MCID: HPY002
MIFTS: 39

H. Pylori Infection malady

Summaries for H. Pylori Infection

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46OMIM, 32MalaCards
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MalaCards: H. Pylori Infection, also known as helicobacter pylori infection, is related to duodenitis and duodenal ulcer. An important gene associated with H. Pylori Infection is IFNGR1 (interferon gamma receptor 1), and among its related pathways are Th17 Differentiation and Cell adhesion ECM remodeling. The compounds estrogen and hbd2 have been mentioned in the context of this disorder. Affiliated tissues include colon, and related mouse phenotypes are skeleton and tumorigenesis.

Description from OMIM:46 600263

Aliases & Classifications for H. Pylori Infection

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46OMIM, 60UMLS
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Aliases & Descriptions:

h. pylori infection 46
helicobacter pylori infection 60


Related Diseases for H. Pylori Infection

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17GeneCards, 18GeneDecks
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Diseases related to H. Pylori Infection via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 241)
idRelated DiseaseScoreTop Affiliating Genes
1duodenitis31.0S100A8, GAST
2duodenal ulcer31.0S100A8, GAST, IL1RN
3peptic ulcer30.9CXCL1, GAST, S100A8
4gastritis30.9S100A8, GAST, DEFB4A, CDX2, IL1RN
5dyspepsia30.8GAST
6gastric ulcer30.8S100A8, GAST
7gastroesophageal reflux disease30.8GAST, S100A8
8gastroduodenitis30.8GAST
9asthma30.7CXCR1, CXCR2, DEFB4A, S100A8, CXCL1, IL12B
10squamous cell carcinoma30.7S100A8, DEFB4A, MUC6, CDX2, CXCR2, CXCR1
11gastric adenocarcinoma30.6S100A8, GAST, DEFB4A, CDX2, IL1RN, MMP7
12adenocarcinoma30.6F2RL1, MMP7, CXCR1, CXCR2, CDX2, MUC6
13graves' disease30.6IL1RN, IL12B
14diabetes mellitus30.6MMP3, IL1B
15pancreatitis30.5IL1B, F2RL1
16atrophic gastritis30.5S100A8, GAST, CDX2, IL1RN
17uveitis30.5CXCR1
18typhoid fever30.5IFNGR1
19hepatitis c30.5IL12B, MMP7
20pancreatic cancer30.5GAST, MUC6, CDX2, F2RL1
21atherosclerosis30.4CXCR2, CXCR1, CXCL1, IL12B, IL1RN, IL1B
22ulcerative colitis30.4F2RL1, MMP7, MMP3, DEFB103B, DEFB4A, CXCR2
23gastric cancer risk after h. pylori infection30.4IL1B, IL1RN
24colorectal cancer30.4S100A8, GAST, MUC6, CDX2, CXCR2, IL1RN
25peritonitis30.2IL1B
26lichen planus30.2DEFB4A
27familial mediterranean fever30.2IL1B
28acute pancreatitis30.2F2RL1, IL1RN
29leukemia30.2S100A8, CDX2, CXCR1, CXCL1, IL12B, IL1B
30tuberculosis30.2IFNGR1, DEFB4A, CXCR2, CXCR1, IL12B, IL1B
31adenoma30.2S100A8, GAST, MUC6, CDX2, CXCL1, MMP7
32colon cancer30.2GAST, CDX2, CXCR2, CXCR1, CXCL1, MMP7
33arthritis30.2S100A8, CXCR2, CXCR1, CXCL1, IL1RN, IL1B
34encephalitis30.2IL1B, IL12B
35multiple sclerosis30.2IFNGR1, S100A8, CXCR2, CXCR1, CXCL1, IL12B
36rheumatoid arthritis30.2S100A8, CXCR2, CXCR1, CXCL1, IL12B, IL1RN
37sjogren's syndrome30.2S100A8
38stomach cancer30.2CDX2, GAST
39esophagitis30.2CDX2, GAST, S100A8
40barrett's esophagus30.2S100A8, GAST, MUC6, CDX2
41irritable bowel syndrome30.2F2RL1
42cystic fibrosis30.2S100A8, DEFB103B, DEFB4A, MUC6, CXCR1, F2RL1
43deficiency anemia10.7
44iron deficiency anemia10.7
45duodenogastric reflux10.6
46pernicious anemia10.6
47laryngitis10.6
48bile reflux10.5
49lymphocytic gastritis10.5
50neuropathy10.5

Graphical network of the top 20 diseases related to H. Pylori Infection:



Diseases related to h. pylori infection

Clinical Features for H. Pylori Infection

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46OMIM
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Clinical features from OMIM:

600263

Clinical synopsis from OMIM:

600263

Drugs & Therapeutics for H. Pylori Infection

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for H. Pylori Infection

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Anatomical Context for H. Pylori Infection

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32MalaCards
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MalaCards organs/tissues related to H. Pylori Infection:

32
Colon

Animal Models for H. Pylori Infection or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to H. Pylori Infection:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539010.1IFNGR1, CDX2, IL17F, IL1B, MMP3
2MP:000200610.0MMP7, IL1B, IL12B, CXCR2, GAST, IFNGR1
3MP:00053859.7CDX2, CXCR2, CXCL1, IL1RN, IL1B, MMP7
4MP:00053879.5IL12A, IL12B, CXCR2, GAST, IFNGR1, IL1RN
5MP:00107689.3IFNGR1, S100A8, GAST, CDX2, CXCR2, IL12B
6MP:00053769.2IFNGR1, GAST, CDX2, CXCR2, IL12B, IL12A

Publications for H. Pylori Infection

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Genetic Variations for H. Pylori Infection

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Expression for genes affiliated with H. Pylori Infection

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with H. Pylori Infection

Search GEO for disease gene expression data for H. Pylori Infection.

Pathways for genes affiliated with H. Pylori Infection

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52R&D Systems, 12EMD Millipore, 51QIAGEN, 37NCBI BioSystems Database, 29KEGG, 53Reactome
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Pathways related to H. Pylori Infection according to GeneCards/GeneDecks:

(show all 24)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.4IL17F
2
Cell adhesion ECM remodeling
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10.3MMP3, MMP7
310.2IL12B, IL12A, IL1B
4
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10.2IL12B, IL12A, IL1B
510.2IL12B, IL12A, IL1B
610.2IL1B, IL12A, IL12B
710.2IL1B, CXCL1, IFNGR1
810.2IL1B, IL12B, CXCL1
9
Cytokine production by Th17 cells in CF (Mouse model)
10.2CXCL1, IL12B, IL17F
10
Immune response Bacterial infections in normal airways
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10.2IFNGR1, DEFB4A, IL1RN, IL1B
11
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10.1IFNGR1, IL12B, IL12A, IL1B
12
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10.1IL1B, IL12A, IL12B, IFNGR1
1310.1IL1B, IL12A, IL12B, IFNGR1
1410.1CXCL1, CXCR1, CXCR2
1510.1IL12B, IL12A, IL1B, F2RL1
16
Development PDGF signaling via STATs and NF-kB
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10.1IL1B, IL17F, IL12B, CXCL1
17
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10.1PTPRZ1, IL12A, IL12B, CXCL1
1810.1CXCL1, IL12B, IL12A, IL1B
19
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10.1CXCR2, CXCR1, CXCL1, PTPRZ1
20
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10.0HSPA2, IFNGR1, IL12B, IL12A, IL1B
21
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10.0IL1B, IL12A, IL12B, IFNGR1, HSPA2
22
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10.0IFNGR1, CXCR2, CXCR1, CXCL1, IL12A
2310.0IL1B, IL12A, IL12B, CXCL1, HSPA2
24
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9.9HSPA2, IFNGR1, IL12B, IL12A, IL17F, IL1B

Compounds for genes affiliated with H. Pylori Infection

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44Novoseek, 49PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to H. Pylori Infection according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8DEFB4A
2hbd24410.5DEFB103B, DEFB4A, IL1B
3grogamma4410.5CXCR2, CXCR1, CXCL1
4amoxicillin44 49 1112.5S100A8, GAST, IL1RN
5[125i]cxcl8 (human)2810.5CXCR1, CXCR2
6peptidoglycan44 2811.5DEFB4A, IL1B, IL1RN, IL12B
7flagellin44 2811.5S100A8, DEFB4A, IL1B
8cxcl12810.5CXCR2, CXCR1
9grobeta4410.5CXCR2, CXCR1, CXCL1
10prostaglandin4410.5IL1RN, MMP7, MMP3, IL1B
11cxcl82810.5CXCR1, CXCR2
12fmlp4410.5CXCL1, F2RL1, IL1RN, CXCR2
13infliximab44 49 1112.5MMP3, IL1B, IL1RN, CXCL1
145 aminosalicylic acid4410.5CXCL1, IL1B, IL12B
15groalpha4410.5CXCL1, CXCR1, IL1B, CXCR2
16cxcl62810.5CXCR1, CXCR2
17clarithromycin44 1111.5S100A8, IL1RN, GAST
18lipoteichoic acid4410.4IL1B, IL1RN, IL12B, CXCR2, DEFB4A
19sulfasalazine44 28 49 1113.4IL12B, MMP3, IL1B, CXCL1, IL1RN
20dexamethasone44 49 28 1113.4CXCL1, CXCR1, DEFB4A, DEFB103B, S100A8
21endotoxin4410.4CXCR2, DEFB4A, CXCL1, S100A8, F2RL1
22oxygen44 2411.4S100A8, IFNGR1, CXCR1, CXCR2, F2RL1
23leflunomide49 44 1112.3MMP3, IL1B, IL1RN
24ribonucleic acid4410.3IL1RN, IL1B, MMP7, MMP3, CXCL1
25leukotriene b444 59 2412.3IL1B, CXCR2, CXCR1, F2RL1, CXCL1, IL1RN
26methotrexate44 49 1112.3MMP3, IL1B, IL1RN, CXCL1, S100A8
27alginate4410.3IL1RN, MMP3, IL1B
28pd 98,0594410.3F2RL1, CXCL1, DEFB4A, MMP3, IL12B, IL1B
29p0024410.3IL1RN, MMP3, MMP7, DEFB4A
30heparin44 28 11 2413.3F2RL1, CXCR2, MMP3, CXCL1, DEFB4A, IL1RN
31genistein44 28 59 2 11 2415.2IL1B, F2RL1, DEFB4A, CXCR2, CXCR1, MMP3
32rantes4410.2DEFB4A, S100A8, CXCR1, CXCL1, IL12B, IL1B
33etanercept44 49 1112.2IL1RN, MMP3, IL1B
34paraffin4410.2MMP3, MMP7, DEFB4A, CDX2, MUC6, S100A8
35superoxide44 2411.2S100A8, CXCR1, CXCL1, CXCR2, F2RL1, IL1B
36vitamin d4410.2CDX2, IL12B, IL1RN, MMP3, GAST
37sb 20358044 5911.1DEFB4A, CXCL1, IL12B, IL1RN, IL1B, MMP3
38progesterone44 59 28 11 2414.1MUC6, DEFB4A, CDX2, CXCL1, MMP7, MMP3
39histamine44 28 2412.1F2RL1, CXCL1, S100A8, GAST, DEFB4A, IL1RN
40oligonucleotide4410.1S100A8, CDX2, F2RL1, MMP7, CXCL1, CXCR1
41nitric oxide44 11 2412.1S100A8, MMP7, CXCL1, IL12B, IL1RN, IL1B
42vegf4410.0GAST, IL1B, MMP3, CXCR1, MMP7, CXCL1
43retinoic acid44 2411.0MMP7, CXCR1, IL1B, IL1RN, CXCL1, DEFB4A
44lipid449.9IL1RN, F2RL1, IL12B, MMP3, CXCR1, CXCR2
45il 10449.9IL1B, IL1RN, IL12B
46phosphatidylinositol449.9CXCR1, IL12B, IL1RN, MMP7, CXCR2, F2RL1
47cysteine449.8CXCR1, CXCL1, IL1RN, MMP7, F2RL1, CXCR2
48serine449.7F2RL1, MMP3, IL1RN, CXCL1, CXCR2, S100A8
49tyrosine449.7MMP7, CXCL1, MMP3, CDX2, CXCR1, IL1RN
50calcium44 49 11 2412.5CXCR2, S100A8, GAST, DEFB103B, DEFB4A, CDX2

GO Terms for genes affiliated with H. Pylori Infection

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16Gene Ontology
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Cellular components related to H. Pylori Infection according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-12 complexGO:04351410.3IL12A, IL12B
2extracellular spaceGO:0056159.5MMP7, S100A8, CXCL1, IL12B, IL12A, IL1RN
3extracellular regionGO:0055769.3S100A8, GAST, DEFB4A, MUC6, CXCL1, IL17F

Biological processes related to H. Pylori Infection according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1interleukin-8-mediated signaling pathwayGO:03811210.6CXCR2, CXCR1
2positive regulation of tyrosine phosphorylation of Stat4 proteinGO:04252010.6IL12A, IL12B
3positive regulation of NK T cell activationGO:05113510.5IL12A, IL12B
4positive regulation of interferon-gamma productionGO:03272910.5IL1B, IL12A, IL12B
5positive regulation of lymphocyte proliferationGO:05067110.5IL12B, IL12A
6positive regulation of granulocyte macrophage colony-stimulating factor productionGO:03272510.5IL12B, IL1B
7positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetGO:00286010.5IL12B, IL12A
8positive regulation of T cell proliferationGO:04210210.5IL12B, IL12A, IL1B
9neutrophil chemotaxisGO:03059310.5S100A8, CXCR2, IL1B
10positive regulation of natural killer cell activationGO:03281610.4IL12A, IL12B
11positive regulation of smooth muscle cell apoptotic processGO:03439310.4IL12A, IL12B
12chemotaxisGO:00693510.4CXCL1, CXCR1, CXCR2, DEFB4A
13negative regulation of interleukin-17 productionGO:03270010.4IL12B, IL12A
14immune responseGO:00695510.3DEFB4A, CXCL1, IL12A, IL1RN, IL1B
15response to UV-BGO:01022410.3IL12A, IL12B
16G-protein coupled receptor signaling pathwayGO:00718610.3GAST, DEFB4A, CXCR1, CXCL1, F2RL1
17dendritic cell chemotaxisGO:00240710.3CXCR1, CXCR2
18neutrophil activationGO:04211910.2F2RL1, CXCR2
19inflammatory responseGO:00695410.1F2RL1, IL1B, IL17F, CXCL1, CXCR1, CXCR2
20regulation of I-kappaB kinase/NF-kappaB cascadeGO:04312210.0F2RL1, IL1B

Molecular functions related to H. Pylori Infection according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1interleukin-1 receptor bindingGO:00514910.3IL1B, IL1RN
2interleukin-8 receptor activityGO:00491810.3CXCR1, CXCR2
3interleukin-8 bindingGO:01995910.3CXCR1, CXCR2
4cytokine activityGO:00512510.0IL12B, IL12A, IL17F, IL1B
5interleukin-12 receptor bindingGO:00514310.0IL12A, IL12B

Products for genes affiliated with H. Pylori Infection

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  • Antibodies
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Sources for H. Pylori Infection

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet