GBS
MCID: GLL022
MIFTS: 63

Guillain-Barre Syndrome (GBS) malady

Neuronal diseases, Immune diseases, Genetic diseases categories

Summaries for Guillain-Barre Syndrome

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8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 33MedlinePlus, 3CDC, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Guillain-barre syndrome is a rare disorder that causes your immune system to attack your peripheral nervous system (pns). the pns nerves connect your brain and spinal cord with the rest of your body. damage to these nerves makes it hard for them to transmit signals. as a result, your muscles have trouble responding to your brain. no one knows what causes the syndrome. sometimes it is triggered by an infection, surgery, or a vaccination. the first symptom is usually weakness or a tingling feeling in your legs. the feeling can spread to your upper body. in severe cases, you become almost paralyzed. this is life-threatening. you might need a respirator to breathe. symptoms usually worsen over a period of weeks and then stabilize. guillain-barre can be hard to diagnose. possible tests include nerve tests and a spinal tap. most people recover. recovery can take a few weeks to a few years. treatment can help symptoms, and may include medicines or a procedure called plasma exchange. nih: national institute of neurological disorders and stroke

MalaCards: Guillain-Barre Syndrome, also known as guillain-barré syndrome, is related to influenza and herpes simplex. An important gene associated with Guillain-Barre Syndrome is HCRT (hypocretin (orexin) neuropeptide precursor), and among its related pathways are Glial Cell Differentiation and Neural Crest Differentiation. The drug immunoglobulins, intravenous and the compounds rantes and pge2 have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes, and related mouse phenotypes are muscle and cellular.

Disease Ontology:8 An autoimmune disease of peripheral nervous system that causes body's immune system to attack part of the peripheral nervous system.

Genetics Home Reference:21 Guillain-Barré syndrome is an autoimmune disorder that affects the nerves. Autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs. In Guillain-Barré syndrome, the immune response damages peripheral nerves, which are the nerves that connect the central nervous system (the brain and spinal cord) to the limbs and organs. Specifically, the immune response affects a particular part of peripheral nerves called axons, which are the extensions of nerve cells (neurons) that transmit nerve impulses. Guillain-Barré syndrome can affect the neurons that control muscle movement (motor neurons); the neurons that transmit sensory signals such as pain, temperature, and touch (sensory neurons); or both. As a result, affected individuals can experience muscle weakness or lose the ability to feel certain sensations.

NIH Rare Diseases:42 Guillain-barre syndrome is a rare disorder in which the body's immune system attacks part of the peripheral nervous system. symptoms of this disorder include muscle weakness, numbness, and tingling sensations, which can increase in intensity until the muscles cannot be used at all. usually guillain-barre syndrome occurs a few days or weeks after a person has had symptoms of a viral infection. occasionally, surgery or vaccinations will trigger the syndrome. it remains unclear why only some people develop guillain-barre syndrome. most patients recover completely, although some continue to have some degree of weakness. last updated: 11/2/2009

CDC:3 Group B Streptococcus (group B strep, GBS) is a type of bacteria that causes illness in people of all ages. It is the most common cause of some life-threatening infections in newborns, but it can be prevented.

NINDS:43 Miller Fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barr

Wikipedia:63 Guillain–Barré syndrome (GBS) (French pronunciation: more...

Description from OMIM:46 139393

Aliases & Classifications for Guillain-Barre Syndrome

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8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 43NINDS, 48Orphanet, 56SNOMED-CT, 46OMIM, 39NCIt, 34MeSH, 27ICD9CM, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases
Anatomical: Neuronal diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

48
guillain-barré syndrome:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

guillain-barre syndrome 8 42 21 10 44 33 60
guillain-barré syndrome 21 43 48
fisher syndrome 21 43
gbs 21 48
acute inflammatory demyelinating polyradiculoneuropathy 42
acute inflammatory demyelinating polyneuropathy 42
acute autoimmune peripheral neuropathy 42
acute immune-mediated polyneuropathy 42
acute postinfectious polyneuropathy 8
guillain-barre syndrome, familial 60
acute inflammatory polyneuropathy 21
acute infective polyneuritis nos 8
guillain-barré-strohl syndrome 48
landry-guillain-barre syndrome 21
acute infectious polyneuritis 21
acute inflammatory neuropathy 42
post-infectious polyneuritis 8
acute infective polyneuritis 8
postinfectious polyneuritis 8
acute inf. polyneuritis 8
infectious neuronitis 8


External Ids:

Disease Ontology8 DOID:12842
OMIM46 139393
NCIt39 C26790
MeSH34 D020275
ICD9CM27 357.0
MESH via Orphanet35 D020275
ICD10 via Orphanet26 G61.0
SNOMED-CT via Orphanet57 40956001
UMLS via Orphanet61 C0018378

Related Diseases for Guillain-Barre Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Guillain-Barre Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 195)
idRelated DiseaseScoreTop Affiliating Genes
1influenza30.9CR1, CCR5, CCL19
2herpes simplex30.8CR1, TNFRSF1B
3hepatitis30.7CR1, CD40LG, IL22
4miller fisher syndrome30.6SRF
5malaria30.6SRF, CR1
6neuropathy30.5PMP22, MBP, MPZ
7leukemia30.5MBP, CR1, CD40LG, IL22, SRF
8dermatitis30.4TNFRSF1B
9lupus erythematosus30.4CD40LG
10encephalitis30.4CCR5, MOG, MBP
11systemic lupus erythematosus30.4CCR5, TNFRSF1B, CR1, CD40LG, SRF
12arthritis30.3CCR5, TNFRSF1B, CR1, SRF
13rheumatoid arthritis30.3CCR5, MOG, TNFRSF1B, CR1, CD40LG, IL22
14hepatitis b30.2MOG, MBP, CR1
15pneumonia30.2TNFRSF1B, CR1, IL22
16neuritis30.2PMP2, PMP22, MBP, MPZ
17optic neuritis30.2MOG, MBP, MPZ, PLP1
18myasthenia gravis30.2CCR5, MOG, MBP, CR1, PLP1
19polyradiculoneuropathy30.2PMP22
20demyelinating polyneuropathy30.2CD1E
21chronic inflammatory demyelinating polyradiculoneuropathy30.2PMP22, CCR5, MPZ
22glomerulonephritis30.2CD40LG, CR1, CCR5
23hepatitis c30.2CCR5, MBP, CR1, CD40LG
24polyneuropathy30.2CD40LG, MPZ, MBP, TUBB, PMP22
25burkitt's lymphoma30.2TUBB, MBP, TNFRSF1B, CR1, CD40LG, SRF
26diabetes mellitus30.2PMP22, CD40LG
27diabetic neuropathy30.2PMP22, MPZ
28multiple sclerosis30.2TUBB, CCL21, CCR5, MOG, MBP, TNFRSF1B
29tuberculosis30.2SRF, CR1, TNFRSF1B, MBP
30sarcoma30.0TNFRSF1B
31tetanus29.9PLP1, CD40LG, MPZ, MBP, MOG
32chronic lymphocytic leukemia29.9CD40LG, CR1, CCR5, CCL19
33asthma29.9CCL19, CCR5, MBP, CR1, SRF
34pharyngeal-cervical-brachial variant of guillain-barré syndrome10.5
35ophthalmoplegia10.5
36hepatitis e10.4
37image syndrome10.4
38paraparetic variant of guillain-barré syndrome10.4
39pharyngitis10.4
40cervicitis10.4
41papilledema10.4
42kozlowski warren fisher syndrome10.3
43non-hodgkin lymphoma10.3
44atopic dermatitis10.3
45sarcoidosis10.3
46adult syndrome10.3
47riley-day syndrome10.3
48beriberi10.3
49hepatitis a10.3
50hairy cell leukemia10.3

Graphical network of the top 20 diseases related to Guillain-Barre Syndrome:



Diseases related to guillain-barre syndrome

Clinical Features for Guillain-Barre Syndrome

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46OMIM
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Clinical features from OMIM:

139393

Drugs & Therapeutics for Guillain-Barre Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Guillain-Barre Syndrome

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Search CenterWatch for Guillain-Barre Syndrome

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Guillain-Barre Syndrome

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Anatomical Context for Guillain-Barre Syndrome

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32MalaCards
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MalaCards organs/tissues related to Guillain-Barre Syndrome:

32
Brain, Spinal cord, Testes, T cells

Animal Models for Guillain-Barre Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Guillain-Barre Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000536910.0PMP22, CCR5, MOG, TNFRSF1B, HCRT, PLP1
2MP:00053849.9CCR5, MOG, MBP, TNFRSF1B, MPZ, CD40LG
3MP:00053979.9SRF, CCL19, CCR5, MOG, MBP, TNFRSF1B
4MP:00053869.8PMP22, CCR5, MOG, MBP, TNFRSF1B, MPZ
5MP:00053879.7MBP, MOG, CCR5, CCL19, TNFRSF1B, MPZ
6MP:00036319.5MBP, MOG, CCR5, PMP22, TNFRSF1B, MPZ

Publications for Guillain-Barre Syndrome

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50PubMed
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Articles related to Guillain-Barre Syndrome:

(show top 50)    (show all 138)
idTitleAuthorsYear
1
Guillain-Barre syndrome associated with preceding hepatitis E virus infection. (24415572)
2014
2
Guillain-Barre Syndrome, Influenza and Influenza Vaccination--the Epidemiologic Evidence. (24415636)
2014
3
An unusual case of Guillain-Barre syndrome following toxic shock syndrome in a burned child. (24182693)
2013
4
Guillain-Barre syndrome following quadrivalent human papillomavirus vaccination among vaccine-eligible individuals in the United States. (24013368)
2013
5
Guillain-Barre syndrome-like illness in association with electrical shock injury. (24136915)
2013
6
Simple bedside predictors of mechanical ventilation in patients with Guillain-Barre syndrome. (24378177)
2013
7
Acute hepatitis E complicated by Guillain-Barre syndrome in Portugal, December 2012--a case report. (23987830)
2013
8
A multicentre prospective study of Guillain-Barre Syndrome in Japan: a focus on the incidence of subtypes. (24273220)
2013
9
The role of cytomegalovirus, Haemophilus influenzae and Epstein Barr virus in Guillain Barre syndrome. (23852841)
2013
10
Guillain-Barre syndrome in an adult patient with Henoch-Schonlein purpura. (23559644)
2013
11
Weakness and the inability to ambulate in a 14-month-old female: a case report and concise review of guillain-barre syndrome. (23431480)
2013
12
A rare case of infectious mononucleosis complicated by guillain-barre syndrome. (23888210)
2013
13
Guillain-Barre syndrome with acute lymphoblastic leukemia. (24036643)
2013
14
Prevalence and profile of sleep disturbances in Guillain-Barre Syndrome: a prospective questionnaire-based study during 10 days of hospitalization. (22642612)
2013
15
Multiple cranial neuropathies without limb involvements: guillain-barre syndrome variant? (24236266)
2013
16
Outcome and its predictors in Guillain-Barre syndrome. (22566597)
2012
17
Heterotopic ossification of the hips in a patient with Guillain Barre syndrome demonstrated on SPECT/CT. (22899193)
2012
18
A report of a probable case of familial Guillain Barre syndrome. (23349598)
2012
19
Relevance of anxiety in clinical practice of Guillain-Barre syndrome: a cohort study. (22923622)
2012
20
Risk of confirmed Guillain-Barre syndrome following receipt of monovalent inactivated influenza A (H1N1) and seasonal influenza vaccines in the Vaccine Safety Datalink Project, 2009-2010. (22582210)
2012
21
Guillain-Barre syndrome associated with Norovirus infection. (22736780)
2012
22
Froin's syndrome: an uncommon mimicker of Guillain-Barre syndrome. (22447409)
2012
23
High incidence of Guillain-Barre syndrome in children, Bangladesh. (21762603)
2011
24
Involvement of sensory fibres in axonal subtypes of Guillain-Barre syndrome. (21444320)
2011
25
Thickening and contrast enhancement of spinal roots on MR imaging in Guillain-Barre syndrome: thoughts on pathologic background. (21903912)
2011
26
Early recognition of poor prognosis in Guillain-Barre syndrome. (21403108)
2011
27
Guillain-Barre syndrome in children. (21427674)
2011
28
Anti-glycolipid GM2-positive Guillain-Barre syndrome due to hepatitis E infection. (21063804)
2011
29
Guillain Barre syndrome in a family: a case report of four siblings. (21419029)
2011
30
Guillain-Barre syndrome and adjuvanted pandemic influenza A (H1N1) 2009 vaccine: multinational case-control study in Europe. (21750072)
2011
31
Neurofascin as target of autoantibodies in Guillain-Barre syndrome. (21278083)
2011
32
Guillain-barre syndrome following spinal fusion for thoracic vertebral fracture. (22259696)
2011
33
Guillain-Barre syndrome: a clinical study in King Chulalongkorn Memorial Hospital. (20973317)
2010
34
Guillain-Barre syndrome: management and treatment options for patients with moderate to severe progression. (20968225)
2010
35
Guillain-Barre syndrome after influenza vaccine administration: two adult cases. (20939203)
2010
36
Comparison of immunoblotting and ELISA for detection of anti-ganglioside antibodies in children with Guillain-Barre syndrome. (20574125)
2010
37
The "Child in the Barrel syndrome"--severe pharyngeal-cervical-brachial variant of Guillain-Barre Syndrome in a toddler. (19569002)
2008
38
AMSAN variant of Guillain Barre syndrome progressing to chronic inflammatory demyelinating polyneuropathy in a patient with Marfan's syndrome and pulmonary tuberculosis. (16515122)
2005
39
Fas polymorphisms are associated with the presence of anti-ganglioside antibodies in Guillain-Barre syndrome. (15748958)
2005
40
Guillain-Barre syndrome with meningoencephalitis after Campylobacter jejuni infection. (15602203)
2004
41
Serum tumour necrosis factor-alpha and soluble tumour necrosis factor receptors levels in patients with Guillain-Barre syndrome. (14653854)
2004
42
Bickerstaff's brainstem encephalitis, Miller Fisher syndrome and Guillain-Barre syndrome overlap with negative anti-GQ1b antibodies. (12603297)
2003
43
Detection of galE gene by polymerase chain reaction in campylobacters associated with Guillain-Barre syndrome. (14602483)
2003
44
Visual loss with papilledema in Guillain-Barre syndrome. (12577118)
2002
45
Severe cardiovascular autonomic dysfunction in a patient with Guillain-Barre syndrome: a case report. (11269930)
2000
46
HLA alleles in patients with Guillain-Barre syndrome. (11776098)
2000
47
Guillain-Barre syndrome following 2-chlorodeoxyadenosine treatment for Hairy Cell Leukemia. (11342351)
2000
48
A neurophysiological study in children with Miller Fisher syndrome and Guillain-Barre syndrome. (9134191)
1997
49
Overlap of Guillain-Barre syndrome and Bickerstaff's brainstem encephalitis. (9073040)
1997
50
Membranous glomerulonephritis and Landry-Guillain-Barre syndrome. (3766533)
1986

Genetic Variations for Guillain-Barre Syndrome

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Expression for genes affiliated with Guillain-Barre Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Guillain-Barre Syndrome

Search GEO for disease gene expression data for Guillain-Barre Syndrome.

Pathways for genes affiliated with Guillain-Barre Syndrome

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37NCBI BioSystems Database, 53Reactome, 29KEGG, 51QIAGEN
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Compounds for genes affiliated with Guillain-Barre Syndrome

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44Novoseek, 11DrugBank, 59Tocris Bioscience, 28IUPHAR, 24HMDB, 49PharmGKB
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Compounds related to Guillain-Barre Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1rantes4410.8CD40LG
2pge24410.8CCL19
3cardiolipin44 1111.8MPZ
4cerebrosides4410.7MPZ, MBP
5endotoxin4410.7SRF, TNFRSF1B
6sulfatide4410.7PLP1, MBP, MPZ
72,3-cyclic nucleotide4410.7MOG, MBP, MPZ, PLP1
8glatiramer acetate44 1111.7MBP, MOG, PLP1, MPZ
9mip-3beta4410.7CCL21, CCL19
10larc4410.6CCL21, CCL19, CCR5
11plp (139-151)5910.6MOG, MBP
12ivig4410.6CCR5, MBP, CD40LG, TNFRSF1B
13c3bot (154-182)5910.6MBP, MOG
14ono 25065910.6MOG, MBP
15nogo-66 (1-40)5910.6MOG, MBP
16mog (35-55)5910.6MOG, MBP
17cocaine44 1111.6PLP1, CD40LG, HCRT, MBP, CCR5
18ganglioside4410.6SRF, CD40LG, MPZ, PMP22, MBP
19gaba4410.6PLP1, HCRT, MBP, TUBB, PMP22
20tarc4410.6CCL19, CCR5, CCL21
21ccl344 2811.5CCL19, CCL21, CCR5
22methionine4410.5PLP1, TNFRSF1B, CR1, CCR5, MPZ, TUBB
23formaldehyde44 2411.5CD40LG, TUBB, MBP, CR1
24norepinephrine44 11 2412.5CD40LG, MBP, TNFRSF1B, HCRT, SRF
25acetylcholine44 49 28 11 2414.5MBP, HCRT, CD40LG, PLP1, SRF, MOG
26cyclosporin a44 28 5912.5SRF, CD40LG, CR1, MBP, CCR5, TNFRSF1B
27cholesterol44 28 11 2413.5CCR5, TNFRSF1B, HCRT, PLP1, SRF, MPZ
28adenylate4410.5CD40LG, HCRT, TUBB, TNFRSF1B, CR1, MBP
29forskolin44 49 1112.5SRF, TUBB, TNFRSF1B, MBP, PMP22
30aspartate4410.4MPZ, CCR5, PMP22, CD40LG
31serine4410.4TNFRSF1B, PMP22, CCR5, SRF, MPZ, TUBB
32neopterin4410.4TNFRSF1B, SRF, CD40LG
33nitric oxide44 11 2412.4SRF, HCRT, TUBB, TNFRSF1B, MOG, CR1
34arginine4410.4TNFRSF1B, CD40LG, SRF, PLP1, MPZ, CCR5
35cysteine4410.4TUBB, PMP22, MBP, TNFRSF1B, MPZ, CD40LG
36glutamate4410.4TUBB, PLP1, CD40LG, HCRT, MBP, SRF
37estrogen4410.4HCRT, CCR5, MBP, TNFRSF1B, CD40LG, SRF
38heparin44 28 11 2413.4CR1, CCR5, SRF, CD40LG
39retinoic acid44 2411.4SRF, CCR5, PMP22, CR1, PLP1, CD40LG
40creatinine4410.3CD40LG, MPZ, MBP, TUBB, SRF
41cyclic amp44 2411.3HCRT, SRF, PLP1, TNFRSF1B
42alanine4410.3CD40LG, HCRT, SRF, MBP, CCR5, TUBB
43silver4410.3MOG, MBP, PLP1
44polyethylene glycol4410.3TNFRSF1B, MBP, CD40LG
45oxygen44 2411.3MOG, TNFRSF1B, CR1, IL22
46tyrosine4410.2CCR5, MBP, TUBB, MPZ, HCRT, INPP5J
47lipid4410.2MBP, TNFRSF1B, TUBB, PMP2, MPZ, INPP5J
48galactosylceramide4410.2CCR5, MBP
49calcium44 49 11 2413.1TUBB, CR1, TNFRSF1B, INPP5J, PLP1, SRF
50polysaccharide449.9CR1, CD40LG, CCR5, GALE

GO Terms for genes affiliated with Guillain-Barre Syndrome

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16Gene Ontology
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Cellular components related to Guillain-Barre Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1myelin sheathGO:04320910.4PLP1, MPZ
2compact myelinGO:04321810.2MBP, PMP22
3plasma membraneGO:0058869.5PMP22, TUBB, CCR5, MOG, MBP, TNFRSF1B

Biological processes related to Guillain-Barre Syndrome according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of glycoprotein biosynthetic processGO:01056010.6CCL21, CCL19
2immunological synapse formationGO:00177110.5CCL21, CCL19
3dendritic cell chemotaxisGO:00240710.5CCL19, CCL21, CCR5
4negative regulation of leukocyte apoptotic processGO:200010710.5CCL19, CCL21
5axon ensheathmentGO:00836610.5PLP1, MBP
6cell maturationGO:04846910.5CCL19, CCL21, PLP1
7establishment of T cell polarityGO:00176810.5CCL19, CCL21
8response to prostaglandin E stimulusGO:03469510.4CCL21, CCL19
9positive regulation of dendritic cell antigen processing and presentationGO:00260610.4CCL19, CCL21
10synaptic transmissionGO:00726810.4PMP22, MBP, MPZ, HCRT, PLP1
11positive regulation of cell motilityGO:200014710.4CCL19, CCL21
12inflammatory responseGO:00695410.3IL22, CD40LG, TNFRSF1B, CCR5, CCL21, CCL19
13membrane organizationGO:06102410.3PMP2, MBP
14immune responseGO:00695510.3CCL19, CCL21, CCR5, MBP, TNFRSF1B, CD1E
15positive regulation of neutrophil chemotaxisGO:09002310.3CCL21, CCL19
16positive regulation of chemotaxisGO:05092110.2CCL19, CCL21
17positive regulation of receptor-mediated endocytosisGO:04826010.0CCL21, CCL19

Molecular functions related to Guillain-Barre Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of myelin sheathGO:01991110.3PLP1, MBP
2CCR7 chemokine receptor bindingGO:03173210.0CCL21, CCL19

Products for genes affiliated with Guillain-Barre Syndrome

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Sources for Guillain-Barre Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet