MCID: HLN001
MIFTS: 26

Halo Nevi malady

Rare diseases, Skin diseases categories

Aliases & Classifications for Halo Nevi

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Aliases & Descriptions for Halo Nevi:

Name: Halo Nevi 45
Leukoderma Acquisitum Centrifugum of Sutton 45
 
Halo Nevus 65


Classifications:



Summaries for Halo Nevi

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Wikipedia:68 Halo nevus (also known as \"Leukoderma acquisitum centrifugum,\" \"Perinevoid vitiligo,\" and \"Sutton... more...

MalaCards based summary: Halo Nevi, also known as leukoderma acquisitum centrifugum of sutton, is related to melanoma and piebaldism. An important gene associated with Halo Nevi is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways are MHC class II antigen presentation and Translocation of ZAP-70 to Immunological synapse. Affiliated tissues include skin and t cells, and related mouse phenotype pigmentation.

Related Diseases for Halo Nevi

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Graphical network of the top 20 diseases related to Halo Nevi:



Diseases related to halo nevi

Symptoms for Halo Nevi

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Drugs & Therapeutics for Halo Nevi

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Halo Nevi

Genetic Tests for Halo Nevi

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Anatomical Context for Halo Nevi

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MalaCards organs/tissues related to Halo Nevi:

33
Skin, T cells

Animal Models for Halo Nevi or affiliated genes

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MGI Mouse Phenotypes related to Halo Nevi:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.7MLANA, PMEL, TYR

Publications for Halo Nevi

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Articles related to Halo Nevi:

(show all 38)
idTitleAuthorsYear
1
Comparison of Childhood Vitiligo Presenting with or without Associated Halo Nevi. (26573093)
2015
2
Multiple halo nevi subsequent to a short period of sunbathing. (25703501)
2015
3
A comparative study of mitochondrial ultrastructure in melanocytes from perilesional vitiligo skin and perilesional halo nevi skin. (25672813)
2015
4
Study of the Immunophenotype of the Inflammatory Cells in Melanomas With Regression and Halo Nevi. (25222195)
2014
5
Spontaneous partial repigmentation of halo nevi around congenital melanocytic nevus and vitiligo in a 13-year-old boy. (24448132)
2014
6
The natural history of halo nevi: a retrospective case series. (22387032)
2012
7
Halo nevi associated with interferon beta-1a therapy. (22445564)
2012
8
Halo nevi association in nonsegmental vitiligo affects age at onset and depigmentation pattern. (22508876)
2012
9
Foxp3(+) regulatory T cells are increased in the early stages of halo nevi: clinicopathological features of 30 halo nevi. (23006793)
2012
10
Cutaneous halo nevi following plaque radiotherapy for uveal melanoma. (22084224)
2011
11
Long term results of non cultured epidermal cellular grafting in vitiligo, halo nevi, piebaldism and nevus depigmentosus. (20560951)
2010
12
First histopathological and immunophenotypic analysis of early dynamic events in a patient with segmental vitiligo associated with halo nevi. (20370855)
2010
13
Halo nevi in Turner syndrome. (20653854)
2010
14
Worsening alopecia areata and de novo occurrence of multiple halo nevi in a patient receiving infliximab. (18216487)
2008
15
Dermoscopy patterns of halo nevi. (17178990)
2006
16
Typical halo nevi in childhood: is a biopsy necessary? Yes, but perhaps from the duodenum! (16227050)
2005
17
Difference in pathogenesis between vitiligo vulgaris and halo nevi associated with vitiligo is supported by an HLA association study. (15140072)
2004
18
Typical halo nevi in childhood: is a biopsy necessary? (11174633)
2001
19
Unusual halo nevi--darkening rather than lightening of the central nevus. (11455145)
2001
20
Immune-mediated destruction of melanocytes in halo nevi is associated with the local expansion of a limited number of T cell clones. (9973443)
1999
21
Presence of activated lymphocytes in the peripheral blood of patients with halo nevi. (10495377)
1999
22
The immune response in halo nevi. (9344203)
1997
23
Characterization of the mononuclear infiltrate involved in regression of halo nevi. (7798386)
1994
24
Analysis of major histocompatibility antigens and the mononuclear cell infiltrate in halo nevi. (3159801)
1985
25
Halo nevi and melanoma. (6464957)
1984
26
Vitiligo or halo nevi occurring in two patients with choroidal melanoma. (7059198)
1982
27
Comparison of cell-mediated immunity to melanoma cells in patients with vitiligo, halo nevi or melanoma. (7410884)
1980
28
Halo nevi and the Vogt-Koyanagi-Harada syndrome. Manifestations of vitiligo. (7377805)
1980
29
Halo nevi without dermal infiltrate. (718234)
1978
30
Letter: Malignant melanoma arising with two halo nevi. (1259452)
1976
31
Letter: Halo nevi of scalp with poliosis. (1267471)
1976
32
Ultrastructure of halo nevi. (1228211)
1975
33
Ultrastructural changes of mitochondria in pigmented and halo nevi. (4458608)
1974
34
Halo nevi and melanoma. (4741011)
1973
35
Multiple halo nevi. Histopathological findings in a 14-year-old boy. (5763200)
1969
36
Ultrastructure of halo nevi. (5659050)
1968
37
Halo nevi. (5659416)
1968
38
Multiple halo nevi in siblings. (5835331)
1965

Variations for Halo Nevi

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Expression for genes affiliated with Halo Nevi

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Search GEO for disease gene expression data for Halo Nevi.

Pathways for genes affiliated with Halo Nevi

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GO Terms for genes affiliated with Halo Nevi

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Cellular components related to Halo Nevi according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:00426139.8HLA-DRB1, HLA-DRB4
2integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.8HLA-DRB1, HLA-DRB4
3ER to Golgi transport vesicle membraneGO:00125079.7HLA-DRB1, HLA-DRB4
4late endosome membraneGO:00319029.7HLA-DRB1, HLA-DRB4
5endocytic vesicle membraneGO:00306669.7HLA-DRB1, HLA-DRB4
6clathrin-coated endocytic vesicle membraneGO:00306699.6HLA-DRB1, HLA-DRB4
7trans-Golgi network membraneGO:00325889.5HLA-DRB1, HLA-DRB4
8transport vesicle membraneGO:00306589.5HLA-DRB1, HLA-DRB4
9melanosomeGO:00424708.0MLANA, PMEL, SLC3A2, TYR

Biological processes related to Halo Nevi according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1regulation of interleukin-10 secretionGO:200117910.2HLA-DRB1, HLA-DRB4
2peptide antigen assembly with MHC class II protein complexGO:000250310.1HLA-DRB1, HLA-DRB4
3regulation of interleukin-4 productionGO:003267310.1HLA-DRB1, HLA-DRB4
4inflammatory response to antigenic stimulusGO:000243710.1HLA-DRB1, HLA-DRB4
5immunoglobulin production involved in immunoglobulin mediated immune responseGO:000238110.0HLA-DRB1, HLA-DRB4
6detection of bacteriumGO:001604510.0HLA-DRB1, HLA-DRB4
7T-helper 1 type immune responseGO:004208810.0HLA-DRB1, HLA-DRB4
8humoral immune response mediated by circulating immunoglobulinGO:00024559.9HLA-DRB1, HLA-DRB4
9negative regulation of interferon-gamma productionGO:00326899.9HLA-DRB1, HLA-DRB4
10interferon-gamma-mediated signaling pathwayGO:00603339.9HLA-DRB1, HLA-DRB4
11negative regulation of T cell proliferationGO:00421309.8HLA-DRB1, HLA-DRB4
12T cell costimulationGO:00312959.7HLA-DRB1, HLA-DRB4
13positive regulation of insulin secretion involved in cellular response to glucose stimulusGO:00357749.7HLA-DRB1, HLA-DRB4
14protein tetramerizationGO:00512629.5HLA-DRB1, HLA-DRB4
15melanin biosynthetic processGO:00424389.4PMEL, TYR
16antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198869.2HLA-DRB1, HLA-DRB4

Molecular functions related to Halo Nevi according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II receptor activityGO:00323959.8HLA-DRB1, HLA-DRB4
2peptide antigen bindingGO:00426059.5HLA-DRB1, HLA-DRB4

Sources for Halo Nevi

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet