GBS
MCID: GLL022
MIFTS: 54

Guillain-Barre Syndrome (GBS) malady

Neuronal category

Summaries for Guillain-Barre Syndrome

Sources:
8Disease Ontology, 21Genetics Home Reference, 43NIH Rare Diseases, 34MedlinePlus, 44NINDS, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Guillain-barre syndrome is a rare disorder that causes your immune system to attack your peripheral nervous system (pns). the pns nerves connect your brain and spinal cord with the rest of your body. damage to these nerves makes it hard for them to transmit signals. as a result, your muscles have trouble responding to your brain. no one knows what causes the syndrome. sometimes it is triggered by an infection, surgery, or a vaccination. the first symptom is usually weakness or a tingling feeling in your legs. the feeling can spread to your upper body. in severe cases, you become almost paralyzed. this is life-threatening. you might need a respirator to breathe. symptoms usually worsen over a period of weeks and then stabilize. guillain-barre can be hard to diagnose. possible tests include nerve tests and a spinal tap. most people recover. recovery can take a few weeks to a few years. treatment can help symptoms, and may include medicines or a procedure called plasma exchange. nih: national institute of neurological disorders and stroke

MalaCards: Guillain-Barre Syndrome, also known as guillain-barré syndrome, is related to hepatitis b and miller fisher syndrome. An important gene associated with Guillain-Barre Syndrome is HCRT (hypocretin (orexin) neuropeptide precursor), and among its related pathways are Glial Cell Differentiation and Neural Crest Differentiation. The drug immunoglobulins, intravenous and the compounds rantes and pge2 have been mentioned in the context of this disorder. Related mouse phenotypes are muscle and cellular.

Disease Ontology:8 An autoimmune disease of peripheral nervous system that causes body's immune system to attack part of the peripheral nervous system.

Genetics Home Reference:21 Guillain-Barré syndrome is an autoimmune disorder that affects the nerves. Autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs. In Guillain-Barré syndrome, the immune response damages peripheral nerves, which are the nerves that connect the central nervous system (the brain and spinal cord) to the limbs and organs. Specifically, the immune response affects a particular part of peripheral nerves called axons, which are the extensions of nerve cells (neurons) that transmit nerve impulses. Guillain-Barré syndrome can affect the neurons that control muscle movement (motor neurons); the neurons that transmit sensory signals such as pain, temperature, and touch (sensory neurons); or both. As a result, affected individuals can experience muscle weakness or lose the ability to feel certain sensations.

NIH Rare Diseases:43 Guillain-barre syndrome is a rare disorder in which the body's immune system attacks part of the peripheral nervous system. symptoms of this disorder include muscle weakness, numbness, and tingling sensations, which can increase in intensity until the muscles cannot be used at all. usually guillain-barre syndrome occurs a few days or weeks after a person has had symptoms of a viral infection. occasionally, surgery or vaccinations will trigger the syndrome. it remains unclear why only some people develop guillain-barre syndrome. most patients recover completely, although some continue to have some degree of weakness. last updated: 11/2/2009

NINDS:44 Guillain-Barr

Wikipedia:64 Guillain–Barré syndrome (GBS) (French pronunciation: more...

Description from OMIM:47 139393

Aliases & Classifications for Guillain-Barre Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 49Orphanet, 44NINDS, 57SNOMED-CT, 47OMIM, 40NCIt, 35MeSH, 27ICD9CM, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
guillain-barré syndrome:
Inheritance: Multigenic/multifactorial,Sporadic; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

guillain-barre syndrome 8 43 10 45 34 61
guillain-barré syndrome 44 49
acute inflammatory demyelinating polyradiculoneuropathy 43
acute inflammatory demyelinating polyneuropathy 43
acute autoimmune peripheral neuropathy 43
acute immune-mediated polyneuropathy 43
acute postinfectious polyneuropathy 8
guillain-barre syndrome, familial 61
acute infective polyneuritis nos 8
guillain-barré-strohl syndrome 49
acute inflammatory neuropathy 43
post-infectious polyneuritis 8
acute infective polyneuritis 8
postinfectious polyneuritis 8
acute inf. polyneuritis 8
infectious neuronitis 8
gbs 49


External Ids:

Disease Ontology8 DOID:12842
OMIM47 139393
NCIt40 C26790
MeSH35 D020275
ICD9CM27 357.0
MESH via Orphanet36 D020275
ICD10 via Orphanet26 G61.0
SNOMED-CT via Orphanet58 40956001
UMLS via Orphanet62 C0018378

Related Diseases for Guillain-Barre Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Guillain-Barre Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 159)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis b30.7MOG, MBP, CR1
2miller fisher syndrome30.7SRF
3hepatitis c30.4CCR5, MBP, CR1, CD40LG
4systemic lupus erythematosus30.4CCR5, TNFRSF1B, CR1, CD40LG, SRF
5crohn's disease30.2TNFRSF1B
6chronic inflammatory demyelinating polyradiculoneuropathy30.2PMP22, CCR5, MPZ
7lupus nephritis30.2CCR5, TNFRSF1B, CR1, CD40LG
8burkitt's lymphoma30.2TUBB, MBP, TNFRSF1B, CR1, CD40LG, SRF
9nephritis30.2CD40LG, CR1
10tuberculosis30.2SRF, CR1, TNFRSF1B, MBP
11guillain-barr� syndrome11.2
12n syndrome10.8
13neuronitis10.5
14hepatitis c virus10.4
15hepatitis a10.4
16chronic inflammatory demyelinating polyneuropathy10.4
17dysautonomia10.4
18hepatitis e10.3
19atopic dermatitis10.3
20h. pylori infection10.3
21adult syndrome10.3
22riley-day syndrome10.3
23beriberi10.3
24char syndrome10.3
25autonomic dysfunction10.3
26bickerstaff brainstem encephalitis10.3
27axonal neuropathy10.3
28evans' syndrome10.3
29plasmodium vivax malaria10.3
30cytomegalovirus infection10.3
31chronic polyradiculoneuritis10.3
32cryoglobulinemia10.2
33laryngotracheitis10.2
34marfan syndrome10.2
35membranous glomerulonephritis10.2
36focal segmental glomerulosclerosis10.2
37pulmonary tuberculosis10.2
38conversion disorder10.2
39myelitis10.2
40syringomyelia10.2
41rabies10.2
42hypertensive encephalopathy10.2
43meningoencephalitis10.2
44epiglottitis10.2
45melioidosis10.2
46pain disorder10.2
47celiac disease10.2
48hepatitis d10.2
49infectious mononucleosis10.2
50ulceroglandular tularemia10.2

Graphical network of the top 20 diseases related to Guillain-Barre Syndrome:



Diseases related to guillain-barre syndrome

Clinical Features for Guillain-Barre Syndrome

Sources:
47OMIM
See all sources

Clinical features from OMIM:

139393

Drugs & Therapeutics for Guillain-Barre Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Guillain-Barre Syndrome

Drug clinical trials:

Search ClinicalTrials for Guillain-Barre Syndrome

Search NIH Clinical Center for Guillain-Barre Syndrome

Search CenterWatch for Guillain-Barre Syndrome

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Guillain-Barre Syndrome

Anatomical Context for Guillain-Barre Syndrome

Animal Models for Guillain-Barre Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Guillain-Barre Syndrome

Sources:
51PubMed
See all sources

Articles related to Guillain-Barre Syndrome:

(show top 50)    (show all 139)
idTitleAuthorsYear
1
Epidemiological aspects of Guillain-Barre syndrome. (23821025)
2013
2
Genome Sequences of the Guillain-Barre Syndrome Outbreak-Associated Campylobacter jejuni Strains ICDCCJ07002 and ICDCCJ07004. (23704181)
2013
3
Postinfectious Guillain-Barre syndrome in a patient with methimazole-induced agranulocytosis. (24307850)
2013
4
Influenza vaccines and guillain-barre syndrome: the continuing question. (24166961)
2013
5
An unusual case of recurrent guillain-barre syndrome of a different subtype five years after initial diagnosis. (23710387)
2013
6
Hepatitis E and Guillain-Barre syndrome. (23899686)
2013
7
Efficacy of low-dose intravenous cyclophosphamide in systemic lupus erythematosus presenting with Guillain-Barre syndrome-like acute axonal neuropathies: report of two cases. (23439473)
2013
8
Syringomyelia coexisting with guillain-barre syndrome. (24236267)
2013
9
Guillain-Barre syndrome presenting with severe hydrocephalus in a child. (24082947)
2013
10
Mortality in Guillain-Barre syndrome. (23576619)
2013
11
Guillain-Barre Syndrome: Natural history and prognostic factors: a retrospective review of 106 cases. (23876199)
2013
12
Guillain-Barre Syndrome and Crohn disease: A Case Report. (24092893)
2013
13
Pharyngeal-cervical-brachial variant of Guillain-Barre syndrome. (23804237)
2013
14
Invited commentary: Influenza vaccine and Guillain-Barre syndrome--is there a risk? (22582208)
2012
15
Guillain-Barre syndrome after coronary artery bypass surgery. (22899666)
2012
16
A case of acute neurogenic weakness mimicking the axonal variant of the Guillain-Barre syndrome. (23144300)
2012
17
Prevalence of bladder dysfunction, urodynamic findings, and their correlation with outcome in Guillain-Barre syndrome. (22488834)
2012
18
Guillain-Barre syndrome after lumbar epidural block. (22379579)
2012
19
Linkage of multiple sclerosis and guillain-barre syndrome: a population-based survey in isfahan, iran. (23198139)
2012
20
Guillain-Barre syndrome during the 2009-2010 H1N1 influenza vaccination campaign: population-based surveillance among 45 million Americans. (22582209)
2012
21
Pharyngeal-cervical-brachial variant of Guillain-Barre syndrome with predominant bulbar palsy as the initial presentation of systemic lupus erythematosus and lupus nephritis: a case report. (23253247)
2012
22
Two unusual variants of Guillain-Barre syndrome. (23162026)
2012
23
TH1 and TH2 response to Campylobacter jejuni antigen in Guillain-Barre syndrome. (21482924)
2011
24
Recognizing Guillain-Barre syndrome in preschool children. (21357832)
2011
25
Keeping it simple: is there a need for the various subtyping of axonal forms of Guillain-Barre syndrome? (21551171)
2011
26
Guillain-Barre syndrome and SIADH. (21339497)
2011
27
Guillain-Barre syndrome presenting with sensory disturbance following a herpes virus infection: a case report. (22136568)
2011
28
The Diagnostic, Prognostic, and differential value of enhanced MR imaging in Guillain-Barre syndrome. (21596802)
2011
29
Measurement of motor root conduction time at the early stage of Guillain-Barre syndrome. (21426441)
2011
30
Treatment-related fluctuation in Guillain-Barre syndrome. (21897682)
2011
31
Use of the International Classification of Functioning, Disability and Health to identify preliminary comprehensive and brief core sets for Guillain Barre syndrome. (21034203)
2011
32
Genomic characterization of the Guillain-Barre syndrome-associated Campylobacter jejuni ICDCCJ07001 Isolate. (21124772)
2010
33
This disorder has some nerve: chronic pain in Guillain-Barre syndrome. (20861453)
2010
34
Magnetic resonance imaging of childhood Guillain-Barre syndrome. (20556395)
2010
35
Celiac disease associated with recurrent Guillain Barre syndrome. (21048269)
2010
36
A case of diabetic neuropathy combined with Guillain-Barre syndrome. (20526398)
2010
37
Axonal variant of Guillain-Barre syndrome associated with campylobacter infection in Bangladesh. (20625176)
2010
38
Autoantibody-mediated dysfunction of sympathetic neurons in guillain-barre syndrome. (20142528)
2010
39
Factors associated with long-term functional outcomes and psychological sequelae in Guillain-Barre syndrome. (20625757)
2010
40
Guillain-Barre syndrome associated with peginterferon alfa-2a for chronic hepatitis C: A case report. (21160989)
2010
41
A case of possible familial Guillain-Barre syndrome. (21341634)
2010
42
Guillain-Barre syndrome following cardiac surgery. Difficult diagnosis in the intensive care unit. (21048655)
2009
43
Dry beriberi mimicking the Guillain-Barre syndrome. (19608771)
2009
44
Circulating tumour necrosis factor alpha & soluble TNF receptors in patients with Guillain-Barre syndrome. (14609050)
2003
45
Guillain-Barre syndrome in patient with Burkitt's lymphoma and type 2 diabetes mellitus. (11928901)
2001
46
Differential diagnosis and treatment of conversion disorder and Guillain-Barre syndrome. (1934840)
1991
47
Quantitative determination of 7 proteins in csf of patients with Guillain Barre syndrome]. (1704305)
1990
48
Dysautonomia in Guillain Barre syndrome. (3654548)
1987
49
Laseque's sign--an important bedside diagnostic sign in acute polyradiculopathy (Guillain-Barre syndrome). (451640)
1979
50
GUILLAIN-BARRE SYNDROME ASSOCIATED WITH ULCEROGLANDULAR TULAREMIA. (14215606)
1964

Genetic Variations for Guillain-Barre Syndrome

Expression for genes affiliated with Guillain-Barre Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Guillain-Barre Syndrome

Search GEO for disease gene expression data for Guillain-Barre Syndrome.

Pathways for genes affiliated with Guillain-Barre Syndrome

Sources:
38NCBI BioSystems Database, 54Reactome, 30KEGG, 52QIAGEN
See all sources

Compounds for genes affiliated with Guillain-Barre Syndrome

Sources:
45Novoseek, 11DrugBank, 60Tocris Bioscience, 29IUPHAR, 24HMDB, 50PharmGKB
See all sources

Compounds related to Guillain-Barre Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1rantes4510.8CD40LG
2pge24510.8CCL19
3cardiolipin45 1111.8MPZ
4cerebrosides4510.7MBP, MPZ
5endotoxin4510.7SRF, TNFRSF1B
6sulfatide4510.7MBP, MPZ, PLP1
72,3-cyclic nucleotide4510.7PLP1, MPZ, MBP, MOG
8mip-3beta4510.7CCL19, CCL21
9glatiramer acetate45 1111.7MOG, MBP, MPZ, PLP1
10larc4510.6CCR5, CCL21, CCL19
11c3bot (154-182)6010.6MOG, MBP
12ivig4510.6CCR5, MBP, TNFRSF1B, CD40LG
13ono 25066010.6MOG, MBP
14nogo-66 (1-40)6010.6MOG, MBP
15mog (35-55)6010.6MOG, MBP
16plp (139-151)6010.6MOG, MBP
17cocaine45 1111.6CCR5, MBP, HCRT, CD40LG, PLP1
18ganglioside4510.6PMP22, MBP, MPZ, CD40LG, SRF
19gaba4510.6PMP22, TUBB, MBP, HCRT, PLP1
20tarc4510.6CCR5, CCL21, CCL19
21ccl345 2911.5CCL19, CCL21, CCR5
22methionine4510.5TUBB, CCR5, TNFRSF1B, CR1, MPZ, PLP1
23formaldehyde45 2411.5TUBB, MBP, CR1, CD40LG
24norepinephrine45 11 2412.5MBP, TNFRSF1B, HCRT, CD40LG, SRF
25acetylcholine45 50 29 11 2414.5MOG, MBP, HCRT, CD40LG, PLP1, SRF
26cyclosporin a45 29 6012.5CCR5, MBP, TNFRSF1B, CR1, CD40LG, SRF
27cholesterol45 29 11 2413.5CCR5, TNFRSF1B, MPZ, HCRT, PLP1, SRF
28adenylate4510.5TUBB, MBP, TNFRSF1B, CR1, HCRT, CD40LG
29forskolin45 50 1112.5PMP22, TUBB, MBP, TNFRSF1B, SRF
30aspartate4510.4CD40LG, MPZ, CCR5, PMP22
31serine4510.4PMP22, TUBB, CCR5, MOG, TNFRSF1B, MPZ
32neopterin4510.4SRF, CD40LG, TNFRSF1B
33nitric oxide45 11 2412.4TUBB, MOG, TNFRSF1B, CR1, HCRT, SRF
34arginine4510.4PMP22, CCR5, MBP, TNFRSF1B, MPZ, CD40LG
35cysteine4510.4PMP22, TUBB, CCR5, MBP, TNFRSF1B, MPZ
36glutamate4510.4TUBB, CCR5, MBP, MPZ, HCRT, CD40LG
37estrogen4510.4TUBB, CCR5, MBP, TNFRSF1B, HCRT, CD40LG
38heparin45 29 11 2413.4CCR5, CR1, CD40LG, SRF
39retinoic acid45 2411.4PMP22, CCR5, MBP, TNFRSF1B, CR1, CD40LG
40creatinine4510.3TUBB, MBP, MPZ, CD40LG, SRF
41cyclic amp45 2411.3TNFRSF1B, HCRT, PLP1, SRF
42alanine4510.3TUBB, CCR5, MBP, HCRT, CD40LG, SRF
43silver4510.3PLP1, MBP, MOG
44polyethylene glycol4510.3CD40LG, TNFRSF1B, MBP
45oxygen45 2411.3MOG, TNFRSF1B, CR1, IL22
46tyrosine4510.2TUBB, CCR5, MBP, TNFRSF1B, CR1, MPZ
47lipid4510.2PMP2, TUBB, MOG, MBP, TNFRSF1B, MPZ
48galactosylceramide4510.2MBP, CCR5
49calcium45 50 11 2413.1TUBB, CCL19, CCL21, CCR5, MOG, TNFRSF1B
50polysaccharide459.9CCR5, GALE, CR1, CD40LG

GO Terms for genes affiliated with Guillain-Barre Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Guillain-Barre Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1myelin sheathGO:04320910.4PLP1, MPZ
2compact myelinGO:04321810.2MBP, PMP22
3plasma membraneGO:0058869.5PMP22, TUBB, CCR5, MOG, MBP, TNFRSF1B

Biological processes related to Guillain-Barre Syndrome according to GeneCards/GeneDecks:

(show all 17)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of glycoprotein biosynthetic processGO:01056010.6CCL21, CCL19
2immunological synapse formationGO:00177110.5CCL21, CCL19
3dendritic cell chemotaxisGO:00240710.5CCL19, CCL21, CCR5
4negative regulation of leukocyte apoptotic processGO:200010710.5CCL19, CCL21
5axon ensheathmentGO:00836610.5PLP1, MBP
6cell maturationGO:04846910.5CCL19, CCL21, PLP1
7establishment of T cell polarityGO:00176810.5CCL19, CCL21
8response to prostaglandin E stimulusGO:03469510.4CCL21, CCL19
9positive regulation of dendritic cell antigen processing and presentationGO:00260610.4CCL19, CCL21
10synaptic transmissionGO:00726810.4PMP22, MBP, MPZ, HCRT, PLP1
11positive regulation of cell motilityGO:200014710.4CCL19, CCL21
12inflammatory responseGO:00695410.3IL22, CD40LG, TNFRSF1B, CCR5, CCL21, CCL19
13membrane organizationGO:06102410.3PMP2, MBP
14immune responseGO:00695510.3CCL19, CCL21, CCR5, MBP, TNFRSF1B, CD1E
15positive regulation of neutrophil chemotaxisGO:09002310.3CCL21, CCL19
16positive regulation of chemotaxisGO:05092110.2CCL19, CCL21
17positive regulation of receptor-mediated endocytosisGO:04826010.0CCL21, CCL19

Molecular functions related to Guillain-Barre Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of myelin sheathGO:01991110.3PLP1, MBP
2CCR7 chemokine receptor bindingGO:03173210.0CCL21, CCL19

Products for genes affiliated with Guillain-Barre Syndrome

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Sources for Guillain-Barre Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet