MCID: HRD018
MIFTS: 41

Hair Disease malady

Skin diseases, Rare diseases categories
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Summaries for Hair Disease

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Sources:
8Disease Ontology, 34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 The average person has 5 million hairs. hair grows all over your body except on your lips, palms, and the soles of your feet. it takes about a month for healthy hair to grow half an inch. most hairs grow for up to six years and then fall out. new hairs grow in their place. hair helps keep you warm. it also protects your eyes, ears and nose from small particles in the air. common problem with the hair and scalp include hair loss, infections, and flaking.

MalaCards: Hair Disease, also known as hair disorder, is related to menkes disease and monilethrix. An important gene associated with Hair Disease is KRT86 (keratin 86). The compounds copper histidine and sodium azide have been mentioned in the context of this disorder. Affiliated tissues include hair, eye and brain.

Disease Ontology:8 An integumentary system disease that is located in hair.

Wikipedia:65 Hair diseases are disorders primarily associated with the follicles of the hair. more...

Aliases & Classifications for Hair Disease

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Sources:
8Disease Ontology, 45Novoseek, 34MedlinePlus, 62UMLS, 40NCIt, 35MeSH, 58SNOMED-CT, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases


Aliases & Descriptions:

hair disease 8
hair disorder 45
hair problems 34
hair diseases 62


External Ids:

Disease Ontology8 DOID:421
NCIt40 C34656
MeSH35 D006201
ICD1025 L67.9

Related Diseases for Hair Disease

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Hair Disease:



Diseases related to hair disease

Symptoms for Hair Disease

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Drugs & Therapeutics for Hair Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Hair Disease

Search NIH Clinical Center for Hair Disease

Genetic Tests for Hair Disease

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Anatomical Context for Hair Disease

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Sources:
33MalaCards, 14FMA
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MalaCards organs/tissues related to Hair Disease:

33
Eye, Brain, Cortex, Skin, Liver, Kidney, Thalamus, Placenta, Spinal cord, Cerebellum

FMA organs/tissues related to Hair Disease:

14
Hair

Animal Models for Hair Disease or affiliated genes

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Publications for Hair Disease

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Sources:
52PubMed
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Articles related to Hair Disease:

(show top 50)    (show all 95)
idTitleAuthorsYear
1
Menkes kinky hair disease. (23112368)
2012
2
Hair care practices and scalp/hair disease in African American girls. (21571179)
2011
3
Familial woolly hair disease. (20519796)
2010
4
Trichothiodystrophy and fragile hair: the distinction between diagnostic signs and diagnostic labels in childhood hair disease. (19754869)
2009
5
Menkes kinky hair disease: A case report. (18801184)
2008
6
Menkes kinky hair disease: an unusual case. (10872109)
2000
7
Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix. (9241275)
1997
8
Urologic abnormalities in Menkes' kinky hair disease: report of three cases. (9165480)
1997
9
Menkes' kinky hair disease associated with a large bladder diverticulum: a case report. (9255676)
1997
10
Menkes' Kinky Hair disease: new considerations. (9141833)
1996
11
Menkes' kinky-hair disease: radiologic findings in a patient treated with copper histidinate. (7704673)
1995
12
Menkes kinky hair disease. (8028455)
1994
13
Histochemical study of mitochondrial enzymes in cerebellar cortex of macular mutant mouse, a model of Menkes kinky hair disease. (8009964)
1994
14
The decreased immune responses in macular mouse, a model of Menkes' kinky hair disease. (8434133)
1993
15
Intracellular distribution of hepatic copper in macular mutant mice. An animal model of Menkes' kinky-hair disease. (7688531)
1993
16
Cytochrome C oxidase deficiency and neuronal involvement in Menkes' kinky hair disease: immunohistochemical study. (8293191)
1993
17
Effect of age and sex on copper-induced toxicity in the macular mutant mouse. An animal model for Menkes' kinky-hair disease. (7509170)
1993
18
Metallothionein messenger RNA levels in the macular mutant mouse: an animal model of Menkes' kinky-hair disease. (1912099)
1991
19
Copper-induced toxicity in macular mutant mouse: an animal model for Menkes' kinky-hair disease. (1871775)
1991
20
Menkes' kinky hair disease: morphological and immunohistochemical comparison of two autopsied patients. (2028748)
1991
21
A pathophysiological study of macular mutant mouse as a model of human Menkes kinky hair disease. I. Copper contents and copper dependent enzyme activities in various organs]. (2175632)
1990
22
Cerebral MR of Menkes kinky-hair disease. (2492723)
1989
23
Biochemical study on the brain of the macular mutant mouse as a model of Menkes' kinky hair disease. (2453126)
1988
24
Copper metabolism in the macular mutant mouse: an animal model of Menkes's kinky-hair disease. (3219371)
1988
25
Atypical Menkes steely hair disease. (3189407)
1988
26
Kinky hair disease: twenty five years later. (2839049)
1988
27
Light and electron microscopic study on cerebellar cortex of macular mutant mouse as a model of Menkes kinky hair disease. (2821841)
1987
28
Cerebral lipid and protein abnormalities in Menkes' steely-hair disease. (3599492)
1986
29
Structural changes of hair after incorporation of the proline analogue L-azetidine-2-carboxylic acid. A model of hair disease by alteration of primary structure. (2408388)
1985
30
Thalamic lesions in a patient with Menkes kinky-hair disease. (4064386)
1985
31
Menkes' kinky hair disease: clinical and experimental study. (4042823)
1985
32
Copper-binding proteins in the liver and kidney from the patients with Menkes' kinky hair disease. (6836561)
1983
33
Mitochondrial abnormalities in Menkes' kinky hair disease (MKHD). Electron-microscopic study of the brain from an autopsy case. (6868958)
1983
34
Autoradiographic demonstration of the copper-accumulating tissues in mice with a defect homologous to Menkes' Kinky Hair disease. (6417634)
1983
35
Histochemical studies of fibroblasts from patients with Menkes kinky hair disease and Wilson's disease. (6290431)
1982
36
Diagnosis of hair disease. (7232277)
1980
37
Kinky hair disease. Biochemical, histochemical, and ultrastructural studies. (514687)
1979
38
Failure of human milk therapy in Menkes' kinky hair disease. (581719)
1979
39
Inducibility of metallothionein biosynthesis in cultured normal and Menkes kinky hair disease fibroblasts: effects of copper and cadmium. (471576)
1979
40
Cell culture studies of Menkes kinky hair disease. (699339)
1978
41
Kinky hair disease. Report of a case. (282544)
1978
42
Metal-binding studies of metallothioneins in Menkes kinky hair disease. (699318)
1978
43
Inborn errors of copper metabolism: kinky hair disease and hepatolenticular degeneration. Therapeutic approaches. (979354)
1976
44
Neuropathologic aspects in Menkes' Kinky hair disease (trichopoliodystrophy). Menkes' Kinky hair disease. (4140481)
1974
45
Copper deficiency in the developing rat brain: a possible model for Menkes' steely-hair disease. (4368537)
1974
46
Letter: Menkes' kinky hair disease treated with subcutaneous copper sulphate. (4140440)
1974
47
Menkes' steely-hair (kinky-hair) disease. (4123446)
1973
48
Kinky hair disease. (5045346)
1972
49
The ocular pathology of Menkes' disease. (Kinky hair disease). (5699324)
1968
50
Kinky hair disease. I. Clinical and pathological features. (5922550)
1966

Variations for Hair Disease

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Expression for genes affiliated with Hair Disease

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hair Disease

Search GEO for disease gene expression data for Hair Disease.

Pathways for genes affiliated with Hair Disease

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Compounds for genes affiliated with Hair Disease

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Sources:
45Novoseek, 24HMDB, 11DrugBank
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Compounds related to Hair Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1copper histidine459.5COX5A, CP
2sodium azide459.5COX5A, CP
3carnitine459.4COX5A, CP
4sodium nitroprusside459.4CP, COX5A
5citrate459.3COX5A, CP
6copper45 2410.2COX5A, CP
7sucrose45 24 1110.8COX5A, CNP
8lipid458.5CNP, COX5A, CP
9glutamate458.2CP, COX5A, CNP, KRT86

GO Terms for genes affiliated with Hair Disease

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16Gene Ontology
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Cellular components related to Hair Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1keratin filamentGO:0450959.5KRT86, KRT81
2extracellular spaceGO:0056157.8KRT86, KRT81, CNP, CP

Molecular functions related to Hair Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural molecule activityGO:0051989.5KRT86, KRT81

Products for genes affiliated with Hair Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hair Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet