MCID: GYN001
MIFTS: 46

Gynecomastia malady

Endocrine diseases, Reproductive diseases categories
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Summaries for Gynecomastia

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Wikipedia:65 Gynecomastia /??a?n?k??m more...

MalaCards based summary: Gynecomastia is related to leydig cell tumor and peutz-jeghers syndrome. An important gene associated with Gynecomastia is HSD17B3 (hydroxysteroid (17-beta) dehydrogenase 3), and among its related pathways are Androgen Signaling and Steroid hormone biosynthesis. The drugs tamoxifen and tamoxifen citrate and the compounds Androst-5-ene-3b,17b-diol and vorozole have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and skin.

Aliases & Classifications for Gynecomastia

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 39NCIt
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Gynecomastia, Aliases & Descriptions:

Name: Gynecomastia 8 10 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases, Reproductive diseases


External Ids:

Disease Ontology8 DOID:12698
MeSH34 D006177
NCIt39 C3073

Related Diseases for Gynecomastia

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Diseases related to Gynecomastia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 163)
idRelated DiseaseScoreTop Affiliating Genes
1leydig cell tumor30.7INHA, CYP19A1
2peutz-jeghers syndrome30.7INHA, CYP19A1
3sertoli cell tumor30.5CYP19A1, INHA
4pseudohermaphroditism30.5CYP19A1, SRY, HSD17B3
5hypogonadism30.5SHBG, CYP19A1
6hermaphroditism30.5SRY
7partial androgen insensitivity syndrome30.4CYP19A1, SHBG
8androgen insensitivity syndrome30.4SHBG, CYP19A1
9hypospadias30.4SRY, HSD17B3
10testicular cancer30.2INHA, SHBG
11breast cancer30.1CYP19A1, APOD, SHBG
12precocious puberty30.0SHBG, CYP19A1
13cryptorchidism30.0SRY, SHBG, CYP19A1
14short stature30.0CYP19A1, SHBG, SRY
15breast cyst29.8CYP19A1, APOD
16klinefelter's syndrome29.7INHA, CYP19A1, SHBG
17osteoporosis29.7CYP19A1, SHBG
18prostate cancer29.5SRY, SHBG, CYP19A1, INHA, APOD, HSD17B3
19prostatitis10.5
20hypoactive sexual desire disorder10.4SHBG
21ovarian disease10.4CYP19A1
22aromatase excess syndrome10.3
23ductal carcinoma in situ10.3
24obesity10.3
25neurofibromatosis10.3
26arthritis10.2
27rheumatoid arthritis10.2
28dysgerminoma10.2INHA, SRY
29amenorrhea10.2SRY, SHBG
30turner syndrome10.2SRY, SHBG
31hepatocellular carcinoma10.2
32leukemia10.2
33male breast cancer10.2
3417-beta hydroxysteroid dehydrogenase 3 deficiency10.2
35pseudoangiomatous stromal hyperplasia10.2
36premature ovarian failure10.2SHBG, INHA
37hypogonadism, hypergonadotropic10.2CYP19A1, SHBG
38androgenetic alopecia10.1SHBG, CYP19A1
39endometrial stromal sarcoma10.1INHA, CYP19A1
40anovulation10.1SHBG, CYP19A1
41congenital adrenal hyperplasia10.1SRY, CYP19A1
42aorta atresia10.1CYP19A1, INHA
43abrikosov's tumor10.1CYP19A1, INHA
44infant gynecomastia10.1
45hyperprolactinemia10.1
46kennedy's disease10.1
47adenoma10.1
48myeloid leukemia10.1
49seminoma10.1
50mental retardation gynecomastia obesity x-linked10.1

Graphical network of the top 20 diseases related to Gynecomastia:



Diseases related to gynecomastia

Symptoms for Gynecomastia

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Drugs & Therapeutics for Gynecomastia

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Drug clinical trials:

Search ClinicalTrials for Gynecomastia

Search NIH Clinical Center for Gynecomastia

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Gynecomastia

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Anatomical Context for Gynecomastia

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MalaCards organs/tissues related to Gynecomastia:

32
Breast, Prostate, Skin, Lung, Testis, Spinal cord, Liver, Myeloid, Heart, Bone, Thyroid, Pituitary

Animal Models for Gynecomastia or affiliated genes

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Publications for Gynecomastia

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Articles related to Gynecomastia:

(show top 50)    (show all 544)
idTitleAuthorsYear
1
Digital breast tomosynthesis of gynecomastia and associated findings-a pictorial review. (24852677)
2014
2
Bilateral pseudoangiomatous stromal hyperplasia tumors in axillary male gynecomastia: report of a case. (24676934)
2014
3
Genetic variants of estrogen beta and leptin receptors may cause gynecomastia in adolescent. (24625355)
2014
4
An Aroma of Complexity: How the Unique Genetics of Aromatase (CYP19A1) Explain Diverse Phenotypes From Hens and Hyenas to Human Gynecomastia, and Testicular and Other Tumors. (24311795)
2013
5
Prepubertal gynecomastia in two monozygotic twins with Peutz-Jeghers syndrome: clinical and surgical management. (23968963)
2013
6
18F-FDG PET/CT in detection of gynecomastia in patients with hepatocellular carcinoma. (23809917)
2013
7
A randomized trial comparing tamoxifen therapy vs. tamoxifen prophylaxis in bicalutamide-induced gynecomastia. (22502790)
2012
8
SRY-positive 46, XY male with vanishing testis syndrome, feminization and gynecomastia. (23441485)
2012
9
Euprolactinemic gynecomastia and galactorrhea with risperidone-fluvoxamine combination. (22506441)
2011
10
Unilateral gynecomastia in a young adult. (21673478)
2011
11
Gynecomastia - a difficult diagnostic problem. (21528484)
2011
12
Fibromatosis of the male breast with concurrent florid-type gynecomastia: Report of a case and review of literature. (21511401)
2011
13
Prepubertal gynecomastia in two monozygotic twins with Peutz-Jeghers syndrome: two years' treatment with anastrozole and genetic study. (21335955)
2011
14
Treatment of adolescent gynecomastia. (20223338)
2010
15
High grade gynecomastia: surgical correction and potential impact on erectile function. (20233285)
2010
16
Gynecomastia, obesity and underdeveloped testis and penis: suspected hypophysitis successfully cured with low dose of cyclosporine A. (19951616)
2009
17
It is reasonable to do endocrine investigation in gynecomastia. (18216522)
2008
18
Leydig cell hyperplasia revealed by gynecomastia. (18660859)
2008
19
Phenotype of patients with gynecomastia]. (18465688)
2008
20
Testicular interstitial cell tumor and gynecomastia in a rabbit. (17606513)
2007
21
Clonidine-induced gynecomastia and hyperprolactinemia in a 6-year-old child. (16401171)
2005
22
Gynecomastia and mucosal lentigines in an 8-year-old boy. (16198789)
2005
23
Sertoli cell tumor causing prepubertal gynecomastia in a boy with peutz-jeghers syndrome: the outcome of 1-year treatment with the aromatase inhibitor testolactone. (15947469)
2005
24
Possible involvement of aromatase overexpression induced by cyclo-oxygenase-2 in the pathogenesis of idiopathic gynecomastia. (16392624)
2005
25
A case-control study of gynecomastia in HIV-1-infected patients receiving HAART. (14959701)
2004
26
Sonography of pediatric male breast masses: gynecomastia and beyond. (15378216)
2004
27
Psychosocial adjustment of two boys with gynecomastia. (15151602)
2004
28
Gynecomastia following chemotherapy for testicular cancer. (12660472)
2003
29
Expression of BRCA1 and BRCA2 in male breast cancers and gynecomastias. (12680164)
2003
30
Gynecomastia in male HIV patients MRI and US findings. (12213363)
2002
31
Gynecomastia: complications of the subcutaneous mastectomy. (11842972)
2002
32
Occult Leydig cell tumor in a patient with gynecomastia. (11497478)
2001
33
Isolated relapse of acute lymphoblastic leukemia in the breast masquerading as gynecomastia. (10896624)
2000
34
Treatment of adolescent gynecomastia using a bipedicle technique. (9523606)
1998
35
Gynecomastia following spinal cord disorder. (9161376)
1997
36
Evaluation and treatment of gynecomastia. (9105209)
1997
37
Gynecomastia with metoclopramide use in pediatric patients. (9077721)
1997
38
Report of an XX male with hypospadias and pubertal gynecomastia, SRY gene negative in blood leukocytes but SRY gene positive in testicular cells. (9030973)
1997
39
Prepubertal gynecomastia during growth hormone therapy. (7699552)
1995
40
Case report: finasteride-induced gynecomastia in a 62-year-old man. (7539584)
1995
41
Correction of gynecomastia with an inframammary incision and subsequent scar. (7480316)
1995
42
Medications that cause gynecomastia. (8248425)
1993
43
Metastatic hepatocellular carcinoma of the breast, simulating gynecomastia: diagnosis by fine-needle aspiration biopsy. (1334827)
1992
44
Infantile gynecomastia with bloody nipple discharge. (1552426)
1992
45
Mineralocorticoids in the mechanism of gynecomastia in adrenal hyperplasia caused by 11 beta-hydroxylase deficiency. (1993958)
1991
46
Re: Liposuction of giant lipoma and the treatment of gynecomastia without sharp excision. (2029145)
1991
47
Hormonal studies and physical maturation in adolescent gynecomastia. (2137877)
1990
48
The occurrence of gynecomastia upon withdrawal of clomiphene citrate treatment for idiopathic oligospermia. (6773824)
1980
49
Leydig-cell tumor of the testis with gynecomastia and elevated estrogen levels. (868795)
1977
50
Mediastinal seminoma. Associated with exophthalmos and gynecomastia. (4819703)
1974

Variations for Gynecomastia

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Expression for genes affiliated with Gynecomastia

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Expression patterns in normal tissues for genes affiliated with Gynecomastia

Search GEO for disease gene expression data for Gynecomastia.

Pathways for genes affiliated with Gynecomastia

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Pathways related to Gynecomastia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5SRY, SHBG
2
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism37
9.4HSD17B3, CYP19A1
3
Show member pathways
9.4HSD17B3, CYP19A1
4
Show member pathways
Estrogen biosynthesis60
Androstenedione and testosterone biosynthesis and metabolism p.160
9.4HSD17B3, CYP19A1
5
Show member pathways
estradiol biosynthesis II37
androgen biosynthesis37
estradiol biosynthesis I37
progesterone biosynthesis37
9.4HSD17B3, CYP19A1
69.3CYP19A1, INHA

Compounds for genes affiliated with Gynecomastia

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Compounds related to Gynecomastia according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1Androst-5-ene-3b,17b-diol249.9HSD17B3, CYP19A1
2vorozole449.8SHBG, CYP19A1
3formestane449.8CYP19A1, SHBG
4ment449.8CYP19A1, SHBG
5atrazine449.8SHBG, CYP19A1
6androstenediol449.7SHBG, CYP19A1
7carbimazole44 1110.7SHBG, CYP19A1
8nandrolone44 2410.7SHBG, CYP19A1
9goserelin44 28 1111.7SHBG, CYP19A1
10megestrol acetate449.7CYP19A1, SHBG
115alpha-androstane-3alpha,17beta-diol449.7CYP19A1, SHBG
12leuprolide acetate449.7SHBG, CYP19A1
13finasteride44 61 24 1112.7CYP19A1, SHBG
14exemestane44 50 61 1112.7SHBG, CYP19A1
15anastrozole44 50 1111.7SHBG, CYP19A1
16toremifene44 1110.7CYP19A1, SHBG
17naringenin44 1110.7CYP19A1, SHBG
18Testosterone sulfate249.7CYP19A1, HSD17B3
19clomiphene citrate449.7CYP19A1, SHBG
20tibolone449.7SHBG, CYP19A1
21danazol44 24 1111.7SHBG, CYP19A1
22cyproteroneacetate449.7SHBG, CYP19A1
23letrozole44 50 61 1112.6SHBG, CYP19A1
24levonorgestrel44 61 28 1112.6CYP19A1, SHBG
2517-hydroxyprogesterone44 2410.6SHBG, CYP19A1
26flutamide44 61 1111.6SHBG, CYP19A1
27estrone sulfate44 2410.6CYP19A1, SHBG
2825-hydroxyvitamin d449.6SHBG, CYP19A1
2917beta-hydroxysteroid449.6CYP19A1, HSD17B3
30diethylstilbestrol44 28 1111.6SHBG, CYP19A1
313beta-hydroxysteroid449.5INHA, CYP19A1
32ketoconazole44 28 24 1112.5CYP19A1, SHBG
33dehydroepiandrosterone sulfate449.5CYP19A1, SHBG
34biotin44 24 1111.4INHA, SHBG, SRY
35progestins449.4SHBG, CYP19A1
36estrone44 28 24 1112.3HSD17B3, SHBG, CYP19A1
37raloxifene44 50 28 1112.3CYP19A1, SHBG
38progestin449.3SHBG, CYP19A1
39metformin44 50 1111.2SHBG, CYP19A1
40gnrh449.2SHBG, INHA, CYP19A1
41agarose449.1INHA, APOD, SRY
42dhea449.0SHBG, CYP19A1
43androstenedione44 249.9CYP19A1, INHA, SHBG, HSD17B3
44tamoxifen44 50 28 1111.8CYP19A1, SHBG, APOD
45dihydrotestosterone44 28 24 1111.5CYP19A1, SHBG, APOD, SRY
46progesterone44 28 61 24 1112.4CYP19A1, INHA, SHBG, APOD
47estradiol44 24 1110.4SRY, HSD17B3, SHBG, INHA, CYP19A1
48estrogen448.0CYP19A1, INHA, SHBG, HSD17B3, APOD
49steroid448.0SRY, APOD, SHBG, INHA, CYP19A1
50testosterone44 61 24 1110.6SRY, APOD, HSD17B3, SHBG, INHA, CYP19A1

GO Terms for genes affiliated with Gynecomastia

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Biological processes related to Gynecomastia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid metabolic processGO:0082029.4HSD17B3, CYP19A1

Products for genes affiliated with Gynecomastia

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Sources for Gynecomastia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet