MCID: HPY002
MIFTS: 46

H. Pylori Infection malady

Genetic diseases (common) category

Aliases & Classifications for H. Pylori Infection

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H. Pylori Infection, Aliases & Descriptions:

Name: H. Pylori Infection 45
Helicobacter Pylori Infection 45 22 60
 
H. Pylori Infection, Susceptibility to 10
Helicobacter Pylori Infections 32


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


External Ids:

OMIM45 600263

Summaries for H. Pylori Infection

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MedlinePlus:32 Helicobacter pylori (h. pylori) is a type of bacteria that causes infection in the stomach. it is found in about two-thirds of the world's population. it may be spread by unclean food and water, but researchers aren't sure. it causes peptic ulcers and can also cause stomach cancer. if you have symptoms of a peptic ulcer, your doctor will test your blood, breath or stool to see if it contains h. pylori. the best treatment is a combination of antibiotics and acid-reducing medicines. you will need to be tested after treatment to make sure the infection is gone. to help prevent an h. pylori infection, you should wash your hands after using the bathroom and before eating eat properly prepared food drink water from a clean, safe source nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary: H. Pylori Infection, also known as helicobacter pylori infection, is related to gastritis and gastric cancer risk after h. pylori infection, and has symptoms including helicobacter pylori infection An important gene associated with H. Pylori Infection is IFNGR1 (interferon gamma receptor 1), and among its related pathways are Th1 Differentiation and Type II interferon signaling (IFNG). The compounds anakinra and toxin-1 have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and kidney, and related mouse phenotypes are tumorigenesis and immune system.

OMIM:45 Helicobacter pylori is a microaerophilic, gram-negative bacterium that colonizes the gastric mucosa of approximately... (600263) more...

Related Diseases for H. Pylori Infection

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Diseases related to H. Pylori Infection via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 195)
idRelated DiseaseScoreTop Affiliating Genes
1gastritis31.6CDX2, IL1RN
2gastric cancer risk after h. pylori infection31.4CDH1
3atrophic gastritis31.1IL1RN, CDX2
4duodenal ulcer31.1CYP2C19, MUC6, IL1RN
5gastric adenocarcinoma30.9IL1RN, CDX2, CDH1
6esophagitis30.8CYP2C19, CDX2
7ulcerative colitis30.8IL1B, IL1RN, CXCR1
8gallbladder cancer30.7CDX2, CDH1
9stomach cancer30.7CDH1, CDX2
10neuroendocrine tumor30.7CDX2, CDH1
11adenocarcinoma30.6CDH1, CDX2, CXCR1, MUC6
12colorectal cancer30.5CDH1, CDX2, CXCR1
13pancreatic cancer30.5CXCR1, IL1RN, CDX2, CDH1
14arthritis30.5IL1B, IL1RN, CXCR1
15tuberculosis30.2CXCR1, IFNGR1, IL1B
16adenoma30.2CDH1, CDX2, MUC6
17gastric lymphoma10.8
18deficiency anemia10.8
19iron deficiency anemia10.8
20duodenitis10.7
21laryngitis10.7
22duodenogastric reflux10.6
23lymphocytic gastritis10.6
24pernicious anemia10.6
25open-angle glaucoma10.6
26gastric ulcer10.6
27dyspepsia10.6
28gastroduodenitis10.6
29asthma10.6
30bile reflux10.6
31neuropathy10.6
32thyroiditis10.6
33autoimmune thyroiditis10.5
34allergic asthma10.5
35giardiasis10.5
36laryngeal squamous cell carcinoma10.5
37endotheliitis10.5
38intervertebral disc disease10.5IL1B
39purpura10.5
40dengue shock syndrome10.5IL1RN
41atherosclerosis10.5
42primary biliary cirrhosis10.5
43cardia cancer10.5
44graves' disease10.5
45zollinger-ellison syndrome10.5
46angioedema10.5
47colitis10.5
48food allergy10.5
49urticaria10.5
50gastroesophageal reflux10.4

Graphical network of the top 20 diseases related to H. Pylori Infection:



Diseases related to h. pylori infection

Symptoms for H. Pylori Infection

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Symptoms by clinical synopsis from OMIM:

600263

Clinical features from OMIM:

600263

HPO human phenotypes related to H. Pylori Infection:

id Description Frequency HPO Source Accession
1 helicobacter pylori infection HP:0005202

Drugs & Therapeutics for H. Pylori Infection

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Drug clinical trials:

Search ClinicalTrials for H. Pylori Infection

Search NIH Clinical Center for H. Pylori Infection

Genetic Tests for H. Pylori Infection

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Genetic tests related to H. Pylori Infection:

id Genetic test Affiliating Genes
1 Helicobacter Pylori Infection, Susceptibility to22

Anatomical Context for H. Pylori Infection

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MalaCards organs/tissues related to H. Pylori Infection:

31
Testes, Colon, Kidney, Liver, Heart, T cells, Monocytes, B cells, Neutrophil

Animal Models for H. Pylori Infection or affiliated genes

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MGI Mouse Phenotypes related to H. Pylori Infection:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7CDH1, CDX2, IL1B, IFNGR1
2MP:00053878.6CDH1, IL1B, IL1RN, IFNGR1, PTPRZ1
3MP:00053858.1IFNGR1, IL1RN, IL1B, CDX2, CDH1

Publications for H. Pylori Infection

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Articles related to H. Pylori Infection:

(show top 50)    (show all 305)
idTitleAuthorsYear
1
The role of H. pylori infection in gall bladder cancer: clinicopathological study. (25877756)
2015
2
Coenzyme q10 in combination with triple therapy regimens ameliorates oxidative stress and lipid peroxdiation in chronic gastritis associated with H. pylori infection. (25854786)
2015
3
Letter: Bismuth quadruple therapy with Pylera for H. pylori infection. (25123391)
2014
4
CYP2E1 Genetic Polymorphism with Dietary, Tobacco, Alcohol Habits, H. pylori Infection Status and Susceptibility to Stomach Cancer in Mizoram, India. (25374213)
2014
5
Antibiotics resistance of Helicobacter pylori and treatment modalities in children with H. pylori infection. (24678329)
2014
6
Whole-miRNome profiling identifies prognostic serum miRNAs in esophageal adenocarcinoma: the influence of H. pylori infection status. (25381453)
2014
7
Prevalence of H. pylori infection and atrophic gastritis among symptomatic and dyspeptic adults in Kazakhstan. A hospital-based screening study using a panel of serum biomarkers. (24123036)
2013
8
H. pylori infection and gastric cancer: state of the art (review). (23165522)
2013
9
Correlates shift work with increased risk of gastrointestinal complaints or frequency of gastritis or peptic ulcer in H. pylori-infected shift workers? (20012444)
2010
10
Characteristics and interactions of Helicobacter pylori and H. pylori-infected human gastroduodenal epithelium in peptic ulcer: a transmission electron microscopy study. (19160047)
2010
11
The BB genotype of heat-shock protein (HSP) 70-2 gene is associated with gastric pre-malignant condition in H. pylori-infected older patients. (19661373)
2009
12
Endoscopic and histopathologic findings associated with H. pylori infection in very young children. (18594977)
2009
13
Retractions. Re: "Ethics of administering gatifloxacin for H. pylori infection in asymptomatic veterans" by D. Vaira, A. Zullo, V. de Francesco, G. Scaccianoce and "Ethical issues regarding recent anti-H. pylori clinical studies" by D. Y. Graham . (18194502)
2008
14
CpG island hypermethylation of tumor-suppressor genes in H. pylori-infected non-neoplastic gastric mucosa is linked with gastric cancer risk. (18205664)
2008
15
E-cadherin promoter hypermethylation induced by interleukin-1beta treatment or H. pylori infection in human gastric cancer cell lines. (18249489)
2008
16
Aberrant DNA methylation in non-neoplastic gastric mucosa of H. Pylori infected patients and effect of eradication. (17509026)
2007
17
Review: eradication therapy supplemented by probiotics increased eradication rates and reduced side effects in H. pylori infection. (17474672)
2007
18
Clinical role and importance of fluorescence in situ hybridization method in diagnosis of H pylori infection and determination of clarithromycin resistance in H pylori eradication therapy. (17278188)
2007
19
Genetic variants in matrix metalloproteinase genes are associated with development of gastric ulcer in H. Pylori infection. (16405530)
2006
20
Short mucin 6 alleles are associated with H pylori infection. (17009402)
2006
21
What is the most sensitive non-invasive test for initial diagnosis of H. pylori infection in adults? (16821494)
2006
22
Comparison of invasive methods and two different stool antigen tests for diagnosis of H pylori infection in patients with gastric bleeding. (16830376)
2006
23
Insulin resistance in H pylori infection and its association with oxidative stress. (17106938)
2006
24
Efficacy of sonicated and acid-extractable antigens in the serodiagnosis of H. pylori infection in peptic ulcer patients. (15928442)
2005
25
Poliovirus replicons encoding the B subunit of Helicobacter pylori urease protect mice against H. pylori infection. (15603891)
2005
26
Does H. Pylori infection play a role in idiopathic thrombocytopenic purpura and in other autoimmune diseases? (15929756)
2005
27
Levofloxacin- versus metronidazole-based rescue therapy for H. pylori infection in Japan. (16040284)
2005
28
Review article: should NSAID/low-dose aspirin takers be tested routinely for H. pylori infection and treated if positive? Implications for primary risk of ulcer and ulcer relapse after initial healing. (14725573)
2004
29
Genetic differences in interleukin-1 betapolymorphisms among four Asian populations: an analysis of the Asian paradox between H. pylori infection and gastric cancer incidence. (12725322)
2003
30
Distribution of Helicobacter pylori organisms in the stomachs of children with H. pylori infection. (12454819)
2002
31
Seroprevalence of H. pylori infection and symptoms of upper gastrointestinal tract disease in two groups of health-care workers. (11855543)
2002
32
Helicobacter pylori (H pylori) infection in Greece: the changing prevalence during a ten-year period and its antigenic profile. (12014991)
2002
33
Prevalence of H. pylori-infection in family members of H. pylori positive and its influence on the reinfection rate after successful eradication therapy: a two-year follow-up. (12055660)
2002
34
Evaluation of therapeutic efficacy of adjuvant Helicobacter pylori whole cell sonicate in mice with chronic H. pylori infection. (12437028)
2002
35
Gastric epithelial proliferation and p53 and p21 expression in a general population sample: relations to age, sex, and mucosal changes associated with H. pylori infection. (12141817)
2002
36
Clarithromycin resistance, but not CYP2C-19 polymorphism, has a major impact on treatment success in 7-day treatment regimen for cure of H. pylori infection: a multiple logistic regression analysis. (11713950)
2001
37
Gastroenterologists do have a higher risk of acquiring H pylori infection (10894715)
2000
38
Guideline on diagnosis and treatment of H. pylori infection: report from the 6th Annual Meeting of the Japanese Society for Helicobacter Research. (11095142)
2000
39
H pylori infection. Review of the guideline for diagnosis and treatment. (10872345)
2000
40
Reply: An age- and gender-specific analysis of H. pylori infection. (17337993)
1999
41
PPI-based triple therapy in the eradication of H. pylori infection. (10490365)
1999
42
Serology and urea breath test in the diagnosis of H. pylori infection. (10367284)
1999
43
Influence of H. pylori infection on meal-stimulated gastric acid secretion and gastroesophageal acid reflux. (10600812)
1999
44
New stool immunoassay offers routine diagnostic tool for H pylori infection. (10574899)
1999
45
An increased number of follicles containing activated CD69+ helper T cells and proliferating CD71+ B cells are found in H. pylori-infected gastric mucosa. (9576451)
1998
46
Cost-effectiveness of noninvasive testing and treatment strategies for H. pylori infection in children with dyspepsia. (9576448)
1998
47
37 kBq 14C-urea breath test and gastric biopsy analyses of H. pylori infection. (9033373)
1997
48
Pantoprazole versus omeprazole in one-week low-dose triple therapy for curve of H. pylori infection. (9382084)
1997
49
pH and cure of H. pylori infection: it is difficult to have insights when one is in the dark. (7717344)
1995
50
Effect of IL-4 on peripheral blood lymphocyte proliferation: implication in immunopathogenesis of H. pylori infection. (8847090)
1995

Variations for H. Pylori Infection

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Expression for genes affiliated with H. Pylori Infection

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Search GEO for disease gene expression data for H. Pylori Infection.

Pathways for genes affiliated with H. Pylori Infection

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Pathways related to H. Pylori Infection according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL27-mediated signaling events36
9.8IFNGR1, IL1B
29.8IL1B, IFNGR1
3
Show member pathways
IFN-gamma pathway36
9.8IL1B, IFNGR1
4
Show member pathways
IL-1 Signaling Pathway36
IL1-mediated signaling events36
9.7IL1B, IL1RN
59.6CDX2, IL1B
6
Show member pathways
9.4IL1B, IL1RN, IFNGR1

Compounds for genes affiliated with H. Pylori Infection

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Compounds related to H. Pylori Infection according to GeneCards Suite gene sharing:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1anakinra43 1211.1IL1RN, IL1B
2toxin-14310.1IL1RN, IL1B
3gold sodium thiomalate4310.1IL1RN, IL1B
4cuprophan4310.0IL1RN, IL1B
5polysulfone4310.0IL1B, IL1RN
6polymyxin b4310.0IL1B, IL1RN
7leflunomide43 49 1212.0IL1B, IL1RN
8rabeprazole43 49 24 1213.0CYP2C19, IL1B
9chi 24310.0CDH1, IL1RN
10lipoteichoic acid4310.0IL1B, IL1RN
11sulfasalazine28 43 49 1212.9IL1B, IL1RN
12amoxicillin43 49 1211.9CYP2C19, IL1RN
13p00001439.9IL1RN, CDH1
14clarithromycin43 1210.9IL1RN, CYP2C19
15ns 39843 5910.9IL1RN, IL1B
16alginate439.8IL1RN, IL1B
17omeprazole43 49 28 24 1213.8IL1B, CYP2C19
18groalpha439.8IL1B, CXCR1
19etanercept43 49 1211.8IL1B, IL1RN
20propofol43 49 1211.7IL1RN, CYP2C19
21tgf beta1439.7CDH1, IL1B, IL1RN
22hyaluronic acid43 2410.6CDH1, IL1B, IL1RN
23lansoprazole43 49 24 1212.6CYP2C19, IL1RN, IL1B
24aspirin43 49 28 2412.6IL1RN, IL1B, CDH1
25ibuprofen43 28 49 24 1213.6IL1B, IL1RN, CYP2C19
26methotrexate49 43 1211.6CDH1, IL1B, IL1RN
27sb 20358043 5910.6CDH1, IL1B, IL1RN
28troglitazone43 28 59 1212.6CYP2C19, IL1B, CDH1
29leukotriene b443 59 2411.5IL1B, IL1RN, CXCR1
30formaldehyde43 2410.5CDH1, IL1RN, CYP2C19
31histamine43 28 2411.5IL1RN, IL1B, CDH1
32endotoxin439.5IL1B, IL1RN, CXCR1
33fmlp439.5IL1B, IL1RN, CXCR1
34herbimycin a43 5910.4CXCR1, IL1B, CDH1
35rantes439.4IL1B, IL1RN, CXCR1
36il 10439.4IL1RN, IL1B
37vitamin d439.4IL1RN, CDX2, CDH1
38indomethacin43 28 59 1212.2CYP2C19, IL1RN, IL1B, CDH1
39genistein43 28 59 2 24 1214.0CDH1, IL1B, CXCR1
40vegf439.0CXCR1, IL1RN, IL1B, CDH1
41arachidonic acid43 28 24 1211.9CYP2C19, CXCR1, IL1B, CDH1
42oxygen43 249.9CYP2C19, CXCR1, IFNGR1, IL1RN
43cysteine438.7CDH1, CDX2, IL1RN, CXCR1
44paraffin438.6CDH1, CDX2, MUC6
45dexamethasone43 49 28 1211.5CYP2C19, CXCR1, IL1RN, IL1B, CDH1
46retinoic acid43 249.5CDH1, IL1B, IL1RN, CXCR1, CYP2C19
47progesterone43 28 59 24 1212.2CDH1, CDX2, IL1RN, MUC6, CYP2C19
48estrogen438.2CYP2C19, MUC6, IL1RN, CDX2, CDH1
49tyrosine437.7CDH1, CDX2, IL1RN, IFNGR1, CXCR1, PTPRZ1
50calcium43 49 24 1210.6MUC6, CXCR1, IL1RN, CDX2, CDH1

GO Terms for genes affiliated with H. Pylori Infection

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Biological processes related to H. Pylori Infection according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1fever generationGO:00016609.6IL1B, IL1RN
2trophectodermal cell differentiationGO:00018299.2CDH1, CDX2
3positive regulation of transcription, DNA-templatedGO:00458939.1CDH1, CDX2, IL1B

Molecular functions related to H. Pylori Infection according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00051499.7IL1B, IL1RN

Products for genes affiliated with H. Pylori Infection

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Sources for H. Pylori Infection

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet