MCID: GRW001
MIFTS: 59

Growth Hormone Secreting Pituitary Adenoma malady

Cancer diseases, Endocrine diseases categories
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Summaries for Growth Hormone Secreting Pituitary Adenoma

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Wikipedia:65 Acromegaly (/? more...

MalaCards based summary: Growth Hormone Secreting Pituitary Adenoma, also known as growth hormone producing adenoma of the pituitary, is related to mccune albright syndrome and acromegaly, and has symptoms including An important gene associated with Growth Hormone Secreting Pituitary Adenoma is AIP (aryl hydrocarbon receptor interacting protein), and among its related pathways are AHR Pathway and TSH signaling pathway. The compounds fluoxetine and quinagolide have been mentioned in the context of this disorder. Affiliated tissues include pituitary, endothelial and bone, and related mouse phenotypes are adipose tissue and limbs/digits/tail.

Description from OMIM:46 102200

Aliases & Classifications for Growth Hormone Secreting Pituitary Adenoma

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Growth Hormone Secreting Pituitary Adenoma, Aliases & Descriptions:

Name: Growth Hormone Secreting Pituitary Adenoma 8
Growth Hormone Producing Adenoma of the Pituitary 8 62
Growth Hormone Secreting Adenoma of Pituitary 8 62
 
Somatotroph Adenoma 8 22
Pituitary Adenoma, Growth Hormone-Secreting 46
Growth Hormone-Secreting Pituitary Adenoma 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


External Ids:

Disease Ontology8 DOID:6255
NCIt39 C7461
SNOMED-CT57 254957009
MeSH34 D049912
OMIM46 102200

Related Diseases for Growth Hormone Secreting Pituitary Adenoma

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Diseases related to Growth Hormone Secreting Pituitary Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 64)
idRelated DiseaseScoreTop Affiliating Genes
1mccune albright syndrome31.2GNAS
2acromegaly31.1PRL, IGF1
3pituitary adenoma31.1AIP, IGF1, GNAS, PRL, RB1
4adenoma31.1AIP, IGF1, GNAS, PRL, RB1
5amenorrhea30.6PRL, IGF1
6gigantism30.1PRL, GNAS, IGF1, AIP
7prolactinoma30.0AIP, IGF1, GNAS, PRL
8pituitary tumors29.8AIP, IGF1, GNAS, PRL, RB1
9somatostatin analog10.6
10endotheliitis10.6
11meningioma10.5
12pituitary apoplexy10.5PRL
13gangliocytoma10.4
14aortitis10.4
15moyamoya disease10.4
16fibrous dysplasia10.4
17adenocarcinoma10.4
18lipomatosis10.4
19neuroendocrine tumor10.4
20papillary thyroid carcinoma10.4
21thyroiditis10.4
22aneurysm10.4
23headache10.4
24neuronitis10.3
25craniopharyngioma10.3PRL, IGF1
26sheehan syndrome10.2IGF1, PRL
27empty sella syndrome10.2IGF1, PRL
28thyrotropin deficiency, isolated10.2PRL, IGF1
29pituitary gland disease10.2PRL, IGF1
30panhypopituitarism10.2IGF1, PRL
31anovulation10.2IGF1, PRL
32growth hormone deficiency10.2PRL, IGF1
33hypopituitarism10.2PRL, IGF1
34wermer syndrome10.2PRL, GNAS
35anorexia nervosa10.2PRL, IGF1
36choristoma10.2
37hypogonadism10.2PRL, IGF1
38polycystic ovary syndrome10.1PRL, IGF1
39retinopathy of prematurity10.1IGF1, VEGFA
40lung cancer10.1VEGFA, IGF1
41laryngeal squamous cell carcinoma10.1RB1, VEGFA
42grade iii astrocytoma10.1VEGFA, RB1
43proliferative diabetic retinopathy10.1VEGFA, IGF1
44hypoglycemia10.1PRL, IGF1
45diabetic retinopathy10.1VEGFA, IGF1
46carney complex10.0GNAS, AIP
47hyperprolactinemia10.0IGF1, GNAS, PRL
48precocious puberty10.0PRL, GNAS, IGF1
49hyperandrogenism10.0PRL, GNAS, IGF1
50cushing's syndrome10.0PRL, GNAS, IGF1

Graphical network of the top 20 diseases related to Growth Hormone Secreting Pituitary Adenoma:



Diseases related to growth hormone secreting pituitary adenoma

Symptoms for Growth Hormone Secreting Pituitary Adenoma

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Symptoms by clinical synopsis from OMIM:

102200

Clinical features from OMIM:

102200

HPO human phenotypes related to Growth Hormone Secreting Pituitary Adenoma:

(show all 12)
id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 coarse facial features HP:0000280
3 hypertension HP:0000822
4 growth hormone excess HP:0000845
5 menstrual irregularities HP:0000858
6 somatic mutation HP:0001428
7 cardiomyopathy HP:0001638
8 left ventricular hypertrophy HP:0001712
9 abnormality of metabolism/homeostasis HP:0001939
10 pituitary adenoma HP:0002893
11 pituitary prolactin cell adenoma HP:0006767
12 galactorrhea HP:0100829

Drugs & Therapeutics for Growth Hormone Secreting Pituitary Adenoma

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Drug clinical trials:

Search ClinicalTrials for Growth Hormone Secreting Pituitary Adenoma

Search NIH Clinical Center for Growth Hormone Secreting Pituitary Adenoma

Genetic Tests for Growth Hormone Secreting Pituitary Adenoma

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Genetic tests related to Growth Hormone Secreting Pituitary Adenoma:

id Genetic test Affiliating Genes
1 Somatotroph Adenoma22

Anatomical Context for Growth Hormone Secreting Pituitary Adenoma

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MalaCards organs/tissues related to Growth Hormone Secreting Pituitary Adenoma:

32
Pituitary, Endothelial, Bone, Colon, Thyroid, Skin

Animal Models for Growth Hormone Secreting Pituitary Adenoma or affiliated genes

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MGI Mouse Phenotypes related to Growth Hormone Secreting Pituitary Adenoma:

36 (show all 18)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.6RB1, GNAS, IGF1
2MP:00053718.3RB1, GNAS, VEGFA, IGF1
3MP:00053778.3RB1, GNAS, IGF1
4MP:00053888.3RB1, GNAS, VEGFA, IGF1
5MP:00053708.2AIP, VEGFA, GNAS, PRL, RB1
6MP:00053698.2IGF1, VEGFA, GNAS, RB1
7MP:00053908.2IGF1, VEGFA, GNAS, RB1
8MP:00028738.1RB1, GNAS, VEGFA, IGF1
9MP:00053898.0IGF1, VEGFA, PRL, RB1
10MP:00053857.9AIP, IGF1, VEGFA, GNAS, RB1
11MP:00020067.9AIP, IGF1, VEGFA, PRL, RB1
12MP:00053787.8RB1, GNAS, VEGFA, IGF1, AIP
13MP:00053877.8IGF1, VEGFA, GNAS, PRL, RB1
14MP:00036317.7IGF1, VEGFA, GNAS, PRL, RB1
15MP:00107687.5AIP, IGF1, VEGFA, GNAS, RB1
16MP:00053797.4RB1, PRL, GNAS, VEGFA, IGF1, AIP
17MP:00107717.4AIP, IGF1, VEGFA, GNAS, PRL, RB1
18MP:00053767.4AIP, IGF1, VEGFA, GNAS, PRL, RB1

Publications for Growth Hormone Secreting Pituitary Adenoma

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Articles related to Growth Hormone Secreting Pituitary Adenoma:

