GBS
MCID: GLL022
MIFTS: 57

Guillain-Barre Syndrome (GBS) malady

Genetic diseases, Rare diseases, Neuronal diseases, Immune diseases categories
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Summaries for Guillain-Barre Syndrome

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8Disease Ontology, 21Genetics Home Reference, 43NIH Rare Diseases, 34MedlinePlus, 4CDC, 44NINDS, 65Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Guillain-barre syndrome is a rare disorder that causes your immune system to attack your peripheral nervous system (pns). the pns nerves connect your brain and spinal cord with the rest of your body. damage to these nerves makes it hard for them to transmit signals. as a result, your muscles have trouble responding to your brain. no one knows what causes the syndrome. sometimes it is triggered by an infection, surgery, or a vaccination. the first symptom is usually weakness or a tingling feeling in your legs. the feeling can spread to your upper body. in severe cases, you become almost paralyzed. this is life-threatening. you might need a respirator to breathe. symptoms usually worsen over a period of weeks and then stabilize. guillain-barre can be hard to diagnose. possible tests include nerve tests and a spinal tap. most people recover. recovery can take a few weeks to a few years. treatment can help symptoms, and may include medicines or a procedure called plasma exchange. nih: national institute of neurological disorders and stroke

MalaCards: Guillain-Barre Syndrome, also known as guillain-barré syndrome, is related to neuropathy and polyradiculoneuropathy. An important gene associated with Guillain-Barre Syndrome is MPZ (myelin protein zero), and among its related pathways is Neural Crest Differentiation. The drug immunoglobulins, intravenous and the compounds clomipramine and sulfatide have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and spinal cord, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:8 An autoimmune disease of peripheral nervous system that causes body's immune system to attack part of the peripheral nervous system.

Genetics Home Reference:21 Guillain-Barré syndrome is an autoimmune disorder that affects the nerves. Autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs. In Guillain-Barré syndrome, the immune response damages peripheral nerves, which are the nerves that connect the central nervous system (the brain and spinal cord) to the limbs and organs. Specifically, the immune response affects a particular part of peripheral nerves called axons, which are the extensions of nerve cells (neurons) that transmit nerve impulses. Guillain-Barré syndrome can affect the neurons that control muscle movement (motor neurons); the neurons that transmit sensory signals such as pain, temperature, and touch (sensory neurons); or both. As a result, affected individuals can experience muscle weakness or lose the ability to feel certain sensations.

NIH Rare Diseases:43 Guillain-barre syndrome is a rare disorder in which the body's immune system attacks part of the peripheral nervous system. symptoms of this disorder include muscle weakness, numbness, and tingling sensations, which can increase in intensity until the muscles cannot be used at all. usually guillain-barre syndrome occurs a few days or weeks after a person has had symptoms of a viral infection. occasionally, surgery or vaccinations will trigger the syndrome. it remains unclear why only some people develop guillain-barre syndrome. most patients recover completely, although some continue to have some degree of weakness. last updated: 11/2/2009

CDC:4 Group B Streptococcus (group B strep, GBS) is a type of bacteria that causes illness in people of all ages. It is the most common cause of some life-threatening infections in newborns, but it can be prevented.

NINDS:44 Miller Fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barr

Wikipedia:65 Guillain?Barr more...

Description from OMIM:47 139393

Aliases & Classifications for Guillain-Barre Syndrome

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8Disease Ontology, 43NIH Rare Diseases, 21Genetics Home Reference, 44NINDS, 10DISEASES, 45Novoseek, 49Orphanet, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 40NCIt, 47OMIM, 27ICD9CM, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Neuronal diseases, Immune diseases


Characteristics (Orphanet epidemiological data):

49
guillain-barré syndrome:
Inheritance: Multigenic/multifactorial; Prevalence: 1-9/100000; Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

guillain-barre syndrome 8 43 21 10 45 34 62
guillain-barré syndrome 21 44 49
gbs 43 21 49
acute inflammatory polyneuropathy 43 21
fisher syndrome 21 44
acute inflammatory demyelinating polyradiculoneuropathy 43
acute inflammatory demyelinating polyneuropathy 43
acute autoimmune peripheral neuropathy 43
landry-guillain-barre-strohl syndrome 43
acute immune-mediated polyneuropathy 43
acute postinfectious polyneuropathy 8
guillain-barre syndrome, familial 62
acute infective polyneuritis nos 8
guillain-barré-strohl syndrome 49
landry-guillain-barre syndrome 21
acute infectious polyneuritis 21
acute inflammatory neuropathy 43
landry's ascending paralysis 43
acute infective polyneuritis 8
post-infectious polyneuritis 8
post-infective polyneuritis 43
postinfectious polyneuritis 8
acute inf. polyneuritis 8
infectious neuronitis 8


External Ids:

Disease Ontology8 DOID:12842
NCIt40 C26790
OMIM47 139393
ICD9CM27 357.0
MeSH35 D020275
MESH via Orphanet36 D020275
ICD10 via Orphanet26 G61.0
SNOMED-CT via Orphanet59 40956001
UMLS via Orphanet63 C0018378

Related Diseases for Guillain-Barre Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Guillain-Barre Syndrome:



Diseases related to guillain-barre syndrome

Symptoms for Guillain-Barre Syndrome

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47OMIM
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Clinical features from OMIM:

139393

Drugs & Therapeutics for Guillain-Barre Syndrome

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Guillain-Barre Syndrome

Search NIH Clinical Center for Guillain-Barre Syndrome

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Guillain-Barre Syndrome

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Anatomical Context for Guillain-Barre Syndrome

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33MalaCards
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MalaCards organs/tissues related to Guillain-Barre Syndrome:

33
Testes, Brain, Spinal cord, T cells

Animal Models for Guillain-Barre Syndrome or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Guillain-Barre Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.4PLP1, MOG, MPZ, TNFRSF1B
2MP:00053978.1TNFRSF1B, MPZ, MOG, PLP1
3MP:00053917.9PLP1, MOG, TNFRSF1B, PMP22
4MP:00053697.6HCRT, PMP22, TNFRSF1B, MOG, PLP1
5MP:00053847.6PMP22, TNFRSF1B, MPZ, MOG, PLP1
6MP:00053867.3PLP1, MOG, MPZ, TNFRSF1B, PMP22, HCRT
7MP:00036317.2HCRT, PMP22, TNFRSF1B, MPZ, MOG, PLP1

Publications for Guillain-Barre Syndrome

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52PubMed
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Articles related to Guillain-Barre Syndrome:

(show top 50)    (show all 137)
idTitleAuthorsYear
1
Guillain-Barre syndrome associated with preceding hepatitis E virus infection. (24415572)
2014
2
Guillain-Barre Syndrome, Influenza and Influenza Vaccination--the Epidemiologic Evidence. (24415636)
2014
3
An unusual case of Guillain-Barre syndrome following toxic shock syndrome in a burned child. (24182693)
2013
4
Epidemiological aspects of Guillain-Barre syndrome. (23821025)
2013
5
Guillain-Barre syndrome in Asia. (24357682)
2013
6
Guillain-Barre syndrome following spinal anaesthesia. (23763810)
2013
7
Guillain-Barre syndrome following quadrivalent human papillomavirus vaccination among vaccine-eligible individuals in the United States. (24013368)
2013
8
Guillain-Barre syndrome-like illness in association with electrical shock injury. (24136915)
2013
9
Genome Sequences of the Guillain-Barre Syndrome Outbreak-Associated Campylobacter jejuni Strains ICDCCJ07002 and ICDCCJ07004. (23704181)
2013
10
Postinfectious Guillain-Barre syndrome in a patient with methimazole-induced agranulocytosis. (24307850)
2013
11
Guillain Barre syndrome as a manifestation of neurological melioidosis. (24339608)
2013
12
Simple bedside predictors of mechanical ventilation in patients with Guillain-Barre syndrome. (24378177)
2013
13
Acute hepatitis E complicated by Guillain-Barre syndrome in Portugal, December 2012--a case report. (23987830)
2013
14
A multicentre prospective study of Guillain-Barre Syndrome in Japan: a focus on the incidence of subtypes. (24273220)
2013
15
Clinically silent posterior reversible encephalopathy in Guillain-Barre syndrome. (23573560)
2013
16
Influenza vaccines and guillain-barre syndrome: the continuing question. (24166961)
2013
17
An unusual case of recurrent guillain-barre syndrome of a different subtype five years after initial diagnosis. (23710387)
2013
18
Hepatitis E and Guillain-Barre syndrome. (23899686)
2013
19
Increased Guillain-Barre syndrome admissions in Shiraz, southern Iran. (24250891)
2013
20
Outcome and its predictors in Guillain-Barre syndrome. (22566597)
2012
21
Heterotopic ossification of the hips in a patient with Guillain Barre syndrome demonstrated on SPECT/CT. (22899193)
2012
22
Invited commentary: Influenza vaccine and Guillain-Barre syndrome--is there a risk? (22582208)
2012
23
Guillain-Barre syndrome after coronary artery bypass surgery. (22899666)
2012
24
Contamination with gangliosides in brain-derived rabies vaccine may trigger Guillain--Barre syndrome. (21949103)
2012
25
Guillain-Barre syndrome in colorectal cancer. (22524581)
2012
26
TH1 and TH2 response to Campylobacter jejuni antigen in Guillain-Barre syndrome. (21482924)
2011
27
Recognizing Guillain-Barre syndrome in preschool children. (21357832)
2011
28
High incidence of Guillain-Barre syndrome in children, Bangladesh. (21762603)
2011
29
Guillain-Barre syndrome, influenzalike illnesses, and influenza vaccination during seasons with and without circulating A/H1N1 viruses. (21652600)
2011
30
Keeping it simple: is there a need for the various subtyping of axonal forms of Guillain-Barre syndrome? (21551171)
2011
31
Genomic characterization of the Guillain-Barre syndrome-associated Campylobacter jejuni ICDCCJ07001 Isolate. (21124772)
2010
32
This disorder has some nerve: chronic pain in Guillain-Barre syndrome. (20861453)
2010
33
Investigation of suspected Guillain-Barre syndrome in childhood: What is the role for gadolinium enhanced magnetic resonance imaging of the spine? (20626577)
2010
34
Magnetic resonance imaging of childhood Guillain-Barre syndrome. (20556395)
2010
35
Celiac disease associated with recurrent Guillain Barre syndrome. (21048269)
2010
36
Guillain-Barre syndrome: a clinical study in King Chulalongkorn Memorial Hospital. (20973317)
2010
37
Guillain-Barre syndrome: management and treatment options for patients with moderate to severe progression. (20968225)
2010
38
Pain in Guillain-Barre syndrome: a long-term follow-up study. (20861454)
2010
39
T cell reactivity to P0, P2, PMP-22, and myelin basic protein in patients with Guillain-Barre syndrome and chronic inflammatory demyelinating polyradiculoneuropathy. (16170091)
2005
40
Guillain-Barre syndrome with meningoencephalitis after Campylobacter jejuni infection. (15602203)
2004
41
Bickerstaff's brainstem encephalitis, Miller Fisher syndrome and Guillain-Barre syndrome overlap with negative anti-GQ1b antibodies. (12603297)
2003
42
Detection of galE gene by polymerase chain reaction in campylobacters associated with Guillain-Barre syndrome. (14602483)
2003
43
Severe cardiovascular autonomic dysfunction in a patient with Guillain-Barre syndrome: a case report. (11269930)
2000
44
HLA alleles in patients with Guillain-Barre syndrome. (11776098)
2000
45
Ataxic form of Guillain-Barr syndrome associated with anti-GD1b IgG antibody. (10864627)
2000
46
Guillain-Barre syndrome following 2-chlorodeoxyadenosine treatment for Hairy Cell Leukemia. (11342351)
2000
47
A neurophysiological study in children with Miller Fisher syndrome and Guillain-Barre syndrome. (9134191)
1997
48
Dysautonomia in Guillain Barre syndrome. (3654548)
1987
49
Laseque's sign--an important bedside diagnostic sign in acute polyradiculopathy (Guillain-Barre syndrome). (451640)
1979
50
GUILLAIN-BARRE SYNDROME ASSOCIATED WITH ULCEROGLANDULAR TULAREMIA. (14215606)
1964

Variations for Guillain-Barre Syndrome

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Expression for genes affiliated with Guillain-Barre Syndrome

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Guillain-Barre Syndrome

Search GEO for disease gene expression data for Guillain-Barre Syndrome.

Pathways for genes affiliated with Guillain-Barre Syndrome

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50PathCards, 38NCBI BioSystems Database
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Pathways related to Guillain-Barre Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.2MPZ, PMP22

Compounds for genes affiliated with Guillain-Barre Syndrome

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45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB
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Compounds related to Guillain-Barre Syndrome according to GeneCards/GeneDecks:

(show all 27)
idCompoundScoreTop Affiliating Genes
1clomipramine45 51 1111.9HCRT, MPZ
2sulfatide459.9MPZ, PLP1
3silver459.7MOG, PLP1
4c-peptide459.7HCRT, TNFRSF1B
5dihydroprogesterone459.6PMP22, MPZ
6cocaine45 1110.6PLP1, HCRT
7ganglioside459.5MPZ, PMP22
82,3-cyclic nucleotide459.4PLP1, MOG, MPZ
9glatiramer acetate45 1110.4PLP1, MOG, MPZ
10acetylcholine45 51 29 24 1113.3PLP1, MOG, HCRT
11dihydrotestosterone45 29 24 1112.2PMP22, MPZ
12methionine459.2PLP1, MPZ, TNFRSF1B
13glutamate459.2HCRT, MPZ, PLP1
14cyclic amp45 2410.2PLP1, TNFRSF1B, HCRT
15curcumin459.1MPZ, TNFRSF1B
16oligonucleotide459.1PLP1, TNFRSF1B, HCRT
17nitric oxide45 24 1111.1HCRT, TNFRSF1B, MOG
18gaba459.0PLP1, PMP22, HCRT
19glucose458.9MOG, TNFRSF1B, HCRT
20steroid458.8MPZ, TNFRSF1B, PMP22
21cholesterol45 29 24 1111.8HCRT, TNFRSF1B, MPZ, PLP1
22calcium45 51 24 1111.5PLP1, MOG, TNFRSF1B, HCRT
23arginine458.5PLP1, MPZ, TNFRSF1B, PMP22
24cysteine458.4PLP1, MPZ, TNFRSF1B, PMP22
25retinoic acid45 249.4PLP1, TNFRSF1B, PMP22
26serine458.4PMP22, TNFRSF1B, MPZ, MOG
27lipid458.3HCRT, TNFRSF1B, MPZ, MOG, PLP1

GO Terms for genes affiliated with Guillain-Barre Syndrome

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16Gene Ontology
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Cellular components related to Guillain-Barre Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1myelin sheathGO:0432099.2PLP1, MPZ
2plasma membraneGO:0058867.6PLP1, MOG, MPZ, TNFRSF1B, PMP22

Biological processes related to Guillain-Barre Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1synaptic transmissionGO:0072688.3PLP1, MPZ, PMP22, HCRT

Molecular functions related to Guillain-Barre Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural molecule activityGO:0051989.5PLP1, MPZ

Products for genes affiliated with Guillain-Barre Syndrome

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Sources for Guillain-Barre Syndrome

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet