MCID: GYN001
MIFTS: 48

Gynecomastia malady

Categories: Endocrine diseases

Aliases & Classifications for Gynecomastia

Aliases & Descriptions for Gynecomastia:

Name: Gynecomastia 12 29 52 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12698
ICD10 33 N62
MeSH 42 D006177
NCIt 47 C3073
UMLS 69 C0018418

Summaries for Gynecomastia

MalaCards based summary : Gynecomastia is related to pseudohermaphroditism, male, with gynecomastia and aromatase excess syndrome. An important gene associated with Gynecomastia is HSD17B3 (Hydroxysteroid 17-Beta Dehydrogenase 3), and among its related pathways/superpathways are Integrated Breast Cancer Pathway and Signaling by ERBB4. The drugs Bicalutamide and Androgen Antagonists have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and skin, and related phenotypes are endocrine/exocrine gland and integument

Wikipedia : 71 Gynecomastia is a common disorder of the endocrine system in which there is a non-cancerous increase in... more...

Related Diseases for Gynecomastia

Diseases related to Gynecomastia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 242)
id Related Disease Score Top Affiliating Genes
1 pseudohermaphroditism, male, with gynecomastia 12.1
2 aromatase excess syndrome 11.9
3 infant gynecomastia 11.9
4 wilson-turner syndrome 11.6
5 spinal and bulbar muscular atrophy of kennedy 11.1
6 androgen insensitivity 11.1
7 androgen insensitivity, partial, with or without breast cancer 10.9
8 mental retardation-hypotonic facies syndrome, x-linked 10.8
9 mental retardation, x-linked, syndromic, wilson-turner type 10.8
10 46,xx testicular disorder of sex development 10.7
11 49, xxxyy syndrome 10.7
12 borjeson-forssman-lehmann syndrome 10.7
13 klinefelter's syndrome 10.7
14 alopecia, neurologic defects, and endocrinopathy syndrome 10.7
15 bartholin's gland benign neoplasm 10.3 ESR1 PGR
16 cardiovascular organ benign neoplasm 10.3 ESR1 PGR
17 appendix leiomyoma 10.3 ESR1 PGR
18 bronchus adenoma 10.3 ESR1 PGR
19 glioma 10.3 ESR1 PGR
20 ovarian benign neoplasm 10.3 ESR1 PGR
21 plexiform neurofibroma 10.3 ESR1 PGR
22 paranasal sinus disease 10.3 ESR1 PGR
23 skin sarcoma 10.3 PGR PRL
24 parathyroid adenoma 10.3 PRL SRY
25 borderline personality disorder 10.3 AR CYP19A1
26 deafness, autosomal recessive 21 10.3 ESR1 PGR
27 abdominal aortic aneurysm 10.3 PRL SRY
28 cervical lymphoepithelioma-like carcinoma 10.3 ESR1 PGR
29 histiocytic and dendritic cell cancer 10.3 ESR1 PGR
30 atypical lipomatous tumor 10.2 ESR1 PGR
31 x-linked leigh syndrome 10.2 AR ESR1
32 pediatric intraocular retinoblastoma 10.2 ESR1 PGR
33 hole retinal cyst 10.2 AR KLK3
34 congenital disorder of glycosylation, type ic 10.2 ESR1 PGR
35 intestinal perforation 10.2 ESR1 PGR
36 perlman syndrome 10.2 ESR1 PGR
37 biemond syndrome 10.2 CYP19A1 PGR
38 gastric teratoma 10.2 PRL SRY
39 polyneuropathy 10.2 CYP19A1 SHBG
40 bladder adenocarcinoma 10.2 ESR1 PGR
41 third ventricle chordoid glioma 10.2 AR CYP19A1 HSD17B3
42 colon signet ring adenocarcinoma 10.2 AR KLK3
43 limbic encephalitis 10.2 CGA HSD17B3
44 panophthalmitis 10.2 CYP19A1 PGR
45 vulva basal cell carcinoma 10.2 ESR1 PGR
46 villoglandular endometrial endometrioid adenocarcinoma 10.2 ESR1 PGR
47 vaginal adenosarcoma 10.2 ESR1 PGR
48 intraneural perineurioma 10.2 ESR1 PGR
49 benign shuddering attacks 10.2 AR CYP19A1 ESR1
50 her2-receptor negative breast cancer 10.2 CYP19A1 ESR1 PGR

Graphical network of the top 20 diseases related to Gynecomastia:



Diseases related to Gynecomastia

Symptoms & Phenotypes for Gynecomastia

MGI Mouse Phenotypes related to Gynecomastia:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.7 AR CGA CYP19A1 ESR1 PGR POMC
2 integument MP:0010771 9.43 AR CYP19A1 ESR1 PGR POMC PRL
3 neoplasm MP:0002006 9.02 AR ESR1 PGR POMC PRL

Drugs & Therapeutics for Gynecomastia

Drugs for Gynecomastia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bicalutamide Approved Phase 4,Phase 3,Phase 2 90357-06-5 56069 2375
2 Androgen Antagonists Phase 4,Phase 3,Phase 2
3 Androgens Phase 4,Phase 3,Phase 2
4 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
5 Hormones Phase 4,Phase 3,Phase 2,Phase 1
6 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
7
Tamoxifen Approved Phase 3,Phase 2 10540-29-1 2733526
8
Anastrozole Approved, Investigational Phase 3,Phase 2 120511-73-1 2187
9 Antineoplastic Agents, Hormonal Phase 3,Phase 2
10 Estrogen Antagonists Phase 3,Phase 2
11 Estrogens Phase 3,Phase 2
12 Steroid Synthesis Inhibitors Phase 3,Phase 2
13 Bone Density Conservation Agents Phase 3,Phase 2
14 Estrogen Receptor Modulators Phase 3,Phase 2
15 Selective Estrogen Receptor Modulators Phase 3,Phase 2
16 Aromatase Inhibitors Phase 3,Phase 2
17
Dutasteride Approved, Investigational Phase 2 164656-23-9 152945 6918296
18
Methyltestosterone Approved Phase 2 58-18-4 6010
19
Spironolactone Approved Phase 2,Phase 1 1952-01-7, 52-01-7 5833
20
Testolactone Approved Phase 2 968-93-4 13769
21
Testosterone Approved, Investigational Phase 2 58-22-0 6013
22 5-alpha Reductase Inhibitors Phase 2
23 Deslorelin Phase 2
24 diuretics Phase 2,Phase 1
25 Diuretics, Potassium Sparing Phase 2,Phase 1
26 Mineralocorticoid Receptor Antagonists Phase 2,Phase 1
27 Mineralocorticoids Phase 2,Phase 1
28 Natriuretic Agents Phase 2,Phase 1
29 Testosterone 17 beta-cypionate Phase 2
30
Testosterone enanthate Phase 2 315-37-7 9416
31 Testosterone undecanoate Phase 2
32 Antipsychotic Agents
33 Central Nervous System Depressants
34 Psychotropic Drugs
35 Quetiapine Fumarate 111974-72-2
36 Tranquilizing Agents

Interventional clinical trials:

(show all 14)
id Name Status NCT ID Phase
1 Compare the Value of Prophylactic Versus Therapeutic Breast Radiotherapy in CASODEX Completed NCT00590213 Phase 4
2 Gynecomastia Extension Study Completed NCT00637182 Phase 3
3 Two Different Regimens of Nolvadex in Preventing Gynecomastia Induced by Casodex 150 mg in Patients With Prostate Cancer Completed NCT00233610 Phase 3
4 Efficacy and Toxicity of Bicalutamide and Dutasteride vs. Standard Care for Prostate Cytoreduction for Brachytherapy Unknown status NCT00866554 Phase 2
5 Open Label Arimidex in Gynecomastia Completed NCT00241436 Phase 2
6 Casodex - Nolvadex Combination Completed NCT00637871 Phase 2
7 Treatment of Boys With Precocious Puberty Completed NCT00001202 Phase 2
8 Spironolactone for Pulmonary Arterial Hypertension Recruiting NCT01712620 Phase 1, Phase 2
9 Eplerenone Versus Spironolactone as Treatment of Ascites Due to Liver Cirrhosis; a Study of Efficacy and Side Effects Withdrawn NCT01801228 Phase 2
10 Targeted Fat Reduction of Pseudogynecomastia in the Male Breast Using the ZELTIQ Coolsculpting System Unknown status NCT01791660
11 Changes in Hyperprolactinemia Secondary to Antipsychotics After Switching to Quetiapine Completed NCT00952757
12 Adaptation Among Adolescents and Adults With Klinefelter Syndrome Completed NCT00896272
13 Sperm Production in Kleinfelter Syndrome Patients After Mesenchymal Stem Cell Injection Completed NCT02414295
14 UltraShape Device for Non-Invasive Fat Reduction in the Male Breast (Pseudogynecomastia) Recruiting NCT02711605

Search NIH Clinical Center for Gynecomastia

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Gynecomastia

Genetic tests related to Gynecomastia:

id Genetic test Affiliating Genes
1 Gynecomastia 29

Anatomical Context for Gynecomastia

MalaCards organs/tissues related to Gynecomastia:

39
Breast, Prostate, Skin, Lung, Testis, Liver, Spinal Cord

Publications for Gynecomastia

Articles related to Gynecomastia:

(show top 50) (show all 627)
id Title Authors Year
1
Spironolactone-induced bilateral gynecomastia in a man detected by SPECT myocardial perfusion imaging. ( 27151301 )
2016
2
Gynecomastia With Atypical Ductal Hyperplasia and Ductal Carcinoma In Situ Associated With Invasive Breast Carcinoma in a Male Patient on Antiretroviral Therapy: A Case Report. ( 26612847 )
2016
3
Incremental Role of Mammography in the Evaluation of Gynecomastia in Men Who Have Undergone Chest CT. ( 27101347 )
2016
4
Bilateral Atypical Ductal Hyperplasia with Microcalcifications in a Patient with Gynecomastia. ( 27218035 )
2016
5
Sexual function and hormone profile in young adult men with idiopathic gynecomastia: Comparison with healthy controls. ( 27177337 )
2016
6
Surgical management of gynecomastia: experience of a general surgery center. ( 27938530 )
2016
7
Endocrine and molecular investigations in a cohort of 25 adolescent males with prominent/persistent pubertal gynecomastia. ( 26845730 )
2016
8
Gynecomastia in the Ancient Egypt limestone statue of Hemiunu, the architect of the Great Pyramid of Giza (fl. 2570 BC). ( 27761884 )
2016
9
Gynecomastia Management: An Evolution and Refinement in Technique at UT Southwestern Medical Center. ( 27482482 )
2016
10
Gynecomastia and Hyperprolactinemia Secondary to Advanced Allergic Fungal Rhinosinusitis in a Pediatric Patient. ( 26768883 )
2016
11
Gynecomastia: a common indication for mammography in men of all age. ( 27467870 )
2016
12
Radiation therapy for primary breast lymphoma in male gynecomastia: a rare case report and review of the literature. ( 27225235 )
2016
13
Incidental unilateral and bilateral ductal carcinoma in situ encountered in the surgical management of young male gynecomastia. ( 27612041 )
2016
14
Breast US as primary imaging modality for diagnosing gynecomastia. ( 27734795 )
2016
15
Gynecomastia as a Paraneoplastic Symptom of Choriocarcinoma. ( 27629979 )
2016
16
Association between plasma kisspeptin levels and adolescent gynecomastia. ( 27502882 )
2016
17
Multiple Schwannomas in a Patient with Gynecomastia. ( 27988983 )
2016
18
Anatomy of the Gynecomastia Tissue and Its Clinical Significance. ( 27622122 )
2016
19
Johnson & Johnson is ordered to pay $70m to boy who developed gynecomastia. ( 27402539 )
2016
20
Combined approach for gynecomastia. ( 26955509 )
2016
21
Inherited Xq13.2-q21.31 duplication in a boy with recurrent seizures and pubertal gynecomastia: Clinical, chromosomal and aCGH characterization. ( 27617217 )
2016
22
Gynecomastia and hormones. ( 27145756 )
2016
23
Orange Peel Excision of Gland: A Novel Surgical Technique for Treatment of Gynecomastia. ( 26999715 )
2016
24
Evaluation of Serum Vitamin D Levels in Adolescents with Pubertal Gynecomastia. ( 27920626 )
2016
25
Surgical Management of Gynecomastia: Subcutaneous Mastectomy and Liposuction. ( 27679453 )
2016
26
A Novel Mutation In Human Androgen Receptor Gene Causing Partial Androgen Insensitivity Syndrome In A Patient Presenting With Gynecomastia At Puberty. ( 27087292 )
2016
27
RESPONSE TO THE ANASTROZOLE TREATMENT IN A CASE WITH PEUTZ-JEGHERS SYNDROME WHO WAS DETECTED TO HAVE LARGE CELL CALCIFYING SERTOLI CELL TUMOR AND DEVELOPED PRE-PUBERTAL GYNECOMASTIA. ( 27873740 )
2016
28
Intratubular large cell hyalinizing Sertoli cell tumor of the testis presenting with prepubertal gynecomastia: a case report. ( 27488929 )
2016
29
No-Drain Single Incision Liposuction Pull-Through Technique for Gynecomastia. ( 28032170 )
2016
30
Prepubertal Gynecomastia Due to Indirect Exposure to Nonformulary Bioidentical Hormonal Replacement Therapy: A Case Report. ( 26995893 )
2016
31
Gynecomastia Surgery-Impact on Life Quality: A Prospective Case-Control Study. ( 27404477 )
2016
32
The Satisfaction Rate among Patients and Surgeons after Periareolar Surgical Approach to Gynecomastia along with Liposuction. ( 27853693 )
2016
33
Case 32-2016. A 20-Year-Old Man with Gynecomastia. ( 27797319 )
2016
34
Who Gets Severe Gynecomastia Among HIV-Infected Children In The UK And Ireland? ( 27879556 )
2016
35
Management of Gynecomastia in Patients With Different Body Types: Considerations on 312 Consecutive Treated Cases. ( 27805927 )
2016
36
Surgical Strategies in the Treatment of Gynecomastia Grade I-II: The Combination of Liposuction and Subcutaneous Mastectomy Provides Excellent Patient Outcome and Satisfaction. ( 26557823 )
2015
37
The effect of tamoxifen on pubertal bone development in adolescents with pubertal gynecomastia. ( 26353169 )
2015
38
Large pseudoangiomatous stromal hyperplasia complicated with gynecomastia and lobular differentiation in a male breast. ( 26101734 )
2015
39
Pseudoangiomatous stromal hyperplasia with multinucleated stromal giant cells is neither exceptional in gynecomastia nor characteristic of neurofibromatosis type 1. ( 25586494 )
2015
40
The role of Ad-36 as a risk factor in males with gynecomastia. ( 26394544 )
2015
41
Laser-Assisted Liposuction Using the Novel 1,444-nm Nd:YAG Laser for the Treatment of Gynecomastia: A Pilot Study. ( 26183712 )
2015
42
A Rare Cause of Prepubertal Gynecomastia: Sertoli Cell Tumor. ( 26366315 )
2015
43
Gynecomastia induced by H1-antihistamine (ebastine) in a patient with idiopathic anaphylaxis. ( 26240797 )
2015
44
Gynecomastia and Klinefelter Syndrome. ( 26715949 )
2015
45
Primary cutaneous apocrine gland carcinoma from areolar tissue in a male patient with gynecomastia: a case report. ( 26349536 )
2015
46
Mixed gynecomastia. ( 26318471 )
2015
47
Gynecomastia in Patients with Prostate Cancer: A Systematic Review. ( 26308532 )
2015
48
Can digit ratio (2D:4D) studies be helpful in explaining the aetiology of idiopathic gynecomastia? ( 25543532 )
2015
49
GPR30 Gene Polymorphisms Are Associated with Gynecomastia Risk in Adolescents. ( 25531203 )
2015
50
The effect of gynecomastia on body image perception and gender roles in adolescents. ( 26613222 )
2015

Variations for Gynecomastia

Expression for Gynecomastia

Search GEO for disease gene expression data for Gynecomastia.

Pathways for Gynecomastia

GO Terms for Gynecomastia

Biological processes related to Gynecomastia according to GeneCards Suite gene sharing:

(show all 13)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.91 AR CGA ESR1 PGR POMC
2 regulation of transcription from RNA polymerase II promoter GO:0006357 9.83 AR CGA ESR1 SRY
3 transcription initiation from RNA polymerase II promoter GO:0006367 9.65 AR ESR1 PGR
4 cell-cell signaling GO:0007267 9.62 AR CGA PGR POMC
5 sex differentiation GO:0007548 9.49 AR SRY
6 peptide hormone processing GO:0016486 9.46 CGA POMC
7 mammary gland alveolus development GO:0060749 9.43 AR ESR1
8 androgen metabolic process GO:0008209 9.4 CYP19A1 ESR1
9 uterus development GO:0060065 9.37 CYP19A1 ESR1
10 prostate gland growth GO:0060736 9.26 AR CYP19A1
11 testosterone biosynthetic process GO:0061370 9.16 CYP19A1 HSD17B3
12 steroid hormone mediated signaling pathway GO:0043401 9.13 AR ESR1 PGR
13 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 8.62 AR PGR

Molecular functions related to Gynecomastia according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.73 AR ESR1 PGR PHF6
2 lipid binding GO:0008289 9.67 AR ESR1 PGR SHBG
3 hormone activity GO:0005179 9.58 CGA POMC PRL
4 ATPase binding GO:0051117 9.5 AR ESR1 PGR
5 steroid hormone receptor activity GO:0003707 9.43 AR ESR1 PGR
6 androgen binding GO:0005497 9.16 AR SHBG
7 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004879 9.13 AR ESR1 PGR
8 steroid binding GO:0005496 8.92 AR ESR1 PGR SHBG

Sources for Gynecomastia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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