(show top 50)    (show all 62)
idTitleAuthorsYear
1
Treatment protocols for growth hormone-secreting pituitary adenomas combined with craniofacial fibrous dysplasia: A case report of atypical McCune-Albright syndrome. (25120617)
2014
2
Gigantism caused by growth hormone secreting pituitary adenoma. (25077093)
2014
3
Long-term changes in serum IGF-1 levels after successful surgical treatment of growth hormone-secreting pituitary adenoma. (23728452)
2013
4
Growth hormone secreting pituitary adenoma associated with Rathke's cleft cyst. (22824691)
2012
5
Neuroendocrine tumor of unknown origin metastasizing to a growth hormone-secreting pituitary adenoma. (22120409)
2012
6
Spontaneous cerebrospinal fluid rhinorrhea as the initial presentation of growth hormone-secreting pituitary adenoma. (20888068)
2011
7
Management of coexisting thyrotropin/growth-hormone-secreting pituitary adenoma and papillary thyroid carcinoma: a therapeutic challenge. (20067380)
2010
8
Analysis of differential gene expression by bead-based fiber-optic array in growth-hormone-secreting pituitary adenomas. (22993617)
2010
9
Tumor volume of growth hormone-secreting pituitary adenomas during treatment with pegvisomant: a prospective multicenter study. (19965922)
2010
10
Expression of Ki-67, p53 and vascular endothelial growth factor (VEGF) concomitantly in growth hormone-secreting pituitary adenomas; which one has a role in tumor behavior ? (21196926)
2010
11
Elevation of growth hormone secretagogue receptor type 1a mRNA expression in human growth hormone-secreting pituitary adenoma harboring G protein alpha subunit mutation. (20150876)
2010
12
Growth hormone- secreting pituitary adenomas: from molecular basis to treatment options in acromegaly. (20234189)
2010
13
Surgical results of growth hormone-secreting pituitary adenoma. (19516943)
2009
14
The role of stereotactic radiotherapy in patients with growth hormone-secreting pituitary adenoma. (18413424)
2008
15
Low levels of raf kinase inhibitory protein in growth hormone-secreting pituitary adenomas correlate with poor response to octreotide treatment. (18230656)
2008
16
Elevation of growth hormone-releasing hormone receptor messenger ribonucleic acid expression in growth hormone-secreting pituitary adenoma with Gsalpha protein mutation. (19029774)
2008
17
Expression of vascular endothelial growth factor in growth hormone-secreting pituitary adenomas: special reference to the octreotide treatment. (18953743)
2008
18
Prognostic significance of the Ki-67 labeling index in growth hormone-secreting pituitary adenomas. (18460561)
2008
19
Short-lasting, unilateral neuralgiform headache attacks with conjunctival injection and tearing syndrome treated successfully with transsphenoidal resection of a growth hormone-secreting pituitary adenoma. (18590441)
2008
20
MRI finding of simultaneous coexistence of growth hormone-secreting pituitary adenoma with intracranial meningioma and carotid artery aneurysms: report of a case. (17334927)
2007
21
A possible new syndrome with growth-hormone secreting pituitary adenoma, colonic polyposis, lipomatosis, lentigines and renal carcinoma in association with familial testicular germ cell malignancy: A case report. (17411461)
2007
22
Silent growth hormone secreting pituitary adenomas: IGF-1 is not sufficient to exclude growth hormone excess. (17270100)
2007
23
Ectopic suprasellar growth hormone-secreting pituitary adenoma: case report. (17986925)
2007
24
Effect of preoperative use of long-acting octreotide on growth hormone secreting pituitary adenoma and transsphenoidal surgery. (15844307)
2005
25
Stereotactic conformal radiotherapy in patients with growth hormone-secreting pituitary adenoma. (15234043)
2004
26
Sarcomatous change after sellar irradiation in a growth hormone-secreting pituitary adenoma. (14672272)
2003
27
Somatostatin analogs in treatment of non-growth hormone-secreting pituitary adenomas. (12721508)
2003
28
Growth hormone-secreting pituitary adenoma confined to the sphenoid sinus associated with a normal-sized empty sella. (11922715)
2002
29
Expression of cyclic adenosine 3',5'-monophosphate (cAMP)-responsive element binding protein and inducible-cAMP early repressor genes in growth hormone-secreting pituitary adenomas with or without mutations of the Gsalpha gene. (11344215)
2001
30
Ectopic growth hormone-secreting pituitary adenoma in the sphenoid sinus. (11201818)
2001
31
Proliferation, vascular endothelial growth factor expression and cavernous sinus invasion in growth hormone secreting pituitary adenomas. (11214627)
2000
32
Osseous metaplasia in a growth hormone-secreting pituitary adenoma. (10442463)
1999
33
A functional thyrotropin- and growth hormone-secreting pituitary adenoma with a ultrastructurally monomorphic feature: a case study. (9700474)
1998
34
Detection of gsp oncogene in growth hormone-secreting pituitary adenomas and the study of clinical characteristics of acromegalic patients with gsp-positive pituitary tumors. (11189233)
1998
35
Growth hormone-secreting pituitary adenoma associated with multiple bone cysts, skin pigmentation and aortitis syndrome. (9061509)
1996
36
Growth hormone secreting pituitary adenoma: Clinical aspects and surgical outcome. (17587934)
1995
37
Results of the lateral rhinotomy approach in transsphenoidal microsurgery for growth hormone-secreting pituitary adenoma. (8719832)
1995
38
Hormonal and radiological effects of megavoltage radiotherapy in patients with growth hormone-secreting pituitary adenoma. (8258643)
1993
39
Detection of growth hormone, prolactin and human beta-chorionic gonadotropin mRNA in growth hormone-secreting pituitary adenomas and in prolactin-secreting pituitary adenomas by in situ hybridization using a non-isotopic detection method. (8317187)
1993
40
Coexistence of growth hormone-secreting pituitary adenoma and intracranial meningioma: a case report and review of the literature. (8282967)
1993
41
Adenocarcinoma metastatic to a growth-hormone-secreting pituitary adenoma: case report. (1631761)
1992
42
Detection of growth hormone, prolactin and human beta-chorionic gonadotropin messenger RNA in growth-hormone-secreting pituitary adenomas by in situ hybridization. (2058088)
1991
43
Differential response to aminergic stimuli and biological behavior of growth hormone secreting pituitary adenomas. (2107017)
1990
44
Prolactin gene expression in human growth hormone-secreting pituitary adenomas. (2338572)
1990
45
Intrasellar gangliocytoma containing gastrin and growth hormone-releasing hormone associated with a growth hormone-secreting pituitary adenoma. (2512034)
1989
46
Malignant growth hormone-secreting pituitary adenoma with hematogenous dural metastasis: case report. (3047593)
1988
47
Long term treatment with the somatostatin analog SMS 201-995 in a patient with a thyrotropin- and growth hormone-secreting pituitary adenoma. (2895119)
1988
48
Results of transsphenoidal microsurgery for growth hormone-secreting pituitary adenoma in a series of 214 patients. (3373281)
1988
49
Human growth hormone-secreting pituitary adenoma cells in long-term culture: effects of dexamethasone and growth hormone releasing factor. (6421977)
1984
50
Growth hormone-secreting pituitary adenoma in uniovular twin brothers: case report. (7193813)
1981

Variations for Growth Hormone Secreting Pituitary Adenoma

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Clinvar genetic disease variations for Growth Hormone Secreting Pituitary Adenoma:

6 (show all 59)
id Gene Name Type Significance SNP ID Assembly Location
1GNASNM_001077488.2(GNAS): c.604C> T (p.Arg202Cys)single nucleotide variantPathogenicrs11554273GRCh37Chr 20, 57484420: 57484420
2GNASNM_001077488.2(GNAS): c.605G> A (p.Arg202His)single nucleotide variantPathogenicrs121913495GRCh37Chr 20, 57484421: 57484421
3GNASNM_001077488.2(GNAS): c.683A> G (p.Gln228Arg)single nucleotide variantPathogenicrs121913494GRCh37Chr 20, 57484596: 57484596
4GNASNM_001077488.2(GNAS): c.604C> A (p.Arg202Ser)single nucleotide variantPathogenicrs11554273GRCh37Chr 20, 57484420: 57484420
5AIPNM_003977.2: c.-1212_279+578deldeletionLikely pathogenicGRCh37Chr 11, 67249418: 67255234
6AIPNM_003977.2: c.(?_1)_(*_?)deletionLikely pathogenic
7AIPNM_003977.2: c.100-1025_279+357del1562deletionLikely pathogenicGRCh37Chr 11, 67253452: 67255013
8AIPNM_003977.2(AIP): c.138_161del24 (p.Gly47_Arg54del)deletionLikely pathogenicrs267606537GRCh37Chr 11, 67254515: 67254538
9AIPNM_003977.2(AIP): c.166C> A (p.Arg56Ser)single nucleotide variantLikely pathogenicrs267606538GRCh37Chr 11, 67254543: 67254543
10AIPNM_003977.2(AIP): c.174G> C (p.Lys58Asn)single nucleotide variantLikely pathogenicrs267606539GRCh37Chr 11, 67254551: 67254551
11AIPNM_003977.2(AIP): c.241C> T (p.Arg81Ter)single nucleotide variantPathogenicrs267606541GRCh37Chr 11, 67254618: 67254618
12AIPNM_003977.2(AIP): c.244_248delGAAGG (p.Glu82Glyfs)deletionLikely pathogenicrs267606542GRCh37Chr 11, 67254621: 67254625
13AIPNM_003977.2(AIP): c.249G> T (p.Gly83=)single nucleotide variantLikely pathogenicrs104895072GRCh37Chr 11, 67254626: 67254626
14AIPNM_003977.2(AIP): c.250G> A (p.Glu84Lys)single nucleotide variantLikely pathogenicrs267606543GRCh37Chr 11, 67254627: 67254627
15AIPNM_003977.2(AIP): c.280-1G> Asingle nucleotide variantLikely pathogenicrs267606544GRCh37Chr 11, 67256737: 67256737
16AIPNM_003977.2(AIP): c.286_287delGT (p.Val96Profs)deletionLikely pathogenicrs267606545GRCh37Chr 11, 67256744: 67256745
17AIPNM_003977.2(AIP): c.2T> C (p.Met1Thr)single nucleotide variantLikely pathogenicrs267606546GRCh37Chr 11, 67250631: 67250631
18AIPNM_003977.2(AIP): c.308A> G (p.Lys103Arg)single nucleotide variantLikely pathogenicrs267606548GRCh37Chr 11, 67256766: 67256766
19AIPNM_003977.2(AIP): c.350delG (p.Gly117Alafs)deletionLikely pathogenicrs267606549GRCh37Chr 11, 67256808: 67256808
20AIPNM_003977.2(AIP): c.3_4insC (p.Ala2Argfs)insertionLikely pathogenicrs267606547GRCh37Chr 11, 67250632: 67250633
21AIPNM_003977.2(AIP): c.404delA (p.His135Leufs)deletionLikely pathogenicrs267606551GRCh37Chr 11, 67256862: 67256862
22AIPNM_003977.2(AIP): c.424C> T (p.Gln142Ter)single nucleotide variantLikely pathogenicrs267606552GRCh37Chr 11, 67256882: 67256882
23AIPNM_003977.2(AIP): c.468+1G> Asingle nucleotide variantLikely pathogenicrs267606554GRCh37Chr 11, 67256927: 67256927
24AIPNM_003977.2(AIP): c.469-2A> Gsingle nucleotide variantLikely pathogenicrs267606556GRCh37Chr 11, 67257507: 67257507
25AIPNM_003977.2(AIP): c.490C> T (p.Gln164Ter)single nucleotide variantLikely pathogenicrs104895073GRCh37Chr 11, 67257530: 67257530
26AIPNM_003977.2(AIP): c.500delC (p.Pro167Hisfs)deletionLikely pathogenicrs267606557GRCh37Chr 11, 67257540: 67257540
27AIPNM_003977.2(AIP): c.517_521delGAAGA (p.Glu174Glyfs)deletionLikely pathogenicrs267606558GRCh37Chr 11, 67257557: 67257561
28AIPNM_003977.2(AIP): c.550C> T (p.Gln184Ter)single nucleotide variantLikely pathogenicrs267606560GRCh37Chr 11, 67257590: 67257590
29AIPNM_003977.2(AIP): c.584T> C (p.Val195Ala)single nucleotide variantLikely pathogenicrs267606561GRCh37Chr 11, 67257624: 67257624
30AIPNM_003977.2(AIP): c.591G> A (p.Glu197=)single nucleotide variantLikely pathogenicrs202006716GRCh37Chr 11, 67257631: 67257631
31AIPNM_003977.2(AIP): c.601A> T (p.Lys201Ter)single nucleotide variantLikely pathogenicrs267606563GRCh37Chr 11, 67257641: 67257641
32AIPNM_003977.2(AIP): c.646G> T (p.Glu216Ter)single nucleotide variantLikely pathogenicrs267606565GRCh37Chr 11, 67257787: 67257787
33AIPNM_003977.2(AIP): c.649C> T (p.Gln217Ter)single nucleotide variantLikely pathogenicrs267606566GRCh37Chr 11, 67257790: 67257790
34AIPNM_003977.2(AIP): c.662dupC (p.Glu222Terfs)duplicationLikely pathogenicrs104895075GRCh37Chr 11, 67257803: 67257804
35AIPNM_003977.2(AIP): c.70G> T (p.Glu24Ter)single nucleotide variantLikely pathogenicrs267606568GRCh37Chr 11, 67250699: 67250699
36AIPNM_003977.2(AIP): c.713G> A (p.Cys238Tyr)single nucleotide variantLikely pathogenicrs267606569GRCh37Chr 11, 67257854: 67257854
37AIPNM_003977.2(AIP): c.715C> T (p.Gln239Ter)single nucleotide variantLikely pathogenicrs267606571GRCh37Chr 11, 67257856: 67257856
38AIPNM_003977.2(AIP): c.721A> G (p.Lys241Glu)single nucleotide variantPathogenicrs267606573GRCh37Chr 11, 67257862: 67257862
39AIPNM_003977.2(AIP): c.721A> T (p.Lys241Ter)single nucleotide variantLikely pathogenicrs267606573GRCh37Chr 11, 67257862: 67257862
40AIPNM_003977.2(AIP): c.742_744delTAC (p.Tyr248del)deletionLikely pathogenicrs267606574GRCh37Chr 11, 67257883: 67257885
41AIPNM_003977.2: c.74_81delTCCCGGACins7indelLikely pathogenicGRCh37Chr 11, 67250703: 67250710
42AIPNM_003977.2(AIP): c.769A> G (p.Ile257Val)single nucleotide variantLikely pathogenicrs267606575GRCh37Chr 11, 67257910: 67257910
43AIPNM_003977.2(AIP): c.803A> G (p.Tyr268Cys)single nucleotide variantLikely pathogenicrs267606577GRCh37Chr 11, 67258274: 67258274
44AIPNM_003977.2(AIP)duplicationPathogenicrs267606578GRCh37Chr 11, 67258296: 67258297
45AIPNM_003977.2(AIP): c.807C> T (p.Phe269=)single nucleotide variantPathogenicrs139407567GRCh37Chr 11, 67258278: 67258278
46AIPNM_003977.2(AIP): c.811C> T (p.Arg271Trp)single nucleotide variantPathogenicrs267606579GRCh37Chr 11, 67258282: 67258282
47AIPNM_003977.2(AIP): c.829G> C (p.Ala277Pro)single nucleotide variantLikely pathogenicrs267606581GRCh37Chr 11, 67258300: 67258300
48AIPNM_003977.2(AIP): c.854_857delAGGC (p.Gln285Leufs)deletionLikely pathogenicrs267606582GRCh37Chr 11, 67258325: 67258328
49AIPNM_003977.2(AIP): c.919dupC (p.Gln307Profs)duplicationLikely pathogenicrs267606589GRCh37Chr 11, 67258390: 67258391
50AIPNM_003977.2(AIP): c.-220G> Asingle nucleotide variantLikely pathogenicrs267606540GRCh37Chr 11, 67250410: 67250410
51AIPNM_003977.2(AIP): c.880_891delCTGGACCCAGCC (p.Asp295_Leu298del)deletionLikely pathogenicrs267606585GRCh37Chr 11, 67258351: 67258362
52AIPNM_003977.2(AIP): c.40C> T (p.Gln14Ter)single nucleotide variantPathogenicrs104894194GRCh37Chr 11, 67250669: 67250669
53AIPNM_003977.2(AIP): c.469-1G> Asingle nucleotide variantLikely pathogenicrs267606555GRCh37Chr 11, 67257508: 67257508
54AIPNM_003977.2(AIP): c.910C> T (p.Arg304Ter)single nucleotide variantPathogenicrs104894195GRCh37Chr 11, 67258381: 67258381
55AIPNM_003977.2(AIP): c.66_71delAGGAGA (p.Gly23_Glu24del)deletionLikely pathogenicrs267606567GRCh37Chr 11, 67250695: 67250700
56AIPNM_003977.2(AIP): c.824dupA (p.His275Glnfs)duplicationLikely pathogenicrs267606580GRCh37Chr 11, 67258295: 67258296
57AIPNM_003977.2(AIP): c.542delT (p.Ile182Serfs)deletionLikely pathogenicrs267606559GRCh37Chr 11, 67257582: 67257582
58AIPNM_003977.2(AIP): c.804C> A (p.Tyr268Ter)single nucleotide variantLikely pathogenicrs121908356GRCh37Chr 11, 67258275: 67258275
59AIPNM_003977.2(AIP): c.64C> T (p.Arg22Ter)single nucleotide variantLikely pathogenicrs121908357GRCh37Chr 11, 67250693: 67250693

Expression for genes affiliated with Growth Hormone Secreting Pituitary Adenoma

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Expression patterns in normal tissues for genes affiliated with Growth Hormone Secreting Pituitary Adenoma

Search GEO for disease gene expression data for Growth Hormone Secreting Pituitary Adenoma.

Pathways for genes affiliated with Growth Hormone Secreting Pituitary Adenoma

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Pathways related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4RB1, AIP
29.4RB1, GNAS
39.3RB1, VEGFA
4
Show member pathways
9.3RB1, VEGFA
59.2GNAS, IGF1
6
Show member pathways
Development Ligand independent activation of ESR1 and ESR260
9.2GNAS, IGF1
7
Show member pathways
Arrhythmogenic right ventricular cardiomyopathy37
9.2GNAS, IGF1
89.2GNAS, IGF1
99.1IGF1, VEGFA
10
Show member pathways
9.1IGF1, VEGFA
119.1IGF1, VEGFA
12
Show member pathways
FAS pathway and Stress induction of HSP regulation37
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis37
9.0RB1, IGF1
139.0RB1, IGF1
149.0RB1, IGF1
15
Show member pathways
DNA damage response37
9.0RB1, IGF1
16
Show member pathways
8.9GNAS, PRL, RB1
17
Show member pathways
8.7GNAS, VEGFA, IGF1
18
Show member pathways
Cytoskeleton remodeling FAK signaling60
Development Endothelin 1 EDNRA transactivation of EGFR60
8.7IGF1, VEGFA, GNAS
19
Show member pathways
8.7GNAS, VEGFA, IGF1
20
Show member pathways
Transcription Receptor mediated HIF regulation60
Development CNTF receptor signaling60
Class IB PI3K non-lipid kinase events37
ErbB2/ErbB3 signaling events37
Development Growth hormone signaling via PI3K AKT and MAPK cascades60
Translation Regulation activity of EIF260
Regulation of lipid metabolism Insulin signaling generic cascades60
Transcription PPAR Pathway60
Cell adhesion PLAU signaling60
Translation Regulation activity of EIF4F60
8.7IGF1, VEGFA, GNAS
218.6IGF1, VEGFA, PRL
228.5RB1, VEGFA, IGF1
238.5RB1, VEGFA, IGF1
24
Show member pathways
Signaling Pathways in Glioblastoma37
8.5RB1, VEGFA, IGF1
25
Show member pathways
Integrin-mediated cell adhesion37
Focal Adhesion37
8.5RB1, VEGFA, IGF1
26
Show member pathways
8.2PRL, GNAS, VEGFA, IGF1

Compounds for genes affiliated with Growth Hormone Secreting Pituitary Adenoma

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Compounds related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 59)
idCompoundScoreTop Affiliating Genes
1fluoxetine44 50 28 1112.8GNAS, PRL
2quinagolide449.6PRL, IGF1
3leuprolide44 61 28 1112.6IGF1, PRL
4ghrp449.6IGF1, PRL
5pyridostigmine44 1110.6PRL, IGF1
6hexarelin44 2810.6IGF1, PRL
7leuprolide acetate449.6PRL, IGF1
8flavopiridol44 1110.6RB1, VEGFA
9lanreotide44 2810.6IGF1, PRL
10buserelin44 28 1111.5IGF1, PRL
11clomiphene citrate449.5IGF1, PRL
12naltrexone44 28 50 1112.5IGF1, PRL
13cabergoline44 28 1111.5PRL, IGF1
14estrone sulfate44 2410.5IGF1, PRL
15topotecan44 1110.5IGF1, VEGFA
16erlotinib44 50 1111.5VEGFA, IGF1
17bromocriptine44 28 1111.5PRL, IGF1
18lutein449.4IGF1, RB1
19valproate449.4IGF1, PRL
20dehydroepiandrosterone sulfate449.4IGF1, PRL
21clonidine44 50 28 1112.4IGF1, PRL
22carboplatin44 50 1111.3RB1, VEGFA
23n-(4-hydroxyphenyl)retinamide449.3RB1, IGF1
24dhea449.3IGF1, PRL
25triiodothyronine449.3IGF1, PRL
26androstenedione44 2410.2PRL, IGF1
27mifepristone44 28 61 1112.1PRL, VEGFA
28suramin44 28 1111.1IGF1, VEGFA
29acth449.1IGF1, PRL, GNAS
30gnrh449.1IGF1, PRL, GNAS
31ribonucleic acid449.1PRL, GNAS, IGF1
32progestin449.1IGF1, VEGFA, PRL
33levodopa44 1110.0IGF1, PRL
34tamoxifen44 50 28 1112.0PRL, IGF1, VEGFA
35dopamine44 28 24 1112.0PRL, GNAS, IGF1
36sb 20358044 619.9RB1, VEGFA, IGF1
37rapamycin448.9IGF1, VEGFA, RB1
38ly294002448.9VEGFA, IGF1, RB1
39actinomycin d448.9IGF1, RB1, VEGFA
40estradiol44 24 1110.9RB1, PRL, IGF1
41genistein44 28 61 2 24 1113.9IGF1, RB1, VEGFA
42thymidine44 249.8RB1, GNAS, IGF1
43testosterone44 61 24 1111.6RB1, PRL, IGF1
44octreotide44 61 28 1111.6IGF1, VEGFA, GNAS, PRL
45progesterone44 28 61 24 1112.5RB1, PRL, GNAS, IGF1
46steroid448.5RB1, IGF1, PRL, GNAS
47glucose448.5IGF1, RB1, PRL, GNAS
48dexamethasone44 50 28 1111.4RB1, IGF1, VEGFA, PRL
49estrogen448.4RB1, PRL, IGF1, VEGFA
50tyrosine448.3IGF1, VEGFA, GNAS, RB1

GO Terms for genes affiliated with Growth Hormone Secreting Pituitary Adenoma

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Cellular components related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310938.8VEGFA, IGF1
2extracellular regionGO:0055768.2PRL, GNAS, VEGFA, IGF1

Biological processes related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1lactationGO:0075959.7VEGFA, PRL
2regulation of multicellular organism growthGO:0400149.4PRL, IGF1
3positive regulation of osteoblast differentiationGO:0456699.4GNAS, IGF1
4branching morphogenesis of an epithelial tubeGO:0487549.4VEGFA, IGF1
5multicellular organism growthGO:0352649.3GNAS, IGF1
6myoblast differentiationGO:0454459.3RB1, IGF1
7positive regulation of epithelial cell proliferationGO:0506799.3IGF1, VEGFA
8female pregnancyGO:0075659.2PRL, GNAS
9positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.2VEGFA, IGF1
10Ras protein signal transductionGO:0072659.0RB1, IGF1
11platelet degranulationGO:0025769.0IGF1, VEGFA
12blood coagulationGO:0075968.9GNAS, VEGFA, IGF1
13positive regulation of transcription from RNA polymerase II promoterGO:0459448.5RB1, VEGFA, IGF1

Molecular functions related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.1PRL, IGF1
2protein bindingGO:0055156.8RB1, PRL, GNAS, VEGFA, IGF1, AIP

Products for genes affiliated with Growth Hormone Secreting Pituitary Adenoma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Growth Hormone Secreting Pituitary Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet