MCID: HRD005
MIFTS: 32

Hard Palate Cancer

Categories: Cancer diseases, Gastrointestinal diseases

Aliases & Classifications for Hard Palate Cancer

MalaCards integrated aliases for Hard Palate Cancer:

Name: Hard Palate Cancer 12 14
Malignant Tumor of the Hard Palate 12
Malignant Neoplasm of Hard Palate 12
Malignant Tumour of Hard Palate 12
Malignant Tumor of Hard Palate 12
Hard Palate 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9149
ICD10 33 C05.0
ICD9CM 35 145.2
NCIt 47 C3528
SNOMED-CT 64 363387004 93822006
UMLS 69 C0153375

Summaries for Hard Palate Cancer

MalaCards based summary : Hard Palate Cancer, also known as malignant tumor of the hard palate, is related to cleft hard palate and cleft palate, isolated. An important gene associated with Hard Palate Cancer is SHOX2 (Short Stature Homeobox 2), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Differentiation Pathway. The drugs Amifostine and Protective Agents have been mentioned in the context of this disorder. Affiliated tissues include tongue and testes, and related phenotypes are craniofacial and digestive/alimentary

Related Diseases for Hard Palate Cancer

Diseases related to Hard Palate Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
id Related Disease Score Top Affiliating Genes
1 cleft hard palate 12.2
2 cleft palate, isolated 11.3
3 necrotizing sialometaplasia 11.1
4 cleft palate, psychomotor retardation, and distinctive facial features 10.7
5 microtia, hearing impairment, and cleft palate 10.7
6 hyperostosis, endosteal 10.7
7 cleft palate with ankyloglossia 10.7
8 warty dyskeratoma 10.7
9 cleft lip/palate 10.2
10 chronic sphenoidal sinusitis 10.1 NOTCH1 RHNO1
11 lymphoma 10.1
12 cleft lip 10.0
13 pleomorphic adenoma 10.0
14 adenoma 10.0
15 ptosis 9.9 KRT14 NOTCH1
16 sinusitis 9.9
17 mucositis 9.9
18 mucoepidermoid carcinoma 9.9
19 myoepithelial carcinoma 9.9
20 epithelial-myoepithelial carcinoma 9.9
21 hypotrichosis 7 9.9 PSPC1 TBX22
22 adenoiditis 9.8
23 sarcoma 9.8
24 melanoacanthoma 9.8
25 entropion 9.8
26 cicatricial entropion 9.8
27 chondroma 9.8
28 papilloma 9.8
29 adenocarcinoma 9.8
30 teratoma 9.8
31 histiocytoma 9.8
32 fibrous histiocytoma 9.8
33 myoblastoma 9.8
34 cocaine abuse 9.8
35 polymorphous low-grade adenocarcinoma 9.8
36 pyogenic granuloma 9.8
37 epidermolysis bullosa simplex, dowling-meara type 9.8 KRT14 KRT4
38 oral cancer 9.8
39 hodgkin lymphoma 9.7
40 kindler syndrome 9.7
41 anaplastic large cell lymphoma 9.7
42 lymphomatoid granulomatosis 9.7
43 mantle cell lymphoma 9.7
44 fibroma 9.7
45 osteomyelitis 9.7
46 microphthalmia 9.7
47 paracoccidioidomycosis 9.7
48 intraductal papilloma 9.7
49 melanotic neuroectodermal tumor 9.7
50 squamous cell carcinoma 9.7

Graphical network of the top 20 diseases related to Hard Palate Cancer:



Diseases related to Hard Palate Cancer

Symptoms & Phenotypes for Hard Palate Cancer

MGI Mouse Phenotypes related to Hard Palate Cancer:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.56 BARX1 FGF10 KRT14 KRT4 MSX1 NOTCH1
2 digestive/alimentary MP:0005381 9.23 KRT14 KRT4 MSX1 NOTCH1 SHOX2 TBX22

Drugs & Therapeutics for Hard Palate Cancer

Drugs for Hard Palate Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amifostine Approved, Investigational Phase 2 20537-88-6 2141
2 Protective Agents Phase 2
3 Radiation-Protective Agents Phase 2
4
Menthol Approved 2216-51-5 16666

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Intensity-Modulated or Proton Radiation Therapy for Sinonasal Malignancy Active, not recruiting NCT01586767 Phase 2
2 Amifostine With IMRT for Submandibular and Sublingual Salivary Sparing During Head and Neck Cancer Treatment Terminated NCT00409331 Phase 2 Amifostine
3 Oral Manifestations in Children With Cancer Recruiting NCT02662465
4 Expiratory Muscle Strength Training in Improving Bulbar Function and Quality of Life in Patients With Head and Neck Cancer Recruiting NCT03175289
5 Prosthesis Guided Speech Rehabilitation of T1/T2 Cancers of the Tongue Not yet recruiting NCT02584270

Search NIH Clinical Center for Hard Palate Cancer

Genetic Tests for Hard Palate Cancer

Anatomical Context for Hard Palate Cancer

MalaCards organs/tissues related to Hard Palate Cancer:

39
Tongue, Testes

Publications for Hard Palate Cancer

Articles related to Hard Palate Cancer:

id Title Authors Year
1
Collagen gel droplet-embedded culture drug sensitivity testing in hard palate cancer-predicted antitumor efficacy of cetuximab: A case report. ( 28855997 )
2017
2
Incidence of oral cancer with particular reference to hard palate cancer in 1 million population in the District of Visakhapatnam. ( 1184069 )
1975

Variations for Hard Palate Cancer

Expression for Hard Palate Cancer

Search GEO for disease gene expression data for Hard Palate Cancer.

Pathways for Hard Palate Cancer

Pathways related to Hard Palate Cancer according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.93 FGF10 MSX1 NOTCH1
2 10.84 FGF10 NOTCH1
3 10.62 FGF10 NOTCH1

GO Terms for Hard Palate Cancer

Cellular components related to Hard Palate Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.36 AHNAK2 BARX1 FGF10 KRT14 KRT4 MSX1

Biological processes related to Hard Palate Cancer according to GeneCards Suite gene sharing:

(show all 20)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription from RNA polymerase II promoter GO:0045944 9.97 BARX1 FGF10 MSX1 NOTCH1 SHOX2
2 negative regulation of transcription, DNA-templated GO:0045892 9.85 MSX1 NOTCH1 PSPC1 TBX22
3 heart development GO:0007507 9.77 MSX1 NOTCH1 SHOX2
4 epithelial to mesenchymal transition GO:0001837 9.58 MSX1 NOTCH1
5 spleen development GO:0048536 9.57 BARX1 FGF10
6 positive regulation of BMP signaling pathway GO:0030513 9.56 MSX1 NOTCH1
7 positive regulation of Notch signaling pathway GO:0045747 9.54 FGF10 NOTCH1
8 embryonic forelimb morphogenesis GO:0035115 9.52 MSX1 SHOX2
9 pituitary gland development GO:0021983 9.51 FGF10 MSX1
10 epidermis development GO:0008544 9.5 FGF10 KRT14 NOTCH1
11 embryonic hindlimb morphogenesis GO:0035116 9.49 MSX1 NOTCH1
12 branching morphogenesis of an epithelial tube GO:0048754 9.48 FGF10 NOTCH1
13 hair follicle morphogenesis GO:0031069 9.46 FGF10 NOTCH1
14 tissue regeneration GO:0042246 9.43 FGF10 NOTCH1
15 embryonic digestive tract morphogenesis GO:0048557 9.4 FGF10 SHOX2
16 regulation of epithelial cell proliferation GO:0050678 9.37 FGF10 NOTCH1
17 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.26 MSX1 NOTCH1
18 cardiac atrium morphogenesis GO:0003209 9.16 NOTCH1 SHOX2
19 embryonic limb morphogenesis GO:0030326 9.13 MSX1 NOTCH1 SHOX2
20 epithelial cell differentiation GO:0030855 8.92 BARX1 FGF10 KRT14 KRT4

Molecular functions related to Hard Palate Cancer according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 8.96 BARX1 MSX1
2 sequence-specific DNA binding GO:0043565 8.92 BARX1 MSX1 NOTCH1 SHOX2

Sources for Hard Palate Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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