GBS
MCID: GLL022
MIFTS: 56

Guillain-Barre Syndrome (GBS) malady

Categories: Rare diseases, Neuronal diseases, Immune diseases

Aliases & Classifications for Guillain-Barre Syndrome

Aliases & Descriptions for Guillain-Barre Syndrome:

Name: Guillain-Barre Syndrome 12 50 25 52 41 42 14 69 50 25
Gbs 50 25 3
Acute Inflammatory Demyelinating Polyneuropathy 50 69
Acute Inflammatory Polyneuropathy 50 25
Fisher Syndrome 25 51
Acute Inflammatory Demyelinating Polyradiculoneuropathy 50
Acute Autoimmune Peripheral Neuropathy 50
Landry-Guillain-Barre-Strohl Syndrome 50
Acute Immune-Mediated Polyneuropathy 50
Acute Postinfectious Polyneuropathy 12
Guillain-Barré-Strohl Syndrome 50
Landry-Guillain-Barre Syndrome 25
Acute Inflammatory Neuropathy 50
Acute Infectious Polyneuritis 25
Acute Infective Polyneuritis 12
Post-Infectious Polyneuritis 12
Landry's Ascending Paralysis 50
Postinfectious Polyneuritis 12
Post-Infective Polyneuritis 50
Miller Fisher Syndrome 69
Infectious Neuronitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12842
ICD10 33 G61.0
MeSH 42 D020275
NCIt 47 C116345
UMLS 69 C0018378

Summaries for Guillain-Barre Syndrome

MedlinePlus : 41 guillain-barre syndrome is a rare disorder that causes your immune system to attack your peripheral nervous system (pns). the pns nerves connect your brain and spinal cord with the rest of your body. damage to these nerves makes it hard for them to transmit signals. as a result, your muscles have trouble responding to your brain. no one knows what causes the syndrome. sometimes it is triggered by an infection, surgery, or a vaccination. the first symptom is usually weakness or a tingling feeling in your legs. the feeling can spread to your upper body. in severe cases, you become almost paralyzed. this is life-threatening. you might need a respirator to breathe. symptoms usually worsen over a period of weeks and then stabilize. guillain-barre can be hard to diagnose. possible tests include nerve tests and a spinal tap. most people recover. recovery can take a few weeks to a few years. treatment can help symptoms, and may include medicines or a procedure called plasma exchange. nih: national institute of neurological disorders and stroke

MalaCards based summary : Guillain-Barre Syndrome, also known as gbs, is related to rabies and tularemia, and has symptoms including back pain, headache and neuralgia. An important gene associated with Guillain-Barre Syndrome is MBP (Myelin Basic Protein), and among its related pathways/superpathways are 4-1BB Pathway and HTLV-I infection. The drugs Vaccines and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include testes, heart and eye, and related phenotypes are Decreased viability and cellular

NIH Rare Diseases : 50 guillain-barré syndrome (gbs) is a rare disorder in which the body's immune system attacks part of the peripheral nervous system. symptoms include muscle weakness, numbness, and tingling sensations, which can increase in intensity until the muscles cannot be used at all. usually gbs occurs a few days or weeks after symptoms of a viral infection. it remains unclear why only some people develop gbs but there may be a genetic predisposition in some cases. diagnosed patients should be admitted to a hospital for early treatment. there is no cure for gbs, but treatments such as plasma exchange (plasmapheresis) and high dose immunoglobulins may reduce how severe the symptoms are and how long the symptoms last. recovery can take as little as a few days to as long as a few years. about 30% of those with gbs have permanent weakness. a small number may suffer a relapse many years after the initial attack. last updated: 5/12/2017

CDC : 3 Group B Streptococcus (group B strep) is a type of bacteria that causes illness in people of all ages. Also known as GBS, group B strep disease is the most common cause of severe infections in newborns that can be deadly, but it can be prevented.

NINDS : 51 Miller Fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barré syndrome. It is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes. Like Guillain-Barré syndrome, symptoms may be preceded by a viral illness. Additional symptoms include generalized muscle weakness and respiratory failure. The majority of individuals with Miller Fisher syndrome have a unique antibody that characterizes the disorder.

Disease Ontology : 12 An autoimmune disease of peripheral nervous system that causes body's immune system to attack part of the peripheral nervous system.

Wikipedia : 71 Guillain–Barré syndrome (GBS) is a rapid-onset muscle weakness caused by the immune system damaging... more...

Related Diseases for Guillain-Barre Syndrome

Diseases related to Guillain-Barre Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 269)
id Related Disease Score Top Affiliating Genes
1 rabies 29.8 CD40LG CD79A
2 tularemia 29.7 CD40LG CD79A TNF
3 celiac disease 29.3 CD40LG CD79A TNF TNFRSF1A TNFRSF1B
4 pharyngeal-cervical-brachial variant of guillain-barré syndrome 12.2
5 paraparetic variant of guillain-barré syndrome 12.1
6 miller fisher syndrome 11.9
7 neuropathy, inflammatory demyelinating 11.8
8 chronic inflammatory demyelinating polyneuropathy 11.6
9 autonomic dysfunction 11.4
10 dysautonomia 11.4
11 peripheral nervous system disease 11.1
12 dysautonomia, familial 11.1
13 acute flaccid myelitis 11.1
14 zika virus infection 11.1
15 hereditary type 2 neuropathy 10.4 MPZ PMP22
16 congenital dyserythropoietic anemia 10.3 ALB TNF
17 chrna1-related congenital myasthenic syndrome 10.3 MPZ PMP22
18 surfactant metabolism dysfunction, pulmonary, 2 10.3 MPZ PMP22
19 hypertonia 10.3 MPZ PMP22
20 atopic dermatitis 6 10.3 ALB CD79A
21 schneiderian carcinoma 10.3 ALB CD79A
22 craniorachischisis 10.3 MBP MPZ PMP22
23 influenza 10.3
24 charcot-marie-tooth disease, type 1e 10.3 MBP MPZ PMP22
25 occupational dermatitis 10.3 TNF TNFRSF1B
26 mohr-tranebjaerg syndrome 10.3 MBP MPZ PMP22
27 childhood infratentorial neoplasm 10.3 PMP22 TNF TNFRSF1B
28 korsakoff's amnesic syndrome 10.3 MBP MPZ PMP22
29 cardiac sarcoidosis 10.2 TNF TNFRSF1B
30 mikulicz disease 10.2 ALB CD79A TNF
31 bladder sarcoma 10.2 ALB CD79A TNF
32 autosomal recessive pericentral pigmentary retinopathy 10.2 TNF TNFRSF1A
33 paranasal sinus sarcoma 10.2 ALB CD79A TNF
34 familial nephrotic syndrome 10.2 ALB CD79A TNF
35 candidiasis, familial, 4, autosomal recessive 10.2 TNF TNFRSF1A
36 imaizumi kuroki syndrome 10.2 HCRT HLA-DQB1
37 biliary cirrhosis, primary, 2 10.2 ALB CD79A TNF
38 aortic valve prolapse 10.2 ALB HP PMP22
39 nephrosclerosis 10.2 CD79A HLA-DQB1 TNFRSF1B
40 multiple epiphyseal dysplasia 10.2 TNF TNFRSF1A TNFRSF1B
41 brain compression 10.2 PMP22 TNFRSF1A TNFRSF1B
42 von economo's disease 10.2 ALB MBP MPZ PMP22
43 primary ciliary dyskinesia 10.2 TNF TNFRSF1A TNFRSF1B
44 migraine with aura 10.2 HLA-DQB1 HP TNF
45 apple allergy 10.2 HLA-DQB1 HLA-DRB1
46 pigmentation disease 10.2 ALB HP TNF
47 hemoglobin d disease 10.2 HLA-DQB1 HLA-DRB1
48 neuropathy 10.1
49 hodgkin's paragranuloma 10.1 HCRT HLA-DQB1
50 bilateral parasagittal parieto-occipital polymicrogyria 10.1 HLA-DQB1 HLA-DRB1 TNF

Graphical network of the top 20 diseases related to Guillain-Barre Syndrome:



Diseases related to Guillain-Barre Syndrome

Symptoms & Phenotypes for Guillain-Barre Syndrome

UMLS symptoms related to Guillain-Barre Syndrome:


back pain, headache, neuralgia, pain, sciatica, seizures, syncope, tremor, chronic pain, vertigo/dizziness, sleeplessness, cerebellar ataxia, ophthalmoplegia

GenomeRNAi Phenotypes related to Guillain-Barre Syndrome according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.1 CD79A HLA-DQB1 MPZ
2 Decreased viability GR00381-A-3 9.1 CD79A HLA-DQB1 MPZ

MGI Mouse Phenotypes related to Guillain-Barre Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.2 ALB CD40LG CD79A HLA-DQB1 HP MBP
2 homeostasis/metabolism MP:0005376 10.18 ALB CD40LG CD79A HCRT HLA-DQB1 HP
3 behavior/neurological MP:0005386 10.13 HLA-DQB1 MBP MPZ PMP2 PMP22 TNF
4 hematopoietic system MP:0005397 10.09 CD40LG CD79A HLA-DQB1 HP MBP MPZ
5 immune system MP:0005387 10.02 CD40LG CD79A HLA-DQB1 HP MBP MPZ
6 liver/biliary system MP:0005370 9.87 CD79A HLA-DQB1 HP TNF TNFRSF1A TNFRSF1B
7 muscle MP:0005369 9.8 ALB HCRT HLA-DQB1 PMP22 TNF TNFRSF1A
8 nervous system MP:0003631 9.7 PMP2 PMP22 TNF TNFRSF1A TNFRSF1B CD40LG
9 neoplasm MP:0002006 9.63 ALB CD79A HP TNF TNFRSF1A TNFRSF1B
10 renal/urinary system MP:0005367 9.17 ALB CD40LG CD79A HLA-DQB1 HP TNFRSF1A

Drugs & Therapeutics for Guillain-Barre Syndrome

Drugs for Guillain-Barre Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 4,Phase 3,Phase 1
2 Immunoglobulins Phase 3,Phase 2
3 Antibodies Phase 3,Phase 2
4
4-Aminopyridine Approved Phase 2 504-24-5 1727
5 Complement System Proteins Phase 2
6 Potassium Channel Blockers Phase 2
7 gamma-Globulins Phase 2
8 Immunoglobulins, Intravenous Phase 2
9 Rho(D) Immune Globulin Phase 2
10 Pharmaceutical Solutions Phase 2
11
nivolumab Approved 946414-94-4
12
Thiamine Approved, Nutraceutical, Vet_approved 59-43-8 1130
13 Vitamin B Complex
14 Vitamins
15 Chelating Agents
16 Anticoagulants
17 Calcium, Dietary
18 Immunoglobulin G
19 Autoantibodies
20 Thiamin Nutraceutical
21 Citrate Nutraceutical
22
Citric Acid Nutraceutical, Vet_approved 77-92-9 311

Interventional clinical trials:

(show all 38)
id Name Status NCT ID Phase
1 Postmarketing Safety Study of Q/LAIV in Subjects 2 Through 49 Years of Age Completed NCT01985997 Phase 4
2 Efficacy and Safety Study of GB-0998 for Guillain-Barré Syndrome Completed NCT02342184 Phase 3
3 Phase III Clinical Trial of NPB-01 in Patients With Guillain-Barré Syndrome Completed NCT02221271 Phase 3
4 Additional 6-Month Safety Follow-up After Completion of Precursor Study 880801 Completed NCT01604746 Phase 3
5 Study to Evaluate the Long-term Antibody Persistence of GlaxoSmithKline (GSK) Biologicals' MenACWY-TT Vaccine (GSK134612) Versus Mencevax ACWY in Healthy Adolescents and Adults and Booster Response to MenACWY-TT Vaccine Administered at 10 Years Post-prima Active, not recruiting NCT01934140 Phase 3
6 Immunogenicity, Reactogenicity and Safety of GlaxoSmithKline (GSK) Biologicals' MenACWY-TT Vaccine Administered 6 Years Post-MenC Primary Vaccination in Healthy Subjects Who Were 12-18 Months at Primary Vaccination Active, not recruiting NCT01777308 Phase 3
7 Inhibition of Complement Activation (Eculizumab) in Guillain-Barre Syndrome Study Unknown status NCT02029378 Phase 2
8 Early Mechanical Ventilation for Guillain Barré Syndrome Completed NCT00167622 Phase 2
9 Assessment of Chronic Guillain-Barre Syndrome Improvement With Use of 4-aminopyridine Completed NCT00056810 Phase 2
10 JET-GBS - Japanese Eculizumab Trial for GBS Completed NCT02493725 Phase 2
11 Small Volume Plasma Exchange (SVPE) for Guillain-Barré Syndrome (GBS) Patients Recruiting NCT02780570 Phase 2
12 Immunomodulatory Effects of IVIg on Pregnancy Rate of Patient With Recurrent Implantation Failure Recruiting NCT03174964 Phase 2
13 Immunomodulatory Effects of IVIg on Pregnancy Rate of Patient With Recurrent Pregnancy Loss Recruiting NCT03174951 Phase 2
14 Study of GLS-5700 in Dengue Virus Seropositive Adults Recruiting NCT02887482 Phase 1
15 Study of GLS-5700 in Healthy Volunteers Active, not recruiting NCT02809443 Phase 1
16 The Changes of Cytokines in Guillain Barré Syndrome: the Correlation With Clinical Manifestations and Skin Innervation Unknown status NCT00173199
17 Change of Nerve Conduction Properties in IVIg Dependent Neuropathies Unknown status NCT01655394
18 Detection of Peripheral Blood Biomarkers in Intermediate Phase Spinal Cord Injury: Correlation With Neurological and Functional Outcomes, and Comparison to Other Central and Peripheral Neurological Conditions. Unknown status NCT01516385
19 Thiamin (Vitamin B1) Levels in Eating Disorder Adolescent Patients Unknown status NCT02164487
20 Perception and Multisensory Integration in Neurological Patients Using fMRI Unknown status NCT01469858
21 Intravenous Immunoglobulin (IVIG) Versus Plasma Exchange (PE) for Ventilated Children With Guillain Barre Syndrome (GBS) Completed NCT01306578
22 Safety Study of GBS Following Menactra Meningococcal Vaccination Completed NCT00575653
23 Effects of Robotic-assisted Gait Training In Non-Ambulatory Patients After Guillain-Barré Syndrome Completed NCT02883270
24 Prospective Study on Swallowing/Breathing Interactions in Severe Guillain Barre Syndrome. Completed NCT01024088
25 Brain Computer Interface for Communication in ICU: a Feasibility Study Completed NCT01005524
26 Regional Citrate Anticoagulation in Plasma Exchange Treatment Completed NCT01370200
27 Cervarix Long-term Safety Surveillance Completed NCT01498627
28 Surveillance for Adverse Events Following Pandemic H1N1 Immunization Completed NCT01289418
29 Surveillance for Adverse Events Following Influenza Immunization Completed NCT01318876
30 Clinical Trial to Evaluate Magtein in Older Adults Completed NCT02363634
31 Study Assessing Risk of Autoimmune Diseases in Females (9 - 25 Years) Exposed to Cervarix® in United Kingdom Completed NCT01953822
32 International Guillain-Barré Syndrome Outcome Study Recruiting NCT01582763
33 sCD163 as a Potential Biomarker in Guillain- Barré Syndrome Recruiting NCT02582853
34 Pattern of Use and Safety/Effectiveness of Nivolumab in Routine Oncology Practice Recruiting NCT02847728
35 Comparative Autoantibody and Immunologic Cell Marker Study Enrolling by invitation NCT02422875
36 Processing Integration in Neurological Patients Using fMRI Not yet recruiting NCT02722070
37 Gastrointestinal Transit Time in Patients With Guillain-Barré Syndrome Suspended NCT02459808
38 Randomized Study of Plasmapheresis or Human Immunoglobulin Infusion in Childhood Guillain-Barre Syndrome Terminated NCT00004833

Search NIH Clinical Center for Guillain-Barre Syndrome

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: guillain-barre syndrome

Genetic Tests for Guillain-Barre Syndrome

Anatomical Context for Guillain-Barre Syndrome

MalaCards organs/tissues related to Guillain-Barre Syndrome:

39
Testes, Heart, Eye, Brain, Spinal Cord, T Cells

Publications for Guillain-Barre Syndrome

Articles related to Guillain-Barre Syndrome:

(show top 50) (show all 171)
id Title Authors Year
1
The pathogenesis of demyelinating form of Guillain-Barre syndrome: proteo-peptidomic and immunological profiling of physiological fluids. ( 27143409 )
2016
2
Vision Loss in Guillain-Barre Syndrome: Is it a Complication of Guillain-Barre Syndrome or Just a Coincidence? ( 27621799 )
2016
3
Poster 344 Upper Extremity Weakness Due to Bilateral Brachial Plexopathy from Guillain-Barre Syndrome in a Cancer Patient: A Case Report. ( 27673098 )
2016
4
Facial Diplegia with Paresthesia: An Uncommon Variant of Guillain-Barre Syndrome. ( 27630886 )
2016
5
Successful treatment of Guillain-Barre syndrome by Ayurvedic treatment. ( 27143805 )
2016
6
Bilateral Ptosis as the First Presentation of Guillain-Barre Syndrome. ( 27057192 )
2016
7
Concomitant Guillain Barre Syndrome and Transverse Myelitis as Initial Neuropsychiatric Manifestation in a Case of Lupus: A Diagnostic Quandary. ( 27242943 )
2016
8
Correlation Between Daam2 Expression Changes and Demyelination in Guillain-Barre Syndrome. ( 26293489 )
2016
9
Poster 353 Acute Onset Chronic Inflammatory Demyelinating Polyneuropathy (A-CIDP) with CNS Involvement Initially Diagnosed as Guillain-Barre Syndrome (GBS): A Case Report. ( 27673107 )
2016
10
Prevalence of Autonomic Dysfunction in Hospitalized Patients with Guillain- Barre Syndrome. ( 28039863 )
2016
11
Electrophysiological observations in critically ill Guillain-Barre syndrome. ( 27625229 )
2016
12
Concurrency of Guillain-Barre syndrome and acute transverse myelitis: a case report and review of literature. ( 28018472 )
2016
13
Guillaine-barre syndrome; a rare complication of melioidosis. a case report. ( 27506202 )
2016
14
Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis and Guillain-Barre Syndrome in a 16-Month-Old Child. ( 28503601 )
2016
15
Author response: Successful treatment of Guillain-Barre syndrome by Ayurvedic treatment. ( 27621525 )
2016
16
An Overlapping Case of Miller Fisher Syndrome, Bickerstaff's Encephalitis, and the ASMAN Variant of Guillain-Barre Syndrome. ( 27974981 )
2016
17
Reducing the economic burden in management of Guillain-Barre syndrome using modified plasmapheresis. ( 27605847 )
2016
18
Guillain - Barre syndrome in a patient with acute myocardial infarction with ventricular septal defect repair treated with plasma exchange. ( 25722582 )
2015
19
A Case of Visceral Autonomic Neuropathy Complicated by Guillain-Barre Syndrome Accompanied with Cyclic Vomiting Syndrome-like Disorder in a Child. ( 26157699 )
2015
20
Outcome of Guillain-Barre syndrome patients with respiratory paralysis. ( 26475599 )
2015
21
Guillain-Barre Syndrome: Clinical Presentation, Treatment Pattern And Outcome. ( 26533694 )
2015
22
Acute toxic neuropathy mimicking guillain barre syndrome. ( 25811007 )
2015
23
Guillain-Barre syndrome in acute lymphoblastic leukemia: Causal or coincidental. ( 25878750 )
2015
24
Similarities of serum anti-ganglioside antibodies in first and third episodes of recurrent Guillain-Barre syndrome: case report. ( 25845761 )
2015
25
A rare neurological complication of typhoid fever: Guillain-Barre' syndrome. ( 25250072 )
2014
26
Relapsing Guillain-Barre syndrome in pregnancy and postpartum. ( 25221412 )
2014
27
Guillain-Barre syndrome associated with preceding hepatitis E virus infection. ( 24415572 )
2014
28
Acute Motor-Sensory Axonal Neuropathy With Hyperreflexia in Guillain-Barre Syndrome. ( 24700665 )
2014
29
Acute hemiplegia as a rare presentation of infantile Guillain-Barre syndrome. ( 25399226 )
2014
30
Association between human leukocyte antigen-DR and demylinating Guillain-Barre syndrome. ( 25274590 )
2014
31
Diagnosis of Guillain-Barre syndrome and validation of Brighton criteria. ( 24163275 )
2014
32
Guillain-Barre Syndrome, Influenza and Influenza Vaccination--the Epidemiologic Evidence. ( 24415636 )
2014
33
Demographics, clinical features, outcome and prognostic factors of Guillain-Barre syndrome in Thai children. ( 25391180 )
2014
34
Cardiac arrest after succinylcholine administration in a patient recovering from guillain-barre syndrome. ( 25327929 )
2014
35
Reversible cardiomyopathy in Guillain Barre syndrome. ( 25856949 )
2014
36
Anesthesia for cesarean section in a patient with Guillain-Barre syndrome: case report. ( 23931254 )
2013
37
Acute hepatitis E complicated by Guillain-Barre syndrome in Portugal, December 2012--a case report. ( 23987830 )
2013
38
An unusual case of Guillain-Barre syndrome following toxic shock syndrome in a burned child. ( 24182693 )
2013
39
Chart-confirmed guillain-barre syndrome after 2009 H1N1 influenza vaccination among the Medicare population, 2009-2010. ( 23652165 )
2013
40
Guillain-Barre syndrome with acute lymphoblastic leukemia. ( 24036643 )
2013
41
Guillain-Barre syndrome as a paraneoplastic manifestation of disseminated squamous cell carcinoma. ( 23729714 )
2013
42
Simple bedside predictors of mechanical ventilation in patients with Guillain-Barre syndrome. ( 24378177 )
2013
43
The role of cytomegalovirus, Haemophilus influenzae and Epstein Barr virus in Guillain Barre syndrome. ( 23852841 )
2013
44
Guillain-Barre syndrome presenting with severe hydrocephalus in a child. ( 24082947 )
2013
45
Pharyngeal-cervical-brachial variant of Guillain-Barre syndrome. ( 23804237 )
2013
46
Prevalence and profile of sleep disturbances in Guillain-Barre Syndrome: a prospective questionnaire-based study during 10 days of hospitalization. ( 22642612 )
2013
47
Clinically silent posterior reversible encephalopathy in Guillain-Barre syndrome. ( 23573560 )
2013
48
Guillain-Barre syndrome in an adult patient with Henoch-Schonlein purpura. ( 23559644 )
2013
49
Epidemiological aspects of Guillain-Barre syndrome. ( 23821025 )
2013
50
Guillain Barre syndrome as a manifestation of neurological melioidosis. ( 24339608 )
2013

Variations for Guillain-Barre Syndrome

Expression for Guillain-Barre Syndrome

Search GEO for disease gene expression data for Guillain-Barre Syndrome.

Pathways for Guillain-Barre Syndrome

Pathways related to Guillain-Barre Syndrome according to GeneCards Suite gene sharing:

(show all 23)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.51 CD40LG TNF TNFRSF1A TNFRSF1B
2 12.27 HLA-DQB1 HLA-DRB1 TNF TNFRSF1A
3 12.26 CD40LG CD79A TNF TNFRSF1A TNFRSF1B
4 12.06 HLA-DQB1 HLA-DRB1 TNF TNFRSF1A
5 11.9 CD40LG HLA-DQB1 HLA-DRB1 MPZ
6
Show member pathways
11.84 TNF TNFRSF1A TNFRSF1B
7 11.81 TNF TNFRSF1A TNFRSF1B
8 11.78 MBP MPZ PMP22
9 11.75 HLA-DQB1 HLA-DRB1 TNF
10 11.73 CD40LG TNF TNFRSF1A
11
Show member pathways
11.72 CD40LG CD79A HLA-DQB1 HLA-DRB1 TNF TNFRSF1A
12 11.7 HLA-DQB1 HLA-DRB1 TNF
13
Show member pathways
11.63 CD40LG HLA-DQB1 HLA-DRB1 TNF TNFRSF1A
14 11.56 TNF TNFRSF1A TNFRSF1B
15
Show member pathways
11.51 CD40LG TNF TNFRSF1A
16
Show member pathways
11.49 CD40LG TNF TNFRSF1A TNFRSF1B
17 11.43 TNF TNFRSF1A TNFRSF1B
18
Show member pathways
11.37 TNF TNFRSF1A TNFRSF1B
19 11.34 TNF TNFRSF1A TNFRSF1B
20
Show member pathways
11.32 CD40LG TNF TNFRSF1A TNFRSF1B
21
Show member pathways
11.23 TNF TNFRSF1A TNFRSF1B
22 11.1 CD40LG TNFRSF1A TNFRSF1B
23 11 TNF TNFRSF1A TNFRSF1B

GO Terms for Guillain-Barre Syndrome

Cellular components related to Guillain-Barre Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.46 CD40LG CD79A HLA-DRB1 TNF
2 MHC class II protein complex GO:0042613 9.26 HLA-DQB1 HLA-DRB1
3 membrane raft GO:0045121 9.26 CD79A TNF TNFRSF1A TNFRSF1B
4 myelin sheath GO:0043209 8.92 ALB MBP MPZ PMP2

Biological processes related to Guillain-Barre Syndrome according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.76 HCRT MBP MPZ PMP22
2 T cell costimulation GO:0031295 9.69 CD40LG HLA-DQB1 HLA-DRB1
3 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.54 TNF TNFRSF1B
4 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.52 HLA-DQB1 HLA-DRB1
5 myelination GO:0042552 9.5 MBP MPZ PMP22
6 positive regulation of ceramide biosynthetic process GO:2000304 9.49 TNF TNFRSF1A
7 death-inducing signaling complex assembly GO:0071550 9.48 TNF TNFRSF1A
8 regulation of establishment of endothelial barrier GO:1903140 9.43 TNF TNFRSF1A
9 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.43 TNF TNFRSF1A TNFRSF1B
10 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.4 HLA-DQB1 HLA-DRB1
11 regulation of immunoglobulin secretion GO:0051023 9.37 CD40LG TNF
12 tumor necrosis factor-mediated signaling pathway GO:0033209 9.26 CD40LG TNF TNFRSF1A TNFRSF1B
13 immune response GO:0006955 9.17 CD40LG HLA-DQB1 HLA-DRB1 MBP TNF TNFRSF1A
14 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.16 HLA-DQB1 HLA-DRB1

Molecular functions related to Guillain-Barre Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 8.62 HLA-DQB1 HLA-DRB1

Sources for Guillain-Barre Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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