MCID: HND002
MIFTS: 42

Hand, Foot and Mouth Disease

Categories: Skin diseases, Infectious diseases

Aliases & Classifications for Hand, Foot and Mouth Disease

MalaCards integrated aliases for Hand, Foot and Mouth Disease:

Name: Hand, Foot and Mouth Disease 12 42 14
Vesicular Stomatitis and Exanthem 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10881
ICD10 33 B08.4
ICD9CM 35 074.3
MeSH 42 D006232
UMLS 69 C0018572

Summaries for Hand, Foot and Mouth Disease

Disease Ontology : 12 A viral infectious disease that results_in infection located in skin, has material basis in Human coxsackievirus A16 or has material basis in Human enterovirus 71, which are transmitted_by contaminated fomites, and transmitted_by contact with nose and throat secretions, saliva, blister fluid and stool of infected persons. The infection has symptom fever, has symptom poor appetite, has symptom malaise, has symptom sore throat, has symptom painful sores in the mouth, and has symptom skin rash on the palms of the hands and soles of the feet.

MalaCards based summary : Hand, Foot and Mouth Disease, also known as vesicular stomatitis and exanthem, is related to herpangina and mouth disease. An important gene associated with Hand, Foot and Mouth Disease is SCARB2 (Scavenger Receptor Class B Member 2), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. The drugs Mannitol and Ribavirin have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and testes.

CDC : 3 Hand, foot, and mouth disease is a common viral illness that usually affects infants and children younger than 5 years old. However, it can sometimes occur in older children and adults. Typical symptoms of hand, foot, and mouth disease include fever, mouth sores, and a skin rash.

Wikipedia : 72 Hand, foot, and mouth disease (HFMD) is a common infection caused by a group of viruses. It typically... more...

Related Diseases for Hand, Foot and Mouth Disease

Diseases related to Hand, Foot and Mouth Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 137)
id Related Disease Score Top Affiliating Genes
1 herpangina 25.2 C4A CA10 CA6 HMGB1 IFNG IL10
2 mouth disease 11.1
3 peroneal nerve paralysis 10.7 IL10 IL6
4 drug rash with eosinophilia and systemic symptoms 10.7 IL10 IL6
5 infancy electroclinical syndrome 10.6 IL10 IL6
6 ethmoid sinus adenocarcinoma 10.6 IL10 IL6
7 eye accommodation disease 10.6 IFNG IL10
8 graft-versus-host disease, protection against 10.6 IFNG IL10
9 thelaziasis 10.6 IFNG IL10
10 anencephaly and spina bifida x-linked 10.6 HMGB1 IL6
11 dumping syndrome 10.6 IFNG IL10
12 chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids 10.6 IFNG IL10
13 sternal cleft 10.6 HMGB1 IFNG
14 plantar wart 10.6 IFNG IL10
15 tricho onychic dysplasia 10.6 IL10 IL6
16 gerstmann syndrome 10.6 IFNG IL10
17 phlyctenulosis 10.5 IL10 IL6
18 centronuclear myopathy 5 10.5 IFNG IL10
19 strawberry gallbladder 10.5 IFNG IL10
20 oropharyngeal cancer, childhood 10.5 IFNG IL10
21 dementia pugilistica 10.5 IL6 NPPB
22 primary biliary cirrhosis 10.5 IL10 IL6
23 myofascial pain syndrome 10.5 IL10 IL6
24 tonsil cancer 10.5 IFNG IL10
25 chronic graft versus host disease 10.5 IFNG IL10
26 lymphocytic colitis 10.5 IFNG IL6
27 pasteurellosis 10.5 IFNG IL6
28 papillary squamous carcinoma 10.5 IFNG IL10
29 hemangioma of spleen 10.5 IFNG IL6
30 erythema multiforme 10.5 IL10 OAS1
31 spindle cell hemangioma 10.5 IFNG IL10
32 congenital nonspherocytic hemolytic anemia 10.5 IL6 NPPB
33 ulcerative colitis 10.5 IL10 IL6
34 tularemia 10.5 IFNG IL10
35 schwannoma of ureter 10.4 CA6 IL6
36 senile reticular retinal degeneration 10.4 IFNG IL10
37 distal monosomy 7q36 10.4 IFNG IL10
38 islet cell tumor 10.4 IL6 NPPB
39 psychologic dyspareunia 10.4 IFNG IL10
40 breast papillary carcinoma 10.4 IL10 IL6
41 placental abruption 10.4 IL6 NPPB
42 iida kannari syndrome 10.3 HMGB1 IL10 IL6
43 diffuse glomerulonephritis 10.3 IFNG IL6
44 multiple congenital anomalies mental retardation, growth failure and cleft lip palate 10.3 IFNG IL10 IL6
45 cyclosporiasis 10.3 IFNG IL10 IL6
46 early-onset zonular cataract 10.3 IFNG IL10 IL6
47 hepadnavirus infection 10.3 IFNG IL10 IL6
48 hemophagocytic lymphohistiocytosis 10.3 IFNG IL10 IL6
49 dysphagia 10.3 IFNG IL10 IL6
50 conduct disorder 10.3 IFNG IL10 IL6

Graphical network of the top 20 diseases related to Hand, Foot and Mouth Disease:



Diseases related to Hand, Foot and Mouth Disease

Symptoms & Phenotypes for Hand, Foot and Mouth Disease

Drugs & Therapeutics for Hand, Foot and Mouth Disease

Drugs for Hand, Foot and Mouth Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mannitol Approved, Investigational Phase 4 69-65-8 453 6251
2
Ribavirin Approved Phase 4 36791-04-5 37542
3 Antibodies Phase 4
4 Immunoglobulins Phase 4
5 Vaccines Phase 4,Phase 3,Phase 2,Phase 1
6 Anti-Infective Agents Phase 4
7 Antimetabolites Phase 4
8 Antiviral Agents Phase 4
9 Antibodies, Blocking Phase 4
10
Ibuprofen Approved Phase 2 15687-27-1 3672
11
Magnesium Sulfate Approved, Vet_approved Phase 2 7487-88-9 24083
12
Aluminum hydroxide Approved Phase 2,Phase 1 21645-51-2
13
Aluminum sulfate Approved Phase 2 10043-01-3
14
Acetaminophen Approved Phase 2 103-90-2 1983
15
Sucralfate Approved Phase 2 54182-58-0
16
Vitamin A Approved, Nutraceutical, Vet_approved Phase 2 11103-57-4, 68-26-8 445354
17 Pharmaceutical Solutions Phase 2
18 Analgesics Phase 2
19 Anesthetics Phase 2
20 Anti-Arrhythmia Agents Phase 2
21 Anticonvulsants Phase 2
22 calcium channel blockers Phase 2
23 Calcium, Dietary Phase 2
24 Central Nervous System Depressants Phase 2
25 Peripheral Nervous System Agents Phase 2
26 Retinol palmitate Phase 2
27 Tocolytic Agents Phase 2
28 Adjuvants, Immunologic Phase 2,Phase 1
29 Antacids Phase 2,Phase 1
30 Anti-Ulcer Agents Phase 2,Phase 1
31 Gastrointestinal Agents Phase 2,Phase 1
32 Anti-Inflammatory Agents Phase 2
33 Analgesics, Non-Narcotic Phase 2
34 Anti-Inflammatory Agents, Non-Steroidal Phase 2
35 Antipyretics Phase 2
36 Antirheumatic Agents Phase 2
37 Cyclooxygenase Inhibitors Phase 2
38 retinol Nutraceutical Phase 2
39
Methylprednisolone Approved, Vet_approved 83-43-2 6741
40
Prednisolone Approved, Vet_approved 50-24-8 5755
41
Vitamin C Approved, Nutraceutical 50-81-7 5785 54670067
42 Grape Approved, Nutraceutical
43 Anti-Bacterial Agents
44 Antibiotics, Antitubercular
45 Vitamins
46 Vitamin B Complex
47 Antiemetics
48 Antineoplastic Agents, Hormonal
49 Autonomic Agents
50 diuretics

Interventional clinical trials:

(show all 35)

id Name Status NCT ID Phase Drugs
1 Effect of Xiaoer Jiebiao Oral Liquid on Hand-foot-mouth Disease Recruiting NCT02328651 Phase 4 Ribavirin plus Xiao'er jiebiao oral liquid;Ribavirin
2 Phase IV Clinical Trial, Immunogenicity and Safety of EV71 Vaccine Recruiting NCT03278132 Phase 4
3 Safety and Immunogenicity of Concomitant Administration of EV71 Vaccine With EPI Vaccines Recruiting NCT03274102 Phase 4
4 The Phase IVb of Inactivated Enterovirus 71 Vaccine (Human Diploid Cell, KMB-17) in Chinese Children Active, not recruiting NCT03001986 Phase 4
5 The Phase IVc of Inactivated Enterovirus 71 Vaccine (Human Diploid Cell) Active, not recruiting NCT03240744 Phase 4
6 The Phase IVa of Inactivated Enterovirus 71 Vaccine (Human Diploid Cell, KMB-17) Active, not recruiting NCT02999828 Phase 4
7 The Phase IVd of Inactivated Enterovirus 71 Vaccine Enrolling by invitation NCT03296410 Phase 4
8 Safety, Three Batches Consistency and Immunity Duration of the Post-marketing Inactivated Enterovirus Type 71 (EV71) Vaccine in Children Aged 6-71 Months Not yet recruiting NCT02889497 Phase 4
9 An Efficacy Trial in Inactivated Enterovirus Type 71 (EV71) Vaccine Completed NCT01507857 Phase 3
10 Immunogenicity and Safety of Three Consecutive Lots of a New Inactivated Enterovirus Type 71 (EV71) Vaccine Completed NCT01636245 Phase 3
11 A Clinical Trial to Assess the Efficacy and Safety of an Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children Aged 6-35 Months Completed NCT01508247 Phase 3
12 A Protected Study of Inactivated EV71 Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants and Children Completed NCT01569581 Phase 3
13 Magnesium Sulphate for Severe Hand, Foot and Mouth Disease in Vietnam Completed NCT01940250 Phase 2 Magnesium Sulphate;Sterile water
14 A Phase II, Safety and Efficacy Study of Inactivated EV 71 Vaccine (Human Diploid Cell, KMB-17) in Chinese Infants Completed NCT01512706 Phase 2
15 A Study to Evaluate the Safety and Immunogenicity of EV71 Vaccine in Pediatric Subjects Aged 3 to 6 Years and 6 to 35 Months Old Completed NCT02777411 Phase 2
16 A Phase II Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants Completed NCT01399853 Phase 2
17 A Booster Dose of Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children Completed NCT01734408 Phase 2
18 A Study to Evaluate the Immunogenicity and Safety of EV71 Vaccine in Pediatric Subjects Aged 3 to 6 Years and 2 to 35 Months Old Active, not recruiting NCT03268083 Phase 2
19 Sucralfate to Improve Oral Intake in Children With Infectious Oral Ulcers: a Randomized, Double-blind, Placebo-Controlled Trial Not yet recruiting NCT03241030 Phase 2 Sucralfate;Acetaminophen;Ibuprofen
20 Safety and Immunogenicity Study of an Inactivated Vaccine Against Hand, Foot and Mouth Disease Caused by Enterovirus 71 Completed NCT01376479 Phase 1
21 A Safety Study of Inactivated EV71 Vaccine (Human Diploid Cell, KMB-17) in Chinese Adults, Children and Infants Completed NCT01391494 Phase 1
22 A Clinical Trial for Inactivated Vaccine(Vero Cell) Against EV71 in Chinese Healthy Young Adults and Children Completed NCT01267903 Phase 1
23 Safety of an Inactivated Enterovirus Type 71 Vaccines in Healthy Children Completed NCT01273246 Phase 1
24 A Clinical Trial for Inactivated Vaccine (Vero Cell) Against EV71 in Chinese Children and Infants Completed NCT01313715 Phase 1
25 A Multi-Center Clinical Trial To Evaluate Chinese Herbal Medicines in the Treatment of Severe Hand-foot-mouth Disease Unknown status NCT01145664 Herbal concentrate-granules plus western therapy;Reduning Injection plus western therapy;Western therapy
26 A Clinical Trial To Evaluate Reduning Injection in the Treatment of Mild Type of Hand, Foot, and Mouth Disease Unknown status NCT01175915
27 A Clinical Trial to Evaluate the Effectiveness and Safety of Xiyanping Injection in the Treatment of Mild Type of Hand, Foot, and Mouth Disease Unknown status NCT01182025 Xiyanping Injection;Xiyanping Injection with western medicine
28 Neurodevelopment Outcomes Following Severe Hand Foot and Mouth Disease in Vietnam Completed NCT02066714
29 A Follow-up Study for a Phase III, Efficacy Trial in Inactivated Enterovirus Type 71 (EV71) Vaccine Completed NCT02001233
30 Chinese Medicinal Treatment on Mild Hand, Foot, and Mouth Disease: Multicenter, Prospective, Randomized Double-blind, Placebo-controlled Study Completed NCT01769794 Western therapy;JET;Placebo(for JET)
31 A Clinical Trial to Evaluate the Effectiveness and Safety of Chinese Medicine in the Treatment of Mild Type of Hand, Foot, and Mouth Disease Completed NCT01182532 TCM Syndrome Differentiation and Treatment
32 Study on Dynamic Changes of the Maternal Anti-EV71 and Anti-CVA16 Antibody Levels in Infants and Young Children Completed NCT01255124
33 Five-year Immune Persistence Study of Inactivated Enterovirus Type 71 (EV71) Vaccine Completed NCT03281174
34 Effectiveness and Safety of Chinese Medicine to Treat Hand, Foot, and Mouth Disease Completed NCT01554930 Western therapy (mannitol, methylprednisolone, immunoglobulin, febrifuge);Xiyanping injection plus western therapy
35 Do Traditional or Flavored Tongue Depressors Make for Easier Posterior Oropharynx Exams in Pediatric Patients Completed NCT03095183

Search NIH Clinical Center for Hand, Foot and Mouth Disease

Cochrane evidence based reviews: hand, foot and mouth disease

Genetic Tests for Hand, Foot and Mouth Disease

Anatomical Context for Hand, Foot and Mouth Disease

MalaCards organs/tissues related to Hand, Foot and Mouth Disease:

39
Skin, Tongue, Testes, Brain

Publications for Hand, Foot and Mouth Disease

Articles related to Hand, Foot and Mouth Disease:

(show top 50) (show all 360)
id Title Authors Year
1
Clinical Significance and Prognostic Effect of Serum 25-hydroxyvitamin D Concentrations in Critical and Severe Hand, Foot and Mouth Disease. ( 28489032 )
2017
2
Synonymous codon usage analysis of hand, foot and mouth disease viruses: A comparative study on coxsackievirus A6, A10, A16, and enterovirus 71 from 2008 to 2015. ( 28602802 )
2017
3
Tailoring Diagnostic Studies in Hand, Foot, and Mouth Disease: Utility of PCR testing of Lesional Skin. ( 28940373 )
2017
4
A sudden paediatric death due to hand, foot and mouth disease: the importance of vigilance. ( 28866699 )
2017
5
Spatio-temporal clustering analysis and its determinants of hand, foot and mouth disease in Hunan, China, 2009-2015. ( 28946852 )
2017
6
Severe hand, foot and mouth disease associated with Coxsackievirus A10 infections in Xiamen, China in 2015. ( 28577423 )
2017
7
A Case-control Study on Risk Factors for Severe Hand, Foot and Mouth Disease. ( 28084311 )
2017
8
The exposure-response relationship between temperature and childhood hand, foot and mouth disease: A multicity study from mainland China. ( 28069250 )
2017
9
Antiviral activity of acid beta-glucosidase 1 on enterovirus 71, a causative agent of hand, foot and mouth disease. ( 28141506 )
2017
10
Vitamin D receptor protects glioblastoma A172A cells against Coxsackievirus A16 infection induced cell death in the pathogenesis of hand, foot, and mouth disease. ( 28943436 )
2017
11
Economic costs and health-related quality of life for hand, foot and mouth disease (HFMD) patients in China. ( 28934232 )
2017
12
Epidemiological and genetic analysis concerning the non-enterovirus 71 and non-coxsackievirus A16 causative agents related to hand, foot and mouth disease in Anyang city, Henan Province, China, from 2011 to 2015. ( 28480969 )
2017
13
Derivation and Validation of a Mortality Risk Score for Severe Hand, Foot and Mouth Disease in China. ( 28611398 )
2017
14
Clinical significance of inflammatory cytokine and chemokine expression in hand, foot and mouth disease. ( 28447721 )
2017
15
A mild phenotype of hand, foot and mouth disease caused by Coxsackievirus A6. ( 28681725 )
2017
16
Morphological characteristics of fatal pediatric hand, foot and mouth disease: A clinicopathological study with related receptors of EV71. ( 28756983 )
2017
17
Clinical features for 89 deaths of hand, foot and mouth disease in Guangxi, China, 2014. ( 28882666 )
2017
18
The impact of hand, foot and mouth disease control policies in Singapore: A qualitative analysis of public perceptions. ( 28533530 )
2017
19
Monitoring hand, foot and mouth disease by combining search engine query data and meteorological factors. ( 28898935 )
2017
20
Temporal and spatial analysis of hand, foot, and mouth disease in relation to climate factors: A study in the Mekong Delta region, Vietnam. ( 28063653 )
2017
21
Alteration of serum high-mobility group protein 1 (HMGB1) levels in children with enterovirus 71-induced hand, foot, and mouth disease. ( 28445307 )
2017
22
Genetic characterization of enterovirus strains identified in Hand, Foot and Mouth Disease (HFMD): Emergence of B1c, C1 subgenotypes, E2 sublineage of CVA16, EV71 and CVA6 strains in India. ( 28577914 )
2017
23
Hand, foot, and mouth disease in mainland China before it was listed as category C disease in May, 2008. ( 28948918 )
2017
24
Atypical hand, foot and mouth disease due to Coxsackievirus A6 in a traveler returning from Indonesia to Italy. ( 28498983 )
2017
25
Hand, foot and mouth disease in adult patients. ( 28776773 )
2017
26
Proximal onycholysis as a complication of hand, foot, and mouth disease. ( 28083877 )
2017
27
Epidemiology of 45,616 suspect cases of Hand, Foot and Mouth Disease in Chongqing, China, 2011-2015. ( 28422128 )
2017
28
Therapeutic efficacy of phentolamine in the management of severe hand, foot and mouth disease combined with pulmonary edema. ( 28413485 )
2017
29
Spatiotemporal risk mapping of hand, foot and mouth disease and its association with meteorological variables in children under 5 years. ( 28891456 )
2017
30
Cyclical Patterns of Hand, Foot and Mouth Disease Caused by Enterovirus A71 in Malaysia. ( 27010319 )
2016
31
Transmission of Hand, Foot and Mouth Disease and Its Potential Driving Factors in Hong Kong. ( 27271966 )
2016
32
Changes of circulating Th22 cells in children with hand, foot, and mouth disease caused by enterovirus 71 infection. ( 28030850 )
2016
33
Short-term effects of meteorological factors on hand, foot and mouth disease among children in Shenzhen, China: Non-linearity, threshold and interaction. ( 26386448 )
2016
34
Comparisons between mild and severe cases of hand, foot and mouth disease in temporal trends: a comparative time series study from mainland China. ( 27769194 )
2016
35
Nonlinear and Interactive Effects of Temperature and Humidity on Childhood Hand, Foot and Mouth Disease in Hefei, China. ( 27276180 )
2016
36
Socio-ecological factors and hand, foot and mouth disease in dry climate regions: a Bayesian spatial approach in Gansu, China. ( 27329324 )
2016
37
Age patterns and transmission characteristics of hand, foot and mouth disease in China. ( 27871252 )
2016
38
Two Genotypes of Coxsackievirus A2 Associated with Hand, Foot, and Mouth Disease Circulating in China since 2008. ( 28030650 )
2016
39
Effect of integrated Chinese and Western medicine therapy on severe hand, foot and mouth disease: A prospective, randomized, controlled trial. ( 27392481 )
2016
40
Impact of weather factors on hand, foot and mouth disease, and its role in short-term incidence trend forecast in Huainan City, Anhui Province. ( 27557791 )
2016
41
Neurological complications and risk factors of cardiopulmonary failure of EV-A71-related hand, foot and mouth disease. ( 27001010 )
2016
42
Exacerbation of bullous pemphigoid after hand, foot, and mouth disease treated with rituximab. ( 27051813 )
2016
43
Clinicopathologic analysis of atypical hand, foot, and mouth disease in adult patients. ( 28027826 )
2016
44
Hand, Foot and Mouth Disease in Hong Kong: A Time-Series Analysis on Its Relationship with Weather. ( 27532865 )
2016
45
Coxsackievirus associated hand, foot and mouth disease in an adult. ( 27634973 )
2016
46
Hand Foot and Mouth Disease Like Illness in Office Practice. ( 27943150 )
2016
47
Hand, foot and mouth disease: an overview of clinical features in adult patients. ( 27859744 )
2016
48
Enterovirus-related diarrhoea in Guangdong, China: clinical features and implications in hand, foot and mouth disease and herpangina. ( 26983856 )
2016
49
Immunodominant IgM and IgG Epitopes Recognized by Antibodies Induced in Enterovirus A71-Associated Hand, Foot and Mouth Disease Patients. ( 27806091 )
2016
50
Hand-Washing: The Main Strategy for Avoiding Hand, Foot and Mouth Disease. ( 27322307 )
2016

Variations for Hand, Foot and Mouth Disease

Expression for Hand, Foot and Mouth Disease

Search GEO for disease gene expression data for Hand, Foot and Mouth Disease.

Pathways for Hand, Foot and Mouth Disease

Pathways related to Hand, Foot and Mouth Disease according to GeneCards Suite gene sharing:

(show all 23)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.61 C4A IFNG IL10 IL6
2
Show member pathways
12.33 IFNG IL10 IL17F IL6
3
Show member pathways
12.29 IFNG IL10 IL17F IL6
4
Show member pathways
12.11 IFNG IL17F IL6
5 12.01 IFNG IL10 IL6
6
Show member pathways
11.97 IFNG IL10 IL6
7 11.94 C4A IL10 IL6
8 11.77 IFNG IL10 IL6
9 11.74 IL10 IL17F IL6
10
Show member pathways
11.68 IFNG IL10 IL6
11 11.66 IFNG IL10 IL6
12 11.59 IFNG IL10 IL6
13
Show member pathways
11.59 IFNG IL17F IL6
14 11.43 C4A IL10 IL6
15 11.38 IFNG IL10 IL6
16
Show member pathways
11.21 IFNG IL10
17 11.15 IL10 IL6
18
Show member pathways
11.13 IFNG IL10 IL6 OAS1
19 11.12 IFNG IL10 IL6
20 11.1 IFNG IL6
21 10.99 IFNG IL10
22 10.88 IFNG IL10 IL6
23 10.61 IFNG IL10 IL6

GO Terms for Hand, Foot and Mouth Disease

Cellular components related to Hand, Foot and Mouth Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 C4A CA6 HMGB1 IFNG IL10 IL17F
2 extracellular region GO:0005576 9.28 C4A CA6 HMGB1 IFNG IL10 IL17F

Biological processes related to Hand, Foot and Mouth Disease according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.96 HMGB1 IFNG IL10 IL17F IL6
2 immune response GO:0006955 9.81 IFNG IL10 IL6 OAS1
3 defense response to virus GO:0051607 9.74 IFNG IL6 OAS1
4 cellular response to lipopolysaccharide GO:0071222 9.65 IFNG IL10 IL6
5 response to lipopolysaccharide GO:0032496 9.58 IL10 IL6
6 positive regulation of interleukin-1 beta secretion GO:0050718 9.55 HMGB1 IFNG
7 negative regulation of interferon-gamma production GO:0032689 9.54 HMGB1 IL10
8 response to drug GO:0042493 9.54 IFNG IL10 IL6
9 positive regulation of interleukin-12 production GO:0032735 9.52 HMGB1 IFNG
10 positive regulation of interleukin-6 secretion GO:2000778 9.49 HMGB1 IL17F
11 negative regulation of growth of symbiont in host GO:0044130 9.46 IFNG IL10
12 cellular response to hepatocyte growth factor stimulus GO:0035729 9.43 IL10 IL6
13 response to glucocorticoid GO:0051384 9.43 HMGB1 IL10 IL6
14 positive regulation of protein import into nucleus, translocation GO:0033160 9.4 IFNG IL6
15 positive regulation of MHC class II biosynthetic process GO:0045348 9.32 IFNG IL10
16 negative regulation of smooth muscle cell proliferation GO:0048662 9.28 IFNG
17 neutrophil apoptotic process GO:0001781 9.16 IFNG IL6
18 defense response to protozoan GO:0042832 9.13 IFNG IL10 IL6
19 inflammatory response GO:0006954 9.02 C4A HMGB1 IL10 IL17F IL6

Molecular functions related to Hand, Foot and Mouth Disease according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 HMGB1 IFNG IL10 IL17F IL6

Sources for Hand, Foot and Mouth Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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