MCID: HNG003
MIFTS: 36

Hangover malady

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Summaries for Hangover

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Wikipedia:65 A hangover /?h more...

MalaCards based summary: Hangover is related to alcohol dependence and headache. An important gene associated with Hangover is ALDH2 (aldehyde dehydrogenase 2 family (mitochondrial)), and among its related pathways are Valine, leucine and isoleucine degradation and Lysine degradation. The compounds alda 1 and win 18446 have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and heart.

Description from OMIM:46 610251

Aliases & Classifications for Hangover

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Hangover, Aliases & Descriptions:

Name: Hangover 46


Related Diseases for Hangover

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Graphical network of the top 20 diseases related to Hangover:



Diseases related to hangover

Symptoms for Hangover

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Clinical features from OMIM:

610251

Drugs & Therapeutics for Hangover

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Drug clinical trials:

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Genetic Tests for Hangover

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Anatomical Context for Hangover

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MalaCards organs/tissues related to Hangover:

32
Brain, Cortex, Heart, Liver

Animal Models for Hangover or affiliated genes

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Publications for Hangover

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Articles related to Hangover:

(show top 50)    (show all 187)
idTitleAuthorsYear
1
Driving during alcohol hangover among dutch professional truck drivers. (24678564)
2014
2
Heritability of usual alcohol intoxication and hangover in male twins: the NAS-NRC twin registry. (25156618)
2014
3
The effect of constant darkness and circadian resynchronization on the recovery of alcohol hangover. (24717330)
2014
4
Editorial: Can Hangover Immunity be Really Claimed? (25311093)
2014
5
Alterations in affective behavior during the time course of alcohol hangover. (23850352)
2013
6
Effect of Korean pear (Pyruspyrifolia cv. Shingo) juice on hangover severity following alcohol consumption. (23587660)
2013
7
Interactions between migraine and tension-type headache and alcohol drinking, alcohol flushing, and hangover in Japanese. (22234728)
2012
8
Hangover Predicts Residual Alcohol Effects on Psychomotor Vigilance the Morning After Intoxication. (21643431)
2010
9
Effects of cryopreservation of recalcitrant Amaryllis belladonna zygotic embryos on vigor of recovered seedlings: a case of stress 'hangover'? (20113434)
2010
10
Health. Sweet (hangover) relief. (20535914)
2010
11
Subjective responses to alcohol prime event-specific alcohol consumption and predict blackouts and hangover. (19515300)
2009
12
The "hair of the dog": a useful hangover remedy or a predictor of future problem drinking? (19630732)
2009
13
Effects of a preparation of combined glutathione-enriched yeast and rice embryo/soybean extracts on ethanol hangover. (20041794)
2009
14
The alcohol hangover--a puzzling phenomenon. (18182417)
2008
15
Neurocognitive effects of alcohol hangover. (17543471)
2008
16
Concentration changes of methanol in blood samples during an experimentally induced alcohol hangover state. (16318957)
2005
17
Interventions for preventing or treating alcohol hangover: systematic review of randomised controlled trials. (16373736)
2005
18
Hangover frequency and risk for alcohol use disorders: evidence from a longitudinal high-risk study. (15869353)
2005
19
Effects of fusel oil on animal hangover models. (12960505)
2003
20
The effects of alcohol hangover on cognitive functions in healthy subjects. (12856484)
2003
21
Comparison of hangover effects among triazolam, flunitrazepam and quazepam in healthy subjects: a preliminary report. (12753571)
2003
22
Alcohol hangover effects on memory functioning and vigilance performance after an evening of binge drinking. (12655320)
2003
23
Hangover symptoms in Asian Americans with variations in the aldehyde dehydrogenase (ALDH2) gene. (10627091)
2000
24
The alcohol hangover. (10836917)
2000
25
An examination of next-day hangover effects after a 100 mg/100 ml dose of alcohol in heavy social drinkers. (9926571)
1998
26
Effect of ethanol drinking, hangover, and exercise on adrenergic activity and heart rate variability in patients with a history of alcohol-induced atrial fibrillation. (9708660)
1998
27
The paradoxical hedonic valence of acute ethanol withdrawal (hangover) states in rats: place and taste conditioning. (9160804)
1997
28
The discriminative stimulus properties of acute ethanol withdrawal (hangover) in rats. (1590555)
1992
29
Concentrations of blood and urine ethanol, acetaldehyde, acetate and acetone during experimental hangover in volunteers. (1785958)
1991
30
A Talmudic hangover. (2896954)
1988
31
The hangover hypothesis and the influence of moderate social drinking on mental ability. (3279856)
1988
32
Objective and subjective assessment of hangover during subacute administration of temazepam and nitrazepam to healthy subjects. (6145593)
1984
33
Drunkenness, hangover, and the heart. (6837336)
1983
34
Effects of ethanol intoxication and hangover on plasma levels of thromboxane B2 and 6-keto-prostaglandin F1 alpha and on thromboxane B2 formation by platelets in man. (7179202)
1982
35
Negative affect, alcohol consumption and hangover symptoms among normal drinkers in a small community. (7334809)
1981
36
Fetal alcohol syndrome--the incurable hangover. (6915025)
1981
37
Laboratory performance during acute alcohol intoxication and hangover. (7429513)
1980
38
Performance effects of alcohol intoxication and hangover at ground level and at simulated altitude. (7369966)
1980
39
Adenosine 3',5' cyclic monophosphate, calcium and magnesium excretion in ethanol intoxication and hangover. (232365)
1979
40
The effect of an hypnotic with a short half-life on hangover effect in old patients. (727060)
1978
41
Metabolic and endocrine pathology during hangover. (596284)
1977
42
Effects of hangover on psychomotor skills related to driving: modification by fructose and glucose. (988956)
1976
43
An early American hangover: the medical profession and intemperance 1800-1860. (791411)
1976
44
Electroencephalographic changes during experimental hangover. (57042)
1976
45
Human auditory evoked responses during hangover. (1161976)
1975
46
Hangover effects of hypnotics in man. (5572307)
1971
47
Hangover effect of hypnotics in man. (4925471)
1971
48
The physiological mechanism involved in hangover. 1. The oxidation of some lower aliphatic fusel alcohols and aldehydes in rat liver and their effect on the mitochondrial oxidation of various substrates. (5395760)
1969
49
Physical performance during hangover. (14454097)
1962
50
Alcohol, tranquilizers and hangover. (13899701)
1961

Variations for Hangover

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Expression for genes affiliated with Hangover

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Expression patterns in normal tissues for genes affiliated with Hangover

Search GEO for disease gene expression data for Hangover.

Pathways for genes affiliated with Hangover

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Pathways related to Hangover according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
beta-alanine degradation I37
valine degradation I37
pyruvate fermentation to lactate37
isoleucine degradation I37
9.5ALDH9A1, ALDH2
29.5ALDH2, ALDH9A1
3
Show member pathways
citrulline-nitric oxide cycle37
arginine degradation I (arginase pathway)37
proline degradation37
glutamine degradation I37
proline biosynthesis I37
superpathway of citrulline metabolism37
proline biosynthesis II (from arginine)37
citrulline biosynthesis37
arginine degradation VI (arginase 2 pathway)37
Urea cycle and metabolism of amino groups37
asparagine biosynthesis I37
4-hydroxyproline degradation I37
citrulline degradation37
9.5ALDH2, ALDH9A1
4
Show member pathways
mitochondrial L-carnitine shuttle pathway37
Saturated fatty acid biosynthesis60
9.5ALDH2, ALDH9A1
5
Show member pathways
9.5ALDH2, ALDH9A1
6
Show member pathways
phenylethylamine degradation I37
9.5ALDH2, ALDH9A1
7
Show member pathways
methylglyoxal degradation VI37
methylglyoxal degradation I37
9.5ALDH9A1, ALDH2
8
Show member pathways
histamine biosynthesis37
9.5ALDH2, ALDH9A1
9
Show member pathways
9.2ALDH2, AKR1A1
10
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)37
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA37
tryptophan degradation37
glutaryl-CoA degradation37
serotonin degradation37
NAD de novo biosynthesis37
superpathway of melatonin degradation37
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde37
tryptophan utilization I37
melatonin degradation I37
9.2AKR1A1, ALDH2
11
Show member pathways
Retinol metabolism60
9.0ALDH2, ALDH1A2, ALDH9A1
12
Show member pathways
9.0ALDH2, ALDH1A2, ALDH9A1
13
Show member pathways
8.7AKR1A1, ALDH9A1, ALDH2
14
Show member pathways
glycolysis37
gluconeogenesis37
Glycolysis and Gluconeogenesis37
8.7AKR1A1, ALDH9A1, ALDH2
15
Show member pathways
8.2AKR1A1, ALDH9A1, ALDH1A2, ALDH2

Compounds for genes affiliated with Hangover

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Compounds related to Hangover according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1alda 1619.9ALDH2, ALDH1A2
2win 18446619.9ALDH2, ALDH1A2
3decanal44 2410.9ALDH2, ALDH1A2
4chloralhydrate449.9ALDH9A1, ALDH2
520-oxo-leukotriene B4249.9ALDH2, ALDH9A1
620-Oxo-leukotriene E4249.9ALDH2, ALDH9A1
7Spermic acid 2249.9ALDH2, ALDH9A1
8Spermine dialdehyde249.9ALDH2, ALDH9A1
9daidzin44 1110.9ALDH9A1, ALDH2
10aldophosphamide449.9ALDH2, ALDH9A1
11citral449.8ALDH1A2, ALDH9A1
12Imidazole-4-acetaldehyde249.8ALDH2, ALDH9A1
13Imidazoleacetic acid249.8ALDH2, ALDH9A1
14Indoleacetic acid249.8ALDH2, ALDH9A1
15Perillyl aldehyde249.8ALDH2, ALDH9A1
16Propynoic acid249.8ALDH2, ALDH9A1
174-Trimethylammoniobutanal249.8ALDH9A1, ALDH2
182-Propyn-1-al249.8ALDH2, ALDH9A1
193-Butyn-1-al249.7ALDH2, ALDH9A1
204-Acetamidobutanoic acid249.7ALDH2, ALDH9A1
214-Aminobutyraldehyde249.7ALDH2, ALDH9A1
224-Trimethylammoniobutanoic acid249.7ALDH9A1, ALDH2
23N4-Acetylaminobutanal249.6ALDH9A1, ALDH2
24Indoleacetaldehyde249.6ALDH9A1, ALDH2
25Glyceric acid249.6ALDH9A1, ALDH2
262-chloroethanol449.5ALDH9A1, AKR1A1
27cinnamaldehyde28 4410.5ALDH9A1, AKR1A1
28D-Glucurono-6,3-lactone249.5ALDH9A1, ALDH2
29betaine aldehyde44 2410.5ALDH2, ALDH9A1
305-hydroxytryptophol449.5ALDH9A1, AKR1A1
31chloroacetaldehyde449.5ALDH9A1, AKR1A1
324-methylpyrazole449.5AKR1A1, ALDH9A1
33retinaldehyde449.4ALDH2, ALDH1A2, ALDH9A1
34thymol28 4410.4ALDH9A1, AKR1A1
35perillic acid44 2410.2ALDH9A1, ALDH2
36propionaldehyde449.1ALDH2, ALDH9A1, AKR1A1
37benzaldehyde44 2410.1AKR1A1, ALDH9A1, ALDH2
38glyceraldehyde44 2410.1ALDH2, ALDH9A1, AKR1A1
39hydride449.1AKR1A1, ALDH9A1, ALDH2
40rsai449.1AKR1A1, ALDH9A1, ALDH2
41disulfiram44 50 61 1112.1AKR1A1, ALDH9A1, ALDH2
42acetic acid44 28 24 1112.1AKR1A1, ALDH9A1, ALDH2
434-hydroxynonenal44 2410.1AKR1A1, ALDH9A1, ALDH2
44carbodiimide449.0AKR1A1, ALDH9A1
45nad+449.0ALDH2, ALDH9A1, AKR1A1
46acetaldehyde28 44 2410.6ALDH2, ALDH1A2, ALDH9A1, AKR1A1
47vitamin a44 24 1110.6ALDH2, ALDH1A2, ALDH9A1, AKR1A1
48retinoid448.6ALDH2, ALDH1A2, ALDH9A1, AKR1A1
49nad28 249.6AKR1A1, ALDH9A1, ALDH1A2, ALDH2
50nadh44 24 1110.6ALDH2, ALDH1A2, ALDH9A1, AKR1A1

GO Terms for genes affiliated with Hangover

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Biological processes related to Hangover according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1kidney developmentGO:0018229.4ALDH1A2, ALDH9A1
2neurotransmitter biosynthetic processGO:0421369.4ALDH2, ALDH9A1
3cellular aldehyde metabolic processGO:0060819.1ALDH9A1, AKR1A1
4liver developmentGO:0018899.1ALDH1A2, ALDH9A1

Molecular functions related to Hangover according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1electron carrier activityGO:0090559.2ALDH2, AKR1A1
23-chloroallyl aldehyde dehydrogenase activityGO:0040289.1ALDH1A2, ALDH9A1

Products for genes affiliated with Hangover

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  • Antibodies
  • Proteins
  • Lysates

Sources for Hangover

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet