MCID: HLN001
MIFTS: 26

Halo Nevi malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Halo Nevi

Aliases & Descriptions for Halo Nevi:

Name: Halo Nevi 50
Leukoderma Acquisitum Centrifugum of Sutton 50
Halo Nevus 69

Classifications:



Summaries for Halo Nevi

MalaCards based summary : Halo Nevi, also known as leukoderma acquisitum centrifugum of sutton, is related to melanoma and learning disability. An important gene associated with Halo Nevi is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Translocation of ZAP-70 to Immunological synapse and MHC class II antigen presentation. Affiliated tissues include t cells and skin, and related phenotype is pigmentation.

Related Diseases for Halo Nevi

Graphical network of the top 20 diseases related to Halo Nevi:



Diseases related to Halo Nevi

Symptoms & Phenotypes for Halo Nevi

MGI Mouse Phenotypes related to Halo Nevi:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 pigmentation MP:0001186 8.8 PMEL TYR MLANA

Drugs & Therapeutics for Halo Nevi

Search Clinical Trials , NIH Clinical Center for Halo Nevi

Genetic Tests for Halo Nevi

Anatomical Context for Halo Nevi

MalaCards organs/tissues related to Halo Nevi:

39
T Cells, Skin

Publications for Halo Nevi

Articles related to Halo Nevi:

(show all 40)
id Title Authors Year
1
Alopecia, halo nevi and vitiligo in a pediatric case of Turner's syndrome. ( 27238352 )
2016
2
Multiple halo nevi subsequent to a short period of sunbathing. ( 25703501 )
2015
3
A comparative study of mitochondrial ultrastructure in melanocytes from perilesional vitiligo skin and perilesional halo nevi skin. ( 25672813 )
2015
4
Comparison of Childhood Vitiligo Presenting with or without Associated Halo Nevi. ( 26573093 )
2015
5
Study of the Immunophenotype of the Inflammatory Cells in Melanomas With Regression and Halo Nevi. ( 25222195 )
2014
6
Spontaneous partial repigmentation of halo nevi around congenital melanocytic nevus and vitiligo in a 13-year-old boy. ( 24448132 )
2014
7
Halo nevi associated with interferon beta-1a therapy. ( 22445564 )
2012
8
Foxp3(+) regulatory T cells are increased in the early stages of halo nevi: clinicopathological features of 30 halo nevi. ( 23006793 )
2012
9
The natural history of halo nevi: a retrospective case series. ( 22387032 )
2012
10
Halo nevi association in nonsegmental vitiligo affects age at onset and depigmentation pattern. ( 22508876 )
2012
11
Cutaneous halo nevi following plaque radiotherapy for uveal melanoma. ( 22084224 )
2011
12
Long term results of non cultured epidermal cellular grafting in vitiligo, halo nevi, piebaldism and nevus depigmentosus. ( 20560951 )
2010
13
First histopathological and immunophenotypic analysis of early dynamic events in a patient with segmental vitiligo associated with halo nevi. ( 20370855 )
2010
14
Halo nevi in Turner syndrome. ( 20653854 )
2010
15
Halo nevi related to treatment with imatinib in a dermatofibrosarcoma protuberans patient. ( 19694892 )
2010
16
Worsening alopecia areata and de novo occurrence of multiple halo nevi in a patient receiving infliximab. ( 18216487 )
2008
17
Dermoscopy patterns of halo nevi. ( 17178990 )
2006
18
Typical halo nevi in childhood: is a biopsy necessary? Yes, but perhaps from the duodenum! ( 16227050 )
2005
19
Difference in pathogenesis between vitiligo vulgaris and halo nevi associated with vitiligo is supported by an HLA association study. ( 15140072 )
2004
20
Typical halo nevi in childhood: is a biopsy necessary? ( 11174633 )
2001
21
Unusual halo nevi--darkening rather than lightening of the central nevus. ( 11455145 )
2001
22
Presence of activated lymphocytes in the peripheral blood of patients with halo nevi. ( 10495377 )
1999
23
Immune-mediated destruction of melanocytes in halo nevi is associated with the local expansion of a limited number of T cell clones. ( 9973443 )
1999
24
The immune response in halo nevi. ( 9344203 )
1997
25
Characterization of the mononuclear infiltrate involved in regression of halo nevi. ( 7798386 )
1994
26
Analysis of major histocompatibility antigens and the mononuclear cell infiltrate in halo nevi. ( 3159801 )
1985
27
Halo nevi and melanoma. ( 6464957 )
1984
28
Vitiligo or halo nevi occurring in two patients with choroidal melanoma. ( 7059198 )
1982
29
Halo nevi and the Vogt-Koyanagi-Harada syndrome. Manifestations of vitiligo. ( 7377805 )
1980
30
Comparison of cell-mediated immunity to melanoma cells in patients with vitiligo, halo nevi or melanoma. ( 7410884 )
1980
31
Halo nevi without dermal infiltrate. ( 718234 )
1978
32
Letter: Halo nevi of scalp with poliosis. ( 1267471 )
1976
33
Letter: Malignant melanoma arising with two halo nevi. ( 1259452 )
1976
34
Ultrastructure of halo nevi. ( 1228211 )
1975
35
Ultrastructural changes of mitochondria in pigmented and halo nevi. ( 4458608 )
1974
36
Halo nevi and melanoma. ( 4741011 )
1973
37
Multiple halo nevi. Histopathological findings in a 14-year-old boy. ( 5763200 )
1969
38
Ultrastructure of halo nevi. ( 5659050 )
1968
39
Halo nevi. ( 5659416 )
1968
40
Multiple halo nevi in siblings. ( 5835331 )
1965

Variations for Halo Nevi

Expression for Halo Nevi

Search GEO for disease gene expression data for Halo Nevi.

Pathways for Halo Nevi

GO Terms for Halo Nevi

Cellular components related to Halo Nevi according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 late endosome membrane GO:0031902 9.46 HLA-DRB1 HLA-DRB4
2 trans-Golgi network membrane GO:0032588 9.43 HLA-DRB1 HLA-DRB4
3 endocytic vesicle membrane GO:0030666 9.4 HLA-DRB1 HLA-DRB4
4 ER to Golgi transport vesicle membrane GO:0012507 9.37 HLA-DRB1 HLA-DRB4
5 transport vesicle membrane GO:0030658 9.32 HLA-DRB1 HLA-DRB4
6 clathrin-coated endocytic vesicle membrane GO:0030669 9.26 HLA-DRB1 HLA-DRB4
7 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.16 HLA-DRB1 HLA-DRB4
8 MHC class II protein complex GO:0042613 8.96 HLA-DRB1 HLA-DRB4
9 melanosome GO:0042470 8.92 MLANA PMEL SLC3A2 TYR

Biological processes related to Halo Nevi according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.26 HLA-DRB1 HLA-DRB4
2 T cell costimulation GO:0031295 9.16 HLA-DRB1 HLA-DRB4
3 interferon-gamma-mediated signaling pathway GO:0060333 8.96 HLA-DRB1 HLA-DRB4
4 melanin biosynthetic process GO:0042438 8.62 PMEL TYR

Sources for Halo Nevi

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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