Summaries for Gynecomastia

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Wikipedia:63 Gynecomastia /??a?n?k??m more...

MalaCards based summary: Gynecomastia is related to peutz-jeghers syndrome and leydig cell tumor. An important gene associated with Gynecomastia is HSD17B3 (hydroxysteroid (17-beta) dehydrogenase 3), and among its related pathways are Androgen Signaling and Steroid hormone biosynthesis. The drugs tamoxifen and tamoxifen citrate and the compounds Androst-5-ene-3b,17b-diol and vorozole have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and skin.

Aliases & Classifications for Gynecomastia

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 38NCIt, 33MeSH
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Gynecomastia, Aliases & Descriptions:

Name: Gynecomastia 9 11 43 60


External Ids:

Disease Ontology9 DOID:12698
NCIt38 C3073
MeSH33 D006177

Related Diseases for Gynecomastia

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Diseases related to Gynecomastia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 160)
idRelated DiseaseScoreTop Affiliating Genes
1peutz-jeghers syndrome30.8CYP19A1, INHA
2leydig cell tumor30.7INHA, CYP19A1
3sertoli cell tumor30.5INHA, CYP19A1
4pseudohermaphroditism30.5CYP19A1, HSD17B3, SRY
5hypogonadism30.5CYP19A1, SHBG
6androgen insensitivity, partial, with or without breast cancer30.5CYP19A1, SHBG
7hypospadias30.4HSD17B3, SRY
8androgen insensitivity30.3SHBG, HSD17B3, SRY
9complete androgen insensitivity syndrome30.2CYP19A1, SHBG
10testicular cancer30.2SHBG, INHA
11breast cancer30.1APOD, SHBG, CYP19A1
12precocious puberty30.0SHBG, CYP19A1
13cryptorchidism30.0SRY, SHBG, CYP19A1
14breast cyst29.8APOD, CYP19A1
15klinefelter's syndrome29.7CYP19A1, INHA, SHBG
16osteoporosis29.7SHBG, CYP19A1
17prostate cancer29.5CYP19A1, INHA, SHBG, HSD17B3, APOD, SRY
18infertility29.4SRY, SHBG, INHA, CYP19A1
19prostatitis10.5
20hermaphroditism10.4SRY
21hypoactive sexual desire disorder10.4SHBG
22pseudohermaphroditism, male, with gynecomastia10.4
23ovarian disease10.3CYP19A1
24aromatase excess syndrome10.3
25spinal and bulbar muscular atrophy of kennedy10.3
26wilson-turner syndrome10.3
27ductal carcinoma in situ10.3
28neurofibromatosis10.3
29obesity10.3
30arthritis10.3
31rheumatoid arthritis10.2
32pseudoangiomatous stromal hyperplasia10.2
33dysgerminoma10.2INHA, SRY
34amenorrhea10.2SHBG, SRY
35turner syndrome10.2SRY, SHBG
36hepatocellular carcinoma10.2
37leukemia10.2
38infant gynecomastia10.2
39premature ovarian failure10.2INHA, SHBG
40alopecia, androgenetic, 110.1SHBG, CYP19A1
41endometrial stromal sarcoma10.1CYP19A1, INHA
42congenital adrenal hyperplasia10.1SRY, CYP19A1
43anovulation10.1CYP19A1, SHBG
44hyperprolactinemia10.1
45borjeson-forssman-lehmann syndrome10.1
46adenoma10.1
47myeloid leukemia10.1
48seminoma10.1
49abrikosov's tumor10.1CYP19A1, INHA
50azoospermia10.1SHBG, SRY

Graphical network of the top 20 diseases related to Gynecomastia:



Diseases related to gynecomastia

Symptoms for Gynecomastia

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Drugs & Therapeutics for Gynecomastia

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Drug clinical trials:

Search ClinicalTrials for Gynecomastia

Search NIH Clinical Center for Gynecomastia

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Gynecomastia

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Anatomical Context for Gynecomastia

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MalaCards organs/tissues related to Gynecomastia:

31
Breast, Prostate, Skin, Lung, Testis, Spinal cord, Liver, Myeloid, Heart, Bone, Thyroid, Pituitary

Animal Models for Gynecomastia or affiliated genes

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Publications for Gynecomastia

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Articles related to Gynecomastia:

(show top 50)    (show all 563)
idTitleAuthorsYear
1
Pseudoangiomatous stromal hyperplasia with multinucleated stromal giant cells is neither exceptional in gynecomastia nor characteristic of neurofibromatosis type 1. (25586494)
2015
2
Can digit ratio (2D:4D) studies be helpful in explaining the aetiology of idiopathic gynecomastia? (25543532)
2015
3
Digital breast tomosynthesis of gynecomastia and associated findings-a pictorial review. (24852677)
2014
4
Clinical and surgical management of unilateral prepubertal gynecomastia. (25437663)
2014
5
Bilateral pseudoangiomatous stromal hyperplasia tumors in axillary male gynecomastia: report of a case. (24676934)
2014
6
Commentary on "gynecomastia: etiologies, clinical presentations, diagnosis, and management". (24389787)
2014
7
Genetic variants of estrogen beta and leptin receptors may cause gynecomastia in adolescent. (24625355)
2014
8
An Aroma of Complexity: How the Unique Genetics of Aromatase (CYP19A1) Explain Diverse Phenotypes From Hens and Hyenas to Human Gynecomastia, and Testicular and Other Tumors. (24311795)
2013
9
Prepubertal gynecomastia in two monozygotic twins with Peutz-Jeghers syndrome: clinical and surgical management. (23968963)
2013
10
18F-FDG PET/CT in detection of gynecomastia in patients with hepatocellular carcinoma. (23809917)
2013
11
A randomized trial comparing tamoxifen therapy vs. tamoxifen prophylaxis in bicalutamide-induced gynecomastia. (22502790)
2012
12
Surgical treatment of gynecomastia: complications and outcomes. (21712702)
2012
13
SRY-positive 46, XY male with vanishing testis syndrome, feminization and gynecomastia. (23441485)
2012
14
Euprolactinemic gynecomastia and galactorrhea with risperidone-fluvoxamine combination. (22506441)
2011
15
Unilateral gynecomastia in a young adult. (21673478)
2011
16
Gynecomastia - a difficult diagnostic problem. (21528484)
2011
17
Fibromatosis of the male breast with concurrent florid-type gynecomastia: Report of a case and review of literature. (21511401)
2011
18
Treatment of adolescent gynecomastia. (20223338)
2010
19
High grade gynecomastia: surgical correction and potential impact on erectile function. (20233285)
2010
20
Gynecomastia, obesity and underdeveloped testis and penis: suspected hypophysitis successfully cured with low dose of cyclosporine A. (19951616)
2009
21
It is reasonable to do endocrine investigation in gynecomastia. (18216522)
2008
22
Leydig cell hyperplasia revealed by gynecomastia. (18660859)
2008
23
Phenotype of patients with gynecomastia]. (18465688)
2008
24
Testicular interstitial cell tumor and gynecomastia in a rabbit. (17606513)
2007
25
Clonidine-induced gynecomastia and hyperprolactinemia in a 6-year-old child. (16401171)
2005
26
Gynecomastia and mucosal lentigines in an 8-year-old boy. (16198789)
2005
27
Sertoli cell tumor causing prepubertal gynecomastia in a boy with peutz-jeghers syndrome: the outcome of 1-year treatment with the aromatase inhibitor testolactone. (15947469)
2005
28
Possible involvement of aromatase overexpression induced by cyclo-oxygenase-2 in the pathogenesis of idiopathic gynecomastia. (16392624)
2005
29
A case-control study of gynecomastia in HIV-1-infected patients receiving HAART. (14959701)
2004
30
Sonography of pediatric male breast masses: gynecomastia and beyond. (15378216)
2004
31
Psychosocial adjustment of two boys with gynecomastia. (15151602)
2004
32
Gynecomastia following chemotherapy for testicular cancer. (12660472)
2003
33
Gynecomastia in male HIV patients MRI and US findings. (12213363)
2002
34
Gynecomastia: complications of the subcutaneous mastectomy. (11842972)
2002
35
Occult Leydig cell tumor in a patient with gynecomastia. (11497478)
2001
36
Isolated relapse of acute lymphoblastic leukemia in the breast masquerading as gynecomastia. (10896624)
2000
37
Treatment of adolescent gynecomastia using a bipedicle technique. (9523606)
1998
38
Gynecomastia following spinal cord disorder. (9161376)
1997
39
Evaluation and treatment of gynecomastia. (9105209)
1997
40
Gynecomastia with metoclopramide use in pediatric patients. (9077721)
1997
41
Prepubertal gynecomastia during growth hormone therapy. (7699552)
1995
42
Case report: finasteride-induced gynecomastia in a 62-year-old man. (7539584)
1995
43
Correction of gynecomastia with an inframammary incision and subsequent scar. (7480316)
1995
44
Nipple placement in simple mastectomy with free nipple grafting for severe gynecomastia. (7972427)
1994
45
Metastatic hepatocellular carcinoma of the breast, simulating gynecomastia: diagnosis by fine-needle aspiration biopsy. (1334827)
1992
46
Mineralocorticoids in the mechanism of gynecomastia in adrenal hyperplasia caused by 11 beta-hydroxylase deficiency. (1993958)
1991
47
Re: Liposuction of giant lipoma and the treatment of gynecomastia without sharp excision. (2029145)
1991
48
The occurrence of gynecomastia upon withdrawal of clomiphene citrate treatment for idiopathic oligospermia. (6773824)
1980
49
Leydig-cell tumor of the testis with gynecomastia and elevated estrogen levels. (868795)
1977
50
Mediastinal seminoma. Associated with exophthalmos and gynecomastia. (4819703)
1974

Variations for Gynecomastia

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Expression for genes affiliated with Gynecomastia

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Search GEO for disease gene expression data for Gynecomastia.

Pathways for genes affiliated with Gynecomastia

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Pathways related to Gynecomastia according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5SRY, SHBG
2
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism36
9.4HSD17B3, CYP19A1
3
Show member pathways
9.4HSD17B3, CYP19A1
4
Show member pathways
Estrogen biosynthesis58
Androstenedione and testosterone biosynthesis and metabolism p.158
9.4HSD17B3, CYP19A1
5
Show member pathways
estradiol biosynthesis II36
androgen biosynthesis36
estradiol biosynthesis I36
progesterone biosynthesis36
9.4HSD17B3, CYP19A1
69.3CYP19A1, INHA

Compounds for genes affiliated with Gynecomastia

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Compounds related to Gynecomastia according to GeneCards Suite gene sharing:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1Androst-5-ene-3b,17b-diol249.9HSD17B3, CYP19A1
2vorozole439.8SHBG, CYP19A1
3formestane439.8CYP19A1, SHBG
4ment439.8CYP19A1, SHBG
5atrazine439.8SHBG, CYP19A1
6androstenediol439.7SHBG, CYP19A1
7carbimazole43 1210.7SHBG, CYP19A1
8nandrolone43 2410.7SHBG, CYP19A1
9goserelin43 28 1211.7SHBG, CYP19A1
10megestrol acetate439.7CYP19A1, SHBG
115alpha-androstane-3alpha,17beta-diol439.7CYP19A1, SHBG
12leuprolide acetate439.7SHBG, CYP19A1
13finasteride43 59 24 1212.7CYP19A1, SHBG
14exemestane43 49 59 1212.7SHBG, CYP19A1
15anastrozole43 49 1211.7SHBG, CYP19A1
16toremifene43 1210.7CYP19A1, SHBG
17naringenin43 1210.7CYP19A1, SHBG
18Testosterone sulfate249.7CYP19A1, HSD17B3
19clomiphene citrate439.7CYP19A1, SHBG
20tibolone439.7SHBG, CYP19A1
21danazol43 24 1211.7SHBG, CYP19A1
22cyproteroneacetate439.7SHBG, CYP19A1
23letrozole43 49 59 1212.6SHBG, CYP19A1
24levonorgestrel43 59 28 1212.6CYP19A1, SHBG
2517-hydroxyprogesterone43 2410.6SHBG, CYP19A1
26flutamide43 59 1211.6SHBG, CYP19A1
27estrone sulfate43 2410.6CYP19A1, SHBG
2825-hydroxyvitamin d439.6SHBG, CYP19A1
2917beta-hydroxysteroid439.6CYP19A1, HSD17B3
30diethylstilbestrol43 28 1211.6SHBG, CYP19A1
313beta-hydroxysteroid439.5INHA, CYP19A1
32ketoconazole43 28 24 1212.5CYP19A1, SHBG
33dehydroepiandrosterone sulfate439.5CYP19A1, SHBG
34biotin43 24 1211.4INHA, SHBG, SRY
35progestins439.4SHBG, CYP19A1
36estrone43 28 24 1212.3HSD17B3, SHBG, CYP19A1
37raloxifene43 49 28 1212.3CYP19A1, SHBG
38progestin439.3SHBG, CYP19A1
39metformin43 49 1211.2SHBG, CYP19A1
40gnrh439.2SHBG, INHA, CYP19A1
41agarose439.1INHA, APOD, SRY
42dhea439.0SHBG, CYP19A1
43androstenedione43 249.9CYP19A1, INHA, SHBG, HSD17B3
44tamoxifen43 49 28 1211.8CYP19A1, SHBG, APOD
45dihydrotestosterone43 28 24 1211.5CYP19A1, SHBG, APOD, SRY
46progesterone43 28 59 24 1212.4CYP19A1, INHA, SHBG, APOD
47estradiol43 24 1210.4SRY, HSD17B3, SHBG, INHA, CYP19A1
48estrogen438.0CYP19A1, INHA, SHBG, HSD17B3, APOD
49steroid438.0SRY, APOD, SHBG, INHA, CYP19A1
50testosterone43 59 24 1210.6SRY, APOD, HSD17B3, SHBG, INHA, CYP19A1

GO Terms for genes affiliated with Gynecomastia

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Biological processes related to Gynecomastia according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1steroid metabolic processGO:00082029.4HSD17B3, CYP19A1

Products for genes affiliated with Gynecomastia

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Sources for Gynecomastia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet