MCID: GYN001
MIFTS: 46

Gynecomastia malady

Endocrine diseases, Reproductive diseases categories

Summaries for Gynecomastia

About this section
Sources:
66Wikipedia, 34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
Wikipedia:66 Gynecomastia /??a?n?k??m more...

MalaCards: Gynecomastia, also known as gynaecomastia, is related to leydig cell tumor and pseudohermaphroditism. An important gene associated with Gynecomastia is HSD17B3 (hydroxysteroid (17-beta) dehydrogenase 3), and among its related pathways are Androgen Signaling and Steroid hormone biosynthesis. The drugs tamoxifen and tamoxifen citrate and the compounds Androst-5-ene-3b,17b-diol and vorozole have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and skin.

Aliases & Classifications for Gynecomastia

About this section
Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH, 41NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Endocrine diseases, Reproductive diseases


Aliases & Descriptions:

gynecomastia 9 11 46 63
gynaecomastia 9


External Ids:

Disease Ontology9 DOID:12698
MeSH36 D006177
NCIt41 C3073

Related Diseases for Gynecomastia

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Gynecomastia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 171)
idRelated DiseaseScoreTop Affiliating Genes
1leydig cell tumor30.6INHA, CYP19A1
2pseudohermaphroditism30.5CYP19A1, HSD17B3, SRY
3peutz-jeghers syndrome30.5CYP19A1, INHA
4breast cancer30.4APOD, SHBG, CYP19A1
5hypogonadism30.4CYP19A1, SHBG
6prostate cancer30.4CYP19A1, INHA, SHBG, HSD17B3, APOD, SRY
7sertoli cell tumor30.3INHA, CYP19A1
8hypospadias30.1HSD17B3, SRY
9partial androgen insensitivity syndrome30.1CYP19A1, SHBG
10testicular cancer30.0SHBG, INHA
11androgen insensitivity syndrome30.0SHBG, HSD17B3, SRY
12cryptorchidism30.0SRY, SHBG, CYP19A1
13short stature30.0SRY, SHBG, CYP19A1
14congenital adrenal hyperplasia30.0SRY, CYP19A1
15hermaphroditism29.9SRY
16precocious puberty29.8SHBG, CYP19A1
17adrenal adenoma29.8INHA, CYP19A1
18breast cyst29.8APOD, CYP19A1
19klinefelter's syndrome29.8CYP19A1, INHA, SHBG
20osteoporosis29.8SHBG, CYP19A1
21prostatitis10.5
22ductal carcinoma in situ10.3
23obesity10.2
24arthritis10.2
25rheumatoid arthritis10.2
26aromatase excess syndrome10.2
27male breast cancer10.2
28hepatocellular carcinoma10.2
29leukemia10.2
3017-beta hydroxysteroid dehydrogenase 3 deficiency10.2
31hypoactive sexual desire disorder10.1SHBG
32neurofibromatosis10.1
33kennedy's disease10.1
34infant gynecomastia10.1
35hyperprolactinemia10.1
36adenoma10.1
37myeloid leukemia10.1
38mental retardation gynecomastia obesity x-linked10.1
39ovarian disease10.1CYP19A1
40dysgerminoma10.0INHA, SRY
41amenorrhea10.0SHBG, SRY
42turner syndrome10.0SRY, SHBG
43premature ovarian failure10.0INHA, SHBG
44hypogonadism, hypergonadotropic10.0CYP19A1, SHBG
45complete androgen insensitivity syndrome10.0CYP19A1, SHBG
46androgenic alopecia10.0SHBG, CYP19A1
47endometrial stromal sarcoma10.0CYP19A1, INHA
48anovulation10.0CYP19A1, SHBG
49aorta atresia10.0CYP19A1, INHA
50abrikosov's tumor10.0CYP19A1, INHA

Graphical network of the top 20 diseases related to Gynecomastia:



Diseases related to gynecomastia

Symptoms for Gynecomastia

About this section

Drugs & Therapeutics for Gynecomastia

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Gynecomastia

Drug clinical trials:

Search ClinicalTrials for Gynecomastia

Search NIH Clinical Center for Gynecomastia

Search CenterWatch for Gynecomastia

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Gynecomastia

About this section

Anatomical Context for Gynecomastia

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Gynecomastia:

34
Breast, Prostate, Skin, Lung, Testis, Myeloid, Spinal cord, Liver, Heart, Thyroid, Pituitary

Animal Models for Gynecomastia or affiliated genes

About this section

Publications for Gynecomastia

About this section
Sources:
53PubMed
See all sources

Articles related to Gynecomastia:

(show top 50)    (show all 522)
idTitleAuthorsYear
1
Commentary on "gynecomastia: etiologies, clinical presentations, diagnosis, and management". (24389787)
2014
2
An Aroma of Complexity: How the Unique Genetics of Aromatase (CYP19A1) Explain Diverse Phenotypes From Hens and Hyenas to Human Gynecomastia, and Testicular and Other Tumors. (24311795)
2013
3
Prepubertal gynecomastia in two monozygotic twins with Peutz-Jeghers syndrome: clinical and surgical management. (23968963)
2013
4
18F-FDG PET/CT in detection of gynecomastia in patients with hepatocellular carcinoma. (23809917)
2013
5
A randomized trial comparing tamoxifen therapy vs. tamoxifen prophylaxis in bicalutamide-induced gynecomastia. (22502790)
2012
6
SRY-positive 46, XY male with vanishing testis syndrome, feminization and gynecomastia. (23441485)
2012
7
Euprolactinemic gynecomastia and galactorrhea with risperidone-fluvoxamine combination. (22506441)
2011
8
Unilateral gynecomastia in a young adult. (21673478)
2011
9
Gynecomastia - a difficult diagnostic problem. (21528484)
2011
10
Fibromatosis of the male breast with concurrent florid-type gynecomastia: Report of a case and review of literature. (21511401)
2011
11
Prepubertal gynecomastia in two monozygotic twins with Peutz-Jeghers syndrome: two years' treatment with anastrozole and genetic study. (21335955)
2011
12
Treatment of adolescent gynecomastia. (20223338)
2010
13
High grade gynecomastia: surgical correction and potential impact on erectile function. (20233285)
2010
14
Gynecomastia, obesity and underdeveloped testis and penis: suspected hypophysitis successfully cured with low dose of cyclosporine A. (19951616)
2009
15
It is reasonable to do endocrine investigation in gynecomastia. (18216522)
2008
16
Leydig cell hyperplasia revealed by gynecomastia. (18660859)
2008
17
Phenotype of patients with gynecomastia]. (18465688)
2008
18
Testicular interstitial cell tumor and gynecomastia in a rabbit. (17606513)
2007
19
Childhood gynecomastia: a clinical analysis of 240 cases. (17937844)
2007
20
Clonidine-induced gynecomastia and hyperprolactinemia in a 6-year-old child. (16401171)
2005
21
Gynecomastia and mucosal lentigines in an 8-year-old boy. (16198789)
2005
22
Sertoli cell tumor causing prepubertal gynecomastia in a boy with peutz-jeghers syndrome: the outcome of 1-year treatment with the aromatase inhibitor testolactone. (15947469)
2005
23
Possible involvement of aromatase overexpression induced by cyclo-oxygenase-2 in the pathogenesis of idiopathic gynecomastia. (16392624)
2005
24
A case-control study of gynecomastia in HIV-1-infected patients receiving HAART. (14959701)
2004
25
Sonography of pediatric male breast masses: gynecomastia and beyond. (15378216)
2004
26
Psychosocial adjustment of two boys with gynecomastia. (15151602)
2004
27
Gynecomastia following chemotherapy for testicular cancer. (12660472)
2003
28
Expression of BRCA1 and BRCA2 in male breast cancers and gynecomastias. (12680164)
2003
29
Gynecomastia in male HIV patients MRI and US findings. (12213363)
2002
30
Gynecomastia: complications of the subcutaneous mastectomy. (11842972)
2002
31
Occult Leydig cell tumor in a patient with gynecomastia. (11497478)
2001
32
Isolated relapse of acute lymphoblastic leukemia in the breast masquerading as gynecomastia. (10896624)
2000
33
Treatment of adolescent gynecomastia using a bipedicle technique. (9523606)
1998
34
Gynecomastia following spinal cord disorder. (9161376)
1997
35
Evaluation and treatment of gynecomastia. (9105209)
1997
36
Gynecomastia with metoclopramide use in pediatric patients. (9077721)
1997
37
Report of an XX male with hypospadias and pubertal gynecomastia, SRY gene negative in blood leukocytes but SRY gene positive in testicular cells. (9030973)
1997
38
Prepubertal gynecomastia during growth hormone therapy. (7699552)
1995
39
Case report: finasteride-induced gynecomastia in a 62-year-old man. (7539584)
1995
40
Correction of gynecomastia with an inframammary incision and subsequent scar. (7480316)
1995
41
Nipple placement in simple mastectomy with free nipple grafting for severe gynecomastia. (7972427)
1994
42
Medications that cause gynecomastia. (8248425)
1993
43
Metastatic hepatocellular carcinoma of the breast, simulating gynecomastia: diagnosis by fine-needle aspiration biopsy. (1334827)
1992
44
Infantile gynecomastia with bloody nipple discharge. (1552426)
1992
45
Mineralocorticoids in the mechanism of gynecomastia in adrenal hyperplasia caused by 11 beta-hydroxylase deficiency. (1993958)
1991
46
Re: Liposuction of giant lipoma and the treatment of gynecomastia without sharp excision. (2029145)
1991
47
Hormonal studies and physical maturation in adolescent gynecomastia. (2137877)
1990
48
The occurrence of gynecomastia upon withdrawal of clomiphene citrate treatment for idiopathic oligospermia. (6773824)
1980
49
Leydig-cell tumor of the testis with gynecomastia and elevated estrogen levels. (868795)
1977
50
Mediastinal seminoma. Associated with exophthalmos and gynecomastia. (4819703)
1974

Variations for Gynecomastia

About this section

Expression for genes affiliated with Gynecomastia

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Gynecomastia

Search GEO for disease gene expression data for Gynecomastia.

Pathways for genes affiliated with Gynecomastia

About this section
Sources:
51PathCards, 54QIAGEN, 31KEGG, 39NCBI BioSystems Database, 56Reactome, 61Thomson Reuters
See all sources

Pathways related to Gynecomastia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5SRY, SHBG
2
Show member pathways
Glucocorticoid andamp; Mineralcorticoid Metabolism39
9.4HSD17B3, CYP19A1
3
Show member pathways
9.4HSD17B3, CYP19A1
4
Show member pathways
Estrogen biosynthesis61
Androstenedione and testosterone biosynthesis and metabolism p.161
9.4HSD17B3, CYP19A1
5
Show member pathways
estradiol biosynthesis II39
androgen biosynthesis39
estradiol biosynthesis I39
progesterone biosynthesis39
9.4HSD17B3, CYP19A1
69.3CYP19A1, INHA

Compounds for genes affiliated with Gynecomastia

About this section
Sources:
25HMDB, 46Novoseek, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 52PharmGKB
See all sources

Compounds related to Gynecomastia according to GeneCards/GeneDecks:

(show top 50)    (show all 57)
idCompoundScoreTop Affiliating Genes
1Androst-5-ene-3b,17b-diol259.9HSD17B3, CYP19A1
2vorozole469.8SHBG, CYP19A1
3formestane469.8CYP19A1, SHBG
4ment469.8CYP19A1, SHBG
5atrazine469.8SHBG, CYP19A1
6androstenediol469.7SHBG, CYP19A1
7carbimazole46 1210.7SHBG, CYP19A1
8nandrolone46 2510.7SHBG, CYP19A1
9goserelin46 30 1211.7SHBG, CYP19A1
10megestrol acetate469.7CYP19A1, SHBG
115alpha-androstane-3alpha,17beta-diol469.7CYP19A1, SHBG
12leuprolide acetate469.7SHBG, CYP19A1
13finasteride46 62 25 1212.7CYP19A1, SHBG
14exemestane46 52 62 1212.7SHBG, CYP19A1
15anastrozole46 52 1211.7SHBG, CYP19A1
16toremifene46 1210.7CYP19A1, SHBG
17naringenin46 1210.7CYP19A1, SHBG
18Testosterone sulfate259.7CYP19A1, HSD17B3
19clomiphene citrate469.7CYP19A1, SHBG
20tibolone469.7SHBG, CYP19A1
21danazol46 25 1211.7SHBG, CYP19A1
22cyproteroneacetate469.7SHBG, CYP19A1
23letrozole46 52 62 1212.6SHBG, CYP19A1
24levonorgestrel46 62 30 1212.6CYP19A1, SHBG
2517-hydroxyprogesterone46 2510.6SHBG, CYP19A1
26flutamide46 62 1211.6SHBG, CYP19A1
27estrone sulfate46 2510.6CYP19A1, SHBG
2825-hydroxyvitamin d469.6SHBG, CYP19A1
2917beta-hydroxysteroid469.6CYP19A1, HSD17B3
30diethylstilbestrol46 30 1211.6SHBG, CYP19A1
313beta-hydroxysteroid469.5INHA, CYP19A1
32ketoconazole46 30 25 1212.5CYP19A1, SHBG
33dehydroepiandrosterone sulfate469.5CYP19A1, SHBG
34biotin46 25 1211.4INHA, SHBG, SRY
35progestins469.4SHBG, CYP19A1
36estrone46 30 25 1212.3HSD17B3, SHBG, CYP19A1
37raloxifene46 52 30 1212.3CYP19A1, SHBG
38progestin469.3SHBG, CYP19A1
39metformin46 52 1211.2SHBG, CYP19A1
40gnrh469.2SHBG, INHA, CYP19A1
41agarose469.1INHA, APOD, SRY
42dhea469.0SHBG, CYP19A1
43androstenedione46 259.9CYP19A1, INHA, SHBG, HSD17B3
44tamoxifen46 52 30 1211.8CYP19A1, SHBG, APOD
45dihydrotestosterone46 30 25 1211.5CYP19A1, SHBG, APOD, SRY
46progesterone46 30 62 25 1212.4CYP19A1, INHA, SHBG, APOD
47estradiol46 25 1210.4SRY, HSD17B3, SHBG, INHA, CYP19A1
48estrogen468.0CYP19A1, INHA, SHBG, HSD17B3, APOD
49steroid468.0SRY, APOD, SHBG, INHA, CYP19A1
50testosterone46 62 25 1210.6SRY, APOD, HSD17B3, SHBG, INHA, CYP19A1

GO Terms for genes affiliated with Gynecomastia

About this section
Sources:
17Gene Ontology
See all sources

Biological processes related to Gynecomastia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1steroid metabolic processGO:0082029.4HSD17B3, CYP19A1

Products for genes affiliated with Gynecomastia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Gynecomastia

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet