MCID: HPY002
MIFTS: 43

H. Pylori Infection malady

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Summaries for H. Pylori Infection

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MalaCards based summary: H. Pylori Infection is related to gastritis and gastric cancer risk after h. pylori infection, and has symptoms including An important gene associated with H. Pylori Infection is IFNGR1 (interferon gamma receptor 1), and among its related pathways are Th1 Differentiation and Type II interferon signaling (IFNG). The compounds anakinra and toxin-1 have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and heart, and related mouse phenotypes are tumorigenesis and immune system.

Description from OMIM:46 600263

Aliases & Classifications for H. Pylori Infection

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H. Pylori Infection, Aliases & Descriptions:

Name: H. Pylori Infection 46


Related Diseases for H. Pylori Infection

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Diseases related to H. Pylori Infection via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 84)
idRelated DiseaseScoreTop Affiliating Genes
1gastritis31.5CDX2, IL1RN
2gastric cancer risk after h. pylori infection31.3IL1RN
3atrophic gastritis31.1IL1RN, CDX2
4duodenal ulcer31.1CYP2C19, MUC6, IL1RN
5gastric adenocarcinoma30.9IL1RN, CDX2, CDH1
6esophagitis30.8CYP2C19, CDX2
7stomach cancer30.7CDH1, CDX2
8adenocarcinoma30.6CDH1, CDX2, CXCR1, MUC6
9barrett's esophagus30.6MUC6, CDX2
10colorectal cancer30.2CYP2C19, MUC6, CDX2, CDH1
11gastric cancer10.9
12duodenitis10.7
13dyspepsia10.6
14gastric ulcer10.6
15gastroduodenitis10.6
16degenerative disc disease10.5IL1B
17hereditary diffuse gastric cancer10.5CDH1
18purpura10.5
19dengue shock syndrome10.5IL1RN
20insulin resistance10.4
21chronic infantile neurological cutaneous articular syndrome10.4IL1B, IL1RN
22chorioamnionitis10.4IL1B, IL1RN
23malt lymphoma10.3
24goiter10.3
25pancreatitis10.3
26peptic ulcer disease10.3
27blindness10.3
28cerebral malaria10.3IL1B, IL1RN
29toxic shock syndrome10.3IL1RN, IL1B
30adult respiratory distress syndrome10.3IL1RN, IL1B
31microinvasive gastric cancer10.3CDH1, CDX2
32tubular adenocarcinoma10.3CDX2, CDH1
33periodontitis10.3IL1B, IL1RN
34gallbladder cancer10.3CDX2, CDH1
35malaria10.3IFNGR1
36endometrial carcinoma10.3CDH1, CDX2
37pseudomyxoma peritonei10.3CDX2, MUC6
38neuroendocrine carcinoma10.3CDX2, CDH1
39leishmaniasis10.3IFNGR1
40arthropathy10.3IL1B, IL1RN
41synovitis10.2IL1B, IL1RN
42behcet's disease10.2
43cystic fibrosis10.2
44follicular lymphoma10.2
45hepatitis10.2
46hypertension10.2
47liver disease10.2
48osteoporosis10.2
49irritable bowel syndrome10.2
50cholera10.2

Graphical network of the top 20 diseases related to H. Pylori Infection:



Diseases related to h. pylori infection

Symptoms for H. Pylori Infection

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Symptoms by clinical synopsis from OMIM:

600263

Clinical features from OMIM:

600263

HPO human phenotypes related to H. Pylori Infection:

id Description Frequency HPO Source Accession
1 helicobacter pylori infection HP:0005202

Drugs & Therapeutics for H. Pylori Infection

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Drug clinical trials:

Search ClinicalTrials for H. Pylori Infection

Search NIH Clinical Center for H. Pylori Infection

Genetic Tests for H. Pylori Infection

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Anatomical Context for H. Pylori Infection

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MalaCards organs/tissues related to H. Pylori Infection:

32
Colon, Testes, Heart, Liver, T cells, Monocytes, B cells, Neutrophil

Animal Models for H. Pylori Infection or affiliated genes

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MGI Mouse Phenotypes related to H. Pylori Infection:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.7CDH1, CDX2, IL1B, IFNGR1
2MP:00053878.6CDH1, IL1B, IL1RN, IFNGR1, PTPRZ1
3MP:00053858.1IFNGR1, IL1RN, IL1B, CDX2, CDH1

Publications for H. Pylori Infection

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Articles related to H. Pylori Infection:

(show top 50)    (show all 296)
idTitleAuthorsYear
1
Letter: Bismuth quadruple therapy with Pylera for H. pylori infection. (25123391)
2014
2
CYP2E1 Genetic Polymorphism with Dietary, Tobacco, Alcohol Habits, H. pylori Infection Status and Susceptibility to Stomach Cancer in Mizoram, India. (25374213)
2014
3
Antibiotics resistance of Helicobacter pylori and treatment modalities in children with H. pylori infection. (24678329)
2014
4
Whole-miRNome profiling identifies prognostic serum miRNAs in esophageal adenocarcinoma: the influence of H. pylori infection status. (25381453)
2014
5
Prevalence of H. pylori infection and atrophic gastritis among symptomatic and dyspeptic adults in Kazakhstan. A hospital-based screening study using a panel of serum biomarkers. (24123036)
2013
6
H. pylori infection and gastric cancer: state of the art (review). (23165522)
2013
7
Correlates shift work with increased risk of gastrointestinal complaints or frequency of gastritis or peptic ulcer in H. pylori-infected shift workers? (20012444)
2010
8
Characteristics and interactions of Helicobacter pylori and H. pylori-infected human gastroduodenal epithelium in peptic ulcer: a transmission electron microscopy study. (19160047)
2010
9
The reliability of ELISA in predicting H. pylori infection in dyspeptic populations under age 45. (20037501)
2010
10
The BB genotype of heat-shock protein (HSP) 70-2 gene is associated with gastric pre-malignant condition in H. pylori-infected older patients. (19661373)
2009
11
Endoscopic and histopathologic findings associated with H. pylori infection in very young children. (18594977)
2009
12
Retractions. Re: "Ethics of administering gatifloxacin for H. pylori infection in asymptomatic veterans" by D. Vaira, A. Zullo, V. de Francesco, G. Scaccianoce and "Ethical issues regarding recent anti-H. pylori clinical studies" by D. Y. Graham . (18194502)
2008
13
CpG island hypermethylation of tumor-suppressor genes in H. pylori-infected non-neoplastic gastric mucosa is linked with gastric cancer risk. (18205664)
2008
14
E-cadherin promoter hypermethylation induced by interleukin-1beta treatment or H. pylori infection in human gastric cancer cell lines. (18249489)
2008
15
Aberrant DNA methylation in non-neoplastic gastric mucosa of H. Pylori infected patients and effect of eradication. (17509026)
2007
16
Review: eradication therapy supplemented by probiotics increased eradication rates and reduced side effects in H. pylori infection. (17474672)
2007
17
Clinical role and importance of fluorescence in situ hybridization method in diagnosis of H pylori infection and determination of clarithromycin resistance in H pylori eradication therapy. (17278188)
2007
18
Genetic variants in matrix metalloproteinase genes are associated with development of gastric ulcer in H. Pylori infection. (16405530)
2006
19
Short mucin 6 alleles are associated with H pylori infection. (17009402)
2006
20
What is the most sensitive non-invasive test for initial diagnosis of H. pylori infection in adults? (16821494)
2006
21
Comparison of invasive methods and two different stool antigen tests for diagnosis of H pylori infection in patients with gastric bleeding. (16830376)
2006
22
Insulin resistance in H pylori infection and its association with oxidative stress. (17106938)
2006
23
Efficacy of sonicated and acid-extractable antigens in the serodiagnosis of H. pylori infection in peptic ulcer patients. (15928442)
2005
24
Poliovirus replicons encoding the B subunit of Helicobacter pylori urease protect mice against H. pylori infection. (15603891)
2005
25
Does H. Pylori infection play a role in idiopathic thrombocytopenic purpura and in other autoimmune diseases? (15929756)
2005
26
Levofloxacin- versus metronidazole-based rescue therapy for H. pylori infection in Japan. (16040284)
2005
27
Review article: should NSAID/low-dose aspirin takers be tested routinely for H. pylori infection and treated if positive? Implications for primary risk of ulcer and ulcer relapse after initial healing. (14725573)
2004
28
Genetic differences in interleukin-1 betapolymorphisms among four Asian populations: an analysis of the Asian paradox between H. pylori infection and gastric cancer incidence. (12725322)
2003
29
Distribution of Helicobacter pylori organisms in the stomachs of children with H. pylori infection. (12454819)
2002
30
Seroprevalence of H. pylori infection and symptoms of upper gastrointestinal tract disease in two groups of health-care workers. (11855543)
2002
31
Helicobacter pylori (H pylori) infection in Greece: the changing prevalence during a ten-year period and its antigenic profile. (12014991)
2002
32
Prevalence of H. pylori-infection in family members of H. pylori positive and its influence on the reinfection rate after successful eradication therapy: a two-year follow-up. (12055660)
2002
33
Evaluation of therapeutic efficacy of adjuvant Helicobacter pylori whole cell sonicate in mice with chronic H. pylori infection. (12437028)
2002
34
Gastric epithelial proliferation and p53 and p21 expression in a general population sample: relations to age, sex, and mucosal changes associated with H. pylori infection. (12141817)
2002
35
Clarithromycin resistance, but not CYP2C-19 polymorphism, has a major impact on treatment success in 7-day treatment regimen for cure of H. pylori infection: a multiple logistic regression analysis. (11713950)
2001
36
Gastroenterologists do have a higher risk of acquiring H pylori infection (10894715)
2000
37
Guideline on diagnosis and treatment of H. pylori infection: report from the 6th Annual Meeting of the Japanese Society for Helicobacter Research. (11095142)
2000
38
H pylori infection. Review of the guideline for diagnosis and treatment. (10872345)
2000
39
Reply: An age- and gender-specific analysis of H. pylori infection. (17337993)
1999
40
PPI-based triple therapy in the eradication of H. pylori infection. (10490365)
1999
41
Serology and urea breath test in the diagnosis of H. pylori infection. (10367284)
1999
42
Influence of H. pylori infection on meal-stimulated gastric acid secretion and gastroesophageal acid reflux. (10600812)
1999
43
New stool immunoassay offers routine diagnostic tool for H pylori infection. (10574899)
1999
44
An increased number of follicles containing activated CD69+ helper T cells and proliferating CD71+ B cells are found in H. pylori-infected gastric mucosa. (9576451)
1998
45
Cost-effectiveness of noninvasive testing and treatment strategies for H. pylori infection in children with dyspepsia. (9576448)
1998
46
37 kBq 14C-urea breath test and gastric biopsy analyses of H. pylori infection. (9033373)
1997
47
Pantoprazole versus omeprazole in one-week low-dose triple therapy for curve of H. pylori infection. (9382084)
1997
48
Should we treat H. pylori infection to prevent gastric cancer? (9041272)
1997
49
pH and cure of H. pylori infection: it is difficult to have insights when one is in the dark. (7717344)
1995
50
Effect of IL-4 on peripheral blood lymphocyte proliferation: implication in immunopathogenesis of H. pylori infection. (8847090)
1995

Variations for H. Pylori Infection

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Expression for genes affiliated with H. Pylori Infection

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Expression patterns in normal tissues for genes affiliated with H. Pylori Infection

Search GEO for disease gene expression data for H. Pylori Infection.

Pathways for genes affiliated with H. Pylori Infection

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Pathways related to H. Pylori Infection according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
IL27-mediated signaling events37
9.8IFNGR1, IL1B
29.8IL1B, IFNGR1
3
Show member pathways
IFN-gamma pathway37
9.8IL1B, IFNGR1
4
Show member pathways
IL-1 Signaling Pathway37
IL1-mediated signaling events37
9.7IL1B, IL1RN
59.6CDX2, IL1B
69.6IL1B, CYP2C19
79.5CDH1, CDX2
8
Show member pathways
9.4IL1B, IL1RN, IFNGR1

Compounds for genes affiliated with H. Pylori Infection

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Compounds related to H. Pylori Infection according to GeneCards/GeneDecks:

(show top 50)    (show all 61)
idCompoundScoreTop Affiliating Genes
1anakinra44 1111.1IL1RN, IL1B
2toxin-14410.1IL1RN, IL1B
3gold sodium thiomalate4410.1IL1RN, IL1B
4cuprophan4410.0IL1RN, IL1B
5polysulfone4410.0IL1B, IL1RN
6polymyxin b4410.0IL1B, IL1RN
7leflunomide44 50 1112.0IL1B, IL1RN
8rabeprazole44 50 24 1113.0CYP2C19, IL1B
9chi 24410.0CDH1, IL1RN
10lipoteichoic acid4410.0IL1B, IL1RN
11sulfasalazine28 44 50 1112.9IL1B, IL1RN
12amoxicillin44 50 1111.9CYP2C19, IL1RN
13p00001449.9IL1RN, CDH1
14clarithromycin44 1110.9IL1RN, CYP2C19
15ns 39844 6110.9IL1RN, IL1B
16alginate449.8IL1RN, IL1B
17omeprazole44 50 28 24 1113.8IL1B, CYP2C19
18groalpha449.8IL1B, CXCR1
19etanercept44 50 1111.8IL1B, IL1RN
20propofol44 50 1111.7IL1RN, CYP2C19
21tgf beta1449.7CDH1, IL1B, IL1RN
22hyaluronic acid44 2410.6CDH1, IL1B, IL1RN
23lansoprazole44 50 24 1112.6CYP2C19, IL1RN, IL1B
24aspirin44 50 28 2412.6IL1RN, IL1B, CDH1
25ibuprofen44 28 50 24 1113.6IL1B, IL1RN, CYP2C19
26methotrexate50 44 1111.6CDH1, IL1B, IL1RN
27sb 20358044 6110.6CDH1, IL1B, IL1RN
28troglitazone44 28 61 1112.6CYP2C19, IL1B, CDH1
29leukotriene b444 61 2411.5IL1B, IL1RN, CXCR1
30formaldehyde44 2410.5CDH1, IL1RN, CYP2C19
31histamine44 28 2411.5IL1RN, IL1B, CDH1
32endotoxin449.5IL1B, IL1RN, CXCR1
33fmlp449.5IL1B, IL1RN, CXCR1
34herbimycin a44 6110.4CXCR1, IL1B, CDH1
35rantes449.4IL1B, IL1RN, CXCR1
36il 10449.4IL1RN, IL1B
37vitamin d449.4IL1RN, CDX2, CDH1
38indomethacin44 28 61 1112.2CYP2C19, IL1RN, IL1B, CDH1
39genistein44 28 61 2 24 1114.0CDH1, IL1B, CXCR1
40vegf449.0CXCR1, IL1RN, IL1B, CDH1
41arachidonic acid44 28 24 1111.9CYP2C19, CXCR1, IL1B, CDH1
42oxygen44 249.9CYP2C19, CXCR1, IFNGR1, IL1RN
43cysteine448.7CDH1, CDX2, IL1RN, CXCR1
44paraffin448.6CDH1, CDX2, MUC6
45dexamethasone44 50 28 1111.5CYP2C19, CXCR1, IL1RN, IL1B, CDH1
46retinoic acid44 249.5CDH1, IL1B, IL1RN, CXCR1, CYP2C19
47progesterone44 28 61 24 1112.2CDH1, CDX2, IL1RN, MUC6, CYP2C19
48estrogen448.2CYP2C19, MUC6, IL1RN, CDX2, CDH1
49tyrosine447.7CDH1, CDX2, IL1RN, IFNGR1, CXCR1, PTPRZ1
50calcium44 50 24 1110.6MUC6, CXCR1, IL1RN, CDX2, CDH1

GO Terms for genes affiliated with H. Pylori Infection

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Biological processes related to H. Pylori Infection according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fever generationGO:0016609.6IL1B, IL1RN
2trophectodermal cell differentiationGO:0018299.2CDH1, CDX2
3positive regulation of transcription, DNA-templatedGO:0458939.1CDH1, CDX2, IL1B

Molecular functions related to H. Pylori Infection according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:0051499.7IL1B, IL1RN

Products for genes affiliated with H. Pylori Infection

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Sources for H. Pylori Infection

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet