MCID: HNS001
MIFTS: 31

Hansen's Disease

Categories: Rare diseases

Aliases & Classifications for Hansen's Disease

MalaCards integrated aliases for Hansen's Disease:

Name: Hansen's Disease 49 3
Leprosy 49 69

Classifications:



Summaries for Hansen's Disease

NIH Rare Diseases : 49 Hansen's disease (also known as leprosy) is a rare bacterial infection that affects the skin, nerves and mucous membranes. After exposure, it may take anywhere from 2 to 10 years to develop features of the condition. Once present, common signs and symptoms include skin lesions; muscle weakness or paralysis; eye problems that may lead to blindness; nosebleeds; severe pain; and/or numbness in the hands, feet, arms and legs. Hansen's disease is caused by the bacterium Mycobacterium leprae; however, the way in which the bacterium is transmitted (spread) is poorly understood. It appears that only about 5% of people are susceptible to the condition. Hansen's disease is easily treated with combination antibiotics for 6 months to 2 years. Last updated: 4/26/2015

MalaCards based summary : Hansen's Disease, also known as leprosy, is related to leprosy 3 and lepromatous leprosy. An important gene associated with Hansen's Disease is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2). The drugs Rifampin and Isoniazid have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes.

Related Diseases for Hansen's Disease

Diseases related to Hansen's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 275)
# Related Disease Score Top Affiliating Genes
1 leprosy 3 12.7
2 lepromatous leprosy 12.5
3 tuberculoid leprosy 12.5
4 borderline leprosy 12.5
5 leprosy 1 12.4
6 indeterminate leprosy 12.4
7 leprosy 2 12.1
8 leprosy 5 12.1
9 leprosy 6 12.0
10 leprosy 4 12.0
11 mononeuritis multiplex 11.2
12 chronic rhinitis 11.2
13 fetal thalidomide syndrome 11.2
14 trigeminal trophic syndrome 11.2
15 buruli ulcer 10.8
16 macs syndrome 10.8
17 sensory peripheral neuropathy 10.8
18 peripheral nervous system disease 10.8
19 mycobacterium kansasii 10.8
20 mycobacterium tuberculosis 1 10.2
21 lagophthalmos 10.1
22 neuropathy 10.1
23 foot drop 10.1
24 episodic pain syndrome, familial, 1 10.0
25 hepatitis 10.0
26 allergic hypersensitivity disease 10.0
27 neuritis 10.0
28 kala-azar 1 10.0
29 leishmaniasis 10.0
30 syphilis 9.9
31 luscan-lumish syndrome 9.9
32 arthritis 9.9
33 pulmonary tuberculosis 9.9
34 molluscum contagiosum 9.9
35 glomerulonephritis 9.9
36 lymphoma 9.9
37 lupus erythematosus 9.9
38 amyloidosis 9.9
39 blood group, i system 9.9
40 systemic lupus erythematosus 9.9
41 aging 9.9
42 complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy 9.8
43 parkinson disease 2, autosomal recessive juvenile 9.8
44 malaria 9.8
45 thrombosis 9.8
46 tetanus 9.8
47 chromoblastomycosis 9.8
48 iridocyclitis 9.8
49 mycosis fungoides 9.8
50 hepatitis b 9.8

Graphical network of the top 20 diseases related to Hansen's Disease:



Diseases related to Hansen's Disease

Symptoms & Phenotypes for Hansen's Disease

Drugs & Therapeutics for Hansen's Disease

Drugs for Hansen's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 139)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rifampin Approved Phase 4,Phase 2,Phase 3,Phase 1 13292-46-1 5381226 5458213
2
Isoniazid Approved, Investigational Phase 4,Phase 1 54-85-3 3767
3
Dapsone Approved, Investigational Phase 4,Phase 1,Phase 2 80-08-0 2955
4
Clofazimine Approved, Investigational Phase 4,Phase 1,Phase 2 2030-63-9 2794
5
leucovorin Approved, Nutraceutical Phase 4,Phase 1,Phase 2 58-05-9 143 6006
6
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 59-30-3 6037
7 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
8 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
9 Folic Acid Antagonists Phase 4,Phase 1,Phase 2
10 Cytochrome P-450 CYP3A Inducers Phase 4,Phase 2,Phase 3,Phase 1
11 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
12 Vitamin B Complex Phase 4,Phase 1,Phase 2
13 Vitamins Phase 4
14 Hypolipidemic Agents Phase 4,Phase 1
15 Antimalarials Phase 4,Phase 1,Phase 2
16 Antimetabolites Phase 4,Phase 1
17 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
18 Lipid Regulating Agents Phase 4,Phase 1
19 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Phase 1
20 Antiprotozoal Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
21 Antiparasitic Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
22 Antitubercular Agents Phase 4,Phase 2,Phase 3,Phase 1
23 Folate Nutraceutical Phase 4,Phase 1,Phase 2
24 Vitamin B9 Nutraceutical Phase 4,Phase 1,Phase 2
25
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
26
Goserelin Approved Phase 3 65807-02-5 5311128 47725
27
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
28
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
29
Leuprolide Approved, Investigational Phase 3 53714-56-0 657181 3911
30
Miltefosine Approved, Investigational Phase 3 58066-85-6 3600
31
Streptomycin Approved, Vet_approved Phase 2, Phase 3,Phase 1 57-92-1 19649
32
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
33
Benzoyl peroxide Approved Phase 3 94-36-0 7187
34
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
35
Aluminum sulfate Approved Phase 2, Phase 3 10043-01-3
36
Amitriptyline Approved Phase 3 50-48-6 2160
37
Perphenazine Approved Phase 3 58-39-9 4748
38
Tramadol Approved, Investigational Phase 3 27203-92-5 33741
39
Clarithromycin Approved Phase 2, Phase 3 81103-11-9 84029
40
Infliximab Approved Phase 3 170277-31-3
41 Hormone Antagonists Phase 2, Phase 3
42 Hormones Phase 2, Phase 3
43 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
44 meglumine antimoniate Phase 3,Early Phase 1
45 Prednisolone acetate Phase 2, Phase 3
46 glucocorticoids Phase 2, Phase 3
47 Fertility Agents Phase 3
48 Methylprednisolone acetate Phase 2, Phase 3
49 Methylprednisolone Hemisuccinate Phase 2, Phase 3
50 Adjuvants, Immunologic Phase 2, Phase 3

Interventional clinical trials:

(show all 50)

# Name Status NCT ID Phase Drugs
1 Effect of Additional Clofazimine on Erythema Nodosum Leprosum (ENL) Reactions in Leprosy Completed NCT01290744 Phase 4 Clofazimine;Placebo
2 Uniform Multidrug Therapy Regimen for Leprosy Patients Completed NCT00669643 Phase 4 PB 6 doses - Rifampicin and Dapsone;PB 6 doses - Rifampicin, Clofazimine and Dapsone;MB 12 doses - Rifampicin, Clofazimine and Dapsone;MB 6 doses - Rifampicin, Clofazimine and Dapsone
3 Effect of Weight and/or Obesity on Dapsone Drug Concentrations Completed NCT01165840 Phase 4 Dapsone
4 Feasibility and Effectiveness of Community Based Isoniazid Preventive Therapy in Kenya Completed NCT00850915 Phase 4
5 Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome Recruiting NCT02550080 Phase 4 Dapsone
6 Minocycline Therapy for Lung Scarring in Patients With Idiopathic Pulmonary Fibrosis - a Pilot Study Unknown status NCT00203697 Phase 3 minocycline
7 Ciclosporin in the Management of New Type 1 Reactions in Leprosy Completed NCT00919815 Phase 2, Phase 3 Ciclosporin;Prednisolone
8 Safety/Efficacy Trial of Killed Leishmania Vaccine in Volunteers With Positive Response to Leishmanin (LST>0) Completed NCT00429780 Phase 2, Phase 3
9 Safety/Efficacy Trial of Killed Leishmania Vaccine in Volunteers With no Response to Leishmanin Completed NCT00429715 Phase 2, Phase 3
10 Efficacy and Safety of Immunomodulator as an Adjunct Therapy in New Pulmonary Tuberculosis(Category I) Patients. Completed NCT00341328 Phase 3
11 Efficacy and Safety Study of Immunomodulator as an Adjunct Therapy in Pulmonary Tuberculosis (TB) Retreatment Patients Completed NCT00265226 Phase 3
12 Thalidomide for the Treatment of Hormone-Dependent Prostate Cancer Completed NCT00004635 Phase 3 Thalidomide;leuprolide acetate;goserelin
13 Efficacy Trial on Oral Miltefosine in Comparison With Glucantime in the Treatment of ACL Caused by L. Tropica Completed NCT00351520 Phase 3 Miltefose
14 To Compare the Efficacy and Safety of Clindamycin Phosphate 1.2% / Benzoyl Peroxide 5% Gel of CHL Versus DUAC® Gel Completed NCT02005666 Phase 3 Clindamycin Phosphate 1.2% / Benzoyl Peroxide 5% Gel;DUAC® Gel;Placebo
15 Treatment of Neuropathic Pain in Leprosy Recruiting NCT03324035 Phase 3 Amitriptyline;Placebo oral capsule;Tramadol
16 WHO Drug Study for Buruli Ulcer - Comparison of SR8 and CR8 Active, not recruiting NCT01659437 Phase 2, Phase 3 Clarithromycin Extended Release;Streptomycin intramuscular injection
17 Thalidomide Versus Infliximab in New Onset Crohn's Disease With Poor Prognostic Factors Not yet recruiting NCT03221166 Phase 3 Thalidomide;Infliximab
18 Leprosy Skin Test Antigens Trial Completed NCT00128193 Phase 2
19 Ciclosporin in the Management of Steroid Resistant Type 1 Reactions in Leprosy Completed NCT00919451 Phase 2 ciclosporin
20 Ciclosporin in the Management of Chronic or Recurrent Erythema Nodosum Leprosum Completed NCT00919776 Phase 2 prednisolone;ciclosporin
21 Ciclosporin in the Management of New Erythema Nodosum Leprosum Completed NCT00919542 Phase 2 Ciclosporin;prednisolone
22 Phase II Trial of Peginterferon Alpha-2b and Thalidomide in Adults With Recurrent Gliomas Completed NCT00047879 Phase 2 Thalidomide
23 Progression of HIV-Disease Under Low Dose Corticosteroids Completed NCT01299948 Phase 2 Prednisolone
24 A Study to Evaluate the Efficacy and Safety of Bedaquiline (TMC207) in Participants With Multibacillary Leprosy Not yet recruiting NCT03384641 Phase 2 Bedaquiline 200 mg
25 Virgin Coconut Oil Oral Supplementation for Leprosy Patients Withdrawn NCT01885611 Phase 1, Phase 2
26 Prevention of Disability: Proposal for a Guidance Manual for Leprosy Patients Completed NCT01006759 Phase 1
27 Leprosy Skin Test Antigens Phase 1 Completed NCT01920750 Phase 1
28 Study of the Safety and Immunogenicity of Bacille Calmette Guerin (BCG) Vaccine Completed NCT00654316 Phase 1
29 Measurement of Anti-TB Drugs in Lung Tissue From Patients Having Surgery to Treat Tuberculosis Completed NCT00816426 Phase 1 Rifampicin;Isoniazid;Pyrazinamide;Kanamycin;Moxifloxacin
30 Phase 1 LEP-F1 + GLA-SE Vaccine Trial in Healthy Adult Volunteers Active, not recruiting NCT03302897 Phase 1
31 Montelukast in ENL Reaction Unknown status NCT00406861 montelukast in treatment of ENL reaction
32 Microcirculatory Impairment in Patients With Leprosy Completed NCT02085317 acetylcholine Iontophoresis;sodium nitroprusside Iontophoresis
33 Molecular Epidemiology of Leprosy - Philippines Completed NCT00315809
34 The Use of Low Level Laser Therapy for Wound Healing in Leprosy Patients Completed NCT00860717
35 Molecular and Immunological Tools for Detection of Strain Diversity, Drug Resistance and Immunological Responses Completed NCT00138437
36 Impact of the Virtual Human Project on Team-based Learning: A Randomized-controlled Trial Completed NCT02484469
37 SMF to Improve Performance of Microscopy for the Diagnosis of PTB in a High HIV Prevalence Setting Completed NCT02701439
38 CD8 Reactivity to Microorganisms in Blood and Breast Milk Completed NCT03084614
39 γ-irradiated BCG to Train Innate Immunity Completed NCT02259608
40 Granuloma Annulare Treated With Rifampin, Ofloxacin, and Minocycline Combination Therapy Completed NCT00720980
41 Genetics of Hepatitis C Virus Infection Completed NCT00005657
42 Toll-like Receptor 2 Gene Polymorphism, Serum Cytokines and Susceptibility to Disease Severity or Treatment Response of Pulmonary Tuberculosis Completed NCT00772408
43 Efficacy of Topical Liposomal Form of Drugs in Cutaneous Leishmaniasis Completed NCT01050777 Early Phase 1 Liposomal meglumine antimoniate (Glucantime);Liposomal meglumine antimoniate;Liposomal Paromomycin;Placebo
44 Self-verification and Support Via Mobile Phones Drastically Improves Tuberculosis Treatment Success in LMIC Settings Completed NCT03135366
45 Low Level Laser Therapy Effects in Peripheral Nerves Patient With Leprosy. Recruiting NCT03072004
46 Extramembranous and Interosseous Technique of Tibialis Posterior Tendon Transfer Recruiting NCT01751503
47 Platelet Rich Plasma and Perineural Injection Therapy for Carpal Tunnel Syndrome Recruiting NCT02696161
48 Treatment Protocol for Clofazamine in the Long Term Treatment of Leprosy No longer available NCT00852345 clofazamine
49 Safety and Efficacy of Different Onset Times of Treatment With Pulsed Dye Laser on Improvement of Surgical Scars Terminated NCT00506363
50 Safety and Efficacy of Different Intervals of Pulsed Dye Laser Sessions on Improvement of Surgical Scars Withdrawn NCT00506090

Search NIH Clinical Center for Hansen's Disease

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Genetic Tests for Hansen's Disease

Anatomical Context for Hansen's Disease

MalaCards organs/tissues related to Hansen's Disease:

38
Skin, Eye, Testes, Lung, Prostate, Breast, Bone

Publications for Hansen's Disease

Articles related to Hansen's Disease:

(show top 50) (show all 324)
# Title Authors Year
1
Multiple cranial nerve palsies secondary to a recurrence of Hansen's disease. ( 29330278 )
2018
2
Hansen's Disease and Rheumatoid Arthritis Crossover of Clinical Symptoms: A Case Series of 18 Patients in the United States. ( 29141716 )
2017
3
A unique case of concomitant intra and extracranial Hansen's disease. ( 27830326 )
2017
4
Hansen's disease: An unusual presentation. ( 29417030 )
2017
5
New perspectives for the treatment of Hansen's disease. ( 29364429 )
2017
6
Spared white islands in a drug rash: revisiting sparing phenomenon in Hansen's disease. ( 28194775 )
2017
7
Neurolymphomatosis in Primary Cutaneous CD4+ Pleomorphic Small/Medium-sized T-cell Lymphoma Mimicking Hansen's Disease. ( 28584377 )
2017
8
AA synopsis of the history of Hansen's disease. ( 28801812 )
2017
9
A Modern History of 'Imperial Medicine' Surrounding Hansen's Disease: Strategies to Manage Public Opinion in Modern Japanese Media. ( 29311533 )
2017
10
Evaluation of polymerase chain reaction in nerve biopsy specimens of patients with Hansen's disease. ( 28870564 )
2017
11
Autologous Platelet-rich Fibrin Matrix in Non-healing Trophic Ulcers in Patients with Hansen's Disease. ( 28529413 )
2017
12
Oral history and memories of Hansen's disease patients in two Colombian leper colonies: life trajectories, conflicts and resistance strategies. ( 29412276 )
2017
13
Dapsone-induced agranulocytosis in patients with Hansen's disease. ( 29364462 )
2017
14
Guillain-BarrAc syndrome: A rare manifestation of Hansen's disease. ( 28084267 )
2017
15
Evaluation and Monitoring of Mycobacterium leprae Transmission in Household Contacts of Patients with Hansen's Disease in Colombia. ( 28114411 )
2017
16
The Exile of Hansen's Disease Patients to Moloka'i: A Diffusion of Innovations Perspective. ( 27105179 )
2016
17
Hansen's disease in association with immune reconstitution inflammatory syndrome. ( 26955584 )
2016
18
Nerve abscess in Hansen's disease as part of immune reconstitution inflammatory syndrome: a case report. ( 27270897 )
2016
19
A rare form of Hansen's disease presenting as filiform verrucous papules on the feet. ( 27051844 )
2016
20
Utility of Bacillary Index in Slit Skin Smears in Correlation with Clinical and Histopathological Alterations in Hansen's Disease: An Attempt to Revive a Simple Useful Procedure. ( 27398251 )
2016
21
Hansen's disease: Descriptions of novel ultrasonographic findings. ( 26827252 )
2016
22
Delayed Diagnosis, Leprosy Reactions, and Nerve Injury Among Individuals With Hansen's Disease Seen at a United States Clinic. ( 27186586 )
2016
23
Perception of social exclusion, neuropathy, and quality of life among Hansen's disease patients. ( 25930737 )
2015
24
Indigenous Cases of Leprosy (Hansen's Disease) in Southern Mississippi. ( 26434167 )
2015
25
Sensory cutaneous nerve fine-needle aspiration in Hansen's disease: A retrospective analysis of our experience. ( 26729977 )
2015
26
Primary Neuritic Hansen's Disease presenting as Ulnar Nerve Abscess in a Human Immunodeficiency Virus Positive Patient. ( 26999990 )
2015
27
Hansen's disease in the state of Amazonas: policy and institutional treatment of a disease. ( 26625914 )
2015
28
Sleep, Hansen's disease and the immune system - A not so harmonic triad. ( 25686506 )
2015
29
Isolated case of mucosal histoid Hansen's disease of the nasal cavity in a post-global elimination era. ( 26096583 )
2015
30
Family Health Strategy professionals' view on the effects of Hansen's disease training. ( 26353098 )
2015
31
Complex Type 2 Reactions in Three Patients with Hansen's Disease from a Southern United States Clinic. ( 26304919 )
2015
32
A case of 'de novo' Histoid Hansen's disease. ( 26265871 )
2015
33
Study of 35 Cases of Hansen's Disease, which Required Treatment beyond Fixed Duration--Multi Drug Therapy. ( 27506005 )
2015
34
Hansen's disease and HIV coinfection with facial nerve palsy. ( 25883486 )
2015
35
Isolated superficial peroneal neuropathy: a rare presentation of Hansen's disease (Leprosy). ( 24939189 )
2014
36
Hansen's disease associated with erythromelalgia mimicking Lupus erythematosus. ( 24616859 )
2014
37
Epidermotropism of lepra bacilli in a patient with histoid Hansen's disease. ( 25396142 )
2014
38
Tinea Barbae: In Released from Treatment (RFT) Hansen's Disease Patient. ( 25177622 )
2014
39
Correlation of Clinico-pathological Classification of Hansen's Disease in a South Indian City. ( 26411247 )
2014
40
Incidence of Hansen's Disease - United States, 1994-2011. ( 25356604 )
2014
41
Hypnotherapy: A Useful Adjunctive Therapeutic Modality in Hansen's Disease. ( 24700936 )
2014
42
Examining ERBB2 as a candidate gene for susceptibility to leprosy (Hansen's disease) in Brazil. ( 24676663 )
2014
43
Comparative role of 20% cord blood serum and 20% autologous serum in dry eye associated with Hansen's disease: a tear proteomic study. ( 25138758 )
2014
44
Huge Benign Ovarian Cystic Teratoma in a Patient with a History of Hansen's Disease. ( 25210635 )
2014
45
Periodontal findings in patients with Hansen's disease. ( 25312102 )
2014
46
Fatal Klebsiella pneumoniae meningitis in a patient with diabetes mellitus and Hansen's disease. ( 24739855 )
2014
47
Recurrence of strongyloides stercoralis infection in a patient with Hansen's disease: a case report. ( 24974444 )
2014
48
Co-morbid infections in Hansen's disease patients in the United States: considerations for treatment. ( 23980128 )
2013
49
Active surveillance of Hansen's Disease (leprosy): importance for case finding among extra-domiciliary contacts. ( 23516645 )
2013
50
Hansen's disease manifesting as acute distal symmetric microvasculitic polyneuropathy. ( 23886834 )
2013

Variations for Hansen's Disease

Expression for Hansen's Disease

Search GEO for disease gene expression data for Hansen's Disease.

Pathways for Hansen's Disease

GO Terms for Hansen's Disease

Sources for Hansen's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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