Guttate Psoriasis malady

Wikipedia: Guttate psoriasis (also known as \"Eruptive psoriasis\") is a type of psoriasis that presents as small...⁴⁴ more...

MalaCards: Guttate Psoriasis, also known as psoriasis guttate, is related to psoriasis and crohn's disease. An important gene associated with Guttate Psoriasis is CDSN (corneodesmosin), and among its related pathways are Immune response Role of DAP12 receptors in NK cells and Immune response_Role of DAP12 receptors in NK cells. Related mouse phenotype immune system.

guttate psoriasis 30 43 psoriasis guttate 30

Diseases related to guttate psoriasis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 58)

id	Related Disease	Score	Top Affiliating Genes
1	psoriasis	30.0	NOD2, TRB@, HLA-C, KIR2DS1, CDSN, ITGAL
2	crohn's disease	27.7	ITGAL, NOD2, TRB@, HLA-C
3	pulmonary sarcoidosis	12.8	ITGAL, TRB@
4	cutaneous t cell lymphoma	12.8	TRB@, ITGAL
5	graft versus host disease	12.7	TRB@, ITGAL
6	psoriasis susceptibility 1	12.7	HLA-C, CDSN
7	primary effusion lymphoma	12.7	TRB@, ITGAL
8	birdshot chorioretinopathy	12.6	KIR2DS1, HLA-C
9	vogt-koyanagi-harada disease	12.5	KIR2DS1, HLA-C
10	anterior uveitis	12.5	HLA-C, KIR2DS1
11	tropical spastic paraparesis	12.5	HLA-C, KIR2DS1
12	leptospirosis	12.4	HLA-C, KIR2DS1
13	spastic paraparesis	12.4	HLA-C, KIR2DS1
14	relapsing-remitting multiple sclerosis	12.4	HLA-C, TRB@
15	rheumatoid arthritis, association with	12.3	NOD2, HLA-C
16	spondylarthropathy	12.3	ITGAL, TRB@, NOD2
17	primary biliary cirrhosis	12.2	ITGAL, NOD2, TRB@
18	systemic lupus erythematosus	12.2	TRB@, NOD2, ITGAL
19	primary sclerosing cholangitis	12.1	HLA-C, NOD2
20	histiocytosis	12.1	TRB@, ITGAL
21	hypersensitivity reaction type ii disease	12.1	ITGAL, TRB@, NOD2
22	sclerosing cholangitis	12.0	HLA-C, NOD2
23	cork-handlers' disease	12.0	HLA-C, ITGAL
24	atopy	12.0	CDSN, HLA-C, NOD2
25	spasticity	12.0	KIR2DS1, ITGAL, HLA-C
26	spondyloarthropathy	12.0	KIR2DS1, NOD2, HLA-C
27	cytomegalovirus infection	12.0	ITGAL, TRB@, HLA-C
28	vasculitis	12.0	TRB@, HLA-C, ITGAL
29	leprosy	12.0	NOD2, HLA-C, KIR2DS1
30	behcet's disease	12.0	HLA-C, NOD2, KIR2DS1
31	dermatitis	12.0	TRB@, CDSN, NOD2
32	ankylosing spondylitis	12.0	KIR2DS1, NOD2, HLA-C
33	spondylitis	12.0	KIR2DS1, HLA-C, NOD2
34	psoriatic arthritis	12.0	NOD2, HLA-C, TRB@
35	gastritis	12.0	KIR2DS1, HLA-C, NOD2
36	arthropathy	11.9	TRB@, NOD2, HLA-C
37	allergic rhinitis	11.9	NOD2, ITGAL, HLA-C
38	rhinitis	11.9	HLA-C, NOD2, ITGAL
39	celiac disease	11.9	NOD2, TRB@, HLA-C
40	polyposis	11.8	NOD2, HLA-C, TRB@
41	skin disease	11.7	HLA-C, CDSN, TRB@, ITGAL
42	sjogren's syndrome	11.6	TRB@, KIR2DS1, ITGAL, HLA-C
43	graves' disease	11.6	KIR2DS1, ITGAL, HLA-C, TRB@
44	uveitis	11.5	HLA-C, TRB@, KIR2DS1, NOD2
45	hepatitis c	11.5	TRB@, KIR2DS1, ITGAL, HLA-C
46	non-hodgkin lymphoma	11.5	HLA-C, TRB@, KIR2DS1, NOD2
47	myeloid leukemia	11.5	KIR2DS1, ITGAL, TRB@, HLA-C
48	hodgkin's lymphoma	11.5	NOD2, TRB@, HLA-C, KIR2DS1
49	sarcoidosis	11.4	TRB@, HLA-C, NOD2, ITGAL
50	periodontitis	11.4	NOD2, TRB@, HLA-C, ITGAL

Approved drugs:

Drug clinical trials:

MGI Mouse Phenotypes related to guttate psoriasis:

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id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system phenotype	MP:0005387	7.6	CDSN, ITGAL, HLA-C, TRB@, NOD2

Articles related to guttate psoriasis:

id	Title	Authors	Year	Affiliating Genes
1	Efalizumab-induced guttate psoriasis. Successful mana gement and re-treatment. (18569275)	Balato A.... Balato N.	2008	ITGAL
2	Distinct HLA-C/KIR genotype profile associates with guttate psoriasis. (16185272)	Holm S.J.... Sanchez F.O.	2005	HLA-C, KIR2DS1
3	A Crohn's disease-associated insertion polymorphism (3020insC) in the NOD2 gene is not associated with psoriasis vulgaris, palmo-plantar pustular psoriasis or guttate psoriasis. (12930309)	Young C.... Barker J.N.	2003	NOD2
4	HLA-C and guttate psoriasis. (11122018)	Mallon E.... Bunker C.B.	2000	HLA-C
5	Corneodesmosin (MHC S) gene in guttate psoriasis. (10470726)	Tazi-Ahnini R.... Cork M.J.	1999	CDSN
6	Evidence for a streptococcal superantigen-driven process in acute guttate psoriasis. (7593594)	Leung D.Y.... Kotb M.	1995	TRB@

Genes related to guttate psoriasis according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	CDSN	corneodesmosin	11.0	Publications
2	KIR2DS1	killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1	11.0	Publications
3	ITGAL	integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)	11.0	Publications
4	NOD2	nucleotide-binding oligomerization domain containing 2	11.0	Publications
5	HLA-C	major histocompatibility complex, class I, C	11.0	Publications
6	TRB@	T cell receptor beta locus	11.0	Publications

Pathways related to guttate psoriasis according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Immune response Role of DAP12 receptors in NK cells10	9.3	KIR2DS1, HLA-C
2	Immune response_Role of DAP12 receptors in NK cells41	9.3	HLA-C, KIR2DS1
3	Antigen processing and presentation20	9.2	HLA-C, KIR2DS1
4	Immune response Antigen presentation by MHC class I10	9.1	TRB@, HLA-C
5	Viral myocarditis20	9.0	ITGAL, HLA-C
6	Immune response_Antigen presentation by MHC class I41	8.8	HLA-C, TRB@
7	Natural killer cell mediated cytotoxicity20	8.8	HLA-C, ITGAL, KIR2DS1

Biological processes related to guttate psoriasis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	regulation of immune response	GO:050776	8.7	KIR2DS1, ITGAL, HLA-C