Aliases & Classifications for Gynecomastia

MalaCards integrated aliases for Gynecomastia:

Name: Gynecomastia 12 72 28 51 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:12698
ICD10 32 N62
MeSH 41 D006177
NCIt 46 C3073
UMLS 69 C0018418

Summaries for Gynecomastia

MalaCards based summary : Gynecomastia is related to aromatase excess syndrome and androgen insensitivity, partial. An important gene associated with Gynecomastia is HSD17B3 (Hydroxysteroid 17-Beta Dehydrogenase 3), and among its related pathways/superpathways are Integrated Breast Cancer Pathway and Signaling by ERBB4. The drugs Bicalutamide and Androgen Antagonists have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and liver, and related phenotypes are endocrine/exocrine gland and integument

Wikipedia : 72 Gynecomastia is an endocrine system disorder in which there is a non-cancerous increase in the size of... more...

Related Diseases for Gynecomastia

Diseases related to Gynecomastia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 281)
# Related Disease Score Top Affiliating Genes
1 aromatase excess syndrome 33.5 CYP19A1 POMC
2 androgen insensitivity, partial 31.6 AR CYP19A1 SHBG
3 androgen insensitivity syndrome 30.7 AR CGA SHBG SRY
4 pseudohermaphroditism 30.6 AR CYP19A1 HSD17B3
5 leydig cell tumor 30.4 CYP19A1 ESR1
6 ductal carcinoma in situ 30.0 AR CYP19A1 ESR1 PGR
7 vaginitis 29.9 AR ESR1
8 hypospadias 29.8 AR HSD17B3 SRY
9 bilateral breast cancer 29.7 ESR1 PGR
10 leiomyoma 29.5 CYP19A1 ESR1 PGR
11 impotence 29.5 KLK3 PRL SHBG
12 infertility 29.5 CYP19A1 PGR PRL
13 sexual disorder 29.3 KLK3 PRL SHBG
14 hermaphroditism 29.2 AR SHBG SRY
15 testicular cancer 29.1 AR CGA SHBG
16 varicocele 29.0 CGA PRL SHBG
17 osteoporosis 28.9 AR CYP19A1 ESR1 SHBG
18 hyperthyroidism 28.8 CGA PRL SHBG
19 breast disease 28.4 ESR1 KLK3 PGR PRL SHBG
20 cryptorchidism, unilateral or bilateral 28.2 AR CGA CYP19A1 SHBG SRY
21 infant gynecomastia 12.2
22 wilson-turner x-linked mental retardation syndrome 11.8
23 17-beta hydroxysteroid dehydrogenase iii deficiency 11.7
24 spinal and bulbar muscular atrophy, x-linked 1 11.2
25 testicular seminoma 11.2
26 mental retardation-hypotonic facies syndrome, x-linked, 1 10.9
27 borjeson-forssman-lehmann syndrome 10.8
28 46,xx sex reversal 1 10.8
29 alopecia, neurologic defects, and endocrinopathy syndrome 10.8
30 hypogonadotropic hypogonadism 10.8
31 49, xxxyy syndrome 10.8
32 transsexualism 10.5 AR CYP19A1
33 nodular prostate 10.4 AR KLK3
34 prostatic acinar adenocarcinoma 10.4 AR KLK3
35 benign metastasizing leiomyoma 10.4 CYP19A1 PGR
36 corneal abscess 10.4 AR PGR
37 intracystic papillary adenoma 10.4 PGR PRL
38 endometrial disease 10.4 CYP19A1 ESR1
39 vulvar syringoma 10.4 ESR1 PGR
40 vestibular gland benign neoplasm 10.4 ESR1 PGR
41 lung leiomyoma 10.4 ESR1 PGR
42 bartholin's gland adenoma 10.4 ESR1 PGR
43 glassy cell carcinoma of the cervix 10.4 ESR1 PGR
44 vulvar benign neoplasm 10.4 ESR1 PGR
45 trigonitis 10.4 ESR1 PGR
46 vulvar leiomyoma 10.4 ESR1 PGR
47 estrogen resistance 10.4 CYP19A1 ESR1
48 predominantly cortical thymoma 10.3 ESR1 PGR
49 papillary hidradenoma 10.3 AR PGR
50 aromatase deficiency 10.3 CYP19A1 ESR1

Graphical network of the top 20 diseases related to Gynecomastia:



Diseases related to Gynecomastia

Symptoms & Phenotypes for Gynecomastia

MGI Mouse Phenotypes related to Gynecomastia:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.7 POMC PRL AR CGA CYP19A1 ESR1
2 integument MP:0010771 9.43 POMC PRL AR CYP19A1 ESR1 PGR
3 neoplasm MP:0002006 9.02 POMC PRL AR ESR1 PGR

Drugs & Therapeutics for Gynecomastia

Drugs for Gynecomastia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bicalutamide Approved Phase 4,Phase 3,Phase 2 90357-06-5 2375 56069
2 Androgen Antagonists Phase 4,Phase 3,Phase 2
3 Androgens Phase 4,Phase 3,Phase 2
4 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
5 Hormones Phase 4,Phase 3,Phase 2,Phase 1
6 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
7
Tamoxifen Approved Phase 3,Phase 2 10540-29-1 2733526
8
Anastrozole Approved, Investigational Phase 3,Phase 2 120511-73-1 2187
9 Antineoplastic Agents, Hormonal Phase 3,Phase 2
10 Estrogen Antagonists Phase 3,Phase 2
11 Estrogens Phase 3,Phase 2
12 Steroid Synthesis Inhibitors Phase 3,Phase 2
13 Bone Density Conservation Agents Phase 3,Phase 2
14 Estrogen Receptor Modulators Phase 3,Phase 2
15 Selective Estrogen Receptor Modulators Phase 3,Phase 2
16 Aromatase Inhibitors Phase 3,Phase 2
17
Dutasteride Approved, Investigational Phase 2 164656-23-9 6918296 152945
18
Spironolactone Approved Phase 2,Phase 1 1952-01-7, 52-01-7 5833
19
Testolactone Approved, Investigational Phase 2 968-93-4 13769
20
Testosterone Approved, Investigational Phase 2 58-22-0 6013
21 5-alpha Reductase Inhibitors Phase 2
22 Deslorelin Phase 2
23 diuretics Phase 2,Phase 1
24 Diuretics, Potassium Sparing Phase 2,Phase 1
25 Mineralocorticoid Receptor Antagonists Phase 2,Phase 1
26 Mineralocorticoids Phase 2,Phase 1
27 Natriuretic Agents Phase 2,Phase 1
28 Antipsychotic Agents
29 Central Nervous System Depressants
30 Psychotropic Drugs
31 Quetiapine Fumarate 111974-72-2
32 Tranquilizing Agents

Interventional clinical trials:

(show all 15)

# Name Status NCT ID Phase Drugs
1 Compare the Value of Prophylactic Versus Therapeutic Breast Radiotherapy in CASODEX Completed NCT00590213 Phase 4 Casodex 150mg
2 Gynecomastia Extension Study Completed NCT00637182 Phase 3 Anastrozole
3 Two Different Regimens of Nolvadex in Preventing Gynecomastia Induced by Casodex 150 mg in Patients With Prostate Cancer Completed NCT00233610 Phase 3 Bicalutamide;Tamoxifen
4 Efficacy and Toxicity of Bicalutamide and Dutasteride vs. Standard Care for Prostate Cytoreduction for Brachytherapy Unknown status NCT00866554 Phase 2 administration of a LHRH agonist and Bicalutamide;administration of Bicalutamide, Dutasteride and Tamoxifen
5 Open Label Arimidex in Gynecomastia Completed NCT00241436 Phase 2 Anastrozole (ARIMIDEX™)
6 Casodex - Nolvadex Combination Completed NCT00637871 Phase 2 Casodex;Tamoxifen
7 Treatment of Boys With Precocious Puberty Completed NCT00001202 Phase 2 Spironolactone;Testolactone;Deslorelin
8 Spironolactone for Pulmonary Arterial Hypertension Recruiting NCT01712620 Phase 1, Phase 2 Spironolactone;Placebo
9 Eplerenone Versus Spironolactone as Treatment of Ascites Due to Liver Cirrhosis; a Study of Efficacy and Side Effects Withdrawn NCT01801228 Phase 2 Eplerenone
10 Targeted Fat Reduction of Pseudogynecomastia in the Male Breast Using the ZELTIQ Coolsculpting System Unknown status NCT01791660
11 Post-massive Weight Loss Chest Contouring: Inferior Pedicle Technique in Pseudo-gynecomastia Correction Completed NCT03319862
12 Changes in Hyperprolactinemia Secondary to Antipsychotics After Switching to Quetiapine Completed NCT00952757
13 Sperm Production in Kleinfelter Syndrome Patients After Mesenchymal Stem Cell Injection Completed NCT02414295 Mesenchymal stem cell injection
14 Adaptation Among Adolescents and Adults With Klinefelter Syndrome Completed NCT00896272
15 UltraShape Device for Non-Invasive Fat Reduction in the Male Breast (Pseudogynecomastia) Recruiting NCT02711605

Search NIH Clinical Center for Gynecomastia

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Gynecomastia

Genetic tests related to Gynecomastia:

# Genetic test Affiliating Genes
1 Gynecomastia 28

Anatomical Context for Gynecomastia

MalaCards organs/tissues related to Gynecomastia:

38
Breast, Prostate, Liver, Skin, Bone, Lung, Testis

Publications for Gynecomastia

Articles related to Gynecomastia:

(show top 50) (show all 661)
# Title Authors Year
1
Comment to: "Complications and Outcomes After Gynecomastia Surgery: Analysis of 204 Pediatric and 1583 Adult Cases from a National Multi-center Database". ( 29075818 )
2018
2
Re: Gynecomastia Surgery-Impact on Life Quality: A Prospective Case-Control Study. ( 29319581 )
2018
3
Closed-Suction Drains After Subcutaneous Mastectomy for Gynecomastia: Do they Reduce Complications? ( 29302730 )
2018
4
Changing practices: The addition of a novel surgical approach to gynecomastia. ( 29395029 )
2018
5
Quantitative CT Assessment of Gynecomastia in the General Population and in Dialysis, Cirrhotic, and Obese Patients. ( 29326049 )
2018
6
Efficiency of Imaging Modalities in Male Breast Disease: Can Ultrasound Give Additional Information for Assessment of Gynecomastia Evolution? ( 29322116 )
2018
7
Comment to: "Complications and Outcomes After Gynecomastia Surgery: Analysis of 204 Pediatric and 1583 Adult Cases from a National Multi-center Database". ( 29075817 )
2018
8
Adrenocortical carcinoma characterized by gynecomastia: A case report. ( 29403152 )
2018
9
Discussion on "Gynecomastia Surgery-Impact on Life Quality: A prospective Case-Control Study". ( 29319580 )
2018
10
A boy with 46,X,+mar presenting gynecomastia and short stature. ( 29301188 )
2017
11
The burden of gynecomastia among men on antiretroviral therapy in Zomba, Malawi. ( 29155891 )
2017
12
Gynecomastia: histological appearance in different age groups. ( 28876176 )
2017
13
Closed-Suction Drains After Subcutaneous Mastectomy for Gynecomastia: Do They Reduce Complications? ( 28842781 )
2017
14
Low zinc levels may contribute to gynecomastia in puberty. ( 28965587 )
2017
15
Lymphomatous Involvement of Male Breast in a Patient with Bilateral Gynecomastia: Demonstration with (18)F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography. ( 28680222 )
2017
16
Pubertal gynecomastia: years of progress - the Hacettepe experience. ( 28598804 )
2017
17
Adolescent Gynecomastia. ( 28613047 )
2017
18
Feminizing Adrenocortical Carcinoma Without Gynecomastia. ( 28804590 )
2017
19
Reply: Gynecomastia Classification for Surgical Management: A Systematic Review and Novel Classification System. ( 28617743 )
2017
20
False Positive Uptake in Bilateral Gynecomastia on 68Ga-PSMA PET/CT Scan. ( 28682848 )
2017
21
The circumareolar approach to gynecomastia and transgender surgery: modifications to provide correct nipple areolar complex position and shape. ( 28876553 )
2017
22
Gynecomastia: glandular-liposculpture through a single transaxillary one hole incision. ( 28758536 )
2017
23
Peutz-Jeghers syndrome with early onset of pre-adolescent gynecomastia: a predigree case report and clinical and molecular genetic analysis. ( 28560011 )
2017
24
Orange Peel Excision of Gland: A Novel Surgical Technique for Treatment of Gynecomastia. ( 28795986 )
2017
25
Management of Gynecomastia in Patients With Different Body Types: Considerations on 312 Consecutive Treated Cases. ( 28697007 )
2017
26
Reply to the Comment on: Management of Gynecomastia in Patients With Different Body Types: Considerations on 312 Consecutive Treated Cases. ( 28697008 )
2017
27
Discussion: The Characteristics and Short-Term Surgical Outcomes of Adolescent Gynecomastia by B.S. Choi et al. ( 28639067 )
2017
28
Gynecomastia Classification for Surgical Management: A Systematic Review and Novel Classification System. ( 28617739 )
2017
29
Closed-Suction Drains After Subcutaneous Mastectomy for Gynecomastia: Do They Reduce Complications? A Different Approach. ( 29264682 )
2017
30
Management of Adolescent Gynecomastia: An Update. ( 28845839 )
2017
31
Gynecomastia ( 28613563 )
2017
32
Multiple symmetric lipomatosis and gynecomastia: A case report and relative literature review. ( 28438575 )
2017
33
Sexual function and hormone profile in young adult men with idiopathic gynecomastia: Comparison with healthy controls. ( 27177337 )
2016
34
Gynecomastia With Atypical Ductal Hyperplasia and Ductal Carcinoma In Situ Associated With Invasive Breast Carcinoma in a Male Patient on Antiretroviral Therapy: A Case Report. ( 26612847 )
2016
35
Evaluation of Serum Vitamin D Levels in Adolescents with Pubertal Gynecomastia. ( 27920626 )
2016
36
Incidental unilateral and bilateral ductal carcinoma in situ encountered in the surgical management of young male gynecomastia. ( 27612041 )
2016
37
A CASE OF AN AROMATASE-PRODUCING SERTOLI CELL TUMOR PRESENTING WITH GYNECOMASTIA. ( 28442671 )
2016
38
A Novel Mutation In Human Androgen Receptor Gene Causing Partial Androgen Insensitivity Syndrome In A Patient Presenting With Gynecomastia At Puberty. ( 27087292 )
2016
39
Combined approach for gynecomastia. ( 26955509 )
2016
40
The Satisfaction Rate among Patients and Surgeons after Periareolar Surgical Approach to Gynecomastia along with Liposuction. ( 27853693 )
2016
41
Endocrine and molecular investigations in a cohort of 25 adolescent males with prominent/persistent pubertal gynecomastia. ( 26845730 )
2016
42
Intratubular large cell hyalinizing Sertoli cell tumor of the testis presenting with prepubertal gynecomastia: a case report. ( 27488929 )
2016
43
Anatomy of the Gynecomastia Tissue and Its Clinical Significance. ( 27622122 )
2016
44
Who Gets Severe Gynecomastia Among HIV-Infected Children In The UK And Ireland? ( 27879556 )
2016
45
Association between plasma kisspeptin levels and adolescent gynecomastia. ( 27502882 )
2016
46
Gynecomastia and hormones. ( 27145756 )
2016
47
Gynecomastia Surgery-Impact on Life Quality: A Prospective Case-Control Study. ( 27404477 )
2016
48
Management of Gynecomastia in Patients With Different Body Types: Considerations on 312 Consecutive Treated Cases. ( 27805927 )
2016
49
Gynecomastia in the Ancient Egypt limestone statue of Hemiunu, the architect of the Great Pyramid of Giza (fl. 2570 BC). ( 27761884 )
2016
50
Multiple Schwannomas in a Patient with Gynecomastia. ( 27988983 )
2016

Variations for Gynecomastia

Expression for Gynecomastia

Search GEO for disease gene expression data for Gynecomastia.

Pathways for Gynecomastia

GO Terms for Gynecomastia

Biological processes related to Gynecomastia according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.91 AR CGA ESR1 PGR POMC
2 regulation of transcription by RNA polymerase II GO:0006357 9.83 AR CGA ESR1 SRY
3 transcription initiation from RNA polymerase II promoter GO:0006367 9.67 AR ESR1 PGR
4 cell-cell signaling GO:0007267 9.62 AR CGA PGR POMC
5 mammary gland development GO:0030879 9.54 CYP19A1 PGR
6 sex differentiation GO:0007548 9.48 AR SRY
7 peptide hormone processing GO:0016486 9.46 CGA POMC
8 mammary gland alveolus development GO:0060749 9.43 AR ESR1
9 androgen metabolic process GO:0008209 9.4 CYP19A1 ESR1
10 uterus development GO:0060065 9.37 CYP19A1 ESR1
11 prostate gland growth GO:0060736 9.26 AR CYP19A1
12 testosterone biosynthetic process GO:0061370 9.16 CYP19A1 HSD17B3
13 steroid hormone mediated signaling pathway GO:0043401 9.13 AR ESR1 PGR
14 tertiary branching involved in mammary gland duct morphogenesis GO:0060748 8.62 AR PGR

Molecular functions related to Gynecomastia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.73 AR ESR1 PGR PHF6
2 lipid binding GO:0008289 9.67 AR ESR1 PGR SHBG
3 hormone activity GO:0005179 9.58 CGA POMC PRL
4 ATPase binding GO:0051117 9.5 AR ESR1 PGR
5 steroid hormone receptor activity GO:0003707 9.43 AR ESR1 PGR
6 androgen binding GO:0005497 9.16 AR SHBG
7 nuclear receptor activity GO:0004879 9.13 AR ESR1 PGR
8 steroid binding GO:0005496 8.92 AR ESR1 PGR SHBG

Sources for Gynecomastia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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