MCID: HRD005
MIFTS: 29

Hard Palate Cancer

Categories: Cancer diseases

Aliases & Classifications for Hard Palate Cancer

MalaCards integrated aliases for Hard Palate Cancer:

Name: Hard Palate Cancer 12 14
Malignant Tumor of the Hard Palate 12
Malignant Neoplasm of Hard Palate 12
Malignant Tumour of Hard Palate 12
Malignant Tumor of Hard Palate 12
Hard Palate 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9149
ICD10 32 C05.0
ICD9CM 34 145.2
NCIt 46 C3528
SNOMED-CT 64 363387004 93822006
UMLS 69 C0153375

Summaries for Hard Palate Cancer

MalaCards based summary : Hard Palate Cancer, also known as malignant tumor of the hard palate, is related to cleft palate, isolated and cleft hard palate. An important gene associated with Hard Palate Cancer is SHOX2 (Short Stature Homeobox 2), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Heart Development. Affiliated tissues include testes, and related phenotypes are craniofacial and digestive/alimentary

Related Diseases for Hard Palate Cancer

Diseases related to Hard Palate Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 cleft palate, isolated 30.7 MSX1 NANS SMCP TBX22 TMEM54
2 cleft hard palate 12.4
3 necrotizing sialometaplasia 11.2
4 endosteal hyperostosis, autosomal dominant 10.8
5 torus palatinus and torus mandibularis 10.8
6 cleft palate with or without ankyloglossia, x-linked 10.8
7 microtia, hearing impairment, and cleft palate 10.8
8 cleft palate, psychomotor retardation, and distinctive facial features 10.8
9 warty dyskeratoma 10.8
10 cleft lip/palate 10.3
11 lymphoma 10.2
12 myoepithelioma 10.1
13 cleft lip 10.1
14 frontal sinusitis 10.1 NOTCH1 RHNO1
15 pleomorphic adenoma 10.0
16 adenoma 10.0
17 sinusitis 10.0
18 mucositis 10.0
19 adenocarcinoma 10.0
20 mucoepidermoid carcinoma 10.0
21 epithelial-myoepithelial carcinoma 10.0
22 polymorphous low-grade adenocarcinoma 10.0
23 rapp-hodgkin syndrome 9.9 PSPC1 TBX22
24 adenoiditis 9.9
25 sarcoma 9.9
26 melanoacanthoma 9.9
27 entropion 9.9
28 cicatricial entropion 9.9
29 chondroma 9.9
30 papilloma 9.9
31 teratoma 9.9
32 histiocytoma 9.9
33 fibrous histiocytoma 9.9
34 myoblastoma 9.9
35 cocaine abuse 9.9
36 pyogenic granuloma 9.9
37 oral cancer 9.8
38 white sponge nevus 1 9.8 KRT14 KRT4
39 lymphoma, hodgkin, classic 9.7
40 langerhans cell histiocytosis 9.7
41 lymphoma, non-hodgkin, familial 9.7
42 wegener granulomatosis 9.7
43 hemangioma 9.7
44 mantle cell lymphoma 9.7
45 osteomyelitis 9.7
46 microphthalmia 9.7
47 squamous cell carcinoma 9.7
48 melanoma 9.7
49 neurilemmoma 9.7
50 herpes zoster 9.7

Graphical network of the top 20 diseases related to Hard Palate Cancer:



Diseases related to Hard Palate Cancer

Symptoms & Phenotypes for Hard Palate Cancer

MGI Mouse Phenotypes related to Hard Palate Cancer:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.56 BARX1 FGF10 KRT14 KRT4 MSX1 NOTCH1
2 digestive/alimentary MP:0005381 9.23 BARX1 FGF10 KRT14 KRT4 MSX1 NOTCH1

Drugs & Therapeutics for Hard Palate Cancer

Search Clinical Trials , NIH Clinical Center for Hard Palate Cancer

Genetic Tests for Hard Palate Cancer

Anatomical Context for Hard Palate Cancer

MalaCards organs/tissues related to Hard Palate Cancer:

38
Testes

Publications for Hard Palate Cancer

Articles related to Hard Palate Cancer:

# Title Authors Year
1
Collagen gel droplet-embedded culture drug sensitivity testing in hard palate cancer-predicted antitumor efficacy of cetuximab: A case report. ( 28855997 )
2017
2
Incidence of oral cancer with particular reference to hard palate cancer in 1 million population in the District of Visakhapatnam. ( 1184069 )
1975

Variations for Hard Palate Cancer

Expression for Hard Palate Cancer

Search GEO for disease gene expression data for Hard Palate Cancer.

Pathways for Hard Palate Cancer

Pathways related to Hard Palate Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.92 FGF10 MSX1 NOTCH1
2 10.62 FGF10 NOTCH1

GO Terms for Hard Palate Cancer

Cellular components related to Hard Palate Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.36 AHNAK2 BARX1 FGF10 KRT14 KRT4 MSX1

Biological processes related to Hard Palate Cancer according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.99 BARX1 FGF10 MSX1 NOTCH1 SHOX2
2 negative regulation of transcription, DNA-templated GO:0045892 9.88 MSX1 NOTCH1 PSPC1 TBX22
3 heart development GO:0007507 9.77 MSX1 NOTCH1 SHOX2
4 epithelial to mesenchymal transition GO:0001837 9.58 MSX1 NOTCH1
5 positive regulation of Notch signaling pathway GO:0045747 9.57 FGF10 NOTCH1
6 spleen development GO:0048536 9.56 BARX1 FGF10
7 positive regulation of BMP signaling pathway GO:0030513 9.55 MSX1 NOTCH1
8 embryonic forelimb morphogenesis GO:0035115 9.54 MSX1 SHOX2
9 pituitary gland development GO:0021983 9.52 FGF10 MSX1
10 embryonic hindlimb morphogenesis GO:0035116 9.51 MSX1 NOTCH1
11 epidermis development GO:0008544 9.5 FGF10 KRT14 NOTCH1
12 branching morphogenesis of an epithelial tube GO:0048754 9.49 FGF10 NOTCH1
13 hair follicle morphogenesis GO:0031069 9.48 FGF10 NOTCH1
14 tissue regeneration GO:0042246 9.46 FGF10 NOTCH1
15 embryonic digestive tract morphogenesis GO:0048557 9.43 FGF10 SHOX2
16 positive regulation of Ras protein signal transduction GO:0046579 9.4 FGF10 NOTCH1
17 regulation of epithelial cell proliferation GO:0050678 9.37 FGF10 NOTCH1
18 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.26 MSX1 NOTCH1
19 cardiac atrium morphogenesis GO:0003209 9.16 NOTCH1 SHOX2
20 embryonic limb morphogenesis GO:0030326 9.13 MSX1 NOTCH1 SHOX2
21 epithelial cell differentiation GO:0030855 8.92 BARX1 FGF10 KRT14 KRT4

Molecular functions related to Hard Palate Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 9.26 BARX1 MSX1 NOTCH1 SHOX2
2 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 8.8 BARX1 MSX1 TBX22

Sources for Hard Palate Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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