MCID: HLN001
MIFTS: 26

Halo Nevi malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Halo Nevi

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Aliases & Descriptions for Halo Nevi:

Name: Halo Nevi 46
Leukoderma Acquisitum Centrifugum of Sutton 46
 
Halo Nevus 66

Classifications:



Summaries for Halo Nevi

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MalaCards based summary: Halo Nevi, also known as leukoderma acquisitum centrifugum of sutton, is related to melanoma and mitochondrial encephalomyopathy. An important gene associated with Halo Nevi is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways are Translocation of ZAP-70 to Immunological synapse and Immune response Antigen presentation by MHC class II. Affiliated tissues include t cells and skin, and related mouse phenotype pigmentation.

Related Diseases for Halo Nevi

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Graphical network of the top 20 diseases related to Halo Nevi:



Diseases related to halo nevi

Symptoms for Halo Nevi

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Drugs & Therapeutics for Halo Nevi

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Halo Nevi

Genetic Tests for Halo Nevi

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Anatomical Context for Halo Nevi

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MalaCards organs/tissues related to Halo Nevi:

34
T cells, Skin

Animal Models for Halo Nevi or affiliated genes

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MGI Mouse Phenotypes related to Halo Nevi:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.8MLANA, PMEL, TYR

Publications for Halo Nevi

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Articles related to Halo Nevi:

(show all 40)
idTitleAuthorsYear
1
Alopecia, halo nevi and vitiligo in a pediatric case of Turner's syndrome. (27238352)
2016
2
Comparison of Childhood Vitiligo Presenting with or without Associated Halo Nevi. (26573093)
2015
3
Multiple halo nevi subsequent to a short period of sunbathing. (25703501)
2015
4
A comparative study of mitochondrial ultrastructure in melanocytes from perilesional vitiligo skin and perilesional halo nevi skin. (25672813)
2015
5
Study of the Immunophenotype of the Inflammatory Cells in Melanomas With Regression and Halo Nevi. (25222195)
2014
6
Spontaneous partial repigmentation of halo nevi around congenital melanocytic nevus and vitiligo in a 13-year-old boy. (24448132)
2014
7
Halo nevi associated with interferon beta-1a therapy. (22445564)
2012
8
Halo nevi association in nonsegmental vitiligo affects age at onset and depigmentation pattern. (22508876)
2012
9
The natural history of halo nevi: a retrospective case series. (22387032)
2012
10
Foxp3(+) regulatory T cells are increased in the early stages of halo nevi: clinicopathological features of 30 halo nevi. (23006793)
2012
11
Cutaneous halo nevi following plaque radiotherapy for uveal melanoma. (22084224)
2011
12
Long term results of non cultured epidermal cellular grafting in vitiligo, halo nevi, piebaldism and nevus depigmentosus. (20560951)
2010
13
Halo nevi related to treatment with imatinib in a dermatofibrosarcoma protuberans patient. (19694892)
2010
14
First histopathological and immunophenotypic analysis of early dynamic events in a patient with segmental vitiligo associated with halo nevi. (20370855)
2010
15
Halo nevi in Turner syndrome. (20653854)
2010
16
Worsening alopecia areata and de novo occurrence of multiple halo nevi in a patient receiving infliximab. (18216487)
2008
17
Dermoscopy patterns of halo nevi. (17178990)
2006
18
Typical halo nevi in childhood: is a biopsy necessary? Yes, but perhaps from the duodenum! (16227050)
2005
19
Difference in pathogenesis between vitiligo vulgaris and halo nevi associated with vitiligo is supported by an HLA association study. (15140072)
2004
20
Typical halo nevi in childhood: is a biopsy necessary? (11174633)
2001
21
Unusual halo nevi--darkening rather than lightening of the central nevus. (11455145)
2001
22
Immune-mediated destruction of melanocytes in halo nevi is associated with the local expansion of a limited number of T cell clones. (9973443)
1999
23
Presence of activated lymphocytes in the peripheral blood of patients with halo nevi. (10495377)
1999
24
The immune response in halo nevi. (9344203)
1997
25
Characterization of the mononuclear infiltrate involved in regression of halo nevi. (7798386)
1994
26
Analysis of major histocompatibility antigens and the mononuclear cell infiltrate in halo nevi. (3159801)
1985
27
Halo nevi and melanoma. (6464957)
1984
28
Vitiligo or halo nevi occurring in two patients with choroidal melanoma. (7059198)
1982
29
Comparison of cell-mediated immunity to melanoma cells in patients with vitiligo, halo nevi or melanoma. (7410884)
1980
30
Halo nevi and the Vogt-Koyanagi-Harada syndrome. Manifestations of vitiligo. (7377805)
1980
31
Halo nevi without dermal infiltrate. (718234)
1978
32
Letter: Malignant melanoma arising with two halo nevi. (1259452)
1976
33
Letter: Halo nevi of scalp with poliosis. (1267471)
1976
34
Ultrastructure of halo nevi. (1228211)
1975
35
Ultrastructural changes of mitochondria in pigmented and halo nevi. (4458608)
1974
36
Halo nevi and melanoma. (4741011)
1973
37
Multiple halo nevi. Histopathological findings in a 14-year-old boy. (5763200)
1969
38
Ultrastructure of halo nevi. (5659050)
1968
39
Halo nevi. (5659416)
1968
40
Multiple halo nevi in siblings. (5835331)
1965

Variations for Halo Nevi

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Expression for genes affiliated with Halo Nevi

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Search GEO for disease gene expression data for Halo Nevi.

Pathways for genes affiliated with Halo Nevi

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GO Terms for genes affiliated with Halo Nevi

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Cellular components related to Halo Nevi according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:004261310.1HLA-DRB1, HLA-DRB4
2integral component of lumenal side of endoplasmic reticulum membraneGO:007155610.1HLA-DRB1, HLA-DRB4
3clathrin-coated endocytic vesicle membraneGO:003066910.0HLA-DRB1, HLA-DRB4
4ER to Golgi transport vesicle membraneGO:00125079.9HLA-DRB1, HLA-DRB4
5trans-Golgi network membraneGO:00325889.9HLA-DRB1, HLA-DRB4
6late endosome membraneGO:00319029.8HLA-DRB1, HLA-DRB4
7transport vesicle membraneGO:00306589.7HLA-DRB1, HLA-DRB4
8endocytic vesicle membraneGO:00306669.3HLA-DRB1, HLA-DRB4
9melanosomeGO:00424708.0MLANA, PMEL, SLC3A2, TYR

Biological processes related to Halo Nevi according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1interferon-gamma-mediated signaling pathwayGO:006033310.0HLA-DRB1, HLA-DRB4
2T cell costimulationGO:00312959.6HLA-DRB1, HLA-DRB4
3melanin biosynthetic processGO:00424389.5PMEL, TYR
4antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198869.3HLA-DRB1, HLA-DRB4

Sources for Halo Nevi

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet