GBS
MCID: GLL022
MIFTS: 63

Guillain-Barre Syndrome (GBS) malady

Neuronal diseases, Immune diseases, Genetic diseases categories

Summaries for Guillain-Barre Syndrome

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8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 33MedlinePlus, 3CDC, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Guillain-barre syndrome is a rare disorder that causes your immune system to attack your peripheral nervous system (pns). the pns nerves connect your brain and spinal cord with the rest of your body. damage to these nerves makes it hard for them to transmit signals. as a result, your muscles have trouble responding to your brain. no one knows what causes the syndrome. sometimes it is triggered by an infection, surgery, or a vaccination. the first symptom is usually weakness or a tingling feeling in your legs. the feeling can spread to your upper body. in severe cases, you become almost paralyzed. this is life-threatening. you might need a respirator to breathe. symptoms usually worsen over a period of weeks and then stabilize. guillain-barre can be hard to diagnose. possible tests include nerve tests and a spinal tap. most people recover. recovery can take a few weeks to a few years. treatment can help symptoms, and may include medicines or a procedure called plasma exchange. nih: national institute of neurological disorders and stroke

MalaCards: Guillain-Barre Syndrome, also known as guillain-barré syndrome, is related to influenza and herpes simplex. An important gene associated with Guillain-Barre Syndrome is HCRT (hypocretin (orexin) neuropeptide precursor), and among its related pathways are Glial Cell Differentiation and Neural Crest Differentiation. The drug immunoglobulins, intravenous and the compounds rantes and pge2 have been mentioned in the context of this disorder. Affiliated tissues include testes, spinal cord and brain, and related mouse phenotypes are muscle and cellular.

Disease Ontology:8 An autoimmune disease of peripheral nervous system that causes body's immune system to attack part of the peripheral nervous system.

Genetics Home Reference:21 Guillain-Barré syndrome is an autoimmune disorder that affects the nerves. Autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs. In Guillain-Barré syndrome, the immune response damages peripheral nerves, which are the nerves that connect the central nervous system (the brain and spinal cord) to the limbs and organs. Specifically, the immune response affects a particular part of peripheral nerves called axons, which are the extensions of nerve cells (neurons) that transmit nerve impulses. Guillain-Barré syndrome can affect the neurons that control muscle movement (motor neurons); the neurons that transmit sensory signals such as pain, temperature, and touch (sensory neurons); or both. As a result, affected individuals can experience muscle weakness or lose the ability to feel certain sensations.

NIH Rare Diseases:42 Guillain-barre syndrome is a rare disorder in which the body's immune system attacks part of the peripheral nervous system. symptoms of this disorder include muscle weakness, numbness, and tingling sensations, which can increase in intensity until the muscles cannot be used at all. usually guillain-barre syndrome occurs a few days or weeks after a person has had symptoms of a viral infection. occasionally, surgery or vaccinations will trigger the syndrome. it remains unclear why only some people develop guillain-barre syndrome. most patients recover completely, although some continue to have some degree of weakness. last updated: 11/2/2009

CDC:3 Group B Streptococcus (group B strep, GBS) is a type of bacteria that causes illness in people of all ages. It is the most common cause of some life-threatening infections in newborns, but it can be prevented.

NINDS:43 Miller Fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barr

Wikipedia:63 Guillain–Barré syndrome (GBS) (French pronunciation: more...

Description from OMIM:46 139393

Aliases & Classifications for Guillain-Barre Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 43NINDS, 48Orphanet, 56SNOMED-CT, 46OMIM, 39NCIt, 34MeSH, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Neuronal diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
guillain-barré syndrome:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

guillain-barre syndrome 8 42 21 10 44 33 60
guillain-barré syndrome 21 43 48
fisher syndrome 21 43
gbs 21 48
acute inflammatory demyelinating polyradiculoneuropathy 42
acute inflammatory demyelinating polyneuropathy 42
acute autoimmune peripheral neuropathy 42
acute immune-mediated polyneuropathy 42
acute postinfectious polyneuropathy 8
guillain-barre syndrome, familial 60
acute inflammatory polyneuropathy 21
acute infective polyneuritis nos 8
guillain-barré-strohl syndrome 48
landry-guillain-barre syndrome 21
acute infectious polyneuritis 21
acute inflammatory neuropathy 42
post-infectious polyneuritis 8
acute infective polyneuritis 8
postinfectious polyneuritis 8
acute inf. polyneuritis 8
infectious neuronitis 8


External Ids:

Disease Ontology8 DOID:12842
OMIM46 139393
NCIt39 C26790
MeSH34 D020275
ICD9CM27 357.0
MESH via Orphanet35 D020275
ICD10 via Orphanet26 G61.0
SNOMED-CT via Orphanet57 40956001
UMLS via Orphanet61 C0018378

Related Diseases for Guillain-Barre Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Guillain-Barre Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 195)
idRelated DiseaseScoreTop Affiliating Genes
1influenza30.9CR1, CCR5, CCL19
2herpes simplex30.8CR1, TNFRSF1B
3hepatitis30.7CR1, CD40LG, IL22
4miller fisher syndrome30.6SRF
5malaria30.6SRF, CR1
6neuropathy30.5PMP22, MBP, MPZ
7leukemia30.5MBP, CR1, CD40LG, IL22, SRF
8dermatitis30.4TNFRSF1B
9lupus erythematosus30.4CD40LG
10encephalitis30.4CCR5, MOG, MBP
11systemic lupus erythematosus30.4CCR5, TNFRSF1B, CR1, CD40LG, SRF
12arthritis30.3CCR5, TNFRSF1B, CR1, SRF
13rheumatoid arthritis30.3CCR5, MOG, TNFRSF1B, CR1, CD40LG, IL22
14hepatitis b30.2MOG, MBP, CR1
15pneumonia30.2TNFRSF1B, CR1, IL22
16neuritis30.2PMP2, PMP22, MBP, MPZ
17optic neuritis30.2MOG, MBP, MPZ, PLP1
18myasthenia gravis30.2CCR5, MOG, MBP, CR1, PLP1
19polyradiculoneuropathy30.2PMP22
20demyelinating polyneuropathy30.2CD1E
21chronic inflammatory demyelinating polyradiculoneuropathy30.2PMP22, CCR5, MPZ
22glomerulonephritis30.2CD40LG, CR1, CCR5
23hepatitis c30.2CCR5, MBP, CR1, CD40LG
24polyneuropathy30.2CD40LG, MPZ, MBP, TUBB, PMP22
25burkitt's lymphoma30.2TUBB, MBP, TNFRSF1B, CR1, CD40LG, SRF
26diabetes mellitus30.2PMP22, CD40LG
27diabetic neuropathy30.2PMP22, MPZ
28multiple sclerosis30.2TUBB, CCL21, CCR5, MOG, MBP, TNFRSF1B
29tuberculosis30.2SRF, CR1, TNFRSF1B, MBP
30sarcoma30.0TNFRSF1B
31tetanus29.9PLP1, CD40LG, MPZ, MBP, MOG
32chronic lymphocytic leukemia29.9CD40LG, CR1, CCR5, CCL19
33asthma29.9CCL19, CCR5, MBP, CR1, SRF
34pharyngeal-cervical-brachial variant of guillain-barré syndrome10.5
35ophthalmoplegia10.5
36hepatitis e10.4
37image syndrome10.4
38paraparetic variant of guillain-barré syndrome10.4
39pharyngitis10.4
40cervicitis10.4
41papilledema10.4
42kozlowski warren fisher syndrome10.3
43non-hodgkin lymphoma10.3
44atopic dermatitis10.3
45sarcoidosis10.3
46adult syndrome10.3
47riley-day syndrome10.3
48beriberi10.3
49hepatitis a10.3
50hairy cell leukemia10.3

Graphical network of the top 20 diseases related to Guillain-Barre Syndrome:



Diseases related to guillain-barre syndrome

Clinical Features for Guillain-Barre Syndrome

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46OMIM
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Clinical features from OMIM:

139393

Drugs & Therapeutics for Guillain-Barre Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Guillain-Barre Syndrome

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Search CenterWatch for Guillain-Barre Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Guillain-Barre Syndrome

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Anatomical Context for Guillain-Barre Syndrome

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32MalaCards
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MalaCards organs/tissues related to Guillain-Barre Syndrome:

32
Testes, Spinal cord, Brain, T cells

Animal Models for Guillain-Barre Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Guillain-Barre Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536910.0PMP22, CCR5, MOG, TNFRSF1B, HCRT, PLP1
2MP:00053849.9CCR5, MOG, MBP, TNFRSF1B, MPZ, CD40LG
3MP:00053979.9SRF, CCL19, CCR5, MOG, MBP, TNFRSF1B
4MP:00053869.8PMP22, CCR5, MOG, MBP, TNFRSF1B, MPZ
5MP:00053879.7MBP, MOG, CCR5, CCL19, TNFRSF1B, MPZ
6MP:00036319.5MBP, MOG, CCR5, PMP22, TNFRSF1B, MPZ

Publications for Guillain-Barre Syndrome

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50PubMed
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Articles related to Guillain-Barre Syndrome:

(show top 50)    (show all 138)
idTitleAuthorsYear
1
Diagnosis of Guillain-Barre syndrome and validation of Brighton criteria. (24163275)
2014
2
Guillain-Barre syndrome in Asia. (24357682)
2013
3
Guillain-Barre syndrome following spinal anaesthesia. (23763810)
2013
4
Postinfectious Guillain-Barre syndrome in a patient with methimazole-induced agranulocytosis. (24307850)
2013
5
Guillain Barre syndrome as a manifestation of neurological melioidosis. (24339608)
2013
6
An unusual case of recurrent guillain-barre syndrome of a different subtype five years after initial diagnosis. (23710387)
2013
7
Hepatitis E and Guillain-Barre syndrome. (23899686)
2013
8
Increased Guillain-Barre syndrome admissions in Shiraz, southern Iran. (24250891)
2013
9
Efficacy of low-dose intravenous cyclophosphamide in systemic lupus erythematosus presenting with Guillain-Barre syndrome-like acute axonal neuropathies: report of two cases. (23439473)
2013
10
Clinico-electrophysiological profile and predictors of functional outcome in Guillain-Barre syndrome (GBS). (24064258)
2013
11
Syringomyelia coexisting with guillain-barre syndrome. (24236267)
2013
12
Mortality in Guillain-Barre syndrome. (23576619)
2013
13
Hypertensive encephalopathy as the initial manifestation of Guillain-Barre syndrome in a 7-year-old girl. (23887224)
2013
14
Pharyngeal-cervical-brachial variant of Guillain-Barre syndrome. (23804237)
2013
15
Guillain-Barre syndrome after coronary artery bypass surgery. (22899666)
2012
16
Contamination with gangliosides in brain-derived rabies vaccine may trigger Guillain--Barre syndrome. (21949103)
2012
17
Guillain-Barre syndrome in colorectal cancer. (22524581)
2012
18
A case of acute neurogenic weakness mimicking the axonal variant of the Guillain-Barre syndrome. (23144300)
2012
19
Prevalence of bladder dysfunction, urodynamic findings, and their correlation with outcome in Guillain-Barre syndrome. (22488834)
2012
20
Recurrent Guillain-Barre syndrome following vaccination. (22267712)
2012
21
No evidence of a link between influenza vaccines and Guillain-Barre syndrome-associated antiganglioside antibodies. (21955390)
2012
22
Guillain-Barre syndrome: first description of a snake envenomation aetiology. (22172144)
2012
23
Pharyngeal-cervical-brachial variant of Guillain-Barre syndrome with predominant bulbar palsy as the initial presentation of systemic lupus erythematosus and lupus nephritis: a case report. (23253247)
2012
24
Two unusual variants of Guillain-Barre syndrome. (23162026)
2012
25
Unilateral facial palsy in Guillain-Barre syndrome (GBS): a rare occurrence. (23087283)
2012
26
TH1 and TH2 response to Campylobacter jejuni antigen in Guillain-Barre syndrome. (21482924)
2011
27
Recognizing Guillain-Barre syndrome in preschool children. (21357832)
2011
28
Keeping it simple: is there a need for the various subtyping of axonal forms of Guillain-Barre syndrome? (21551171)
2011
29
Guillain-Barre syndrome presenting with sensory disturbance following a herpes virus infection: a case report. (22136568)
2011
30
The Diagnostic, Prognostic, and differential value of enhanced MR imaging in Guillain-Barre syndrome. (21596802)
2011
31
Treatment-related fluctuation in Guillain-Barre syndrome. (21897682)
2011
32
Use of the International Classification of Functioning, Disability and Health to identify preliminary comprehensive and brief core sets for Guillain Barre syndrome. (21034203)
2011
33
Investigation of suspected Guillain-Barre syndrome in childhood: What is the role for gadolinium enhanced magnetic resonance imaging of the spine? (20626577)
2010
34
Celiac disease associated with recurrent Guillain Barre syndrome. (21048269)
2010
35
A case of diabetic neuropathy combined with Guillain-Barre syndrome. (20526398)
2010
36
Autoantibody-mediated dysfunction of sympathetic neurons in guillain-barre syndrome. (20142528)
2010
37
Factors associated with long-term functional outcomes and psychological sequelae in Guillain-Barre syndrome. (20625757)
2010
38
Guillain-Barre syndrome presenting as epiglottitis in a child. (20304295)
2010
39
Detection of anti-ganglioside antibodies in Guillain-Barre syndrome. (20876992)
2010
40
Guillain-Barre syndrome associated with peginterferon alfa-2a for chronic hepatitis C: A case report. (21160989)
2010
41
Dry beriberi mimicking the Guillain-Barre syndrome. (19608771)
2009
42
Hairy cell leukemia presenting with Guillain-Barre syndrome. (17487755)
2007
43
Focal segmental glomerulosclerosis and Guillain-Barre syndrome associated with Campylobacter enteritis. (17894770)
2007
44
T cell reactivity to P0, P2, PMP-22, and myelin basic protein in patients with Guillain-Barre syndrome and chronic inflammatory demyelinating polyradiculoneuropathy. (16170091)
2005
45
Circulating tumour necrosis factor alpha & soluble TNF receptors in patients with Guillain-Barre syndrome. (14609050)
2003
46
Guillain-Barre syndrome in patient with Burkitt's lymphoma and type 2 diabetes mellitus. (11928901)
2001
47
Dysautonomia in Guillain Barre syndrome. (3654548)
1987
48
Laseque's sign--an important bedside diagnostic sign in acute polyradiculopathy (Guillain-Barre syndrome). (451640)
1979
49
CSF immunoglobulins and viral antibodies in acute transverse myelitis and Guillain-Barre syndrome. (745669)
1978
50
Mechanism of production of papilledema in the Guillain-Barre syndrome. (13493684)
1958

Genetic Variations for Guillain-Barre Syndrome

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Expression for genes affiliated with Guillain-Barre Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Guillain-Barre Syndrome

Search GEO for disease gene expression data for Guillain-Barre Syndrome.

Pathways for genes affiliated with Guillain-Barre Syndrome

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37NCBI BioSystems Database, 53Reactome, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Guillain-Barre Syndrome

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44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Guillain-Barre Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1rantes4410.8CD40LG
2pge24410.8CCL19
3cardiolipin44 1111.8MPZ
4cerebrosides4410.7MBP, MPZ
5endotoxin4410.7SRF, TNFRSF1B
6sulfatide4410.7MBP, MPZ, PLP1
72,3-cyclic nucleotide4410.7PLP1, MPZ, MBP, MOG
8mip-3beta4410.7CCL19, CCL21
9glatiramer acetate44 1111.7MOG, MBP, MPZ, PLP1
10larc4410.6CCR5, CCL21, CCL19
11c3bot (154-182)5910.6MOG, MBP
12ivig4410.6CCR5, MBP, TNFRSF1B, CD40LG
13ono 25065910.6MOG, MBP
14nogo-66 (1-40)5910.6MOG, MBP
15mog (35-55)5910.6MOG, MBP
16plp (139-151)5910.6MOG, MBP
17cocaine44 1111.6CCR5, MBP, HCRT, CD40LG, PLP1
18ganglioside4410.6PMP22, MBP, MPZ, CD40LG, SRF
19gaba4410.6PMP22, TUBB, MBP, HCRT, PLP1
20tarc4410.6CCR5, CCL21, CCL19
21ccl344 2811.5CCL19, CCL21, CCR5
22methionine4410.5TUBB, CCR5, TNFRSF1B, CR1, MPZ, PLP1
23formaldehyde44 2411.5TUBB, MBP, CR1, CD40LG
24norepinephrine44 11 2412.5MBP, TNFRSF1B, HCRT, CD40LG, SRF
25acetylcholine44 49 28 11 2414.5MOG, MBP, HCRT, CD40LG, PLP1, SRF
26cyclosporin a44 28 5912.5CCR5, MBP, TNFRSF1B, CR1, CD40LG, SRF
27cholesterol44 28 11 2413.5CCR5, TNFRSF1B, MPZ, HCRT, PLP1, SRF
28adenylate4410.5TUBB, MBP, TNFRSF1B, CR1, HCRT, CD40LG
29forskolin44 49 1112.5PMP22, TUBB, MBP, TNFRSF1B, SRF
30aspartate4410.4CD40LG, MPZ, CCR5, PMP22
31serine4410.4PMP22, TUBB, CCR5, MOG, TNFRSF1B, MPZ
32neopterin4410.4SRF, CD40LG, TNFRSF1B
33nitric oxide44 11 2412.4TUBB, MOG, TNFRSF1B, CR1, HCRT, SRF
34arginine4410.4PMP22, CCR5, MBP, TNFRSF1B, MPZ, CD40LG
35cysteine4410.4PMP22, TUBB, CCR5, MBP, TNFRSF1B, MPZ
36glutamate4410.4TUBB, CCR5, MBP, MPZ, HCRT, CD40LG
37estrogen4410.4TUBB, CCR5, MBP, TNFRSF1B, HCRT, CD40LG
38heparin44 28 11 2413.4CCR5, CR1, CD40LG, SRF
39retinoic acid44 2411.4PMP22, CCR5, MBP, TNFRSF1B, CR1, CD40LG
40creatinine4410.3TUBB, MBP, MPZ, CD40LG, SRF
41cyclic amp44 2411.3TNFRSF1B, HCRT, PLP1, SRF
42alanine4410.3TUBB, CCR5, MBP, HCRT, CD40LG, SRF
43silver4410.3PLP1, MBP, MOG
44polyethylene glycol4410.3CD40LG, TNFRSF1B, MBP
45oxygen44 2411.3MOG, TNFRSF1B, CR1, IL22
46tyrosine4410.2TUBB, CCR5, MBP, TNFRSF1B, CR1, MPZ
47lipid4410.2PMP2, TUBB, MOG, MBP, TNFRSF1B, MPZ
48galactosylceramide4410.2MBP, CCR5
49calcium44 49 11 2413.1TUBB, CCL19, CCL21, CCR5, MOG, TNFRSF1B
50polysaccharide449.9CCR5, GALE, CR1, CD40LG

GO Terms for genes affiliated with Guillain-Barre Syndrome

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16Gene Ontology
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Cellular components related to Guillain-Barre Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1myelin sheathGO:04320910.4PLP1, MPZ
2compact myelinGO:04321810.2MBP, PMP22
3plasma membraneGO:0058869.5PMP22, TUBB, CCR5, MOG, MBP, TNFRSF1B

Biological processes related to Guillain-Barre Syndrome according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of glycoprotein biosynthetic processGO:01056010.6CCL21, CCL19
2immunological synapse formationGO:00177110.5CCL21, CCL19
3dendritic cell chemotaxisGO:00240710.5CCL19, CCL21, CCR5
4negative regulation of leukocyte apoptotic processGO:200010710.5CCL19, CCL21
5axon ensheathmentGO:00836610.5PLP1, MBP
6cell maturationGO:04846910.5CCL19, CCL21, PLP1
7establishment of T cell polarityGO:00176810.5CCL19, CCL21
8response to prostaglandin E stimulusGO:03469510.4CCL21, CCL19
9positive regulation of dendritic cell antigen processing and presentationGO:00260610.4CCL19, CCL21
10synaptic transmissionGO:00726810.4PMP22, MBP, MPZ, HCRT, PLP1
11positive regulation of cell motilityGO:200014710.4CCL19, CCL21
12inflammatory responseGO:00695410.3IL22, CD40LG, TNFRSF1B, CCR5, CCL21, CCL19
13membrane organizationGO:06102410.3PMP2, MBP
14immune responseGO:00695510.3CCL19, CCL21, CCR5, MBP, TNFRSF1B, CD1E
15positive regulation of neutrophil chemotaxisGO:09002310.3CCL21, CCL19
16positive regulation of chemotaxisGO:05092110.2CCL19, CCL21
17positive regulation of receptor-mediated endocytosisGO:04826010.0CCL21, CCL19

Molecular functions related to Guillain-Barre Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of myelin sheathGO:01991110.3PLP1, MBP
2CCR7 chemokine receptor bindingGO:03173210.0CCL21, CCL19

Products for genes affiliated with Guillain-Barre Syndrome

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Sources for Guillain-Barre Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet