MCID: GYN003
MIFTS: 29

Gynandroblastoma

Categories: Rare diseases, Reproductive diseases

Aliases & Classifications for Gynandroblastoma

Summaries for Gynandroblastoma

MalaCards based summary : Gynandroblastoma, also known as ovarian gynandroblastoma, is related to sertoli-leydig cell tumor and granulosa cell tumor of the ovary. An important gene associated with Gynandroblastoma is DICER1 (Dicer 1, Ribonuclease III), and among its related pathways/superpathways is MicroRNAs in cancer. The drugs Paclitaxel and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include ovary, testis and endothelial.

Related Diseases for Gynandroblastoma

Graphical network of the top 20 diseases related to Gynandroblastoma:



Diseases related to Gynandroblastoma

Symptoms & Phenotypes for Gynandroblastoma

Drugs & Therapeutics for Gynandroblastoma

Drugs for Gynandroblastoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Etoposide Approved Phase 2 33419-42-0 36462
3
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
4
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
5
Bleomycin Approved, Investigational Phase 2 11056-06-7 5360373
6
Bevacizumab Approved, Investigational Phase 2 216974-75-3
7 Albumin-Bound Paclitaxel Phase 2
8 Antimitotic Agents Phase 2
9 Antineoplastic Agents, Phytogenic Phase 2
10 Topoisomerase Inhibitors Phase 2
11 Anti-Bacterial Agents Phase 2
12 Etoposide phosphate Phase 2
13 Antibiotics, Antitubercular Phase 2
14 Mitogens Phase 2
15 Angiogenesis Inhibitors Phase 2
16 Angiogenesis Modulating Agents Phase 2
17 Antibodies, Monoclonal Phase 2
18 Endothelial Growth Factors Phase 2
19 Immunoglobulins Phase 2
20 Antibodies Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Paclitaxel in Treating Patients With Ovarian Stromal Cancer Completed NCT00006227 Phase 2 Paclitaxel
2 Paclitaxel and Carboplatin or Bleomycin Sulfate, Etoposide Phosphate, and Cisplatin in Treating Patients With Advanced or Recurrent Sex Cord-Ovarian Stromal Tumors Recruiting NCT01042522 Phase 2 Carboplatin;Cisplatin;Etoposide Phosphate;Paclitaxel
3 Bevacizumab in Treating Patients With Recurrent Sex Cord-Stromal Tumors of the Ovary Active, not recruiting NCT00748657 Phase 2
4 International Ovarian & Testicular Stromal Tumor Registry Recruiting NCT01970696

Search NIH Clinical Center for Gynandroblastoma

Genetic Tests for Gynandroblastoma

Anatomical Context for Gynandroblastoma

MalaCards organs/tissues related to Gynandroblastoma:

38
Ovary, Testis, Endothelial

Publications for Gynandroblastoma

Articles related to Gynandroblastoma:

(show all 38)
# Title Authors Year
1
DICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry. ( 29037807 )
2017
2
Gynandroblastoma with a Juvenile Granulosa Cell Component in an Adolescent: Case Report and Literature Review. ( 27751908 )
2016
3
Gynandroblastoma With Juvenile Granulosa Cell Tumor and Concurrent Renal Cell Carcinoma: A Case Report and Review of Literature. ( 26169919 )
2015
4
Gynandroblastoma: a rare ovarian tumour with an unusual clinical presentation. ( 25935975 )
2014
5
Androgen insensitivity syndrome with gynandroblastoma and vulvar leiomyoma: case report and literature review. ( 23552209 )
2013
6
The C134W (402 C>G) FOXL2 mutation is absent in ovarian gynandroblastoma: insights into the genesis of an unusual tumour. ( 22296244 )
2012
7
Gynandroblastoma with the symptoms of infertility and secondary amenorrhea: a case report. ( 22268290 )
2011
8
Gynandroblastoma. Report of an unusual ovarian tumour and literature review. ( 18686520 )
2008
9
Recurrent gynandroblastoma of ovary-A case report: a molecular and immunohistochemical analysis. ( 17197894 )
2007
10
A cystic mass in a young woman with presumed polycystic ovarian syndrome. Gynandroblastoma. ( 16454570 )
2006
11
Ovarian gynandroblastoma with juvenile granulosa cell component and raised alpha fetoprotein. ( 16194833 )
2005
12
Gynandroblastoma of the testis in an infant: a morphological, immunohistochemical and in-situ hybridization report. ( 11943029 )
2002
13
Gynandroblastoma with elements of juvenile granulosa cell tumor. ( 9553819 )
1998
14
Gynandroblastoma in pregnancy: case report and review of literature. ( 9757751 )
1998
15
Gynandroblastoma of the ovary: a case report with an immunohistochemical and ultrastructural study. ( 9037319 )
1997
16
Gynandroblastoma with elements resembling juvenile granulosa cell tumor. ( 9421080 )
1997
17
Gynandroblastoma of ovary with juvenile granulosa cell component and heterologous intestinal type glands. ( 8884354 )
1996
18
Gynandroblastoma of the ovary. A case report. ( 1879200 )
1991
19
Gynandroblastoma of the ovary having a typical morphological appearance: a case study. ( 2067122 )
1991
20
Gynandroblastoma of the ovary. ( 3785986 )
1986
21
Granulosa cell tumor of the ovary with Sertoli-Leydig cell tumor components (gynandroblastoma). ( 4056537 )
1985
22
Gynandroblastoma of the ovary. ( 6224079 )
1983
23
Gynandroblastoma: its ultrastructure. ( 6284338 )
1982
24
Hormone studies in a gynandroblastoma. ( 658481 )
1978
25
Gynandroblastoma of the ovary. ( 1169960 )
1975
26
Gynandroblastoma of the ovary. ( 4846779 )
1974
27
Ovarian gynandroblastoma presenting with primary amenorrhea. ( 4744425 )
1973
28
Plasma steroids in two subjects with ovarian androgen-producing tumors arrhenoblastoma and gynandroblastoma. ( 4334770 )
1972
29
Spontaneous rupture of gynandroblastoma during labor. Report of a case. ( 5474001 )
1970
30
Pleomorphic granulosa-cell tumor. A borderline case resembling gynandroblastoma. ( 6017934 )
1967
31
Gynandroblastoma of the ovary: review of 8 cases from the ovarian tumor registry. ( 4293230 )
1967
32
GYNANDROBLASTOMA. REPORT OF A CASE FOLLOWED BY VAGINAL CYTOLOGY. ( 14085616 )
1963
33
Gynandroblastoma. A report of five cases, with a discussion of the histogenesis and classification of ovarian tumors. ( 14479145 )
1962
34
Gynandroblastoma of the ovary; review and report of a case. ( 13633117 )
1959
35
Feminizing ovarian gynandroblastoma. ( 13627065 )
1959
36
Case report of gynandroblastoma. ( 13606189 )
1959
37
Gynandroblastoma of the ovary. ( 18103140 )
1949
38
Gynandroblastoma of the Ovary. ( 19970711 )
1943

Variations for Gynandroblastoma

Expression for Gynandroblastoma

Search GEO for disease gene expression data for Gynandroblastoma.

Pathways for Gynandroblastoma

Pathways related to Gynandroblastoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.1 DICER1 VIM

GO Terms for Gynandroblastoma

Biological processes related to Gynandroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic DNA fragmentation GO:0006309 8.62 DICER1 FOXL2

Molecular functions related to Gynandroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein domain specific binding GO:0019904 8.96 DICER1 VIM
2 double-stranded RNA binding GO:0003725 8.62 DICER1 VIM

Sources for Gynandroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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