MCID: GRW001
MIFTS: 57

Growth Hormone Secreting Pituitary Adenoma malady

Cancer diseases, Endocrine diseases categories
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Summaries for Growth Hormone Secreting Pituitary Adenoma

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65Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:65 Acromegaly (/? more...

MalaCards: Growth Hormone Secreting Pituitary Adenoma, also known as somatotroph adenoma, is related to pituitary adenoma and adenoma. An important gene associated with Growth Hormone Secreting Pituitary Adenoma is AIP (aryl hydrocarbon receptor interacting protein), and among its related pathways are AHR Pathway and Chronic myeloid leukemia. The compounds flavopiridol and mifepristone have been mentioned in the context of this disorder. Affiliated tissues include pituitary, endothelial and bone, and related mouse phenotypes are liver/biliary system and limbs/digits/tail.

Description from OMIM:47 102200

Aliases & Classifications for Growth Hormone Secreting Pituitary Adenoma

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8Disease Ontology, 22GTR, 47OMIM, 62UMLS, 35MeSH, 40NCIt, 58SNOMED-CT
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Endocrine diseases


Aliases & Descriptions:

growth hormone secreting pituitary adenoma 8
somatotroph adenoma 8 22
growth hormone producing adenoma of the pituitary 8
growth hormone secreting adenoma of pituitary 8
pituitary adenoma, growth hormone-secreting 47
growth hormone-secreting pituitary adenoma 62


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Disease Ontology8 DOID:6255
MeSH35 D049912
SNOMED-CT58 254957009
NCIt40 C7461
OMIM47 102200

Related Diseases for Growth Hormone Secreting Pituitary Adenoma

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17GeneCards, 18GeneDecks
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Diseases related to Growth Hormone Secreting Pituitary Adenoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 58)
idRelated DiseaseScoreTop Affiliating Genes
1pituitary adenoma31.8AIP, IGF1, PRL, RB1
2adenoma31.8AIP, IGF1, PRL, RB1
3acromegaly30.8IGF1, PRL
4pituitary tumors30.4AIP, PRL, RB1, IGF1
5prolactinoma30.4IGF1, PRL, AIP
6amenorrhea30.3PRL, IGF1
7somatostatin analog10.6
8endotheliitis10.6
9meningioma10.5
10gangliocytoma10.4
11aortitis10.4
12moyamoya disease10.4
13adenocarcinoma10.4
14lipomatosis10.4
15neuroendocrine tumor10.4
16papillary thyroid carcinoma10.4
17thyroiditis10.4
18aneurysm10.4
19headache10.4
20neuronitis10.3
21choristoma10.2
22pituitary apoplexy10.1PRL
23craniopharyngioma10.0PRL, IGF1
24sheehan syndrome10.0PRL, IGF1
25empty sella syndrome10.0IGF1, PRL
26thyrotropin deficiency, isolated10.0PRL, IGF1
27pituitary gland disease10.0IGF1, PRL
28panhypopituitarism10.0PRL, IGF1
29anovulation10.0PRL, IGF1
30hyperprolactinemia10.0PRL, IGF1
31growth hormone deficiency10.0IGF1, PRL
32precocious puberty10.0IGF1, PRL
33hypopituitarism10.0PRL, IGF1
34hyperandrogenism10.0IGF1, PRL
35anorexia nervosa10.0PRL, IGF1
36cushing's syndrome10.0PRL, IGF1
37hypogonadism10.0IGF1, PRL
38hyperthyroidism10.0PRL, IGF1
39polycystic ovary syndrome10.0PRL, IGF1
40short stature10.0PRL, IGF1
41hypothyroidism10.0IGF1, PRL
42hypoglycemia10.0PRL, IGF1
43laryngeal squamous cell carcinoma10.0VEGFA, RB1
44retinopathy of prematurity10.0VEGFA, IGF1
45lung cancer10.0VEGFA, IGF1
46anaplastic astrocytoma10.0VEGFA, RB1
47proliferative diabetic retinopathy10.0IGF1, VEGFA
48gigantism10.0AIP, PRL, IGF1
49diabetic retinopathy10.0IGF1, VEGFA
50glioblastoma multiforme10.0VEGFA, RB1

Graphical network of the top 20 diseases related to Growth Hormone Secreting Pituitary Adenoma:



Diseases related to growth hormone secreting pituitary adenoma

Symptoms for Growth Hormone Secreting Pituitary Adenoma

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47OMIM
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Symptoms by clinical synopsis from OMIM:

102200

Clinical features from OMIM:

102200

Drugs & Therapeutics for Growth Hormone Secreting Pituitary Adenoma

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Growth Hormone Secreting Pituitary Adenoma

Search NIH Clinical Center for Growth Hormone Secreting Pituitary Adenoma

Genetic Tests for Growth Hormone Secreting Pituitary Adenoma

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22GTR
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Genetic tests related to Growth Hormone Secreting Pituitary Adenoma:

id Genetic test Affiliating Genes
1 Somatotroph Adenoma22

Anatomical Context for Growth Hormone Secreting Pituitary Adenoma

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33MalaCards
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MalaCards organs/tissues related to Growth Hormone Secreting Pituitary Adenoma:

33
Pituitary, Endothelial, Bone, Colon, Thyroid, Skin

Animal Models for Growth Hormone Secreting Pituitary Adenoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Growth Hormone Secreting Pituitary Adenoma:

37 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5RB1, PRL, VEGFA, AIP
2MP:00053718.5IGF1, VEGFA, RB1
3MP:00053858.1RB1, VEGFA, IGF1, AIP
4MP:00053898.1IGF1, VEGFA, PRL, RB1
5MP:00053788.1RB1, VEGFA, IGF1, AIP
6MP:00053877.9RB1, PRL, VEGFA, IGF1
7MP:00020067.8RB1, PRL, VEGFA, IGF1, AIP
8MP:00053797.8AIP, IGF1, VEGFA, PRL, RB1
9MP:00107717.7AIP, IGF1, VEGFA, PRL, RB1
10MP:00036317.7IGF1, VEGFA, PRL, RB1
11MP:00053767.7AIP, IGF1, VEGFA, PRL, RB1

Publications for Growth Hormone Secreting Pituitary Adenoma

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52PubMed
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Articles related to Growth Hormone Secreting Pituitary Adenoma:

(show top 50)    (show all 61)
idTitleAuthorsYear
1
Long-term changes in serum IGF-1 levels after successful surgical treatment of growth hormone-secreting pituitary adenoma. (23728452)
2013
2
Growth hormone secreting pituitary adenoma associated with Rathke's cleft cyst. (22824691)
2012
3
Neuroendocrine tumor of unknown origin metastasizing to a growth hormone-secreting pituitary adenoma. (22120409)
2012
4
Spontaneous cerebrospinal fluid rhinorrhea as the initial presentation of growth hormone-secreting pituitary adenoma. (20888068)
2011
5
Management of coexisting thyrotropin/growth-hormone-secreting pituitary adenoma and papillary thyroid carcinoma: a therapeutic challenge. (20067380)
2010
6
Analysis of differential gene expression by bead-based fiber-optic array in growth-hormone-secreting pituitary adenomas. (22993617)
2010
7
Tumor volume of growth hormone-secreting pituitary adenomas during treatment with pegvisomant: a prospective multicenter study. (19965922)
2010
8
Expression of Ki-67, p53 and vascular endothelial growth factor (VEGF) concomitantly in growth hormone-secreting pituitary adenomas; which one has a role in tumor behavior ? (21196926)
2010
9
Elevation of growth hormone secretagogue receptor type 1a mRNA expression in human growth hormone-secreting pituitary adenoma harboring G protein alpha subunit mutation. (20150876)
2010
10
Growth hormone- secreting pituitary adenomas: from molecular basis to treatment options in acromegaly. (20234189)
2010
11
Surgical results of growth hormone-secreting pituitary adenoma. (19516943)
2009
12
The role of stereotactic radiotherapy in patients with growth hormone-secreting pituitary adenoma. (18413424)
2008
13
Low levels of raf kinase inhibitory protein in growth hormone-secreting pituitary adenomas correlate with poor response to octreotide treatment. (18230656)
2008
14
Elevation of growth hormone-releasing hormone receptor messenger ribonucleic acid expression in growth hormone-secreting pituitary adenoma with Gsalpha protein mutation. (19029774)
2008
15
Expression of vascular endothelial growth factor in growth hormone-secreting pituitary adenomas: special reference to the octreotide treatment. (18953743)
2008
16
Prognostic significance of the Ki-67 labeling index in growth hormone-secreting pituitary adenomas. (18460561)
2008
17
Short-lasting, unilateral neuralgiform headache attacks with conjunctival injection and tearing syndrome treated successfully with transsphenoidal resection of a growth hormone-secreting pituitary adenoma. (18590441)
2008
18
MRI finding of simultaneous coexistence of growth hormone-secreting pituitary adenoma with intracranial meningioma and carotid artery aneurysms: report of a case. (17334927)
2007
19
A possible new syndrome with growth-hormone secreting pituitary adenoma, colonic polyposis, lipomatosis, lentigines and renal carcinoma in association with familial testicular germ cell malignancy: A case report. (17411461)
2007
20
Silent growth hormone secreting pituitary adenomas: IGF-1 is not sufficient to exclude growth hormone excess. (17270100)
2007
21
Ectopic suprasellar growth hormone-secreting pituitary adenoma: case report. (17986925)
2007
22
Effect of preoperative use of long-acting octreotide on growth hormone secreting pituitary adenoma and transsphenoidal surgery. (15844307)
2005
23
Tumor deletion mapping of chromosomal region 13q14 in 43 growth hormone secreting pituitary adenomas. (16388084)
2005
24
Stereotactic conformal radiotherapy in patients with growth hormone-secreting pituitary adenoma. (15234043)
2004
25
Sarcomatous change after sellar irradiation in a growth hormone-secreting pituitary adenoma. (14672272)
2003
26
Somatostatin analogs in treatment of non-growth hormone-secreting pituitary adenomas. (12721508)
2003
27
Growth hormone-secreting pituitary adenoma associated with primary moyamoya disease--case report. (12924597)
2003
28
Growth hormone-secreting pituitary adenoma confined to the sphenoid sinus associated with a normal-sized empty sella. (11922715)
2002
29
Expression of cyclic adenosine 3',5'-monophosphate (cAMP)-responsive element binding protein and inducible-cAMP early repressor genes in growth hormone-secreting pituitary adenomas with or without mutations of the Gsalpha gene. (11344215)
2001
30
Ectopic growth hormone-secreting pituitary adenoma in the sphenoid sinus. (11201818)
2001
31
Proliferation, vascular endothelial growth factor expression and cavernous sinus invasion in growth hormone secreting pituitary adenomas. (11214627)
2000
32
Osseous metaplasia in a growth hormone-secreting pituitary adenoma. (10442463)
1999
33
A functional thyrotropin- and growth hormone-secreting pituitary adenoma with a ultrastructurally monomorphic feature: a case study. (9700474)
1998
34
Detection of gsp oncogene in growth hormone-secreting pituitary adenomas and the study of clinical characteristics of acromegalic patients with gsp-positive pituitary tumors. (11189233)
1998
35
Growth hormone-secreting pituitary adenoma associated with multiple bone cysts, skin pigmentation and aortitis syndrome. (9061509)
1996
36
Growth hormone secreting pituitary adenoma: Clinical aspects and surgical outcome. (17587934)
1995
37
Results of the lateral rhinotomy approach in transsphenoidal microsurgery for growth hormone-secreting pituitary adenoma. (8719832)
1995
38
Hormonal and radiological effects of megavoltage radiotherapy in patients with growth hormone-secreting pituitary adenoma. (8258643)
1993
39
Detection of growth hormone, prolactin and human beta-chorionic gonadotropin mRNA in growth hormone-secreting pituitary adenomas and in prolactin-secreting pituitary adenomas by in situ hybridization using a non-isotopic detection method. (8317187)
1993
40
Coexistence of growth hormone-secreting pituitary adenoma and intracranial meningioma: a case report and review of the literature. (8282967)
1993
41
Adenocarcinoma metastatic to a growth-hormone-secreting pituitary adenoma: case report. (1631761)
1992
42
Detection of growth hormone, prolactin and human beta-chorionic gonadotropin messenger RNA in growth-hormone-secreting pituitary adenomas by in situ hybridization. (2058088)
1991
43
Differential response to aminergic stimuli and biological behavior of growth hormone secreting pituitary adenomas. (2107017)
1990
44
Prolactin gene expression in human growth hormone-secreting pituitary adenomas. (2338572)
1990
45
Intrasellar gangliocytoma containing gastrin and growth hormone-releasing hormone associated with a growth hormone-secreting pituitary adenoma. (2512034)
1989
46
Malignant growth hormone-secreting pituitary adenoma with hematogenous dural metastasis: case report. (3047593)
1988
47
Long term treatment with the somatostatin analog SMS 201-995 in a patient with a thyrotropin- and growth hormone-secreting pituitary adenoma. (2895119)
1988
48
Results of transsphenoidal microsurgery for growth hormone-secreting pituitary adenoma in a series of 214 patients. (3373281)
1988
49
Human growth hormone-secreting pituitary adenoma cells in long-term culture: effects of dexamethasone and growth hormone releasing factor. (6421977)
1984
50
Growth hormone-secreting pituitary adenoma in uniovular twin brothers: case report. (7193813)
1981

Variations for Growth Hormone Secreting Pituitary Adenoma

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Growth Hormone Secreting Pituitary Adenoma:

1 (show all 17)
id Gene Name Type Significance SNP ID Assembly Location
1GNASNM_001077488.2(GNAS): c.604C> T (p.Arg202Cys)single nucleotide variantPathogenicrs11554273GRCh37Chr 20, 57484420: 57484420
2GNASNM_001077488.2(GNAS): c.605G> A (p.Arg202His)single nucleotide variantPathogenicrs121913495GRCh37Chr 20, 57484421: 57484421
3GNASNM_001077488.2(GNAS): c.683A> G (p.Gln228Arg)single nucleotide variantPathogenicrs121913494GRCh37Chr 20, 57484596: 57484596
4GNASNM_001077488.2(GNAS): c.604C> A (p.Arg202Ser)single nucleotide variantPathogenicrs11554273GRCh37Chr 20, 57484420: 57484420
5AIPNM_003977.2(AIP): c.241C> T (p.Arg81Ter)single nucleotide variantPathogenicrs267606541GRCh37Chr 11, 67254618: 67254618
6AIPNM_003977.2(AIP): c.721A> G (p.Lys241Glu)single nucleotide variantPathogenicrs267606573GRCh37Chr 11, 67257862: 67257862
7AIPNM_003977.2(AIP): c.805_825dup21 (p.His275_Ala276insPheLysArgGlyLysAlaHis)duplicationPathogenicrs267606578GRCh37Chr 11, 67258296: 67258297
8AIPNM_003977.2(AIP): c.807C> T (p.Phe269=)single nucleotide variantPathogenicrs139407567GRCh37Chr 11, 67258278: 67258278
9AIPNM_003977.2(AIP): c.811C> T (p.Arg271Trp)single nucleotide variantPathogenicrs267606579GRCh37Chr 11, 67258282: 67258282
10AIPNM_003977.2(AIP): c.40C> T (p.Gln14Ter)single nucleotide variantPathogenicrs104894194GRCh37Chr 11, 67250669: 67250669
11AIPNM_003977.2(AIP): c.469-1G> Asingle nucleotide variantLikely pathogenic, Pathogenicrs267606555GRCh37Chr 11, 67257508: 67257508
12AIPNM_003977.2(AIP): c.910C> T (p.Arg304Ter)single nucleotide variantPathogenicrs104894195GRCh37Chr 11, 67258381: 67258381
13AIPNM_003977.2(AIP): c.66_71delAGGAGA (p.Gly23_Glu24del)deletionLikely pathogenic, Pathogenicrs267606567GRCh37Chr 11, 67250695: 67250700
14AIPNM_003977.2(AIP): c.824dupA (p.His275Glnfs)duplicationLikely pathogenic, Pathogenicrs267606580GRCh37Chr 11, 67258295: 67258296
15AIPNM_003977.2(AIP): c.542delT (p.Ile182Serfs)deletionLikely pathogenic, Pathogenicrs267606559GRCh37Chr 11, 67257582: 67257582
16AIPNM_003977.2(AIP): c.804C> A (p.Tyr268Ter)single nucleotide variantLikely pathogenic, Pathogenicrs121908356GRCh37Chr 11, 67258275: 67258275
17AIPNM_003977.2(AIP): c.64C> T (p.Arg22Ter)single nucleotide variantLikely pathogenic, Pathogenicrs121908357GRCh37Chr 11, 67250693: 67250693

Expression for genes affiliated with Growth Hormone Secreting Pituitary Adenoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Growth Hormone Secreting Pituitary Adenoma

Search GEO for disease gene expression data for Growth Hormone Secreting Pituitary Adenoma.

Pathways for genes affiliated with Growth Hormone Secreting Pituitary Adenoma

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50PathCards, 53QIAGEN, 30KEGG, 38NCBI BioSystems Database, 60Thomson Reuters, 55Reactome
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Pathways related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.4AIP, RB1
2
Show member pathways
9.3VEGFA, RB1
39.3RB1, VEGFA
49.3RB1, VEGFA
59.1VEGFA, IGF1
69.1IGF1, VEGFA
7
Show member pathways
9.1VEGFA, IGF1
89.0RB1, IGF1
99.0RB1, IGF1
109.0RB1, IGF1
11
Show member pathways
FAS pathway and Stress induction of HSP regulation38
Apoptosis and survival FAS signaling cascades60
Caspase cascade in apoptosis38
9.0RB1, IGF1
12
Show member pathways
DNA damage response38
9.0IGF1, RB1
138.6IGF1, VEGFA, PRL
14
Show member pathways
Signaling Pathways in Glioblastoma38
8.5IGF1, VEGFA, RB1
15
Show member pathways
Integrin-mediated cell adhesion38
Focal Adhesion38
8.5RB1, VEGFA, IGF1
168.5RB1, VEGFA, IGF1
178.5RB1, VEGFA, IGF1

Compounds for genes affiliated with Growth Hormone Secreting Pituitary Adenoma

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Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 51PharmGKB, 24HMDB, 3BitterDB
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Compounds related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1flavopiridol45 1110.7RB1, VEGFA
2mifepristone45 29 61 1112.6PRL, VEGFA
3carboplatin45 51 1111.6RB1, VEGFA
4quinagolide459.6IGF1, PRL
5leuprolide45 61 29 1112.6IGF1, PRL
6ghrp459.6PRL, IGF1
7hexarelin45 2910.6IGF1, PRL
8pyridostigmine45 1110.6IGF1, PRL
9lanreotide45 2910.6IGF1, PRL
10leuprolide acetate459.6IGF1, PRL
11buserelin45 29 1111.6IGF1, PRL
12clomiphene citrate459.5PRL, IGF1
13naltrexone45 29 51 1112.5PRL, IGF1
14cabergoline45 29 1111.5IGF1, PRL
15estrone sulfate45 2410.5PRL, IGF1
16topotecan45 1110.5IGF1, VEGFA
17erlotinib45 51 1111.5IGF1, VEGFA
18bromocriptine45 29 1111.5PRL, IGF1
19valproate459.5IGF1, PRL
20dehydroepiandrosterone sulfate459.5IGF1, PRL
21clonidine45 51 29 1112.5PRL, IGF1
22lutein459.4RB1, IGF1
23dhea459.4PRL, IGF1
24triiodothyronine459.4PRL, IGF1
25androstenedione45 2410.4PRL, IGF1
26thymidylate459.4RB1, VEGFA
27n-(4-hydroxyphenyl)retinamide459.4IGF1, RB1
28levodopa45 1110.4IGF1, PRL
29resveratrol45 61 24 1112.3VEGFA, RB1
30egcg459.3RB1, VEGFA
31suramin45 29 1111.3IGF1, VEGFA
32estrone45 29 24 1112.3PRL, IGF1
331,25 dihydroxy vitamin d3459.1RB1, IGF1
34octreotide45 61 29 1112.1PRL, VEGFA, IGF1
35progestin459.1PRL, VEGFA, IGF1
36hydrocortisone45 3 61 1112.0IGF1, PRL
37tamoxifen45 51 29 1112.0IGF1, VEGFA, PRL
38sb 20358045 619.9RB1, VEGFA, IGF1
39rapamycin458.9RB1, VEGFA, IGF1
40ly294002458.9RB1, VEGFA, IGF1
41actinomycin d458.9IGF1, VEGFA, RB1
42estradiol45 24 1110.9RB1, PRL, IGF1
43genistein45 29 61 3 24 1113.9IGF1, VEGFA, RB1
44progesterone45 29 61 24 1112.8IGF1, PRL, RB1
45testosterone45 61 24 1111.8RB1, PRL, IGF1
46steroid458.8IGF1, PRL, RB1
47adriamycin458.7RB1, IGF1
48vegf458.7RB1, VEGFA, IGF1
49dexamethasone45 51 29 1111.4RB1, PRL, VEGFA, IGF1
50estrogen458.4RB1, PRL, VEGFA, IGF1

GO Terms for genes affiliated with Growth Hormone Secreting Pituitary Adenoma

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16Gene Ontology
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Cellular components related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.1VEGFA, IGF1

Biological processes related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1lactationGO:0075959.5PRL, VEGFA
2regulation of multicellular organism growthGO:0400149.3PRL, IGF1
3branching morphogenesis of an epithelial tubeGO:0487549.3VEGFA, IGF1
4myoblast differentiationGO:0454459.2RB1, IGF1
5positive regulation of epithelial cell proliferationGO:0506799.2IGF1, VEGFA
6positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.1VEGFA, IGF1
7Ras protein signal transductionGO:0072658.9RB1, IGF1
8platelet degranulationGO:0025768.8IGF1, VEGFA
9positive regulation of transcription from RNA polymerase II promoterGO:0459448.5RB1, VEGFA, IGF1

Molecular functions related to Growth Hormone Secreting Pituitary Adenoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.1VEGFA, IGF1
2hormone activityGO:0051799.0PRL, IGF1
3protein bindingGO:0055157.2RB1, PRL, VEGFA, IGF1, AIP

Products for genes affiliated with Growth Hormone Secreting Pituitary Adenoma

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Sources for Growth Hormone Secreting Pituitary Adenoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet