MCID: HNS001
MIFTS: 30

Hansen's Disease malady

Categories: Rare diseases

Aliases & Classifications for Hansen's Disease

Aliases & Descriptions for Hansen's Disease:

Name: Hansen's Disease 50 3 3
Leprosy 50 69

Classifications:



Summaries for Hansen's Disease

NIH Rare Diseases : 50 hansen's disease (also known as leprosy) is a rare bacterial infection that affects the skin, nerves and mucous membranes. after exposure, it may take anywhere from 2 to 10 years to develop features of the condition. once present, common signs and symptoms include skin lesions; muscle weakness or paralysis; eye problems that may lead to blindness; nosebleeds; severe pain; and/or numbness in the hands, feet, arms and legs. hansen's disease is caused by the bacterium mycobacterium leprae; however, the way in which the bacterium is transmitted (spread) is poorly understood. it appears that only about 5% of people are susceptible to the condition. hansen's disease is easily treated with combination antibiotics for 6 months to 2 years. last updated: 4/26/2015

MalaCards based summary : Hansen's Disease, also known as leprosy, is related to leprosy and lepromatous leprosy. An important gene associated with Hansen's Disease is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2). The drugs Aspirin and Rifampin have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes.

Related Diseases for Hansen's Disease

Diseases related to Hansen's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 221)
id Related Disease Score Top Affiliating Genes
1 leprosy 12.5
2 lepromatous leprosy 12.4
3 tuberculoid leprosy 12.4
4 borderline leprosy 12.4
5 indeterminate leprosy 12.3
6 leprosy 5 12.0
7 leprosy 4 11.8
8 trigeminal trophic syndrome 11.1
9 chronic rhinitis 11.1
10 mycobacterium kansasii 10.7
11 buruli ulcer 10.7
12 colobomatous microphthalmia 10.7
13 tuberculosis 10.1
14 lagophthalmos 10.0
15 neuropathy 10.0
16 foot drop 10.0
17 hepatitis 9.9
18 neuritis 9.9
19 leishmaniasis 9.9
20 syphilis 9.8
21 pulmonary tuberculosis 9.8
22 molluscum contagiosum 9.8
23 lymphoma 9.8
24 amyloidosis 9.8
25 glomerulonephritis 9.8
26 lupus erythematosus 9.8
27 systemic lupus erythematosus 9.7
28 thrombosis 9.7
29 malaria 9.7
30 arthritis 9.7
31 tetanus 9.7
32 chromoblastomycosis 9.7
33 hepatitis b 9.7
34 secondary syphilis 9.7
35 mycosis fungoides 9.7
36 psoriasis 9.7
37 dysautonomia 9.7
38 scabies 9.7
39 iridocyclitis 9.7
40 hereditary sensory neuropathy 9.6
41 filariasis 9.6
42 dermatitis 9.6
43 epidermodysplasia verruciformis 9.6
44 antiphospholipid syndrome 9.6
45 mononeuritis multiplex 9.6
46 polyneuropathy 9.6
47 hepatitis c 9.6
48 sinusitis 9.6
49 ulnar neuropathy 9.6
50 crohn's disease 9.6

Graphical network of the top 20 diseases related to Hansen's Disease:



Diseases related to Hansen's Disease

Symptoms & Phenotypes for Hansen's Disease

Drugs & Therapeutics for Hansen's Disease

Drugs for Hansen's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 422)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
2
Rifampin Approved Phase 4,Phase 2,Phase 3,Phase 1 13292-46-1 5458213 5381226
3
Acetylcholine Approved Phase 4 51-84-3 187
4
Adalimumab Approved Phase 4 331731-18-1 16219006
5
Infliximab Approved Phase 4 170277-31-3
6
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 22916-47-8 4189
7
Lidocaine Approved, Vet_approved Phase 4,Phase 3 137-58-6 3676
8
Vancomycin Approved Phase 4 1404-90-6 441141 14969
9
Cloxacillin Approved, Vet_approved Phase 4 61-72-3 6098
10
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
11
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
12
Lopinavir Approved Phase 4 192725-17-0 92727
13
Zidovudine Approved Phase 4 30516-87-1 35370
14
Mycophenolic acid Approved Phase 4 24280-93-1 446541
15
Mycophenolate mofetil Approved, Investigational Phase 4 128794-94-5 5281078
16
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
17
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
18
Ciprofloxacin Approved, Investigational Phase 4 85721-33-1 2764
19
Lamivudine Approved, Investigational Phase 4 134678-17-4 60825
20
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
21
Formaldehyde Approved, Vet_approved Phase 4 50-00-0 712
22
Abacavir Approved, Investigational Phase 4 136470-78-5 65140 441300
23
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 50-24-8 5755
24
Isoniazid Approved Phase 4,Phase 3,Phase 1 54-85-3 3767
25
Azithromycin Approved Phase 4 83905-01-5 55185 53477736 447043
26
Citalopram Approved Phase 4 59729-33-8 2771
27
Everolimus Approved Phase 4,Phase 2 159351-69-6 6442177
28
Dapsone Approved, Investigational Phase 4,Phase 1,Phase 2 80-08-0 2955
29
Foscarnet Approved Phase 4 63585-09-1, 4428-95-9 3415
30
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
31
Clofazimine Approved, Investigational Phase 4,Phase 1,Phase 2 2030-63-9 2794
32
Tazobactam Approved Phase 4 89786-04-9 123630
33
Piperacillin Approved Phase 4 66258-76-2 43672
34
Colistin Approved Phase 4 1264-72-8, 1066-17-7 5311054
35
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
36
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3 83-43-2 6741
37
Sirolimus Approved, Investigational Phase 4,Phase 2 53123-88-9 5284616 6436030 46835353
38
Altretamine Approved Phase 4 645-05-6 2123
39
Sorbitol Approved Phase 4 50-70-4 5780
40
Octreotide Approved, Investigational Phase 4 83150-76-9 383414 6400441
41
Timolol Approved Phase 4 26839-75-8 33624 5478
42
Rivaroxaban Approved Phase 4 366789-02-8
43
Cycloserine Approved Phase 4 68-41-7 401 6234
44
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
45
leucovorin Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1 58-05-9 54575, 6560146 143
46
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 59-30-3 6037
47
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 2 67-97-0 6221 10883523 5280795
48
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2 50-14-6 5280793
49
Phosphonoacetic Acid Experimental Phase 4 4408-78-0 546
50 methicillin Phase 4

Interventional clinical trials:

(show top 50) (show all 350)
id Name Status NCT ID Phase
1 Botox for Neurogenic Detrusor Overactivity and the Prevention of Autonomic Dysreflexia Following SCI Unknown status NCT02298660 Phase 4
2 Comparing a Nucleoside-Analogue-Sparing Regimen and a Protease-Inhibitor-Sparing Regimen in HIV Infected Patients Unknown status NCT00135460 Phase 4
3 Comparing Clinical Outcome of 2 Different Total Knee Prostheses: Nexgen LPS-Flex Versus AGC Unknown status NCT00294528 Phase 4
4 Rifampin Combination Therapy Versus Monotherapy in Early Staphylococcal Infections After Total Hip and Knee Arthroplasty Unknown status NCT00423982 Phase 4
5 Comparison of Adalimumab and Infliximab Treatment of Rheumatoid Arthritis Unknown status NCT00216177 Phase 4
6 The Effect of a Diet Based on Low Sodium and Slowly Absorbed Carbohydrates on the Incidence of Refeeding Syndrome in Patients With Head and Neck Cancer Unknown status NCT01845922 Phase 4
7 Effect of Additional Clofazimine on Erythema Nodosum Leprosum (ENL) Reactions in Leprosy Completed NCT01290744 Phase 4
8 Uniform Multidrug Therapy Regimen for Leprosy Patients Completed NCT00669643 Phase 4
9 Effect of Weight and/or Obesity on Dapsone Drug Concentrations Completed NCT01165840 Phase 4
10 Feasibility and Effectiveness of Community Based Isoniazid Preventive Therapy in Kenya Completed NCT00850915 Phase 4
11 Pharmacokinetics of Piperacillin, Given as Continuous Infusion to Patients With Cystic Fibrosis Completed NCT01983787 Phase 4
12 How Does Magnesium Status Influence Calcium Homeostasis? Completed NCT01593501 Phase 4
13 Bifidobacterium Lactis BB12 and Xylitol Delivered With a Novel Slow-release Pacifier Completed NCT00638677 Phase 4
14 Dysphagia in Elderly Medical Patients Completed NCT01006330 Phase 4
15 Bridging Study for Killed Oral Cholera Vaccine in Ethiopia Completed NCT01524640 Phase 4
16 Pilot Study on the Use of Sirolimus to Treat Chronic Allograft Nephropathy in Children After Kidney Transplant Completed NCT00188955 Phase 4
17 Aiming for Remission in Rheumatoid Arthritis (RA) - the ARCTIC Trial Completed NCT01205854 Phase 4
18 Do Aromatase Inhibitors (AIs) Decrease Intestinal Calcium Absorption? Completed NCT00766532 Phase 4
19 Scandinavian Cystic Fibrosis Azithromycin Study Completed NCT00411736 Phase 4
20 HUmira in Psoriatic Arthritis Completed NCT01465438 Phase 4
21 Switching From Zidovudine to an NNRTI or Lopinavir/Ritonavir in Patients Treated With Zidovudine/ Lamivudine/Abacavir. Completed NCT00139178 Phase 4
22 Long-Term Safety of Bimatoprost Ophthalmic Solution in Patients With Glaucoma or Ocular Hypertension Completed NCT01298700 Phase 4
23 Does Treatment of Hypovitaminosis D Increase Calcium Absorption? Completed NCT00581828 Phase 4
24 Weightbearing After High Tibial Osteotomy Completed NCT00426907 Phase 4
25 Proximal Tibial Open Wedge Osteotomy. A Clinical Prospective, Randomized RSA-trial. Completed NCT00319280 Phase 4
26 A Study Of Celecoxib Versus Diclofenac In Patients With Ankylosing Spondylitis Completed NCT02528201 Phase 4
27 Treatment of Vitamin D Insufficiency Completed NCT00933244 Phase 4
28 Mycophenolate vs Azathioprin in Autoimmune Hepatitis Completed NCT00687180 Phase 4
29 Cavotricuspid Isthmusblock and Circumferential Pulmonary Vein Isolation in Patients With Atrial Fibrillation Completed NCT00247780 Phase 4
30 A Multicenter Study of Oral Versus Intravenous Hydration in AIDS Patients With CMV Retinitis Treated With Foscavir (Foscarnet Sodium) Completed NCT00002125 Phase 4
31 Does Omeprazole Decrease Intestinal Calcium Absorption? Completed NCT00582972 Phase 4
32 The Effect of Low-Dose Human Growth Hormone Therapy in HIV Infected Patients Completed NCT00119769 Phase 4
33 Effect of Tadalafil (Cialis) on the Cardiovascular System of Spinal Cord Injury (SCI) Males Completed NCT01067391 Phase 4
34 Vasoactive Hormones During the Night in Patients With Obstructive Sleep Apnea and Healthy Controls. Completed NCT00291993 Phase 4
35 Analgesic Effect of Escitalopram in Total Knee Arthroplasty (TKA) Completed NCT01430520 Phase 4
36 Analgesic Effect of Gabapentin in Total Knee Arthroplasty (TKA) Completed NCT01507363 Phase 4
37 Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome Recruiting NCT02550080 Phase 4
38 COPD Online Rehabilitation (CORe) Recruiting NCT02667171 Phase 4
39 Assessing Withdrawal of Disease-Modifying Antirheumatic Drugs in Rheumatoid Arthritis Recruiting NCT01881308 Phase 4
40 Translational Approach to the Understanding and Treatment of Obsessive-Compulsive Disorder (OCD). Can D-Cycloserine Enhance and Stabilize the Treatment-response in Relapsed and Non-responding OCD-patients? Recruiting NCT02656342 Phase 4
41 Improvement of Implant Survival in Total Joint Arthroplasty of the Trapeziometacarpal Joint Recruiting NCT01554748 Phase 4
42 Safety of GANFORT® Ophthalmic Solution in Chinese Patients With Open-angle Glaucoma or Ocular Hypertension Recruiting NCT02571712 Phase 4
43 Rivaroxaban or Aspirin for Biological Aortic Prosthesis Recruiting NCT02974920 Phase 4
44 Everolimus Roll-over Protocol for Patients Who Have Completed a Previous Novartis-sponsored Everolimus Study. Recruiting NCT01789281 Phase 4
45 The NOR-SWITCH Study Active, not recruiting NCT02148640 Phase 4
46 GON-block in Chronic Migraine: a Randomized, Double- Blind, Placebo-controlled Study Not yet recruiting NCT02686983 Phase 4
47 The COOPerative Establishment for Necessary Investigation in Clinical Outcome After Stenting Not yet recruiting NCT01534221 Phase 4
48 Catheter Ablation of Atrial Fibrillation Using Hansen Medical Robotic Navigation Terminated NCT01037296 Phase 4
49 Efficacy, Safety and Efficiency Study of CARTO® 3 System Guided THERMOCOOL® Catheter Ablation Versus Fluoroscopy Guided Ablation With the Pulmonary Vein Ablation Catheter® (PVAC®) Terminated NCT01116557 Phase 4
50 Minocycline Therapy for Lung Scarring in Patients With Idiopathic Pulmonary Fibrosis - a Pilot Study Unknown status NCT00203697 Phase 3

Search NIH Clinical Center for Hansen's Disease

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Hansen's Disease

Anatomical Context for Hansen's Disease

MalaCards organs/tissues related to Hansen's Disease:

39
Skin, Eye, Testes, Heart, Bone, T Cells, Prostate

Publications for Hansen's Disease

Articles related to Hansen's Disease:

(show top 50) (show all 311)
id Title Authors Year
1
A unique case of concomitant intra and extracranial Hansen's disease. ( 27830326 )
2017
2
Guillain-BarrAc syndrome: A rare manifestation of Hansen's disease. ( 28084267 )
2017
3
The Exile of Hansen's Disease Patients to Moloka'i: A Diffusion of Innovations Perspective. ( 27105179 )
2016
4
A rare form of Hansen's disease presenting as filiform verrucous papules on the feet. ( 27051844 )
2016
5
Hansen's disease: Descriptions of novel ultrasonographic findings. ( 26827252 )
2016
6
Utility of Bacillary Index in Slit Skin Smears in Correlation with Clinical and Histopathological Alterations in Hansen's Disease: An Attempt to Revive a Simple Useful Procedure. ( 27398251 )
2016
7
Hansen's disease in association with immune reconstitution inflammatory syndrome. ( 26955584 )
2016
8
Delayed Diagnosis, Leprosy Reactions, and Nerve Injury Among Individuals With Hansen's Disease Seen at a United States Clinic. ( 27186586 )
2016
9
Nerve abscess in Hansen's disease as part of immune reconstitution inflammatory syndrome: a case report. ( 27270897 )
2016
10
Hansen's disease in the state of Amazonas: policy and institutional treatment of a disease. ( 26625914 )
2015
11
Primary Neuritic Hansen's Disease presenting as Ulnar Nerve Abscess in a Human Immunodeficiency Virus Positive Patient. ( 26999990 )
2015
12
Complex Type 2 Reactions in Three Patients with Hansen's Disease from a Southern United States Clinic. ( 26304919 )
2015
13
A case of 'de novo' Histoid Hansen's disease. ( 26265871 )
2015
14
Perception of social exclusion, neuropathy, and quality of life among Hansen's disease patients. ( 25930737 )
2015
15
Hansen's disease and HIV coinfection with facial nerve palsy. ( 25883486 )
2015
16
Sensory cutaneous nerve fine-needle aspiration in Hansen's disease: A retrospective analysis of our experience. ( 26729977 )
2015
17
Isolated case of mucosal histoid Hansen's disease of the nasal cavity in a post-global elimination era. ( 26096583 )
2015
18
Sleep, Hansen's disease and the immune system - A not so harmonic triad. ( 25686506 )
2015
19
Family Health Strategy professionals' view on the effects of Hansen's disease training. ( 26353098 )
2015
20
Indigenous Cases of Leprosy (Hansen's Disease) in Southern Mississippi. ( 26434167 )
2015
21
Study of 35 Cases of Hansen's Disease, which Required Treatment beyond Fixed Duration--Multi Drug Therapy. ( 27506005 )
2015
22
Huge Benign Ovarian Cystic Teratoma in a Patient with a History of Hansen's Disease. ( 25210635 )
2014
23
Hansen's disease associated with erythromelalgia mimicking Lupus erythematosus. ( 24616859 )
2014
24
Fatal Klebsiella pneumoniae meningitis in a patient with diabetes mellitus and Hansen's disease. ( 24739855 )
2014
25
Isolated superficial peroneal neuropathy: a rare presentation of Hansen's disease (Leprosy). ( 24939189 )
2014
26
Hypnotherapy: A Useful Adjunctive Therapeutic Modality in Hansen's Disease. ( 24700936 )
2014
27
Comparative role of 20% cord blood serum and 20% autologous serum in dry eye associated with Hansen's disease: a tear proteomic study. ( 25138758 )
2014
28
Examining ERBB2 as a candidate gene for susceptibility to leprosy (Hansen's disease) in Brazil. ( 24676663 )
2014
29
Incidence of Hansen's Disease - United States, 1994-2011. ( 25356604 )
2014
30
Tinea Barbae: In Released from Treatment (RFT) Hansen's Disease Patient. ( 25177622 )
2014
31
Recurrence of strongyloides stercoralis infection in a patient with Hansen's disease: a case report. ( 24974444 )
2014
32
Periodontal findings in patients with Hansen's disease. ( 25312102 )
2014
33
Epidermotropism of lepra bacilli in a patient with histoid Hansen's disease. ( 25396142 )
2014
34
Correlation of Clinico-pathological Classification of Hansen's Disease in a South Indian City. ( 26411247 )
2014
35
Active surveillance of Hansen's Disease (leprosy): importance for case finding among extra-domiciliary contacts. ( 23516645 )
2013
36
Anterior segment optical coherence tomography findings of iris granulomas in Hansen's disease: a case report. ( 23514098 )
2013
37
Oral myiasis in an adult associated with filariasis and Hansen's disease. ( 23633879 )
2013
38
Co-morbid infections in Hansen's disease patients in the United States: considerations for treatment. ( 23980128 )
2013
39
Hansen's disease presenting with penile nodules. ( 23557622 )
2013
40
Hansen's disease manifesting as acute distal symmetric microvasculitic polyneuropathy. ( 23886834 )
2013
41
Supraorbital nerve entrapment neuropathy in Hansen's disease. ( 23856804 )
2013
42
Atypical Hansen's disease presenting as florid verrucous plaques on the lower extremities: a case report. ( 22607288 )
2012
43
Hansen's disease: a vanishing disease? ( 23283447 )
2012
44
Various faces of Hansen's disease. ( 23236704 )
2012
45
Psychosocial aspects of Hansen's disease (leprosy). ( 23189247 )
2012
46
Degree of disability, pain levels, muscle strength, and electromyographic function in patients with Hansen's disease with common peroneal nerve damage. ( 22760139 )
2012
47
Hansen's disease (Leprosy): current and future pharmacotherapy and treatment of disease-related immunologic reactions. ( 22392826 )
2012
48
Hansen's disease: the need for increased healthcare provider awareness and re-training. ( 23304951 )
2012
49
Hansen's disease with McCune-Albright syndrome. ( 23326081 )
2012
50
Multiple giant nerve abscesses presenting like lipoma in a treated patient of Hansen's disease. ( 22715828 )
2012

Variations for Hansen's Disease

Expression for Hansen's Disease

Search GEO for disease gene expression data for Hansen's Disease.

Pathways for Hansen's Disease

GO Terms for Hansen's Disease

Sources for Hansen's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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