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MCID: GLL022
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Guillain-barre Syndrome malady |
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Sources: 6Disease Ontology, 30NIH Rare Diseases, 23MedlinePlus, 2CDC, 31NINDS, 17Genetics Home Reference, 44Wikipedia, 22MalaCards See all sources Export this MalaCard |
MedlinePlus: Guillain-barre syndrome is a rare disorder that causes your immune system to attack your peripheral nervous system (pns). the pns nerves connect your brain and spinal cord with the rest of your body. damage to these nerves makes it hard for them to transmit signals. as a result, your muscles have trouble responding to your brain. no one knows what causes the syndrome. sometimes it is triggered by an infection, surgery or a vaccination.
the first symptom is usually weakness or a tingling feeling in your legs. the feeling can spread to your upper body. in severe cases, you become almost paralyzed. this is life-threatening. you might need a respirator to breathe. symptoms usually worsen over a period of weeks, then stabilize. most people recover. recovery can take a few weeks to a few years. treatment options during the symptom period include medicines or a procedure called plasma exchange.
nih: national institute of neurological disorders and stroke23
MalaCards: Guillain-barre Syndrome, also known as acute inflammatory polyneuropathy, is related to chronic inflammatory demyelinating polyradiculoneuropathy and miller fisher syndrome. An important gene associated with Guillain-barre Syndrome is PMP2 (peripheral myelin protein 2), and among its related pathways are Cell adhesion molecules (CAMs) and Immune response_NFAT in immune response. The drug globulin,immune (iv) and the compounds ivig and endotoxin have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and t cells, and related mouse phenotypes are renal/urinary system and hematopoietic system. Disease Ontology: An autoimmune disease of peripheral nervous system that causes body's immune system to attack part of the peripheral nervous system.6 NIH Rare Diseases: Guillain-Barre syndrome is a rare disorder in which the body's immune system attacks part of the peripheral nervous system. Symptoms of this disorder include muscle weakness, numbness, and tingling sensations, which can increase in intensity until the muscles cannot be used at all. Usually Guillain-Barre syndrome occurs a few days or weeks after a person has had symptoms of a viral infection. Occasionally, surgery or vaccinations will trigger the syndrome. It remains unclear why only some people develop Guillain-Barre syndrome. Most patients recover completely, although some continue to have some degree of weakness.30 CDC: Group B Streptococcus (group B strep, GBS) is a type of bacteria that causes illness in people of all ages. It is the most common cause of some life-threatening infections in newborns, but it can be prevented.2 NINDS: Miller Fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barr31 Genetics Home Reference: Guillain-Barré syndrome is an autoimmune disorder that affects the nerves. Autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs. In Guillain-Barré syndrome, the immune response damages peripheral nerves, which are the nerves that connect the central nervous system (the brain and spinal cord) to the limbs and organs. Specifically, the immune response affects a particular part of peripheral nerves called axons, which are the extensions of nerve cells (neurons) that transmit nerve impulses. Guillain-Barré syndrome can affect the neurons that control muscle movement (motor neurons); the neurons that transmit sensory signals such as pain, temperature, and touch (sensory neurons); or both. As a result, affected individuals can experience muscle weakness or lose the ability to feel certain sensations.17 Wikipedia: Guillain–Barré syndrome (GBS) (French pronunciation:44 more... |
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Sources: 2CDC, 43UMLS, 6Disease Ontology, 30NIH Rare Diseases, 8DISEASES, 32Novoseek , 23MedlinePlus, 17Genetics Home Reference, 31NINDS, 40SNOMED-CT, 24MeSH, 33OMIM, 19ICD9CM, 27NCIt See all sources |
Aliases & Descriptions:
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Sources: 4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT See all sources |
Approved drugs:Search CenterWatch for guillain-barre syndrome Drug clinical trials:Search ClinicalTrials for guillain-barre syndrome Search NIH Clinical Center for guillain-barre syndrome Search CenterWatch for guillain-barre syndrome Inferred drug relations via UMLS/NDF-RT:43 28 globulin,immune (iv) |
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Sources: 22MalaCards See all sources |
MalaCards organs/tissues related to guillain-barre syndrome:22Brain, Spinal cord, T cells, B cells
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Sources: 25MGI See all sources |
MGI Mouse Phenotypes related to guillain-barre syndrome:25 (show all 21)
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Sources: 35PubMed See all sources |
Articles related to guillain-barre syndrome:(show all 32)
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Sources: 1BioGPS See all sources |
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Sources: 20KEGG, 41Thomson Reuters, 37R&D Systems, 10EMD Millipore, 38Reactome, 36QIAGEN See all sources |
Pathways related to guillain-barre syndrome according to GeneDecks:(show top 50) (show all 67)
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Sources: 32Novoseek , 42Tocris Bioscience, 9DrugBank, 34PharmGKB, 18HMDB See all sources |
Compounds related to guillain-barre syndrome according to GeneDecks:(show top 50) (show all 207)
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Sources: 12Gene Ontology See all sources |
Cellular components related to guillain-barre syndrome according to GeneDecks:(show all 16)
Biological processes related to guillain-barre syndrome according to GeneDecks:(show all 29)
Molecular functions related to guillain-barre syndrome according to GeneDecks:
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