MCID: HLN001
MIFTS: 33

Halo Nevi malady

Rare diseases, Skin diseases categories

Summaries for Halo Nevi

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66Wikipedia, 34MalaCards
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Wikipedia:66 Halo nevus (also known as \"Leukoderma acquisitum centrifugum,\" \"Perinevoid vitiligo,\" and \"Sutton... more...

MalaCards: Halo Nevi, also known as leukoderma acquisitum centrifugum of sutton, is related to vitiligo and melanoma. An important gene associated with Halo Nevi is HLA-DRB4 (major histocompatibility complex, class II, DR beta 4), and among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CD28 co-stimulation. The compounds l-dopa and dopachrome have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related mouse phenotype pigmentation.

Aliases & Classifications for Halo Nevi

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44NIH Rare Diseases, 63UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases


Aliases & Descriptions:

halo nevi 44
leukoderma acquisitum centrifugum of sutton 44
halo nevus 63


Related Diseases for Halo Nevi

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18GeneCards, 19GeneDecks
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Graphical network of diseases related to Halo Nevi:



Diseases related to halo nevi

Symptoms for Halo Nevi

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Drugs & Therapeutics for Halo Nevi

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Halo Nevi

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Anatomical Context for Halo Nevi

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34MalaCards
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MalaCards organs/tissues related to Halo Nevi:

34
T cells

Animal Models for Halo Nevi or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Halo Nevi:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.6PMEL, TYR, MLANA

Publications for Halo Nevi

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53PubMed
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Articles related to Halo Nevi:

(show all 33)
idTitleAuthorsYear
1
The natural history of halo nevi: a retrospective case series. (22387032)
2012
2
Halo nevi associated with interferon beta-1a therapy. (22445564)
2012
3
Halo nevi association in nonsegmental vitiligo affects age at onset and depigmentation pattern. (22508876)
2012
4
Foxp3(+) regulatory T cells are increased in the early stages of halo nevi: clinicopathological features of 30 halo nevi. (23006793)
2012
5
Cutaneous halo nevi following plaque radiotherapy for uveal melanoma. (22084224)
2011
6
Long term results of non cultured epidermal cellular grafting in vitiligo, halo nevi, piebaldism and nevus depigmentosus. (20560951)
2010
7
First histopathological and immunophenotypic analysis of early dynamic events in a patient with segmental vitiligo associated with halo nevi. (20370855)
2010
8
Halo nevi in Turner syndrome. (20653854)
2010
9
Halo nevi related to treatment with imatinib in a dermatofibrosarcoma protuberans patient. (19694892)
2010
10
Worsening alopecia areata and de novo occurrence of multiple halo nevi in a patient receiving infliximab. (18216487)
2008
11
Dermoscopy patterns of halo nevi. (17178990)
2006
12
Typical halo nevi in childhood: is a biopsy necessary? Yes, but perhaps from the duodenum! (16227050)
2005
13
Difference in pathogenesis between vitiligo vulgaris and halo nevi associated with vitiligo is supported by an HLA association study. (15140072)
2004
14
Typical halo nevi in childhood: is a biopsy necessary? (11174633)
2001
15
Unusual halo nevi--darkening rather than lightening of the central nevus. (11455145)
2001
16
Immune-mediated destruction of melanocytes in halo nevi is associated with the local expansion of a limited number of T cell clones. (9973443)
1999
17
Presence of activated lymphocytes in the peripheral blood of patients with halo nevi. (10495377)
1999
18
The immune response in halo nevi. (9344203)
1997
19
Characterization of the mononuclear infiltrate involved in regression of halo nevi. (7798386)
1994
20
Analysis of major histocompatibility antigens and the mononuclear cell infiltrate in halo nevi. (3159801)
1985
21
Halo nevi and melanoma. (6464957)
1984
22
Vitiligo or halo nevi occurring in two patients with choroidal melanoma. (7059198)
1982
23
Comparison of cell-mediated immunity to melanoma cells in patients with vitiligo, halo nevi or melanoma. (7410884)
1980
24
Halo nevi and the Vogt-Koyanagi-Harada syndrome. Manifestations of vitiligo. (7377805)
1980
25
Halo nevi without dermal infiltrate. (718234)
1978
26
Letter: Malignant melanoma arising with two halo nevi. (1259452)
1976
27
Ultrastructure of halo nevi. (1228211)
1975
28
Ultrastructural changes of mitochondria in pigmented and halo nevi. (4458608)
1974
29
Halo nevi and melanoma. (4741011)
1973
30
Multiple halo nevi. Histopathological findings in a 14-year-old boy. (5763200)
1969
31
Ultrastructure of halo nevi. (5659050)
1968
32
Halo nevi. (5659416)
1968
33
Multiple halo nevi in siblings. (5835331)
1965

Variations for Halo Nevi

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Expression for genes affiliated with Halo Nevi

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Halo Nevi

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Pathways for genes affiliated with Halo Nevi

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Sources:
51PathCards, 54QIAGEN, 56Reactome, 31KEGG, 61Thomson Reuters
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Pathways related to Halo Nevi according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5HLA-DRB1, HLA-DRB4
2
Show member pathways
9.5HLA-DRB1, HLA-DRB4
39.5HLA-DRB4, HLA-DRB1
4
Show member pathways
Immune response T cell receptor signaling pathway61
Immune response CD28 signaling61
Immune response ICOS pathway in T helper cell61
9.5HLA-DRB1, HLA-DRB4
59.5HLA-DRB1, HLA-DRB4
69.5HLA-DRB4, HLA-DRB1
7
Show member pathways
Immune response IL 22 signaling pathway61
G protein signaling N RAS regulation pathway61
9.5HLA-DRB1, HLA-DRB4
89.5HLA-DRB1, HLA-DRB4
9
Show member pathways
9.5HLA-DRB1, HLA-DRB4
109.5HLA-DRB4, HLA-DRB1
119.5HLA-DRB1, HLA-DRB4
12
Show member pathways
9.5HLA-DRB1, HLA-DRB4

Compounds for genes affiliated with Halo Nevi

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Sources:
30IUPHAR, 25HMDB, 46Novoseek
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Compounds related to Halo Nevi according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1l-dopa30 2510.6SLC3A2, TYR
2dopachrome469.3PMEL, TYR
3hemocyanin469.2PMEL, TYR
4alanine469.0SLC3A2, HLA-DRB1, TYR
5arginine468.9TYR, HLA-DRB1, SLC3A2
6glutamate468.7SLC3A2, HLA-DRB1, TYR

GO Terms for genes affiliated with Halo Nevi

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17Gene Ontology
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Cellular components related to Halo Nevi according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.7HLA-DRB4, HLA-DRB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:0715569.7HLA-DRB1, HLA-DRB4
3clathrin-coated endocytic vesicle membraneGO:0306699.7HLA-DRB1, HLA-DRB4
4transport vesicle membraneGO:0306589.6HLA-DRB4, HLA-DRB1
5ER to Golgi transport vesicle membraneGO:0125079.5HLA-DRB1, HLA-DRB4
6late endosome membraneGO:0319029.5HLA-DRB1, HLA-DRB4
7trans-Golgi network membraneGO:0325889.4HLA-DRB1, HLA-DRB4
8endocytic vesicle membraneGO:0306669.2HLA-DRB1, HLA-DRB4
9melanosomeGO:0424708.3SLC3A2, PMEL, TYR, MLANA

Biological processes related to Halo Nevi according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1regulation of interleukin-4 productionGO:0326739.8HLA-DRB1, HLA-DRB4
2regulation of interleukin-10 secretionGO:20011799.8HLA-DRB1, HLA-DRB4
3immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.8HLA-DRB1, HLA-DRB4
4humoral immune response mediated by circulating immunoglobulinGO:0024559.8HLA-DRB4, HLA-DRB1
5T-helper 1 type immune responseGO:0420889.8HLA-DRB1, HLA-DRB4
6inflammatory response to antigenic stimulusGO:0024379.8HLA-DRB1, HLA-DRB4
7detection of bacteriumGO:0160459.7HLA-DRB1, HLA-DRB4
8positive regulation of insulin secretion involved in cellular response to glucose stimulusGO:0357749.7HLA-DRB4, HLA-DRB1
9negative regulation of interferon-gamma productionGO:0326899.7HLA-DRB1, HLA-DRB4
10negative regulation of T cell proliferationGO:0421309.7HLA-DRB1, HLA-DRB4
11protein tetramerizationGO:0512629.6HLA-DRB1, HLA-DRB4
12interferon-gamma-mediated signaling pathwayGO:0603339.5HLA-DRB4, HLA-DRB1
13antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198869.5HLA-DRB1, HLA-DRB4
14T cell costimulationGO:0312959.4HLA-DRB1, HLA-DRB4
15T cell receptor signaling pathwayGO:0508529.2HLA-DRB1, HLA-DRB4

Molecular functions related to Halo Nevi according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:0426059.5HLA-DRB1, HLA-DRB4
2MHC class II receptor activityGO:0323959.2HLA-DRB1, HLA-DRB4

Products for genes affiliated with Halo Nevi

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Halo Nevi

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet