MCID: HLN001
MIFTS: 28

Halo Nevi malady

Summaries for Halo Nevi

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64Wikipedia, 33MalaCards
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Wikipedia:64 Halo nevus (also known as \"Leukoderma acquisitum centrifugum,\" \"Perinevoid vitiligo,\" and \"Sutton... more...

MalaCards: Halo Nevi, also known as leukoderma acquisitum centrifugum of sutton, is related to vitiligo and n syndrome. An important gene associated with Halo Nevi is HLA-DRB4 (major histocompatibility complex, class II, DR beta 4), and among its related pathways are Rheumatoid arthritis and Immune response T cell receptor signaling pathway. The compounds hemocyanin and l-dopa have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related mouse phenotype pigmentation.

Aliases & Classifications for Halo Nevi

Sources:
43NIH Rare Diseases, 61UMLS
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Aliases & Descriptions:

halo nevi 43
leukoderma acquisitum centrifugum of sutton 43
halo nevus 61


Related Diseases for Halo Nevi

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Halo Nevi:



Diseases related to halo nevi

Clinical Features for Halo Nevi

Drugs & Therapeutics for Halo Nevi

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Halo Nevi

Anatomical Context for Halo Nevi

Sources:
33MalaCards
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MalaCards organs/tissues related to Halo Nevi:

33
T cells

Animal Models for Halo Nevi or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
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MGI Mouse Phenotypes related to Halo Nevi:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.6TYR, MLANA, PMEL

Publications for Halo Nevi

Sources:
51PubMed
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Articles related to Halo Nevi:

(show all 36)
idTitleAuthorsYear
1
The natural history of halo nevi: a retrospective case series. (22387032)
2012
2
Halo nevi associated with interferon beta-1a therapy. (22445564)
2012
3
Halo nevi association in nonsegmental vitiligo affects age at onset and depigmentation pattern. (22508876)
2012
4
Foxp3(+) regulatory T cells are increased in the early stages of halo nevi: clinicopathological features of 30 halo nevi. (23006793)
2012
5
Cutaneous halo nevi following plaque radiotherapy for uveal melanoma. (22084224)
2011
6
"Halo nevi" and UV radiation. (21305746)
2010
7
Long term results of non cultured epidermal cellular grafting in vitiligo, halo nevi, piebaldism and nevus depigmentosus. (20560951)
2010
8
First histopathological and immunophenotypic analysis of early dynamic events in a patient with segmental vitiligo associated with halo nevi. (20370855)
2010
9
Halo nevi in Turner syndrome. (20653854)
2010
10
Halo nevi related to treatment with imatinib in a dermatofibrosarcoma protuberans patient. (19694892)
2010
11
Worsening alopecia areata and de novo occurrence of multiple halo nevi in a patient receiving infliximab. (18216487)
2008
12
Dermoscopy patterns of halo nevi. (17178990)
2006
13
Artifactual "pseudo-halo nevi" secondary to sunscreen application. (16713485)
2006
14
Typical halo nevi in childhood: is a biopsy necessary? Yes, but perhaps from the duodenum! (16227050)
2005
15
Difference in pathogenesis between vitiligo vulgaris and halo nevi associated with vitiligo is supported by an HLA association study. (15140072)
2004
16
Typical halo nevi in childhood: is a biopsy necessary? (11174633)
2001
17
Unusual halo nevi--darkening rather than lightening of the central nevus. (11455145)
2001
18
Immune-mediated destruction of melanocytes in halo nevi is associated with the local expansion of a limited number of T cell clones. (9973443)
1999
19
Presence of activated lymphocytes in the peripheral blood of patients with halo nevi. (10495377)
1999
20
The immune response in halo nevi. (9344203)
1997
21
Characterization of the mononuclear infiltrate involved in regression of halo nevi. (7798386)
1994
22
Analysis of major histocompatibility antigens and the mononuclear cell infiltrate in halo nevi. (3159801)
1985
23
Halo nevi and melanoma. (6464957)
1984
24
Vitiligo or halo nevi occurring in two patients with choroidal melanoma. (7059198)
1982
25
Comparison of cell-mediated immunity to melanoma cells in patients with vitiligo, halo nevi or melanoma. (7410884)
1980
26
Halo nevi and the Vogt-Koyanagi-Harada syndrome. Manifestations of vitiligo. (7377805)
1980
27
Halo nevi without dermal infiltrate. (718234)
1978
28
Letter: Malignant melanoma arising with two halo nevi. (1259452)
1976
29
Letter: Halo nevi of scalp with poliosis. (1267471)
1976
30
Ultrastructure of halo nevi. (1228211)
1975
31
Ultrastructural changes of mitochondria in pigmented and halo nevi. (4458608)
1974
32
Halo nevi and melanoma. (4741011)
1973
33
Multiple halo nevi. Histopathological findings in a 14-year-old boy. (5763200)
1969
34
Ultrastructure of halo nevi. (5659050)
1968
35
Halo nevi. (5659416)
1968
36
Multiple halo nevi in siblings. (5835331)
1965

Genetic Variations for Halo Nevi

Expression for genes affiliated with Halo Nevi

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Halo Nevi

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Pathways for genes affiliated with Halo Nevi

Sources:
30KEGG, 12EMD Millipore, 54Reactome, 52QIAGEN
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Compounds for genes affiliated with Halo Nevi

Sources:
45Novoseek, 29IUPHAR, 24HMDB
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Compounds related to Halo Nevi according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1hemocyanin459.4TYR, PMEL
2l-dopa29 2410.2SLC3A2, TYR
3dopachrome459.1TYR, PMEL

GO Terms for genes affiliated with Halo Nevi

Sources:
16Gene Ontology
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Cellular components related to Halo Nevi according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.8HLA-DRB1, HLA-DRB4
2clathrin-coated endocytic vesicle membraneGO:0306699.8HLA-DRB1, HLA-DRB4
3integral to lumenal side of endoplasmic reticulum membraneGO:0715569.7HLA-DRB1, HLA-DRB4
4ER to Golgi transport vesicle membraneGO:0125079.7HLA-DRB1, HLA-DRB4
5transport vesicle membraneGO:0306589.6HLA-DRB4, HLA-DRB1
6late endosome membraneGO:0319029.6HLA-DRB4, HLA-DRB1
7trans-Golgi network membraneGO:0325889.5HLA-DRB4, HLA-DRB1
8endocytic vesicle membraneGO:0306669.3HLA-DRB4, HLA-DRB1
9melanosomeGO:0424708.2SLC3A2, TYR, MLANA, PMEL

Biological processes related to Halo Nevi according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1regulation of interleukin-10 secretionGO:20011799.9HLA-DRB4, HLA-DRB1
2regulation of interleukin-4 productionGO:0326739.9HLA-DRB4, HLA-DRB1
3immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.9HLA-DRB1, HLA-DRB4
4humoral immune response mediated by circulating immunoglobulinGO:0024559.9HLA-DRB4, HLA-DRB1
5T-helper 1 type immune responseGO:0420889.9HLA-DRB4, HLA-DRB1
6inflammatory response to antigenic stimulusGO:0024379.8HLA-DRB1, HLA-DRB4
7positive regulation of insulin secretion involved in cellular response to glucose stimulusGO:0357749.8HLA-DRB4, HLA-DRB1
8detection of bacteriumGO:0160459.8HLA-DRB1, HLA-DRB4
9negative regulation of interferon-gamma productionGO:0326899.8HLA-DRB1, HLA-DRB4
10negative regulation of T cell proliferationGO:0421309.7HLA-DRB1, HLA-DRB4
11protein tetramerizationGO:0512629.7HLA-DRB1, HLA-DRB4
12interferon-gamma-mediated signaling pathwayGO:0603339.6HLA-DRB4, HLA-DRB1
13antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198869.6HLA-DRB4, HLA-DRB1
14T cell costimulationGO:0312959.5HLA-DRB4, HLA-DRB1
15T cell receptor signaling pathwayGO:0508529.3HLA-DRB1, HLA-DRB4

Molecular functions related to Halo Nevi according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:0426059.6HLA-DRB1, HLA-DRB4
2MHC class II receptor activityGO:0323959.3HLA-DRB1, HLA-DRB4

Products for genes affiliated with Halo Nevi

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  • Proteins
  • Lysates
  • Antibodies

Sources for Halo Nevi

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet