Aliases & Classifications for Halothane Hepatitis

MalaCards integrated aliases for Halothane Hepatitis:

Name: Halothane Hepatitis 53 69
Hepatitis Halothane 51

Characteristics:

OMIM:

53
Inheritance:
autosomal recessive vs. multifactorial


External Ids:

OMIM 53 234350
MedGen 39 C0241913
UMLS 69 C0241913

Summaries for Halothane Hepatitis

MalaCards based summary : Halothane Hepatitis, also known as hepatitis halothane, is related to hepatitis and drug-induced hepatitis, and has symptoms including fever, obesity and hepatitis. An important gene associated with Halothane Hepatitis is UBE2B (Ubiquitin Conjugating Enzyme E2 B), and among its related pathways/superpathways are superpathway of tryptophan utilization and Protein processing in endoplasmic reticulum. Affiliated tissues include liver.

Description from OMIM: 234350

Related Diseases for Halothane Hepatitis

Graphical network of the top 20 diseases related to Halothane Hepatitis:



Diseases related to Halothane Hepatitis

Symptoms & Phenotypes for Halothane Hepatitis

Symptoms via clinical synopsis from OMIM:

53
Liver:
hepatitis after halothane anesthesia

Heme:
eosinophilia

Misc:
greater incidence in women
greater incidence in obesity
higher mortality than in viral hepatitis
onset earlier after multiple exposure
fever

Skin:
jaundice


Clinical features from OMIM:

234350

Human phenotypes related to Halothane Hepatitis:

31
# Description HPO Frequency HPO Source Accession
1 fever 31 HP:0001945
2 obesity 31 HP:0001513
3 hepatitis 31 HP:0012115
4 jaundice 31 HP:0000952
5 eosinophilia 31 HP:0001880

Drugs & Therapeutics for Halothane Hepatitis

Search Clinical Trials , NIH Clinical Center for Halothane Hepatitis

Genetic Tests for Halothane Hepatitis

Anatomical Context for Halothane Hepatitis

MalaCards organs/tissues related to Halothane Hepatitis:

38
Liver

Publications for Halothane Hepatitis

Articles related to Halothane Hepatitis:

(show all 21)
# Title Authors Year
1
Natural killer cells mediate severe liver injury in a murine model of halothane hepatitis. ( 21245496 )
2011
2
A mouse model of severe halothane hepatitis based on human risk factors. ( 20124411 )
2010
3
Halothane hepatitis in Iran: a review of 59 cases. ( 18785286 )
2008
4
Molecular basis of halothane hepatitis. ( 9442277 )
1998
5
Interindividual variability in P450-dependent generation of neoantigens in halothane hepatitis. ( 9877205 )
1998
6
Halothane hepatitis. ( 9744689 )
1998
7
Halothane hepatitis in a South African population--frequency and the influence of gender and ethnicity. ( 9259724 )
1997
8
Human cytochrome P450 2E1 is a major autoantigen associated with halothane hepatitis. ( 8902272 )
1996
9
Cytochrome P450 2E1 is a cell surface autoantigen in halothane hepatitis. ( 8794896 )
1996
10
Identification of the enzyme responsible for oxidative halothane metabolism: implications for prevention of halothane hepatitis. ( 8637342 )
1996
11
The lipoic acid containing components of the 2-oxoacid dehydrogenase complexes mimic trifluoroacetylated proteins and are autoantigens associated with halothane hepatitis. ( 7548757 )
1995
12
Suspected isoflurane hepatitis in an obese patient with a history of halothane hepatitis. ( 8533932 )
1995
13
Processing of endoplasmic reticulum luminal antigens associated with halothane hepatitis in rat hepatocytes. ( 7657302 )
1995
14
Molecular mimicry in halothane hepatitis: biochemical and structural characterization of lipoylated autoantigens. ( 7716787 )
1995
15
Hypothesis: halothane hepatitis--has thymol been overlooked? ( 8546308 )
1995
16
Sera from patients with halothane hepatitis contain antibodies to halothane-induced liver antigens which are not detectable by immunoblotting. ( 7932186 )
1994
17
Identification of the dihydrolipoamide acetyltransferase subunit of the human pyruvate dehydrogenase complex as an autoantigen in halothane hepatitis. Molecular mimicry of trifluoroacetyl-lysine by lipoic acid. ( 7519986 )
1994
18
A model for fatal halothane hepatitis in the guinea pig. ( 8053598 )
1994
19
Association of anti-58 kDa endoplasmic reticulum antibodies with halothane hepatitis. ( 8216376 )
1993
20
Autoantibodies to hepatic microsomal carboxylesterase in halothane hepatitis. ( 8105217 )
1993
21
Halothane hepatitis patients have serum antibodies that react with protein disulfide isomerase. ( 8406360 )
1993

Variations for Halothane Hepatitis

Expression for Halothane Hepatitis

Search GEO for disease gene expression data for Halothane Hepatitis.

Pathways for Halothane Hepatitis

Pathways related to Halothane Hepatitis according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.91 CYP2A6 CYP2E1 OGDH
2 11.85 CALR HSPA5 P4HB
3
Show member pathways
11.28 CYP2A6 CYP2C9 CYP2E1
4
Show member pathways
11.18 CYP2A6 CYP2C9 CYP2E1
5
Show member pathways
11.17 DLAT OGDH
6 11.09 CYP2C9 CYP2E1
7 11.04 CYP2A6 CYP2C9
8 10.99 CALR HSPA5
9
Show member pathways
10.94 CYP2C9 CYP2E1
10 10.88 CALR HSPA5
11 10.76 CYP2A6 CYP2C9
12
Show member pathways
10.75 CYP2A6 CYP2C9 CYP2E1
13 10.52 CYP2A6 CYP2C9
14 10.51 CYP2A6 CYP2C9 CYP2E1
15
Show member pathways
10.41 CYP2A6 CYP2E1
16 10.1 CYP2A6 CYP2C9 CYP2E1

GO Terms for Halothane Hepatitis

Cellular components related to Halothane Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular membrane-bounded organelle GO:0043231 9.67 CALR CYP2A6 CYP2C9 CYP2E1
2 endoplasmic reticulum GO:0005783 9.63 CALR CYP2A6 CYP2C9 CYP2E1 HSPA5 P4HB
3 endoplasmic reticulum lumen GO:0005788 9.5 CALR HSPA5 P4HB
4 smooth endoplasmic reticulum GO:0005790 9.26 CALR HSPA5
5 organelle membrane GO:0031090 9.13 CYP2A6 CYP2C9 CYP2E1
6 endoplasmic reticulum chaperone complex GO:0034663 8.62 HSPA5 P4HB

Biological processes related to Halothane Hepatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.72 CYP2A6 CYP2C9 CYP2E1 OGDH P4HB
2 steroid metabolic process GO:0008202 9.58 CYP2A6 CYP2C9 CYP2E1
3 tricarboxylic acid cycle GO:0006099 9.48 DLAT OGDH
4 cellular nitrogen compound metabolic process GO:0034641 9.46 DLAT OGDH
5 protein folding in endoplasmic reticulum GO:0034975 9.43 CALR HSPA5
6 exogenous drug catabolic process GO:0042738 9.37 CYP2A6 CYP2C9
7 ATF6-mediated unfolded protein response GO:0036500 9.26 CALR HSPA5
8 monoterpenoid metabolic process GO:0016098 9.16 CYP2C9 CYP2E1
9 drug metabolic process GO:0017144 9.13 CYP2A6 CYP2C9 CYP2E1
10 epoxygenase P450 pathway GO:0019373 8.8 CYP2A6 CYP2C9 CYP2E1

Molecular functions related to Halothane Hepatitis according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 9.76 CYP2A6 CYP2C9 CYP2E1 OGDH
2 ubiquitin protein ligase binding GO:0031625 9.69 CALR HSPA5 UBE2B
3 enzyme binding GO:0019899 9.67 CYP2A6 CYP2E1 HSPA5 P4HB
4 heme binding GO:0020037 9.58 CYP2A6 CYP2C9 CYP2E1
5 chaperone binding GO:0051087 9.5 CALR HSPA5 OGDH
6 monooxygenase activity GO:0004497 9.49 CYP2C9 CYP2E1
7 oxygen binding GO:0019825 9.48 CYP2C9 CYP2E1
8 iron ion binding GO:0005506 9.46 CALR CYP2A6 CYP2C9 CYP2E1
9 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.43 CYP2A6 CYP2E1
10 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.43 CYP2A6 CYP2C9 CYP2E1
11 steroid hydroxylase activity GO:0008395 9.13 CYP2A6 CYP2C9 CYP2E1
12 arachidonic acid epoxygenase activity GO:0008392 8.8 CYP2A6 CYP2C9 CYP2E1

Sources for Halothane Hepatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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