MCID: HRD018
MIFTS: 41

Hair Disease malady

Skin diseases category

Summaries for Hair Disease

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Sources:
8Disease Ontology, 33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 The average person has 5 million hairs. hair grows all over your body except on your lips, palms, and the soles of your feet. it takes about a month for healthy hair to grow half an inch. most hairs grow for up to six years and then fall out. new hairs grow in their place. hair helps keep you warm. it also protects your eyes, ears and nose from small particles in the air. common problem with the hair and scalp include hair loss, infections, and flaking.

MalaCards: Hair Disease, also known as hair disorder, is related to menkes disease and monilethrix. An important gene associated with Hair Disease is KRT86 (keratin 86). The compounds sodium azide and carnitine have been mentioned in the context of this disorder. Affiliated tissues include hair, eye and skin.

Disease Ontology:8 An integumentary system disease that is located in hair.

Wikipedia:63 Hair diseases are disorders primarily associated with the follicles of the hair. more...

Aliases & Classifications for Hair Disease

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Sources:
8Disease Ontology, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases


Aliases & Descriptions:

hair disease 8
hair disorder 44
hair problems 33
hair diseases 60


External Ids:

Disease Ontology8 DOID:421
MeSH34 D006201
NCIt39 C34656
ICD1025 L67.9

Related Diseases for Hair Disease

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Hair Disease:



Diseases related to hair disease

Clinical Features for Hair Disease

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Drugs & Therapeutics for Hair Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Hair Disease

Drug clinical trials:

Search ClinicalTrials for Hair Disease

Search NIH Clinical Center for Hair Disease

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Genetic Tests for Hair Disease

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Anatomical Context for Hair Disease

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Hair Disease:

32
Eye, Skin, Cortex, Brain, Liver, Kidney, Placenta, Endothelial, T cells, Testis, Heart, Cerebellum, Whole blood, Spinal cord, Thalamus

FMA organs/tissues related to Hair Disease:

14
Hair

Animal Models for Hair Disease or affiliated genes

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Publications for Hair Disease

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Sources:
50PubMed
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Articles related to Hair Disease:

(show top 50)    (show all 138)
idTitleAuthorsYear
1
Recent advances in the pathogenesis of autoimmune hair loss disease alopecia areata. (24151515)
2013
2
Development of autoimmune hair loss disease alopecia areata is associated with cardiac dysfunction in C3H/HeJ mice. (23658656)
2013
3
Darkening of white hair following levodopa therapy in a patient with Parkinson's disease. (24166898)
2013
4
Monitoring the disease activity in pemphigus by direct immunofluorescence of plucked hair: a pilot study. (23716856)
2013
5
Kinky hair, kinky vessels, and bladder diverticula in Menkes disease. (20412396)
2011
6
A case report of motor neuron disease in a patient showing significant level of DDTs, HCHs and organophosphate metabolites in hair as well as levels of hexane and toluene in blood. (21851830)
2011
7
Fox-Fordyce disease following axillary laser hair removal. (21576577)
2011
8
Auditory and vestibular hair cell stereocilia: relationship between functionality and inner ear disease. (21774850)
2011
9
Menkes kinky hair disease: A case report. (18801184)
2008
10
Naxos disease: a rare occurrence of cardiomyopathy with woolly hair and palmoplantar keratoderma. (18187826)
2008
11
Neonatal onset of Menkes disease: diagnosis interest of cupremia and microscopic examination of the hairs]. (17651950)
2007
12
Hirschsprung disease associated with severe cartilage-hair hypoplasia. (11391344)
2001
13
Menkes kinky hair disease: an unusual case. (10872109)
2000
14
Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease). (10902626)
2000
15
Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix. (9241275)
1997
16
Menkes' kinky hair disease associated with a large bladder diverticulum: a case report. (9255676)
1997
17
Rapid hair regrowth in refractory alopecia universalis associated with autoimmune disease following liver transplantation and tacrolimus (FK506) therapy. (7539169)
1995
18
PCR analysis of hair root specimens to detect Tay-Sachs disease carriers in Ashkenazi Jews. (7874790)
1995
19
Histochemical study of mitochondrial enzymes in cerebellar cortex of macular mutant mouse, a model of Menkes kinky hair disease. (8009964)
1994
20
Cartilage-hair-hypoplasia and Hodgkin disease. (1442902)
1992
21
MR of progressive neurodegenerative change in treated Menkes' kinky hair disease. (2046911)
1991
22
Metallothionein messenger RNA levels in the macular mutant mouse: an animal model of Menkes' kinky-hair disease. (1912099)
1991
23
Urate oxidase activity and copper content in the liver of macular mutant mouse, a model animal for human congenital copper deficiency, Menkes' kinky hair disease. (1819648)
1991
24
Correction of cerebrospinal fluid copper in Menkes kinky hair disease. (1930426)
1991
25
A comparative immunocytochemical study of human cerebellar cortex in X-chromosome-linked copper malabsorption (Menkes' kinky hair disease) and granule cell type cerebellar degeneration. (2511498)
1989
26
Biochemical study on the brain of the macular mutant mouse as a model of Menkes' kinky hair disease. (2453126)
1988
27
Copper metabolism in the macular mutant mouse: an animal model of Menkes's kinky-hair disease. (3219371)
1988
28
Atypical Menkes steely hair disease. (3189407)
1988
29
Neuronal and vascular disorders of the brain and spinal cord in Menkes kinky hair disease. (3130871)
1987
30
Cerebral lipid and protein abnormalities in Menkes' steely-hair disease. (3599492)
1986
31
Thalamic lesions in a patient with Menkes kinky-hair disease. (4064386)
1985
32
Menkes' kinky hair disease: clinical and experimental study. (4042823)
1985
33
Copper-binding proteins in the liver and kidney from the patients with Menkes' kinky hair disease. (6836561)
1983
34
Menkes kinky hair disease: a search for closely linked restriction fragment length polymorphism. (6576980)
1983
35
Histochemical studies of fibroblasts from patients with Menkes kinky hair disease and Wilson's disease. (6290431)
1982
36
Menkes' kinky hair disease. (7187623)
1982
37
Inducibility of metallothionein biosynthesis in cultured normal and Menkes kinky hair disease fibroblasts: effects of copper and cadmium. (471576)
1979
38
Distribution of ingested and injected radiocopper in two patients with Menkes' kinky hair disease. (514694)
1979
39
Metal-binding studies of metallothioneins in Menkes kinky hair disease. (699318)
1978
40
Menkes kinky-hair disease. A report on its pathology. (654875)
1978
41
An autopsy case of Menkes kinky hair disease. (716884)
1978
42
Fine structure of the cerebellar cortex in Menkes Kinky-hair disease. X-chromosome-linked copper malabsorption. (831687)
1977
43
Hair-roots in screening and diagnosis of Tay-Sachs disease. (64809)
1977
44
New screening method for Wilson's disease and Menkes' kinky-hair disease. (73055)
1977
45
Fine structural changes in the cerebellar cortex in kinky hair disease. (1028277)
1976
46
Menkes kinky hair disease. A defect in metallothionein metabolism? (4458824)
1974
47
Study of copper metabolism in kinky hair disease (Menkes' disease) and in hepatolenticular degeneration (Wilson's disease) utilizing 67Cu and radioactivity counting in the total body and various tissues. (4219083)
1974
48
Menkes' kinky hair disease: further definition of the defect in copper transport. (4120259)
1973
49
Multiple defects of the hair shaft in Netherton's disease. Association with ichthyosis linearis circumflexa. (5359904)
1969
50
Kinky hair disease. II. Biochemical studies. (5922551)
1966

Genetic Variations for Hair Disease

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Expression for genes affiliated with Hair Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hair Disease

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Pathways for genes affiliated with Hair Disease

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Compounds for genes affiliated with Hair Disease

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44Novoseek, 24HMDB
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Compounds related to Hair Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1sodium azide449.4CP, COX5A
2carnitine449.4CP, COX5A
3copper histidine448.9CP, ATP7A, COX5A
4copper44 249.9COX5A, ATP7A, CP
5superoxide44 249.5CP, ATP7A, COX5A
6glutamate448.1COX5A, CNP, KRT86, CP

GO Terms for genes affiliated with Hair Disease

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16Gene Ontology
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Cellular components related to Hair Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.6KRT81, KRT86

Biological processes related to Hair Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1copper ion transportGO:0068259.3CP, ATP7A

Molecular functions related to Hair Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1copper ion bindingGO:0055079.3CP, ATP7A

Products for genes affiliated with Hair Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hair Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet