MCID: HLN001
MIFTS: 33

Halo Nevi malady

Rare diseases, Skin diseases categories
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Summaries for Halo Nevi

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Wikipedia:65 Halo nevus (also known as \"Leukoderma acquisitum centrifugum,\" \"Perinevoid vitiligo,\" and \"Sutton... more...

MalaCards based summary: Halo Nevi, also known as leukoderma acquisitum centrifugum of sutton, is related to vitiligo and melanoma. An important gene associated with Halo Nevi is HLA-DRB4 (major histocompatibility complex, class II, DR beta 4), and among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CD28 co-stimulation. The compounds l-dopa and dopachrome have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related mouse phenotype pigmentation.

Aliases & Classifications for Halo Nevi

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Halo Nevi, Aliases & Descriptions:

Name: Halo Nevi 42
Leukoderma Acquisitum Centrifugum of Sutton 42 62
 
Halo Nevus 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Skin diseases


Related Diseases for Halo Nevi

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Graphical network of diseases related to Halo Nevi:



Diseases related to halo nevi

Symptoms for Halo Nevi

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Drugs & Therapeutics for Halo Nevi

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Drug clinical trials:

Search ClinicalTrials for Halo Nevi

Search NIH Clinical Center for Halo Nevi

Genetic Tests for Halo Nevi

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Anatomical Context for Halo Nevi

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MalaCards organs/tissues related to Halo Nevi:

32
T cells

Animal Models for Halo Nevi or affiliated genes

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MGI Mouse Phenotypes related to Halo Nevi:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011868.6PMEL, TYR, MLANA

Publications for Halo Nevi

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Articles related to Halo Nevi:

(show all 36)
idTitleAuthorsYear
1
Study of the Immunophenotype of the Inflammatory Cells in Melanomas With Regression and Halo Nevi. (25222195)
2014
2
Spontaneous partial repigmentation of halo nevi around congenital melanocytic nevus and vitiligo in a 13-year-old boy. (24448132)
2014
3
The natural history of halo nevi: a retrospective case series. (22387032)
2012
4
Halo nevi associated with interferon beta-1a therapy. (22445564)
2012
5
Halo nevi association in nonsegmental vitiligo affects age at onset and depigmentation pattern. (22508876)
2012
6
Foxp3(+) regulatory T cells are increased in the early stages of halo nevi: clinicopathological features of 30 halo nevi. (23006793)
2012
7
Cutaneous halo nevi following plaque radiotherapy for uveal melanoma. (22084224)
2011
8
Long term results of non cultured epidermal cellular grafting in vitiligo, halo nevi, piebaldism and nevus depigmentosus. (20560951)
2010
9
First histopathological and immunophenotypic analysis of early dynamic events in a patient with segmental vitiligo associated with halo nevi. (20370855)
2010
10
Halo nevi in Turner syndrome. (20653854)
2010
11
Halo nevi related to treatment with imatinib in a dermatofibrosarcoma protuberans patient. (19694892)
2010
12
Worsening alopecia areata and de novo occurrence of multiple halo nevi in a patient receiving infliximab. (18216487)
2008
13
Dermoscopy patterns of halo nevi. (17178990)
2006
14
Typical halo nevi in childhood: is a biopsy necessary? Yes, but perhaps from the duodenum! (16227050)
2005
15
Difference in pathogenesis between vitiligo vulgaris and halo nevi associated with vitiligo is supported by an HLA association study. (15140072)
2004
16
Typical halo nevi in childhood: is a biopsy necessary? (11174633)
2001
17
Unusual halo nevi--darkening rather than lightening of the central nevus. (11455145)
2001
18
Immune-mediated destruction of melanocytes in halo nevi is associated with the local expansion of a limited number of T cell clones. (9973443)
1999
19
Presence of activated lymphocytes in the peripheral blood of patients with halo nevi. (10495377)
1999
20
The immune response in halo nevi. (9344203)
1997
21
Characterization of the mononuclear infiltrate involved in regression of halo nevi. (7798386)
1994
22
Analysis of major histocompatibility antigens and the mononuclear cell infiltrate in halo nevi. (3159801)
1985
23
Halo nevi and melanoma. (6464957)
1984
24
Vitiligo or halo nevi occurring in two patients with choroidal melanoma. (7059198)
1982
25
Comparison of cell-mediated immunity to melanoma cells in patients with vitiligo, halo nevi or melanoma. (7410884)
1980
26
Halo nevi and the Vogt-Koyanagi-Harada syndrome. Manifestations of vitiligo. (7377805)
1980
27
Halo nevi without dermal infiltrate. (718234)
1978
28
Letter: Malignant melanoma arising with two halo nevi. (1259452)
1976
29
Letter: Halo nevi of scalp with poliosis. (1267471)
1976
30
Ultrastructure of halo nevi. (1228211)
1975
31
Ultrastructural changes of mitochondria in pigmented and halo nevi. (4458608)
1974
32
Halo nevi and melanoma. (4741011)
1973
33
Multiple halo nevi. Histopathological findings in a 14-year-old boy. (5763200)
1969
34
Ultrastructure of halo nevi. (5659050)
1968
35
Halo nevi. (5659416)
1968
36
Multiple halo nevi in siblings. (5835331)
1965

Variations for Halo Nevi

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Expression for genes affiliated with Halo Nevi

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Expression patterns in normal tissues for genes affiliated with Halo Nevi

Search GEO for disease gene expression data for Halo Nevi.

Pathways for genes affiliated with Halo Nevi

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Pathways related to Halo Nevi according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5HLA-DRB1, HLA-DRB4
2
Show member pathways
9.5HLA-DRB1, HLA-DRB4
39.5HLA-DRB4, HLA-DRB1
4
Show member pathways
Immune response T cell receptor signaling pathway60
Immune response CD28 signaling60
Immune response ICOS pathway in T helper cell60
9.5HLA-DRB1, HLA-DRB4
59.5HLA-DRB1, HLA-DRB4
69.5HLA-DRB4, HLA-DRB1
7
Show member pathways
Immune response IL 22 signaling pathway60
G protein signaling N RAS regulation pathway60
9.5HLA-DRB1, HLA-DRB4
89.5HLA-DRB1, HLA-DRB4
9
Show member pathways
9.5HLA-DRB1, HLA-DRB4
109.5HLA-DRB4, HLA-DRB1
119.5HLA-DRB1, HLA-DRB4
12
Show member pathways
9.5HLA-DRB1, HLA-DRB4

Compounds for genes affiliated with Halo Nevi

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Sources:
28IUPHAR, 24HMDB, 44Novoseek
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Compounds related to Halo Nevi according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1l-dopa28 2410.6SLC3A2, TYR
2dopachrome449.3PMEL, TYR
3hemocyanin449.2PMEL, TYR
4alanine449.0SLC3A2, HLA-DRB1, TYR
5arginine448.9TYR, HLA-DRB1, SLC3A2
6glutamate448.7SLC3A2, HLA-DRB1, TYR

GO Terms for genes affiliated with Halo Nevi

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Cellular components related to Halo Nevi according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class II protein complexGO:0426139.7HLA-DRB4, HLA-DRB1
2integral component of lumenal side of endoplasmic reticulum membraneGO:0715569.7HLA-DRB1, HLA-DRB4
3clathrin-coated endocytic vesicle membraneGO:0306699.7HLA-DRB1, HLA-DRB4
4transport vesicle membraneGO:0306589.6HLA-DRB4, HLA-DRB1
5ER to Golgi transport vesicle membraneGO:0125079.5HLA-DRB1, HLA-DRB4
6late endosome membraneGO:0319029.5HLA-DRB1, HLA-DRB4
7trans-Golgi network membraneGO:0325889.4HLA-DRB1, HLA-DRB4
8endocytic vesicle membraneGO:0306669.2HLA-DRB1, HLA-DRB4
9melanosomeGO:0424708.3SLC3A2, PMEL, TYR, MLANA

Biological processes related to Halo Nevi according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1regulation of interleukin-4 productionGO:0326739.8HLA-DRB1, HLA-DRB4
2regulation of interleukin-10 secretionGO:20011799.8HLA-DRB1, HLA-DRB4
3immunoglobulin production involved in immunoglobulin mediated immune responseGO:0023819.8HLA-DRB1, HLA-DRB4
4humoral immune response mediated by circulating immunoglobulinGO:0024559.8HLA-DRB4, HLA-DRB1
5T-helper 1 type immune responseGO:0420889.8HLA-DRB1, HLA-DRB4
6inflammatory response to antigenic stimulusGO:0024379.8HLA-DRB1, HLA-DRB4
7detection of bacteriumGO:0160459.7HLA-DRB1, HLA-DRB4
8positive regulation of insulin secretion involved in cellular response to glucose stimulusGO:0357749.7HLA-DRB4, HLA-DRB1
9negative regulation of interferon-gamma productionGO:0326899.7HLA-DRB1, HLA-DRB4
10negative regulation of T cell proliferationGO:0421309.7HLA-DRB1, HLA-DRB4
11protein tetramerizationGO:0512629.6HLA-DRB1, HLA-DRB4
12interferon-gamma-mediated signaling pathwayGO:0603339.5HLA-DRB4, HLA-DRB1
13antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198869.5HLA-DRB1, HLA-DRB4
14T cell costimulationGO:0312959.4HLA-DRB1, HLA-DRB4
15T cell receptor signaling pathwayGO:0508529.2HLA-DRB1, HLA-DRB4

Molecular functions related to Halo Nevi according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1peptide antigen bindingGO:0426059.5HLA-DRB1, HLA-DRB4
2MHC class II receptor activityGO:0323959.2HLA-DRB1, HLA-DRB4

Products for genes affiliated with Halo Nevi

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  • Antibodies
  • Proteins
  • Lysates

Sources for Halo Nevi

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet