MCID: GYN001
MIFTS: 57

Gynecomastia malady

Summaries for Gynecomastia

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63Wikipedia, 32MalaCards
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Wikipedia:63 Gynecomastia /ˌɡaɪnɨkɵˈmæstiə/ is the benign enlargement of breast tissue in males.[a] It may... more...

MalaCards: Gynecomastia, also known as gynaecomastia, is related to prostatitis and breast cancer. An important gene associated with Gynecomastia is HSD17B3 (hydroxysteroid (17-beta) dehydrogenase 3), and among its related pathways are estrogen biosynthesis and Estrogen biosynthesis. The drugs tamoxifen and tamoxifen citrate and the compounds estrogen and goserelin have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and skin, and related mouse phenotypes are endocrine/exocrine gland and integument.

Aliases & Classifications for Gynecomastia

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Aliases & Descriptions:

gynecomastia 8 10 44 60
gynaecomastia 8


External Ids:

Disease Ontology8 DOID:12698
MeSH34 D006177
NCIt39 C3073

Related Diseases for Gynecomastia

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17GeneCards, 18GeneDecks
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Diseases related to Gynecomastia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 258)
idRelated DiseaseScoreTop Affiliating Genes
1prostatitis30.6SRD5A1, KLK3
2breast cancer30.6BRCA2, BRCA1
3prostate cancer30.6SRD5A1, KLK3
4leydig cell tumor30.4SRD5A1, INHA, CYP17A1, CYP19A1, CGB5, CGA
5pseudohermaphroditism30.4SRD5A2, SRY, CYP17A1, CYP19A1, HSD17B3
6peutz-jeghers syndrome30.4INHA, CYP19A1, BRCA2
7ductal carcinoma in situ30.3ESR1, PGR, BRCA2, BRCA1
8hypogonadism30.3CYP19A1, SHBG, PRL, CGB5, CGA, GNRH1
9obesity30.3SRD5A1, INHA, NR3C2, SHBG
10male breast cancer30.3ESR1, PGR, APOD, BRCA2, BRCA1
11sertoli cell tumor30.1PGR, INHA, CYP19A1
12leukemia30.1NR3C2, BRCA2, BRCA1
13hepatocellular carcinoma30.1SRD5A2, CYP17A1, SHBG, APOD, BRCA2
14aromatase excess syndrome30.1CYP19A1
15hyperprolactinemia30.0SRD5A1, SHBG, PRL, CGB5, CGA, GNRH1
16adenoma30.0SRD5A1, INHA, CYP17A1, NR3C2, SHBG, PRL
17partial androgen insensitivity syndrome29.9SRD5A1, CYP19A1, SHBG
18seminoma29.9INHA, CGB5, CGA
19testicular cancer29.9INHA, SHBG, CGB5, CGA
20varicocele29.9SHBG, PRL, CGA, GNRH1
21impotence29.9SRD5A1, SHBG, PRL, KLK3
22hypothyroidism29.9SHBG, PRL, CGA, GNRH1
23prolactinoma29.9ESR1, PRL, CGA, GNRH1
24bilateral breast cancer29.9ESR1, PGR, BRCA2, BRCA1
25androgen insensitivity syndrome29.9SRD5A2, SRD5A1, SRY, SHBG, CGA, HSD17B3
26hypospadias29.9SRD5A2, SRD5A1, SRY, CYP17A1, CGA, HSD17B3
27graves' disease29.9SHBG, CGA
28cryptorchidism29.9SRD5A1, SRY, CYP19A1, SHBG, CGB5, CGA
29adenocarcinoma29.9ESR1, SRD5A1, PGR, INHA, CGB5, BRCA2
30hermaphroditism29.7SRY
31thyroiditis29.7CGA
32aromatase deficiency29.7CYP19A1
33hypertension29.7CYP17A1, NR3C2
34sarcoma29.7CGB5, BRCA2
35breast fibroadenoma29.7ESR1, PGR
36adrenal adenoma29.7INHA, CYP17A1, CYP19A1
37breast cyst29.7CYP19A1, CGB5, APOD, KLK3
38sexual disorder29.7SHBG, PRL, GNRH1, KLK3
39pituitary adenoma29.7INHA, PRL, CGA, GNRH1
40congenital adrenal hyperplasia29.7SRD5A1, SRY, CYP17A1, CYP19A1, GNRH1
41oligospermia29.7SRD5A1, PRL, CGB5, CGA, GNRH1
42hyperthyroidism29.7SRD5A1, SHBG, PRL, CGB5, CGA
43leiomyoma29.7ESR1, PGR, CYP17A1, CYP19A1, GNRH1
44transitional cell carcinoma29.7SRD5A1, CGB5, KLK3
45klinefelter's syndrome29.7SRD5A1, INHA, CYP19A1, SHBG, PRL, CGA
46in situ carcinoma10.2
47infant gynecomastia10.2
48arthritis10.2
49rheumatoid arthritis10.2
50x-linked spinal-bulbar muscle atrophy10.2

Graphical network of the top 20 diseases related to Gynecomastia:



Diseases related to gynecomastia

Clinical Features for Gynecomastia

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Drugs & Therapeutics for Gynecomastia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Gynecomastia

Drug clinical trials:

Search ClinicalTrials for Gynecomastia

Search NIH Clinical Center for Gynecomastia

Search CenterWatch for Gynecomastia

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Gynecomastia

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Anatomical Context for Gynecomastia

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32MalaCards
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MalaCards organs/tissues related to Gynecomastia:

32
Breast, Prostate, Skin, Lung, Testis, Myeloid, Spinal cord, Liver, Heart, Thyroid, Pituitary

Animal Models for Gynecomastia or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Gynecomastia:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053799.8BRCA1, BRCA2, INHA, SRY, SRD5A1, SRD5A2
2MP:00107719.8BRCA1, BRCA2, GNRH1
3MP:00020069.6BRCA1, BRCA2, GNRH1, PRL, INHA, PGR
4MP:00053899.5SRD5A2, BRCA1, BRCA2, GNRH1, CGA, PRL
5MP:00053909.5BRCA1, BRCA2, GNRH1, CYP19A1, INHA, PGR
6MP:00036319.3BRCA2, GNRH1, APOD, CGA, PRL, NR3C2
7MP:00053869.3BRCA1, BRCA2, APOD, PRL, NR3C2, CYP19A1
8MP:00053769.0BRCA1, BRCA2, GNRH1, APOD, CGA, PRL

Publications for Gynecomastia

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50PubMed
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Articles related to Gynecomastia:

(show top 50)    (show all 530)
idTitleAuthorsYear
1
Commentary on "gynecomastia: etiologies, clinical presentations, diagnosis, and management". (24389787)
2014
2
Incremental clinical value of ultrasound in men with mammographically confirmed gynecomastia. (24161780)
2014
3
18F-FDG PET/CT in detection of gynecomastia in patients with hepatocellular carcinoma. (23809917)
2013
4
Endoscopic subcutaneous mastectomy: A novel and effective treatment for gynecomastia. (23837054)
2013
5
SRY-positive 46, XY male with vanishing testis syndrome, feminization and gynecomastia. (23441485)
2012
6
The 3-layered ductal epithelium in gynecomastia. (22314184)
2012
7
Statin-associated gynecomastia: evidence coming from the Italian spontaneous ADR reporting database and literature. (22286160)
2012
8
The efficacy of tamoxifen in the treatment of primary gynecomastia: an observational study of tamoxifen versus observation alone. (23078360)
2012
9
Gynecomastia - a difficult diagnostic problem. (21528484)
2011
10
Incidental finding of synchronous bilateral ductal carcinoma in situ associated with gynecomastia in a 15-year-old obese boy: case report and review of the literature. (21929970)
2011
11
Unilateral and painless development of isoniazid induced gynecomastia during re-treatment of pulmonary tuberculosis. (22616343)
2011
12
Bilateral DCIS following gynecomastia surgery. Role of nipple sparing mastectomy. A case report and review of literature. (22096697)
2011
13
Leydig cell tumour revealed by bilateral gynecomastia in a 15-year-old adolescent: a patient report. (21284336)
2010
14
Evaluation of breast enlargement in young males and factors associated with gynecomastia and pseudogynecomastia. (19495841)
2010
15
A case of gynecomastia due to entecavir. (20931440)
2010
16
11-Hydroxylase deficiency as a cause of pre-pubertal gynecomastia. (19636210)
2009
17
An unusual case of gynecomastia associated with soy product consumption. (18558591)
2008
18
Gynecomastia in adolescents. (18622190)
2008
19
Prepubertal gynecomastia linked to lavender and tea tree oils. (17575591)
2007
20
Worsening of motor symptoms and gynecomastia during spironolactone treatment in a patient with Parkinson's disease and congestive heart failure. (17534964)
2007
21
Gynecomastia and mucosal lentigines in an 8-year-old boy. (16198789)
2005
22
Multimodality gynecomastia repair by cross-chest power-assisted superficial liposuction combined with endoscopic-assisted pull-through excision. (16327457)
2005
23
Treatment of adolescents with gynecomastia. (15812473)
2005
24
Aromatase-dependent gynecomastia in a patient with adenocarcinoma of the lung]. (16238933)
2005
25
Periareolar-transareolar-perithelial incision for the surgical treatment of gynecomastia. (15655460)
2005
26
A possible case of gynecomastia with fluoxetine. (15956241)
2005
27
Efavirenz-associated gynecomastia: report of five cases and review of the literature. (15125753)
2004
28
Gynecomastia treatment with subareolar glandular pedicle. Discussion, 287. (15666043)
2004
29
Gynecomastia and potent antiretroviral therapy. (15362673)
2004
30
Gynecomastia in HIV-infected patients receiving antiretroviral therapy. (14585204)
2003
31
Neonatal gynecomastia visualized during Tc-99m pertechnetate thyroid scintigraphy. (14663325)
2003
32
An elderly case of advanced gastric cancer with gynecomastia and high serum levels of hCG]. (12404754)
2002
33
Successful percutaneous dihydrotestosterone treatment of gynecomastia occurring during highly active antiretroviral therapy: four cases and a review of the literature. (11512095)
2001
34
Cytologic atypia in a 53-year-old man with finasteride-induced gynecomastia. (10747325)
2000
35
Moclobemide-induced gynecomastia in rats. (11501039)
2000
36
Gynecomastia-like lesions in the female breast. (10835518)
2000
37
Acute myeloid leukemia relapsing as gynecomastia. (10613464)
1999
38
Giant retroperitoneal hemangiopericytoma with paraneoplastic gynecomastia. Case report and literature review. (10567888)
1999
39
Gynecomastia as the initial manifestation of hyperthyroidism. (15251481)
1997
40
Apocrine metaplasia in gynecomastia by fine needle aspiration as a possible indicator of anabolic steroid use. A report of two cases. (8693895)
1996
41
Case report: finasteride-induced gynecomastia in a 62-year-old man. (7539584)
1995
42
Clinical studies on changes in sexual hormones and estrogen receptor in patients with gynecomastia]. (8706561)
1995
43
Gynecomastia with unusual intraductal "clear cell" changes mimicking pagetoid ductal spread of lobular neoplasia. (7567685)
1995
44
Gynecomastia associated with enalapril and diazepam. (8069010)
1994
45
Another cause of gynecomastia. (8144721)
1994
46
Gynecomastia. (8515797)
1993
47
Tamoxifen therapy for painful idiopathic gynecomastia. (2237557)
1990
48
Unilateral gynecomastia associated with thoracotomy following resection of carcinoma of the lung. (2596496)
1989
49
Male pseudohermaphroditism due to 17-ketoreductase deficiency: report of a case without gynecomastia and without vaginal pouch. (3004217)
1986
50
Male breast cancer. 4. Gynecomastia in patients with breast cancer. (4767228)
1973

Genetic Variations for Gynecomastia

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Expression for genes affiliated with Gynecomastia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Gynecomastia

Search GEO for disease gene expression data for Gynecomastia.

Pathways for genes affiliated with Gynecomastia

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Sources:
37NCBI BioSystems Database, 53Reactome, 49PharmGKB, 12EMD Millipore, 29KEGG
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Pathways related to Gynecomastia according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3HSD17B3, CYP19A1
2
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10.2CYP19A1, ESR1
3
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10.2CGA, GNRH1
4
Estrone metabolism
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10.2CYP17A1, CYP19A1, HSD17B3
510.1CYP17A1, CYP19A1, CGA
610.1CYP19A1, INHA, PGR
7
Transcription Androgen Receptor nuclear signaling
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10.1SRD5A2, SRD5A1, KLK3
810.0ESR1, BRCA1, KLK3
9
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10.0NR3C2, PGR, ESR1
10
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10.0KLK3, HSD17B3, BRCA1, CYP17A1
11
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10.0HSD17B3, CYP17A1, SRD5A1, SRD5A2
12
Development Prolactin receptor signaling
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9.9ESR1, CYP17A1, PRL, CGA
13
Hide members
9.9SRD5A2, BRCA2, BRCA1, KLK3
149.9BRCA1, BRCA2, CYP19A1, ESR1
15
Hide members
9.9SRD5A2, SRD5A1, CYP17A1, CYP19A1, HSD17B3

Compounds for genes affiliated with Gynecomastia

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Gynecomastia according to GeneCards/GeneDecks:

(show top 50)    (show all 221)
idCompoundScoreTop Affiliating Genes
1estrogen4410.5KLK3, SRD5A1
2goserelin44 28 1112.4CGA, GNRH1, SRD5A1
3ment4410.2ESR1, CYP19A1, SHBG, KLK3, SRD5A1
4cycloheximide4410.1KLK3, BRCA2, BRCA1, CGB5
511 deoxycortisol4410.1SHBG, PRL, CGA, NR3C2, CYP17A1
6toremifene44 1111.0ESR1, PGR, PRL, GNRH1, SHBG, CYP19A1
7danazol44 11 2412.0GNRH1, PGR, PRL, SHBG, CYP19A1, ESR1
8letrozole44 49 59 1113.0SHBG, CYP17A1, ESR1, PGR, CYP19A1, CGA
9cyproteroneacetate4410.0KLK3, GNRH1, PRL, SHBG, CYP19A1, PGR
10exemestane49 44 59 1113.0ESR1, SRD5A1, PGR, CYP19A1, SHBG, CYP17A1
11megestrol acetate4410.0KLK3, SHBG, PGR, CYP19A1, ESR1
12leuprolide44 59 28 1113.0GNRH1, SRD5A1, CGB5, PRL, KLK3, CGA
13anastrozole44 1111.0SHBG, CYP19A1, PGR, CGA, ESR1
14buserelin44 28 1112.0GNRH1, CGA, CGB5, PRL, CYP19A1, PGR
15estrone sulfate44 2411.0PRL, ESR1, PGR, CYP17A1, CYP19A1, SHBG
16levonorgestrel44 59 28 1113.0CYP19A1, ESR1, SRD5A1, PGR, PRL, SHBG
17aminoglutethimide44 1111.0KLK3, CGB5, CYP19A1, ESR1, NR3C2
18estradiol benzoate449.9PGR, ESR1, CYP19A1, PRL, CGB5, GNRH1
19spironolactone49 44 59 28 1113.9SRD5A1, KLK3, PGR, GNRH1, SHBG, NR3C2
20hydroxyflutamide44 2810.9KLK3, SRD5A1, ESR1, SHBG, CGA
21steroidal449.8SRD5A1, ESR1, CYP17A1, CYP19A1, NR3C2, GNRH1
2217-hydroxyprogesterone44 2410.8GNRH1, CGA, CGB5, PRL, SHBG, CYP19A1
23tibolone449.8GNRH1, CYP19A1, PGR, ESR1, SHBG
24clomiphene citrate449.8GNRH1, CGA, CGB5, PRL, SHBG, CYP19A1
25progestins449.8KLK3, GNRH1, SHBG, NR3C2, CYP19A1, PGR
26dhea449.7PRL, CGB5, KLK3, SHBG, CYP19A1, CYP17A1
27finasteride44 59 11 2412.7SHBG, KLK3, SRD5A2, SRD5A1, CYP19A1
28flutamide44 59 1111.7ESR1, SRD5A1, PGR, CYP19A1, KLK3, GNRH1
29leuprolide acetate449.7ESR1, PGR, CYP19A1, KLK3, GNRH1, CGA
30dehydroepiandrosterone sulfate449.7GNRH1, CGA, CGB5, PRL, CYP17A1, SRD5A1
31diethylstilbestrol44 28 1111.7KLK3, GNRH1, CGA, CGB5, SHBG, CYP19A1
323beta-hydroxysteroid449.7CGA, CGB5, NR3C2, CYP19A1, CYP17A1, INHA
33mifepristone44 59 28 1112.7PGR, ESR1, CYP19A1, NR3C2, SHBG, GNRH1
34formestane449.6SHBG, CYP19A1, SRD5A1, ESR1
35estrone44 28 11 2412.6ESR1, CYP17A1, SRD5A1, HSD17B3, GNRH1, CGB5
36ribonucleic acid449.6NR3C2, GNRH1, CGA, CGB5, CYP17A1, SRD5A2
37vitamin d449.6SRD5A1, SRD5A2, SHBG, KLK3, CYP17A1, CGA
38androstenedione44 2410.6HSD17B3, GNRH1, CGA, CGB5, PRL, SHBG
3917beta-hydroxysteroid449.5HSD17B3, BRCA1, CGA, CGB5, CYP19A1, CYP17A1
40progestin449.4GNRH1, CGA, CGB5, PRL, SHBG, NR3C2
41gnrh449.3KLK3, GNRH1, CGA, CGB5, PRL, SHBG
42paraffin449.3CGA, ESR1, PGR, CGB5, APOD, BRCA2
43tamoxifen44 49 28 1112.3CGA, PGR, CYP17A1, CYP19A1, SHBG, CGB5
44genistein44 28 59 2 11 2414.2BRCA2, BRCA1, ESR1, CGB5, CYP17A1, SRD5A1
45retinoic acid44 2410.1SHBG, NR3C2, SRD5A1, CYP17A1, CYP19A1, PGR
46dihydrotestosterone44 28 11 2411.9KLK3, GNRH1, APOD, CGA, CGB5, PRL
47progesterone44 59 28 11 2412.7BRCA1, CYP19A1, NR3C2, SHBG, PRL, CGB5
48estradiol44 11 2410.5SHBG, NR3C2, CYP19A1, CYP17A1, INHA, PGR
49steroid448.5KLK3, BRCA1, BRCA2, GNRH1, APOD, SRY
50testosterone44 59 11 2411.4KLK3, HSD17B3, BRCA1, BRCA2, GNRH1, APOD

GO Terms for genes affiliated with Gynecomastia

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16Gene Ontology
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Cellular components related to Gynecomastia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.6GNRH1, APOD, CGA, PRL, SHBG, INHA
2endoplasmic reticulum membraneGO:0057899.4SRD5A2, SRD5A1, CYP17A1, CYP19A1, NR3C2, HSD17B3

Biological processes related to Gynecomastia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1androgen metabolic processGO:00820910.2ESR1, SRD5A2, CYP19A1
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.2BRCA2, BRCA1
3androgen biosynthetic processGO:00670210.1SRD5A2, SRD5A1, CYP17A1, HSD17B3
4ovulation cycleGO:04269810.1GNRH1, PRL
5male gonad developmentGO:00858410.1INHA, SRY, SRD5A2, ESR1
6steroid metabolic processGO:00820210.0HSD17B3, CYP19A1, CYP17A1, SRD5A1, SRD5A2
7cell-cell signalingGO:0072679.9SRD5A2, PGR, INHA, CGA, GNRH1
8signal transductionGO:0071659.3ESR1, PGR, INHA, NR3C2, CGA, GNRH1

Molecular functions related to Gynecomastia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholestenone 5-alpha-reductase activityGO:04775110.1SRD5A1, SRD5A2
2hormone activityGO:00517910.1INHA, PRL, CGA, GNRH1
3steroid bindingGO:00549610.0ESR1, PGR, NR3C2
4steroid hormone receptor activityGO:00370710.0ESR1, PGR, NR3C2
53-oxo-5-alpha-steroid 4-dehydrogenase activityGO:0038659.9SRD5A1, SRD5A2

Products for genes affiliated with Gynecomastia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gynecomastia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet