MCID: GYN001
MIFTS: 46

Gynecomastia malady

Endocrine diseases, Reproductive diseases categories
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Summaries for Gynecomastia

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65Wikipedia, 33MalaCards
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Wikipedia:65 Gynecomastia /??a?n?k??m more...

MalaCards: Gynecomastia, also known as gynaecomastia, is related to leydig cell tumor and pseudohermaphroditism. An important gene associated with Gynecomastia is HSD17B3 (hydroxysteroid (17-beta) dehydrogenase 3), and among its related pathways are Androgen Signaling and Steroid hormone biosynthesis. The drugs tamoxifen and tamoxifen citrate and the compounds Androst-5-ene-3b,17b-diol and vorozole have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and skin.

Aliases & Classifications for Gynecomastia

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 35MeSH, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases, Reproductive diseases


Aliases & Descriptions:

gynecomastia 8 10 45 62
gynaecomastia 8


External Ids:

Disease Ontology8 DOID:12698
MeSH35 D006177
NCIt40 C3073

Related Diseases for Gynecomastia

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17GeneCards, 18GeneDecks
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Diseases related to Gynecomastia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 171)
idRelated DiseaseScoreTop Affiliating Genes
1leydig cell tumor30.6INHA, CYP19A1
2pseudohermaphroditism30.5CYP19A1, HSD17B3, SRY
3peutz-jeghers syndrome30.5CYP19A1, INHA
4breast cancer30.4APOD, SHBG, CYP19A1
5hypogonadism30.4CYP19A1, SHBG
6prostate cancer30.4CYP19A1, INHA, SHBG, HSD17B3, APOD, SRY
7sertoli cell tumor30.3INHA, CYP19A1
8hypospadias30.1HSD17B3, SRY
9partial androgen insensitivity syndrome30.1CYP19A1, SHBG
10testicular cancer30.0SHBG, INHA
11androgen insensitivity syndrome30.0SHBG, HSD17B3, SRY
12cryptorchidism30.0SRY, SHBG, CYP19A1
13short stature30.0SRY, SHBG, CYP19A1
14congenital adrenal hyperplasia30.0SRY, CYP19A1
15hermaphroditism29.9SRY
16precocious puberty29.8SHBG, CYP19A1
17adrenal adenoma29.8INHA, CYP19A1
18breast cyst29.8APOD, CYP19A1
19klinefelter's syndrome29.8CYP19A1, INHA, SHBG
20osteoporosis29.8SHBG, CYP19A1
21prostatitis10.5
22ductal carcinoma in situ10.3
23obesity10.2
24arthritis10.2
25rheumatoid arthritis10.2
26aromatase excess syndrome10.2
27male breast cancer10.2
28hepatocellular carcinoma10.2
29leukemia10.2
3017-beta hydroxysteroid dehydrogenase 3 deficiency10.2
31hypoactive sexual desire disorder10.1SHBG
32neurofibromatosis10.1
33kennedy's disease10.1
34infant gynecomastia10.1
35hyperprolactinemia10.1
36adenoma10.1
37myeloid leukemia10.1
38mental retardation gynecomastia obesity x-linked10.1
39ovarian disease10.1CYP19A1
40dysgerminoma10.0INHA, SRY
41amenorrhea10.0SHBG, SRY
42turner syndrome10.0SRY, SHBG
43premature ovarian failure10.0INHA, SHBG
44hypogonadism, hypergonadotropic10.0CYP19A1, SHBG
45complete androgen insensitivity syndrome10.0CYP19A1, SHBG
46androgenic alopecia10.0SHBG, CYP19A1
47endometrial stromal sarcoma10.0CYP19A1, INHA
48anovulation10.0CYP19A1, SHBG
49aorta atresia10.0CYP19A1, INHA
50abrikosov's tumor10.0CYP19A1, INHA

Graphical network of the top 20 diseases related to Gynecomastia:



Diseases related to gynecomastia

Symptoms for Gynecomastia

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Drugs & Therapeutics for Gynecomastia

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Gynecomastia

Search NIH Clinical Center for Gynecomastia

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Gynecomastia

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Anatomical Context for Gynecomastia

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33MalaCards
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MalaCards organs/tissues related to Gynecomastia:

33
Breast, Prostate, Skin, Lung, Testis, Myeloid, Spinal cord, Liver, Heart, Thyroid, Pituitary

Animal Models for Gynecomastia or affiliated genes

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Publications for Gynecomastia

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52PubMed
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Articles related to Gynecomastia:

(show top 50)    (show all 522)
idTitleAuthorsYear
1
Commentary on "gynecomastia: etiologies, clinical presentations, diagnosis, and management". (24389787)
2014
2
An Aroma of Complexity: How the Unique Genetics of Aromatase (CYP19A1) Explain Diverse Phenotypes From Hens and Hyenas to Human Gynecomastia, and Testicular and Other Tumors. (24311795)
2013
3
Prepubertal gynecomastia in two monozygotic twins with Peutz-Jeghers syndrome: clinical and surgical management. (23968963)
2013
4
18F-FDG PET/CT in detection of gynecomastia in patients with hepatocellular carcinoma. (23809917)
2013
5
A randomized trial comparing tamoxifen therapy vs. tamoxifen prophylaxis in bicalutamide-induced gynecomastia. (22502790)
2012
6
SRY-positive 46, XY male with vanishing testis syndrome, feminization and gynecomastia. (23441485)
2012
7
Euprolactinemic gynecomastia and galactorrhea with risperidone-fluvoxamine combination. (22506441)
2011
8
Unilateral gynecomastia in a young adult. (21673478)
2011
9
Gynecomastia - a difficult diagnostic problem. (21528484)
2011
10
Fibromatosis of the male breast with concurrent florid-type gynecomastia: Report of a case and review of literature. (21511401)
2011
11
Prepubertal gynecomastia in two monozygotic twins with Peutz-Jeghers syndrome: two years' treatment with anastrozole and genetic study. (21335955)
2011
12
Treatment of adolescent gynecomastia. (20223338)
2010
13
High grade gynecomastia: surgical correction and potential impact on erectile function. (20233285)
2010
14
Gynecomastia, obesity and underdeveloped testis and penis: suspected hypophysitis successfully cured with low dose of cyclosporine A. (19951616)
2009
15
It is reasonable to do endocrine investigation in gynecomastia. (18216522)
2008
16
Leydig cell hyperplasia revealed by gynecomastia. (18660859)
2008
17
Phenotype of patients with gynecomastia]. (18465688)
2008
18
Testicular interstitial cell tumor and gynecomastia in a rabbit. (17606513)
2007
19
Childhood gynecomastia: a clinical analysis of 240 cases. (17937844)
2007
20
Clonidine-induced gynecomastia and hyperprolactinemia in a 6-year-old child. (16401171)
2005
21
Gynecomastia and mucosal lentigines in an 8-year-old boy. (16198789)
2005
22
Sertoli cell tumor causing prepubertal gynecomastia in a boy with peutz-jeghers syndrome: the outcome of 1-year treatment with the aromatase inhibitor testolactone. (15947469)
2005
23
Possible involvement of aromatase overexpression induced by cyclo-oxygenase-2 in the pathogenesis of idiopathic gynecomastia. (16392624)
2005
24
A case-control study of gynecomastia in HIV-1-infected patients receiving HAART. (14959701)
2004
25
Sonography of pediatric male breast masses: gynecomastia and beyond. (15378216)
2004
26
Psychosocial adjustment of two boys with gynecomastia. (15151602)
2004
27
Gynecomastia following chemotherapy for testicular cancer. (12660472)
2003
28
Expression of BRCA1 and BRCA2 in male breast cancers and gynecomastias. (12680164)
2003
29
Gynecomastia in male HIV patients MRI and US findings. (12213363)
2002
30
Gynecomastia: complications of the subcutaneous mastectomy. (11842972)
2002
31
Occult Leydig cell tumor in a patient with gynecomastia. (11497478)
2001
32
Isolated relapse of acute lymphoblastic leukemia in the breast masquerading as gynecomastia. (10896624)
2000
33
Treatment of adolescent gynecomastia using a bipedicle technique. (9523606)
1998
34
Gynecomastia following spinal cord disorder. (9161376)
1997
35
Evaluation and treatment of gynecomastia. (9105209)
1997
36
Gynecomastia with metoclopramide use in pediatric patients. (9077721)
1997
37
Report of an XX male with hypospadias and pubertal gynecomastia, SRY gene negative in blood leukocytes but SRY gene positive in testicular cells. (9030973)
1997
38
Prepubertal gynecomastia during growth hormone therapy. (7699552)
1995
39
Case report: finasteride-induced gynecomastia in a 62-year-old man. (7539584)
1995
40
Correction of gynecomastia with an inframammary incision and subsequent scar. (7480316)
1995
41
Nipple placement in simple mastectomy with free nipple grafting for severe gynecomastia. (7972427)
1994
42
Medications that cause gynecomastia. (8248425)
1993
43
Metastatic hepatocellular carcinoma of the breast, simulating gynecomastia: diagnosis by fine-needle aspiration biopsy. (1334827)
1992
44
Infantile gynecomastia with bloody nipple discharge. (1552426)
1992
45
Mineralocorticoids in the mechanism of gynecomastia in adrenal hyperplasia caused by 11 beta-hydroxylase deficiency. (1993958)
1991
46
Re: Liposuction of giant lipoma and the treatment of gynecomastia without sharp excision. (2029145)
1991
47
Hormonal studies and physical maturation in adolescent gynecomastia. (2137877)
1990
48
The occurrence of gynecomastia upon withdrawal of clomiphene citrate treatment for idiopathic oligospermia. (6773824)
1980
49
Leydig-cell tumor of the testis with gynecomastia and elevated estrogen levels. (868795)
1977
50
Mediastinal seminoma. Associated with exophthalmos and gynecomastia. (4819703)
1974

Variations for Gynecomastia

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Expression for genes affiliated with Gynecomastia

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gynecomastia

Search GEO for disease gene expression data for Gynecomastia.

Pathways for genes affiliated with Gynecomastia

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50PathCards, 53QIAGEN, 30KEGG, 38NCBI BioSystems Database, 55Reactome, 60Thomson Reuters
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Pathways related to Gynecomastia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5SRY, SHBG
2
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism38
9.4HSD17B3, CYP19A1
3
Show member pathways
9.4HSD17B3, CYP19A1
4
Show member pathways
Estrogen biosynthesis60
Androstenedione and testosterone biosynthesis and metabolism p.160
9.4HSD17B3, CYP19A1
5
Show member pathways
estradiol biosynthesis II38
androgen biosynthesis38
estradiol biosynthesis I38
progesterone biosynthesis38
9.4HSD17B3, CYP19A1
69.3CYP19A1, INHA

Compounds for genes affiliated with Gynecomastia

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24HMDB, 45Novoseek, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 51PharmGKB
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Compounds related to Gynecomastia according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1Androst-5-ene-3b,17b-diol249.9HSD17B3, CYP19A1
2vorozole459.8SHBG, CYP19A1
3formestane459.8CYP19A1, SHBG
4ment459.8CYP19A1, SHBG
5atrazine459.8SHBG, CYP19A1
6androstenediol459.7SHBG, CYP19A1
7carbimazole45 1110.7SHBG, CYP19A1
8nandrolone45 2410.7SHBG, CYP19A1
9goserelin45 29 1111.7SHBG, CYP19A1
10megestrol acetate459.7CYP19A1, SHBG
115alpha-androstane-3alpha,17beta-diol459.7CYP19A1, SHBG
12leuprolide acetate459.7SHBG, CYP19A1
13finasteride45 61 24 1112.7CYP19A1, SHBG
14exemestane45 51 61 1112.7SHBG, CYP19A1
15anastrozole45 51 1111.7SHBG, CYP19A1
16toremifene45 1110.7CYP19A1, SHBG
17naringenin45 1110.7CYP19A1, SHBG
18Testosterone sulfate249.7CYP19A1, HSD17B3
19clomiphene citrate459.7CYP19A1, SHBG
20tibolone459.7SHBG, CYP19A1
21danazol45 24 1111.7SHBG, CYP19A1
22cyproteroneacetate459.7SHBG, CYP19A1
23letrozole45 51 61 1112.6SHBG, CYP19A1
24levonorgestrel45 61 29 1112.6CYP19A1, SHBG
2517-hydroxyprogesterone45 2410.6SHBG, CYP19A1
26flutamide45 61 1111.6SHBG, CYP19A1
27estrone sulfate45 2410.6CYP19A1, SHBG
2825-hydroxyvitamin d459.6SHBG, CYP19A1
2917beta-hydroxysteroid459.6CYP19A1, HSD17B3
30diethylstilbestrol45 29 1111.6SHBG, CYP19A1
313beta-hydroxysteroid459.5INHA, CYP19A1
32ketoconazole45 29 24 1112.5CYP19A1, SHBG
33dehydroepiandrosterone sulfate459.5CYP19A1, SHBG
34biotin45 24 1111.4INHA, SHBG, SRY
35progestins459.4SHBG, CYP19A1
36estrone45 29 24 1112.3HSD17B3, SHBG, CYP19A1
37raloxifene45 51 29 1112.3CYP19A1, SHBG
38progestin459.3SHBG, CYP19A1
39metformin45 51 1111.2SHBG, CYP19A1
40gnrh459.2SHBG, INHA, CYP19A1
41agarose459.1INHA, APOD, SRY
42dhea459.0SHBG, CYP19A1
43androstenedione45 249.9CYP19A1, INHA, SHBG, HSD17B3
44tamoxifen45 51 29 1111.8CYP19A1, SHBG, APOD
45dihydrotestosterone45 29 24 1111.5CYP19A1, SHBG, APOD, SRY
46progesterone45 29 61 24 1112.4CYP19A1, INHA, SHBG, APOD
47estradiol45 24 1110.4SRY, HSD17B3, SHBG, INHA, CYP19A1
48estrogen458.0CYP19A1, INHA, SHBG, HSD17B3, APOD
49steroid458.0SRY, APOD, SHBG, INHA, CYP19A1
50testosterone45 61 24 1110.6SRY, APOD, HSD17B3, SHBG, INHA, CYP19A1

GO Terms for genes affiliated with Gynecomastia

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16Gene Ontology
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Biological processes related to Gynecomastia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid metabolic processGO:0082029.4HSD17B3, CYP19A1

Products for genes affiliated with Gynecomastia

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Sources for Gynecomastia

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet