MCID: HLN001
MIFTS: 28

Halo Nevi malady

Rare diseases, Skin diseases categories

Aliases & Classifications for Halo Nevi

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Halo Nevi, Aliases & Descriptions:

Name: Halo Nevi 41
Leukoderma Acquisitum Centrifugum of Sutton 41
 
Halo Nevus 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases


Summaries for Halo Nevi

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MalaCards based summary: Halo Nevi, also known as leukoderma acquisitum centrifugum of sutton, is related to melanoma and uveal melanoma. An important gene associated with Halo Nevi is HLA-DRB4 (major histocompatibility complex, class II, DR beta 4), and among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CD28 co-stimulation. The compounds l-dopa and dopachrome have been mentioned in the context of this disorder. Affiliated tissues include t cells and skin, and related mouse phenotype pigmentation.

Related Diseases for Halo Nevi

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Graphical network of diseases related to Halo Nevi:



Diseases related to halo nevi

Symptoms for Halo Nevi

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Drugs & Therapeutics for Halo Nevi

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Drug clinical trials:

Search ClinicalTrials for Halo Nevi

Search NIH Clinical Center for Halo Nevi

Genetic Tests for Halo Nevi

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Anatomical Context for Halo Nevi

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MalaCards organs/tissues related to Halo Nevi:

31
T cells, Skin

Animal Models for Halo Nevi or affiliated genes

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MGI Mouse Phenotypes related to Halo Nevi:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.6PMEL, TYR, MLANA

Publications for Halo Nevi

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Articles related to Halo Nevi:

(show all 38)
idTitleAuthorsYear
1
Multiple halo nevi subsequent to a short period of sunbathing. (25703501)
2015
2
A comparative study of mitochondrial ultrastructure in melanocytes from perilesional vitiligo skin and perilesional halo nevi skin. (25672813)
2015
3
Study of the Immunophenotype of the Inflammatory Cells in Melanomas With Regression and Halo Nevi. (25222195)
2014
4
Spontaneous partial repigmentation of halo nevi around congenital melanocytic nevus and vitiligo in a 13-year-old boy. (24448132)
2014
5
The natural history of halo nevi: a retrospective case series. (22387032)
2012
6
Halo nevi associated with interferon beta-1a therapy. (22445564)
2012
7
Halo nevi association in nonsegmental vitiligo affects age at onset and depigmentation pattern. (22508876)
2012
8
Foxp3(+) regulatory T cells are increased in the early stages of halo nevi: clinicopathological features of 30 halo nevi. (23006793)
2012
9
Cutaneous halo nevi following plaque radiotherapy for uveal melanoma. (22084224)
2011
10
Long term results of non cultured epidermal cellular grafting in vitiligo, halo nevi, piebaldism and nevus depigmentosus. (20560951)
2010
11
First histopathological and immunophenotypic analysis of early dynamic events in a patient with segmental vitiligo associated with halo nevi. (20370855)
2010
12
Halo nevi in Turner syndrome. (20653854)
2010
13
Halo nevi related to treatment with imatinib in a dermatofibrosarcoma protuberans patient. (19694892)
2010
14
Worsening alopecia areata and de novo occurrence of multiple halo nevi in a patient receiving infliximab. (18216487)
2008
15
Dermoscopy patterns of halo nevi. (17178990)
2006
16
Typical halo nevi in childhood: is a biopsy necessary? Yes, but perhaps from the duodenum! (16227050)
2005
17
Difference in pathogenesis between vitiligo vulgaris and halo nevi associated with vitiligo is supported by an HLA association study. (15140072)
2004
18
Typical halo nevi in childhood: is a biopsy necessary? (11174633)
2001
19
Unusual halo nevi--darkening rather than lightening of the central nevus. (11455145)
2001
20
Immune-mediated destruction of melanocytes in halo nevi is associated with the local expansion of a limited number of T cell clones. (9973443)
1999
21
Presence of activated lymphocytes in the peripheral blood of patients with halo nevi. (10495377)
1999
22
The immune response in halo nevi. (9344203)
1997
23
Characterization of the mononuclear infiltrate involved in regression of halo nevi. (7798386)
1994
24
Analysis of major histocompatibility antigens and the mononuclear cell infiltrate in halo nevi. (3159801)
1985
25
Halo nevi and melanoma. (6464957)
1984
26
Vitiligo or halo nevi occurring in two patients with choroidal melanoma. (7059198)
1982
27
Comparison of cell-mediated immunity to melanoma cells in patients with vitiligo, halo nevi or melanoma. (7410884)
1980
28
Halo nevi and the Vogt-Koyanagi-Harada syndrome. Manifestations of vitiligo. (7377805)
1980
29
Halo nevi without dermal infiltrate. (718234)
1978
30
Letter: Malignant melanoma arising with two halo nevi. (1259452)
1976
31
Letter: Halo nevi of scalp with poliosis. (1267471)
1976
32
Ultrastructure of halo nevi. (1228211)
1975
33
Ultrastructural changes of mitochondria in pigmented and halo nevi. (4458608)
1974
34
Halo nevi and melanoma. (4741011)
1973
35
Multiple halo nevi. Histopathological findings in a 14-year-old boy. (5763200)
1969
36
Ultrastructure of halo nevi. (5659050)
1968
37
Halo nevi. (5659416)
1968
38
Multiple halo nevi in siblings. (5835331)
1965

Variations for Halo Nevi

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Expression for genes affiliated with Halo Nevi

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Search GEO for disease gene expression data for Halo Nevi.

Pathways for genes affiliated with Halo Nevi

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Pathways related to Halo Nevi according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5HLA-DRB1, HLA-DRB4
2
Show member pathways
9.5HLA-DRB1, HLA-DRB4
39.5HLA-DRB4, HLA-DRB1
4
Show member pathways
Immune response T cell receptor signaling pathway58
Immune response CD28 signaling58
Immune response ICOS pathway in T helper cell58
9.5HLA-DRB1, HLA-DRB4
59.5HLA-DRB1, HLA-DRB4
69.5HLA-DRB4, HLA-DRB1
7
Show member pathways
Immune response IL 22 signaling pathway58
G protein signaling N RAS regulation pathway58
9.5HLA-DRB1, HLA-DRB4
89.5HLA-DRB1, HLA-DRB4
9
Show member pathways
9.5HLA-DRB1, HLA-DRB4
109.5HLA-DRB4, HLA-DRB1
119.5HLA-DRB1, HLA-DRB4
12
Show member pathways
9.5HLA-DRB1, HLA-DRB4

Compounds for genes affiliated with Halo Nevi

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Sources:
28IUPHAR, 24HMDB, 43Novoseek
See all sources

Compounds related to Halo Nevi according to GeneCards Suite gene sharing:

idCompoundScoreTop Affiliating Genes
1l-dopa28 2410.6SLC3A2, TYR
2dopachrome439.3PMEL, TYR
3hemocyanin439.2PMEL, TYR
4alanine439.0SLC3A2, HLA-DRB1, TYR
5arginine438.9TYR, HLA-DRB1, SLC3A2
6glutamate438.7SLC3A2, HLA-DRB1, TYR

GO Terms for genes affiliated with Halo Nevi

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Cellular components related to Halo Nevi according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:00426139.7HLA-DRB4, HLA-DRB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:00715569.7HLA-DRB1, HLA-DRB4
3clathrin-coated endocytic vesicle membraneGO:00306699.7HLA-DRB1, HLA-DRB4
4transport vesicle membraneGO:00306589.6HLA-DRB4, HLA-DRB1
5ER to Golgi transport vesicle membraneGO:00125079.5HLA-DRB1, HLA-DRB4
6late endosome membraneGO:00319029.5HLA-DRB1, HLA-DRB4
7trans-Golgi network membraneGO:00325889.4HLA-DRB1, HLA-DRB4
8endocytic vesicle membraneGO:00306669.2HLA-DRB1, HLA-DRB4
9melanosomeGO:00424708.3SLC3A2, PMEL, TYR, MLANA

Biological processes related to Halo Nevi according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1regulation of interleukin-4 productionGO:00326739.8HLA-DRB1, HLA-DRB4
2regulation of interleukin-10 secretionGO:020011799.8HLA-DRB1, HLA-DRB4
3immunoglobulin production involved in immunoglobulin mediated immune responseGO:00023819.8HLA-DRB1, HLA-DRB4
4humoral immune response mediated by circulating immunoglobulinGO:00024559.8HLA-DRB4, HLA-DRB1
5T-helper 1 type immune responseGO:00420889.8HLA-DRB1, HLA-DRB4
6inflammatory response to antigenic stimulusGO:00024379.8HLA-DRB1, HLA-DRB4
7detection of bacteriumGO:00160459.7HLA-DRB1, HLA-DRB4
8positive regulation of insulin secretion involved in cellular response to glucose stimulusGO:00357749.7HLA-DRB4, HLA-DRB1
9negative regulation of interferon-gamma productionGO:00326899.7HLA-DRB1, HLA-DRB4
10negative regulation of T cell proliferationGO:00421309.7HLA-DRB1, HLA-DRB4
11protein tetramerizationGO:00512629.6HLA-DRB1, HLA-DRB4
12interferon-gamma-mediated signaling pathwayGO:00603339.5HLA-DRB4, HLA-DRB1
13antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198869.5HLA-DRB1, HLA-DRB4
14T cell costimulationGO:00312959.4HLA-DRB1, HLA-DRB4
15T cell receptor signaling pathwayGO:00508529.2HLA-DRB1, HLA-DRB4

Molecular functions related to Halo Nevi according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:00426059.5HLA-DRB1, HLA-DRB4
2MHC class II receptor activityGO:00323959.2HLA-DRB1, HLA-DRB4

Products for genes affiliated with Halo Nevi

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  • Antibodies
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Sources for Halo Nevi

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet