Gynecomastia malady

Wikipedia: Gynecomastia, pron.: /ˌɡaɪnɨkɵˈmæstiə/, is the abnormal development of large mammary glands in...⁴⁴ more...

MalaCards: Gynecomastia, also known as gynecomastia (disorder), is related to prostate cancer and 17-beta hydroxysteroid dehydrogenase 3 deficiency. An important gene associated with Gynecomastia is HSD17B3 (hydroxysteroid (17-beta) dehydrogenase 3), and among its related pathways are Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics and Estrogen biosynthesis. The drugs tamoxifen and tamoxifen citrate and the compounds estradiol benzoate and goserelin have been mentioned in the context of this disorder. Affiliated tissues include lung, breast and prostate, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

Aliases & Descriptions:

gynecomastia 6 7 8 32 43 gynecomastia (disorder) 6

gynaecomastia 6

Diseases related to gynecomastia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 389)

id	Related Disease	Score	Top Affiliating Genes
1	prostate cancer	30.3	AR, SRD5A1, KLK3
2	17-beta hydroxysteroid dehydrogenase 3 deficiency	30.0	HSD17B3, SRD5A1
3	peutz-jeghers syndrome	29.7	BRCA2, INHA, CYP19A1, STK11
4	aromatase excess syndrome	28.3	CGB5, CGNL1, CYP19A1, POMC
5	aromatase deficiency	28.0	GNRH1, ESR1, CYP19A1
6	21-hydroxylase deficiency	27.9	INHA, CYP21A2
7	3-beta-hydroxysteroid dehydrogenase deficiency	27.8	HSD3BP4, CYP17A1, CYP21A2
8	large cell carcinoma	27.5	CGA, CGB5, STK11
9	varicocele	27.1	BRD2, CGA, CGB5, GNRH1, ESR1, SHBG
10	breast cancer	26.6	BRCA1, BRCA2, AR, ESR1, ERBB2, CYP19A1
11	sertoli cell tumor	25.8	MUC1, CGB, CGB5, AR, INHA, CYP19A1
12	male breast cancer	25.8	BRCA1, BRCA2, AR, APOD, ESR1, ERBB2
13	hypospadias	25.7	BRD2, CGA, AR, HSD17B3, ESR1, CYP17A1
14	leydig cell tumor	25.6	BRD2, MUC1, CGA, CGB, CGB5, INHA
15	transsexualism	25.5	LEP, AR, GNRH1, ESR1, CYP17A1, CYP19A1
16	pseudohermaphroditism	24.9	BRD2, CGB5, AR, HSD17B1P1, HSD17B3, HSD3BP4
17	klinefelter's syndrome	23.5	BRD2, LEP, CGA, CGB, AR, INHA
18	hypogonadism	23.3	RBM28, BRD2, LEP, CGA, CGB5, AR
19	hepatocellular carcinoma	22.7	BTF3, BRCA2, LEP, MUC1, CGA, AR
20	gastric cancer	22.2	BRCA1, BRCA2, LEP, MUC1, CGB5, AR
21	prostatitis	21.3	BRCA1, BRCA2, LEP, MUC1, CGA, CGB
22	squamous cell carcinoma	21.0	BTF3, BRCA2, LEP, MUC1, CGB, CGB5
23	carcinoma	20.6	BTF3, BRCA1, BRCA2, BRD2, LEP, MUC1
24	obesity	20.5	LEP, CGA, AR, INHA, GNRH1, ESR1
25	breast carcinoma	18.8	BRCA1, BRCA2, LEP, MUC1, CGA, CGB
26	adenocarcinoma	18.6	BRCA1, BRCA2, LEP, MUC1, CGA, CGB
27	anorchia	13.7	CGA, CGB5, SRY
28	lynch syndrome	13.7	BRCA1, BRCA2
29	brca1 and brca2 hereditary breast and ovarian cancer	13.7	BRCA1, BRCA2
30	trophoblastic neoplasm	13.7	CGA, CGB5, INHA
31	epithelioid trophoblastic tumor	13.7	CGA, CGB5, INHA
32	hypogonadism, hypergonadotropic	13.6	CYP19A1, SHBG, PRL
33	mixed epithelial stromal tumour	13.6	INHA, CYP19A1, PGR
34	leydig cell adenoma	13.6	CGA, GNRH1
35	gestational trophoblastic neoplasm	13.6	CGA, CGB5, INHA
36	hypothalamic disease	13.6	CGA, GNRH1, PRL
37	uterine disease	13.6	ESR1, CYP19A1
38	vulvar syringoma	13.6	ESR1, PGR
39	hydrocele	13.6	CGA, CGB5, ESR1
40	5-alpha reductase deficiency	13.6	CGA, CGB5, SRD5A1, SRD5A2
41	breast cyst	13.6	CGB5, APOD, CYP19A1, KLK3
42	synchronous bilateral breast carcinoma	13.6	BRCA2, PGR
43	ovarian cyst	13.6	CGA, CGB5, GNRH1, CYP19A1
44	primary ciliary dyskinesia	13.6	CGA, CYP19A1
45	benign metastasizing leiomyoma	13.6	ESR1, CYP19A1, PGR
46	catamenial pneumothorax	13.5	GNRH1, ESR1, PGR
47	aorta atresia	13.5	CGA, INHA, GNRH1, CYP19A1
48	swyer syndrome	13.5	CGB, SRY, SHBG
49	habitual abortion	13.5	CGB, CGB5
50	endodermal sinus tumor	13.5	CGB, CGB5, INHA

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 tamoxifen, tamoxifen citrate

MalaCards organs/tissues related to gynecomastia:

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MGI Mouse Phenotypes related to gynecomastia:

²⁵ (show all 17)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	9.9	BRCA1, BRCA2, BRD2, INHA, GNRH1
2	hematopoietic system phenotype	MP:0005397	9.7	BRCA1, BRCA2, INHA, STK11
3	liver/biliary system phenotype	MP:0005370	9.4	POR, PRL, CYP19A1, AR, BRD2
4	nervous system phenotype	MP:0003631	8.3	POMC, POR, PRL, STK11, CYP19A1, GNRH1
5	embryogenesis phenotype	MP:0005380	8.2	PGR, POR, PRL, STK11, ERBB2, BRD2
6	adipose tissue phenotype	MP:0005375	7.8	POMC, CYP19A1, ESR1, AR, LEP, BRD2
7	renal/urinary system phenotype	MP:0005367	7.6	POMC, POR, STK11, NR3C2, ESR1, GNRH1
8	behavior/neurological phenotype	MP:0005386	7.6	STK11, PRL, POR, POMC, PGR, NR3C2
9	reproductive system phenotype	MP:0005389	7.5	SRD5A2, SRY, STK11, PRL, POR, SRD5A1
10	skeleton phenotype	MP:0005390	7.5	PGR, CYP19A1, ERBB2, ESR1, GNRH1, INHA
11	mortality/aging	MP:0010768	7.5	CYP17A1, SRY, NR3C2, STK11, POR, APOD
12	digestive/alimentary phenotype	MP:0005381	7.3	GNRH1, ESR1, ERBB2, STK11, INHA, AR
13	growth/size phenotype	MP:0005378	6.9	ERBB2, CYP19A1, NR3C2, STK11, POR, GNRH1
14	tumorigenesis	MP:0002006	6.5	ERBB2, STK11, PRL, POMC, PGR, ESR1
15	cardiovascular system phenotype	MP:0005385	6.5	NR3C2, STK11, POR, POMC, PGR, CYP19A1
16	integument phenotype	MP:0010771	6.5	CYP19A1, STK11, PRL, POMC, PGR, ERBB2
17	homeostasis/metabolism phenotype	MP:0005376	5.2	ERBB2, CYP17A1, CYP19A1, NR3C2, STK11, PRL

Articles related to gynecomastia:

(show top 50)    (show all 59)

id	Title	Authors	Year	Affiliating Genes
1	Venlafaxine-induced gynecomastia in a young patient: a case report. (18978497)	Karakurt F.... Ozbek M.	2009	PRL
2	Gynecomastia in prepubertal and pubertal men. (18622206)	Ma N.S.... Geffner M.E.	2008	CYP19A1
3	Association between gynecomastia and aromatase (CYP19) polymorphisms. (18426832)	Czajka-Oraniec I.... Ostrowski J.	2008	CYP19A1
4	Gynecomastia: review. (17925790)	Abaci A.... Buyukgebiz A.	2007	PRL
5	Gynecomastia. (17543732)	Narula H.S.... Carlson H.E.	2007	CYP19A1
6	Prepubertal gynecomastia in Peutz-Jeghers syndrome: incomplete penetrance in a familial case and management with an aromatase inhibitor. (16452534)	Lefevre H.... Carel J.C.	2006	CYP19A1, INHA
7	Sertoli cell tumor causing prepubertal gynecomastia in a boy with peutz-jeghers syndrome: the outcome of 1-year treatment with the aromatase inhibitor testolactone. (15947469)	Kara C.... Senel F.	2005	CYP19A1
8	Incidence and management of gynecomastia in men treat ed for prostate cancer. (16217274)	Dobs A.... Darkes M.J.	2005	CYP19A1
9	Leptin levels in boys with pubertal gynecomastia. (16355805)	Dundar B.... BA1yA1kgebiz A.	2005	ESR1, LEP, CYP19A1
10	Possible involvement of aromatase overexpression induced by cyclo-oxygenase-2 in the pathogenesis of idiopathic gynecomastia. (16392624)	Irahara N.... Harada N.	2005	CYP19A1
11	Aromatase-dependent gynecomastia in a patient with adenocarcinoma of the lung (16238933)	GutiAcrrez-Santiago M.... Riancho J.A.	2005	CYP19A1
12	Evaluation of tamoxifen and anastrozole in the prevention of gynecomastia and breast pain induced by bicalutamide monotherapy of prostate cancer. (15681525)	Boccardo F.... Montefiore F.	2005	KLK3
13	Dominant transmission of prepubertal gynecomastia due to serum estrone excess: hormonal, biochemical, and genetic analysis in a large kindred. (15483104)	Binder G.... Schmidt M.	2005	CYP19A1
14	Gynecomastia and breast pain induced by adjuvant therapy with bicalutamide after radical prostatectomy in patients with prostate cancer: the role of tamoxifen and radiotherapy. (16280763)	Di Lorenzo G.... Autorino R.	2005	KLK3
15	Beneficial effects of raloxifene and tamoxifen in the treatment of pubertal gynecomastia. (15238910)	Lawrence S.E.... Lawson M.L.	2004	ESR1
16	The effect of tamoxifen on sex hormone binding globulin in adolescents with pubertal gynecomastia. (15379424)	Derman O.... Tokur T.E.	2004	SHBG
17	Gynecomastia due to hormone therapy for advanced prostate cancer: a report of ten surgically treated cases and a review of treatment options. (15510985)	Prezioso D.... Lotti T.	2004	CYP19A1
18	Differential expressions of BRCA1 and BRCA2 in infantile gynecomastia. (15015615)	Bernard-Gallon D.J.... Bignon Y.J.	2004	BRCA1, BRCA2
19	Treatment of testosterone-induced gynecomastia with the aromatase inhibitor, anastrozole. (14963480)	Rhoden E.L.... Morgentaler A.	2004	CYP19A1
20	An elderly case of advanced gastric cancer with gynecomastia and high serum levels of hCG (12404754)	Yamamoto J.... Hashimoto T.	2002	CGB5
21	On the inhibitory action of 29 drugs having side effect gynecomastia on estrogen production. (12477487)	Satoh T.... Yoshizawa I.	2002	CYP19A1, ARSH
22	Gynecomastia with sulpiride. (11846864)	Kaneda Y.... Fujii A.	2002	PRL
23	Occult Leydig cell tumor in a patient with gynecomastia. (11497478)	Anderson M.S.... Biller B.M.	2001	PRL
24	Overexpression of aromatase in transgenic male mice results in the induction of gynecomastia and other biochemical changes in mammary glands. (11358670)	Gill K.... Tekmal R.R.	2001	CYP19A1
25	Serum inhibin B concentration in a prepubertal boy with gynecomastia and Peutz-Jeghers syndrome. (10689645)	BergadA! I.... Campo S.	2000	CYP19A1
26	Studies on the interactions between drugs and estrogen: analytical method for prediction system of gynecomastia induced by drugs on the inhibitory metabolism of estradiol using Escherichia coli coexpressing human CYP3A4 with human NADPH-cytochrome P450 reductase. (11067738)	Satoh T.... Yoshizawa I.	2000	POR, CYP3A4
27	Immunohistochemical localization of prostate-specific antigen in ductal epithelium of male breast. Potential diagnostic pitfall in patients with gynecomastia. (10937064)	Gatalica Z.... Kovatich A.J.	2000	KLK3
28	Estrogen and progesterone receptors in gynecomastia. (11039372)	Pensler J.M.... Molteni A.	2000	PGR
29	Aromatase and gynecomastia. (10731125)	Braunstein G.D.	1999	CYP19A1
30	Gynecomastia with risperidone-fluoxetine combination. (10071182)	Benazzi F.	1999	PRL
31	Cost-effective management of gynecomastia. (9926805)	Bowers S.P.... Huerd S.	1998	CGB
32	Hormonal profile of patients with Leydig cell tumors: a urologic cause of gynecomastia. (9973810)	Xciarra A.... Di Silverio F.	1998	CGB5
33	Molecular basis of severe gynecomastia associated with aromatase expression in a fibrolamellar hepatocellular carcinoma. (9589695)	Agarwal V.R.... Bulun S.E.	1998	CYP19A1
34	Report of an XX male with hypospadias and pubertal gynecomastia, SRY gene negative in blood leukocytes but SRY gene positive in testicular cells. (9030973)	Dardis A.... Belgorosky A.	1997	SRY
35	Tamoxifen for flutamide/finasteride-induced gynecomastia. (9426725)	Staiman V.R.... Lowe F.C.	1997	KLK3
36	Gynecomastia and Leydig cell tumor (9235082)	CatalA! Bauset M.... GonzA!lez-Bayo E.	1997	CGA
37	Androstenedione aromatization as a cause of gynecomastia in 11beta-hydroxylase and 21-hydroxylase deficiencies. (15251547)	Blackett MD P.R.... Freeman MD D.A.	1996	CYP21A2
38	Clinical studies on changes in sexual hormones and estrogen receptor in patients with gynecomastia (8706561)	Pei W.... Lixia Z.	1995	ESR1
39	A case of hCG-alpha and beta complex producing lung squamous cell carcinoma associated with gynecomastia (7616092)	Tamaki M.... Fukuoka H.	1995	BTF3
40	Gynecomastia with unusual intraductal 'clear cel l' changes mimicking pagetoid ductal spread of lobular neoplasia. (7567685)	Guillou L.... Gebhard S.	1995	MUC1
41	Reduction of telomeric length and c-erbB-2 gene amplification in human breast cancer, fibroadenoma, and gynecomastia. Relationship to histologic grade and clinical parameters. (7911069)	Odagiri E.... Demura H.	1994	ERBB2
42	Partial 3 beta-hydroxysteroid dehydrogenase deficiency presenting as new-onset gynecomastia in a eugonadal adult male. (8446050)	Cavanah S.F.... Dons R.F.	1993	HSD3BP4
43	Metastatic hepatocellular carcinoma of the breast, simulating gynecomastia: diagnosis by fine-needle aspiration biopsy. (1334827)	Nappi O.... Wick M.R.	1992	MUC1
44	Role of testosterone and dihydrotestosterone in spont aneous gynecomastia of adolescents. (1530365)	Villalpando S.... CortAcs-Gallegos V.	1992	PRL, SRD5A1
45	Gynecomastia and ectopic human chorionic gonadotropin production by transitional cell carcinoma of the bladder. (1413316)	Nishiyama T.... Sato S.	1992	CGB5
46	Elevated serum estradiol associated with increased androstenedione-testosterone ratio in adolescent males with varicocele and gynecomastia. (1894030)	Castro-Magana M.... Uy J.	1991	CGB5
47	New X-linked syndrome of mental retardation, gynecomastia, and obesity is linked to DXS255. (1746601)	Wilson M.... Turner G.	1991	WTS
48	Changes in leucocytic estrogen receptor levels in patients with gynecomastia (1874085)	Zhou D.J.... Qiao D.B.	1991	ESR1
49	Hormonal studies and physical maturation in adolescent gynecomastia. (2137877)	Biro F.M.... Morrison J.A.	1990	SHBG
50	Occurrence of gynecomastia during prolonged pulsatile administration of gonadorelin (2142288)	Lefebvre H.... Wolf L.M.	1990	GNRH1

Genes related to gynecomastia according to GeneCards:

(show all 39)

id	Symbol	Description	Score	GeneCards Section Context
1	HSD17B3	hydroxysteroid (17-beta) dehydrogenase 3	11.1	Summaries
2	WTS	Wilson-Turner X-linked mental retardation syndrome	11.0	Publications
3	SRY	sex determining region Y	11.0	Publications
4	INHA	inhibin, alpha	11.0	Publications
5	CGB5	chorionic gonadotropin, beta polypeptide 5	11.0	Publications
6	CYP19A1	cytochrome P450, family 19, subfamily A, polypeptide 1	11.0	Publications
7	APOD	apolipoprotein D	11.0
8	SRD5A2	steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)	11.0
9	SHBG	sex hormone-binding globulin	11.0	Publications
10	SRD5A1	steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)	11.0	Publications
11	CYP17A1	cytochrome P450, family 17, subfamily A, polypeptide 1	11.0
12	CGA	glycoprotein hormones, alpha polypeptide	11.0	Publications
13	KLK3	kallikrein-related peptidase 3	11.0	Publications
14	GNRH1	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)	11.0	Publications
15	PRL	prolactin	11.0	Publications
16	BRCA1	breast cancer 1, early onset	11.0	Publications
17	BRCA2	breast cancer 2, early onset	11.0	Publications
18	NR3C2	nuclear receptor subfamily 3, group C, member 2	11.0
19	PGR	progesterone receptor	11.0	Publications
20	ESR1	estrogen receptor 1	11.0	Publications
21	HSD17B1P1	hydroxysteroid (17-beta) dehydrogenase 1 pseudogene 1	11.0
22	BTF3	basic transcription factor 3	11.0	Publications
23	PHF6	PHD finger protein 6	11.0
24	RBM28	RNA binding motif protein 28	11.0
25	HSD3BP4	hydroxy-delta-5-steroid dehydrogenase, 3 beta, pseudogene 4	11.0	Publications
26	ARSH	arylsulfatase family, member H	11.0	Publications
27	CGB	chorionic gonadotropin, beta polypeptide	11.0	Publications
28	DMXL2	Dmx-like 2	11.0
29	BRD2	bromodomain containing 2	11.0
30	CYP21A2	cytochrome P450, family 21, subfamily A, polypeptide 2	11.0	Publications
31	POR	P450 (cytochrome) oxidoreductase	11.0	Publications
32	STK11	serine/threonine kinase 11	11.0
33	CGNL1	cingulin-like 1	11.0
34	MUC1	mucin 1, cell surface associated	11.0	Publications
35	AR	androgen receptor	11.0
36	CYP3A4	cytochrome P450, family 3, subfamily A, polypeptide 4	11.0	Publications
37	POMC	proopiomelanocortin	11.0	Publications
38	ERBB2	v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)	11.0	Publications
39	LEP	leptin	11.0	Publications

Pathways related to gynecomastia according to GeneDecks:

(show all 14)

id	Pathway	Score	Top Affiliating Genes
1	Aromatase Inhibitor Pathway (Breast Cell), Pharmacodynamics34	10.2	ESR1, CYP19A1
2	Estrogen biosynthesis41	10.0	CYP19A1, CYP3A4, HSD17B3
3	Estrogen biosynthesis10	10.0	CYP19A1, CYP3A4, HSD17B3
4	Androstenedione and testosterone biosynthesis and metabolism p.141	9.9	CYP17A1, CYP3A4, HSD17B3
5	Androstenedione and testosterone biosynthesis and metabolism p.110	9.9	CYP17A1, CYP3A4, HSD17B3
6	Transcription_Androgen Receptor nuclear signaling41	9.6	KLK3, SRD5A2, SRD5A1, AR
7	Metabolism of lipids and lipoproteins38	9.6	SRD5A2, SRD5A1, CYP21A2, CYP19A1, CYP17A1, HSD17B3
8	Transcription Androgen Receptor nuclear signaling10	9.5	AR, SRD5A1, SRD5A2, KLK3
9	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.5	CGA, AR, CYP3A4, CYP19A1
10	Transcription Role of VDR in regulation of genes involved in osteoporosis10	9.4	CYP19A1, CYP3A4, AR, CGA
11	Steroid hormone biosynthesis20	9.3	HSD17B3, SRD5A2, SRD5A1, CYP21A2, CYP19A1, CYP17A1
12	Translation_Non-genomic (rapid) action of Androgen Receptor41	9.1	SRD5A2, SRD5A1, ERBB2, AR
13	Translation Non-genomic (rapid) action of Androgen Receptor10	9.0	AR, ERBB2, SRD5A1, SRD5A2
14	Prostate cancer20	8.6	KLK3, SRD5A2, ERBB2, AR

Compounds related to gynecomastia according to GeneDecks:

(show top 50)    (show all 278)

id	Compound	Score	Top Affiliating Genes
1	estradiol benzoate32	9.8	CGB5, GNRH1, ESR1, CYP19A1, PRL, PGR
2	goserelin32 9 9	11.7	CGA, GNRH1, ESR1, CYP19A1, SRD5A1, SHBG
3	toremifene32 9 9	11.6	ERBB2, CYP19A1, PRL, PGR
4	anastrozole32 42 9 9	12.6	ESR1, ERBB2
5	buserelin32 9 9	11.5	CYP19A1, KLK3, PRL, PGR, CGB5, GNRH1
6	leuprolide32 42 9 9	12.4	KLK3, PRL, CGA, SRD5A1, CGB5, AR
7	leuprolide acetate32	9.3	ESR1, CYP19A1, CYP21A2, SHBG, KLK3, PRL
8	cyproteroneacetate32	9.3	GNRH1, CYP19A1, AR, SRD5A1, KLK3, PGR
9	clomiphene citrate32	9.1	CGA, CGB, CGB5, GNRH1, ESR1, CYP19A1
10	11 deoxycortisol32	9.0	CGA, NR3C2, POMC, CYP17A1, CYP21A2, SHBG
11	dutasteride32 9 9	11.0	KLK3, AR, CYP3A4, CYP19A1, SRD5A1, SRD5A2
12	progestin32	9.0	CGA, CGB5, AR, GNRH1, HSD3BP4, CYP17A1
13	androstenediol32	9.0	SRD5A1, CYP19A1, SHBG, KLK3, AR, ARSH
14	steroidal32	8.9	ARSH, AR, GNRH1, HSD3BP4, ESR1, CYP17A1
15	progestins32	8.9	AR, GNRH1, ESR1, CYP19A1, SRD5A1, NR3C2
16	17-hydroxypregnenolone32	8.9	POMC, POR, CGA, CGB5, HSD3BP4, CYP17A1
17	danazol32 9 18 9	11.8	ARSH, AR, GNRH1, ESR1, CYP3A4, CYP19A1
18	levonorgestrel32 9 9	10.8	CYP3A4, PGR, PRL, SRD5A1, CYP19A1, AR
19	finasteride32 42 9 18 9	12.8	AR, CYP19A1, SRD5A1, SRD5A2, SHBG, KLK3
20	spironolactone32 42 34 9 9	12.6	KLK3, POMC, PGR, SHBG, NR3C2, SRD5A1
21	flutamide32 9 9	10.6	PGR, PRL, KLK3, CGA, AR, GNRH1
22	epinephrine32 9 18 9	11.4	LEP, CGA, CGB5, GNRH1, CYP21A2, SHBG
23	17-hydroxyprogesterone32 18	9.4	CGA, CGB5, GNRH1, HSD3BP4, CYP17A1, CYP19A1
24	diethylstilbestrol32 9 9	10.3	CGA, CGB5, AR, GNRH1, ESR1, CYP3A4
25	exemestane32 34 9 9	11.3	SHBG, PGR, SRD5A1, CYP19A1, CYP3A4, AR
26	17beta-hydroxysteroid32	8.2	BRCA1, CGA, CGB5, ARSH, AR, HSD17B3
27	aminoglutethimide32 9 9	10.2	CGB5, AR, ESR1, CYP3A4, CYP19A1, CYP21A2
28	megestrol acetate32	8.2	LEP, ESR1, ERBB2, CYP19A1, SHBG, KLK3
29	ketoconazole32 42 9 18 9	12.1	POMC, KLK3, SHBG, AR, HSD3BP4, CYP3A4
30	ribonucleic acid32	8.1	MUC1, CGA, CGB5, INHA, GNRH1, HSD3BP4
31	letrozole32 42 9 9	10.8	LEP, CGA, AR, ESR1, ERBB2, CYP3A4
32	gnrh32	7.8	LEP, CGB, CGB5, ARSH, AR, INHA
33	3beta-hydroxysteroid32	7.7	CGA, CGB5, AR, INHA, HSD3BP4, CYP17A1
34	acth32	7.7	CYP21A2, POMC, SHBG, NR3C2, CYP17A1, HSD3BP4
35	dehydroepiandrosterone sulfate32	7.3	PRL, POMC, KLK3, SHBG, SRD5A1, LEP
36	estrone32 9 18 9	10.2	AR, GNRH1, HSD17B3, HSD3BP4, ESR1, CYP3A4
37	dhea32	7.1	LEP, CGB5, ARSH, AR, HSD3BP4, CYP17A1
38	hydrocortisone32 9 9	9.1	POMC, PRL, MUC1, KLK3, NR3C2, ERBB2
39	mifepristone32 42 9 9	10.1	HSD3BP4, ESR1, CYP3A4, CYP19A1, NR3C2, SHBG
40	dihydrotestosterone32 9 18 9	9.4	ARSH, APOD, CYP21A2, SRD5A1, SRD5A2, SRY
41	cycloheximide32	6.4	BRCA2, LEP, CGB5, AR, ERBB2, CYP17A1
42	paraffin32	6.3	LEP, MUC1, CGA, CGB5, AR, INHA
43	androstenedione32 18	7.1	CGB, CGB5, AR, INHA, GNRH1, HSD17B3
44	tamoxifen32 34 9 9	9.1	BRCA1, BRCA2, LEP, CGA, CGB5, ARSH
45	dexamethasone32 42 34 9 9	9.3	PGR, POMC, LEP, MUC1, CGB5, AR
46	testosterone32 9 18 9	8.1	ARSH, PGR, POR, AR, INHA, APOD
47	estradiol32 9 18 9	7.7	CGB, BRCA1, BRCA2, LEP, MUC1, CGA
48	steroid32	4.2	SRD5A2, SRY, NR3C2, SHBG, KLK3, PRL
49	progesterone32 42 9 18 9	8.2	BRCA1, BRCA2, LEP, MUC1, CGA, CGB
50	estrogen32	4.1	BRCA1, BRCA2, LEP, MUC1, CGA, CGB

Cellular components related to gynecomastia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	neuronal cell body	GO:043025	9.9	CYP19A1, CYP17A1, APOD, INHA, SRD5A1
2	endoplasmic reticulum membrane	GO:005789	8.5	HSD17B3, POR, NR3C2, SRD5A2, SRD5A1, CYP21A2
3	extracellular region	GO:005576	7.4	POMC, PRL, KLK3, SHBG, GNRH1, APOD

Biological processes related to gynecomastia according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	androgen biosynthetic process	GO:006702	10.3	SRD5A2, SRD5A1, CYP17A1, HSD17B3
2	phthalate metabolic process	GO:018963	10.1	CYP19A1, CYP17A1
3	hippocampus development	GO:021766	10.1	CYP17A1, CYP19A1, SRD5A1
4	positive regulation of steroid hormone biosynthetic process	GO:090031	10.0	CYP17A1, POR
5	response to ionizing radiation	GO:010212	9.9	BRCA1, CYP17A1, CYP19A1, STK11
6	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	GO:006978	9.9	MUC1, BRCA2, BRCA1
7	biphenyl metabolic process	GO:018879	9.9	CYP19A1, CYP17A1
8	androgen metabolic process	GO:008209	9.9	CYP3A4, CYP19A1, SRD5A2
9	sex differentiation	GO:007548	9.8	SRY, CYP17A1, AR
10	male gonad development	GO:008584	9.8	SRD5A2, SRD5A1, CYP19A1, INHA, AR
11	peptide hormone processing	GO:016486	9.6	CGA, CGB, POMC
12	steroid metabolic process	GO:008202	9.3	HSD17B3, SRD5A2, SRD5A1, CYP21A2, CYP19A1, CYP17A1
13	cell-cell signaling	GO:007267	8.7	PGR, POMC, SRD5A2, GNRH1, INHA, AR
14	small molecule metabolic process	GO:044281	7.7	POMC, STK11, SRD5A2, SRD5A1, CYP21A2, CYP19A1
15	signal transduction	GO:007165	7.5	PGR, POMC, NR3C2, ERBB2, ESR1, GNRH1

Molecular functions related to gynecomastia according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	3-oxo-5-alpha-steroid 4-dehydrogenase activity	GO:003865	10.1	SRD5A1, SRD5A2
2	progesterone 5-alpha-reductase activity	GO:050213	9.9	SRD5A1, SRD5A2
3	oxygen binding	GO:019825	9.7	CYP3A4, CYP17A1, CYP19A1
4	steroid binding	GO:005496	9.3	PGR, NR3C2, CYP21A2, CYP3A4, ESR1
5	iron ion binding	GO:005506	9.1	POR, CYP21A2, CYP19A1, CYP17A1, CYP3A4
6	electron carrier activity	GO:009055	9.1	POR, SRD5A1, CYP21A2, CYP19A1, CYP17A1, CYP3A4
7	enzyme binding	GO:019899	8.7	PGR, POR, CYP3A4, ESR1, AR, BRCA1
8	hormone activity	GO:005179	8.7	LEP, CGA, CGB, INHA, GNRH1, PRL