MCID: HRN019
MIFTS: 26

Hair-an Syndrome malady

Summaries for Hair-an Syndrome

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42NIH Rare Diseases, 32MalaCards
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NIH Rare Diseases:42 Hair-an syndrome is a condition that affects women. it is characterized by hyperandrogenism, insulin resistance, and acanthosis nigricans. insulin resistance is a condition in which the body produces insulin but does not use it properly. this causes the pancreas to produce more insulin. high levels of insulin stimulate the ovaries to make too much androgen, leading too excessive  hair growth, acne, and irregular periods. insulin resistance can also lead to diabetes, high blood pressure, heart disease, and excessive growth and darkening of the skin (aconthosis nigricans). women with hair-an may be born with insulin resistance or acquire it over time. last updated: 5/27/2011

MalaCards: Hair-an Syndrome, also known as hyperandrogenism , insulin resistance , and acanthosis nigricans, is related to polycystic ovary syndrome and acanthosis nigricans. An important gene associated with Hair-an Syndrome is INSR (insulin receptor), and among its related pathways are AMPK Enzyme Complex Pathway and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. The compounds palmitate and poly(glu(80)tyr(20)) have been mentioned in the context of this disorder. Affiliated tissues include heart, pancreas and skin.

Aliases & Classifications for Hair-an Syndrome

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42NIH Rare Diseases, 60UMLS
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Aliases & Descriptions:

hair-an syndrome 42 60
hyperandrogenism , insulin resistance , and acanthosis nigricans 42
hyperandrogenic, insulin-resistant acanthosis nigricans syndrome 42


Related Diseases for Hair-an Syndrome

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17GeneCards, 18GeneDecks
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Diseases in the Hair Disease family:

hair-an syndrome

Diseases related to Hair-an Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1polycystic ovary syndrome30.7INSR, INS
2acanthosis nigricans30.2INSR, INS
3hyperandrogenism30.1INS, INSR
4obesity10.5
5ovarian stromal hyperthecosis10.5
6fetal macrosomia10.0INS
7hyperinsulinemic hypoglycemia10.0INS
8amenorrhea10.0INS
9growth hormone deficiency10.0INS
10acromegaly10.0INS
11maturity-onset diabetes of the young10.0INS
12hypogonadism10.0INS
13fatty liver disease10.0INS
14hypothyroidism10.0INS
15werner syndrome10.0INSR
16uremia10.0INSR
17myotonic dystrophy10.0INSR
18hepatoblastoma10.0INSR
19liver cirrhosis10.0INSR
20rabson-mendenhall syndrome10.0INSR, INS
21donohue syndrome10.0INS, INSR
22congenital generalized lipodystrophy type 210.0INSR, INS
23gestational diabetes10.0INSR, INS
24glucose intolerance10.0INS, INSR
25hyperinsulinism10.0INSR, INS
26retinal disease10.0INS, INSR
27lipodystrophy10.0INSR, INS
28type 1 diabetes10.0INS, INSR
29hypertriglyceridemia10.0INSR, INS
30metabolic syndrome x10.0INSR, INS
31hyperthyroidism10.0INSR, INS
32hypoglycemia10.0INS, INSR
33coronary artery disease10.0INSR, INS
34insulinoma10.0INSR, INS
35hypercholesterolemia10.0INSR, INS
36type 2 diabetes mellitus10.0INSR, INS
37diabetic retinopathy10.0INSR, INS
38primary hyperoxaluria10.0INSR, INS
39cholera10.0INSR, INS
40hyperglycemia10.0INS, INSR
41essential hypertension10.0INSR, INS
42vitiligo10.0
43diabetes mellitus10.0
44hypertension10.0
45mood disorder10.0

Graphical network of the top 20 diseases related to Hair-an Syndrome:



Diseases related to hair-an syndrome

Clinical Features for Hair-an Syndrome

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Drugs & Therapeutics for Hair-an Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hair-an Syndrome

Drug clinical trials:

Search ClinicalTrials for Hair-an Syndrome

Search NIH Clinical Center for Hair-an Syndrome

Search CenterWatch for Hair-an Syndrome

Genetic Tests for Hair-an Syndrome

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Anatomical Context for Hair-an Syndrome

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32MalaCards
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MalaCards organs/tissues related to Hair-an Syndrome:

32
Heart, Pancreas, Skin, Ovary

Animal Models for Hair-an Syndrome or affiliated genes

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Publications for Hair-an Syndrome

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Genetic Variations for Hair-an Syndrome

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Expression for genes affiliated with Hair-an Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hair-an Syndrome

Search GEO for disease gene expression data for Hair-an Syndrome.

Pathways for genes affiliated with Hair-an Syndrome

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Sources:
51QIAGEN, 52R&D Systems, 53Reactome, 29KEGG, 4Cell Signaling Technology, 12EMD Millipore, 37NCBI BioSystems Database, 49PharmGKB
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Pathways related to Hair-an Syndrome according to GeneCards/GeneDecks:

(show all 25)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.1INSR, INS
2
Hide members
9.1INS, INSR
39.1INSR, INS
4
Hide members
9.1INS, INSR
59.1INSR, INS
69.1INSR, INS
7
Translation Insulin regulation of translation
Hide members
9.1INSR, INS
8
Hide members
9.1INSR, INS
9
Hide members
9.1INSR, INS
109.1INSR, INS
11
Hide members
9.1INS, INSR
129.1INSR, INS
13
Hide members
9.1INS, INSR
149.1INSR, INS
15
Hide members
9.1INS, INSR
169.1INS, INSR
179.1INSR, INS
18
Transcription Transcription factor Tubby signaling pathways
Hide members
9.1INSR, INS
199.1INS, INSR
209.1INSR, INS
219.1INSR, INS
229.1INSR, INS
23
Hide members
9.1INS, INSR
249.1INSR, INS
25
Hide members
9.1INSR, INS

Compounds for genes affiliated with Hair-an Syndrome

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB
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Compounds related to Hair-an Syndrome according to GeneCards/GeneDecks:

(show all 32)
idCompoundScoreTop Affiliating Genes
1palmitate4410.2INS
2poly(glu(80)tyr(20))449.5INSR, INS
3chromium picolinate449.5INSR, INS
4mecasermin44 1110.5INSR, INS
5vanadyl sulfate449.5INS, INSR
6preproinsulin449.5INSR, INS
7moxonidine449.5INSR, INS
8glimepiride44 49 1111.5INSR, INS
9gliclazide44 49 1111.5INS, INSR
10clomiphene citrate449.5INSR, INS
11aicar44 11 2411.5INSR, INS
12alpha lipoic acid449.5INSR, INS
13streptozotocin449.5INS, INSR
14fenofibrate44 49 1111.5INSR, INS
15glibenclamide44 28 49 5912.5INSR, INS
162-deoxyglucose44 1110.5INSR, INS
17octreotide44 59 28 1112.4INS, INSR
18metformin44 49 1111.4INSR, INS
19c-peptide449.4INSR, INS
20pioglitazone44 49 28 1112.4INSR, INS
21hydrocortisone44 2 59 1112.4INS, INSR
22rosiglitazone44 49 28 11 2413.4INSR, INS
23troglitazone44 28 59 1112.4INSR, INS
24ibmx44 28 5911.3INSR, INS
25carbohydrates449.3INS, INSR
26thyroxine44 2410.3INSR, INS
27glycerol44 11 2411.2INSR, INS
28epinephrine44 11 2411.2INSR, INS
29rapamycin449.1INS, INSR
30glycogen44 2410.1INSR, INS
31ly294002449.0INSR, INS
32wortmannin448.8INSR, INS

GO Terms for genes affiliated with Hair-an Syndrome

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16Gene Ontology
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Biological processes related to Hair-an Syndrome according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of respiratory burstGO:0602679.4INSR, INS
2positive regulation of glycolysisGO:0458219.4INSR, INS
3positive regulation of glycogen biosynthetic processGO:0457259.4INSR, INS
4activation of protein kinase B activityGO:0321489.4INS, INSR
5positive regulation of mitosisGO:0458409.4INSR, INS
6positive regulation of glucose importGO:0463269.4INSR, INS
7positive regulation of nitric oxide biosynthetic processGO:0454299.3INSR, INS
8positive regulation of DNA replicationGO:0457409.3INS, INSR
9positive regulation of MAPK cascadeGO:0434109.3INSR, INS
10positive regulation of protein kinase B signaling cascadeGO:0518979.2INSR, INS
11glucose homeostasisGO:0425939.2INSR, INS
12positive regulation of cell migrationGO:0303359.1INS, INSR
13positive regulation of cell proliferationGO:0082849.1INSR, INS
14insulin receptor signaling pathwayGO:0082869.0INSR, INS
15G-protein coupled receptor signaling pathwayGO:0071868.8INSR, INS

Molecular functions related to Hair-an Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1insulin-like growth factor receptor bindingGO:0051599.1INSR, INS

Products for genes affiliated with Hair-an Syndrome

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  • Antibodies
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Sources for Hair-an Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet