MCID: HNG003
MIFTS: 36

Hangover malady

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Summaries for Hangover

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65Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:65 A hangover /?h more...

MalaCards: Hangover is related to alcohol dependence and headache. An important gene associated with Hangover is ALDH2 (aldehyde dehydrogenase 2 family (mitochondrial)), and among its related pathways are Valine, leucine and isoleucine degradation and Lysine degradation. The compounds alda 1 and win 18446 have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and liver.

Description from OMIM:47 610251

Aliases & Classifications for Hangover

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47OMIM
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Aliases & Descriptions:

hangover 47


Related Diseases for Hangover

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Hangover:



Diseases related to hangover

Symptoms for Hangover

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47OMIM
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Clinical features from OMIM:

610251

Drugs & Therapeutics for Hangover

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Hangover

Search NIH Clinical Center for Hangover

Genetic Tests for Hangover

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Anatomical Context for Hangover

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33MalaCards
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MalaCards organs/tissues related to Hangover:

33
Brain, Heart, Liver, Cortex

Animal Models for Hangover or affiliated genes

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Publications for Hangover

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52PubMed
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Articles related to Hangover:

(show top 50)    (show all 172)
idTitleAuthorsYear
1
Alterations in affective behavior during the time course of alcohol hangover. (23850352)
2013
2
Effect of Korean pear (Pyruspyrifolia cv. Shingo) juice on hangover severity following alcohol consumption. (23587660)
2013
3
Interactions between migraine and tension-type headache and alcohol drinking, alcohol flushing, and hangover in Japanese. (22234728)
2012
4
A hangover remedy for the holidays? (21280248)
2011
5
Hangover Predicts Residual Alcohol Effects on Psychomotor Vigilance the Morning After Intoxication. (21643431)
2010
6
Effects of cryopreservation of recalcitrant Amaryllis belladonna zygotic embryos on vigor of recovered seedlings: a case of stress 'hangover'? (20113434)
2010
7
Health. Sweet (hangover) relief. (20535914)
2010
8
The alcohol hangover research group consensus statement on best practice in alcohol hangover research. (20712593)
2010
9
Subjective responses to alcohol prime event-specific alcohol consumption and predict blackouts and hangover. (19515300)
2009
10
The "hair of the dog": a useful hangover remedy or a predictor of future problem drinking? (19630732)
2009
11
Effects of a preparation of combined glutathione-enriched yeast and rice embryo/soybean extracts on ethanol hangover. (20041794)
2009
12
The alcohol hangover--a puzzling phenomenon. (18182417)
2008
13
Neurocognitive effects of alcohol hangover. (17543471)
2008
14
Concentration changes of methanol in blood samples during an experimentally induced alcohol hangover state. (16318957)
2005
15
Interventions for preventing or treating alcohol hangover: systematic review of randomised controlled trials. (16373736)
2005
16
Hangover frequency and risk for alcohol use disorders: evidence from a longitudinal high-risk study. (15869353)
2005
17
The alcohol hangover and its potential impact on the UK armed forces: a review of the literature on post-alcohol impairment. (15624406)
2004
18
Effect of Opuntia ficus indica on symptoms of the alcohol hangover. (15226168)
2004
19
Effects of fusel oil on animal hangover models. (12960505)
2003
20
The effects of alcohol hangover on cognitive functions in healthy subjects. (12856484)
2003
21
Comparison of hangover effects among triazolam, flunitrazepam and quazepam in healthy subjects: a preliminary report. (12753571)
2003
22
Alcohol hangover effects on memory functioning and vigilance performance after an evening of binge drinking. (12655320)
2003
23
Are there hangover-effects on physical performance when melatonin is ingested by athletes before nocturnal sleep? (11354528)
2001
24
Hangover symptoms in Asian Americans with variations in the aldehyde dehydrogenase (ALDH2) gene. (10627091)
2000
25
The alcohol hangover. (10836917)
2000
26
An examination of next-day hangover effects after a 100 mg/100 ml dose of alcohol in heavy social drinkers. (9926571)
1998
27
Effect of ethanol drinking, hangover, and exercise on adrenergic activity and heart rate variability in patients with a history of alcohol-induced atrial fibrillation. (9708660)
1998
28
The paradoxical hedonic valence of acute ethanol withdrawal (hangover) states in rats: place and taste conditioning. (9160804)
1997
29
The discriminative stimulus properties of acute ethanol withdrawal (hangover) in rats. (1590555)
1992
30
A Talmudic hangover. (2896954)
1988
31
The hangover hypothesis and the influence of moderate social drinking on mental ability. (3279856)
1988
32
Objective and subjective assessment of hangover during subacute administration of temazepam and nitrazepam to healthy subjects. (6145593)
1984
33
Drunkenness, hangover, and the heart. (6837336)
1983
34
Effects of ethanol intoxication and hangover on plasma levels of thromboxane B2 and 6-keto-prostaglandin F1 alpha and on thromboxane B2 formation by platelets in man. (7179202)
1982
35
Negative affect, alcohol consumption and hangover symptoms among normal drinkers in a small community. (7334809)
1981
36
Fetal alcohol syndrome--the incurable hangover. (6915025)
1981
37
Laboratory performance during acute alcohol intoxication and hangover. (7429513)
1980
38
Performance effects of alcohol intoxication and hangover at ground level and at simulated altitude. (7369966)
1980
39
Adenosine 3',5' cyclic monophosphate, calcium and magnesium excretion in ethanol intoxication and hangover. (232365)
1979
40
The effect of an hypnotic with a short half-life on hangover effect in old patients. (727060)
1978
41
Metabolic and endocrine pathology during hangover. (596284)
1977
42
Effects of hangover on psychomotor skills related to driving: modification by fructose and glucose. (988956)
1976
43
An early American hangover: the medical profession and intemperance 1800-1860. (791411)
1976
44
Electroencephalographic changes during experimental hangover. (57042)
1976
45
Human auditory evoked responses during hangover. (1161976)
1975
46
Hangover effects of hypnotics in man. (5572307)
1971
47
Hangover effect of hypnotics in man. (4925471)
1971
48
The physiological mechanism involved in hangover. 1. The oxidation of some lower aliphatic fusel alcohols and aldehydes in rat liver and their effect on the mitochondrial oxidation of various substrates. (5395760)
1969
49
Physical performance during hangover. (14454097)
1962
50
Alcohol, tranquilizers and hangover. (13899701)
1961

Variations for Hangover

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Expression for genes affiliated with Hangover

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hangover

Search GEO for disease gene expression data for Hangover.

Pathways for genes affiliated with Hangover

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50PathCards, 30KEGG, 38NCBI BioSystems Database, 55Reactome, 60Thomson Reuters, 51PharmGKB
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Pathways related to Hangover according to GeneCards/GeneDecks:

(show all 15)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
beta-alanine degradation I38
valine degradation I38
pyruvate fermentation to lactate38
isoleucine degradation I38
9.5ALDH9A1, ALDH2
29.5ALDH2, ALDH9A1
3
Show member pathways
citrulline-nitric oxide cycle38
arginine degradation I (arginase pathway)38
proline degradation38
glutamine degradation I38
proline biosynthesis I38
superpathway of citrulline metabolism38
proline biosynthesis II (from arginine)38
citrulline biosynthesis38
arginine degradation VI (arginase 2 pathway)38
Urea cycle and metabolism of amino groups38
asparagine biosynthesis I38
4-hydroxyproline degradation I38
citrulline degradation38
9.5ALDH2, ALDH9A1
4
Show member pathways
mitochondrial L-carnitine shuttle pathway38
Saturated fatty acid biosynthesis60
9.5ALDH2, ALDH9A1
5
Show member pathways
9.5ALDH2, ALDH9A1
6
Show member pathways
phenylethylamine degradation I38
9.5ALDH2, ALDH9A1
7
Show member pathways
methylglyoxal degradation VI38
methylglyoxal degradation I38
9.5ALDH9A1, ALDH2
8
Show member pathways
histamine biosynthesis38
9.5ALDH2, ALDH9A1
9
Show member pathways
9.2ALDH2, AKR1A1
10
Show member pathways
tryptophan degradation X (mammalian, via tryptamine)38
2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA38
tryptophan degradation38
glutaryl-CoA degradation38
serotonin degradation38
NAD de novo biosynthesis38
superpathway of melatonin degradation38
tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde38
tryptophan utilization I38
melatonin degradation I38
9.2AKR1A1, ALDH2
11
Show member pathways
Retinol metabolism60
9.0ALDH2, ALDH1A2, ALDH9A1
12
Show member pathways
9.0ALDH2, ALDH1A2, ALDH9A1
13
Show member pathways
8.7AKR1A1, ALDH9A1, ALDH2
14
Show member pathways
glycolysis38
gluconeogenesis38
Glycolysis and Gluconeogenesis38
8.7AKR1A1, ALDH9A1, ALDH2
15
Show member pathways
8.2AKR1A1, ALDH9A1, ALDH1A2, ALDH2

Compounds for genes affiliated with Hangover

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Sources:
61Tocris Bioscience, 45Novoseek, 24HMDB, 11DrugBank, 29IUPHAR, 51PharmGKB
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Compounds related to Hangover according to GeneCards/GeneDecks:

(show top 50)    (show all 89)
idCompoundScoreTop Affiliating Genes
1alda 1619.9ALDH2, ALDH1A2
2win 18446619.9ALDH1A2, ALDH2
3decanal45 2410.9ALDH1A2, ALDH2
4aldophosphamide459.9ALDH2, ALDH9A1
5chloralhydrate459.9ALDH9A1, ALDH2
620-oxo-leukotriene B4249.9ALDH9A1, ALDH2
7Spermic acid 2249.9ALDH9A1, ALDH2
8Spermine dialdehyde249.9ALDH2, ALDH9A1
9daidzin45 1110.9ALDH9A1, ALDH2
10citral459.9ALDH1A2, ALDH9A1
1120-Oxo-leukotriene E4249.8ALDH2, ALDH9A1
12Imidazoleacetic acid249.8ALDH2, ALDH9A1
13Imidazole-4-acetaldehyde249.8ALDH9A1, ALDH2
143-Butyn-1-al249.8ALDH9A1, ALDH2
15Propynoic acid249.8ALDH9A1, ALDH2
16Indoleacetic acid249.8ALDH9A1, ALDH2
17Perillyl aldehyde249.8ALDH9A1, ALDH2
184-Trimethylammoniobutanal249.8ALDH9A1, ALDH2
194-Aminobutyraldehyde249.8ALDH9A1, ALDH2
202-Propyn-1-al249.7ALDH2, ALDH9A1
214-Acetamidobutanoic acid249.7ALDH2, ALDH9A1
224-Trimethylammoniobutanoic acid249.7ALDH9A1, ALDH2
23perillic acid45 2410.6ALDH2, ALDH9A1
24N4-Acetylaminobutanal249.6ALDH9A1, ALDH2
252-chloroethanol459.5ALDH9A1, AKR1A1
265-hydroxytryptophol459.5ALDH9A1, AKR1A1
27Indoleacetaldehyde249.5ALDH9A1, ALDH2
28betaine aldehyde45 2410.5ALDH9A1, ALDH2
29chloroacetaldehyde459.5ALDH9A1, AKR1A1
30cinnamaldehyde29 4510.5AKR1A1, ALDH9A1
314-methylpyrazole459.5ALDH9A1, AKR1A1
32retinaldehyde459.4ALDH2, ALDH9A1, ALDH1A2
33Glyceric acid249.4ALDH2, ALDH9A1
34thymol29 4510.4ALDH9A1, AKR1A1
35carbodiimide459.2ALDH9A1, AKR1A1
36D-Glucurono-6,3-lactone249.2ALDH9A1, ALDH2
37propionaldehyde459.1ALDH2, ALDH9A1, AKR1A1
38benzaldehyde45 2410.1ALDH2, ALDH9A1, AKR1A1
39glyceraldehyde45 2410.1AKR1A1, ALDH9A1, ALDH2
40hydride459.1ALDH2, ALDH9A1, AKR1A1
41rsai459.1ALDH9A1, AKR1A1, ALDH2
42disulfiram45 51 61 1112.1AKR1A1, ALDH2, ALDH9A1
43acetic acid45 29 24 1112.1ALDH2, ALDH9A1, AKR1A1
444-hydroxynonenal45 2410.1AKR1A1, ALDH9A1, ALDH2
45nad+459.0AKR1A1, ALDH2, ALDH9A1
46acetaldehyde29 45 2410.6ALDH1A2, ALDH2, AKR1A1, ALDH9A1
47vitamin a45 24 1110.6ALDH2, ALDH1A2, ALDH9A1, AKR1A1
48retinoid458.6ALDH1A2, ALDH2, AKR1A1, ALDH9A1
49nad29 249.6ALDH1A2, ALDH9A1, AKR1A1, ALDH2
50nadh45 24 1110.6ALDH1A2, AKR1A1, ALDH9A1, ALDH2

GO Terms for genes affiliated with Hangover

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16Gene Ontology
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Biological processes related to Hangover according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1kidney developmentGO:0018229.4ALDH1A2, ALDH9A1
2neurotransmitter biosynthetic processGO:0421369.4ALDH2, ALDH9A1
3cellular aldehyde metabolic processGO:0060819.1ALDH9A1, AKR1A1
4liver developmentGO:0018899.1ALDH1A2, ALDH9A1

Molecular functions related to Hangover according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1electron carrier activityGO:0090559.2ALDH2, AKR1A1
23-chloroallyl aldehyde dehydrogenase activityGO:0040289.1ALDH1A2, ALDH9A1

Products for genes affiliated with Hangover

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hangover

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet