MCID: GYN001
MIFTS: 57

Gynecomastia malady

Summaries for Gynecomastia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Gynecomastia /ˌɡaɪnɨkɵˈmæstiə/ is the benign enlargement of breast tissue in males.[a] It may... more...

MalaCards: Gynecomastia, also known as gynaecomastia, is related to prostatitis and breast cancer. An important gene associated with Gynecomastia is HSD17B3 (hydroxysteroid (17-beta) dehydrogenase 3), and among its related pathways are estrogen biosynthesis and Estrogen biosynthesis. The drugs tamoxifen and tamoxifen citrate and the compounds estrogen and goserelin have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and skin, and related mouse phenotypes are endocrine/exocrine gland and integument.

Aliases & Classifications for Gynecomastia

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

gynecomastia 8 10 44 60
gynaecomastia 8


External Ids:

Disease Ontology8 DOID:12698
MeSH34 D006177
NCIt39 C3073

Related Diseases for Gynecomastia

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17GeneCards, 18GeneDecks
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Diseases related to Gynecomastia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 258)
idRelated DiseaseScoreTop Affiliating Genes
1prostatitis30.6SRD5A1, KLK3
2breast cancer30.6BRCA2, BRCA1
3prostate cancer30.6SRD5A1, KLK3
4leydig cell tumor30.4SRD5A1, INHA, CYP17A1, CYP19A1, CGB5, CGA
5pseudohermaphroditism30.4SRD5A2, SRY, CYP17A1, CYP19A1, HSD17B3
6peutz-jeghers syndrome30.4INHA, CYP19A1, BRCA2
7ductal carcinoma in situ30.3ESR1, PGR, BRCA2, BRCA1
8hypogonadism30.3CYP19A1, SHBG, PRL, CGB5, CGA, GNRH1
9obesity30.3SRD5A1, INHA, NR3C2, SHBG
10male breast cancer30.3ESR1, PGR, APOD, BRCA2, BRCA1
11sertoli cell tumor30.1PGR, INHA, CYP19A1
12leukemia30.1NR3C2, BRCA2, BRCA1
13hepatocellular carcinoma30.1SRD5A2, CYP17A1, SHBG, APOD, BRCA2
14aromatase excess syndrome30.1CYP19A1
15hyperprolactinemia30.0SRD5A1, SHBG, PRL, CGB5, CGA, GNRH1
16adenoma30.0SRD5A1, INHA, CYP17A1, NR3C2, SHBG, PRL
17partial androgen insensitivity syndrome29.9SRD5A1, CYP19A1, SHBG
18seminoma29.9INHA, CGB5, CGA
19testicular cancer29.9INHA, SHBG, CGB5, CGA
20varicocele29.9SHBG, PRL, CGA, GNRH1
21impotence29.9SRD5A1, SHBG, PRL, KLK3
22hypothyroidism29.9SHBG, PRL, CGA, GNRH1
23prolactinoma29.9ESR1, PRL, CGA, GNRH1
24bilateral breast cancer29.9ESR1, PGR, BRCA2, BRCA1
25androgen insensitivity syndrome29.9SRD5A2, SRD5A1, SRY, SHBG, CGA, HSD17B3
26hypospadias29.9SRD5A2, SRD5A1, SRY, CYP17A1, CGA, HSD17B3
27graves' disease29.9SHBG, CGA
28cryptorchidism29.9SRD5A1, SRY, CYP19A1, SHBG, CGB5, CGA
29adenocarcinoma29.9ESR1, SRD5A1, PGR, INHA, CGB5, BRCA2
30hermaphroditism29.7SRY
31thyroiditis29.7CGA
32aromatase deficiency29.7CYP19A1
33hypertension29.7CYP17A1, NR3C2
34sarcoma29.7CGB5, BRCA2
35breast fibroadenoma29.7ESR1, PGR
36adrenal adenoma29.7INHA, CYP17A1, CYP19A1
37breast cyst29.7CYP19A1, CGB5, APOD, KLK3
38sexual disorder29.7SHBG, PRL, GNRH1, KLK3
39pituitary adenoma29.7INHA, PRL, CGA, GNRH1
40congenital adrenal hyperplasia29.7SRD5A1, SRY, CYP17A1, CYP19A1, GNRH1
41oligospermia29.7SRD5A1, PRL, CGB5, CGA, GNRH1
42hyperthyroidism29.7SRD5A1, SHBG, PRL, CGB5, CGA
43leiomyoma29.7ESR1, PGR, CYP17A1, CYP19A1, GNRH1
44transitional cell carcinoma29.7SRD5A1, CGB5, KLK3
45klinefelter's syndrome29.7SRD5A1, INHA, CYP19A1, SHBG, PRL, CGA
46in situ carcinoma10.2
47infant gynecomastia10.2
48arthritis10.2
49rheumatoid arthritis10.2
50x-linked spinal-bulbar muscle atrophy10.2

Graphical network of the top 20 diseases related to Gynecomastia:



Diseases related to gynecomastia

Clinical Features for Gynecomastia

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Drugs & Therapeutics for Gynecomastia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Gynecomastia

Drug clinical trials:

Search ClinicalTrials for Gynecomastia

Search NIH Clinical Center for Gynecomastia

Search CenterWatch for Gynecomastia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Gynecomastia

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Anatomical Context for Gynecomastia

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32MalaCards
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MalaCards organs/tissues related to Gynecomastia:

32
Breast, Prostate, Skin, Lung, Testis, Spinal cord, Liver, Myeloid, Heart, Pituitary, Thyroid

Animal Models for Gynecomastia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gynecomastia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.8BRCA1, BRCA2, INHA, SRY, SRD5A1, SRD5A2
2MP:00107719.8BRCA1, BRCA2, GNRH1
3MP:00020069.6BRCA1, BRCA2, GNRH1, PRL, INHA, PGR
4MP:00053899.5SRD5A2, BRCA1, BRCA2, GNRH1, CGA, PRL
5MP:00053909.5BRCA1, BRCA2, GNRH1, CYP19A1, INHA, PGR
6MP:00036319.3BRCA2, GNRH1, APOD, CGA, PRL, NR3C2
7MP:00053869.3BRCA1, BRCA2, APOD, PRL, NR3C2, CYP19A1
8MP:00053769.0BRCA1, BRCA2, GNRH1, APOD, CGA, PRL

Publications for Gynecomastia

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50PubMed
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Articles related to Gynecomastia:

(show top 50)    (show all 530)
idTitleAuthorsYear
1
Gynecomastia: etiologies, clinical presentations, diagnosis, and management. (24389786)
2014
2
Overexpression of Aromatase Associated With Loss of Heterozygosity of the STK11 Gene Accounts for Prepubertal Gynecomastia in Boys with Peutz-Jeghers Syndrome. (24037887)
2013
3
Efavirenz-induced gynecomastia in a prepubertal girl with human immunodeficiency virus infection: a case report. (23941256)
2013
4
Antidepressant-selective gynecomastia. (23324513)
2013
5
Two cases of male nipple leiomyoma: idiopathic leiomyoma and gynecomastia-associated leiomyoma. (22207446)
2012
6
Ductal carcinoma in situ and bilateral atypical ductal hyperplasia in a 23-year-old man with gynecomastia. (21944642)
2011
7
An unusual cause of infantile gynecomastia: sertoli cell tumor. (21358339)
2011
8
Hypogonadism and gynecomastia with duloxetine. (21298612)
2011
9
Displaced epithelium after liposuction for gynecomastia. (20519190)
2011
10
Assessment of vascularity with color Doppler ultrasound in gynecomastia. (20151357)
2010
11
Gynecomastia disclosing diagnosis of Leydig cell tumour in a man with thalassemia, secondary hypogonadism and testis microlithiasis. (20578425)
2009
12
Eccentric mastectomy and zigzag periareolar incision for gynecomastia. (19205793)
2009
13
Leydig cell hyperplasia revealed by gynecomastia. (18660859)
2008
14
Power-assisted liposuction and the pull-through technique for the treatment of gynecomastia. (18317124)
2008
15
Gynecomastia: a rare adverse effect of isoniazid. (19099106)
2008
16
Testicular seminoma presenting with mediastinal lymphadenopathy and gynecomastia. (17634885)
2007
17
Prepubertal gynecomastia linked to lavender and tea tree oils. (17568039)
2007
18
Gynecomastia associated with low-dose methotrexate therapy for rheumatoid arthritis. (18084706)
2007
19
Combined use of ultrasonic-assisted liposuction and semicircular periareolar incision for the treatment of gynecomastia. (18046142)
2007
20
Bilateral gynecomastia with microcalcifications in an HIV infected hemophilia A patient after HAART. (17274593)
2006
21
Studies on the interactions between drugs and estrogen. III. Inhibitory effects of 29 drugs reported to induce gynecomastia on the glucuronidation of estradiol. (15516735)
2004
22
The effect of tamoxifen on sex hormone binding globulin in adolescents with pubertal gynecomastia. (15379424)
2004
23
Editorial comment: unraveling the cause of HIV-related gynecomastia. (14959702)
2004
24
Another emerging event occurring during HIV infection treated with any antiretroviral therapy: frequency and role of gynecomastia. (15329529)
2004
25
HIV-related gynecomastia. (12603389)
2003
26
Male gynecomastia and risk for malignant tumours--a cohort study. (12383352)
2002
27
Gynecomastia and sexual impotence associated with methotrexate treatment. (12180746)
2002
28
Gynecomastia with sulpiride. (11846864)
2002
29
Occult Leydig cell tumor in a patient with gynecomastia. (11497478)
2001
30
Gynecomastia associated with highly active antiretroviral therapy. (11302408)
2001
31
Management of gynecomastia due to use of anabolic steroids in bodybuilders. (11176630)
2001
32
Isolated relapse of acute lymphoblastic leukemia in the breast masquerading as gynecomastia. (10896624)
2000
33
Alternatives for the surgical correction of severe gynecomastia. (9456358)
1998
34
Gynecomastia of the male nipple. (9641293)
1998
35
Gynecomastia associated with indinavir therapy. (9868681)
1998
36
Secondary surgery for failed gynecomastia correction from liposuction. (19328117)
1998
37
Pectoralis major ruptures postsuction lipectomy for surgical management of gynecomastia. (9456349)
1998
38
Cost-effective management of gynecomastia. (9926805)
1998
39
Irradiation therapy prevents gynecomastia in sex offenders treated with antiandrogens. (9721827)
1998
40
Evaluation and treatment of gynecomastia. (9105209)
1997
41
Clinically occult Leydig cell tumor in a cryptorchid man. Report of a case presenting with unilateral gynecomastia and impotence. (9358228)
1997
42
Androstenedione aromatization as a cause of gynecomastia in 11beta-hydroxylase and 21-hydroxylase deficiencies. (15251547)
1996
43
Nipple pain with jogging following gynecomastia excision. (7892335)
1995
44
Gynecomastia. (7704756)
1994
45
Metastatic hepatocellular carcinoma of the breast, simulating gynecomastia: diagnosis by fine-needle aspiration biopsy. (1334827)
1992
46
Modified technique for correction of gynecomastia. (1546102)
1992
47
Gynecomastia. Liposuction and excision. (1934894)
1991
48
Gynecomastia. Treatment by liposuction subcutaneous mastectomy. (2199107)
1990
49
Adolescent gynecomastia. Differential diagnosis and management. (2259545)
1990
50
Leydig-cell tumor of the testis with gynecomastia and elevated estrogen levels. (868795)
1977

Genetic Variations for Gynecomastia

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Expression for genes affiliated with Gynecomastia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gynecomastia

Search GEO for disease gene expression data for Gynecomastia.

Pathways for genes affiliated with Gynecomastia

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37NCBI BioSystems Database, 53Reactome, 49PharmGKB, 12EMD Millipore, 29KEGG
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Pathways related to Gynecomastia according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3HSD17B3, CYP19A1
2
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10.2CYP19A1, ESR1
3
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10.2CGA, GNRH1
4
Estrone metabolism
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10.2CYP17A1, CYP19A1, HSD17B3
510.1CYP17A1, CYP19A1, CGA
610.1CYP19A1, INHA, PGR
7
Transcription Androgen Receptor nuclear signaling
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10.1SRD5A2, SRD5A1, KLK3
810.0ESR1, BRCA1, KLK3
9
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10.0NR3C2, PGR, ESR1
10
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10.0KLK3, HSD17B3, BRCA1, CYP17A1
11
Hide members
10.0HSD17B3, CYP17A1, SRD5A1, SRD5A2
12
Development Prolactin receptor signaling
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9.9ESR1, CYP17A1, PRL, CGA
13
Hide members
9.9SRD5A2, BRCA2, BRCA1, KLK3
149.9BRCA1, BRCA2, CYP19A1, ESR1
15
Hide members
9.9SRD5A2, SRD5A1, CYP17A1, CYP19A1, HSD17B3

Compounds for genes affiliated with Gynecomastia

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Gynecomastia according to GeneCards/GeneDecks:

(show top 50)    (show all 221)
idCompoundScoreTop Affiliating Genes
1estrogen4410.5KLK3, SRD5A1
2goserelin44 28 1112.4CGA, GNRH1, SRD5A1
3ment4410.2ESR1, CYP19A1, SHBG, KLK3, SRD5A1
4cycloheximide4410.1KLK3, BRCA2, BRCA1, CGB5
511 deoxycortisol4410.1SHBG, PRL, CGA, NR3C2, CYP17A1
6toremifene44 1111.0ESR1, PGR, PRL, GNRH1, SHBG, CYP19A1
7danazol44 11 2412.0GNRH1, PGR, PRL, SHBG, CYP19A1, ESR1
8letrozole44 49 59 1113.0SHBG, CYP17A1, ESR1, PGR, CYP19A1, CGA
9cyproteroneacetate4410.0KLK3, GNRH1, PRL, SHBG, CYP19A1, PGR
10exemestane49 44 59 1113.0ESR1, SRD5A1, PGR, CYP19A1, SHBG, CYP17A1
11megestrol acetate4410.0KLK3, SHBG, PGR, CYP19A1, ESR1
12leuprolide44 59 28 1113.0GNRH1, SRD5A1, CGB5, PRL, KLK3, CGA
13anastrozole44 1111.0SHBG, CYP19A1, PGR, CGA, ESR1
14buserelin44 28 1112.0GNRH1, CGA, CGB5, PRL, CYP19A1, PGR
15estrone sulfate44 2411.0PRL, ESR1, PGR, CYP17A1, CYP19A1, SHBG
16levonorgestrel44 59 28 1113.0CYP19A1, ESR1, SRD5A1, PGR, PRL, SHBG
17aminoglutethimide44 1111.0KLK3, CGB5, CYP19A1, ESR1, NR3C2
18estradiol benzoate449.9PGR, ESR1, CYP19A1, PRL, CGB5, GNRH1
19spironolactone49 44 59 28 1113.9SRD5A1, KLK3, PGR, GNRH1, SHBG, NR3C2
20hydroxyflutamide44 2810.9KLK3, SRD5A1, ESR1, SHBG, CGA
21steroidal449.8SRD5A1, ESR1, CYP17A1, CYP19A1, NR3C2, GNRH1
2217-hydroxyprogesterone44 2410.8GNRH1, CGA, CGB5, PRL, SHBG, CYP19A1
23tibolone449.8GNRH1, CYP19A1, PGR, ESR1, SHBG
24clomiphene citrate449.8GNRH1, CGA, CGB5, PRL, SHBG, CYP19A1
25progestins449.8KLK3, GNRH1, SHBG, NR3C2, CYP19A1, PGR
26dhea449.7PRL, CGB5, KLK3, SHBG, CYP19A1, CYP17A1
27finasteride44 59 11 2412.7SHBG, KLK3, SRD5A2, SRD5A1, CYP19A1
28flutamide44 59 1111.7ESR1, SRD5A1, PGR, CYP19A1, KLK3, GNRH1
29leuprolide acetate449.7ESR1, PGR, CYP19A1, KLK3, GNRH1, CGA
30dehydroepiandrosterone sulfate449.7GNRH1, CGA, CGB5, PRL, CYP17A1, SRD5A1
31diethylstilbestrol44 28 1111.7KLK3, GNRH1, CGA, CGB5, SHBG, CYP19A1
323beta-hydroxysteroid449.7CGA, CGB5, NR3C2, CYP19A1, CYP17A1, INHA
33mifepristone44 59 28 1112.7PGR, ESR1, CYP19A1, NR3C2, SHBG, GNRH1
34formestane449.6SHBG, CYP19A1, SRD5A1, ESR1
35estrone44 28 11 2412.6ESR1, CYP17A1, SRD5A1, HSD17B3, GNRH1, CGB5
36ribonucleic acid449.6NR3C2, GNRH1, CGA, CGB5, CYP17A1, SRD5A2
37vitamin d449.6SRD5A1, SRD5A2, SHBG, KLK3, CYP17A1, CGA
38androstenedione44 2410.6HSD17B3, GNRH1, CGA, CGB5, PRL, SHBG
3917beta-hydroxysteroid449.5HSD17B3, BRCA1, CGA, CGB5, CYP19A1, CYP17A1
40progestin449.4GNRH1, CGA, CGB5, PRL, SHBG, NR3C2
41gnrh449.3KLK3, GNRH1, CGA, CGB5, PRL, SHBG
42paraffin449.3CGA, ESR1, PGR, CGB5, APOD, BRCA2
43tamoxifen44 49 28 1112.3CGA, PGR, CYP17A1, CYP19A1, SHBG, CGB5
44genistein44 28 59 2 11 2414.2BRCA2, BRCA1, ESR1, CGB5, CYP17A1, SRD5A1
45retinoic acid44 2410.1SHBG, NR3C2, SRD5A1, CYP17A1, CYP19A1, PGR
46dihydrotestosterone44 28 11 2411.9KLK3, GNRH1, APOD, CGA, CGB5, PRL
47progesterone44 59 28 11 2412.7BRCA1, CYP19A1, NR3C2, SHBG, PRL, CGB5
48estradiol44 11 2410.5SHBG, NR3C2, CYP19A1, CYP17A1, INHA, PGR
49steroid448.5KLK3, BRCA1, BRCA2, GNRH1, APOD, SRY
50testosterone44 59 11 2411.4KLK3, HSD17B3, BRCA1, BRCA2, GNRH1, APOD

GO Terms for genes affiliated with Gynecomastia

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Sources:
16Gene Ontology
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Cellular components related to Gynecomastia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.6GNRH1, APOD, CGA, PRL, SHBG, INHA
2endoplasmic reticulum membraneGO:0057899.4SRD5A2, SRD5A1, CYP17A1, CYP19A1, NR3C2, HSD17B3

Biological processes related to Gynecomastia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1androgen metabolic processGO:00820910.2ESR1, SRD5A2, CYP19A1
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.2BRCA2, BRCA1
3androgen biosynthetic processGO:00670210.1SRD5A2, SRD5A1, CYP17A1, HSD17B3
4ovulation cycleGO:04269810.1GNRH1, PRL
5male gonad developmentGO:00858410.1INHA, SRY, SRD5A2, ESR1
6steroid metabolic processGO:00820210.0HSD17B3, CYP19A1, CYP17A1, SRD5A1, SRD5A2
7cell-cell signalingGO:0072679.9SRD5A2, PGR, INHA, CGA, GNRH1
8signal transductionGO:0071659.3ESR1, PGR, INHA, NR3C2, CGA, GNRH1

Molecular functions related to Gynecomastia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholestenone 5-alpha-reductase activityGO:04775110.1SRD5A1, SRD5A2
2hormone activityGO:00517910.1INHA, PRL, CGA, GNRH1
3steroid bindingGO:00549610.0ESR1, PGR, NR3C2
4steroid hormone receptor activityGO:00370710.0ESR1, PGR, NR3C2
53-oxo-5-alpha-steroid 4-dehydrogenase activityGO:0038659.9SRD5A1, SRD5A2

Products for genes affiliated with Gynecomastia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gynecomastia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet