MCID: HPY002
MIFTS: 44

H. Pylori Infection malady

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Summaries for H. Pylori Infection

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47OMIM, 33MalaCards
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MalaCards: H. Pylori Infection, also known as helicobacter pylori infection, is related to gastritis and duodenal ulcer. An important gene associated with H. Pylori Infection is IFNGR1 (interferon gamma receptor 1), and among its related pathways are Type II interferon signaling (IFNG) and Immune response IFN gamma signaling pathway. The compounds anakinra and toxin-1 have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and heart, and related mouse phenotypes are tumorigenesis and immune system.

Description from OMIM:47 600263

Aliases & Classifications for H. Pylori Infection

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47OMIM, 62UMLS
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Aliases & Descriptions:

h. pylori infection 47
helicobacter pylori infection 62


Related Diseases for H. Pylori Infection

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17GeneCards, 18GeneDecks
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Diseases related to H. Pylori Infection via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 83)
idRelated DiseaseScoreTop Affiliating Genes
1gastritis31.1CDX2, IL1RN
2duodenal ulcer31.1CYP2C19, MUC6, IL1RN
3atrophic gastritis30.7IL1RN, CDX2
4gastric adenocarcinoma30.7IL1RN, CDX2, CDH1
5gastric cancer risk after h. pylori infection30.7IL1RN
6adenocarcinoma30.6CDH1, CDX2, CXCR1, MUC6
7colorectal cancer30.4CYP2C19, MUC6, CDX2, CDH1
8esophagitis30.3CYP2C19, CDX2
9barrett's esophagus30.3MUC6, CDX2
10duodenitis10.7
11gastric ulcer10.6
12dyspepsia10.6
13gastroduodenitis10.6
14purpura10.5
15pancreatitis10.4
16insulin resistance10.4
17goiter10.3
18peptic ulcer disease10.3
19blindness10.3
20malt lymphoma10.3
21coronary artery disease10.2
22cystic fibrosis10.2
23cholera10.2
24follicular lymphoma10.2
25gastroparesis10.2
26irritable bowel syndrome10.2
27sjogren's syndrome10.2
28arteriovenous malformation10.2
29primary hyperparathyroidism10.2
30behcet's disease10.2
31artery disease10.2
32hepatic encephalopathy10.2
33hepatitis10.2
34hyperparathyroidism10.2
35hypertension10.2
36liver disease10.2
37gastric outlet obstruction10.2
38epstein-barr virus-associated gastric carcinoma10.2
39degenerative disc disease10.1IL1B
40hereditary diffuse gastric cancer10.1CDH1
41dengue shock syndrome10.1IL1RN
42chronic infantile neurological cutaneous articular syndrome10.1IL1B, IL1RN
43chorioamnionitis10.1IL1B, IL1RN
44cerebral malaria10.1IL1B, IL1RN
45toxic shock syndrome10.1IL1RN, IL1B
46adult respiratory distress syndrome10.1IL1RN, IL1B
47microinvasive gastric cancer10.1CDH1, CDX2
48newborn respiratory distress syndrome10.1IL1B, IL1RN
49stomach cancer10.1CDH1, CDX2
50tubular adenocarcinoma10.1CDX2, CDH1

Graphical network of the top 20 diseases related to H. Pylori Infection:



Diseases related to h. pylori infection

Symptoms for H. Pylori Infection

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47OMIM
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Symptoms by clinical synopsis from OMIM:

600263

Clinical features from OMIM:

600263

Drugs & Therapeutics for H. Pylori Infection

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for H. Pylori Infection

Search NIH Clinical Center for H. Pylori Infection

Genetic Tests for H. Pylori Infection

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Anatomical Context for H. Pylori Infection

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33MalaCards
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MalaCards organs/tissues related to H. Pylori Infection:

33
Colon, Testes, Heart, Liver, T cells, Monocytes, B cells

Animal Models for H. Pylori Infection or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to H. Pylori Infection:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7CDH1, CDX2, IL1B, IFNGR1
2MP:00053878.6CDH1, IL1B, IL1RN, IFNGR1, PTPRZ1
3MP:00053858.1IFNGR1, IL1RN, IL1B, CDX2, CDH1

Publications for H. Pylori Infection

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52PubMed
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Articles related to H. Pylori Infection:

(show top 50)    (show all 286)
idTitleAuthorsYear
1
Prevalence of H. pylori infection and atrophic gastritis among symptomatic and dyspeptic adults in Kazakhstan. A hospital-based screening study using a panel of serum biomarkers. (24123036)
2013
2
H. pylori infection and gastric cancer: state of the art (review). (23165522)
2013
3
Leptin, CD4(+) T(reg) and the prospects for vaccination against H. pylori infection. (23087691)
2012
4
Triple therapy with ecabet sodium, amoxicillin and lansoprazole for 2 weeks as the rescue regimen for H. pylori infection. (21372444)
2011
5
Low prevalence of H. pylori infection in HIV-positive patients in the northeast of Brazil. (21333017)
2011
6
Correlates shift work with increased risk of gastrointestinal complaints or frequency of gastritis or peptic ulcer in H. pylori-infected shift workers? (20012444)
2010
7
Characteristics and interactions of Helicobacter pylori and H. pylori-infected human gastroduodenal epithelium in peptic ulcer: a transmission electron microscopy study. (19160047)
2010
8
The reliability of ELISA in predicting H. pylori infection in dyspeptic populations under age 45. (20037501)
2010
9
The BB genotype of heat-shock protein (HSP) 70-2 gene is associated with gastric pre-malignant condition in H. pylori-infected older patients. (19661373)
2009
10
Endoscopic and histopathologic findings associated with H. pylori infection in very young children. (18594977)
2009
11
Retractions. Re: "Ethics of administering gatifloxacin for H. pylori infection in asymptomatic veterans" by D. Vaira, A. Zullo, V. de Francesco, G. Scaccianoce and "Ethical issues regarding recent anti-H. pylori clinical studies" by D. Y. Graham . (18194502)
2008
12
CpG island hypermethylation of tumor-suppressor genes in H. pylori-infected non-neoplastic gastric mucosa is linked with gastric cancer risk. (18205664)
2008
13
E-cadherin promoter hypermethylation induced by interleukin-1beta treatment or H. pylori infection in human gastric cancer cell lines. (18249489)
2008
14
Aberrant DNA methylation in non-neoplastic gastric mucosa of H. Pylori infected patients and effect of eradication. (17509026)
2007
15
Review: eradication therapy supplemented by probiotics increased eradication rates and reduced side effects in H. pylori infection. (17474672)
2007
16
Clinical role and importance of fluorescence in situ hybridization method in diagnosis of H pylori infection and determination of clarithromycin resistance in H pylori eradication therapy. (17278188)
2007
17
Improvement in symptoms after H2-receptor antagonist-based therapy for eradication of H pylori infection. (17657838)
2007
18
Genetic variants in matrix metalloproteinase genes are associated with development of gastric ulcer in H. Pylori infection. (16405530)
2006
19
Short mucin 6 alleles are associated with H pylori infection. (17009402)
2006
20
What is the most sensitive non-invasive test for initial diagnosis of H. pylori infection in adults? (16821494)
2006
21
Comparison of invasive methods and two different stool antigen tests for diagnosis of H pylori infection in patients with gastric bleeding. (16830376)
2006
22
Insulin resistance in H pylori infection and its association with oxidative stress. (17106938)
2006
23
First-line eradication of H pylori infection in Europe: a meta-analysis based on congress abstracts, 1997-2004. (16981260)
2006
24
Efficacy of sonicated and acid-extractable antigens in the serodiagnosis of H. pylori infection in peptic ulcer patients. (15928442)
2005
25
Poliovirus replicons encoding the B subunit of Helicobacter pylori urease protect mice against H. pylori infection. (15603891)
2005
26
Does H. Pylori infection play a role in idiopathic thrombocytopenic purpura and in other autoimmune diseases? (15929756)
2005
27
Levofloxacin- versus metronidazole-based rescue therapy for H. pylori infection in Japan. (16040284)
2005
28
Review article: should NSAID/low-dose aspirin takers be tested routinely for H. pylori infection and treated if positive? Implications for primary risk of ulcer and ulcer relapse after initial healing. (14725573)
2004
29
Genetic differences in interleukin-1 betapolymorphisms among four Asian populations: an analysis of the Asian paradox between H. pylori infection and gastric cancer incidence. (12725322)
2003
30
Distribution of Helicobacter pylori organisms in the stomachs of children with H. pylori infection. (12454819)
2002
31
Seroprevalence of H. pylori infection and symptoms of upper gastrointestinal tract disease in two groups of health-care workers. (11855543)
2002
32
Helicobacter pylori (H pylori) infection in Greece: the changing prevalence during a ten-year period and its antigenic profile. (12014991)
2002
33
Prevalence of H. pylori-infection in family members of H. pylori positive and its influence on the reinfection rate after successful eradication therapy: a two-year follow-up. (12055660)
2002
34
Evaluation of therapeutic efficacy of adjuvant Helicobacter pylori whole cell sonicate in mice with chronic H. pylori infection. (12437028)
2002
35
Gastric epithelial proliferation and p53 and p21 expression in a general population sample: relations to age, sex, and mucosal changes associated with H. pylori infection. (12141817)
2002
36
Clarithromycin resistance, but not CYP2C-19 polymorphism, has a major impact on treatment success in 7-day treatment regimen for cure of H. pylori infection: a multiple logistic regression analysis. (11713950)
2001
37
Gastroenterologists do have a higher risk of acquiring H pylori infection (10894715)
2000
38
Guideline on diagnosis and treatment of H. pylori infection: report from the 6th Annual Meeting of the Japanese Society for Helicobacter Research. (11095142)
2000
39
H pylori infection. Review of the guideline for diagnosis and treatment. (10872345)
2000
40
Reply: An age- and gender-specific analysis of H. pylori infection. (17337993)
1999
41
PPI-based triple therapy in the eradication of H. pylori infection. (10490365)
1999
42
Serology and urea breath test in the diagnosis of H. pylori infection. (10367284)
1999
43
Influence of H. pylori infection on meal-stimulated gastric acid secretion and gastroesophageal acid reflux. (10600812)
1999
44
New stool immunoassay offers routine diagnostic tool for H pylori infection. (10574899)
1999
45
An increased number of follicles containing activated CD69+ helper T cells and proliferating CD71+ B cells are found in H. pylori-infected gastric mucosa. (9576451)
1998
46
Cost-effectiveness of noninvasive testing and treatment strategies for H. pylori infection in children with dyspepsia. (9576448)
1998
47
37 kBq 14C-urea breath test and gastric biopsy analyses of H. pylori infection. (9033373)
1997
48
Pantoprazole versus omeprazole in one-week low-dose triple therapy for curve of H. pylori infection. (9382084)
1997
49
pH and cure of H. pylori infection: it is difficult to have insights when one is in the dark. (7717344)
1995
50
Effect of IL-4 on peripheral blood lymphocyte proliferation: implication in immunopathogenesis of H. pylori infection. (8847090)
1995

Variations for H. Pylori Infection

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Expression for genes affiliated with H. Pylori Infection

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with H. Pylori Infection

Search GEO for disease gene expression data for H. Pylori Infection.

Pathways for genes affiliated with H. Pylori Infection

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50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 54R&D Systems, 55Reactome, 12EMD Millipore
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Pathways related to H. Pylori Infection according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IFNGR1, IL1B
2
Show member pathways
IFN-gamma pathway38
9.8IFNGR1, IL1B
3
Show member pathways
IL27-mediated signaling events38
9.8IL1B, IFNGR1
4
Show member pathways
IL-1 Signaling Pathway38
IL1-mediated signaling events38
9.7IL1B, IL1RN
59.6IL1B, CDX2
69.6IL1B, CYP2C19
79.5CDX2, CDH1
8
Show member pathways
9.4IFNGR1, IL1RN, IL1B

Compounds for genes affiliated with H. Pylori Infection

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45Novoseek, 11DrugBank, 51PharmGKB, 24HMDB, 29IUPHAR, 61Tocris Bioscience, 3BitterDB
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Compounds related to H. Pylori Infection according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1anakinra45 1111.1IL1RN, IL1B
2toxin-14510.1IL1RN, IL1B
3gold sodium thiomalate4510.1IL1RN, IL1B
4cuprophan4510.0IL1RN, IL1B
5polysulfone4510.0IL1B, IL1RN
6polymyxin b4510.0IL1B, IL1RN
7leflunomide45 51 1112.0IL1B, IL1RN
8rabeprazole45 51 24 1113.0CYP2C19, IL1B
9chi 24510.0CDH1, IL1RN
10lipoteichoic acid4510.0IL1B, IL1RN
11sulfasalazine29 45 51 1112.9IL1B, IL1RN
12amoxicillin45 51 1111.9CYP2C19, IL1RN
13p00001459.9IL1RN, CDH1
14clarithromycin45 1110.9IL1RN, CYP2C19
15ns 39845 6110.9IL1RN, IL1B
16alginate459.8IL1RN, IL1B
17omeprazole45 51 29 24 1113.8IL1B, CYP2C19
18groalpha459.8IL1B, CXCR1
19etanercept45 51 1111.8IL1B, IL1RN
20propofol45 51 1111.7IL1RN, CYP2C19
21tgf beta1459.7CDH1, IL1B, IL1RN
22hyaluronic acid45 2410.6CDH1, IL1B, IL1RN
23lansoprazole45 51 24 1112.6CYP2C19, IL1RN, IL1B
24aspirin45 51 29 2412.6IL1RN, IL1B, CDH1
25ibuprofen45 29 51 24 1113.6IL1B, IL1RN, CYP2C19
26methotrexate51 45 1111.6CDH1, IL1B, IL1RN
27sb 20358045 6110.6CDH1, IL1B, IL1RN
28troglitazone45 29 61 1112.6CYP2C19, IL1B, CDH1
29leukotriene b445 61 2411.5IL1B, IL1RN, CXCR1
30formaldehyde45 2410.5CDH1, IL1RN, CYP2C19
31histamine45 29 2411.5IL1RN, IL1B, CDH1
32endotoxin459.5IL1B, IL1RN, CXCR1
33fmlp459.5IL1B, IL1RN, CXCR1
34herbimycin a45 6110.4CXCR1, IL1B, CDH1
35rantes459.4IL1B, IL1RN, CXCR1
36il 10459.4IL1RN, IL1B
37vitamin d459.4IL1RN, CDX2, CDH1
38indomethacin45 29 61 1112.2CYP2C19, IL1RN, IL1B, CDH1
39genistein45 29 61 3 24 1114.0CDH1, IL1B, CXCR1
40vegf459.0CXCR1, IL1RN, IL1B, CDH1
41arachidonic acid45 29 24 1111.9CYP2C19, CXCR1, IL1B, CDH1
42oxygen45 249.9CYP2C19, CXCR1, IFNGR1, IL1RN
43cysteine458.7CDH1, CDX2, IL1RN, CXCR1
44paraffin458.6CDH1, CDX2, MUC6
45dexamethasone45 51 29 1111.5CYP2C19, CXCR1, IL1RN, IL1B, CDH1
46retinoic acid45 249.5CDH1, IL1B, IL1RN, CXCR1, CYP2C19
47progesterone45 29 61 24 1112.2CDH1, CDX2, IL1RN, MUC6, CYP2C19
48estrogen458.2CYP2C19, MUC6, IL1RN, CDX2, CDH1
49tyrosine457.7CDH1, CDX2, IL1RN, IFNGR1, CXCR1, PTPRZ1
50calcium45 51 24 1110.6MUC6, CXCR1, IL1RN, CDX2, CDH1

GO Terms for genes affiliated with H. Pylori Infection

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16Gene Ontology
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Biological processes related to H. Pylori Infection according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fever generationGO:0016609.6IL1B, IL1RN
2trophectodermal cell differentiationGO:0018299.2CDH1, CDX2
3positive regulation of transcription, DNA-templatedGO:0458939.1CDH1, CDX2, IL1B

Molecular functions related to H. Pylori Infection according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:0051499.7IL1B, IL1RN

Products for genes affiliated with H. Pylori Infection

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Sources for H. Pylori Infection

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet