MCID: GLL022
MIFTS: 50

Guillain-Barre Syndrome malady

Rare diseases, Neuronal diseases, Immune diseases categories

Aliases & Classifications for Guillain-Barre Syndrome

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Sources:
60UMLS, 9Disease Ontology, 41NIH Rare Diseases, 21Genetics Home Reference, 11DISEASES, 43Novoseek, 32MedlinePlus, 47Orphanet, 3CDC, 42NINDS, 55SNOMED-CT, 27ICD9CM, 38NCIt, 33MeSH, 26ICD10 via Orphanet, 25ICD10
See all sources

Guillain-Barre Syndrome, Aliases & Descriptions:

Name: Guillain-Barre Syndrome 9 41 21 11 43 32 60
Acute Inflammatory Polyneuropathy 41 21 47
Guillain-Barré Syndrome 41 21 42
Gbs 41 21 3
Guillain-Barré Syndrome, Acute Inflammatory Demyelinating Polyradiculoneuropathic Form 41 47
Gbs, Acute Inflammatory Demyelinating Polyradiculoneuropathic Form 41 47
Acute Inflammatory Demyelinating Polyradiculoneuropathy 41 47
Acute Inflammatory Demyelinating Polyneuropathy 41 60
Acute Idiopathic Demyelinating Polyneuropathy 41 47
Aidp 41 47
Acute Autoimmune Peripheral Neuropathy 41
Landry-Guillain-Barre-Strohl Syndrome 41
Acute Immune-Mediated Polyneuropathy 41
Acute Postinfectious Polyneuropathy 9
Acute Infective Polyneuritis Nos 9
 
Guillain-Barré-Strohl Syndrome 41
Group B Streptococcal Infection 60
Landry-Guillain-Barre Syndrome 21
Acute Inflammatory Neuropathy 41
Acute Infectious Polyneuritis 21
Post-Infectious Polyneuritis 9
Acute Infective Polyneuritis 9
Landry's Ascending Paralysis 41
Post-Infective Polyneuritis 41
Postinfectious Polyneuritis 9
Acute Inf. Polyneuritis 9
Miller Fisher Syndrome 60
Infectious Neuronitis 9
Fisher Syndrome 21


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

47
acute inflammatory polyneuropathy:
Inheritance: Multigenic/multifactorial,Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: any age


External Ids:

Disease Ontology9 DOID:12842
ICD9CM27 357.0
NCIt38 C26790
MeSH33 D020275
Orphanet47 98916
ICD10 via Orphanet26 G61.0
ICD1025 G61.0

Summaries for Guillain-Barre Syndrome

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MedlinePlus:32 Guillain-barre syndrome is a rare disorder that causes your immune system to attack your peripheral nervous system (pns). the pns nerves connect your brain and spinal cord with the rest of your body. damage to these nerves makes it hard for them to transmit signals. as a result, your muscles have trouble responding to your brain. no one knows what causes the syndrome. sometimes it is triggered by an infection, surgery, or a vaccination. the first symptom is usually weakness or a tingling feeling in your legs. the feeling can spread to your upper body. in severe cases, you become almost paralyzed. this is life-threatening. you might need a respirator to breathe. symptoms usually worsen over a period of weeks and then stabilize. guillain-barre can be hard to diagnose. possible tests include nerve tests and a spinal tap. most people recover. recovery can take a few weeks to a few years. treatment can help symptoms, and may include medicines or a procedure called plasma exchange. nih: national institute of neurological disorders and stroke

MalaCards based summary: Guillain-Barre Syndrome, also known as acute inflammatory polyneuropathy, is related to polyneuropathy and neuropathy. An important gene associated with Guillain-Barre Syndrome is PMP22 (peripheral myelin protein 22), and among its related pathways is Neural Crest Differentiation. The drug immunoglobulins, intravenous and the compounds dihydroprogesterone and ganglioside have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes, and related mouse phenotypes are immune system and vision/eye.

Disease Ontology:9 An autoimmune disease of peripheral nervous system that causes body's immune system to attack part of the peripheral nervous system.

Genetics Home Reference:21 Guillain-Barré syndrome is an autoimmune disorder that affects the nerves. Autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs. In Guillain-Barré syndrome, the immune response damages peripheral nerves, which are the nerves that connect the central nervous system (the brain and spinal cord) to the limbs and organs. Specifically, the immune response affects a particular part of peripheral nerves called axons, which are the extensions of nerve cells (neurons) that transmit nerve impulses. Guillain-Barré syndrome can affect the neurons that control muscle movement (motor neurons); the neurons that transmit sensory signals such as pain, temperature, and touch (sensory neurons); or both. As a result, affected individuals can experience muscle weakness or lose the ability to feel certain sensations.

NIH Rare Diseases:41 Guillain-barre syndrome is a rare disorder in which the body's immune system attacks part of the peripheral nervous system. symptoms of this disorder include muscle weakness, numbness, and tingling sensations, which can increase in intensity until the muscles cannot be used at all. usually guillain-barre syndrome occurs a few days or weeks after a person has had symptoms of a viral infection. occasionally, surgery or vaccinations will trigger the syndrome. it remains unclear why only some people develop guillain-barre syndrome. most patients recover completely, although some continue to have some degree of weakness. last updated: 11/2/2009

CDC:3 Group B Streptococcus (group B strep, GBS) is a type of bacteria that causes illness in people of all ages. It is the most common cause of some life-threatening infections in newborns, but it can be prevented.

NINDS:42 Guillain-Barr

Wikipedia:63 Guillain?Barr more...

Related Diseases for Guillain-Barre Syndrome

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Diseases related to Guillain-Barre Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 160)
idRelated DiseaseScoreTop Affiliating Genes
1polyneuropathy31.7PMP22, MPZ
2neuropathy30.9MPZ, PMP22
3polyradiculoneuropathy30.7PMP22
4neuritis30.6MPZ, PMP22
5chronic inflammatory demyelinating polyradiculoneuropathy30.6PMP22, MPZ
6diabetic neuropathy30.5PMP22, MPZ
7neuromyelitis optica30.5MOG
8myasthenia gravis30.3PLP1, MOG
9optic neuritis30.2PLP1, MOG, MPZ
10tetanus29.9MPZ, MOG, PLP1
11demyelinating polyneuropathy11.0
12influenza10.7
13herpes simplex10.6
14ophthalmoplegia10.6
15hepatitis10.5
16leukemia10.5
17miller fisher syndrome10.5
18hepatitis e10.5
19hepatitis c virus10.5
20malaria10.5
21kozlowski warren fisher syndrome10.4
22neuropathy, inflammatory demyelinating10.4
23pharyngitis10.4
24cervicitis10.4
25encephalitis10.4
26papilledema10.4
27dysautonomia10.4
28narcolepsy 110.4HCRT
29acute disseminated encephalomyelitis10.4MOG
30neuropathy, recurrent, with pressure palsies10.4PMP22
31hodgkin lymphoma10.3
32atopic dermatitis10.3
33dermatitis10.3
34ataxia10.3
35systemic lupus erythematosus10.3
36dysautonomia, familial10.3
37chronic inflammatory demyelinating polyneuropathy10.3
38axonal neuropathy10.3
39beriberi10.3
40lupus erythematosus10.3
41lymphoblastic leukemia10.3
42polyradiculopathy10.3
43autonomic dysfunction10.3
44evans' syndrome10.3
45plasmodium vivax malaria10.3
46cytomegalovirus infection10.3
47acute motor axonal neuropathy10.3
48rheumatoid arthritis10.3
49arthritis10.3
50cryoglobulinemia10.3

Graphical network of the top 20 diseases related to Guillain-Barre Syndrome:



Diseases related to guillain-barre syndrome

Symptoms for Guillain-Barre Syndrome

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Drugs & Therapeutics for Guillain-Barre Syndrome

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Drug clinical trials:

Search ClinicalTrials for Guillain-Barre Syndrome

Search NIH Clinical Center for Guillain-Barre Syndrome

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Guillain-Barre Syndrome

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Anatomical Context for Guillain-Barre Syndrome

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MalaCards organs/tissues related to Guillain-Barre Syndrome:

31
Brain, Spinal cord, Testes, T cells

Animal Models for Guillain-Barre Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Guillain-Barre Syndrome:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.1PLP1, MOG, MPZ, TNFRSF1B
2MP:00053918.0PLP1, MOG, TNFRSF1B, PMP22
3MP:00053977.8TNFRSF1B, MPZ, MOG, PLP1
4MP:00053847.6PMP22, TNFRSF1B, MPZ, MOG, PLP1
5MP:00053697.6HCRT, PMP22, TNFRSF1B, MOG, PLP1
6MP:00053867.3PLP1, MOG, MPZ, TNFRSF1B, PMP22, HCRT
7MP:00036317.2HCRT, PMP22, TNFRSF1B, MPZ, MOG, PLP1

Publications for Guillain-Barre Syndrome

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Articles related to Guillain-Barre Syndrome:

(show top 50)    (show all 149)
idTitleAuthorsYear
1
Similarities of serum anti-ganglioside antibodies in first and third episodes of recurrent Guillain-Barre syndrome: case report. (25845761)
2015
2
Reversible cardiomyopathy in Guillain Barre syndrome. (25856949)
2014
3
Guillain-Barre syndrome associated with preceding hepatitis E virus infection. (24415572)
2014
4
Guillain-Barre Syndrome, Influenza and Influenza Vaccination--the Epidemiologic Evidence. (24415636)
2014
5
An unusual case of Guillain-Barre syndrome following toxic shock syndrome in a burned child. (24182693)
2013
6
Epidemiological aspects of Guillain-Barre syndrome. (23821025)
2013
7
Guillain-Barre syndrome in Asia. (24357682)
2013
8
Guillain-Barre syndrome following spinal anaesthesia. (23763810)
2013
9
Guillain-Barre syndrome following quadrivalent human papillomavirus vaccination among vaccine-eligible individuals in the United States. (24013368)
2013
10
A case report of overlapping Bickerstaff brainstem encephalitis and Guillain-Barre syndrome. (24463996)
2013
11
Guillain-Barre syndrome-like illness in association with electrical shock injury. (24136915)
2013
12
Genome Sequences of the Guillain-Barre Syndrome Outbreak-Associated Campylobacter jejuni Strains ICDCCJ07002 and ICDCCJ07004. (23704181)
2013
13
Postinfectious Guillain-Barre syndrome in a patient with methimazole-induced agranulocytosis. (24307850)
2013
14
Guillain Barre syndrome as a manifestation of neurological melioidosis. (24339608)
2013
15
Simple bedside predictors of mechanical ventilation in patients with Guillain-Barre syndrome. (24378177)
2013
16
Acute hepatitis E complicated by Guillain-Barre syndrome in Portugal, December 2012--a case report. (23987830)
2013
17
A multicentre prospective study of Guillain-Barre Syndrome in Japan: a focus on the incidence of subtypes. (24273220)
2013
18
Clinically silent posterior reversible encephalopathy in Guillain-Barre syndrome. (23573560)
2013
19
Influenza vaccines and guillain-barre syndrome: the continuing question. (24166961)
2013
20
An unusual case of recurrent guillain-barre syndrome of a different subtype five years after initial diagnosis. (23710387)
2013
21
Hepatitis E and Guillain-Barre syndrome. (23899686)
2013
22
Increased Guillain-Barre syndrome admissions in Shiraz, southern Iran. (24250891)
2013
23
Outcome and its predictors in Guillain-Barre syndrome. (22566597)
2012
24
Heterotopic ossification of the hips in a patient with Guillain Barre syndrome demonstrated on SPECT/CT. (22899193)
2012
25
Invited commentary: Influenza vaccine and Guillain-Barre syndrome--is there a risk? (22582208)
2012
26
Guillain-Barre syndrome after coronary artery bypass surgery. (22899666)
2012
27
Contamination with gangliosides in brain-derived rabies vaccine may trigger Guillain--Barre syndrome. (21949103)
2012
28
Guillain-Barre syndrome in colorectal cancer. (22524581)
2012
29
TH1 and TH2 response to Campylobacter jejuni antigen in Guillain-Barre syndrome. (21482924)
2011
30
Recognizing Guillain-Barre syndrome in preschool children. (21357832)
2011
31
High incidence of Guillain-Barre syndrome in children, Bangladesh. (21762603)
2011
32
Guillain-Barre syndrome, influenzalike illnesses, and influenza vaccination during seasons with and without circulating A/H1N1 viruses. (21652600)
2011
33
Keeping it simple: is there a need for the various subtyping of axonal forms of Guillain-Barre syndrome? (21551171)
2011
34
Genomic characterization of the Guillain-Barre syndrome-associated Campylobacter jejuni ICDCCJ07001 Isolate. (21124772)
2010
35
This disorder has some nerve: chronic pain in Guillain-Barre syndrome. (20861453)
2010
36
Investigation of suspected Guillain-Barre syndrome in childhood: What is the role for gadolinium enhanced magnetic resonance imaging of the spine? (20626577)
2010
37
Magnetic resonance imaging of childhood Guillain-Barre syndrome. (20556395)
2010
38
Celiac disease associated with recurrent Guillain Barre syndrome. (21048269)
2010
39
Guillain-Barre syndrome: a clinical study in King Chulalongkorn Memorial Hospital. (20973317)
2010
40
T cell reactivity to P0, P2, PMP-22, and myelin basic protein in patients with Guillain-Barre syndrome and chronic inflammatory demyelinating polyradiculoneuropathy. (16170091)
2005
41
Guillain-Barre syndrome with meningoencephalitis after Campylobacter jejuni infection. (15602203)
2004
42
Bickerstaff's brainstem encephalitis, Miller Fisher syndrome and Guillain-Barre syndrome overlap with negative anti-GQ1b antibodies. (12603297)
2003
43
Severe cardiovascular autonomic dysfunction in a patient with Guillain-Barre syndrome: a case report. (11269930)
2000
44
HLA alleles in patients with Guillain-Barre syndrome. (11776098)
2000
45
Ataxic form of Guillain-Barr syndrome associated with anti-GD1b IgG antibody. (10864627)
2000
46
Guillain-Barre syndrome following 2-chlorodeoxyadenosine treatment for Hairy Cell Leukemia. (11342351)
2000
47
A neurophysiological study in children with Miller Fisher syndrome and Guillain-Barre syndrome. (9134191)
1997
48
Dysautonomia in Guillain Barre syndrome. (3654548)
1987
49
Laseque's sign--an important bedside diagnostic sign in acute polyradiculopathy (Guillain-Barre syndrome). (451640)
1979
50
GUILLAIN-BARRE SYNDROME ASSOCIATED WITH ULCEROGLANDULAR TULAREMIA. (14215606)
1964

Variations for Guillain-Barre Syndrome

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Expression for genes affiliated with Guillain-Barre Syndrome

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Search GEO for disease gene expression data for Guillain-Barre Syndrome.

Pathways for genes affiliated with Guillain-Barre Syndrome

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Pathways related to Guillain-Barre Syndrome according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6MPZ, PMP22

Compounds for genes affiliated with Guillain-Barre Syndrome

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Sources:
43Novoseek, 49PharmGKB, 12DrugBank, 28IUPHAR, 24HMDB
See all sources

Compounds related to Guillain-Barre Syndrome according to GeneCards Suite gene sharing:

(show all 27)
idCompoundScoreTop Affiliating Genes
1dihydroprogesterone4310.0PMP22, MPZ
2ganglioside439.9MPZ, PMP22
3sulfatide439.8MPZ, PLP1
4clomipramine43 49 1211.8HCRT, MPZ
5dihydrotestosterone43 28 24 1212.6PMP22, MPZ
6silver439.6MOG, PLP1
7cocaine43 1210.5PLP1, HCRT
8c-peptide439.4HCRT, TNFRSF1B
9gaba439.4PLP1, PMP22, HCRT
102,3-cyclic nucleotide439.3PLP1, MOG, MPZ
11glatiramer acetate43 1210.2PLP1, MOG, MPZ
12acetylcholine43 49 28 24 1213.1PLP1, MOG, HCRT
13glutamate439.1HCRT, MPZ, PLP1
14steroid439.0MPZ, TNFRSF1B, PMP22
15methionine439.0PLP1, MPZ, TNFRSF1B
16curcumin438.9MPZ, TNFRSF1B
17cyclic amp43 249.9PLP1, TNFRSF1B, HCRT
18oligonucleotide438.8PLP1, TNFRSF1B, HCRT
19nitric oxide43 24 1210.7HCRT, TNFRSF1B, MOG
20retinoic acid43 249.6PLP1, TNFRSF1B, PMP22
21arginine438.6PLP1, MPZ, TNFRSF1B, PMP22
22cysteine438.6PLP1, MPZ, TNFRSF1B, PMP22
23cholesterol43 28 24 1211.5HCRT, TNFRSF1B, MPZ, PLP1
24glucose438.5MOG, TNFRSF1B, HCRT
25serine438.5PMP22, TNFRSF1B, MPZ, MOG
26calcium43 49 24 1211.1PLP1, MOG, TNFRSF1B, HCRT
27lipid437.9HCRT, TNFRSF1B, MPZ, MOG, PLP1

GO Terms for genes affiliated with Guillain-Barre Syndrome

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Cellular components related to Guillain-Barre Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1myelin sheathGO:00432099.2PLP1, MPZ
2plasma membraneGO:00058867.6PLP1, MOG, MPZ, TNFRSF1B, PMP22

Biological processes related to Guillain-Barre Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1synaptic transmissionGO:00072688.6PLP1, MPZ, PMP22, HCRT

Molecular functions related to Guillain-Barre Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural molecule activityGO:00051989.5PLP1, MPZ

Products for genes affiliated with Guillain-Barre Syndrome

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Sources for Guillain-Barre Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet