Aliases & Classifications for Gynecomastia

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 61UMLS, 56SNOMED-CT, 39NCIt, 33MeSH
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Aliases & Descriptions for Gynecomastia:

Name: Gynecomastia 8 10 44 61


External Ids:

Disease Ontology8 DOID:12698
NCIt39 C3073
MeSH33 D006177

Summaries for Gynecomastia

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Wikipedia:64 Gynecomastia /??a?n?k??m more...

MalaCards based summary: Gynecomastia is related to peutz-jeghers syndrome and leydig cell tumor. An important gene associated with Gynecomastia is HSD17B3 (hydroxysteroid (17-beta) dehydrogenase 3), and among its related pathways are Androgen Signaling and Steroid hormone biosynthesis. The drugs tamoxifen and tamoxifen citrate and the compounds Androst-5-ene-3b,17b-diol and vorozole have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and skin.

Related Diseases for Gynecomastia

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Diseases related to Gynecomastia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 160)
idRelated DiseaseScoreTop Affiliating Genes
1peutz-jeghers syndrome30.8CYP19A1, INHA
2leydig cell tumor30.7INHA, CYP19A1
3sertoli cell tumor30.5INHA, CYP19A1
4pseudohermaphroditism30.5CYP19A1, HSD17B3, SRY
5hypogonadism30.5CYP19A1, SHBG
6androgen insensitivity, partial, with or without breast cancer30.5CYP19A1, SHBG
7hypospadias30.4HSD17B3, SRY
8androgen insensitivity30.3SHBG, HSD17B3, SRY
9complete androgen insensitivity syndrome30.2CYP19A1, SHBG
10testicular cancer30.2SHBG, INHA
11breast cancer30.1APOD, SHBG, CYP19A1
12precocious puberty30.0SHBG, CYP19A1
13cryptorchidism30.0SRY, SHBG, CYP19A1
14breast cyst29.8APOD, CYP19A1
15klinefelter's syndrome29.7CYP19A1, INHA, SHBG
16osteoporosis29.7SHBG, CYP19A1
17prostate cancer29.5CYP19A1, INHA, SHBG, HSD17B3, APOD, SRY
18infertility29.4SRY, SHBG, INHA, CYP19A1
19prostatitis10.5
20hermaphroditism10.4SRY
21hypoactive sexual desire disorder10.4SHBG
22pseudohermaphroditism, male, with gynecomastia10.4
23ovarian disease10.3CYP19A1
24aromatase excess syndrome10.3
25spinal and bulbar muscular atrophy of kennedy10.3
26wilson-turner syndrome10.3
27ductal carcinoma in situ10.3
28neurofibromatosis10.3
29obesity10.3
30arthritis10.3
31rheumatoid arthritis10.2
32pseudoangiomatous stromal hyperplasia10.2
33dysgerminoma10.2INHA, SRY
34amenorrhea10.2SHBG, SRY
35turner syndrome10.2SRY, SHBG
36hepatocellular carcinoma10.2
37leukemia10.2
38infant gynecomastia10.2
39premature ovarian failure10.2INHA, SHBG
40alopecia, androgenetic, 110.1SHBG, CYP19A1
41endometrial stromal sarcoma10.1CYP19A1, INHA
42congenital adrenal hyperplasia10.1SRY, CYP19A1
43anovulation10.1CYP19A1, SHBG
44hyperprolactinemia10.1
45borjeson-forssman-lehmann syndrome10.1
46adenoma10.1
47myeloid leukemia10.1
48seminoma10.1
49abrikosov's tumor10.1CYP19A1, INHA
50azoospermia10.1SHBG, SRY

Graphical network of the top 20 diseases related to Gynecomastia:



Diseases related to gynecomastia

Symptoms for Gynecomastia

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Drugs & Therapeutics for Gynecomastia

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Drug clinical trials:

Search ClinicalTrials for Gynecomastia

Search NIH Clinical Center for Gynecomastia

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Gynecomastia

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Anatomical Context for Gynecomastia

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MalaCards organs/tissues related to Gynecomastia:

31
Breast, Prostate, Skin, Lung, Testis, Spinal cord, Liver, Myeloid, Heart, Bone, Thyroid, Pituitary

Animal Models for Gynecomastia or affiliated genes

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Publications for Gynecomastia

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Articles related to Gynecomastia:

(show top 50)    (show all 563)
idTitleAuthorsYear
1
Pseudoangiomatous stromal hyperplasia with multinucleated stromal giant cells is neither exceptional in gynecomastia nor characteristic of neurofibromatosis type 1. (25586494)
2015
2
Can digit ratio (2D:4D) studies be helpful in explaining the aetiology of idiopathic gynecomastia? (25543532)
2015
3
Digital breast tomosynthesis of gynecomastia and associated findings-a pictorial review. (24852677)
2014
4
Clinical and surgical management of unilateral prepubertal gynecomastia. (25437663)
2014
5
Bilateral pseudoangiomatous stromal hyperplasia tumors in axillary male gynecomastia: report of a case. (24676934)
2014
6
Commentary on "gynecomastia: etiologies, clinical presentations, diagnosis, and management". (24389787)
2014
7
Genetic variants of estrogen beta and leptin receptors may cause gynecomastia in adolescent. (24625355)
2014
8
An Aroma of Complexity: How the Unique Genetics of Aromatase (CYP19A1) Explain Diverse Phenotypes From Hens and Hyenas to Human Gynecomastia, and Testicular and Other Tumors. (24311795)
2013
9
Prepubertal gynecomastia in two monozygotic twins with Peutz-Jeghers syndrome: clinical and surgical management. (23968963)
2013
10
18F-FDG PET/CT in detection of gynecomastia in patients with hepatocellular carcinoma. (23809917)
2013
11
A randomized trial comparing tamoxifen therapy vs. tamoxifen prophylaxis in bicalutamide-induced gynecomastia. (22502790)
2012
12
Surgical treatment of gynecomastia: complications and outcomes. (21712702)
2012
13
SRY-positive 46, XY male with vanishing testis syndrome, feminization and gynecomastia. (23441485)
2012
14
Euprolactinemic gynecomastia and galactorrhea with risperidone-fluvoxamine combination. (22506441)
2011
15
Unilateral gynecomastia in a young adult. (21673478)
2011
16
Gynecomastia - a difficult diagnostic problem. (21528484)
2011
17
Fibromatosis of the male breast with concurrent florid-type gynecomastia: Report of a case and review of literature. (21511401)
2011
18
Treatment of adolescent gynecomastia. (20223338)
2010
19
High grade gynecomastia: surgical correction and potential impact on erectile function. (20233285)
2010
20
Gynecomastia, obesity and underdeveloped testis and penis: suspected hypophysitis successfully cured with low dose of cyclosporine A. (19951616)
2009
21
It is reasonable to do endocrine investigation in gynecomastia. (18216522)
2008
22
Leydig cell hyperplasia revealed by gynecomastia. (18660859)
2008
23
Phenotype of patients with gynecomastia]. (18465688)
2008
24
Testicular interstitial cell tumor and gynecomastia in a rabbit. (17606513)
2007
25
Clonidine-induced gynecomastia and hyperprolactinemia in a 6-year-old child. (16401171)
2005
26
Gynecomastia and mucosal lentigines in an 8-year-old boy. (16198789)
2005
27
Sertoli cell tumor causing prepubertal gynecomastia in a boy with peutz-jeghers syndrome: the outcome of 1-year treatment with the aromatase inhibitor testolactone. (15947469)
2005
28
Possible involvement of aromatase overexpression induced by cyclo-oxygenase-2 in the pathogenesis of idiopathic gynecomastia. (16392624)
2005
29
A case-control study of gynecomastia in HIV-1-infected patients receiving HAART. (14959701)
2004
30
Sonography of pediatric male breast masses: gynecomastia and beyond. (15378216)
2004
31
Psychosocial adjustment of two boys with gynecomastia. (15151602)
2004
32
Gynecomastia following chemotherapy for testicular cancer. (12660472)
2003
33
Gynecomastia in male HIV patients MRI and US findings. (12213363)
2002
34
Gynecomastia: complications of the subcutaneous mastectomy. (11842972)
2002
35
Occult Leydig cell tumor in a patient with gynecomastia. (11497478)
2001
36
Isolated relapse of acute lymphoblastic leukemia in the breast masquerading as gynecomastia. (10896624)
2000
37
Treatment of adolescent gynecomastia using a bipedicle technique. (9523606)
1998
38
Gynecomastia following spinal cord disorder. (9161376)
1997
39
Evaluation and treatment of gynecomastia. (9105209)
1997
40
Gynecomastia with metoclopramide use in pediatric patients. (9077721)
1997
41
Prepubertal gynecomastia during growth hormone therapy. (7699552)
1995
42
Case report: finasteride-induced gynecomastia in a 62-year-old man. (7539584)
1995
43
Correction of gynecomastia with an inframammary incision and subsequent scar. (7480316)
1995
44
Nipple placement in simple mastectomy with free nipple grafting for severe gynecomastia. (7972427)
1994
45
Metastatic hepatocellular carcinoma of the breast, simulating gynecomastia: diagnosis by fine-needle aspiration biopsy. (1334827)
1992
46
Mineralocorticoids in the mechanism of gynecomastia in adrenal hyperplasia caused by 11 beta-hydroxylase deficiency. (1993958)
1991
47
Re: Liposuction of giant lipoma and the treatment of gynecomastia without sharp excision. (2029145)
1991
48
The occurrence of gynecomastia upon withdrawal of clomiphene citrate treatment for idiopathic oligospermia. (6773824)
1980
49
Leydig-cell tumor of the testis with gynecomastia and elevated estrogen levels. (868795)
1977
50
Mediastinal seminoma. Associated with exophthalmos and gynecomastia. (4819703)
1974

Variations for Gynecomastia

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Expression for genes affiliated with Gynecomastia

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Search GEO for disease gene expression data for Gynecomastia.

Pathways for genes affiliated with Gynecomastia

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Pathways related to Gynecomastia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5SRY, SHBG
2
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism36
9.4HSD17B3, CYP19A1
3
Show member pathways
9.4HSD17B3, CYP19A1
4
Show member pathways
Estrogen biosynthesis59
Androstenedione and testosterone biosynthesis and metabolism p.159
9.4HSD17B3, CYP19A1
5
Show member pathways
estradiol biosynthesis II36
androgen biosynthesis36
estradiol biosynthesis I36
progesterone biosynthesis36
9.4HSD17B3, CYP19A1
69.3CYP19A1, INHA

Compounds for genes affiliated with Gynecomastia

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Compounds related to Gynecomastia according to GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1Androst-5-ene-3b,17b-diol249.9HSD17B3, CYP19A1
2vorozole449.8CYP19A1, SHBG
3formestane449.8SHBG, CYP19A1
4ment449.8CYP19A1, SHBG
5atrazine449.8CYP19A1, SHBG
6androstenediol449.7SHBG, CYP19A1
7carbimazole44 1110.7SHBG, CYP19A1
8nandrolone44 2410.7SHBG, CYP19A1
9goserelin44 28 1111.7CYP19A1, SHBG
10megestrol acetate449.7CYP19A1, SHBG
115alpha-androstane-3alpha,17beta-diol449.7SHBG, CYP19A1
12leuprolide acetate449.7SHBG, CYP19A1
13finasteride44 60 24 1112.7SHBG, CYP19A1
14exemestane44 50 60 1112.7SHBG, CYP19A1
15anastrozole44 50 1111.7CYP19A1, SHBG
16clomiphene citrate449.7SHBG, CYP19A1
17naringenin44 1110.7SHBG, CYP19A1
18Testosterone sulfate249.7HSD17B3, CYP19A1
19toremifene44 1110.7CYP19A1, SHBG
20tibolone449.7SHBG, CYP19A1
21danazol44 24 1111.7CYP19A1, SHBG
22cyproteroneacetate449.7SHBG, CYP19A1
23letrozole44 50 60 1112.6CYP19A1, SHBG
24levonorgestrel44 60 28 1112.6CYP19A1, SHBG
2517-hydroxyprogesterone44 2410.6CYP19A1, SHBG
26flutamide44 60 1111.6CYP19A1, SHBG
27estrone sulfate44 2410.6CYP19A1, SHBG
2825-hydroxyvitamin d449.6CYP19A1, SHBG
2917beta-hydroxysteroid449.6HSD17B3, CYP19A1
30diethylstilbestrol44 28 1111.6CYP19A1, SHBG
313beta-hydroxysteroid449.5CYP19A1, INHA
32ketoconazole44 28 24 1112.5SHBG, CYP19A1
33dehydroepiandrosterone sulfate449.5SHBG, CYP19A1
34biotin44 24 1111.4SRY, SHBG, INHA
35progestins449.4CYP19A1, SHBG
36estrone44 28 24 1112.3HSD17B3, CYP19A1, SHBG
37raloxifene44 50 28 1112.3CYP19A1, SHBG
38progestin449.3SHBG, CYP19A1
39metformin44 50 1111.2SHBG, CYP19A1
40gnrh449.2CYP19A1, INHA, SHBG
41agarose449.1SRY, APOD, INHA
42dhea449.0CYP19A1, SHBG
43androstenedione44 249.9SHBG, CYP19A1, INHA, HSD17B3
44tamoxifen44 50 28 1111.8SHBG, CYP19A1, APOD
45dihydrotestosterone44 28 24 1111.5CYP19A1, SHBG, APOD, SRY
46progesterone44 28 60 24 1112.4SHBG, CYP19A1, INHA, APOD
47estradiol44 24 1110.4INHA, SHBG, HSD17B3, SRY, CYP19A1
48estrogen448.0CYP19A1, HSD17B3, SHBG, INHA, APOD
49steroid448.0INHA, CYP19A1, SRY, APOD, SHBG
50testosterone44 60 24 1110.6HSD17B3, CYP19A1, INHA, SHBG, SRY, APOD

GO Terms for genes affiliated with Gynecomastia

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Biological processes related to Gynecomastia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1steroid metabolic processGO:00082029.4HSD17B3, CYP19A1

Sources for Gynecomastia

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet