Haemophilus Influenzae malady

Wikipedia: Haemophilus influenzae, formerly called Pfeiffer\'s bacillus or Bacillus influenzae, is a Gram-negative,...⁴⁴ more...

MalaCards: Haemophilus Influenzae, also known as hemophilus influenzae, is related to epiglottitis and avian influenza. An important gene associated with Haemophilus Influenzae is PKD1 (polycystic kidney disease 1 (autosomal dominant)), and among its related pathways are Bacterial infections in CF airways and Immune response_Bacterial infections in normal airways. The compounds endotoxin and sb 203580 have been mentioned in the context of this disorder. Affiliated tissues include lung, colon and tonsil, and related mouse phenotypes are respiratory system and endocrine/exocrine gland.

haemophilus influenzae 30 hemophilus influenzae 30

h. influenzae 30 influenza 43

Diseases related to haemophilus influenzae by text searches and GeneDecks gene sharing:

(show top 50)    (show all 697)

id	Related Disease	Score	Top Affiliating Genes
1	epiglottitis	33.2	LACTB, ATP8A2, TIRAP, OMP
2	avian influenza	32.6	IL6, MAPK14, TNF, PTGS2
3	bronchitis	31.6	LACTB, MPO, IL8, LTF
4	hepatitis b	29.3	IL10, IL2RA, ALB, CAT, TLR2
5	immunodeficiency	28.3	IL10, IL2RA, IL6, HLA-B, TNF, LTF
6	otitis media	27.9	MUC2, MUC5AC, LACTB, MPO, MED1, IL10
7	tonsillitis	27.6	LACTB, IL10, IL1A, IL2RA, ICAM1, CAT
8	chronic obstructive pulmonary disease	27.5	MUC2, MUC5AC, LACTB, MPO, IL6, IL8
9	respiratory failure	27.4	MUC2, MUC5AC, LACTB, CAT, PTGS1
10	arthritis	26.8	IL1A, IL1B, IL6, IL8, TNF
11	tuberculosis	25.9	IL10, IL1B, TNF, TLR4, TIRAP
12	meningitis	25.7	PIK3CG, VDAC1, CMAS, BAMBI, LBP, LACTB
13	hepatitis c	25.4	IL10, CCL4, TXN, TNF, LTF, TLR2
14	mumps	25.3	IL1B, IL2RA, IL6, ICAM1, TNF
15	stomatitis	25.1	PIK3CG, IL10, IL1A, IL1B, IL6, CAT
16	conjunctivitis	25.1	LACTB, MPO, IL1A, IL8, MAPK1, ICAM1
17	hepatitis a	24.5	IL10, IL1B, IL2RA, ALB, CAT, HLA-B
18	gastroenteritis	24.4	VDAC1, LACTB, IL10, IL1B, IL6, IL8
19	febrile seizures	24.4	IL10, IL1A, IL1B, IL6, IL8, CCL4
20	rubella	23.8	IL10, IL1B, IL2RA, IL6, CAT, HLA-B
21	sepsis	23.7	VTN, VDAC1, LBP, LACTB, MPO, IL10
22	influenza	23.6	PIK3CG, VTN, NAPSA, VDAC1, CMAS, CLEC7A
23	acquired immunodeficiency syndrome	23.6	IL10, IL1B, IL2RA, IL6, ICAM1, ALB
24	bronchial asthma	23.4	MUC5AC, MPO, IL10, IL1A, IL1B, IL2RA
25	nasopharyngitis	23.2	PIK3CG, MUC5AC, LACTB, MPO, MED1, IL10
26	cork-handlers' disease	22.9	MPO, FN1, IL1A, IL6, IL8, ALB
27	aspergillosis	22.8	CLEC7A, IL10, IL1A, IL1B, IL2RA, IL6
28	sinusitis	22.5	MUC2, MUC5AC, LACTB, MPO, IL1B, IL2RA
29	seizures	22.5	IL10, IL1A, IL1B, IL6, IL8, CCL4
30	encephalomyelitis	22.2	CFH, MPO, IL10, IL1B, IL6, CCL4
31	vaccinia	22.0	PIK3CG, IL10, IL1A, MAPK14, MAPK1, CCL4
32	pneumonia	21.7	VTN, VDAC1, MUC5AC, LBP, LACTB, CFH
33	copd	21.1	MUC5AC, BAMBI, LBP, LACTB, MPO, IL10
34	cystic fibrosis	21.0	PIK3CG, VDAC1, MUC2, MUC5AC, LBP, LACTB
35	herpes simplex	20.3	PIK3CG, IL10, IL1B, IL2RA, IL6, IL8
36	pertussis	20.2	PIK3CG, VDAC1, LBP, CFH, ATP8A2, IL10
37	b-cell lymphomas	20.1	PIK3CG, MUC2, MPO, FN1, IL10, IL1A
38	schizophrenia	20.1	PIK3CG, FN1, IL10, IL1A, IL1B, IL2RA
39	acute lymphoblastic leukemia	20.0	PIK3CG, VDAC1, MPO, IL10, IL1B, IL2RA
40	lymphoblastic leukemia	20.0	PIK3CG, VDAC1, MPO, IL10, IL1B, IL2RA
41	measles	19.8	PIK3CG, IL10, IL1A, IL1B, IL2RA, IL6
42	fibrosis	19.4	PIK3CG, VTN, VDAC1, MUC2, MUC5AC, LBP
43	bronchiolitis	19.4	MUC2, MUC5AC, MPO, IL10, IL1A, IL1B
44	blindness	19.3	PIK3CG, LACTB, CFH, MPO, IL10, IL1A
45	peritonitis	19.2	VTN, MUC2, MUC5AC, LBP, LACTB, MPO
46	noma	19.1	PIK3CG, MPO, IL10, IL1A, IL1B, IL2RA
47	pulmonary disease	19.0	PIK3CG, MUC2, MUC5AC, LBP, LACTB, CFH
48	asthma	18.2	PIK3CG, VTN, MUC2, MUC5AC, LBP, MPO
49	atherosclerosis	16.7	PIK3CG, VTN, LBP, CFH, MPO, FN1
50	cervicitis	16.0	PIK3CG, VTN, VDAC1, MUC2, MUC5AC, MPO

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to haemophilus influenzae:

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MGI Mouse Phenotypes related to haemophilus influenzae:

²⁵ (show all 20)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.5	MED1, CLEC7A, GLRX, PKD1, CYLD
2	endocrine/exocrine gland phenotype	MP:0005379	10.0	TLR3, MED1, CYLD, CSN3, TLR2, CSN2
3	hematopoietic system phenotype	MP:0005397	9.5	TIRAP, TFRC, SOD2, TLR9, TLR7, NT5E
4	digestive/alimentary phenotype	MP:0005381	9.1	MUC2, EGFR, C4B, PKD1, PLG, PLAT
5	renal/urinary system phenotype	MP:0005367	9.0	NT5E, PTGS1, TRAF6, SOD2, PRDX6, TLR7
6	integument phenotype	MP:0010771	8.9	PTGS1, TRAF6, FECH, MED1, BAMBI, PIK3CG
7	other phenotype	MP:0005395	8.9	FN1, PTGS2, PTGS1, PKD1, TLR2, CXCR3
8	liver/biliary system phenotype	MP:0005370	8.7	MED1, PLG, PTN, DUSP1, LBP, TRAF6
9	nervous system phenotype	MP:0003631	8.3	VDAC1, MED1, MAPK1, DUSP1, PTN, PLG
10	skeleton phenotype	MP:0005390	7.6	NFKB1, PIK3CG, BAMBI, FN1, IL6, MAPK14
11	immune system phenotype	MP:0005387	7.1	IL6, HPX, TNF, DUSP1, PTN, PTGS1
12	growth/size phenotype	MP:0005378	6.4	PKD1, EGFR, PLG, NFKB1, OMP, TFRC
13	vision/eye phenotype	MP:0005391	6.3	HTRA1, SOD2, TNF, TRAF6, GLRX, ICAM1
14	reproductive system phenotype	MP:0005389	6.1	TRAF6, MAPK1, IL6, IL10, MED1, FN1
15	mortality/aging	MP:0010768	5.6	TLR7, VDAC1, CLEC7A, MAPK1, IL6, CFH
16	tumorigenesis	MP:0002006	5.5	IL1A, IL10, FN1, MUC2, PLG, TLR2
17	muscle phenotype	MP:0005369	4.6	MAPK1, PIK3CG, PKD1, MPO, FN1, IL6
18	homeostasis/metabolism phenotype	MP:0005376	3.5	TRAF6, DUSP1, PTGS2, PTN, PTGS1, TBP
19	cellular phenotype	MP:0005384	3.3	IL6, IL2RA, IL10, MED1, FN1, PIK3CG
20	cardiovascular system phenotype	MP:0005385	3.1	TBP, SOD2, ROM1, PLAT, PTGS1, PTGS2

Articles related to haemophilus influenzae:

(show top 50)    (show all 158)

id	Title	Authors	Year	Affiliating Genes
1	Characterization of nontypeable Haemophilus influenza e collected from respiratory infections and invasive disease cases in Manitoba, Canada. (20041949)	Shuel M.... Tsang R.S.	2010	LACTB
2	The TGF-beta-pseudoreceptor BAMBI is strongly express ed in COPD lungs and regulated by nontypeable Haemophilus influenzae. (20513241)	DrAPmann D.... Goldmann T.	2010	BAMBI
3	Antimicrobial resistance in Haemophilus influenzae re spiratory tract isolates in Korea: results of a nationwide acute respiratory in fections surveillance. (19884366)	Bae S.... Kang Y.	2010	LACTB
4	Nontypeable Haemophilus influenzae clearance by alveo lar macrophages is impaired by exposure to cigarette smoke. (19620348)	MartA--Lliteras P.... Garmendia J.	2009	PIK3CG
5	Peritonitis in the course of peritoneal dialisis cau sed by Haemophilus influenzae with BLNAR phenotype (19580200)	Miklaszewska M.... Hryniewicz W.	2009	LACTB
6	Glucocorticoids inhibit nontypeable Haemophilus influenzae-induced MUC5AC mucin expression via MAPK phosphatase-1-dependent inhibition of p38 MAPK. (18957283)	Komatsu K.... Li J.D.	2008	MUC5AC
7	Probability of achieving requisite pharmacodynamic exposure for oral beta-lactam regimens against Haemophilus influenzae in children. (18998749)	Pichichero M.E.... Nicolau D.P.	2008	LACTB
8	In vitro resistance rates of Streptococcus pneumonia e and Haemophilus influenzae clinical isolates to the antibiotics used in thera py (17933256)	Uncu H.... Arslan H.	2007	LACTB
9	lgtC expression modulates resistance to C4b deposition on an invasive nontypeable Haemophilus influenzae. (17202363)	Ho D.K.... Smith A.L.	2007	C4B
10	Resistance of Haemophilus influenzae isolates in children under 5 years old with acute respiratory infections in China between 2000 and 2002. (17697534)	Shen X.Z.... Yang Y.H.	2007	LACTB
11	Hydrogen peroxide scavenging is not a virulence deter minant in the pathogenesis of Haemophilus influenzae type b strain Eagan. (16430767)	Vergauwen B.... van Beeumen J.J.	2006	CAT
12	Live Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis activate the inflammatory response through Toll-like receptors 2, 4, and 9 in species-specific patterns. (16731773)	Mogensen T.H.... Ostergaard L.	2006	TLR2, TLR4, TLR9
13	Conserved nontypeable Haemophilus influenzae-derived TLR2-binding lipopeptides synergize with IFN-beta to increase cytokine production by resident murine and human alveolar macrophages. (16785566)	Punturieri A.... Curtis J.L.	2006	OMP
14	Characterization of genetic and phenotypic diversity of invasive nontypeable Haemophilus influenzae. (16113304)	Erwin A.L.... Smith A.L.	2005	ODC1, TDO2
15	Production of nontypeable Haemophilus influenzae HtrA by recombinant Bordetella pertussis with the use of filamentous hemagglutinin as a carrier. (15972522)	Alonso S.... Locht C.	2005	HTRA1
16	Haemophilus influenzae luxS mutants form a biofilm an d have increased virulence. (16099134)	Daines D.A.... Smith A.L.	2005	XS
17	Host risk factors for acquirement of antimicromial r esistant gene in Haemophilus influenzae (15977562)	Matsumoto A.... Suzuki H.	2005	LACTB
18	Quinolone-resistant Haemophilus influenzae in a long- term care facility: clinical and molecular epidemiology. (15156444)	Nazir J.... Rahal J.J.	2004	LACTB
19	Serotypes of Haemophilus influenzae strains isolated from pediatric patients with respiratory tract infections. (15109122)	Luong D.C.... Kohno Y.	2004	LACTB
20	Surveillance of Haemophilus influenzae serotypes and antimicrobial resistance in Colombia, 1994-2002 (12872558)	Ovalle M.V.... Uzeta M.	2003	LACTB
21	Outer-membrane-protein subtypes of Haemophilus influenzae isolates from North India. (12867564)	Kaur R.... Chakraborti A.	2003	OMP
22	Antimicrobial susceptibility of 840 clinical isolates of Haemophilus influenzae collected in four European countries in 2000-2001. (12848759)	Blosser-Middleton R.... Karlowsky J.A.	2003	LACTB
23	Transforming growth factor-beta -Smad signaling pathway cooperates with NF-kappa B to mediate nontypeable Haemophilus influenzae-induced MUC2 mucin transcription. (12237307)	Jono H.... Li J.D.	2002	MUC2
24	Apparent plateau in beta-lactamase production among clinical isolates of Haemophilus influenzae and Moraxella catarrhalis in the United States: results from the LIBRA Surveillance initiative. (11850164)	Jones M.E.... Sahm D.F.	2002	LACTB
25	Interaction of vitronectin with Haemophilus influenza e. (12423774)	Eberhard T.... Ullberg M.	2002	VTN
26	Susceptibility of nontypeable Haemophilus influenzae to human beta-defensins is influenced by lipooligosaccharide acylation. (12183584)	Starner T.D.... McCray P.B.	2002	DEFB4A
27	Drug resistant Haemophilus influenzae from respirator y tract infection in a tertiary care hospital in north India. (11370501)	Nag V.L.... Prasad K.N.	2001	LACTB
28	beta-Lactamase activities and resistance to antibiotics of Haemophilus influenzae, H. parainfluenzae and H. aphrophilus strains identified in throat cultures from children. (11116755)	Uraz G.... Celik B.	2000	LACTB
29	Haemophilus influenzae stimulates ICAM-1 expression on respiratory epithelial cells. (10754314)	Frick A.G.... Look D.C.	2000	IL8
30	In vitro susceptibilities to 23 antimicrobial agents of Haemophilus influenzae from pediatric patients in Japan. (11059221)	Matsuo Y.	2000	LACTB
31	Study on serotyping of Haemophilus influenzae and the positive rates of beta-lactamase (11776776)	Wang G.... Xiu Q.	1999	LACTB
32	Haemophilus influenzae and Moraxella catarrhalis from patients with community-acquired respiratory tract infections: antimicrobial s usceptibility patterns from the SENTRY antimicrobial Surveillance Program (Unit ed States and Canada, 1997). (9925540)	Doern G.V.... Kugler K.	1999	LACTB
33	Increasing prevalence of ampicillin- resistant, non-beta-lactamase-producing strains of Haemophilus influenzae in children in Japan. (9876205)	Seki H.... Koizumi S.	1999	LACTB
34	Acute epiglottitis caused by Haemophilus influenzae type b in children: presentation of 21 cases (9527370)	del Carmen Otero M.... Santos M.	1997	LACTB
35	Conservation and antigenic cross-reactivity of the tr ansferrin-binding proteins of Haemophilus influenzae, Actinobacillus pleuropneu moniae and Neisseria meningitidis. (9004513)	Holland J.... Williams P.	1996	TF
36	Ferrochelatase activity and protoporphyrin IX utilization in Haemophilus influenzae. (7768877)	Loeb M.R.	1995	FECH
37	Susceptibility of clinically significant Haemophilus influenzae strains to oral antimicrobial agents used in Saudi Arabia. (7842823)	Shibl A.M.... Gaillot O.	1994	LACTB
38	In vitro effect of dexamethasone, pentoxifylline, and anti-endotoxin monoclonal antibody on the release of proinflammatory mediators by human leukocytes stimulated with Haemophilus influenzae type B. (7936825)	van Furth A.M.... van Furth R.	1994	IL1B, IL8
39	Efficacy of passive immunotherapy in experimental pos tsplenectomy sepsis due to Haemophilus influenzae type B. (8301456)	Camel J.E.... Mahour G.H.	1993	ALB
40	Antibodies to Haemophilus influenzae type b outer mem brane proteins in children with epiglottitis or meningitis and in healthy contr ols. (8454359)	Johnson P.D.... Gilbert G.L.	1993	OMP
41	Expression of the Haemophilus influenzae transferrin receptor is repressible by hemin but not elemental iron alone. (8406790)	Morton D.J.... Stull T.L.	1993	TF, TFRC
42	Environmental chemoprevention of Haemophilus influenzae type B meningitis. Consequences of 2 indirectly related case pairs (1640949)	Hoppe J.E.... Niethammer D.	1992	ROM1
43	Evidence for in vivo expression of transferrin-bindin g proteins in Haemophilus influenzae type b. (1612763)	Holland J.... Williams P.	1992	TFRC
44	Epitope analysis of an immunodominant domain on the P 1 protein of Haemophilus influenzae type b using synthetic peptides and anti-id iotypic antibodies. (1522798)	Proulx C.... Brodeur B.R.	1992	OMP
45	Multiply resistant Haemophilus influenzae type b caus ing meningitis. (1398808)	Amarnath S.K.... Srinivasan S.	1992	LACTB
46	Differences in subtype distribution of Haemophilus influenzae type b from carriers in the general population and patients with meningitis. (2056515)	van Alphen L.... Geelen-van den Broek L.	1991	OMP
47	Haemophilus influenzae type B: subtyping of strains isolated from respiratory infections using the outer membrane protein profiles (2102010)	Catalano M.... Ochoa L.B.	1990	OMP
48	Peritonsillar abscess in a child caused by ampicilli n resistant Haemophilus influenzae (2124011)	Madsen L.P.	1990	LACTB
49	Cefuroxime treatment failure of nontypable Haemophilus influenzae meningitis associated with alteration of penicillin-binding proteins. (2230238)	Mendelman P.M.... Rubin L.G.	1990	PKD1
50	Anti-adhesive activity of human casein against Strept ococcus pneumoniae and Haemophilus influenzae. (2215182)	Aniansson G.... Svanborg C.	1990	CSN3, CSN1S1

Genes related to haemophilus influenzae according to GeneCards:

(show top 50)    (show all 82)

id	Symbol	Description	Score	GeneCards Section Context
1	PKD1	polycystic kidney disease 1 (autosomal dominant)	11.0	Publications
2	ATP8A2	ATPase, aminophospholipid transporter, class I, type 8A, member 2	11.0
3	IGKV1-6	immunoglobulin kappa variable 1-6	11.0	Publications
4	IGKV1-33	immunoglobulin kappa variable 1-33	11.0	Publications
5	IGKV1D-33	immunoglobulin kappa variable 1D-33	11.0	Publications
6	XS	X-linked suppressor of LU antigens	11.0	Publications
7	OMP	olfactory marker protein	11.0	Publications
8	IGHD	immunoglobulin heavy constant delta	11.0	Publications
9	LACTB	lactamase, beta	11.0	Publications
10	CMAS	cytidine monophosphate N-acetylneuraminic acid synthetase	11.0	Publications
11	NAPSA	napsin A aspartic peptidase	11.0	Publications
12	IGKV2D-29	immunoglobulin kappa variable 2D-29	11.0	Publications
13	HPX	hemopexin	11.0	Publications
14	ROM1	retinal outer segment membrane protein 1	11.0	Publications
15	GALE	UDP-galactose-4-epimerase	11.0	Publications
16	DUSP5	dual specificity phosphatase 5	11.0	Publications
17	CLEC7A	C-type lectin domain family 7, member A	11.0	Publications
18	BAMBI	BMP and activin membrane-bound inhibitor homolog (Xenopus laevis)	11.0	Publications
19	CSN3	casein kappa	11.0	Publications
20	SAMM50	sorting and assembly machinery component 50 homolog (S. cerevisiae)	11.0	Orthologs
21	TIRAP	toll-interleukin 1 receptor (TIR) domain containing adaptor protein	11.0	Publications
22	TDO2	tryptophan 2,3-dioxygenase	11.0	Publications
23	GLRX	glutaredoxin (thioltransferase)	11.0	Publications
24	MR1	major histocompatibility complex, class I-related	11.0	Publications
25	CSN2	casein beta	11.0	Publications
26	CFHR1	complement factor H-related 1	11.0	Publications
27	CYLD	cylindromatosis (turban tumor syndrome)	11.0	Publications
28	C4BPB	complement component 4 binding protein, beta	11.0	Publications
29	DHRS2	dehydrogenase/reductase (SDR family) member 2	11.0	Publications
30	NT5E	5'-nucleotidase, ecto (CD73)	11.0	Publications
31	C4B	complement component 4B (Chido blood group)	11.0	Publications
32	DEFB4A	defensin, beta 4A	11.0	Publications
33	HTRA1	HtrA serine peptidase 1	11.0	Publications
34	PRDX6	peroxiredoxin 6	11.0	Publications
35	LBP	lipopolysaccharide binding protein	11.0	Publications
36	MED1	mediator complex subunit 1	11.0	Publications
37	MUC2	mucin 2, oligomeric mucus/gel-forming	11.0	Publications
38	DUSP1	dual specificity phosphatase 1	11.0	Publications
39	FECH	ferrochelatase	11.0	Publications
40	TLR7	toll-like receptor 7	11.0	Publications
41	VDAC1	voltage-dependent anion channel 1	11.0	Publications
42	VTN	vitronectin	11.0	Publications
43	CXCR3	chemokine (C-X-C motif) receptor 3	11.0	Publications
44	TRAF6	TNF receptor-associated factor 6, E3 ubiquitin protein ligase	11.0	Publications
45	MUC5AC	mucin 5AC, oligomeric mucus/gel-forming	11.0	Publications
46	ODC1	ornithine decarboxylase 1	11.0	Publications
47	LTF	lactotransferrin	11.0	Publications
48	TBP	TATA box binding protein	11.0	Publications
49	TLR3	toll-like receptor 3	11.0	Publications
50	PTN	pleiotrophin	11.0	Publications

Pathways related to haemophilus influenzae according to GeneDecks:

(show top 50)    (show all 115)

id	Pathway	Score	Top Affiliating Genes
1	Bacterial infections in CF airways41	10.6	DEFB4A, TIRAP, TLR2, LBP
2	Immune response_Bacterial infections in normal airways41	10.1	IL1B, TRAF6, TIRAP, DEFB4A, LBP
3	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response10	10.0	TIRAP, IL6, LBP, TRAF6, TLR7
4	Toll-Like Receptors Pathway36	9.5	TLR2, TLR9, LBP, MAPK14, TRAF6, NFKB1
5	Inflammasome Activation Pathways37	9.2	NFKB1, TIRAP, TLR9, TLR7, IL1B, TLR4
6	TLR-TRIF Pathway36	9.1	TLR4, TIRAP, MAPK14, MAPK1, TRAF6, NFKB1
7	Th1 Differentiation37	9.1	TLR4, TLR9, TLR7, TLR3, TLR2, TNF
8	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.0	TLR2, TLR7, TLR4, TLR3, IL6, IL1B
9	Cytokine production by Th17 cells in CF41	9.0	LBP, ICAM1, TRAF6, NFKB1, TLR4, IL6
10	Amoebiasis20	8.9	TLR2, IL8, IL1B, FN1, TLR4, MUC2
11	Immune response_TLR signaling pathways41	8.8	FN1, TIRAP, LBP, IL8, TRAF6, NFKB1
12	TRAF Pathway36	8.6	NFKB1, TLR2, TIRAP, TLR9, TLR7, TLR4
13	Toll-Like Receptor Signaling Pathways37	8.6	TIRAP, IL6, IL1B, NFKB1, TLR2, TLR3
14	Th17 Differentiation37	8.5	TLR9, TLR7, TLR4, TLR3, TLR2, IL6
15	TREM1 Pathway36	8.2	TLR4, TLR3, MAPK14, TLR7, TLR9, TLR2
16	NF-kappaB Signaling3	8.2	CYLD, PTGS1, PTGS2, TNF, TRAF6, TXN
17	Measles20	8.2	PIK3CG, IL1A, IL1B, TLR7, TLR2, IL2RA
18	Mucin expression in CF via TLRs, EGFR signaling pathways41	8.1	TRAF6, TIRAP, MUC5AC, IL6, MAPK14, MAPK1
19	IL-10 Pathway36	8.0	IL10, NFKB1, MAPK14, IL6, IL1B, IL1A
20	HMGB1 Pathway36	8.0	IL1B, TLR4, NFKB1, TNF, MAPK1, IL1A
21	Malaria20	8.0	TNF, TLR9, TLR4, TLR2, IL10, IL1B
22	14-3-3 Induced Apoptosis36	8.0	TLR4, NFKB1, IL1A, IL1B, MAPK14, MAPK1
23	Immune response MIF in innate immunity response10	7.8	TNF, IL6, IL8, MAPK14, TLR4, NFKB1
24	Immune response_MIF in innate immunity response41	7.8	LBP, TLR4, NFKB1, TNF, TRAF6, MAPK14
25	Immune response IL-1 signaling pathway10	7.8	NFKB1, PTGS2, TNF, TRAF6, MAPK14, IL8
26	Immune response_IL-1 signaling pathway41	7.8	TNF, NFKB1, PTGS2, MAPK14, IL8, IL6
27	Endothelin-1 Signaling Pathway36	7.7	EGFR, IL1A, IL10, IL1B, IL6, MAPK1
28	Immune response MIF-mediated glucocorticoid regulation10	7.7	IL8, MAPK1, TNF, PTGS2, NFKB1, IL6
29	NF-KappaB (p50-p65) Pathway36	7.7	TLR7, IL6, TLR9, IL1B, TNF, PTN
30	Immune response_MIF-mediated glucocorticoid regulation41	7.7	MAPK1, TNF, ICAM1, PTGS2, NFKB1, IL8
31	NF-KappaB Family Pathway36	7.7	NFKB1, TLR3, IL1A, TLR7, TLR9, TLR4
32	NOD-like receptor signaling pathway20	7.6	NFKB1, IL8, MAPK1, MAPK14, IL6, TRAF6
33	Osteoclast differentiation20	7.6	IL1A, IL1B, MAPK14, CYLD, NFKB1, PIK3CG
34	Toxoplasmosis20	7.6	NFKB1, TLR4, TLR2, PIK3CG, TRAF6, MAPK1
35	Colorectal Cancer Metastasis36	7.2	TLR2, IL6, MAPK1, TNF, TLR3, EGFR
36	Leishmaniasis20	7.1	TNF, PTGS2, TLR4, IL1A, IL10, IL1B
37	Glucocorticoid Receptor Signaling36	6.9	IL1B, NFKB1, IL10, IL1A, IL2RA, IL6
38	Tuberculosis20	6.8	NFKB1, TNF, TRAF6, MAPK1, TLR4, TLR9
39	PEDF Induced Signaling36	6.7	IL10, IL1A, IL1B, IL6, IL8, MAPK1
40	Pertussis20	6.7	TIRAP, TLR4, C4BPB, C4B, NFKB1, TNF
41	STAT3 Pathway36	6.7	IL6, IL1B, IL1A, IL2RA, IL8, CXCR3
42	Influenza A20	6.6	PIK3CG, TLR7, VDAC1, IL1A, IL1B, IL6
43	p38 Signaling36	6.6	NFKB1, EGFR, IL8, CXCR3, IL10, PTN
44	Toll-like receptor signaling pathway20	6.6	TLR9, TIRAP, TLR7, TLR4, TLR3, PIK3CG
45	Tec Kinases Signaling36	6.5	IL2RA, IL6, IL1B, IL1A, TLR3, CXCR3
46	Chagas disease (American trypanosomiasis)20	6.5	PIK3CG, IL10, IL1B, IL8, MAPK14, MAPK1
47	MIF Mediated Glucocorticoid Regulation36	6.5	IL6, IL8, MAPK1, CCL4, TNF, PTGS2
48	MIF Regulation of Innate Immune Cells36	6.5	IL10, IL6, TLR4, NFKB1, PTGS2, TNF
49	Antioxidant Action of Vitamin-C36	6.1	GLRX, IL1B, IL2RA, IL6, IL8, MAPK1
50	MAPK Family Pathway36	6.1	TNF, PTN, NFKB1, EGFR, IL6, IL1A

Compounds related to haemophilus influenzae according to GeneDecks:

(show top 50)    (show all 328)

id	Compound	Score	Top Affiliating Genes
1	endotoxin32	9.9	LBP, CXCR3, DEFB4A, TLR9, TLR3, LTF
2	sb 20358032 42	10.5	TNF, CCL4, MAPK14, IL6
3	n acetylcysteine32	9.5	TLR4, EGFR, LTF, PLG, ODC1, DUSP1
4	egcg32	9.5	PIK3CG, IL1A, MAPK14, CSN2, CSN1S1, ODC1
5	flagellin32	9.2	CXCR3, IL1B, IL8, TLR3, TLR4, TLR9
6	ascorbic acid32 18	10.0	ODC1, TXN, HPX, GLRX, IL2RA, IL1A
7	pge232	8.8	FN1, MUC5AC, VTN, CSN1S1, TF, TLR4
8	groalpha32	8.7	CXCR3, TNF, ICAM1, CCL4, MAPK14, IL1B
9	polyinosinic-polycytidylic acid32	8.4	TLR2, HLA-B, MAPK14, IL8, IL6, IL10
10	polysaccharide32	8.4	LTF, PTN, HLA-B, HPX, ICAM1, CCL4
11	estrogen32	8.4	GLRX, LTF, EGFR, TF, DEFB4A, CSN2
12	rantes32	8.3	IL1A, IL2RA, IL6, CXCR3, DEFB4A, TLR9
13	histamine32 18	9.3	CCL4, IL2RA, MPO, MUC5AC, ICAM1, ALB
14	h2o232	8.3	LTF, VDAC1, PIK3CG, MPO, IL2RA, ODC1
15	heparin32 9 18 9	11.2	CFH, LBP, VTN, PIK3CG, DEFB4A, C4BPB
16	peptidoglycan32	8.1	OMP, DEFB4A, TLR9, TLR7, TLR4, TLR3
17	cysteine32	8.0	CSN1S1, PRDX6, TFRC, LTF, PLAT, ODC1
18	poly(i-c)32	7.9	TNF, TLR9, TLR3, TLR4, TLR7, TRAF6
19	iron32 18	8.7	TLR4, LTF, TBP, PTGS1, PTGS2, HLA-B
20	polymyxin b32	7.7	IL8, IL6, IL1B, IL1A, IL10, LBP
21	oxygen32 18	8.6	MAPK14, MPO, LBP, MUC5AC, VDAC1, MAPK1
22	il 1032	7.6	TLR2, TNF, CCL4, IL8, IL6, IL2RA
23	ccl332	7.5	CXCR3, TLR9, TLR4, TLR2, TNF, ICAM1
24	lipoteichoic acid32	7.5	TNF, HLA-B, MAPK14, IL8, IL6, IL1B
25	pentoxifylline32 9 9	9.4	LTF, ICAM1, NT5E, TNF, IL8, IL6
26	fibrinogen32	7.4	CSN3, CSN1S1, TF, TLR4, TLR2, LTF
27	superoxide32 18	8.3	FECH, SOD2, IL8, MAPK14, CXCR3, PRDX6
28	diphenyleneiodonium32	7.2	MPO, IL8, MAPK14, MAPK1, ICAM1, CAT
29	alanine32	7.0	ALB, HTRA1, CCL4, IL6, FECH, MED1
30	vitamin d32	6.9	HPX, CSN1S1, TLR2, TXN, ALB, IL1A
31	triptolide32	6.9	PTGS1, PTGS2, DUSP1, TNF, ICAM1, CCL4
32	lactate32	6.7	CSN2, CSN1S1, ICAM1, IL8, IL6, FN1
33	phosphatidylinositol32	6.7	NT5E, DUSP1, MAPK1, CXCR3, TFRC, TLR4
34	indomethacin32 9 9	8.1	SOD2, TFRC, LTF, PLAT, PTGS1, PTGS2
35	15-deoxy-delta-12,14-prostaglandin j232	6.1	PTGS1, PIK3CG, PTGS2, MAPK14, IL10, TNF
36	nitric oxide32 9 18 9	9.1	TLR3, TLR2, NFKB1, PLG, ODC1, PTGS1
37	pdtc32	6.1	CAT, SOD2, TLR4, PTGS2, TNF, ICAM1
38	vegf32	6.0	PIK3CG, VTN, MPO, FN1, IL1A, IL1B
39	cyclosporin a32 42	6.9	TXN, HLA-B, ICAM1, CCL4, IL8, IL6
40	pd 98,05932	5.6	CSN2, CXCR3, DEFB4A, TLR2, EGFR, PTGS2
41	curcumin32	5.5	IL8, IL6, IL1B, IL1A, VTN, PIK3CG
42	herbimycin a32 42	6.5	IL2RA, IL1B, IL1A, FN1, VTN, PIK3CG
43	ly29400232	5.0	MUC2, TLR4, CXCR3, SOD2, CSN1S1, TLR3
44	genistein32 9 18 9	7.8	SOD2, IL6, IL2RA, IL1B, IL1A, FN1
45	actinomycin d32	4.7	SOD2, TFRC, MAPK1, MAPK14, IL8, IL6
46	tyrosine32	4.6	CSN2, CSN1S1, SOD2, CXCR3, PRDX6, DEFB4A
47	retinoic acid32 42 18	6.1	PTN, FN1, MPO, CFH, MUC5AC, MUC2
48	serine32	3.9	GLRX, MUC5AC, MUC2, VDAC1, VTN, PIK3CG
49	dexamethasone32 42 34 9 9	7.6	PTGS1, IL2RA, IL1B, IL1A, IL10, FN1
50	cycloheximide32	3.6	SOD2, TFRC, TLR4, TLR2, MAPK14, IL8

Cellular components related to haemophilus influenzae according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	endolysosome membrane	GO:036020	10.1	TLR7, TLR3, TLR9
2	secretory granule	GO:030141	9.3	PLAT, IL1B, TF, MPO, LTF
3	endosome membrane	GO:010008	9.1	TLR9, TLR7, TLR4, TRAF6, EGFR, TF
4	extracellular region	GO:005576	6.3	IL8, CSN1S1, CSN3, CSN2, IGKV1D-33, CCL4
5	extracellular space	GO:005615	5.4	EGFR, IL1B, IL1A, IL10, FN1, CFHR1

Biological processes related to haemophilus influenzae according to GeneDecks:

(show top 50)    (show all 61)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of interferon-alpha biosynthetic process	GO:045356	10.5	TLR9, TLR3, TLR7
2	cellular response to lipoteichoic acid	GO:071223	10.4	TLR2, TIRAP, TLR4, LBP
3	pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response	GO:052033	10.4	TLR3, TLR7, TLR4
4	positive regulation of toll-like receptor signaling pathway	GO:034123	10.4	TLR9, TLR3, TLR2
5	positive regulation of interferon-beta biosynthetic process	GO:045359	10.4	TLR4, TLR7, TLR3, TLR9
6	microglial cell activation involved in immune response	GO:002282	10.3	TLR4, TLR3, TLR7
7	I-kappaB phosphorylation	GO:007252	10.3	TLR2, TLR3, TLR9, TLR7, TLR4
8	positive regulation of interleukin-12 production	GO:032735	10.3	TLR9, TLR3, TIRAP, TLR4, TLR2
9	positive regulation of tumor necrosis factor production	GO:032760	10.2	TLR4, TLR2, LBP, TLR9, TIRAP, CLEC7A
10	positive regulation of inflammatory response	GO:050729	10.2	TLR2, TLR9, TLR3, TLR7, TLR4
11	positive regulation of interferon-beta production	GO:032728	10.2	TLR2, TLR3, TLR9, TLR4
12	positive regulation of interleukin-8 biosynthetic process	GO:045416	9.9	TLR7, TLR4, TNF
13	positive regulation of interleukin-6 biosynthetic process	GO:045410	9.8	TIRAP, TRAF6, IL1B
14	negative regulation of growth of symbiont in host	GO:044130	9.7	LBP, TLR2, IL10, TNF, TIRAP
15	positive regulation of interleukin-8 production	GO:032757	9.7	TLR2, LBP, IL1B, TLR3, TLR7, TLR9
16	negative regulation of interleukin-6 production	GO:032715	9.6	TLR9, TLR4, TNF, IL10
17	defense response to Gram-positive bacterium	GO:050830	9.6	TIRAP, TLR2, IL6, LBP, TNF
18	defense response to bacterium	GO:042742	9.6	TLR9, TLR4, TLR3, LTF, DEFB4A, IL10
19	cellular response to mechanical stimulus	GO:071260	9.6	TLR7, TLR4, TLR3, NFKB1, IL1B
20	lipopolysaccharide-mediated signaling pathway	GO:031663	9.5	IL1B, LBP, MAPK14, TNF, TLR2, TLR4
21	positive regulation of NF-kappaB import into nucleus	GO:042346	9.5	TNF, IL1B, TLR2, TLR3, TLR4, TLR7
22	positive regulation of JNK cascade	GO:046330	9.4	TLR4, TIRAP, TLR9, TNF, IL1B, IL1A
23	cellular response to lipopolysaccharide	GO:071222	9.3	TLR4, ICAM1, IL8, LBP, IL10
24	response to oxidative stress	GO:006979	9.3	MPO, PRDX6, TLR4, NFKB1, PTGS1, PTGS2
25	positive regulation of cytokine secretion	GO:050715	9.3	IL10, TNF, IL1A, TLR2
26	immune response	GO:006955	9.3	TLR2, TLR4, IL1A, IL2RA, MR1, VTN
27	cellular component movement	GO:006928	9.3	PTGS2, MAPK14, CXCR3, TXN, IL8, CCL4
28	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	9.3	IL1A, TIRAP, TLR9, TLR4, TLR3, TNF
29	positive regulation of chemokine production	GO:032722	9.2	TLR4, TNF, LBP, IL6, TLR2, TLR3
30	TRIF-dependent toll-like receptor signaling pathway	GO:035666	9.1	MAPK14, MAPK1, TRAF6, TLR4, TLR3, NFKB1
31	toll-like receptor 3 signaling pathway	GO:034138	9.1	NFKB1, TRAF6, TLR3, MAPK1, MAPK14, TLR4
32	positive regulation of fever generation	GO:031622	9.1	TNF, PTGS2, IL1B
33	toll-like receptor 1 signaling pathway	GO:034130	9.1	MAPK14, MAPK1, TRAF6, NFKB1, TLR2, TIRAP
34	toll-like receptor 2 signaling pathway	GO:034134	9.1	NFKB1, MAPK1, TLR2, TIRAP, TRAF6, MAPK14
35	toll-like receptor signaling pathway	GO:002224	9.1	TLR4, TRAF6, NFKB1, TIRAP, MAPK1, MAPK14
36	MyD88-dependent toll-like receptor signaling pathway	GO:002755	9.1	MAPK14, TIRAP, TLR4, TRAF6, TLR2, MAPK1
37	toll-like receptor 4 signaling pathway	GO:034142	9.0	TLR4, TRAF6, MAPK14, NFKB1, MAPK1, TLR2
38	Toll signaling pathway	GO:008063	9.0	TLR4, TLR3, LBP, MAPK14, MAPK1, TRAF6
39	MyD88-independent toll-like receptor signaling pathway	GO:002756	8.7	MAPK14, TLR3, TRAF6, MAPK1, NFKB1
40	positive regulation of nitric oxide biosynthetic process	GO:045429	8.6	PTGS2, EGFR, TLR2, IL1B, ICAM1, TLR4
41	activation of MAPK activity	GO:000187	8.6	MAPK1, IL1B, MAPK14, TLR4, TRAF6, TNF
42	positive regulation of interleukin-6 production	GO:032755	8.6	LBP, IL1A, IL1B, IL6, TNF, TLR2
43	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.1	TLR2, IL1B, IL6, ICAM1, CAT, TRAF6
44	negative regulation of apoptotic process	GO:043066	8.1	PIK3CG, SOD2, MED1, IL6, ALB, CAT
45	response to glucocorticoid stimulus	GO:051384	8.0	PLAT, TNF, DUSP1, PTGS2, IL1B, IL6
46	platelet activation	GO:030168	8.0	PIK3CG, FN1, MAPK14, MAPK1, IL6, PLG
47	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.0	MAPK14, IL1B, IL1A, MED1, IL6, TRAF6
48	negative regulation of cell proliferation	GO:008285	7.8	ATP8A2, IL1A, IL6, IL8, TNF, PTGS2
49	innate immune response	GO:045087	7.8	TLR9, PIK3CG, CLEC7A, LBP, CFH, MAPK14
50	inflammatory response	GO:006954	6.6	TIRAP, IL10, CLEC7A, PIK3CG, IL1A, IL1B

Molecular functions related to haemophilus influenzae according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	interleukin-1 receptor binding	GO:005149	9.7	IL1A, IL1B, TLR9
2	heme binding	GO:020037	8.9	MPO, FECH, CAT, PTGS2, PTGS1, TDO2