Aliases & Classifications for Hair Disease

MalaCards integrated aliases for Hair Disease:

Name: Hair Disease 12 14
Hair Diseases 42 69
Abnormality of the Hair 29
Hair Disorder 52
Hair Problems 41

Classifications:



External Ids:

Disease Ontology 12 DOID:421
MeSH 42 D006201
NCIt 47 C34656
ICD10 33 L67.9
UMLS 69 C0018500

Summaries for Hair Disease

MedlinePlus : 41 the average person has 5 million hairs. hair grows all over your body except on your lips, palms, and the soles of your feet. it takes about a month for healthy hair to grow half an inch. most hairs grow for up to six years and then fall out. new hairs grow in their place. hair helps keep you warm. it also protects your eyes, ears and nose from small particles in the air. common problem with the hair and scalp include hair loss, infections, and flaking.

MalaCards based summary : Hair Disease, also known as hair diseases, is related to menkes disease and ringed hair, and has symptoms including exanthema and pruritus. An important gene associated with Hair Disease is KRT86 (Keratin 86), and among its related pathways/superpathways are Keratinization and Copper homeostasis. The drugs Dopamine and Methylphenidate have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and brain, and related phenotypes are cellular and growth/size/body region

Disease Ontology : 12 An integumentary system disease that is located in hair.

Wikipedia : 72 Hair diseases are disorders primarily associated with the follicles of the... more...

Related Diseases for Hair Disease

Diseases in the Hair Disease family:

Hair-an Syndrome

Diseases related to Hair Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
id Related Disease Score Top Affiliating Genes
1 menkes disease 11.4
2 ringed hair 10.8
3 monilethrix 10.8
4 xp11.3 deletion syndrome 10.8 LIPH LPAR6
5 third-degree atrioventricular block 10.7 DSG4 KRT74
6 vesicoureteral reflux 7 10.7 DSP KRT74
7 waardenburg syndrome, type 2b 10.7
8 waardenburg syndrome, type 2a 10.7
9 waardenburg syndrome, type 2c 10.7
10 waardenburg syndrome, type 2d 10.7
11 waardenburg syndrome, type 4a 10.7
12 waardenburg syndrome, type 2e, with or without neurologic involvement 10.7
13 skin fragility-woolly hair syndrome 10.6 DSP KRT74
14 woolly hair, autosomal dominant 10.6 KRT74 LIPH
15 autism x-linked 4 10.6 MBTPS2 SAT1
16 waardenburg syndrome, type 1 10.5
17 waardenburg syndrome, type 3 10.5
18 dowling-degos disease 4 10.5
19 dowling-degos disease 1 10.5
20 dowling-degos disease 2 10.5
21 waardenburg syndrome, type 4b 10.5
22 waardenburg syndrome, type 4c 10.5
23 ectodermal dysplasia 2, clouston type 10.5
24 eec syndrome 10.5
25 hypotrichosis 7 10.5
26 ichthyosis deafness mental retardation skeletal anomaly 10.5 DSG4 LIPH LPAR6
27 fallopian tube disease 10.4 CDH3 LIPH
28 hypertrichosis 10.4
29 hypotrichosis 10.4
30 trichomalacia 10.4
31 kidney cancer, childhood 10.4 MBTPS2 SAT1
32 loose anagen hair syndrome 10.4
33 x-linked complicated spastic paraplegia type 1 10.4 DSP KRT74 LIPH LPAR6
34 dysentery 10.3 MBTPS2 SAT1
35 communicating hydrocephalus 10.3 MBTPS2 SAT1
36 symmetric circumferential skin creases, congenital, 2 10.3 DSG4 KRT74 LIPH LPAR6
37 3mc syndrome 1 10.3 DSG4 KRT74 LIPH LPAR6
38 thiopurines, poor metabolism of, 2 10.3 DSG4 KRT74 LIPH LPAR6
39 spastic paraplegia 50, autosomal recessive 10.3 ATP7A ATP7B
40 ectodermal dysplasia 4, hair/nail type 10.2 DSG4 KRT74 KRT81 KRT86 LPAR6
41 inflammatory bowel disease 21 10.1 BACE1 HAUS3 TRPV1
42 chronic cholangitis 10.0 MBTPS2 SAT1
43 amelogenesis imperfecta 9.9 ANTXR1 DSP KRT81 KRT86 MBTPS2 VDR
44 basophil adenoma 9.8 CDH3 DSG4 KRT74 KRT86 LIPH LPAR6
45 cerebritis 9.6
46 neuronitis 9.6
47 cartilage-hair hypoplasia 9.6
48 argininosuccinic aciduria 9.4
49 ataxia-telangiectasia 9.4
50 hepatitis 9.4

Graphical network of the top 20 diseases related to Hair Disease:



Diseases related to Hair Disease

Symptoms & Phenotypes for Hair Disease

UMLS symptoms related to Hair Disease:


exanthema, pruritus

MGI Mouse Phenotypes related to Hair Disease:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.06 ANTXR1 ATP7A ATP7B BACE1 CNP DSP
2 growth/size/body region MP:0005378 10 ATP7A ATP7B BACE1 CNP DSG4 DSP
3 integument MP:0010771 9.85 ATP7A ATP7B BACE1 CDH3 DSG4 DSP
4 muscle MP:0005369 9.5 ATP7A ATP7B BACE1 CNP DSP ERCC3
5 reproductive system MP:0005389 9.23 ANTXR1 ATP7A ATP7B CNP ERCC3 LPP

Drugs & Therapeutics for Hair Disease

Drugs for Hair Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 378)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
2
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
3
Minoxidil Approved Phase 4,Phase 3,Phase 1,Phase 2 38304-91-5 4201
4
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
6
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
7
Finasteride Approved Phase 4,Phase 3,Phase 1,Phase 2 98319-26-7 57363
8
Bimatoprost Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 155206-00-1 5311027
9
Ketoconazole Approved, Investigational Phase 4 65277-42-1 47576 3823
10
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2 22916-47-8 4189
11
Betamethasone Approved, Vet_approved Phase 4,Phase 2 378-44-9 9782
12
Latanoprost Approved, Investigational Phase 4 130209-82-4 5282380 5311221
13
Hydroxychloroquine Approved Phase 4 118-42-3 3652
14
Capsaicin Approved Phase 4 404-86-4 1548943
15
Imiquimod Approved, Investigational Phase 4 99011-02-6 57469
16
Cephalexin Approved, Vet_approved Phase 4 15686-71-2 27447
17
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
18
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
19
Prilocaine Approved Phase 4 721-50-6 4906
20
Tetracaine Approved, Vet_approved Phase 4 94-24-6 5411
21
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
22
Spironolactone Approved Phase 4,Phase 2 1952-01-7, 52-01-7 5833
23
Lovastatin Approved, Investigational Phase 4 75330-75-5 53232
24 Dolutegravir Approved Phase 4 1051375-16-6 54726191
25
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
26
Maraviroc Approved, Investigational Phase 4 376348-65-1 3002977
27
Ornithine Approved, Nutraceutical Phase 4,Phase 2 70-26-8, 3184-13-2 6262 389
28 Orange Approved, Nutraceutical Phase 4
29
Clobetasol Investigational Phase 4,Phase 3 25122-46-7, 25122-41-2 32798 5311051
30 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
31 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1
32 Emollients Phase 4
33 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
34 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
35 Hormones Phase 4,Phase 3,Phase 2,Phase 1
36 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
37 Central Nervous System Stimulants Phase 4
38 Dopamine Agents Phase 4
39 Dopamine Uptake Inhibitors Phase 4
40 Neurotransmitter Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
41 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 1
42 Antihypertensive Agents Phase 4,Phase 3,Phase 1,Phase 2
43 Vasodilator Agents Phase 4,Phase 3,Phase 1,Phase 2
44 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1
45 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1
46 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 1,Phase 2
47 Anti-Asthmatic Agents Phase 4,Phase 2,Phase 3,Phase 1
48 Respiratory System Agents Phase 4,Phase 2,Phase 3,Phase 1
49 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1
50 Adjuvants, Immunologic Phase 4,Phase 2

Interventional clinical trials:

(show top 50) (show all 440)

id Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Clobetasol Propionate 0.05% E Foam in Alopecia Unknown status NCT01111981 Phase 4 Clobetasol Propionate 0.05% Emollient Foam
2 Methylphenidate in ADHD With Trichotillomania Unknown status NCT00552266 Phase 4 Methylphenidate
3 NIMIP: Non Invasive Measurement of the Intracranial Pressure Unknown status NCT01685450 Phase 4
4 Pilot Study of a Novel IPL for Removal of Unwanted Fine Body Hair Completed NCT01912950 Phase 4
5 Minoxidil 1% for Eyebrow Enhancement Completed NCT01924000 Phase 4 Minoxidil lotion 1%;Placebo
6 Minoxidil 2% for Eyebrow Enhancement Completed NCT01672307 Phase 4 Minoxidil lotion 2%;Placebo
7 Safety and Efficacy of Bimatoprost 0.03% Solution for the Treatment of Thinning Eyebrows Completed NCT01891487 Phase 4 Track A;Track B
8 Study Assessing Patient Satisfaction With LATISSE® for Increasing Eyelash Prominence Completed NCT01448525 Phase 4 bimatoprost ophthalmic solution 0.03%;bimatoprost vehicle solution
9 Latisse (Bimatoprost .03% Opthalmic Solution) for the Treatment of Hypotrichosis of the Eyebrows: Latisse Versus Placebo Completed NCT01387906 Phase 4 topical bimatoprost
10 Safety and Efficacy of LATISSE® in the Augmentation of Eyelashes of Korean Subjects Completed NCT01229423 Phase 4 bimatoprost 0.03%
11 Study of Bimatoprost Solution in Increasing Eyelash Prominence in African Americans With Eyelash Hypotrichosis Completed NCT00958035 Phase 4 bimatoprost ophthalmic 0.03% solution;vehicle sterile solution (placebo)
12 Safety and Efficacy of Ketoconazole 2% Foam in the Treatment of Pityrosporum Folliculitis Completed NCT00824863 Phase 4 ketoconazole 2% foam
13 Safety and Efficacy of Bimatoprost Solution in Treating Eyelash Loss or Hypotrichosis in Children Completed NCT01023841 Phase 4 bimatoprost ophthalmic solution 0.03%;Vehicle Sterile Solution
14 Comparison of Topical Latanoprost vs Topical Corticosteroid in Treatment of Localized Alopecia Areata Completed NCT02350023 Phase 4 Topical latanoprost 0.005%;Topical betamethasone 0.05%
15 Plaquenil for Alopecia Areata, Alopecia Totalis Completed NCT00176982 Phase 4 Hydroxychloroquine
16 Response of Topical Capsaicin in Alopecia Areata Completed NCT00176969 Phase 4 Capsaicin
17 Treatment With Topical Eflornithin After Laser Treatment in Women With Facial Hirsutism Completed NCT01817894 Phase 4 Eflornithine cream 11.5 w/w %
18 Evaluation of Eflornithine on Facial and Forearm Skin Completed NCT00152048 Phase 4 Eflornithine hydrochloride
19 Aldara for the Treatment of Extensive Alopecia Areata Completed NCT00177021 Phase 4 Aldara Cream 5%
20 Safety and Efficacy of Oral Mega Pulse Methylprednisolone in Severe Therapy Resistant Alopecia Areata Completed NCT01167946 Phase 4 methylprednisolone sodium succinate;methylprednisolone sodium succinate;methylprednisolone sodium succinate
21 Characteristics of T Cells From Alopecia Areata Scalp Skin Before and After Treatment With Aldara 5% Completed NCT00176943 Phase 4 Aldara Cream 5%
22 Comparison of Cephalexin Versus Clindamycin for Suspected CA-MRSA Skin Infections Completed NCT00352612 Phase 4 clindamycin;cephalexin
23 The Efficacy of Laser Assisted Hair Removal in the Treatment of Acne Keloidalis Nuchae; a Pilot Study Completed NCT01548898 Phase 4
24 Study of Wound Packing After Superficial Skin Abscess Drainage Completed NCT00746109 Phase 4
25 7% Lidocaine/7% Tetracaine Cream Versus 2,5% Lidocaine / 2,5% Prilocaine Cream Completed NCT02372786 Phase 4 2,5% lidocaine / 2,5% prilocaine cream;7% lidocaine / 7% tetracaine cream
26 Twice Daily Altabax Application for the Treatment of Uncomplicated Soft Tissue Infection Completed NCT01126268 Phase 4 Retapamulin (Altabax)
27 Olanzapine in the Treatment of Hair Pulling (Trichotillomania) Completed NCT00182507 Phase 4 Olanzapine
28 Intralesional Steroids in the Treatment of Alopecia Areata Recruiting NCT01898806 Phase 4 Intralesional Triamcinolone 2.5 mg/ml;Intralesional Triamcinolone 5 mg/ml;Intralesional Triamcinolone 10 mg/ml;Intralesional Saline
29 Combining Lovastatin and a Parent-Implemented Language Intervention for Fragile X Syndrome Recruiting NCT02642653 Phase 4 Lovastatin
30 ENLIGHTEN: Establishing Novel Antiretroviral Imaging for Hair to Elucidate Non-Adherence Recruiting NCT03218592 Phase 4 Maraviroc Pill;Dolutegravir Pill;Truvada Pill
31 Comparing Different Platelet Rich Plasma (PRP) Treatment Regimens for Management of Androgenic Alopecia Active, not recruiting NCT02999737 Phase 4
32 Immunodeficiency in Cartilage-hair Hypoplasia: Sub-project on Safety of Vaccination Against Chickenpox Enrolling by invitation NCT02383797 Phase 4
33 The Use of 5mg Finasteride Versus 200mg Spironolactone and Topical 5% Minoxidil in Treating Postmenopausal Female Androgenetic Alopecia Withdrawn NCT02483195 Phase 4 5% Minoxidil;200mg Spironolactone;5mg Finasteride
34 Facial Hair Reduction Using Intense Pulsed Light (IPL) & Alexandrite Laser Unknown status NCT01461694 Phase 2, Phase 3
35 Efficacy and Safety of Mesotherapy With Minoxidil 0.5%/2ml for Androgenetic Alopecia in Female Patients Unknown status NCT01655108 Phase 3 Minoxidil;Saline
36 Prospective Study of Patients With Hirsutism Unknown status NCT00145288 Phase 2, Phase 3
37 Reflexology's Effect on Polycystic Ovary Syndrome: A Pilot Study Unknown status NCT00746148 Phase 3
38 Reflexology's Effect on Polycystic Ovary Syndrome (PCOS) Unknown status NCT00744510 Phase 3
39 Comparison of Efficacy, Safety and Tolerability of Two Different 810 nm Diode Lasers for Hair Reduction Completed NCT01212172 Phase 3
40 Bimatoprost for the Treatment of Eyebrow Hypotrichosis Completed NCT01765764 Phase 3 bimatoprost solution;Vehicle to bimatoprost solution
41 Bimatoprost in the Treatment of Eyelash Hypotrichosis Completed NCT01698554 Phase 3 bimatoprost formulation A solution;bimatoprost solution 0.03 %;vehicle of bimatoprost formulation A solution;vehicle of bimatoprost solution 0.03 %
42 Safety and Efficacy Study of Bimatoprost in Japanese Patients With Chemotherapy-Induced Eyelash Hypotrichosis Completed NCT01391286 Phase 3 bimatoprost solution 0.03%;bimatoprost vehicle solution
43 Safety and Efficacy Study of Bimatoprost in Japanese Patients With Eyelash Hypotrichosis Completed NCT01391273 Phase 3 bimatoprost solution 0.03%;bimatoprost vehicle solution
44 Study of Bimatoprost Gel on Eyelash Growth Completed NCT01200251 Phase 3 Bimatoprost eyelash gel
45 Safety and Efficacy Study of Bimatoprost to Treat Hypotrichosis of the Eyelashes After Application to the Eyelid Margin Completed NCT00907426 Phase 3 Bimatoprost 0.03% solution;Vehicle solution
46 The Randomized Double-blind Placebo-controlled Trial of Intralesional Botulinum Toxin A Injection for Recalcitrant Alopecia Totalis and Alopecia Universalis Completed NCT00997815 Phase 2, Phase 3 Botulinum toxin A;Normal saline injection
47 Enhancing Hair Density With Platelet Rich Fibrin Matrix (PRFM) Completed NCT01590238 Phase 3
48 Clinical Trial in Females With Female Pattern Hair Loss Completed NCT01145625 Phase 3 5% Minoxidil;2% Minoxidil
49 Clinical Trial in Females for Female Pattern Hair Loss Completed NCT01226459 Phase 3 5% Minoxidil Topical Foam;Vehicle Topical Foam
50 Efficacy and Safety Study to Compare Two Minoxidil Formulations on Women With Androgenetic Alopecia Completed NCT00958750 Phase 3 minoxidil

Search NIH Clinical Center for Hair Disease

Cochrane evidence based reviews: hair diseases

Genetic Tests for Hair Disease

Genetic tests related to Hair Disease:

id Genetic test Affiliating Genes
1 Abnormality of the Hair 29

Anatomical Context for Hair Disease

MalaCards organs/tissues related to Hair Disease:

39
Skin, Eye, Brain, Lung, Testes, Breast, Ovary

Publications for Hair Disease

Articles related to Hair Disease:

(show top 50) (show all 99)
id Title Authors Year
1
Menkes Kinky Hair Disease. ( 26840692 )
2016
2
Ataxia telangiectasia, menkes kinky hair disease, neurocutaneous melanosis: a review of these neurocutaneous syndromes and indications for clinical practice. ( 27002302 )
2016
3
Cerebellar expression of copper chaperone for superoxide, cytosolic cu/zn-superoxide dismutase, 4-hydroxy-2-nonenal, acrolein and heat shock protein 32 in patients with menkes kinky hair disease: immunohistochemical study. ( 25067875 )
2014
4
Menkes kinky hair disease. ( 23112368 )
2012
5
Hair care practices and scalp/hair disease in African American girls. ( 21571179 )
2011
6
Familial woolly hair disease. ( 20519796 )
2010
7
Trichothiodystrophy and fragile hair: the distinction between diagnostic signs and diagnostic labels in childhood hair disease. ( 19754869 )
2009
8
Menkes kinky hair disease: A case report. ( 18801184 )
2008
9
Menkes kinky hair disease (Menkes syndrome). A case report. ( 17053847 )
2006
10
Antiandrogen therapy for skin and hair disease. ( 16677962 )
2006
11
Psychological aspects of hair disease. ( 17166214 )
2005
12
Is kinky-hair disease a misnomer for Menkes syndrome? ( 11176670 )
2001
13
Menkes kinky hair disease: an unusual case. ( 10872109 )
2000
14
Hair today, gone tomorrow: transgenic mice with human repair deficient hair disease. ( 9657142 )
1998
15
Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix. ( 9241275 )
1997
16
Urologic abnormalities in Menkes' kinky hair disease: report of three cases. ( 9165480 )
1997
17
Menkes' kinky hair disease associated with a large bladder diverticulum: a case report. ( 9255676 )
1997
18
Kinky hair disease with multiple eruption cysts: a case report. ( 8936518 )
1996
19
Menkes' Kinky Hair disease: new considerations. ( 9141833 )
1996
20
Menkes' kinky-hair disease: radiologic findings in a patient treated with copper histidinate. ( 7704673 )
1995
21
Cerebellar superoxide dismutase expression in Menkes' kinky hair disease: an immunohistochemical investigation. ( 7484097 )
1995
22
Histochemical study of mitochondrial enzymes in cerebellar cortex of macular mutant mouse, a model of Menkes kinky hair disease. ( 8009964 )
1994
23
Copper distribution in fetus and placenta of the macular mutant mouse as a model of Menkes kinky hair disease. ( 7873696 )
1994
24
Menkes kinky hair disease. ( 8028455 )
1994
25
Cytochrome C oxidase deficiency and neuronal involvement in Menkes' kinky hair disease: immunohistochemical study. ( 8293191 )
1993
26
The decreased immune responses in macular mouse, a model of Menkes' kinky hair disease. ( 8434133 )
1993
27
Intracellular distribution of hepatic copper in macular mutant mice. An animal model of Menkes' kinky-hair disease. ( 7688531 )
1993
28
Effect of age and sex on copper-induced toxicity in the macular mutant mouse. An animal model for Menkes' kinky-hair disease. ( 7509170 )
1993
29
Menkes kinky hair disease: characteristic MR angiographic findings. ( 8237696 )
1993
30
MR of progressive neurodegenerative change in treated Menkes' kinky hair disease. ( 2046911 )
1991
31
Copper-induced toxicity in macular mutant mouse: an animal model for Menkes' kinky-hair disease. ( 1871775 )
1991
32
Metallothionein messenger RNA levels in the macular mutant mouse: an animal model of Menkes' kinky-hair disease. ( 1912099 )
1991
33
Urate oxidase activity and copper content in the liver of macular mutant mouse, a model animal for human congenital copper deficiency, Menkes' kinky hair disease. ( 1819648 )
1991
34
Correction of cerebrospinal fluid copper in Menkes kinky hair disease. ( 1930426 )
1991
35
Menkes' kinky hair disease: morphological and immunohistochemical comparison of two autopsied patients. ( 2028748 )
1991
36
[A pathophysiological study of macular mutant mouse as a model of human Menkes kinky hair disease. I. Copper contents and copper dependent enzyme activities in various organs]. ( 2175632 )
1990
37
Decreased blood flow and oxygen metabolism in the cerebellum, brain stem and thalamus in a case with Menkes kinky hair disease. ( 2618967 )
1989
38
A comparative immunocytochemical study of human cerebellar cortex in X-chromosome-linked copper malabsorption (Menkes' kinky hair disease) and granule cell type cerebellar degeneration. ( 2511498 )
1989
39
Cerebral MR of Menkes kinky-hair disease. ( 2492723 )
1989
40
Copper metabolism in the macular mutant mouse: an animal model of Menkes's kinky-hair disease. ( 3219371 )
1988
41
Biochemical study on the brain of the macular mutant mouse as a model of Menkes' kinky hair disease. ( 2453126 )
1988
42
Menkes kinky hair disease with 'ragged red' fibers. ( 3234609 )
1988
43
Kinky hair disease: twenty five years later. ( 2839049 )
1988
44
Catecholamine metabolism in kinky hair disease. ( 3233105 )
1988
45
Atypical Menkes steely hair disease. ( 3189407 )
1988
46
Golgi study on brain of macular mutant mouse as a model of Menkes kinky hair disease. ( 3577690 )
1987
47
Neuronal and vascular disorders of the brain and spinal cord in Menkes kinky hair disease. ( 3130871 )
1987
48
Metallothionein in kidney and liver of the macular mouse as an animal model of Menkes' kinky hair disease. ( 3449862 )
1987
49
Light and electron microscopic study on cerebellar cortex of macular mutant mouse as a model of Menkes kinky hair disease. ( 2821841 )
1987
50
Cerebral lipid and protein abnormalities in Menkes' steely-hair disease. ( 3599492 )
1986

Variations for Hair Disease

Expression for Hair Disease

Search GEO for disease gene expression data for Hair Disease.

Pathways for Hair Disease

Pathways related to Hair Disease according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.81 DSG4 DSP KRT74 KRT81 KRT86
2 11.06 ATP7A ATP7B BACE1
3 10.26 ATP7A ATP7B ERCC3

GO Terms for Hair Disease

Cellular components related to Hair Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 trans-Golgi network GO:0005802 9.43 ATP7A ATP7B BACE1
2 late endosome GO:0005770 9.33 ATP7A ATP7B BACE1
3 desmosome GO:0030057 9.32 DSG4 DSP
4 keratin filament GO:0045095 9.13 KRT74 KRT81 KRT86
5 intermediate filament GO:0005882 8.92 DSP KRT74 KRT81 KRT86

Biological processes related to Hair Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 single organismal cell-cell adhesion GO:0016337 9.63 CDH3 DSG4 DSP
2 intermediate filament cytoskeleton organization GO:0045104 9.48 DSP KRT74
3 response to copper ion GO:0046688 9.43 ATP7A ATP7B
4 lactation GO:0007595 9.43 ATP7A ATP7B VDR
5 copper ion transport GO:0006825 9.4 ATP7A ATP7B
6 cellular copper ion homeostasis GO:0006878 9.37 ATP7A ATP7B
7 cornification GO:0070268 9.35 DSG4 DSP KRT74 KRT81 KRT86
8 copper ion import GO:0015677 9.32 ATP7A ATP7B
9 copper ion export GO:0060003 9.16 ATP7A ATP7B
10 keratinization GO:0031424 9.1 CDH3 DSG4 DSP KRT74 KRT81 KRT86

Molecular functions related to Hair Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.56 DSP KRT74 KRT81 KRT86
2 cation-transporting ATPase activity GO:0019829 9.16 ATP7A ATP7B
3 copper ion transmembrane transporter activity GO:0005375 8.96 ATP7A ATP7B
4 copper-exporting ATPase activity GO:0004008 8.62 ATP7A ATP7B

Sources for Hair Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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