MCID: HSH003
MIFTS: 67

Hashimoto Thyroiditis

Categories: Rare diseases, Endocrine diseases, Immune diseases

Aliases & Classifications for Hashimoto Thyroiditis

MalaCards integrated aliases for Hashimoto Thyroiditis:

Name: Hashimoto Thyroiditis 53 12 24 28 13
Autoimmune Thyroiditis 12 49 24 14 69
Chronic Lymphocytic Thyroiditis 12 49 24
Hashimoto's Thyroiditis 12 72 36
Hashimoto's Disease 12 49 24
Hashimoto Struma 53 72 24
Lymphocytic Thyroiditis 12 24
Hashimoto's Syndrome 12 49
Hashimoto Disease 24 69
Autoimmune Chronic Lymphocytic Thyroiditis 24
Chronic Lymphocytic Thyroiditides 24
Hypothyroidism, Autoimmune 53
Thyroiditis, Autoimmune 41
Hashimotos Thyroiditis 51
Thyroiditis, Chronic 49
Thyroiditis Chronic 51
Hashimoto's Struma 49
Hashimoto Syndrome 24
Ht 53

Characteristics:

OMIM:

53
Inheritance:
autosomal dominant


HPO:

31
hashimoto thyroiditis:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 53 140300
Disease Ontology 12 DOID:7188
ICD10 32 E06.3 E06.2
MeSH 41 D013967
NCIt 46 C38766
MedGen 39 C0677607
KEGG 36 H00081
SNOMED-CT via HPO 65 263681008

Summaries for Hashimoto Thyroiditis

NIH Rare Diseases : 49 Hashimoto’s syndrome is an autoimmune disease in which a person's immune system mistakenly attacks the thyroid gland, reducing its ability to produce hormones (hypothyroidism). Many people with Hashimoto’s syndrome have no symptoms at first. An early sign of the syndrome may be enlargement of the thyroid (called a goiter), which can potentially interfere with breathing or swallowing. Other signs and symptoms may include tiredness, weight gain, thin and dry hair, joint or muscle pain, constipation, cold intolerance, and/or a slowed heart rate. Women with Hashimoto's syndrome may have irregular menstrual periods or difficulty becoming pregnant. Hashimoto’s syndrome is the most common cause of hypothyroidism in the United States. It is more common in women than in men, and it usually appears in mid-adulthood. Like most autoimmune diseases, Hashimoto's syndrome is thought to result from a combination of genetic and environmental factors. Treatment is not always needed, but may include taking synthetic thyroid hormone. Last updated: 10/17/2017

MalaCards based summary : Hashimoto Thyroiditis, also known as autoimmune thyroiditis, is related to subacute lymphocytic thyroiditis and thyroiditis, and has symptoms including autoimmune antibody positivity An important gene associated with Hashimoto Thyroiditis is CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4), and among its related pathways/superpathways are Autoimmune thyroid disease and Pathways in cancer. The drugs Selenium and Glatiramer Acetate have been mentioned in the context of this disorder. Affiliated tissues include thyroid gl, thyroid and heart, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Genetics Home Reference : 24 Hashimoto thyroiditis is a condition that affects the function of the thyroid, which is a butterfly-shaped gland in the lower neck. The thyroid makes hormones that help regulate a wide variety of critical body functions. For example, thyroid hormones influence growth and development, body temperature, heart rate, menstrual cycles, and weight. Hashimoto thyroiditis is a form of chronic inflammation that can damage the thyroid, reducing its ability to produce hormones.

Disease Ontology : 12 An autoimmune disease of endocrine system that involves inflammation located in thyroid gland caused by the immune system reacting against its own tissues.

Wikipedia : 72 Hashimoto\'s thyroiditis, also known as chronic lymphocytic thyroiditis and Hashimoto\'s disease, is an... more...

Description from OMIM: 140300

Related Diseases for Hashimoto Thyroiditis

Diseases related to Hashimoto Thyroiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 190)
# Related Disease Score Top Affiliating Genes
1 subacute lymphocytic thyroiditis 34.6 TG TPO
2 thyroiditis 30.6 CALCA CTLA4 FASLG HT IFNG RET
3 hypothyroidism 30.6 SLC26A4 TG TPO TSHB TSHR
4 struma ovarii 30.5 RET TG TSHR
5 subacute thyroiditis 30.3 TG TPO TSHR
6 autoimmune hepatitis 30.2 AIRE CTLA4 FAS
7 myxedema 30.2 CTLA4 TG TPO TSHR
8 differentiated thyroid carcinoma 30.1 RET TG TPO TSHR
9 myasthenia gravis 30.1 AIRE CTLA4 IFNG IL4
10 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.1 AIRE CTLA4 IFNG PTPN22 TG TPO
11 thyroid cancer, nonmedullary, 1 30.0 CALCA KRT19 LGALS3 RET TG TPO
12 celiac disease 1 29.9 CTLA4 IFNG PTPN22 TG TPO
13 vitiligo-associated multiple autoimmune disease susceptibility 1 29.8 AIRE CTLA4 PTPN22 TPO
14 goiter 29.7 CALCA SLC26A4 TG TPO TSHR
15 rheumatoid arthritis 29.7 CTLA4 ICAM1 IFNG IL4 PTPN22
16 thyroid cancer 29.3 CALCA KRT19 LGALS3 RET SLC26A4 TG
17 systemic lupus erythematosus 29.3 CD40 CTLA4 FAS FASLG ICAM1 IFNG
18 papillary carcinoma 29.3 CALCA KRT19 LGALS3 RET TG TPO
19 graves' disease 28.3 ATP5PO CD40 CTLA4 FAS FASLG ICAM1
20 autoimmune polyendocrine syndrome, type i, with or without reversible metaphyseal dysplasia 11.3
21 autoimmune thyroid disease 3 11.2
22 autoimmune disease, multisystem, infantile-onset, 1 11.1
23 autoimmune disease 1 11.1
24 autoimmune thyroid disease 2 11.1
25 lymphomatous thyroiditis 11.0
26 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.9
27 familial thyroid dyshormonogenesis 10.7 TG TPO
28 mucoepidermoid thyroid carcinoma 10.7 CALCA TG
29 mycoplasmal pneumonia 10.6 IFNG IL4
30 hypothyroidism, congenital, nongoitrous, 4 10.6 TG TPO TSHB
31 suppurative thyroiditis 10.6 CALCA TG
32 neonatal hypothyroidism 10.6 TG TPO TSHR
33 persistent polyclonal b-cell lymphocytosis 10.6 FAS IL4
34 graves disease 1 10.6 TG TPO TSHR
35 thyroid sarcoma 10.6 CALCA TG
36 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.6 TG TPO
37 hyperlucent lung 10.6 IFNG IL4
38 ovarian germ cell teratoma 10.6 RET TG
39 plummer's disease 10.6 ICAM1 TG TPO
40 burn scar 10.6 CALCA FAS
41 type ii mixed cryoglobulinemia 10.6 FAS FASLG
42 benign struma ovarii 10.6 RET TG TSHR
43 papillary thyroid microcarcinoma 10.5 CALCA TG TSHR
44 thyroid cancer, anaplastic 10.5 RET TG
45 urinary schistosomiasis 10.5 CTLA4 IFNG IL4
46 cytomegalovirus infection 10.5 FAS ICAM1 IFNG
47 erythema multiforme 10.5 FASLG ICAM1 IFNG
48 ovarian germ cell cancer 10.5 RET TG
49 paracoccidioidomycosis 10.5 CTLA4 IFNG IL4
50 acute graft versus host disease 10.5 FASLG IFNG IL4

Graphical network of the top 20 diseases related to Hashimoto Thyroiditis:



Diseases related to Hashimoto Thyroiditis

Symptoms & Phenotypes for Hashimoto Thyroiditis

Symptoms via clinical synopsis from OMIM:

53
Immunology:
thyroid autoimmunity

Lab:
hashimoto struma
thyroid autoantibodies
abnormal, small, iodinated protein in the serum
defect in thyroid basement membrane

Endocrine:
hashimoto thyroiditis


Clinical features from OMIM:

140300

Human phenotypes related to Hashimoto Thyroiditis:

31
# Description HPO Frequency HPO Source Accession
1 hashimoto thyroiditis 31 HP:0000872
2 autoimmune antibody positivity 31 HP:0030057

MGI Mouse Phenotypes related to Hashimoto Thyroiditis:

43 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.43 IL4 ICAM1 IFNG KRT19 RET SLC26A4
2 homeostasis/metabolism MP:0005376 10.4 IL4 ICAM1 IFNG RET LGALS3 SLC26A4
3 hematopoietic system MP:0005397 10.38 IL4 ICAM1 IFNG RET LGALS3 PTPN22
4 immune system MP:0005387 10.36 IL4 ICAM1 IFNG RET LGALS3 SLC26A4
5 digestive/alimentary MP:0005381 10.35 IL4 ICAM1 IFNG KRT19 RET LGALS3
6 growth/size/body region MP:0005378 10.33 IFNG ICAM1 IL4 PTPN22 KRT19 RET
7 mortality/aging MP:0010768 10.27 IFNG FASLG ICAM1 IL4 PTPN22 KRT19
8 nervous system MP:0003631 10.22 IFNG FASLG ICAM1 IL4 KRT19 RET
9 integument MP:0010771 10.1 IFNG FASLG ICAM1 IL4 KRT19 LGALS3
10 neoplasm MP:0002006 10.09 ICAM1 IFNG KRT19 RET LGALS3 TSHR
11 liver/biliary system MP:0005370 10.08 IFNG FASLG IL4 LGALS3 PTPN22 CTLA4
12 normal MP:0002873 10.02 IFNG FASLG IL4 KRT19 RET CTLA4
13 reproductive system MP:0005389 10 FASLG IL4 IFNG KRT19 RET LGALS3
14 renal/urinary system MP:0005367 9.97 IFNG FASLG IL4 RET LGALS3 SLC26A4
15 respiratory system MP:0005388 9.81 IFNG FASLG IL4 RET LGALS3 PTPN22
16 skeleton MP:0005390 9.7 IFNG FASLG IL4 KRT19 LGALS3 SLC26A4
17 vision/eye MP:0005391 9.23 IFNG FASLG ICAM1 IL4 TPO TSHR

Drugs & Therapeutics for Hashimoto Thyroiditis

Drugs for Hashimoto Thyroiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 166)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Selenium Approved, Investigational, Vet_approved Phase 4,Phase 2 7782-49-2
2
Glatiramer Acetate Approved, Investigational Phase 4 147245-92-9 3081884
3
Labetalol Approved Phase 4 36894-69-6 3869
4
Nifedipine Approved Phase 4 21829-25-4 4485
5 Antioxidants Phase 4,Phase 2
6 Micronutrients Phase 4,Phase 2
7 Protective Agents Phase 4,Phase 2,Phase 1
8 Trace Elements Phase 4,Phase 2
9 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
10 Adjuvants, Immunologic Phase 4
11 Immunosuppressive Agents Phase 4,Phase 3,Phase 2
12 Antihypertensive Agents Phase 4
13 Calcium, Dietary Phase 4,Phase 2
14 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2
15 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
16 Epoetin alfa Phase 4 113427-24-0
17 Hematinics Phase 4
18 Adrenergic Agents Phase 4,Phase 1,Phase 2
19 Adrenergic alpha-1 Receptor Antagonists Phase 4
20 Adrenergic alpha-Antagonists Phase 4,Phase 1,Phase 2
21 Adrenergic Antagonists Phase 4,Phase 1,Phase 2
22 Adrenergic beta-Antagonists Phase 4
23 Autonomic Agents Phase 4,Phase 1
24 calcium channel blockers Phase 4
25 Tocolytic Agents Phase 4
26 Vasodilator Agents Phase 4,Phase 1,Phase 2
27
Aripiprazole Approved, Investigational Phase 3,Phase 1 129722-12-9 60795
28 Brexpiprazole Approved, Investigational Phase 3 913611-97-9 11978813
29
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
30
Ethanol Approved Phase 3 64-17-5 702
31
Naltrexone Approved, Investigational, Vet_approved Phase 3,Phase 1 16590-41-3 5360515
32
Palivizumab Approved, Investigational Phase 3 188039-54-5
33
Adalimumab Approved Phase 3,Phase 2 331731-18-1 16219006
34
Azithromycin Approved Phase 3 83905-01-5 53477736 447043 55185
35
Etanercept Approved, Investigational Phase 3 185243-69-0
36
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
37 Anti-Infective Agents Phase 3,Phase 1,Phase 2
38 Antiviral Agents Phase 3,Phase 1,Phase 2
39 Antibodies Phase 3,Phase 2,Phase 1
40 Anti-Inflammatory Agents Phase 3,Phase 2,Phase 1
41 Immunoglobulins Phase 3,Phase 2,Phase 1
42 Antipsychotic Agents Phase 3,Phase 1
43 Central Nervous System Depressants Phase 3,Phase 1
44 Dopamine Agents Phase 3
45 Dopamine agonists Phase 3
46 Psychotropic Drugs Phase 3,Phase 1
47
Serotonin Phase 3 50-67-9 5202
48 Serotonin Agents Phase 3
49 Tranquilizing Agents Phase 3,Phase 1
50
nalmefene Phase 3,Phase 1 55096-26-9 5284594

Interventional clinical trials:

(show top 50) (show all 86)

# Name Status NCT ID Phase Drugs
1 Selenium Supplementation in Youths With Autoimmune Thyroiditis Unknown status NCT02644707 Phase 4
2 Glatiramer Acetate for Multiple Sclerosis With Autoimmune Comorbidities Completed NCT01456416 Phase 4
3 Effect of Erythropoietin in Refractory Autoimmune Encephalitis Patients Recruiting NCT03004209 Phase 4 Erythropoietin
4 Chronic Hypertension and Pregnancy (CHAP) Project Recruiting NCT02299414 Phase 4 Anti-hypertensive therapy
5 Brexpiprazole (OPC-34712) Trial in the Treatment of Adults With Acute Schizophrenia Completed NCT02054702 Phase 3 Brexpiprazole;Aripiprazole
6 Monotherapy Brexpiprazole (OPC-34712) Trial in the Treatment of Adults With Early-Episode Schizophrenia Completed NCT02013622 Phase 3 Brexpiprazole
7 Brexpiprazole (OPC-34712) as an Adjunctive Treatment in Active Adults, 18 to 35 Years Old, With Major Depressive Disorder Who Are in a School or Work Environment Completed NCT02013609 Phase 3 Brexpiprazole
8 Brexpiprazole (OPC-34712) as an Adjunctive Treatment in Adults With Major Depressive Disorder and Anxiety Symptoms Completed NCT02013531 Phase 3 Brexpiprazole
9 Brexpiprazole as Adjunctive Therapy With Major Depressive Disorder and an Inadequate Response to Previous Adjunctive Therapy Completed NCT02012218 Phase 3 ADT;Brexpiprazole
10 A Multicenter, Randomized, Double-blind, Placebo-controlled, 3-parallel-group Comparison Trial to Investigate the Effect of Nalmefene on Alcohol Consumption Reduction in Patients With Alcohol Dependence (Phase 3 Trial) Completed NCT02364947 Phase 3 Nalmefene hydrochloride;Placebo
11 Clinical Study of Palivizumab in Japanese Newborns, Infants and Young Children at the Age of 24 Months or Less With Immunocompromised Medical Conditions Completed NCT01466062 Phase 3 Palivizumab
12 Safety, Efficacy, and Pharmacokinetics of Adalimumab in Japanese Children With Juvenile Rheumatoid Arthritis Completed NCT00690573 Phase 3
13 Self-injection of Adalimumab in Adult Japanese Subjects With Rheumatoid Arthritis Completed NCT00603993 Phase 3
14 A Study of Adalimumab in Adult Japanese Subjects With Rheumatoid Arthritis Completed NCT00647491 Phase 2, Phase 3
15 Adalimumab in Adult Japanese Subjects With Rheumatoid Arthritis Completed NCT00235872 Phase 3
16 A Trial Of Azithromycin SR For The Treatment Of Laryngopharyngitis or Tonsillitis or Acute Bacterial Rhinosinusitis Completed NCT00393835 Phase 3 Azithromycin SR
17 Comparison of CHS-0214 to Enbrel (Etanercept) in Patients With Rheumatoid Arthritis (RA) Completed NCT02115750 Phase 3 Etanercept;CHS-0214
18 Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids (ASTEROID 4) Recruiting NCT03400956 Phase 3 Vilaprisan (BAY1002670);Placebo
19 Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids Recruiting NCT03194646 Phase 3 Vilaprisan (BAY1002670);Vilaprisan (BAY1002670);Vilaprisan (BAY1002670);Vilaprisan (BAY1002670);Vilaprisan (BAY1002670);Vilaprisan (BAY1002670)
20 A Study to Assess the Safety and Efficacy of Vilaprisan in Japanese Subjects With Uterine Fibroids and Heavy Menstrual Bleeding Not yet recruiting NCT03476928 Phase 3 Vilaprisan (BAY1002670)
21 Brexpiprazole (OPC 34712) Trial in the Treatment of Adults With Major Depressive Disorder and Irritability Withdrawn NCT02212613 Phase 3 Brexpiprazole
22 Effect of Semet (80 and 160 mcg) Versus Placebo in Euthyroid Patients With AIT Unknown status NCT02302768 Phase 2
23 IL-2 in Refractory Autoimmune Encephalitis Unknown status NCT02714959 Phase 1, Phase 2 Proleukin
24 Low-Level Laser Therapy in Chronic Autoimmune Thyroiditis Completed NCT01129492 Phase 2
25 Evaluating the Dietary Supplement Anatabloc in Thyroid Health-ASAP (Antabloc Supplementation Autoimmune Prevention) Completed NCT01551498 Phase 2
26 An Open Study of Sulforaphane-rich Broccoli Sprout Extract in Patients With Schizophrenia Completed NCT01716858 Phase 2
27 A Phase 2 Trial of Rebamipide Liquid to Determine the Effective Dose for Prevention of Chemoradiotherapy-induced Oral Mucositis in Patients With Head and Neck Cancer Completed NCT02085460 Phase 2 Placebo;2% Rebamipide liquid;4% Rebamipide liquid
28 Adalimumab in Adult Japanese Subjects With Rheumatoid Arthritis Completed NCT00235833 Phase 2
29 The Role of Immunomodulatory Treatment in Success of ICSI in Patients With Autoimmune Thyroiditis Recruiting NCT03289403 Phase 2 Immunomodulatory;Thyroxine
30 Ifenprodil Tartrate Treatment of Adolescents With Post-traumatic Stress Disorder: a Double-blind, Placebo-controlled Trial Recruiting NCT01896388 Phase 1, Phase 2 Ifenprodil Tartrate;Placebo
31 Tipepidine in Children With Attention Deficit/Hyperactivity Disorder (AD/HD): a Double-blind, Placebo-controlled Trial Recruiting NCT02305134 Phase 1, Phase 2 Tipepidine Hibenzate;Placebo
32 Study of NAC of GA Therapy for Patients With BRPC Recruiting NCT02926183 Phase 2 Neoadjuvant chemotherapy of gemcitabine plus nab-paclitaxel
33 A Phase 2 Trial to Evaluate the Efficacy and Safety of OCV-501 in Elderly Patients With Acute Myeloid Leukemia Active, not recruiting NCT01961882 Phase 2 OCV-501;Placebo
34 Eradication of H. Pylori Therapy Individualized by the Mutation of 23S rRNA of H. Pylori Not yet recruiting NCT02761005 Phase 2 Eradication of H. pylori
35 Infections and Autoimmunity: Autobodies Screening in Multiple Sclerosis Unknown status NCT00230204 Phase 1
36 A Study of Sustained-Release Liothyronine Sodium (T3) in Healthy Subjects Completed NCT01581463 Phase 1 Liothyronine, Sodium
37 A Phase 1 Study of OCV-C02 in Patients With Advanced or Relapsed Colorectal Cancer Completed NCT01801930 Phase 1 OCV-103 and OCV-104;OCV-103 and OCV-104;OCV-103 and OCV-104;OCV-103 and OCV-104
38 A Single-center, Open-label, Single-dose Study Investigating the Safety, Tolerability, and Pharmacokinetic Properties of Nalmefene 10 mg Tablets in Healthy Japanese Male Subjects Completed NCT02679469 Phase 1 nalmefene hydrochloride 10 mg
39 A Multicenter Open-label Study Investigating the Pharmacokinetics and Safety of Aripiprazole IM Depot Formulation (OPC-14597 IMD) During Repeated Administration by Injection Into the Deltoid Muscle in Patients With Schizophrenia Completed NCT02220712 Phase 1 OPC-14597 IMD
40 Pharmacodynamic Study of Cilostazol in Healthy Volunteers Recruiting NCT02554721 Phase 1 Cilostazol;Acetylsalicylic acid;Clopidogrel
41 First-in-Human Dose Escalation Study of M201-A in Healthy Japanese Subjects Recruiting NCT03055403 Phase 1 M201-A Injection;Placebo
42 Phase 1 Study of SGI-110 in Patients With Acute Myeloid Leukemia Active, not recruiting NCT02293993 Phase 1 SGI-110
43 The Effect of Plaquenil on Serum Inflammatory Markers and Goiter in Euthyroid Young Women With Hashimoto's Thyroiditis Unknown status NCT02126683 Hydroxychloroquine
44 DNA Methylation and Autoimmune Thyroid Diseases Unknown status NCT02491567
45 CXCL9 and CXCL11 Levels in Patients With Autoimmune Thyroiditis and Habitual Abortions Unknown status NCT01644318
46 The Influence of Psychobiological Adversity to Children and Adolescents With Type 1 Diabetes Unknown status NCT02575001
47 TSH And AMH in Infertile Women Unknown status NCT02710175
48 Fetuin A in Hashimoto Thyroiditis Completed NCT01884649
49 Hashimotos Thyroiditis and Thyroid Cancer Completed NCT01428167
50 The Effect of Hydroxychloroquine Treatment in Hashimoto's Thyroiditis Completed NCT01760421 Hydroxychloroquine

Search NIH Clinical Center for Hashimoto Thyroiditis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: thyroiditis, autoimmune

Genetic Tests for Hashimoto Thyroiditis

Genetic tests related to Hashimoto Thyroiditis:

# Genetic test Affiliating Genes
1 Hashimoto Thyroiditis 28 CTLA4

Anatomical Context for Hashimoto Thyroiditis

The Foundational Model of Anatomy Ontology organs/tissues related to Hashimoto Thyroiditis:

18
Thyroid Gl

MalaCards organs/tissues related to Hashimoto Thyroiditis:

38
Thyroid, Heart, Myeloid, B Cells, Bone, Tonsil, Testes

Publications for Hashimoto Thyroiditis

Articles related to Hashimoto Thyroiditis:

(show top 50) (show all 1165)
# Title Authors Year
1
The effect of vitamin D supplementation on thyroid autoantibody levels in the treatment of autoimmune thyroiditis: a systematic review and a meta-analysis. ( 29388046 )
2018
2
Neuroprotective effect of (-)-epigallocatechin-3-gallate on autoimmune thyroiditis in a rat model by an anti-inflammation effect, anti-apoptosis and inhibition of TRAIL signaling pathway. ( 29434699 )
2018
3
Atypical phenotypic aspects of autoimmune thyroid disorders in young patients with Turner syndrome. ( 29343299 )
2018
4
The immunological disease continuum of inflammation against self as an explanation for the lack of association between hidradenitis suppurativa and autoimmune thyroid disease. ( 29327479 )
2018
5
Necrobiosis lipoidica with mucin deposition in a patient with autoimmune thyroiditis. ( 29411412 )
2018
6
Ultrasound variants of autoimmune thyroiditis in children and adolescents and their clinical implication in relation to papillary thyroid carcinoma development. ( 28866751 )
2017
7
Dihydroartemisinin attenuates autoimmune thyroiditis by inhibiting the CXCR3/PI3K/AKT/NF-I_B signaling pathway. ( 29383139 )
2017
8
Concurrent Linear Immunoglobulin A Dermatosis, Hashimoto Thyroiditis, and Immunoglobulin A Nephropathy in an Adult. ( 28392654 )
2017
9
Thyroid, Hashimoto Thyroiditis ( 29083758 )
2017
10
Hashimoto thyroiditis, anti-thyroid antibodies and systemic lupus erythematosus. ( 28544477 )
2017
11
Transient Hypothyroidism and Autoimmune Thyroiditis in Children with Chronic Hepatitis C Treated with Pegylated-Interferon-I+-2b and Ribavirin. ( 28953189 )
2017
12
Frequency of nodular goiter and autoimmune thyroid disease and association of these disorders with insulin resistance in polycystic ovary syndrome. ( 28400351 )
2017
13
Genetic Risk Factors for Autoimmune Thyroid Disease might Affect the Susceptibility to and Modulate the Progression of Primary Biliary Cholangitis. ( 28922436 )
2017
14
Systemic contact dermatitis caused by cobalt chloride and palladium in a 26-year-old woman with allergic type I reactions, non-steroidal anti-inflammatory drug hypersensitivity and autoimmune thyroiditis. ( 28951718 )
2017
15
Effects of Vitamin D deficiency treatment on metabolic markers in Hashimoto thyroiditis patients. ( 28400827 )
2017
16
Protein oxidation and autoantibodies' reactivity against malondialdehyde and hydrogen peroxide-modified thyroid antigens in plasma of patients with Graves' disease and Hashimoto Thyroiditis. ( 28431875 )
2017
17
Association between C1q gene polymorphisms and autoimmune thyroid diseases. ( 28225862 )
2017
18
Flexible peptide recognition by HLA-DR triggers specific autoimmune T-cell responses in autoimmune thyroiditis and diabetes. ( 27670087 )
2017
19
Estimation of Salivary Parameters among Autoimmune Thyroiditis Patients. ( 28893031 )
2017
20
The Association of Thyrotropin and Autoimmune Thyroid Disease in Developing Papillary Thyroid Cancer. ( 28951739 )
2017
21
Polymorphisms in MIR499A and MIR125A gene are associated with autoimmune thyroid diseases. ( 27888002 )
2017
22
Association of vitamin D insufficiency/deficiency with thyroid artery Doppler ultrasonography in patients with Hashimoto thyroiditis. ( 28523025 )
2017
23
Monogenic Hashimoto thyroiditis associated with a variant in the thyroglobulin (TG) gene. ( 28942902 )
2017
24
Clinical analysis of Hashimoto thyroiditis coexistent with papillary thyroid cancer in 1392 patients. ( 29165434 )
2017
25
Pericardial Effusion as a Presenting Symptom of Hashimoto Thyroiditis: A Case Report. ( 29240719 )
2017
26
HASHIMOTO THYROIDITIS AND VESTIBULAR DYSFUNCTION. ( 28534686 )
2017
27
Reactivity to Novel Autoantigens in Patients with Coexisting Central Nervous System Demyelinating Disease and Autoimmune Thyroid Disease. ( 28533776 )
2017
28
Immunological Mechanisms Implicated in the Pathogenesis of Chronic Urticaria and Hashimoto Thyroiditis. ( 28865416 )
2017
29
A concise review of Hashimoto thyroiditis (HT) and the importance of iodine, selenium, vitamin D and gluten on the autoimmunity and dietary management of HT patients.Points that need more investigation. ( 28315909 )
2017
30
Prominent eye muscle artefact on the EEG of a patient with Hashimoto thyroiditis with primary hypothyroidism. ( 29165302 )
2017
31
HHV-6A in vitro infection of thyrocytes and T cells alters the expression of miRNA associated to autoimmune thyroiditis. ( 28081700 )
2017
32
Chloroquine Toxicity Misdiagnosed as Fabry Disease Associated with Systemic Lupus Erythematosus and Hashimoto Thyroiditis. ( 29196549 )
2017
33
Meta-analysis of the correlation between<i>Helicobacter pylori</i>infection and autoimmune thyroid diseases. ( 29383192 )
2017
34
Acoustic Radiation Force Impulse Quantification in the Evaluation of Thyroid Elasticity in Pediatric Patients With Hashimoto Thyroiditis. ( 29064111 )
2017
35
Sonographic Features of Cervical Lymph Nodes in Patients With Hashimoto Thyroiditis and the Impacts From the Levothyroxine With Prednisone Therapy. ( 29112639 )
2017
36
Autoimmune Thyroiditis Presenting as Psychosis. ( 28904513 )
2017
37
Myxedema Psychosis in a Patient With Undiagnosed Hashimoto Thyroiditis. ( 28055088 )
2017
38
Vitamin D supplementation changed relationships, not levels of metabolic-hormonal parameters in autoimmune thyroiditis. ( 28948825 )
2017
39
BRAF(V600E) mutation contributes papillary thyroid carcinoma and Hashimoto thyroiditis with resistance to thyroid hormone: A case report and literature review. ( 28928829 )
2017
40
Anti-Thyroperoxidase Antibody Levels >500a88IU/ml Indicate a Moderately Increased Risk for Developing Hypothyroidism in Autoimmune Thyroiditis. ( 27607246 )
2016
41
RANKL/Osteoprotegerin System and Bone Turnover in Hashimoto Thyroiditis. ( 27328677 )
2016
42
Potential Influence of Selenium, Copper, Zinc and Cadmium on L-Thyroxine Substitution in Patients with Hashimoto Thyroiditis and Hypothyroidism. ( 27793066 )
2016
43
Importance of Delphian Lymph Node Evaluation in Autoimmune Thyroiditis: Fact or Fiction? ( 26985243 )
2016
44
Association of autoimmune thyroid diseases, chronic atrophic gastritis and gastric carcinoid: experience from a single institution. ( 26928404 )
2016
45
The Evolution of Thyroid Function after Presenting with Hashimoto Thyroiditis Is Different between Initially Euthyroid Girls with and Those without Turner Syndrome. ( 27866202 )
2016
46
Association of Interleukin 10 Gene Polymorphisms with Autoimmune Thyroid Disease: Meta-Analysis. ( 27500787 )
2016
47
Association between functional SIRT1 polymorphisms and the clinical characteristics of patients with autoimmune thyroid disease. ( 27245255 )
2016
48
Diagnostic value of Tg and TgAb for metastasis following ablation in patients with differentiated thyroid carcinoma coexistent with Hashimoto thyroiditis. ( 27158852 )
2016
49
Comprehensive analysis of cytokine gene polymorphisms defines the association of IL-12 gene with ophthalmopthy in Korean children with autoimmune thyroid disease. ( 26850223 )
2016
50
Diplopia, Convergent Strabismus, and Eye Abduction Palsy in a 12-Year-Old Boy with Autoimmune Thyroiditis. ( 27379191 )
2016

Variations for Hashimoto Thyroiditis

Expression for Hashimoto Thyroiditis

Search GEO for disease gene expression data for Hashimoto Thyroiditis.

Pathways for Hashimoto Thyroiditis

Pathways related to Hashimoto Thyroiditis according to KEGG:

36
# Name Kegg Source Accession
1 Autoimmune thyroid disease hsa05320

Pathways related to Hashimoto Thyroiditis according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1 12.73 FAS FASLG IFNG IL4 RET
2
Show member pathways
12.67 FAS FASLG ICAM1 IFNG IL4
3
Show member pathways
12.63 SLC26A4 TG TPO TSHB TSHR
4
Show member pathways
12.35 FAS FASLG ICAM1 IFNG IL4
5
Show member pathways
12.31 CTLA4 FAS IFNG IL4
6
Show member pathways
12.1 CD40 CTLA4 FAS FASLG ICAM1 IFNG
7
Show member pathways
12.05 FAS FASLG IFNG IL4
8 12.01 CTLA4 FAS FASLG IFNG IL4 LGALS3
9 11.78 ICAM1 IFNG IL4 LGALS3
10 11.74 CTLA4 ICAM1 IFNG
11 11.67 ICAM1 IFNG IL4
12
Show member pathways
11.66 CD40 FAS FASLG
13
Show member pathways
11.55 CTLA4 FASLG IFNG IL4
14 11.44 CD40 CTLA4 ICAM1 IL4
15 11.43 FAS FASLG IFNG
16 11.39 CD40 ICAM1 IFNG
17 11.34 CALCA FASLG IFNG
18 11.31 FASLG ICAM1 IFNG
19
Show member pathways
11.19 FAS FASLG IFNG
20 11.13 CD40 IFNG IL4
21 11.1 FAS FASLG ICAM1 IFNG
22 10.71 TSHB TSHR
23 10.11 TG TPO TSHR

GO Terms for Hashimoto Thyroiditis

Cellular components related to Hashimoto Thyroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.63 CD40 FAS FASLG ICAM1 TPO TSHR
2 external side of plasma membrane GO:0009897 9.62 CD40 CTLA4 FASLG ICAM1
3 integral component of plasma membrane GO:0005887 9.61 CD40 CTLA4 FAS FASLG ICAM1 RET
4 membrane raft GO:0045121 9.56 FAS FASLG ICAM1 RET
5 extracellular space GO:0005615 9.32 CALCA CD40 FASLG ICAM1 IFNG IL4
6 extracellular region GO:0005576 10.02 CALCA CD40 FAS FASLG IFNG IL4

Biological processes related to Hashimoto Thyroiditis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 regulation of receptor activity GO:0010469 9.73 CALCA FASLG IFNG IL4 TG TSHB
2 apoptotic signaling pathway GO:0097190 9.65 CD40 FAS FASLG
3 extrinsic apoptotic signaling pathway GO:0097191 9.58 FAS FASLG IFNG
4 response to lipopolysaccharide GO:0032496 9.55 CD40 FAS FASLG ICAM1 PTPN22
5 regulation of regulatory T cell differentiation GO:0045589 9.54 CTLA4 IFNG
6 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.52 FAS FASLG
7 hormone biosynthetic process GO:0042446 9.51 TG TPO
8 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.5 FAS FASLG ICAM1
9 positive regulation of adenylate cyclase activity GO:0045762 9.49 CALCA TSHR
10 positive regulation of isotype switching to IgG isotypes GO:0048304 9.46 CD40 IL4
11 necroptotic signaling pathway GO:0097527 9.43 FAS FASLG
12 iodide transport GO:0015705 9.37 SLC26A4 TG
13 immune response GO:0006955 9.17 AIRE CD40 CTLA4 FAS FASLG IFNG
14 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.13 FAS FASLG LGALS3

Molecular functions related to Hashimoto Thyroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein complex binding GO:0032403 9.26 CALCA ICAM1 KRT19 TSHR
2 receptor activity GO:0004872 9.02 CD40 FAS ICAM1 RET TSHR

Sources for Hashimoto Thyroiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
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47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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