MCID: HNS001
MIFTS: 29

Hansen's Disease

Categories: Rare diseases

Aliases & Classifications for Hansen's Disease

MalaCards integrated aliases for Hansen's Disease:

Name: Hansen's Disease 50 3 3
Leprosy 50 69

Classifications:



Summaries for Hansen's Disease

NIH Rare Diseases : 50 hansen's disease (also known as leprosy) is a rare bacterial infection that affects the skin, nerves and mucous membranes. after exposure, it may take anywhere from 2 to 10 years to develop features of the condition. once present, common signs and symptoms include skin lesions; muscle weakness or paralysis; eye problems that may lead to blindness; nosebleeds; severe pain; and/or numbness in the hands, feet, arms and legs. hansen's disease is caused by the bacterium mycobacterium leprae; however, the way in which the bacterium is transmitted (spread) is poorly understood. it appears that only about 5% of people are susceptible to the condition. hansen's disease is easily treated with combination antibiotics for 6 months to 2 years. last updated: 4/26/2015

MalaCards based summary : Hansen's Disease, also known as leprosy, is related to leprosy and lepromatous leprosy. An important gene associated with Hansen's Disease is ERBB2 (Erb-B2 Receptor Tyrosine Kinase 2). The drugs Clofazimine and Dapsone have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and testes.

Related Diseases for Hansen's Disease

Diseases related to Hansen's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 223)
id Related Disease Score Top Affiliating Genes
1 leprosy 12.5
2 lepromatous leprosy 12.4
3 tuberculoid leprosy 12.4
4 borderline leprosy 12.3
5 indeterminate leprosy 12.3
6 leprosy 5 12.0
7 leprosy 6 11.9
8 leprosy 4 11.8
9 chronic rhinitis 11.1
10 trigeminal trophic syndrome 11.1
11 buruli ulcer 10.7
12 fetal thalidomide syndrome 10.7
13 mycobacterium kansasii 10.7
14 colobomatous microphthalmia 10.7
15 tuberculosis 10.1
16 lagophthalmos 10.0
17 neuropathy 10.0
18 foot drop 10.0
19 hepatitis 9.9
20 neuritis 9.9
21 leishmaniasis 9.9
22 syphilis 9.9
23 pulmonary tuberculosis 9.8
24 molluscum contagiosum 9.8
25 glomerulonephritis 9.8
26 lymphoma 9.8
27 lupus erythematosus 9.8
28 amyloidosis 9.8
29 systemic lupus erythematosus 9.8
30 malaria 9.7
31 arthritis 9.7
32 thrombosis 9.7
33 tetanus 9.7
34 chromoblastomycosis 9.7
35 mycosis fungoides 9.7
36 hepatitis b 9.7
37 secondary syphilis 9.7
38 scabies 9.7
39 psoriasis 9.7
40 iridocyclitis 9.7
41 dysautonomia 9.7
42 epidermodysplasia verruciformis 9.6
43 crohn's disease 9.6
44 cutaneous leishmaniasis 9.6
45 sinusitis 9.6
46 methemoglobinemia 9.6
47 filariasis 9.6
48 polyneuropathy 9.6
49 histoplasmosis 9.6
50 mononeuritis multiplex 9.6

Graphical network of the top 20 diseases related to Hansen's Disease:



Diseases related to Hansen's Disease

Symptoms & Phenotypes for Hansen's Disease

Drugs & Therapeutics for Hansen's Disease

Drugs for Hansen's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 181)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clofazimine Approved, Investigational Phase 4,Phase 1,Phase 2 2030-63-9 2794
2
Dapsone Approved, Investigational Phase 4,Phase 1,Phase 2 80-08-0 2955
3
Rifampin Approved Phase 4,Phase 2,Phase 3,Phase 1 13292-46-1 5458213 5381226
4
Isoniazid Approved Phase 4,Phase 1 54-85-3 3767
5
Piperacillin Approved Phase 4 66258-76-2 43672
6
Tazobactam Approved Phase 4 89786-04-9 123630
7
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Phase 2 59-30-3 6037
8
leucovorin Approved, Nutraceutical Phase 4,Phase 1,Phase 2 58-05-9 143 6006
9 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
10 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
11 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1
12 Vitamins Phase 4,Phase 2,Phase 3
13 Antibiotics, Antitubercular Phase 4,Phase 2,Phase 3,Phase 1
14 Antimalarials Phase 4,Phase 1,Phase 2
15 Antiparasitic Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
16 Antiprotozoal Agents Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1
17 Antitubercular Agents Phase 4,Phase 2,Phase 3,Phase 1
18 Cytochrome P-450 CYP3A Inducers Phase 4,Phase 2,Phase 3,Phase 1
19 Folic Acid Antagonists Phase 4,Phase 1,Phase 2
20 Nucleic Acid Synthesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1
21 Vitamin B Complex Phase 4,Phase 1,Phase 2
22 Antimetabolites Phase 4,Phase 1
23 Hypolipidemic Agents Phase 4,Phase 1
24 Lipid Regulating Agents Phase 4,Phase 1
25 Folate Nutraceutical Phase 4,Phase 1,Phase 2
26 Vitamin B9 Nutraceutical Phase 4,Phase 1,Phase 2
27
Minocycline Approved, Investigational Phase 3 10118-90-8 5281021
28
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
29
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3 22916-47-8 4189
30
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
31
Aluminum sulfate Approved Phase 2, Phase 3 10043-01-3
32
Goserelin Approved Phase 3 65807-02-5 47725 5311128
33
Leuprolide Approved, Investigational Phase 3 53714-56-0 3911 657181
34
Miltefosine Approved Phase 3 58066-85-6 3600
35
Benzoyl peroxide Approved Phase 3 94-36-0 7187
36
Clindamycin Approved, Vet_approved Phase 3 18323-44-9 29029
37
Lidocaine Approved, Vet_approved Phase 3 137-58-6 3676
38
Hydrocortisone Approved, Vet_approved Phase 2, Phase 3 50-23-7 5754 657311
39
Streptomycin Approved, Vet_approved Phase 2, Phase 3,Phase 1 57-92-1 19649
40
Clarithromycin Approved Phase 2, Phase 3 81103-11-9 84029
41
Infliximab Approved Phase 3 170277-31-3
42
Menadione Approved, Nutraceutical Phase 2, Phase 3 58-27-5 4055
43
Phytonadione Approved, Nutraceutical Phase 2, Phase 3 84-80-0 4812 5284607
44 Hormone Antagonists Phase 2, Phase 3
45 Hormones Phase 2, Phase 3
46 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
47 Antiemetics Phase 2, Phase 3
48 Antifungal Agents Phase 2, Phase 3
49 Antineoplastic Agents, Hormonal Phase 2, Phase 3
50 Antirheumatic Agents Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 84)

id Name Status NCT ID Phase Drugs
1 Effect of Additional Clofazimine on Erythema Nodosum Leprosum (ENL) Reactions in Leprosy Completed NCT01290744 Phase 4 Clofazimine;Placebo
2 Uniform Multidrug Therapy Regimen for Leprosy Patients Completed NCT00669643 Phase 4 PB 6 doses - Rifampicin and Dapsone;PB 6 doses - Rifampicin, Clofazimine and Dapsone;MB 12 doses - Rifampicin, Clofazimine and Dapsone;MB 6 doses - Rifampicin, Clofazimine and Dapsone
3 Effect of Weight and/or Obesity on Dapsone Drug Concentrations Completed NCT01165840 Phase 4 Dapsone
4 Feasibility and Effectiveness of Community Based Isoniazid Preventive Therapy in Kenya Completed NCT00850915 Phase 4
5 Pharmacokinetics of Piperacillin, Given as Continuous Infusion to Patients With Cystic Fibrosis Completed NCT01983787 Phase 4
6 Clinical Utility Of Genetic Screening For HLA-B*1301, On Susceptibility To Dapsone Hypersensitivity Syndrome Recruiting NCT02550080 Phase 4 Dapsone
7 COPD Online Rehabilitation (CORe) Recruiting NCT02667171 Phase 4
8 Minocycline Therapy for Lung Scarring in Patients With Idiopathic Pulmonary Fibrosis - a Pilot Study Unknown status NCT00203697 Phase 3 minocycline
9 Ciclosporin in the Management of New Type 1 Reactions in Leprosy Completed NCT00919815 Phase 2, Phase 3 Ciclosporin;Prednisolone
10 Safety/Efficacy Trial of Killed Leishmania Vaccine in Volunteers With Positive Response to Leishmanin (LST>0) Completed NCT00429780 Phase 2, Phase 3
11 Safety/Efficacy Trial of Killed Leishmania Vaccine in Volunteers With no Response to Leishmanin Completed NCT00429715 Phase 2, Phase 3
12 Efficacy and Safety of Immunomodulator as an Adjunct Therapy in New Pulmonary Tuberculosis(Category I) Patients. Completed NCT00341328 Phase 3
13 Efficacy and Safety Study of Immunomodulator as an Adjunct Therapy in Pulmonary Tuberculosis (TB) Retreatment Patients Completed NCT00265226 Phase 3
14 Thalidomide for the Treatment of Hormone-Dependent Prostate Cancer Completed NCT00004635 Phase 3 Thalidomide;leuprolide acetate;goserelin
15 Efficacy Trial on Oral Miltefosine in Comparison With Glucantime in the Treatment of ACL Caused by L. Tropica Completed NCT00351520 Phase 3 Miltefose
16 To Compare the Efficacy and Safety of Clindamycin Phosphate 1.2% / Benzoyl Peroxide 5% Gel of CHL Versus DUAC® Gel Completed NCT02005666 Phase 3 Clindamycin Phosphate 1.2% / Benzoyl Peroxide 5% Gel;DUAC® Gel;Placebo
17 Conventional Verses Ultrasound Guided Arteria Cannulation, With and Without Local Anesthesia Completed NCT01561196 Phase 3
18 The Antidepressant Effect of Repetitive Transcranial Magnetic Stimulation (rTMS)Compared to ECT Completed NCT00299403 Phase 2, Phase 3
19 Treatment of Neuropathic Pain in Leprosy Recruiting NCT03324035 Phase 3 Amitriptyline;Placebo oral capsule;Tramadol
20 Effect of Vitamin K2 (MK7) on Cardiovascular and Bone Disease in Dialysis Patients Recruiting NCT02976246 Phase 2, Phase 3
21 WHO Drug Study for Buruli Ulcer - Comparison of SR8 and CR8 Active, not recruiting NCT01659437 Phase 2, Phase 3 Clarithromycin Extended Release;Streptomycin intramuscular injection
22 Thalidomide Versus Infliximab in New Onset Crohn's Disease With Poor Prognostic Factors Not yet recruiting NCT03221166 Phase 3 Thalidomide;Infliximab
23 The Antidepressant Effect of Right Temporal Low Frequency rTMS Compared to Sham Terminated NCT00622947 Phase 2, Phase 3
24 Nilotinib Plus Pegylated Interferon-α2b in CML Unknown status NCT01866553 Phase 2 Nilotinib;Pegylated interferon α-2b
25 Leprosy Skin Test Antigens Trial Completed NCT00128193 Phase 2
26 Ciclosporin in the Management of Steroid Resistant Type 1 Reactions in Leprosy Completed NCT00919451 Phase 2 ciclosporin
27 Ciclosporin in the Management of Chronic or Recurrent Erythema Nodosum Leprosum Completed NCT00919776 Phase 2 prednisolone;ciclosporin
28 Ciclosporin in the Management of New Erythema Nodosum Leprosum Completed NCT00919542 Phase 2 Ciclosporin;prednisolone
29 Phase II Trial of Peginterferon Alpha-2b and Thalidomide in Adults With Recurrent Gliomas Completed NCT00047879 Phase 2 Thalidomide
30 Progression of HIV-Disease Under Low Dose Corticosteroids Completed NCT01299948 Phase 2 Prednisolone
31 Virgin Coconut Oil Oral Supplementation for Leprosy Patients Withdrawn NCT01885611 Phase 1, Phase 2
32 Prevention of Disability: Proposal for a Guidance Manual for Leprosy Patients Completed NCT01006759 Phase 1
33 Leprosy Skin Test Antigens Phase 1 Completed NCT01920750 Phase 1
34 Study of the Safety and Immunogenicity of Bacille Calmette Guerin (BCG) Vaccine Completed NCT00654316 Phase 1
35 Measurement of Anti-TB Drugs in Lung Tissue From Patients Having Surgery to Treat Tuberculosis Completed NCT00816426 Phase 1 Rifampicin;Isoniazid;Pyrazinamide;Kanamycin;Moxifloxacin
36 Phase 1 LEP-F1 + GLA-SE Vaccine Trial in Healthy Adult Volunteers Recruiting NCT03302897 Phase 1
37 Hyperhidrosis in Patients With Amputations Not yet recruiting NCT03236012 Phase 1 Botulinum toxin type A
38 Montelukast in ENL Reaction Unknown status NCT00406861 montelukast in treatment of ENL reaction
39 Educational Intervention for Optimizing Adolescent Mental Health Screening and Treatment in Pediatric Residency Unknown status NCT00768352
40 Embolization Procedures in the Peripheral Vasculature Using the Magellan™ Robotic System Unknown status NCT02369692
41 Clinical Evaluation of the Serum Free Light Chain Analysis Unknown status NCT01423344
42 Molecular Epidemiology of Leprosy - Philippines Completed NCT00315809
43 Microcirculatory Impairment in Patients With Leprosy Completed NCT02085317 acetylcholine Iontophoresis;sodium nitroprusside Iontophoresis
44 The Use of Low Level Laser Therapy for Wound Healing in Leprosy Patients Completed NCT00860717
45 Molecular and Immunological Tools for Detection of Strain Diversity, Drug Resistance and Immunological Responses Completed NCT00138437
46 Impact of the Virtual Human Project on Team-based Learning: A Randomized-controlled Trial Completed NCT02484469
47 SMF to Improve Performance of Microscopy for the Diagnosis of PTB in a High HIV Prevalence Setting Completed NCT02701439
48 γ-irradiated BCG to Train Innate Immunity Completed NCT02259608
49 Granuloma Annulare Treated With Rifampin, Ofloxacin, and Minocycline Combination Therapy Completed NCT00720980
50 Genetics of Hepatitis C Virus Infection Completed NCT00005657

Search NIH Clinical Center for Hansen's Disease

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Genetic Tests for Hansen's Disease

Anatomical Context for Hansen's Disease

MalaCards organs/tissues related to Hansen's Disease:

39
Skin, Eye, Testes, Lung, Bone, Breast, Prostate

Publications for Hansen's Disease

Articles related to Hansen's Disease:

(show top 50) (show all 317)
id Title Authors Year
1
Neurolymphomatosis in Primary Cutaneous CD4+ Pleomorphic Small/Medium-sized T-cell Lymphoma Mimicking Hansen's Disease. ( 28584377 )
2017
2
Autologous Platelet-rich Fibrin Matrix in Non-healing Trophic Ulcers in Patients with Hansen's Disease. ( 28529413 )
2017
3
Guillain-BarrAc syndrome: A rare manifestation of Hansen's disease. ( 28084267 )
2017
4
Evaluation of polymerase chain reaction in nerve biopsy specimens of patients with Hansen's disease. ( 28870564 )
2017
5
Spared white islands in a drug rash: revisiting sparing phenomenon in Hansen's disease. ( 28194775 )
2017
6
A unique case of concomitant intra and extracranial Hansen's disease. ( 27830326 )
2017
7
AA synopsis of the history of Hansen's disease. ( 28801812 )
2017
8
Evaluation and Monitoring of Mycobacterium leprae Transmission in Household Contacts of Patients with Hansen's Disease in Colombia. ( 28114411 )
2017
9
Delayed Diagnosis, Leprosy Reactions, and Nerve Injury Among Individuals With Hansen's Disease Seen at a United States Clinic. ( 27186586 )
2016
10
A rare form of Hansen's disease presenting as filiform verrucous papules on the feet. ( 27051844 )
2016
11
Utility of Bacillary Index in Slit Skin Smears in Correlation with Clinical and Histopathological Alterations in Hansen's Disease: An Attempt to Revive a Simple Useful Procedure. ( 27398251 )
2016
12
Nerve abscess in Hansen's disease as part of immune reconstitution inflammatory syndrome: a case report. ( 27270897 )
2016
13
Hansen's disease: Descriptions of novel ultrasonographic findings. ( 26827252 )
2016
14
Hansen's disease in association with immune reconstitution inflammatory syndrome. ( 26955584 )
2016
15
The Exile of Hansen's Disease Patients to Moloka'i: A Diffusion of Innovations Perspective. ( 27105179 )
2016
16
Isolated case of mucosal histoid Hansen's disease of the nasal cavity in a post-global elimination era. ( 26096583 )
2015
17
Sensory cutaneous nerve fine-needle aspiration in Hansen's disease: A retrospective analysis of our experience. ( 26729977 )
2015
18
Family Health Strategy professionals' view on the effects of Hansen's disease training. ( 26353098 )
2015
19
Sleep, Hansen's disease and the immune system - A not so harmonic triad. ( 25686506 )
2015
20
Hansen's disease in the state of Amazonas: policy and institutional treatment of a disease. ( 26625914 )
2015
21
Perception of social exclusion, neuropathy, and quality of life among Hansen's disease patients. ( 25930737 )
2015
22
Complex Type 2 Reactions in Three Patients with Hansen's Disease from a Southern United States Clinic. ( 26304919 )
2015
23
Hansen's disease and HIV coinfection with facial nerve palsy. ( 25883486 )
2015
24
Study of 35 Cases of Hansen's Disease, which Required Treatment beyond Fixed Duration--Multi Drug Therapy. ( 27506005 )
2015
25
Primary Neuritic Hansen's Disease presenting as Ulnar Nerve Abscess in a Human Immunodeficiency Virus Positive Patient. ( 26999990 )
2015
26
A case of 'de novo' Histoid Hansen's disease. ( 26265871 )
2015
27
Indigenous Cases of Leprosy (Hansen's Disease) in Southern Mississippi. ( 26434167 )
2015
28
Hansen's disease associated with erythromelalgia mimicking Lupus erythematosus. ( 24616859 )
2014
29
Correlation of Clinico-pathological Classification of Hansen's Disease in a South Indian City. ( 26411247 )
2014
30
Recurrence of strongyloides stercoralis infection in a patient with Hansen's disease: a case report. ( 24974444 )
2014
31
Incidence of Hansen's Disease - United States, 1994-2011. ( 25356604 )
2014
32
Examining ERBB2 as a candidate gene for susceptibility to leprosy (Hansen's disease) in Brazil. ( 24676663 )
2014
33
Comparative role of 20% cord blood serum and 20% autologous serum in dry eye associated with Hansen's disease: a tear proteomic study. ( 25138758 )
2014
34
Huge Benign Ovarian Cystic Teratoma in a Patient with a History of Hansen's Disease. ( 25210635 )
2014
35
Fatal Klebsiella pneumoniae meningitis in a patient with diabetes mellitus and Hansen's disease. ( 24739855 )
2014
36
Periodontal findings in patients with Hansen's disease. ( 25312102 )
2014
37
Hypnotherapy: A Useful Adjunctive Therapeutic Modality in Hansen's Disease. ( 24700936 )
2014
38
Isolated superficial peroneal neuropathy: a rare presentation of Hansen's disease (Leprosy). ( 24939189 )
2014
39
Tinea Barbae: In Released from Treatment (RFT) Hansen's Disease Patient. ( 25177622 )
2014
40
Epidermotropism of lepra bacilli in a patient with histoid Hansen's disease. ( 25396142 )
2014
41
Co-morbid infections in Hansen's disease patients in the United States: considerations for treatment. ( 23980128 )
2013
42
Hansen's disease presenting with penile nodules. ( 23557622 )
2013
43
Active surveillance of Hansen's Disease (leprosy): importance for case finding among extra-domiciliary contacts. ( 23516645 )
2013
44
Anterior segment optical coherence tomography findings of iris granulomas in Hansen's disease: a case report. ( 23514098 )
2013
45
Supraorbital nerve entrapment neuropathy in Hansen's disease. ( 23856804 )
2013
46
Hansen's disease manifesting as acute distal symmetric microvasculitic polyneuropathy. ( 23886834 )
2013
47
Oral myiasis in an adult associated with filariasis and Hansen's disease. ( 23633879 )
2013
48
Atypical Hansen's disease presenting as florid verrucous plaques on the lower extremities: a case report. ( 22607288 )
2012
49
Hansen's disease: a vanishing disease? ( 23283447 )
2012
50
Hansen's disease (Leprosy): current and future pharmacotherapy and treatment of disease-related immunologic reactions. ( 22392826 )
2012

Variations for Hansen's Disease

Expression for Hansen's Disease

Search GEO for disease gene expression data for Hansen's Disease.

Pathways for Hansen's Disease

GO Terms for Hansen's Disease

Sources for Hansen's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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