MCID: HLN001
MIFTS: 33

Halo Nevi

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Halo Nevi

MalaCards integrated aliases for Halo Nevi:

Name: Halo Nevi 53 49
Leukoderma Acquisitum Centrifugum of Sutton 53 49
Halo Nevus 69

Classifications:



External Ids:

OMIM 53 234300
MedGen 39 C0474824
UMLS 69 C0474824

Summaries for Halo Nevi

MalaCards based summary : Halo Nevi, also known as leukoderma acquisitum centrifugum of sutton, is related to vitiligo-associated multiple autoimmune disease susceptibility 1 and melanoma, uveal. An important gene associated with Halo Nevi is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Translocation of ZAP-70 to Immunological synapse and MHC class II antigen presentation. Affiliated tissues include t cells, skin and lung, and related phenotype is pigmentation.

Wikipedia : 72 Halo nevus (also known as \"Leukoderma acquisitum centrifugum,\" \"Perinevoid vitiligo,\" and \"Sutton... more...

Description from OMIM: 234300

Related Diseases for Halo Nevi

Graphical network of the top 20 diseases related to Halo Nevi:



Diseases related to Halo Nevi

Symptoms & Phenotypes for Halo Nevi

Clinical features from OMIM:

234300

MGI Mouse Phenotypes related to Halo Nevi:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 pigmentation MP:0001186 8.8 MLANA PMEL TYR

Drugs & Therapeutics for Halo Nevi

Search Clinical Trials , NIH Clinical Center for Halo Nevi

Genetic Tests for Halo Nevi

Anatomical Context for Halo Nevi

MalaCards organs/tissues related to Halo Nevi:

38
T Cells, Skin, Lung

Publications for Halo Nevi

Articles related to Halo Nevi:

(show all 42)
# Title Authors Year
1
Development of Halo Nevi in a Lung Cancer Patient: A Novel Immune-Related Cutaneous Event from Atezolizumab. ( 29036261 )
2017
2
Differences in the melanosome distribution within the epidermal melanin units and its association with the impairing background of leukoderma in vitiligo and halo nevi: a retrospective study. ( 28314912 )
2017
3
Alopecia, halo nevi and vitiligo in a pediatric case of Turner's syndrome. ( 27238352 )
2016
4
Multiple halo nevi subsequent to a short period of sunbathing. ( 25703501 )
2015
5
A comparative study of mitochondrial ultrastructure in melanocytes from perilesional vitiligo skin and perilesional halo nevi skin. ( 25672813 )
2015
6
Comparison of Childhood Vitiligo Presenting with or without Associated Halo Nevi. ( 26573093 )
2015
7
Spontaneous partial repigmentation of halo nevi around congenital melanocytic nevus and vitiligo in a 13-year-old boy. ( 24448132 )
2014
8
Study of the Immunophenotype of the Inflammatory Cells in Melanomas With Regression and Halo Nevi. ( 25222195 )
2014
9
Halo nevi associated with interferon beta-1a therapy. ( 22445564 )
2012
10
The natural history of halo nevi: a retrospective case series. ( 22387032 )
2012
11
Foxp3(+) regulatory T cells are increased in the early stages of halo nevi: clinicopathological features of 30 halo nevi. ( 23006793 )
2012
12
Halo nevi association in nonsegmental vitiligo affects age at onset and depigmentation pattern. ( 22508876 )
2012
13
Cutaneous halo nevi following plaque radiotherapy for uveal melanoma. ( 22084224 )
2011
14
Halo nevi related to treatment with imatinib in a dermatofibrosarcoma protuberans patient. ( 19694892 )
2010
15
Long term results of non cultured epidermal cellular grafting in vitiligo, halo nevi, piebaldism and nevus depigmentosus. ( 20560951 )
2010
16
First histopathological and immunophenotypic analysis of early dynamic events in a patient with segmental vitiligo associated with halo nevi. ( 20370855 )
2010
17
Halo nevi in Turner syndrome. ( 20653854 )
2010
18
Worsening alopecia areata and de novo occurrence of multiple halo nevi in a patient receiving infliximab. ( 18216487 )
2008
19
Dermoscopy patterns of halo nevi. ( 17178990 )
2006
20
Typical halo nevi in childhood: is a biopsy necessary? Yes, but perhaps from the duodenum! ( 16227050 )
2005
21
Difference in pathogenesis between vitiligo vulgaris and halo nevi associated with vitiligo is supported by an HLA association study. ( 15140072 )
2004
22
Unusual halo nevi--darkening rather than lightening of the central nevus. ( 11455145 )
2001
23
Typical halo nevi in childhood: is a biopsy necessary? ( 11174633 )
2001
24
Presence of activated lymphocytes in the peripheral blood of patients with halo nevi. ( 10495377 )
1999
25
Immune-mediated destruction of melanocytes in halo nevi is associated with the local expansion of a limited number of T cell clones. ( 9973443 )
1999
26
The immune response in halo nevi. ( 9344203 )
1997
27
Characterization of the mononuclear infiltrate involved in regression of halo nevi. ( 7798386 )
1994
28
Analysis of major histocompatibility antigens and the mononuclear cell infiltrate in halo nevi. ( 3159801 )
1985
29
Halo nevi and melanoma. ( 6464957 )
1984
30
Vitiligo or halo nevi occurring in two patients with choroidal melanoma. ( 7059198 )
1982
31
Comparison of cell-mediated immunity to melanoma cells in patients with vitiligo, halo nevi or melanoma. ( 7410884 )
1980
32
Halo nevi and the Vogt-Koyanagi-Harada syndrome. Manifestations of vitiligo. ( 7377805 )
1980
33
Halo nevi without dermal infiltrate. ( 718234 )
1978
34
Letter: Halo nevi of scalp with poliosis. ( 1267471 )
1976
35
Letter: Malignant melanoma arising with two halo nevi. ( 1259452 )
1976
36
Ultrastructure of halo nevi. ( 1228211 )
1975
37
Ultrastructural changes of mitochondria in pigmented and halo nevi. ( 4458608 )
1974
38
Halo nevi and melanoma. ( 4741011 )
1973
39
Multiple halo nevi. Histopathological findings in a 14-year-old boy. ( 5763200 )
1969
40
Halo nevi. ( 5659416 )
1968
41
Ultrastructure of halo nevi. ( 5659050 )
1968
42
Multiple halo nevi in siblings. ( 5835331 )
1965

Variations for Halo Nevi

Expression for Halo Nevi

Search GEO for disease gene expression data for Halo Nevi.

Pathways for Halo Nevi

GO Terms for Halo Nevi

Cellular components related to Halo Nevi according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 late endosome membrane GO:0031902 9.46 HLA-DRB1 HLA-DRB4
2 trans-Golgi network membrane GO:0032588 9.43 HLA-DRB1 HLA-DRB4
3 endocytic vesicle membrane GO:0030666 9.4 HLA-DRB1 HLA-DRB4
4 ER to Golgi transport vesicle membrane GO:0012507 9.37 HLA-DRB1 HLA-DRB4
5 transport vesicle membrane GO:0030658 9.32 HLA-DRB1 HLA-DRB4
6 clathrin-coated endocytic vesicle membrane GO:0030669 9.26 HLA-DRB1 HLA-DRB4
7 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.16 HLA-DRB1 HLA-DRB4
8 MHC class II protein complex GO:0042613 8.96 HLA-DRB1 HLA-DRB4
9 melanosome GO:0042470 8.92 MLANA PMEL SLC3A2 TYR

Biological processes related to Halo Nevi according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.26 HLA-DRB1 HLA-DRB4
2 T cell costimulation GO:0031295 9.16 HLA-DRB1 HLA-DRB4
3 interferon-gamma-mediated signaling pathway GO:0060333 8.96 HLA-DRB1 HLA-DRB4
4 melanin biosynthetic process GO:0042438 8.62 PMEL TYR

Sources for Halo Nevi

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....