MCID: GYN001
MIFTS: 56

Gynecomastia malady

Summaries for Gynecomastia

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Gynecomastia /ˌɡaɪnɨkɵˈmæstiə/ is the benign enlargement of breast tissue in males.[a] It may... more...

MalaCards: Gynecomastia, also known as gynaecomastia, is related to peutz-jeghers syndrome and male breast cancer. An important gene associated with Gynecomastia is HSD17B3 (hydroxysteroid (17-beta) dehydrogenase 3), and among its related pathways are estrogen biosynthesis and Estrogen biosynthesis. The drugs tamoxifen and tamoxifen citrate and the compounds estrogen and goserelin have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, heart and liver, and related mouse phenotypes are endocrine/exocrine gland and integument.

Aliases & Classifications for Gynecomastia

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Aliases & Descriptions:

gynecomastia 8 10 45 61
gynaecomastia 8


External Ids:

Disease Ontology8 DOID:12698
MeSH35 D006177
NCIt40 C3073

Related Diseases for Gynecomastia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Gynecomastia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 251)
idRelated DiseaseScoreTop Affiliating Genes
1peutz-jeghers syndrome30.4INHA, CYP19A1, BRCA2
2male breast cancer30.3ESR1, PGR, APOD, BRCA2, BRCA1
3sertoli cell tumor30.2PGR, INHA, CYP19A1
4aromatase excess syndrome30.1CYP19A1
5ductal carcinoma in situ30.1ESR1, PGR, BRCA2, BRCA1
6hyperprolactinemia30.1SRD5A1, SHBG, PRL, CGB5, CGA, GNRH1
7adenoma30.1SRD5A1, INHA, CYP17A1, NR3C2, SHBG, PRL
8partial androgen insensitivity syndrome30.0SRD5A1, CYP19A1, SHBG
9testicular cancer30.0INHA, SHBG, CGB5, CGA
10varicocele30.0SHBG, PRL, CGA, GNRH1
11prolactinoma30.0ESR1, PRL, CGA, GNRH1
12bilateral breast cancer30.0ESR1, PGR, BRCA2, BRCA1
13short stature30.0SRY, CYP19A1, SHBG, PRL, GNRH1
14androgen insensitivity syndrome30.0SRD5A2, SRD5A1, SRY, SHBG, CGA, HSD17B3
15hypospadias30.0SRD5A2, SRD5A1, SRY, CYP17A1, CGA, HSD17B3
16graves' disease30.0SHBG, CGA
17adenocarcinoma30.0ESR1, SRD5A1, PGR, INHA, CGB5, BRCA2
18aromatase deficiency29.7CYP19A1
19adrenal adenoma29.7INHA, CYP17A1, CYP19A1
20congenital adrenal hyperplasia29.7SRD5A1, SRY, CYP17A1, CYP19A1, GNRH1
21oligospermia29.7SRD5A1, PRL, CGB5, CGA, GNRH1
22precocious puberty29.7CYP19A1, SHBG, PRL, CGB5, CGA, GNRH1
23transitional cell carcinoma29.7SRD5A1, CGB5, KLK3
24cryptorchidism29.7SRD5A1, SRY, CYP19A1, SHBG, CGB5, CGA
25klinefelter's syndrome29.7SRD5A1, INHA, CYP19A1, SHBG, PRL, CGA
26infant gynecomastia10.3
27peutz–jeghers syndrome10.3
28arthritis10.2
29x-linked spinal-bulbar muscle atrophy10.2
30neurofibromatosis10.1
3117-beta hydroxysteroid dehydrogenase 3 deficiency10.1
32pseudoangiomatous stromal hyperplasia10.1
33mental retardation gynecomastia obesity x-linked10.1
34gastrointestinal stromal tumor10.0
35chronic myeloid leukemia10.0
36acute leukemia10.0
37tuberculosis10.0
38hemophilia10.0
39diabetic mastopathy10.0
40mental retardation10.0
41wilson-turner syndrome10.0
42hermaphroditism10.0SRY
43gonadal dysgenesis10.0SRY
44alopecia10.0SHBG
45growth hormone deficiency10.0PRL
46thyroiditis10.0CGA
47epithelioid trophoblastic tumor10.0INHA
48acne10.0SHBG
49systemic lupus erythematosus10.0PRL
50multiple endocrine neoplasia10.0BRCA2

Graphical network of the top 20 diseases related to Gynecomastia:



Diseases related to gynecomastia

Clinical Features for Gynecomastia

Drugs & Therapeutics for Gynecomastia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gynecomastia

Drug clinical trials:

Search ClinicalTrials for Gynecomastia

Search NIH Clinical Center for Gynecomastia

Search CenterWatch for Gynecomastia

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Gynecomastia

Anatomical Context for Gynecomastia

Sources:
33MalaCards
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MalaCards organs/tissues related to Gynecomastia:

33
Spinal cord, Heart, Liver, Lung, Thyroid, Adrenal gland, Breast, Skin, Prostate, Testis, Myeloid, B lymphoblasts, B cells, Pituitary, Testis germ, Testis leydig

Animal Models for Gynecomastia or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Gynecomastia

Sources:
51PubMed
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Articles related to Gynecomastia:

(show top 50)    (show all 530)
idTitleAuthorsYear
1
Prepubertal gynecomastia in two monozygotic twins with Peutz-Jeghers syndrome: clinical and surgical management. (23968963)
2013
2
Pathological Findings in Gynecomastia: Analysis of 5113 Breasts. (23788148)
2013
3
Assessment of color Doppler ultrasonography findings in gynecomastia. (24286092)
2013
4
A randomized trial comparing tamoxifen therapy vs. tamoxifen prophylaxis in bicalutamide-induced gynecomastia. (22502790)
2012
5
Unilateral gynecomastia in a prepubertal boy. (21894543)
2012
6
Imatinib-associated bilateral gynecomastia and unilateral testicular hydrocele in male patient with metastatic gastrointestinal stromal tumor: a literature review. (22009701)
2012
7
Breast reshaping in gynecomastia by the "pull-through technique": considerations after 15A years. (22593626)
2012
8
Surgical correction of gynecomastia in thin patients. (21072515)
2011
9
Patient information page. Gynecomastia. (21260969)
2011
10
Gynecomastia as a first clinical sign of nonseminomatous germ cell tumor. (21625076)
2011
11
Management of senescent gynecomastia in the Veterans Health Administration. (21410583)
2011
12
Gynecomastia - evaluation and current treatment options. (21479145)
2011
13
Plasma phthalate levels in pubertal gynecomastia. (20008419)
2010
14
Pleomorphic carcinoma of the lung with high serum beta-human chorionic gonadotropin level and gynecomastia. (21165299)
2010
15
Sonographic features of gynecomastia. (20375373)
2010
16
Finasteride induced Gynecomastia: Case report and Review of the Literature. (20805972)
2009
17
Venlafaxine-induced gynecomastia in a young patient: a case report. (18978497)
2009
18
A 16-year-old male with gynecomastia and ductal carcinoma in situ. (18766353)
2008
19
Childhood gynecomastia: a clinical analysis of 240 cases. (17937844)
2007
20
Marinol-induced gynecomastia: a case report. (17904434)
2007
21
Incidence and management of gynecomastia in men treated for prostate cancer. (16217274)
2005
22
Prepubertal gynecomastia with lobular differentiation. (15647078)
2005
23
Dominant transmission of prepubertal gynecomastia due to serum estrone excess: hormonal, biochemical, and genetic analysis in a large kindred. (15483104)
2005
24
Minimal invasive surgery for gynecomastia - A novel approach. (24115887)
2004
25
Gynecomastia and antihypertensive therapy. (15308889)
2004
26
Does prophylactic breast irradiation prevent antiandrogen-induced gynecomastia? Evaluation of 253 patients in the randomized Scandinavian trial SPCG-7/SFUO-3. (12559286)
2003
27
Combined use of ultrasonic liposuction with the pull-through technique for the treatment of gynecomastia. (12960873)
2003
28
Does prophylactic breast irradiation prevent antiandrogen-induced gynecomastia? Evaluation of 253 patients in the randomized Scandinavian trial SPCG-7/SFUO-3. (14567314)
2003
29
Gynecomastia in a patient with celiac disease. (11822574)
2002
30
Gynecomastia in a patient with lung cancer. (10561237)
1999
31
The pinwheel technique: an adjunct to the periareolar approach in gynecomastia resection. (10340852)
1999
32
Tc-99m sestamibi uptake in a patient with gynecomastia: a potential pitfall in the diagnosis of breast cancer. (10361957)
1999
33
Eccentric skin resection and purse-string closure for skin reduction with mastectomy for gynecomastia. (9788217)
1998
34
Tamoxifen as treatment for gynecomastia and mastodynia resulting from hormonal deprivation. (9507867)
1998
35
Finasteride induced gynecomastia. (9224349)
1997
36
Prepubertal gynecomastia during growth hormone therapy. (7699552)
1995
37
Urologic causes of gynecomastia: approach to diagnosis and management. (7855981)
1995
38
Nipple placement in simple mastectomy with free nipple grafting for severe gynecomastia. (7972427)
1994
39
Gynecomastia. (7705322)
1994
40
Malignant granulosa cell tumor of the testis associated with gynecomastia and long survival. (1551061)
1992
41
Holiday gynecomastia. (1567108)
1992
42
Mineralocorticoids in the mechanism of gynecomastia in adrenal hyperplasia caused by 11 beta-hydroxylase deficiency. (1993958)
1991
43
Clozapine as an alternative treatment for neuroleptic-induced gynecomastia. (1671543)
1991
44
New X-linked syndrome of mental retardation, gynecomastia, and obesity is linked to DXS255. (1746601)
1991
45
A new suction-assisted device for removing glandular gynecomastia. (1989036)
1991
46
Epithelial atypia in gynecomastia induced by chemotherapeutic drugs. A possible pitfall in fine needle aspiration biopsy. (1709324)
1991
47
Gynecomastia: a continuing diagnostic dilemma. (1986293)
1991
48
Pelvic sarcoma causing gynecomastia. (2329588)
1990
49
The occurrence of gynecomastia upon withdrawal of clomiphene citrate treatment for idiopathic oligospermia. (6773824)
1980
50
Gynecomastia with congenital virilizing adrenal hyperplasia (11-beta-hydroxylase deficiency). (123956)
1975

Genetic Variations for Gynecomastia

Expression for genes affiliated with Gynecomastia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gynecomastia

Search GEO for disease gene expression data for Gynecomastia.

Pathways for genes affiliated with Gynecomastia

Sources:
38NCBI BioSystems Database, 54Reactome, 50PharmGKB, 12EMD Millipore, 30KEGG
See all sources

Pathways related to Gynecomastia according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3HSD17B3, CYP19A1
2
Hide members
10.2CYP19A1, ESR1
3
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10.2CGA, GNRH1
4
Estrone metabolism
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10.2CYP17A1, CYP19A1, HSD17B3
510.1CYP17A1, CYP19A1, CGA
610.1CYP19A1, INHA, PGR
7
Transcription Androgen Receptor nuclear signaling
Hide members
10.1SRD5A2, SRD5A1, KLK3
810.0ESR1, BRCA1, KLK3
9
Hide members
10.0NR3C2, PGR, ESR1
10
Hide members
10.0KLK3, HSD17B3, BRCA1, CYP17A1
11
Hide members
10.0HSD17B3, CYP17A1, SRD5A1, SRD5A2
12
Development Prolactin receptor signaling
Hide members
9.9ESR1, CYP17A1, PRL, CGA
13
Hide members
9.9SRD5A2, BRCA2, BRCA1, KLK3
149.9BRCA1, BRCA2, CYP19A1, ESR1
15
Hide members
9.9SRD5A2, SRD5A1, CYP17A1, CYP19A1, HSD17B3

Compounds for genes affiliated with Gynecomastia

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
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Compounds related to Gynecomastia according to GeneCards/GeneDecks:

(show top 50)    (show all 221)
idCompoundScoreTop Affiliating Genes
1estrogen4510.5KLK3, SRD5A1
2goserelin45 29 1112.4CGA, GNRH1, SRD5A1
3ment4510.2ESR1, CYP19A1, SHBG, KLK3, SRD5A1
4cycloheximide4510.1KLK3, BRCA2, BRCA1, CGB5
511 deoxycortisol4510.1SHBG, PRL, CGA, NR3C2, CYP17A1
6toremifene45 1111.0ESR1, PGR, PRL, GNRH1, SHBG, CYP19A1
7danazol45 11 2412.0GNRH1, PGR, PRL, SHBG, CYP19A1, ESR1
8letrozole45 50 60 1113.0SHBG, CYP17A1, ESR1, PGR, CYP19A1, CGA
9cyproteroneacetate4510.0KLK3, GNRH1, PRL, SHBG, CYP19A1, PGR
10exemestane50 45 60 1113.0ESR1, SRD5A1, PGR, CYP19A1, SHBG, CYP17A1
11megestrol acetate4510.0KLK3, SHBG, PGR, CYP19A1, ESR1
12leuprolide45 60 29 1113.0GNRH1, SRD5A1, CGB5, PRL, KLK3, CGA
13anastrozole45 1111.0SHBG, CYP19A1, PGR, CGA, ESR1
14buserelin45 29 1112.0GNRH1, CGA, CGB5, PRL, CYP19A1, PGR
15estrone sulfate45 2411.0PRL, ESR1, PGR, CYP17A1, CYP19A1, SHBG
16levonorgestrel45 60 29 1113.0CYP19A1, ESR1, SRD5A1, PGR, PRL, SHBG
17aminoglutethimide45 1111.0KLK3, CGB5, CYP19A1, ESR1, NR3C2
18estradiol benzoate459.9PGR, ESR1, CYP19A1, PRL, CGB5, GNRH1
19spironolactone50 45 60 29 1113.9SRD5A1, KLK3, PGR, GNRH1, SHBG, NR3C2
20hydroxyflutamide45 2910.9KLK3, SRD5A1, ESR1, SHBG, CGA
21steroidal459.8SRD5A1, ESR1, CYP17A1, CYP19A1, NR3C2, GNRH1
2217-hydroxyprogesterone45 2410.8GNRH1, CGA, CGB5, PRL, SHBG, CYP19A1
23tibolone459.8GNRH1, CYP19A1, PGR, ESR1, SHBG
24clomiphene citrate459.8GNRH1, CGA, CGB5, PRL, SHBG, CYP19A1
25progestins459.8KLK3, GNRH1, SHBG, NR3C2, CYP19A1, PGR
26dhea459.7PRL, CGB5, KLK3, SHBG, CYP19A1, CYP17A1
27finasteride45 60 11 2412.7SHBG, KLK3, SRD5A2, SRD5A1, CYP19A1
28flutamide45 60 1111.7ESR1, SRD5A1, PGR, CYP19A1, KLK3, GNRH1
29leuprolide acetate459.7ESR1, PGR, CYP19A1, KLK3, GNRH1, CGA
30dehydroepiandrosterone sulfate459.7GNRH1, CGA, CGB5, PRL, CYP17A1, SRD5A1
31diethylstilbestrol45 29 1111.7KLK3, GNRH1, CGA, CGB5, SHBG, CYP19A1
323beta-hydroxysteroid459.7CGA, CGB5, NR3C2, CYP19A1, CYP17A1, INHA
33mifepristone45 60 29 1112.7PGR, ESR1, CYP19A1, NR3C2, SHBG, GNRH1
34formestane459.6SHBG, CYP19A1, SRD5A1, ESR1
35estrone45 29 11 2412.6ESR1, CYP17A1, SRD5A1, HSD17B3, GNRH1, CGB5
36ribonucleic acid459.6NR3C2, GNRH1, CGA, CGB5, CYP17A1, SRD5A2
37vitamin d459.6SRD5A1, SRD5A2, SHBG, KLK3, CYP17A1, CGA
38androstenedione45 2410.6HSD17B3, GNRH1, CGA, CGB5, PRL, SHBG
3917beta-hydroxysteroid459.5HSD17B3, BRCA1, CGA, CGB5, CYP19A1, CYP17A1
40progestin459.4GNRH1, CGA, CGB5, PRL, SHBG, NR3C2
41gnrh459.3KLK3, GNRH1, CGA, CGB5, PRL, SHBG
42paraffin459.3CGA, ESR1, PGR, CGB5, APOD, BRCA2
43tamoxifen45 50 29 1112.3CGA, PGR, CYP17A1, CYP19A1, SHBG, CGB5
44genistein45 29 60 2 11 2414.2BRCA2, BRCA1, ESR1, CGB5, CYP17A1, SRD5A1
45retinoic acid45 2410.1SHBG, NR3C2, SRD5A1, CYP17A1, CYP19A1, PGR
46dihydrotestosterone45 29 11 2411.9KLK3, GNRH1, APOD, CGA, CGB5, PRL
47progesterone45 60 29 11 2412.7BRCA1, CYP19A1, NR3C2, SHBG, PRL, CGB5
48estradiol45 11 2410.5SHBG, NR3C2, CYP19A1, CYP17A1, INHA, PGR
49steroid458.5KLK3, BRCA1, BRCA2, GNRH1, APOD, SRY
50testosterone45 60 11 2411.4KLK3, HSD17B3, BRCA1, BRCA2, GNRH1, APOD

GO Terms for genes affiliated with Gynecomastia

Sources:
16Gene Ontology
See all sources

Cellular components related to Gynecomastia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.6KLK3, GNRH1, APOD, CGA, PRL, SHBG
2endoplasmic reticulum membraneGO:0057899.4HSD17B3, NR3C2, CYP19A1, CYP17A1, SRD5A1, SRD5A2

Biological processes related to Gynecomastia according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1androgen metabolic processGO:00820910.2SRD5A2, ESR1, CYP19A1
2DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.2BRCA1, BRCA2
3androgen biosynthetic processGO:00670210.1SRD5A2, SRD5A1, CYP17A1, HSD17B3
4ovulation cycleGO:04269810.1PRL, GNRH1
5male gonad developmentGO:00858410.1ESR1, SRD5A2, SRY, INHA
6steroid metabolic processGO:00820210.0SRD5A1, CYP17A1, CYP19A1, HSD17B3, SRD5A2
7cell-cell signalingGO:0072679.9GNRH1, CGA, INHA, PGR, SRD5A2
8signal transductionGO:0071659.3NR3C2, CGA, PGR, ESR1, GNRH1, INHA

Molecular functions related to Gynecomastia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholestenone 5-alpha-reductase activityGO:04775110.1SRD5A2, SRD5A1
2hormone activityGO:00517910.1CGA, INHA, PRL, GNRH1
3steroid bindingGO:00549610.0NR3C2, PGR, ESR1
4steroid hormone receptor activityGO:00370710.0NR3C2, PGR, ESR1
53-oxo-5-alpha-steroid 4-dehydrogenase activityGO:0038659.9SRD5A1, SRD5A2

Products for genes affiliated with Gynecomastia

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Sources for Gynecomastia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet