017
6
Novel AICDA mutation in a case of autosomal recessive hyper-IgM syndrome, growth hormone deficiency and autoimmunity. ( 27789066 )
2017
7
Effect of growth hormone treatment on children with idiopathic short stature and idiopathic growth hormone deficiency. ( 28690991 )
2017
8
Effects of human recombinant growth hormone on exercise capacity, cardiac structure, and cardiac function in patients with adult-onset growth hormone deficiency. ( 28856940 )
2017
9
A heterozygous microdeletion of 20p12.2-3 encompassing PROKR2 and BMP2 in a patient with congenital hypopituitarism and growth hormone deficiency. ( 28586151 )
2017
10
Mutations in KIAA0753 cause Joubert syndrome associated with growth hormone deficiency. ( 28220259 )
2017
11
Assessment of quality of life on 4-year growth hormone therapy in Japanese patients with adult growth hormone deficiency: A post-marketing, multicenter, observational study. ( 28923784 )
2017
12
Genetic Polymorphisms as Predictive Markers of Response to Growth Hormone Therapy in Children with Growth Hormone Deficiency. ( 28806841 )
2017
13
Choroidal thickness measurements in children with isolated growth hormone deficiency. ( 28912516 )
2017
14
Childhood-Onset Adult Growth Hormone Deficiency: Clinical, Hormonal, and Radiological Assessment in a Single Center in China. ( 28719905 )
2017
15
The prevalence of growth hormone deficiency in survivors of subarachnoid haemorrhage: results from a large single centre study. ( 28822018 )
2017
16
A novel de novo germline mutation Glu40Lys in AKT3 causes megalencephaly with growth hormone deficiency. ( 28190287 )
2017
17
The Impact of Growth Hormone Therapy on the Apoptosis Assessment in CD34+ Hematopoietic Cells from Children with Growth Hormone Deficiency. ( 28067847 )
2017
18
Early growth hormone treatment start in childhood growth hormone deficiency improves near adult height: analysis from NordiNet(Ar) International Outcome Study. ( 28780521 )
2017
19
Atypical intraosseous meningioma with growth hormone deficiency and hyperparathyroidism after craniospinal irradiation. ( 28948343 )
2017
20
Glycogen storage disease type IX and growth hormone deficiency presenting as severe ketotic hypoglycemia. ( 28085675 )
2017
21
Short stature and high serum transaminase levels: growth hormone deficiency in a child with Becker muscular dystrophy. ( 28745468 )
2017
22
Growth hormone improves cardiopulmonary capacity and body composition in children with growth hormone deficiency. ( 28938456 )
2017
23
CELSR2, encoding a planar cell polarity protein, is a putative gene in Joubert syndrome with cortical heterotopia, microophthalmia, and growth hormone deficiency. ( 28052552 )
2017
24
Hearing loss in children with growth hormone deficiency. ( 28802353 )
2017
25
Response to Growth hormone deficiency in mitochondrial disorders. ( 28315851 )
2017
26
The rationale and design of TransCon growth hormone for the treatment of growth hormone deficiency. ( 28947559 )
2017
27
Gender has to be taken into account in diagnosing adult growth hormone deficiency by the GHRH plus arginine test. ( 28755537 )
2017
28
Correlation between adrenal function, growth hormone secretion, and insulin sensitivity in children with idiopathic growth hormone deficiency. ( 28819906 )
2017
29
Growth hormone deficiency in treated acromegaly and active Cushing's syndrome. ( 28477735 )
2017
30
Isolated growth hormone deficiency due to the R183H mutation in GH1: Clinical analysis of a four-generation family. ( 28626954 )
2017
31
Type 3 renal tubular acidosis associated with growth hormone deficiency. ( 28888090 )
2017
32
Is insulin-like growth factor-I a good marker for treatment adherence in growth hormone deficiency in adulthood? ( 26824335 )
2016
33
TRABECULAR BONE SCORE CHANGE DIFFERS WITH REGARD TO 25(OH)D LEVELS IN PATIENTS TREATED FOR ADULT-ONSET GROWTH HORMONE DEFICIENCY. ( 27042750 )
2016
34
Prevalence and clinical features of polycystic ovarian syndrome in adolescents with previous childhood growth hormone deficiency. ( 26953707 )
2016
35
Growth hormone and the heart in growth hormone deficiency-what have we learned so far? ( 27981513 )
2016
36
Coexisting Turner's syndrome, Hashimoto's thyroiditis, and growth hormone deficiency. ( 27366729 )
2016
37
Growth Hormone Deficiency in Prepubertal Children: Predictive Markers of Cardiovascular Disease. ( 26960169 )
2016
38
The correlation of leptin/leptin receptor gene polymorphism and insulin-like growth factor-1 and their impact on childhood growth hormone deficiency. ( 27649665 )
2016
39
A novel OTX2 gene frameshift mutation in a child with microphthalmia, ectopic pituitary and growth hormone deficiency. ( 26974134 )
2016
40
Administration of anti-receptor activator of nuclear factor-kappa B ligand (RANKL) antibody for the treatment of osteoporosis was associated with amelioration of hepatitis in a female patient with growth hormone deficiency: a case report. ( 27881164 )
2016
41
Lipid Accumulation Product: a Simple and Accurate Index for Predicting Metabolic Syndrome in Patients with Adult Growth Hormone Deficiency. ( 27123781 )
2016
42
The Relationship Between Gene Polymorphism of Leptin and Leptin Receptor and Growth Hormone Deficiency. ( 26915772 )
2016
43
Growth Hormone Deficiency in a Child with Neurofibromatosis-Noonan Syndrome. ( 26758488 )
2016
44
An audit of the management of childhood-onset growth hormone deficiency during young adulthood in Scotland. ( 26985190 )
2016
45
A Critical Appraisal of Growth Hormone Therapy in Growth Hormone Deficiency and Turner Syndrome Patients in Turkey. ( 27354120 )
2016
46
An examination of the effects of different doses of recombinant human growth hormone on children with growth hormone deficiency. ( 27168784 )
2016
47
Growth hormone replacement therapy reduces risk of cancer in adult with growth hormone deficiency: A meta-analysis. ( 27835910 )
2016
48
Educating children and families about growth hormone deficiency and its management: part 2. ( 26954647 )
2016
49
Cardiovascular Risk in Growth Hormone Deficiency: Beneficial Effects of Growth Hormone Replacement Therapy. ( 27241971 )
2016
50
The visceral adiposity index is associated with insulin sensitivity and IGF-I levels in adults with growth hormone deficiency. ( 27520559 )
2016

Variations for Growth Hormone Deficiency

ClinVar genetic disease variations for Growth Hormone Deficiency:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 ADNP NM_001282531.2(ADNP): c.2188C> T (p.Arg730Ter) single nucleotide variant Pathogenic/Likely pathogenic rs886041116 GRCh37 Chromosome 20, 49509063: 49509063

Expression for Growth Hormone Deficiency

Search GEO for disease gene expression data for Growth Hormone Deficiency.

Pathways for Growth Hormone Deficiency

GO Terms for Growth Hormone Deficiency

Cellular components related to Growth Hormone Deficiency according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 insulin-like growth factor ternary complex GO:0042567 8.96 IGF1 IGFBP3
2 insulin-like growth factor binding protein complex GO:0016942 8.62 IGF1 IGFBP3

Biological processes related to Growth Hormone Deficiency according to GeneCards Suite gene sharing:

(show all 21)
id Name GO ID Score Top Affiliating Genes
1 cell maturation GO:0048469 9.6 BTK GHRHR
2 negative regulation of insulin secretion GO:0046676 9.59 GHRL GHSR
3 pituitary gland development GO:0021983 9.58 HESX1 SOX3
4 cAMP-mediated signaling GO:0019933 9.58 GHRH GHRHR
5 hormone-mediated signaling pathway GO:0009755 9.57 GHRL GHSR
6 decidualization GO:0046697 9.56 GHRL GHSR
7 response to food GO:0032094 9.55 GHRH GHSR
8 positive regulation of multicellular organism growth GO:0040018 9.55 GH1 GHRH GHRHR GHRL GHSR
9 actin polymerization or depolymerization GO:0008154 9.54 GHRL GHSR
10 positive regulation of hormone secretion GO:0046887 9.52 GHRH GHRHR
11 adult feeding behavior GO:0008343 9.51 GHRL GHSR
12 positive regulation of growth hormone secretion GO:0060124 9.5 GHRH GHRHR GHRL
13 negative regulation of interleukin-1 beta production GO:0032691 9.49 GHRL GHSR
14 regulation of insulin-like growth factor receptor signaling pathway GO:0043567 9.48 GHRHR IGFBP3
15 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.46 GHRL GHSR
16 negative regulation of interleukin-6 biosynthetic process GO:0045409 9.43 GHRL GHSR
17 adenohypophysis development GO:0021984 9.43 GHRH GHRHR PROP1
18 positive regulation of appetite GO:0032100 9.4 GHRL GHSR
19 positive regulation of circadian sleep/wake cycle, non-REM sleep GO:0046010 9.37 GHRHR GHRL
20 growth hormone secretion GO:0030252 9.26 GHRH GHRHR GHRL GHSR
21 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.1 GH1 GHRH GHRHR GHSR IGF1 IGFBP3

Molecular functions related to Growth Hormone Deficiency according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.33 GH1 GHRL IGF1
2 growth factor binding GO:0019838 9.32 GHRHR IGFBP3
3 peptide hormone binding GO:0017046 9.26 GHRHR GHSR
4 growth hormone-releasing hormone receptor activity GO:0016520 8.96 GHRHR GHSR
5 growth hormone-releasing hormone activity GO:0016608 8.62 GHRH GHRL

Sources for Growth Hormone Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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