Hair Disease malady

Wikipedia: Hair diseases are disorders primarily associated with the follicles of the hair.⁴⁴ more...

MalaCards: Hair Disease, also known as hair disorder, is related to monilethrix and menkes disease. An important gene associated with Hair Disease is KRT86 (keratin 86). The compounds sodium azide and carnitine have been mentioned in the context of this disorder. Affiliated tissues include hair and cortex.

Disease Ontology: An integumentary system disease that is located in hair.⁶

Aliases & Descriptions:

hair disease 6 hair disorder 32

hair diseases 43

Diseases related to hair disease by text searches and GeneDecks gene sharing:

(show all 23)

id	Related Disease	Score	Top Affiliating Genes
1	monilethrix	28.5	KRT86, KRT81
2	menkes disease	28.3	CP, COX5A, ATP7A
3	pachyonychia congenita	12.9	KRT86, KRT81
4	epidermolytic hyperkeratosis	12.9	KRT81, KRT86
5	triple-a syndrome	12.9	KRT86, KRT81
6	epidermolysis bullosa simplex	12.9	KRT86, KRT81
7	congenital cataracts	12.5	CP, ATP7A
8	swayback	12.5	COX5A, CP
9	keratosis	12.4	CP, KRT81, KRT86
10	sideroblastic anemia	12.4	CP, COX5A
11	mitochondrial encephalomyopathy	12.3	COX5A, CP
12	wilson disease	12.3	ATP7A, CP
13	encephalomyopathy	12.3	COX5A, CP
14	ulceration of vulva	12.2	COX5A, CP
15	li-fraumeni syndrome	12.1	COX5A, CP
16	neurodegenerative disease	11.6	CP, COX5A, ATP7A
17	neurodegeneration	11.2	ATP7A, COX5A, CP
18	cerebritis	10.9	CP, COX5A, ATP7A, CNP
19	hair problems	5.2
20	neuronitis	5.2
21	pili annulati	5.2
22	trichomalacia	5.2
23	pseudofolliculitis barbae	5.1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to hair disease:

²²

FMA organs/tissues related to hair disease:

¹¹

Articles related to hair disease:

id	Title	Authors	Year	Affiliating Genes
1	Menkes kinky hair disease: A case report. (18801184)	Datta A.K.... Ghosh M.	2008	CP
2	Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix. (9241275)	Winter H.... Schweizer J.	1997	KRT86
3	Cytochrome C oxidase deficiency and neuronal involvement in Menkes' kinky hair disease: immunohistochemical study. (8293191)	Sparaco M.... Bonilla E.	1993	COX5A
4	A pathophysiological study of macular mutant mouse as a model of human Menkes kinky hair disease. I. Copper contents and copper dependent enzyme activities in various organs (2175632)	Tsurui S.... Sugie H.	1990	CNP

Genes related to hair disease according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	KRT86	keratin 86	11.0	Summaries, Publications
2	KRT81	keratin 81	11.0	Summaries
3	CNP	2',3'-cyclic nucleotide 3' phosphodiesterase	11.0	Publications
4	ATP7A	ATPase, Cu++ transporting, alpha polypeptide	11.0
5	COX5A	cytochrome c oxidase subunit Va	11.0	Publications
6	CP	ceruloplasmin (ferroxidase)	11.0	Publications

Compounds related to hair disease according to GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	sodium azide32	9.1	COX5A, CP
2	carnitine32	9.1	COX5A, CP
3	copper histidine32	8.6	ATP7A, COX5A, CP
4	copper32 18	9.6	CP, COX5A, ATP7A
5	superoxide32 18	9.2	ATP7A, COX5A, CP
6	glutamate32	8.1	CP, KRT86, COX5A, CNP

Cellular components related to hair disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	keratin filament	GO:045095	9.6	KRT86, KRT81

Biological processes related to hair disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	copper ion transport	GO:006825	9.3	ATP7A, CP

Molecular functions related to hair disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	copper ion binding	GO:005507	9.3	ATP7A, CP