MCID: GRW001
MIFTS: 63

Growth Hormone Secreting Pituitary Adenoma malady

Endocrine diseases category

Summaries for Growth Hormone Secreting Pituitary Adenoma

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63Wikipedia, 46OMIM, 32MalaCards
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Wikipedia:63 Acromegaly (/ˌækrɵˈmɛɡəli/; from Ancient Greek άκρος akros \"extreme\" or \"extremities\"... more...

MalaCards: Growth Hormone Secreting Pituitary Adenoma, also known as somatotroph adenoma, is related to pituitary adenoma and adenoma. An important gene associated with Growth Hormone Secreting Pituitary Adenoma is AIP (aryl hydrocarbon receptor interacting protein), and among its related pathways are Glycoprotein hormones and Development Prolactin receptor signaling. The compounds vapreotide and dehydroepiandrosterone sulfate have been mentioned in the context of this disorder. Affiliated tissues include pituitary, endothelial and thyroid, and related mouse phenotypes are adipose tissue and endocrine/exocrine gland.

Description from OMIM:46 102200

Aliases & Classifications for Growth Hormone Secreting Pituitary Adenoma

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8Disease Ontology, 22GTR, 46OMIM, 60UMLS, 34MeSH, 56SNOMED-CT, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases


Aliases & Descriptions:

growth hormone secreting pituitary adenoma 8
somatotroph adenoma 8 22
growth hormone producing adenoma of the pituitary 8
growth hormone secreting adenoma of pituitary 8
pituitary adenoma, growth hormone-secreting 46
growth hormone-secreting pituitary adenoma 60


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Disease Ontology8 DOID:6255
MeSH34 D049912
SNOMED-CT56 254957009
NCIt39 C7461
OMIM46 102200

Related Diseases for Growth Hormone Secreting Pituitary Adenoma

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17GeneCards, 18GeneDecks
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Diseases related to Growth Hormone Secreting Pituitary Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 173)
idRelated DiseaseScoreTop Affiliating Genes
1pituitary adenoma31.7IGF1, SST, SSTR2, SSTR5, PRKAR1A, PRL
2adenoma31.7F2RL1, GNAS, CREB1, AIP, IGF1, SST
3meningioma30.7SST, SSTR2, SSTR5, MEN1
4acromegaly30.7GH1, PRL, SST, IGF1
5thyroiditis30.5CGA
6neuroendocrine tumor30.4GNAS, MEN1, GHSR, GHRL, GH1, SSTR2
7adenocarcinoma30.4CREB1, MEN1, CGB, GHR, GHRL, SSTR2
8prolactinoma30.3AIP, IGF1, SST, SSTR2, SSTR5, PRKAR1A
9amenorrhea30.1IGF1, PRL
10moyamoya disease10.3
11mixed cell adenoma10.3
12papillary carcinoma10.3
13intracranial aneurysm10.3
14aortitis10.3
15gangliocytoma10.3
16papillary adenoma10.3
17functioning pituitary adenoma10.3
18lipomatosis10.3
19papillary thyroid carcinoma10.3
20renal adenoma10.3
21renal cell carcinoma10.3
22neuronitis10.3
23pituitary hypoplasia10.0GHRHR
24goiter10.0GNAS
25pseudohypoparathyroidism10.0GNAS
26osteomalacia10.0GNAS
27irritable bowel syndrome10.0F2RL1
28hyperinsulinemic hypoglycemia10.0SST
29eating disorder10.0GHRL
30hypogonadotropism10.0PRL
31diabetes insipidus10.0PRL
32bulimia nervosa10.0GHRL
33ovarian cancer10.0CGB, SSTR2
34myocardial infarction10.0GHRL
35hepatitis10.0GHR
36hypoparathyroidism10.0PRKAR1A
37pancreatitis10.0SST, F2RL1
38duodenal neoplasm10.0SST
39lipodystrophy10.0GHR
40somatostatinoma10.0SSTR2, SST
41ileus10.0GHRL
42liver cirrhosis10.0GHR
43pancreatic islet cell tumors10.0MEN1, SST
44hypertension10.0IGF1
45dysgerminoma10.0CGA
46sarcoma10.0SSTR2, CGB
47dyspepsia10.0GHRL
48isolated growth hormone deficiency type 1b10.0GH1, GHRHR
49hyperparathyroidism10.0PRKAR1A, MEN1
50acanthosis nigricans10.0IGF1

Graphical network of the top 20 diseases related to Growth Hormone Secreting Pituitary Adenoma:



Diseases related to growth hormone secreting pituitary adenoma

Clinical Features for Growth Hormone Secreting Pituitary Adenoma

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46OMIM
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Clinical features from OMIM:

102200

Clinical synopsis from OMIM:

102200

Drugs & Therapeutics for Growth Hormone Secreting Pituitary Adenoma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Genetic Tests for Growth Hormone Secreting Pituitary Adenoma

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22GTR
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Genetic tests related to Growth Hormone Secreting Pituitary Adenoma:

id Genetic test Affiliating Genes
1 Somatotroph Adenoma22

Anatomical Context for Growth Hormone Secreting Pituitary Adenoma

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32MalaCards
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MalaCards organs/tissues related to Growth Hormone Secreting Pituitary Adenoma:

32
Pituitary, Endothelial, Thyroid, Bone, Colon, Skin

Animal Models for Growth Hormone Secreting Pituitary Adenoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Growth Hormone Secreting Pituitary Adenoma:

36 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.5GNAS, GHR, GHSR, GH1, PRKAR1A
2MP:00053799.2F2RL1, CREB1, MEN1, GHRHR, GHR, SSTR5
3MP:00053808.8MEN1, GHR, PRL, PRKAR1A, AIP, F2RL1
4MP:00020068.7MEN1, PRL, PRKAR1A, IGF1, AIP, F2RL1
5MP:00053708.6GNAS, CREM, MEN1, GHR, GH1, PRL
6MP:00053908.5GNAS, CREB1, GHRHR, GHR, GHSR, PRKAR1A
7MP:00053858.0GNAS, CREM, CREB1, MEN1, GHR, PRKAR1A
8MP:00053867.9GHRHR, CREB1, CREM, GNAS, GHR, GHSR
9MP:00053897.9CREM, CREB1, MEN1, CGA, GHRHR, GHR
10MP:00053877.9GNAS, CREB1, MEN1, GHRHR, GHR, PRL
11MP:00053787.7GNAS, CREB1, MEN1, CGA, GHRHR, GHR
12MP:00036317.4GNAS, CREM, CREB1, MEN1, CGA, GHRHR
13MP:00053766.8GHSR, GHR, GHRHR, CGA, MEN1, CREB1

Publications for Growth Hormone Secreting Pituitary Adenoma

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50PubMed
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Articles related to Growth Hormone Secreting Pituitary Adenoma:

(show top 50)    (show all 94)
idTitleAuthorsYear
1
Plurihormonal pituitary adenoma with concomitant adrenocorticotropic hormone (ACTH) and growth hormone (GH) secretion: a report of two cases and review of the literature. (24081787)
2014
2
Growth hormone secreting pituitary adenoma associated with Rathke's cleft cyst. (22824691)
2012
3
Moyamoya syndrome following growth hormone-secreting pituitary adenoma. (22592188)
2012
4
Ectopic growth hormone-secreting pituitary adenoma involving the clivus treated with octreotide: role of magnetic resonance imaging in the diagnosis and clinical follow-up. (22990736)
2012
5
Spontaneous cerebrospinal fluid rhinorrhea as the initial presentation of growth hormone-secreting pituitary adenoma. (20888068)
2011
6
MGMT immunoexpression in growth hormone-secreting pituitary adenomas and its correlation with Ki-67 labeling index and cytokeratin distribution pattern. (21792693)
2011
7
Management of coexisting thyrotropin/growth-hormone-secreting pituitary adenoma and papillary thyroid carcinoma: a therapeutic challenge. (20067380)
2010
8
Expression of Ki-67, p53 and vascular endothelial growth factor (VEGF) concomitantly in growth hormone-secreting pituitary adenomas; which one has a role in tumor behavior ? (21196926)
2010
9
Growth hormone- secreting pituitary adenomas: from molecular basis to treatment options in acromegaly. (20234189)
2010
10
Surgical results of growth hormone-secreting pituitary adenoma. (19516943)
2009
11
Expression of vascular endothelial growth factor in growth hormone-secreting pituitary adenomas: special reference to the octreotide treatment. (18953743)
2008
12
Prognostic significance of the Ki-67 labeling index in growth hormone-secreting pituitary adenomas. (18460561)
2008
13
Short-lasting, unilateral neuralgiform headache attacks with conjunctival injection and tearing syndrome treated successfully with transsphenoidal resection of a growth hormone-secreting pituitary adenoma. (18590441)
2008
14
MRI finding of simultaneous coexistence of growth hormone-secreting pituitary adenoma with intracranial meningioma and carotid artery aneurysms: report of a case. (17334927)
2007
15
A possible new syndrome with growth-hormone secreting pituitary adenoma, colonic polyposis, lipomatosis, lentigines and renal carcinoma in association with familial testicular germ cell malignancy: A case report. (17411461)
2007
16
Silent growth hormone secreting pituitary adenomas: IGF-1 is not sufficient to exclude growth hormone excess. (17270100)
2007
17
Ectopic suprasellar growth hormone-secreting pituitary adenoma: case report. (17986925)
2007
18
Expression of p53, Ki-67 and c-erb B2 in growth hormone-and/or prolactin-secreting pituitary adenomas. (16622555)
2006
19
Expression of the antiapoptotic gene seladin-1 and octreotide-induced apoptosis in growth hormone-secreting and nonfunctioning pituitary adenomas. (16091489)
2005
20
Stereotactic conformal radiotherapy in patients with growth hormone-secreting pituitary adenoma. (15234043)
2004
21
Somatostatin receptor subtype 1 selective activation in human growth hormone (GH)- and prolactin (PRL)-secreting pituitary adenomas: effects on cell viability, GH, and PRL secretion. (12788890)
2003
22
In vitro effect of human recombinant leptin and expression of leptin receptors on growth hormone-secreting human pituitary adenomas. (12354126)
2002
23
Medical management of growth hormone-secreting pituitary adenomas. (12675503)
2002
24
Prolactin (PRL)-releasing peptide stimulates PRL secretion from human fetal pituitary cultures and growth hormone release from cultured pituitary adenomas. (11397894)
2001
25
Proliferation, vascular endothelial growth factor expression and cavernous sinus invasion in growth hormone secreting pituitary adenomas. (11214627)
2000
26
Osseous metaplasia in a growth hormone-secreting pituitary adenoma. (10442463)
1999
27
Pituitary somatotroph adenoma producing growth hormone (GH)-releasing hormone (GHRH) with an elevated plasma GHRH concentration: a model case for autocrine and paracrine regulation of GH secretion by GHRH. (10487694)
1999
28
Intact leptin receptor is selectively expressed in human fetal pituitary and pituitary adenomas and signals human fetal pituitary growth hormone secretion. (9814492)
1998
29
Growth hormone-secreting pituitary adenoma associated with multiple bone cysts, skin pigmentation and aortitis syndrome. (9061509)
1996
30
Growth hormone secretion in human acromegalic pituitary adenomas: cyclic adenosine monophosphate and protein kinase C responses. (8596491)
1996
31
A case of pituitary somatotroph adenoma with concomitant secretion of growth hormone, prolactin, and adrenocorticotropic hormone--an adenoma derived from primordial stem cell, studied by immunohistochemistry, in situ hybridization, and cell culture. (8890999)
1996
32
Growth hormone secreting pituitary adenoma: Clinical aspects and surgical outcome. (17587934)
1995
33
Results of the lateral rhinotomy approach in transsphenoidal microsurgery for growth hormone-secreting pituitary adenoma. (8719832)
1995
34
Growth hormone-prolactin-thyrotropin-secreting pituitary adenoma in atypical McCune-Albright syndrome with functionally normal Gs alpha protein. (7962285)
1994
35
Presence and characterization of the somatostatin precursor in normal human pituitaries and in growth hormone secreting adenomas. (8093621)
1993
36
Differential effects of insulin-like growth factor 1 on the hormonal product and proliferation of glycoprotein-secreting human pituitary adenomas. (7691862)
1993
37
Light and electron microscopic observation of the same mammosomatotroph cell in a mixed growth hormone- and prolactin-secreting pituitary adenoma--case report. (7685856)
1993
38
Adenocarcinoma metastatic to a growth-hormone-secreting pituitary adenoma: case report. (1631761)
1992
39
Cytocidal effects of bromocriptine, somatostatin analog, and heat on growth hormone-secreting pituitary adenoma in vitro. (1571899)
1992
40
The relationship between growth hormone (GH) messenger ribonucleic acid levels and hormone release from individual cells derived from human GH-secreting pituitary adenomas. (2004472)
1991
41
Detection of growth hormone, prolactin and human beta-chorionic gonadotropin messenger RNA in growth-hormone-secreting pituitary adenomas by in situ hybridization. (2058088)
1991
42
Differential response to aminergic stimuli and biological behavior of growth hormone secreting pituitary adenomas. (2107017)
1990
43
Prolactin gene expression in human growth hormone-secreting pituitary adenomas. (2338572)
1990
44
Endocrine and immunohistochemical studies on thyrotropin (TSH)-secreting pituitary adenomas: responses of TSH, alpha-subunit, and growth hormone to hypothalamic releasing hormones and their distribution in adenoma cells. (1699960)
1990
45
Intrasellar gangliocytoma containing gastrin and growth hormone-releasing hormone associated with a growth hormone-secreting pituitary adenoma. (2512034)
1989
46
Malignant growth hormone-secreting pituitary adenoma with hematogenous dural metastasis: case report. (3047593)
1988
47
Long term treatment with the somatostatin analog SMS 201-995 in a patient with a thyrotropin- and growth hormone-secreting pituitary adenoma. (2895119)
1988
48
Results of transsphenoidal microsurgery for growth hormone-secreting pituitary adenoma in a series of 214 patients. (3373281)
1988
49
Human growth hormone-secreting pituitary adenoma cells in long-term culture: effects of dexamethasone and growth hormone releasing factor. (6421977)
1984
50
Growth hormone-secreting pituitary adenoma in uniovular twin brothers: case report. (7193813)
1981

Genetic Variations for Growth Hormone Secreting Pituitary Adenoma

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Expression for genes affiliated with Growth Hormone Secreting Pituitary Adenoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Growth Hormone Secreting Pituitary Adenoma

Search GEO for disease gene expression data for Growth Hormone Secreting Pituitary Adenoma.

Pathways for genes affiliated with Growth Hormone Secreting Pituitary Adenoma

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53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 29KEGG, 51QIAGEN
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Pathways related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

(show all 27)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.0CGA, CGB
2
Development Prolactin receptor signaling
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9.9CREB1, PRL
3
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9.8GHSR, SSTR5, SSTR2, F2RL1
4
Development A2B receptor- action via G-protein alpha s
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9.7PRKAR1A, CREB1, GNAS
59.7PRKAR1A, CREB1, GNAS
6
Development Hedgehog and PTH signaling pathways in bone and cartilage development
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9.7GNAS, CREB1, PRKAR1A
79.7GNAS, CREB1, PRKAR1A
8
Hide members
9.7PRL, GH1, GHR
9
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9.7GHRL, CGB, CGA
109.7GHSR, GHR, CGA
119.7GNAS, CREB1, CGA
129.6PRL, CGA, CREB1
139.6GHR, GH1, IGF1
149.6GNAS, CGA, IGF1
15
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9.6CREB1, GHRHR, GH1, PRKAR1A
16
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9.5CREB1, GHSR, GHRL, F2RL1
17
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9.4PRL, GH1, GHR, CREB1
18
Translation Insulin regulation of translation
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9.4IGF1, PRKAR1A, GH1, GHR
19
Development Ligand-independent activation of ESR1 and ESR2
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9.4IGF1, PRKAR1A, CREB1, GNAS
209.2SST, SSTR2, PRKAR1A, CREB1, CREM
21
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9.1IGF1, PRL, GH1, GHR, CREB1
229.1IGF1, PRL, GH1, GHR, CREB1
23
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9.0GNAS, CREM, CREB1, CGA, PRKAR1A
24
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9.0CREM, CREB1, GH1, PRKAR1A, IGF1
25
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8.8CREB1, GHR, GH1, PRL, PRKAR1A, IGF1
26
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7.8GNAS, CGA, GHRHR, GHR, GHSR, GHRL
27
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6.7F2RL1, GNAS, CREB1, MEN1, CGA, GHRHR

Compounds for genes affiliated with Growth Hormone Secreting Pituitary Adenoma

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28IUPHAR, 44Novoseek, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 151)
idCompoundScoreTop Affiliating Genes
1vapreotide28 44 1112.1SST, SSTR2, SSTR5, GHSR
2dehydroepiandrosterone sulfate4410.1CGA, GHR, GH1
3cyn 154806599.9SSTR2, SST, SSTR5
4glucose449.9CGB, GHRL, SSTR2, IGF1
5ghrp-644 2810.9GHSR, SST, GHRL
6quinagolide449.9IGF1, SST, PRL, GH1
7somatuline449.9GH1, SST, IGF1
8dexamethasone44 49 28 1112.8GHSR, GHRL, GHRHR, GH1, CREB1
9acipimox44 2810.7GH1, SST, IGF1, GHRL
10pasireotide44 1110.6SST, SSTR2, SSTR5
11pyridostigmine44 1110.6GHRL, GH1, SST, IGF1, PRL
12pirenzepine44 28 1111.6SST, IGF1, GH1, GHRL
13buserelin44 28 1111.6IGF1, SST, PRL, CGA
14clomiphene citrate449.6CGA, IGF1, CGB, GH1, PRL
15pegvisomant44 1110.5SST, GHRL, IGF1, GHR, GH1
16bromocriptine28 44 1111.5SST, CREB1, CGA, PRL, GHR
17norepinephrine44 11 2411.5GNAS, CGA, PRL, F2RL1, CREB1
18forskolin44 49 1111.5SSTR2, PRKAR1A, GHSR, CREB1, CREM, GHRHR
19leuprolide acetate449.5IGF1, CGA, GHR, GH1, PRL
20naloxone44 49 28 1112.4CGA, SST, PRL, CREB1, GHRL, GH1
21c-peptide449.4SST, GHR, GHRL, GH1, IGF1
22estradiol44 11 2411.4GHR, CGA, CREB1, CGB, PRL, GHSR
23opiate449.3F2RL1, PRL, GH1, GHRL, CGA, CREB1
24hydrocortisone44 2 59 1112.3IGF1, SST, GHSR, GHRL, PRL, GH1
25cabergoline28 44 1111.3PRL, SST, IGF1, GH1, GHR, CGA
26clonidine44 28 1111.2IGF1, SST, PRL, GH1, GHR, CGA
27androstenedione44 2410.2GH1, GHR, CGB, CGA, PRL, IGF1
28levodopa44 1110.2IGF1, SST, GH1, CREB1, GHR, PRL
29glutamate449.1PRKAR1A, GHRL, GHRHR, CGA, CREM, GNAS
30triiodothyronine449.1IGF1, PRL, GH1, GHRL, GHR, CGA
31hexarelin44 2810.0GHRHR, IGF1, SST, PRL, GH1, GHRL
32ghrp449.0GHSR, GHR, GHRHR, GHRL, GH1, PRL
33lanreotide44 289.9SSTR5, SSTR2, F2RL1, IGF1, SST, PRL
34vitamin d448.8MEN1, GHR, GHRL, PRKAR1A, IGF1, CGA
35serine448.8F2RL1, CGA, GNAS, CREM, MEN1, GH1
36thyroxine44 249.8SST, IGF1, GHRL, CGB, CGA, GH1
37dopamine44 28 11 2411.8GNAS, CREB1, GHR, F2RL1, IGF1, SSTR2
38thymidine44 249.7IGF1, SSTR2, SSTR5, GH1, GHRL, MEN1
39progesterone44 59 28 11 2412.5PRL, SSTR2, IGF1, GH1, CGA, CGB
40vegf448.5GHRL, GH1, SSTR2, SST, IGF1, F2RL1
41steroid448.4CGA, CREB1, GNAS, GHR, GHSR, GH1
42octreotide44 59 28 1111.4GNAS, GHR, GHSR, GHRL, GH1, PRL
43cyclic amp44 249.4PRKAR1A, CGB, GHRL, CREB1, GHR, GHRHR
44acth448.3GNAS, IGF1, SST, CREB1, GHR, GHSR
45ribonucleic acid448.3IGF1, SSTR2, PRL, GH1, GHRL, GHSR
46testosterone44 59 11 2411.3GHSR, GHR, CGB, GHRL, PRL, CGA
47adenylate448.3GHSR, CREB1, SST, PRKAR1A, CREM, GNAS
48gnrh448.2CGB, GHR, GHRL, GH1, PRL, SSTR2
49arginine448.0F2RL1, CGA, IGF1, SST, PRL, PRKAR1A
50tyrosine447.6F2RL1, IGF1, SSTR2, GNAS, CREM, CREB1

GO Terms for genes affiliated with Growth Hormone Secreting Pituitary Adenoma

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16Gene Ontology
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Cellular components related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1plasma membraneGO:0058868.3GHRHR, GHR, GHSR, PRKAR1A, SSTR5, SSTR2
2extracellular regionGO:0055767.9IGF1, GNAS, CGA, CGB, GHR, GHRL

Biological processes related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

(show all 35)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of appetiteGO:03210010.4GHRL, GHSR
2negative regulation of tumor necrosis factor biosynthetic processGO:04253610.4GHRL, GHSR
3negative regulation of interleukin-6 biosynthetic processGO:04540910.3GHRL, GHSR
4negative regulation of interleukin-1 beta productionGO:03269110.3GHRL, GHSR
5water homeostasisGO:03010410.3GHRHR, IGF1
6growth hormone secretionGO:03025210.3GHRL, GHSR, GHRHR
7positive regulation of growth hormone secretionGO:06012410.3GHRHR, GHRL
8Type I pneumocyte differentiationGO:06050910.2IGF1, CREB1
9growth hormone receptor signaling pathwayGO:06039610.2GHR, GH1
10response to foodGO:03209410.2GHR, GHSR
11negative regulation of organ growthGO:04662110.2MEN1, CGA
12lactationGO:00759510.1CREB1, GHRHR, PRL
13cellular response to insulin stimulusGO:03286910.1GHSR, GHR, GHRHR
14response to nutrientGO:00758410.1PRL, SSTR2, SST
15hormone-mediated signaling pathwayGO:00975510.1GHRL, GHSR, GHR
16JAK-STAT cascade involved in growth hormone signaling pathwayGO:06039710.1GHR, GH1, PRL
17adult feeding behaviorGO:00834310.1GHRL, GHSR
18positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.1F2RL1, IGF1, GH1
19actin polymerization or depolymerizationGO:00815410.0GHRL, GHSR
20positive regulation of tyrosine phosphorylation of Stat5 proteinGO:04252310.0GHR, GH1, IGF1
21response to estradiol stimulusGO:03235510.0GHR, GH1, PRL
22positive regulation of osteoblast differentiationGO:04566910.0GNAS, MEN1, IGF1
23positive regulation of insulin-like growth factor receptor signaling pathwayGO:04356810.0GHRHR, GHSR, GH1, IGF1
24regulation of insulin secretionGO:05079610.0GNAS, PRKAR1A, SSTR5
25regulation of multicellular organism growthGO:0400149.9IGF1, PRL, GHR
26positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.9GHR, GH1, IGF1
27G-protein coupled receptor signaling pathwayGO:0071869.8GHSR, GHRL, SSTR5, SST, F2RL1
28insulin-like growth factor receptor signaling pathwayGO:0480099.8IGF1, GHR
29cell-cell signalingGO:0072679.8SST, SSTR2, CGB, CGA
30negative regulation of cell proliferationGO:0082859.7IGF1, SST, SSTR2, SSTR5, MEN1
31positive regulation of JAK-STAT cascadeGO:0464279.7PRL, GH1
32positive regulation of multicellular organism growthGO:0400189.5GH1, GHRL, GHSR, GHR, GHRHR, CREB1
33response to drugGO:0424939.4GNAS, CREB1, PRL, SST
34positive regulation of transcription from RNA polymerase II promoterGO:0459449.0CREM, CREB1, MEN1, CGA, IGF1, F2RL1
35signal transductionGO:0071658.9CREM, CREB1, CGA, CGB, PRKAR1A, IGF1

Molecular functions related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1somatostatin receptor activityGO:00499410.1SSTR2, SSTR5
2prolactin receptor bindingGO:0051489.9PRL, GH1
3peptide hormone bindingGO:0170469.9GHRHR, GHR, GHSR
4growth hormone-releasing hormone receptor activityGO:0165209.8GHSR, GHRHR
5hormone activityGO:0051799.1IGF1, SST, PRL, GH1, CGB, CGA
6protein bindingGO:0055157.0GNAS, CREM, CREB1, MEN1, CGA, GHRHR

Products for genes affiliated with Growth Hormone Secreting Pituitary Adenoma

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Sources for Growth Hormone Secreting Pituitary Adenoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet