MCID: HPY002
MIFTS: 52

H. Pylori Infection malady

Summaries for H. Pylori Infection

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47OMIM, 33MalaCards
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MalaCards: H. Pylori Infection, also known as helicobacter pylori infection, is related to duodenal ulcer and dyspepsia. An important gene associated with H. Pylori Infection is IFNGR1 (interferon gamma receptor 1), and among its related pathways are Th17 Differentiation and Cell adhesion ECM remodeling. The compounds estrogen and hbd2 have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lymph node and spinal cord, and related mouse phenotypes are skeleton and tumorigenesis.

Description from OMIM:47 600263

Aliases & Classifications for H. Pylori Infection

Sources:
47OMIM, 61UMLS
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Aliases & Descriptions:

h. pylori infection 47
helicobacter pylori infection 61


Related Diseases for H. Pylori Infection

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to H. Pylori Infection via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 213)
idRelated DiseaseScoreTop Affiliating Genes
1duodenal ulcer31.0S100A8, GAST, IL1RN
2dyspepsia30.9GAST
3gastric ulcer30.9S100A8, GAST
4duodenitis30.9S100A8, GAST
5gastroesophageal reflux disease30.9GAST, S100A8
6asthma30.8CXCR1, CXCR2, DEFB4A, S100A8, CXCL1, IL12B
7squamous cell carcinoma30.7S100A8, DEFB4A, MUC6, CDX2, CXCR2, CXCR1
8adenocarcinoma30.7F2RL1, MMP7, CXCR1, CXCR2, CDX2, MUC6
9gastroduodenitis30.6GAST
10graves' disease30.6IL1RN, IL12B
11barrett's esophagus30.6S100A8, GAST, MUC6, CDX2
12adenoma30.6S100A8, GAST, MUC6, CDX2, CXCL1, MMP7
13atrophic gastritis30.6S100A8, GAST, CDX2, IL1RN
14uveitis30.5CXCR1
15typhoid fever30.5IFNGR1
16hepatitis c30.5IL12B, MMP7
17atherosclerosis30.5CXCR2, CXCR1, CXCL1, IL12B, IL1RN, IL1B
18ulcerative colitis30.5F2RL1, MMP7, MMP3, DEFB103B, DEFB4A, CXCR2
19gastric cancer risk after h. pylori infection30.5IL1B, IL1RN
20colorectal cancer30.4S100A8, GAST, MUC6, CDX2, CXCR2, IL1RN
21lichen planus30.3DEFB4A
22familial mediterranean fever30.3IL1B
23atopy30.3IL12B
24acute pancreatitis30.3F2RL1, IL1RN
25tuberculosis30.3IFNGR1, DEFB4A, CXCR2, CXCR1, IL12B, IL1B
26arthritis30.3S100A8, CXCR2, CXCR1, CXCL1, IL1RN, IL1B
27sjogren's syndrome30.2S100A8
28stomach cancer30.2CDX2, GAST
29irritable bowel syndrome30.2F2RL1
30cystic fibrosis30.2S100A8, DEFB103B, DEFB4A, MUC6, CXCR1, F2RL1
31deficiency anemia10.7
32iron deficiency anemia10.7
33duodenogastric reflux10.6
34pernicious anemia10.6
35bile reflux10.6
36gastric cardia adenocarcinoma10.6
37lymphocytic gastritis10.6
38allergic asthma10.5
39primary open angle glaucoma10.5
40giardiasis10.5
41thyroiditis10.5
42autoimmune thyroiditis10.4
43primary biliary cirrhosis10.4
44cardia cancer10.4
45zollinger-ellison syndrome10.4
46angioedema10.4
47gastric lymphoma10.4
48insulin resistance10.4
49axonal neuropathy10.4
50pharyngitis10.4

Graphical network of the top 20 diseases related to H. Pylori Infection:



Diseases related to h. pylori infection

Clinical Features for H. Pylori Infection

Sources:
47OMIM
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Clinical features from OMIM:

600263

Clinical synopsis from OMIM:

600263

Drugs & Therapeutics for H. Pylori Infection

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for H. Pylori Infection

Drug clinical trials:

Search ClinicalTrials for H. Pylori Infection

Search NIH Clinical Center for H. Pylori Infection

Search CenterWatch for H. Pylori Infection

Genetic Tests for H. Pylori Infection

Anatomical Context for H. Pylori Infection

Sources:
33MalaCards
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MalaCards organs/tissues related to H. Pylori Infection:

33
Whole blood, Lymph node, Spinal cord, Heart, Small intestine, Colon, Liver, Thyroid, Myeloid, T cells, B cells, Endothelial, Fetal liver, Fetal thyroid

Animal Models for H. Pylori Infection or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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Publications for H. Pylori Infection

Sources:
51PubMed
See all sources

Articles related to H. Pylori Infection:

(show top 50)    (show all 929)
idTitleAuthorsYear
1
Iron deficiency anemia due to lymphocytic gastritis with Helicobacter pylori infection in childhood: case report. (23528908)
2013
2
Helicobacter pylori Infection and Anemia in Taiwanese Adults. (24348534)
2013
3
Active Helicobacter pylori infection is associated with colorectal mucosa - adenomatous polyp - early and advanced adenocarcinoma sequence. (24299055)
2013
4
Meta-analysis: eradication of Helicobacter pylori infection is associated with the development of endoscopic gastroesophageal reflux disease. (23839160)
2013
5
Analysis of the association of interleukin-17 gene polymorphisms with gastric cancer risk and interaction with Helicobacter pylori infection in a Chinese population. (24218334)
2013
6
Granulomatous gastritis and Helicobacter pylori infection. (23882902)
2013
7
Assessment of risk factors of helicobacter pylori infection and peptic ulcer disease. (23853433)
2013
8
Assessment of desmosomal components (desmoglein 1-3, plakoglobin) in cardia mucosa in relation to gastroesophageal reflux disease and Helicobacter pylori infection. (22521077)
2012
9
Nodular gastritis: an endoscopic indicator of Helicobacter pylori infection in children. (23197056)
2012
10
Genetic polymorphism of XRCC3 codon 241 and Helicobacter pylori infection-related gastric antrum adenocarcinoma in Guangxi Population, China: a hospital-based case-control study. (21937297)
2011
11
Helicobacter pylori: H. pylori infection might suppress allergy in children. (21818139)
2011
12
Expression of hnRNPK in gastric carcinoma and its relationship with Helicobacter pylori L-form infection]. (22335908)
2011
13
Effects of Helicobacter pylori infection on the expressions of Bax and Bcl-2 in patients with chronic gastritis and gastric cancer. (19160045)
2010
14
Association of Helicobacter pylori infection with systemic inflammation in preeclampsia. (20222830)
2010
15
Genetic polymorphism in chemokine CCL22 and susceptibility to Helicobacter pylori infection-related gastric carcinoma. (19298002)
2009
16
Toll-like receptor (TLR2, TLR4 and TLR5) gene polymorphisms and Helicobacter pylori infection in children with and without duodenal ulcer. (18809506)
2008
17
Expression of COX-1, COX-2, and PPAR-gamma in the gastric mucosa of children with Helicobacter pylori infection. (18279196)
2008
18
Analysis of Pro12Ala PPAR gamma polymorphism and Helicobacter pylori infection in gastric adenocarcinoma and peptic ulcer disease. (18372284)
2008
19
Helicobacter pylori infection as a triggering factor of attacks in patients with hereditary angioedema. (17493006)
2007
20
Increased interleukin-10 in Helicobacter pylori infection could be involved in the mechanism protecting from allergy. (17873741)
2007
21
Role of CD14 promoter polymorphisms in Helicobacter pylori infection--related gastric carcinoma. (17438094)
2007
22
Effect of MDR1 C3435T polymorphism on cure rates of Helicobacter pylori infection by triple therapy with lansoprazole, amoxicillin and clarithromycin in relation to CYP 2C19 genotypes and 23S rRNA genotypes of H. pylori. (17697203)
2007
23
Is GastroPanel serum assay useful in the diagnosis of Helicobacter pylori infection and associated gastritis in children? (16949782)
2007
24
The influence of serum 25-hydroxy vitamin D levels on Helicobacter Pylori Infections in patients with end-stage renal failure on regular hemodialysis. (17496397)
2007
25
Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor: critical regulators of beta-defensins during Helicobacter pylori infection. (16513653)
2006
26
Helicobacter pylori infection, but not mucosal atrophy, significantly affects serum pepsinogen level after gastric cancer surgery. (16995475)
2006
27
Standard treatment for Helicobacter pylori infection is suboptimal in non-ulcer dyspepsia compared with duodenal ulcer in Chinese. (15644048)
2005
28
Clinical value of Helicobacter pylori stool antigen test, ImmunoCard STAT HpSA, for detecting H pylori infection. (15040045)
2004
29
Alteration of E-cadherin expression in gastric mucosa: role of intestinal metaplasia and Helicobacter pylori infection. (15274329)
2004
30
Relationship of sliding hiatus hernia to gastroesophageal reflux disease: a possible role for Helicobacter pylori infection? (12643607)
2003
31
Perforin and granzyme B of cytotoxic T lymphocyte mediate apoptosis irrespective of Helicobacter pylori infection: possible act as a trigger of peptic ulcer formation. (14696402)
2003
32
Prevalence of low vitamin B12 and high homocysteine in serum in an elderly male population: association with atrophic gastritis and Helicobacter pylori infection. (14750639)
2003
33
Is antimicrobial susceptibility testing necessary before second-line treatment for Helicobacter pylori infection? (12823158)
2003
34
Relation between helicobacter pylori L-form infection and tumor angiogenesis in human esophageal carcinoma]. (12678988)
2003
35
Cytoskeletal rearrangements in gastric epithelial cells in response to Helicobacter pylori infection. (12972579)
2003
36
Expression of surfactant protein D in the human gastric mucosa and during Helicobacter pylori infection. (11854236)
2002
37
p53 mutation pattern and expression of c-erbB2 and c-met in gastric cancer: relation to histological subtypes, Helicobacter pylori infection, and prognosis. (11837710)
2002
38
Associations of food-cobalamin malabsorption with ethnic origin, age, Helicobacter pylori infection, and serum markers of gastritis. (11197289)
2001
39
Low incidence of Helicobacter pylori infection in patients with duodenal ulcer and chronic liver disease. (11346200)
2001
40
Effects of CYP2C19 gene polymorphism on cure rates for Helicobacter pylori infection by triple therapy with proton pump inhibitor (omeprazole or rabeprazole), amoxycillin and clarithromycin in Japan. (11785712)
2001
41
Epithelial and bacterial metalloproteinases and their inhibitors in H. pylori infection of human gastric cells. (11518695)
2001
42
Heat shock protein 70 (HSP70) in gastric adaptation to aspirin in Helicobacter pylori infection. (11321509)
2001
43
Antigastric autoantibodies in Helicobacter pylori infection: role in gastric mucosal inflammation. (11289707)
2000
44
Micronutrient antioxidants in gastric mucosa and serum in patients with gastritis and gastric ulcer: does Helicobacter pylori infection affect the mucosal levels? (10875465)
2000
45
The rise in circulating gastrin with age is due to increases in gastric autoimmunity and Helicobacter pylori infection. (10627886)
1999
46
Histological and functional recovery in patients with multifocal atrophic gastritis after eradication of Helicobacter pylori infection. (10091096)
1999
47
The role of the HLA-DQA1 gene in resistance to atrophic gastritis and gastric adenocarcinoma induced by Helicobacter pylori infection. (9506344)
1998
48
History of antibiotic treatment and prevalence of H. pylori infection among children: results of a population-based study. (9495692)
1998
49
Genetic alterations in gastric cancer: relation to histological subtypes, tumor stage, and Helicobacter pylori infection. (9136822)
1997
50
Helicobacter pylori infection: physiopathologic implication of N alpha-methyl histamine. (7698611)
1995

Genetic Variations for H. Pylori Infection

Expression for genes affiliated with H. Pylori Infection

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with H. Pylori Infection

Search GEO for disease gene expression data for H. Pylori Infection.

Pathways for genes affiliated with H. Pylori Infection

Sources:
53R&D Systems, 12EMD Millipore, 52QIAGEN, 38NCBI BioSystems Database, 30KEGG, 54Reactome
See all sources

Pathways related to H. Pylori Infection according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4IL17F
2
Cell adhesion ECM remodeling
Hide members
10.3MMP3, MMP7
310.2IL12B, IL12A, IL1B
4
Hide members
10.2IL12B, IL12A, IL1B
510.2IL12B, IL12A, IL1B
610.2IL1B, IL12A, IL12B
710.2IL1B, CXCL1, IFNGR1
810.2IL1B, IL12B, CXCL1
9
Cytokine production by Th17 cells in CF (Mouse model)
10.2CXCL1, IL12B, IL17F
10
Immune response Bacterial infections in normal airways
Hide members
10.2IFNGR1, DEFB4A, IL1RN, IL1B
11
Hide members
10.1IFNGR1, IL12B, IL12A, IL1B
12
Hide members
10.1IL1B, IL12A, IL12B, IFNGR1
1310.1IL1B, IL12A, IL12B, IFNGR1
1410.1CXCL1, CXCR1, CXCR2
1510.1IL12B, IL12A, IL1B, F2RL1
16
Development PDGF signaling via STATs and NF-kB
Hide members
10.1IL1B, IL17F, IL12B, CXCL1
17
Hide members
10.1PTPRZ1, IL12A, IL12B, CXCL1
1810.1CXCL1, IL12B, IL12A, IL1B
19
Hide members
10.1CXCR2, CXCR1, CXCL1, PTPRZ1
20
Hide members
10.0HSPA2, IFNGR1, IL12B, IL12A, IL1B
21
Hide members
10.0IL1B, IL12A, IL12B, IFNGR1, HSPA2
22
Hide members
10.0IFNGR1, CXCR2, CXCR1, CXCL1, IL12A
2310.0IL1B, IL12A, IL12B, CXCL1, HSPA2
24
Hide members
9.9HSPA2, IFNGR1, IL12B, IL12A, IL17F, IL1B

Compounds for genes affiliated with H. Pylori Infection

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 29IUPHAR, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to H. Pylori Infection according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1estrogen4510.8DEFB4A
2hbd24510.5DEFB103B, DEFB4A, IL1B
3grogamma4510.5CXCR2, CXCR1, CXCL1
4amoxicillin45 50 1112.5S100A8, GAST, IL1RN
5[125i]cxcl8 (human)2910.5CXCR1, CXCR2
6peptidoglycan45 2911.5DEFB4A, IL1B, IL1RN, IL12B
7flagellin45 2911.5S100A8, DEFB4A, IL1B
8cxcl12910.5CXCR2, CXCR1
9grobeta4510.5CXCR2, CXCR1, CXCL1
10prostaglandin4510.5IL1RN, MMP7, MMP3, IL1B
11cxcl82910.5CXCR1, CXCR2
12fmlp4510.5CXCL1, F2RL1, IL1RN, CXCR2
13infliximab45 50 1112.5MMP3, IL1B, IL1RN, CXCL1
145 aminosalicylic acid4510.5CXCL1, IL1B, IL12B
15groalpha4510.5CXCL1, CXCR1, IL1B, CXCR2
16cxcl62910.5CXCR1, CXCR2
17clarithromycin45 1111.5S100A8, IL1RN, GAST
18lipoteichoic acid4510.4IL1B, IL1RN, IL12B, CXCR2, DEFB4A
19sulfasalazine45 29 50 1113.4IL12B, MMP3, IL1B, CXCL1, IL1RN
20dexamethasone45 50 29 1113.4CXCL1, CXCR1, DEFB4A, DEFB103B, S100A8
21endotoxin4510.4CXCR2, DEFB4A, CXCL1, S100A8, F2RL1
22oxygen45 2411.4S100A8, IFNGR1, CXCR1, CXCR2, F2RL1
23leflunomide50 45 1112.3MMP3, IL1B, IL1RN
24ribonucleic acid4510.3IL1RN, IL1B, MMP7, MMP3, CXCL1
25leukotriene b445 60 2412.3IL1B, CXCR2, CXCR1, F2RL1, CXCL1, IL1RN
26methotrexate45 50 1112.3MMP3, IL1B, IL1RN, CXCL1, S100A8
27alginate4510.3IL1RN, MMP3, IL1B
28pd 98,0594510.3F2RL1, CXCL1, DEFB4A, MMP3, IL12B, IL1B
29p0024510.3IL1RN, MMP3, MMP7, DEFB4A
30heparin45 29 11 2413.3F2RL1, CXCR2, MMP3, CXCL1, DEFB4A, IL1RN
31genistein45 29 60 2 11 2415.2IL1B, F2RL1, DEFB4A, CXCR2, CXCR1, MMP3
32rantes4510.2DEFB4A, S100A8, CXCR1, CXCL1, IL12B, IL1B
33etanercept45 50 1112.2IL1RN, MMP3, IL1B
34paraffin4510.2MMP3, MMP7, DEFB4A, CDX2, MUC6, S100A8
35superoxide45 2411.2S100A8, CXCR1, CXCL1, CXCR2, F2RL1, IL1B
36vitamin d4510.2CDX2, IL12B, IL1RN, MMP3, GAST
37sb 20358045 6011.1DEFB4A, CXCL1, IL12B, IL1RN, IL1B, MMP3
38progesterone45 60 29 11 2414.1MUC6, DEFB4A, CDX2, CXCL1, MMP7, MMP3
39histamine45 29 2412.1F2RL1, CXCL1, S100A8, GAST, DEFB4A, IL1RN
40oligonucleotide4510.1S100A8, CDX2, F2RL1, MMP7, CXCL1, CXCR1
41nitric oxide45 11 2412.1S100A8, MMP7, CXCL1, IL12B, IL1RN, IL1B
42vegf4510.0GAST, IL1B, MMP3, CXCR1, MMP7, CXCL1
43retinoic acid45 2411.0MMP7, CXCR1, IL1B, IL1RN, CXCL1, DEFB4A
44lipid459.9IL1RN, F2RL1, IL12B, MMP3, CXCR1, CXCR2
45il 10459.9IL1B, IL1RN, IL12B
46phosphatidylinositol459.9CXCR1, IL12B, IL1RN, MMP7, CXCR2, F2RL1
47cysteine459.8CXCR1, CXCL1, IL1RN, MMP7, F2RL1, CXCR2
48serine459.7F2RL1, MMP3, IL1RN, CXCL1, CXCR2, S100A8
49tyrosine459.7MMP7, CXCL1, MMP3, CDX2, CXCR1, IL1RN
50calcium45 50 11 2412.5CXCR2, S100A8, GAST, DEFB103B, DEFB4A, CDX2

GO Terms for genes affiliated with H. Pylori Infection

Sources:
16Gene Ontology
See all sources

Cellular components related to H. Pylori Infection according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-12 complexGO:04351410.3IL12A, IL12B
2extracellular spaceGO:0056159.5MMP3, IL1B, IL17F, IL1RN, IL12A, IL12B
3extracellular regionGO:0055769.3MMP7, S100A8, MMP3, IL1B, IL17F, CXCL1

Biological processes related to H. Pylori Infection according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1interleukin-8-mediated signaling pathwayGO:03811210.6CXCR2, CXCR1
2positive regulation of tyrosine phosphorylation of Stat4 proteinGO:04252010.6IL12A, IL12B
3positive regulation of NK T cell activationGO:05113510.5IL12A, IL12B
4positive regulation of interferon-gamma productionGO:03272910.5IL1B, IL12A, IL12B
5positive regulation of lymphocyte proliferationGO:05067110.5IL12B, IL12A
6positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272510.5IL12B, IL1B
7positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetGO:00286010.5IL12B, IL12A
8positive regulation of T cell proliferationGO:04210210.5IL12B, IL12A, IL1B
9neutrophil chemotaxisGO:03059310.5S100A8, CXCR2, IL1B
10positive regulation of natural killer cell activationGO:03281610.4IL12A, IL12B
11positive regulation of smooth muscle cell apoptotic processGO:03439310.4IL12A, IL12B
12chemotaxisGO:00693510.4CXCL1, CXCR1, CXCR2, DEFB4A
13negative regulation of interleukin-17 productionGO:03270010.4IL12B, IL12A
14immune responseGO:00695510.3DEFB4A, CXCL1, IL12A, IL1RN, IL1B
15response to UV-BGO:01022410.3IL12A, IL12B
16G-protein coupled receptor signaling pathwayGO:00718610.3GAST, DEFB4A, CXCR1, CXCL1, F2RL1
17dendritic cell chemotaxisGO:00240710.3CXCR1, CXCR2
18neutrophil activationGO:04211910.2F2RL1, CXCR2
19inflammatory responseGO:00695410.1F2RL1, IL1B, IL17F, CXCL1, CXCR1, CXCR2
20regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312210.0F2RL1, IL1B

Molecular functions related to H. Pylori Infection according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00514910.3IL1B, IL1RN
2interleukin-8 receptor activityGO:00491810.3CXCR1, CXCR2
3interleukin-8 bindingGO:01995910.3CXCR1, CXCR2
4cytokine activityGO:00512510.0IL12A, IL12B, IL17F, IL1B
5interleukin-12 receptor bindingGO:00514310.0IL12B, IL12A

Products for genes affiliated with H. Pylori Infection

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for H. Pylori Infection

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet