MCID: HLN001
MIFTS: 23

Halo Nevi malady

Summaries for Halo Nevi

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63Wikipedia, 32MalaCards
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Wikipedia:63 Halo nevus (also known as \"Leukoderma acquisitum centrifugum,\" \"Perinevoid vitiligo,\" and \"Sutton... more...

MalaCards: Halo Nevi, also known as leukoderma acquisitum centrifugum of sutton, is related to vitiligo and melanoma. An important gene associated with Halo Nevi is HLA-DRB4 (major histocompatibility complex, class II, DR beta 4), and among its related pathways are Rheumatoid arthritis and Immune response T cell receptor signaling pathway. The compounds hemocyanin and l-dopa have been mentioned in the context of this disorder. Related mouse phenotype pigmentation.

Aliases & Classifications for Halo Nevi

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42NIH Rare Diseases, 60UMLS
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Aliases & Descriptions:

halo nevi 42
leukoderma acquisitum centrifugum of sutton 42
halo nevus 60


Related Diseases for Halo Nevi

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Halo Nevi:



Diseases related to halo nevi

Clinical Features for Halo Nevi

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Drugs & Therapeutics for Halo Nevi

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Halo Nevi

Search CenterWatch for Halo Nevi

Genetic Tests for Halo Nevi

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Anatomical Context for Halo Nevi

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Animal Models for Halo Nevi or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Halo Nevi:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.6TYR, MLANA, PMEL

Publications for Halo Nevi

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Genetic Variations for Halo Nevi

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Expression for genes affiliated with Halo Nevi

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Halo Nevi

Search GEO for disease gene expression data for Halo Nevi.

Pathways for genes affiliated with Halo Nevi

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Sources:
29KEGG, 12EMD Millipore, 53Reactome, 51QIAGEN
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Compounds for genes affiliated with Halo Nevi

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Sources:
44Novoseek, 28IUPHAR, 24HMDB
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Compounds related to Halo Nevi according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1hemocyanin449.4TYR, PMEL
2l-dopa28 2410.2SLC3A2, TYR
3dopachrome449.1TYR, PMEL

GO Terms for genes affiliated with Halo Nevi

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Sources:
16Gene Ontology
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Cellular components related to Halo Nevi according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.8HLA-DRB1, HLA-DRB4
2clathrin-coated endocytic vesicle membraneGO:0306699.8HLA-DRB1, HLA-DRB4
3integral to lumenal side of endoplasmic reticulum membraneGO:0715569.7HLA-DRB1, HLA-DRB4
4ER to Golgi transport vesicle membraneGO:0125079.7HLA-DRB1, HLA-DRB4
5transport vesicle membraneGO:0306589.6HLA-DRB4, HLA-DRB1
6late endosome membraneGO:0319029.6HLA-DRB4, HLA-DRB1
7trans-Golgi network membraneGO:0325889.5HLA-DRB4, HLA-DRB1
8endocytic vesicle membraneGO:0306669.3HLA-DRB4, HLA-DRB1
9melanosomeGO:0424708.2SLC3A2, TYR, MLANA, PMEL

Biological processes related to Halo Nevi according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1regulation of interleukin-10 secretionGO:20011799.9HLA-DRB4, HLA-DRB1
2regulation of interleukin-4 productionGO:0326739.9HLA-DRB4, HLA-DRB1
3immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.9HLA-DRB1, HLA-DRB4
4humoral immune response mediated by circulating immunoglobulinGO:0024559.9HLA-DRB4, HLA-DRB1
5T-helper 1 type immune responseGO:0420889.9HLA-DRB4, HLA-DRB1
6inflammatory response to antigenic stimulusGO:0024379.8HLA-DRB1, HLA-DRB4
7positive regulation of insulin secretion involved in cellular response to glucose stimulusGO:0357749.8HLA-DRB4, HLA-DRB1
8detection of bacteriumGO:0160459.8HLA-DRB1, HLA-DRB4
9negative regulation of interferon-gamma productionGO:0326899.8HLA-DRB1, HLA-DRB4
10negative regulation of T cell proliferationGO:0421309.7HLA-DRB1, HLA-DRB4
11protein tetramerizationGO:0512629.7HLA-DRB1, HLA-DRB4
12interferon-gamma-mediated signaling pathwayGO:0603339.6HLA-DRB4, HLA-DRB1
13antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198869.6HLA-DRB4, HLA-DRB1
14T cell costimulationGO:0312959.5HLA-DRB4, HLA-DRB1
15T cell receptor signaling pathwayGO:0508529.3HLA-DRB1, HLA-DRB4

Molecular functions related to Halo Nevi according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:0426059.6HLA-DRB1, HLA-DRB4
2MHC class II receptor activityGO:0323959.3HLA-DRB1, HLA-DRB4

Products for genes affiliated with Halo Nevi

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Halo Nevi

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet