MCID: HLN001
MIFTS: 30

Halo Nevi malady

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Halo Nevi

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Aliases & Descriptions for Halo Nevi:

Name: Halo Nevi 45
Leukoderma Acquisitum Centrifugum of Sutton 45
 
Halo Nevus 65

Classifications:



External Ids:

UMLS65 C0474824

Summaries for Halo Nevi

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MalaCards based summary: Halo Nevi, also known as leukoderma acquisitum centrifugum of sutton, is related to melanoma and dermatofibrosarcoma protuberans. An important gene associated with Halo Nevi is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways are Epstein-Barr virus infection and Toxoplasmosis. Affiliated tissues include prostate, t cells and skin.

Related Diseases for Halo Nevi

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Diseases related to Halo Nevi via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
idRelated DiseaseScoreTop Affiliating Genes
1melanoma10.3
2dermatofibrosarcoma protuberans9.9
3piebaldism9.9
4alopecia9.9
5choroiditis9.9
6turner syndrome9.9
7uveal melanoma9.9
8alopecia areata9.9
9hepatoid adenocarcinoma9.4HLA-DRB1, HLA-DRB4
10psoriasis9.2HLA-DRB1, HLA-DRB4
11hamanishi ueba tsuji syndrome8.8HLA-DRB1, HLA-DRB4, SLC3A2

Graphical network of diseases related to Halo Nevi:



Diseases related to halo nevi

Symptoms for Halo Nevi

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Drugs & Therapeutics for Halo Nevi

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Halo Nevi

Genetic Tests for Halo Nevi

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Anatomical Context for Halo Nevi

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MalaCards organs/tissues related to Halo Nevi:

33
Prostate, T cells, Skin, Myeloid, Testis, Lung, Skeletal muscle

Animal Models for Halo Nevi or affiliated genes

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MGI Mouse Phenotypes related to Halo Nevi:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes

Publications for Halo Nevi

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Articles related to Halo Nevi:

(show all 39)
idTitleAuthorsYear
1
Comparison of Childhood Vitiligo Presenting with or without Associated Halo Nevi. (26573093)
2015
2
Multiple halo nevi subsequent to a short period of sunbathing. (25703501)
2015
3
A comparative study of mitochondrial ultrastructure in melanocytes from perilesional vitiligo skin and perilesional halo nevi skin. (25672813)
2015
4
Study of the Immunophenotype of the Inflammatory Cells in Melanomas With Regression and Halo Nevi. (25222195)
2014
5
Spontaneous partial repigmentation of halo nevi around congenital melanocytic nevus and vitiligo in a 13-year-old boy. (24448132)
2014
6
The natural history of halo nevi: a retrospective case series. (22387032)
2012
7
Halo nevi associated with interferon beta-1a therapy. (22445564)
2012
8
Halo nevi association in nonsegmental vitiligo affects age at onset and depigmentation pattern. (22508876)
2012
9
Foxp3(+) regulatory T cells are increased in the early stages of halo nevi: clinicopathological features of 30 halo nevi. (23006793)
2012
10
Cutaneous halo nevi following plaque radiotherapy for uveal melanoma. (22084224)
2011
11
Long term results of non cultured epidermal cellular grafting in vitiligo, halo nevi, piebaldism and nevus depigmentosus. (20560951)
2010
12
First histopathological and immunophenotypic analysis of early dynamic events in a patient with segmental vitiligo associated with halo nevi. (20370855)
2010
13
Halo nevi in Turner syndrome. (20653854)
2010
14
Halo nevi related to treatment with imatinib in a dermatofibrosarcoma protuberans patient. (19694892)
2010
15
Worsening alopecia areata and de novo occurrence of multiple halo nevi in a patient receiving infliximab. (18216487)
2008
16
Dermoscopy patterns of halo nevi. (17178990)
2006
17
Typical halo nevi in childhood: is a biopsy necessary? Yes, but perhaps from the duodenum! (16227050)
2005
18
Difference in pathogenesis between vitiligo vulgaris and halo nevi associated with vitiligo is supported by an HLA association study. (15140072)
2004
19
Typical halo nevi in childhood: is a biopsy necessary? (11174633)
2001
20
Unusual halo nevi--darkening rather than lightening of the central nevus. (11455145)
2001
21
Immune-mediated destruction of melanocytes in halo nevi is associated with the local expansion of a limited number of T cell clones. (9973443)
1999
22
Presence of activated lymphocytes in the peripheral blood of patients with halo nevi. (10495377)
1999
23
The immune response in halo nevi. (9344203)
1997
24
Characterization of the mononuclear infiltrate involved in regression of halo nevi. (7798386)
1994
25
Analysis of major histocompatibility antigens and the mononuclear cell infiltrate in halo nevi. (3159801)
1985
26
Halo nevi and melanoma. (6464957)
1984
27
Vitiligo or halo nevi occurring in two patients with choroidal melanoma. (7059198)
1982
28
Comparison of cell-mediated immunity to melanoma cells in patients with vitiligo, halo nevi or melanoma. (7410884)
1980
29
Halo nevi and the Vogt-Koyanagi-Harada syndrome. Manifestations of vitiligo. (7377805)
1980
30
Halo nevi without dermal infiltrate. (718234)
1978
31
Letter: Malignant melanoma arising with two halo nevi. (1259452)
1976
32
Letter: Halo nevi of scalp with poliosis. (1267471)
1976
33
Ultrastructure of halo nevi. (1228211)
1975
34
Ultrastructural changes of mitochondria in pigmented and halo nevi. (4458608)
1974
35
Halo nevi and melanoma. (4741011)
1973
36
Multiple halo nevi. Histopathological findings in a 14-year-old boy. (5763200)
1969
37
Ultrastructure of halo nevi. (5659050)
1968
38
Halo nevi. (5659416)
1968
39
Multiple halo nevi in siblings. (5835331)
1965

Variations for Halo Nevi

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Expression for genes affiliated with Halo Nevi

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Search GEO for disease gene expression data for Halo Nevi.

Pathways for genes affiliated with Halo Nevi

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Pathways related to Halo Nevi according to GeneCards Suite gene sharing:

(show all 18)
idSuper pathwaysScoreTop Affiliating Genes
19.0HLA-DRB1, HLA-DRB4
2
Show member pathways
9.0HLA-DRB1, HLA-DRB4
3
Show member pathways
9.0HLA-DRB1, HLA-DRB4
4
Show member pathways
9.0HLA-DRB1, HLA-DRB4
5
Show member pathways
9.0HLA-DRB1, HLA-DRB4
6
Show member pathways
9.0HLA-DRB1, HLA-DRB4
7
Show member pathways
9.0HLA-DRB1, HLA-DRB4
89.0HLA-DRB1, HLA-DRB4
99.0HLA-DRB1, HLA-DRB4
10
Show member pathways
9.0HLA-DRB1, HLA-DRB4
119.0HLA-DRB1, HLA-DRB4
129.0HLA-DRB1, HLA-DRB4
139.0HLA-DRB1, HLA-DRB4
149.0HLA-DRB1, HLA-DRB4
15
Show member pathways
9.0HLA-DRB1, HLA-DRB4
169.0HLA-DRB1, HLA-DRB4
179.0HLA-DRB1, HLA-DRB4
189.0HLA-DRB1, HLA-DRB4

GO Terms for genes affiliated with Halo Nevi

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Cellular components related to Halo Nevi according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ER to Golgi transport vesicle membraneGO:00125079.1HLA-DRB1, HLA-DRB4
2external side of plasma membraneGO:00098979.0HLA-DRB1, HLA-DRB4
3trans-Golgi network membraneGO:00325888.9HLA-DRB1, HLA-DRB4

Biological processes related to Halo Nevi according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1immunoglobulin production involved in immunoglobulin mediated immune responseGO:00023819.6HLA-DRB1, HLA-DRB4
2peptide antigen assembly with MHC class II protein complexGO:00025039.6HLA-DRB1, HLA-DRB4
3regulation of interleukin-10 secretionGO:20011799.6HLA-DRB1, HLA-DRB4
4T-helper 1 type immune responseGO:00420889.6HLA-DRB1, HLA-DRB4
5humoral immune response mediated by circulating immunoglobulinGO:00024559.4HLA-DRB1, HLA-DRB4
6immune responseGO:00069559.0HLA-DRB1, HLA-DRB4

Sources for Halo Nevi

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet