MCID: HSH003
MIFTS: 62

Hashimoto Thyroiditis

Categories: Genetic diseases, Rare diseases, Endocrine diseases, Immune diseases

Aliases & Classifications for Hashimoto Thyroiditis

MalaCards integrated aliases for Hashimoto Thyroiditis:

Name: Hashimoto Thyroiditis 54 12 25 29 13
Autoimmune Thyroiditis 12 50 25 14 69
Chronic Lymphocytic Thyroiditis 12 50 25
Hashimoto's Disease 12 50 25
Lymphocytic Thyroiditis 12 25
Hashimoto's Syndrome 12 50
Hashimoto Disease 25 69
Autoimmune Chronic Lymphocytic Thyroiditis 25
Chronic Lymphocytic Thyroiditides 25
Hashimoto's Thyroiditis 12
Thyroiditis, Autoimmune 42
Hashimotos Thyroiditis 52
Thyroiditis, Chronic 50
Thyroiditis Chronic 52
Hashimoto's Struma 50
Hashimoto Syndrome 25
Hashimoto Struma 25

Characteristics:

OMIM:

54
Inheritance:
autosomal dominant


HPO:

32
hashimoto thyroiditis:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 54 140300
Disease Ontology 12 DOID:7188
ICD10 33 E06.3 E06.2
MeSH 42 D013967
NCIt 47 C38766
SNOMED-CT via HPO 65 263681008 21983002
UMLS 69 C0920350

Summaries for Hashimoto Thyroiditis

NIH Rare Diseases : 50 hashimoto’s syndrome is a form of chronic inflammation that can damage the thyroid, reducing its ability to produce hormones (hypothyroidism). an early sign of the condition may be enlargement of the thyroid (called a goiter), which can potentially interfere with breathing or swallowing. other signs and symptoms may include tiredness, weight gain, thin and dry hair, joint or muscle pain, constipation, cold intolerance, and/or a slowed heart rate. affected women may have irregular menstrual periods or difficulty becoming pregnant. hashimoto’s syndrome is the most common cause of hypothyroidism in the united states. it is more common in women than in men, and it usually appears in mid-adulthood. the exact cause is unknown but it is thought to result from a combination of genetic and environmental factors. treatment is not always needed, but may include taking synthetic thyroid hormone. last updated: 6/30/2015

MalaCards based summary : Hashimoto Thyroiditis, also known as autoimmune thyroiditis, is related to lymphoma and rheumatoid arthritis, and has symptoms including autoimmune antibody positivity An important gene associated with Hashimoto Thyroiditis is CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4), and among its related pathways/superpathways are Influenza A and Immune response Role of DAP12 receptors in NK cells. The drugs Selenium and Glatiramer Acetate have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and myeloid, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Disease Ontology : 12 An autoimmune disease of endocrine system that involves inflammation located in thyroid gland caused by the immune system reacting against its own tissues.

Genetics Home Reference : 25 Hashimoto thyroiditis is a condition that affects the function of the thyroid, which is a butterfly-shaped gland in the lower neck. The thyroid makes hormones that help regulate a wide variety of critical body functions. For example, thyroid hormones influence growth and development, body temperature, heart rate, menstrual cycles, and weight. Hashimoto thyroiditis is a form of chronic inflammation that can damage the thyroid, reducing its ability to produce hormones.

Description from OMIM: 140300

Related Diseases for Hashimoto Thyroiditis

Diseases related to Hashimoto Thyroiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 180)
id Related Disease Score Top Affiliating Genes
1 lymphoma 29.9 AIRE CTLA4 IFNG IL4 TG TPO
2 rheumatoid arthritis 29.8 CTLA4 ICAM1 IFNG IL4 PTPN22
3 systemic lupus erythematosus 29.2 CD40 CTLA4 FASLG ICAM1 IFNG IL4
4 subacute lymphocytic thyroiditis 12.3
5 autoimmune thyroid disease 3 11.1
6 adenohypophysitis 11.0 TG TPO
7 childhood mediastinal neurogenic tumor 11.0 CALCA TG
8 maxillary sinus adenoid cystic carcinoma 11.0 TG TPO
9 autoimmune disease 1 10.9
10 autoimmune thyroid disease 2 10.9
11 myoclonic astatic epilepsy 10.9 IFNG IL4
12 myotubular myopathy with abnormal genital development 10.9 FAS IL4
13 rhabdomyosarcoma, embryonal, 2 10.9 TG TPO
14 hypothyroidism, congenital, nongoitrous 4 10.9 TG TPO TSHB
15 corneal ectasia 10.9 CALCA TG
16 nephrogenic systemic fibrosis 10.9 TG TPO TSHR
17 amelogenesis imperfecta, hypomaturation type, iia6 10.8 TG TPO TSHR
18 cerebral lipidosis 10.8 TG TPO TSHR
19 lung occult large cell carcinoma 10.8 TG TPO TSHR
20 eye accommodation disease 10.8 IFNG IL4
21 cervical endometrial stromal sarcoma 10.8 CALCA TG
22 tick paralysis 10.8 ICAM1 TG TPO
23 chronic polyneuropathy 10.8 RET TG TSHR
24 kidney disease 10.8 RET TG TSHR
25 tibia absent polydactyly arachnoid cyst 10.8 RET TG
26 cartilage disease 10.8 CALCA FAS
27 parachordoma 10.8 RET TG TSHR
28 juvenile sialidosis type 2 10.8 FAS FASLG
29 acute gonococcal prostatitis 10.8 CTLA4 IFNG IL4
30 bolivian hemorrhagic fever 10.8 FASLG ICAM1 IFNG
31 abnormal retinal correspondence 10.7 CTLA4 IFNG IL4
32 childhood testicular mixed germ cell tumor 10.7 FAS FASLG IFNG
33 conjunctival deposit 10.7 CTLA4 TG TPO TSHR
34 acute monoblastic leukemia 10.7 FASLG IFNG IL4
35 benign eccrine breast spiradenoma 10.7 FASLG ICAM1 IFNG
36 background diabetic retinopathy 10.7 TG TPO TSHB TSHR
37 malignant hyperthermia 10.7 CTLA4 IFNG IL4
38 viral encephalitis 10.7 CALCA RET TG
39 primary bacterial infectious disease 10.7 TG TPO TSHB TSHR
40 skin meningioma 10.7 CTLA4 TG TPO TSHR
41 spindle cell hemangioma 10.7 ICAM1 IFNG IL4
42 gastrointestinal tuberculosis 10.7 FAS FASLG
43 acute vascular insufficiency of intestine 10.7 ICAM1 IFNG IL4
44 acute contagious conjunctivitis 10.7 ICAM1 IFNG IL4
45 panhypophysitis 10.7 SLC26A4 TG TSHR
46 ileitis 10.7 ICAM1 IL4
47 corneal intraepithelial neoplasm 10.7 ICAM1 IFNG IL4
48 acute interstitial pneumonia 10.7 ICAM1 IFNG IL4
49 fuchs' heterochromic uveitis 10.7 ICAM1 IFNG IL4
50 medullary thyroid carcinoma, familial 10.7 CALCA RET TG

Graphical network of the top 20 diseases related to Hashimoto Thyroiditis:



Diseases related to Hashimoto Thyroiditis

Symptoms & Phenotypes for Hashimoto Thyroiditis

Symptoms via clinical synopsis from OMIM:

54

Lab:
thyroid autoantibodies
abnormal, small, iodinated protein in the serum
defect in thyroid basement membrane
hashimoto struma

Endocrine:
hashimoto thyroiditis

Immunology:
thyroid autoimmunity


Clinical features from OMIM:

140300

Human phenotypes related to Hashimoto Thyroiditis:

32
id Description HPO Frequency HPO Source Accession
1 hashimoto thyroiditis 32 HP:0000872
2 autoimmune antibody positivity 32 HP:0030057

MGI Mouse Phenotypes related to Hashimoto Thyroiditis:

44 (show all 17)
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.43 AIRE CD40 CTLA4 FAS FASLG ICAM1
2 homeostasis/metabolism MP:0005376 10.4 LGALS3 PTPN22 RET SLC26A4 TG TPO
3 hematopoietic system MP:0005397 10.38 AIRE CD40 CTLA4 FAS FASLG ICAM1
4 immune system MP:0005387 10.36 IL4 LGALS3 PTPN22 RET SLC26A4 TPO
5 digestive/alimentary MP:0005381 10.35 ICAM1 IFNG IL4 KRT19 LGALS3 PTPN22
6 growth/size/body region MP:0005378 10.33 AIRE FAS ICAM1 IFNG IL4 KRT19
7 mortality/aging MP:0010768 10.27 PTPN22 RET TPO TSHR AIRE CTLA4
8 nervous system MP:0003631 10.22 TG TSHR AIRE CD40 FAS FASLG
9 integument MP:0010771 10.1 IFNG IL4 KRT19 LGALS3 CTLA4 FAS
10 neoplasm MP:0002006 10.09 AIRE FAS FASLG ICAM1 IFNG KRT19
11 liver/biliary system MP:0005370 10.08 AIRE CTLA4 FAS FASLG IFNG IL4
12 normal MP:0002873 10.02 AIRE CD40 CTLA4 FAS FASLG IFNG
13 reproductive system MP:0005389 10 AIRE FAS FASLG IFNG IL4 KRT19
14 renal/urinary system MP:0005367 9.97 CD40 FAS FASLG IFNG IL4 LGALS3
15 respiratory system MP:0005388 9.81 LGALS3 PTPN22 RET AIRE CTLA4 FAS
16 skeleton MP:0005390 9.7 CD40 CTLA4 FAS FASLG IFNG IL4
17 vision/eye MP:0005391 9.23 AIRE FAS FASLG ICAM1 IFNG IL4

Drugs & Therapeutics for Hashimoto Thyroiditis

Drugs for Hashimoto Thyroiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 161)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Selenium Approved, Vet_approved Phase 4,Phase 2 7782-49-2
2
Glatiramer Acetate Approved, Investigational Phase 4 147245-92-9 3081884
3
Labetalol Approved Phase 4 36894-69-6 3869
4
Nifedipine Approved Phase 4 21829-25-4 4485
5 Antioxidants Phase 4,Phase 2
6 Micronutrients Phase 4,Phase 2
7 Protective Agents Phase 4,Phase 2,Phase 1
8 Trace Elements Phase 4,Phase 2
9 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1
10 Adjuvants, Immunologic Phase 4
11 Immunosuppressive Agents Phase 4,Phase 3
12 Antihypertensive Agents Phase 4
13 Calcium, Dietary Phase 4,Phase 2
14 Neurotransmitter Agents Phase 4,Phase 3,Phase 1,Phase 2
15 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
16 Epoetin alfa Phase 4 113427-24-0
17 Hematinics Phase 4
18 Adrenergic Agents Phase 4,Phase 1,Phase 2
19 Adrenergic alpha-1 Receptor Antagonists Phase 4
20 Adrenergic alpha-Antagonists Phase 4,Phase 1,Phase 2
21 Adrenergic Antagonists Phase 4,Phase 1,Phase 2
22 Adrenergic beta-Antagonists Phase 4
23 Autonomic Agents Phase 4,Phase 1
24 calcium channel blockers Phase 4
25 Tocolytic Agents Phase 4
26 Vasodilator Agents Phase 4,Phase 1,Phase 2
27 methionine Nutraceutical Phase 4
28
Aripiprazole Approved, Investigational Phase 3,Phase 1 129722-12-9 60795
29 Brexpiprazole Approved Phase 3 913611-97-9 11978813
30
Dopamine Approved Phase 3 51-61-6, 62-31-7 681
31
Palivizumab Approved, Investigational Phase 3 188039-54-5
32
Adalimumab Approved Phase 3,Phase 2 331731-18-1 16219006
33
Ethanol Approved Phase 3 64-17-5 702
34
Naltrexone Approved, Investigational, Vet_approved Phase 3,Phase 1 16590-41-3 5360515
35
Azithromycin Approved Phase 3 83905-01-5 55185 53477736 447043
36
Etanercept Approved, Investigational Phase 3 185243-69-0
37
Methotrexate Approved Phase 3 1959-05-2, 59-05-2 126941
38 Anti-Infective Agents Phase 3,Phase 2,Phase 1
39 Antibodies Phase 3,Phase 2,Phase 1
40 Anti-Inflammatory Agents Phase 3,Phase 2,Phase 1
41 Immunoglobulins Phase 3,Phase 2,Phase 1
42 Antipsychotic Agents Phase 3,Phase 1
43 Central Nervous System Depressants Phase 3,Phase 1
44 Dopamine Agents Phase 3
45 Dopamine agonists Phase 3
46 Psychotropic Drugs Phase 3,Phase 1
47
Serotonin Phase 3 50-67-9 5202
48 Serotonin Agents Phase 3
49 Tranquilizing Agents Phase 3,Phase 1
50 Antiviral Agents Phase 3,Phase 1,Phase 2

Interventional clinical trials:

(show top 50) (show all 81)

id Name Status NCT ID Phase Drugs
1 Selenium Supplementation in Pregnancy Unknown status NCT01465867 Phase 4
2 Glatiramer Acetate for Multiple Sclerosis With Autoimmune Comorbidities Completed NCT01456416 Phase 4
3 Selenium Supplementation in Youths With Autoimmune Thyroiditis Recruiting NCT02644707 Phase 4
4 Effect of Erythropoietin in Refractory Autoimmune Encephalitis Patients Recruiting NCT03004209 Phase 4 Erythropoietin
5 Chronic Hypertension and Pregnancy (CHAP) Project Recruiting NCT02299414 Phase 4 Anti-hypertensive therapy
6 Brexpiprazole (OPC-34712) Trial in the Treatment of Adults With Acute Schizophrenia Completed NCT02054702 Phase 3 Brexpiprazole;Aripiprazole
7 Monotherapy Brexpiprazole (OPC-34712) Trial in the Treatment of Adults With Early-Episode Schizophrenia Completed NCT02013622 Phase 3 Brexpiprazole
8 Brexpiprazole (OPC-34712) as an Adjunctive Treatment in Active Adults, 18 to 35 Years Old, With Major Depressive Disorder Who Are in a School or Work Environment Completed NCT02013609 Phase 3 Brexpiprazole
9 Brexpiprazole (OPC-34712) as an Adjunctive Treatment in Adults With Major Depressive Disorder and Anxiety Symptoms Completed NCT02013531 Phase 3 Brexpiprazole
10 Brexpiprazole as Adjunctive Therapy With Major Depressive Disorder and an Inadequate Response to Previous Adjunctive Therapy Completed NCT02012218 Phase 3 ADT;Brexpiprazole
11 Clinical Study of Palivizumab in Japanese Newborns, Infants and Young Children at the Age of 24 Months or Less With Immunocompromised Medical Conditions Completed NCT01466062 Phase 3 Palivizumab
12 Safety, Efficacy, and Pharmacokinetics of Adalimumab in Japanese Children With Juvenile Rheumatoid Arthritis Completed NCT00690573 Phase 3
13 Self-injection of Adalimumab in Adult Japanese Subjects With Rheumatoid Arthritis Completed NCT00603993 Phase 3
14 A Multicenter, Randomized, Double-blind, Placebo-controlled, 3-parallel-group Comparison Trial to Investigate the Effect of Nalmefene on Alcohol Consumption Reduction in Patients With Alcohol Dependence (Phase 3 Trial) Completed NCT02364947 Phase 3 Nalmefene hydrochloride;Placebo
15 A Study of Adalimumab in Adult Japanese Subjects With Rheumatoid Arthritis Completed NCT00647491 Phase 2, Phase 3
16 Adalimumab in Adult Japanese Subjects With Rheumatoid Arthritis Completed NCT00235872 Phase 3
17 A Trial Of Azithromycin SR For The Treatment Of Laryngopharyngitis or Tonsillitis or Acute Bacterial Rhinosinusitis Completed NCT00393835 Phase 3 Azithromycin SR
18 Comparison of CHS-0214 to Enbrel (Etanercept) in Patients With Rheumatoid Arthritis (RA) Completed NCT02115750 Phase 3 Etanercept;CHS-0214
19 Assess Safety and Efficacy of Vilaprisan in Subjects With Uterine Fibroids Recruiting NCT03194646 Phase 3 Vilaprisan (BAY1002670);Vilaprisan (BAY1002670);Vilaprisan (BAY1002670);Vilaprisan (BAY1002670);Vilaprisan (BAY1002670);Vilaprisan (BAY1002670)
20 Brexpiprazole (OPC 34712) Trial in the Treatment of Adults With Major Depressive Disorder and Irritability Withdrawn NCT02212613 Phase 3 Brexpiprazole
21 Effect of Semet (80 and 160 mcg) Versus Placebo in Euthyroid Patients With AIT Unknown status NCT02302768 Phase 2
22 Low-Level Laser Therapy in Chronic Autoimmune Thyroiditis Completed NCT01129492 Phase 2
23 Evaluating the Dietary Supplement Anatabloc in Thyroid Health-ASAP (Antabloc Supplementation Autoimmune Prevention) Completed NCT01551498 Phase 2
24 An Open Study of Sulforaphane-rich Broccoli Sprout Extract in Patients With Schizophrenia Completed NCT01716858 Phase 2
25 A Phase 2 Trial of Rebamipide Liquid to Determine the Effective Dose for Prevention of Chemoradiotherapy-induced Oral Mucositis in Patients With Head and Neck Cancer Completed NCT02085460 Phase 2 Placebo;2% Rebamipide liquid;4% Rebamipide liquid
26 Adalimumab in Adult Japanese Subjects With Rheumatoid Arthritis Completed NCT00235833 Phase 2
27 The Role of Immunomodulatory Treatment in Success of ICSI in Patients With Autoimmune Thyroiditis Recruiting NCT03289403 Phase 2 Immunomodulatory;Thyroxine
28 Ifenprodil Tartrate Treatment of Adolescents With Post-traumatic Stress Disorder: a Double-blind, Placebo-controlled Trial Recruiting NCT01896388 Phase 1, Phase 2 Ifenprodil Tartrate;Placebo
29 Tipepidine in Children With Attention Deficit/Hyperactivity Disorder (AD/HD): a Double-blind, Placebo-controlled Trial Recruiting NCT02305134 Phase 1, Phase 2 Tipepidine Hibenzate;Placebo
30 A Phase 2 Trial to Evaluate the Efficacy and Safety of OCV-501 in Elderly Patients With Acute Myeloid Leukemia Active, not recruiting NCT01961882 Phase 2 OCV-501;Placebo
31 IL-2 in Refractory Autoimmune Encephalitis Not yet recruiting NCT02714959 Phase 1, Phase 2 Proleukin
32 Eradication of H. Pylori Therapy Individualized by the Mutation of 23S rRNA of H. Pylori Not yet recruiting NCT02761005 Phase 2 Eradication of H. pylori
33 Infections and Autoimmunity: Autobodies Screening in Multiple Sclerosis Unknown status NCT00230204 Phase 1
34 A Study of Sustained-Release Liothyronine Sodium (T3) in Healthy Subjects Completed NCT01581463 Phase 1 Liothyronine, Sodium
35 A Phase 1 Study of OCV-C02 in Patients With Advanced or Relapsed Colorectal Cancer Completed NCT01801930 Phase 1 OCV-103 and OCV-104;OCV-103 and OCV-104;OCV-103 and OCV-104;OCV-103 and OCV-104
36 A Single-center, Open-label, Single-dose Study Investigating the Safety, Tolerability, and Pharmacokinetic Properties of Nalmefene 10 mg Tablets in Healthy Japanese Male Subjects Completed NCT02679469 Phase 1 nalmefene hydrochloride 10 mg
37 A Multicenter Open-label Study Investigating the Pharmacokinetics and Safety of Aripiprazole IM Depot Formulation (OPC-14597 IMD) During Repeated Administration by Injection Into the Deltoid Muscle in Patients With Schizophrenia Completed NCT02220712 Phase 1 OPC-14597 IMD
38 Pharmacodynamic Study of Cilostazol in Healthy Volunteers Recruiting NCT02554721 Phase 1 Cilostazol;Acetylsalicylic acid;Clopidogrel
39 First-in-Human Dose Escalation Study of M201-A in Healthy Japanese Subjects Recruiting NCT03055403 Phase 1 M201-A Injection;Placebo
40 Phase 1 Study of SGI-110 in Patients With Acute Myeloid Leukemia Active, not recruiting NCT02293993 Phase 1 SGI-110
41 The Effect of Plaquenil on Serum Inflammatory Markers and Goiter in Euthyroid Young Women With Hashimoto's Thyroiditis Unknown status NCT02126683 Hydroxychloroquine
42 Hashimoto - a Surgical Disease. Absolute Total Thyroidectomy Makes Antibodies Disappear and Ameliorates Symptoms Unknown status NCT02319538 medical hormone treatment (Thyroxine)
43 CXCL9 and CXCL11 Levels in Patients With Autoimmune Thyroiditis and Habitual Abortions Unknown status NCT01644318
44 The Influence of Psychobiological Adversity to Children and Adolescents With Type 1 Diabetes Unknown status NCT02575001
45 Fetuin A in Hashimoto Thyroiditis Completed NCT01884649
46 Hashimotos Thyroiditis and Thyroid Cancer Completed NCT01428167
47 The Effect of Hydroxychloroquine Treatment in Hashimoto's Thyroiditis Completed NCT01760421 Hydroxychloroquine
48 Isolated ACTH Deficiency in Patients With Hashimoto Thyroiditis Completed NCT00552487 synacthen
49 Evaluation of Oxidative Stress and Effect of Levothyroxine Treatment on Oxidative Stress in Hashimoto Disease Completed NCT01102205
50 Oxidative Status in Children With Autoimmune Thyroiditis Completed NCT02318160

Search NIH Clinical Center for Hashimoto Thyroiditis

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: thyroiditis, autoimmune

Genetic Tests for Hashimoto Thyroiditis

Genetic tests related to Hashimoto Thyroiditis:

id Genetic test Affiliating Genes
1 Hashimoto Thyroiditis 29

Anatomical Context for Hashimoto Thyroiditis

MalaCards organs/tissues related to Hashimoto Thyroiditis:

39
Thyroid, Heart, Myeloid, B Cells, Bone, Testes, Tonsil

Publications for Hashimoto Thyroiditis

Articles related to Hashimoto Thyroiditis:

(show top 50) (show all 131)
id Title Authors Year
1
Protein oxidation and autoantibodies' reactivity against malondialdehyde and hydrogen peroxide-modified thyroid antigens in plasma of patients with Graves' disease and Hashimoto Thyroiditis. ( 28431875 )
2017
2
BRAF(V600E) mutation contributes papillary thyroid carcinoma and Hashimoto thyroiditis with resistance to thyroid hormone: A case report and literature review. ( 28928829 )
2017
3
HASHIMOTO THYROIDITIS AND VESTIBULAR DYSFUNCTION. ( 28534686 )
2017
4
A concise review of Hashimoto thyroiditis (HT) and the importance of iodine, selenium, vitamin D and gluten on the autoimmunity and dietary management of HT patients.Points that need more investigation. ( 28315909 )
2017
5
Association of vitamin D insufficiency/deficiency with thyroid artery Doppler ultrasonography in patients with Hashimoto thyroiditis. ( 28523025 )
2017
6
Effects of Vitamin D deficiency treatment on metabolic markers in Hashimoto thyroiditis patients. ( 28400827 )
2017
7
Monogenic Hashimoto thyroiditis associated with a variant in the thyroglobulin (TG) gene. ( 28942902 )
2017
8
Immunological Mechanisms Implicated in the Pathogenesis of Chronic Urticaria and Hashimoto Thyroiditis. ( 28865416 )
2017
9
Myxedema Psychosis in a Patient With Undiagnosed Hashimoto Thyroiditis. ( 28055088 )
2017
10
Concurrent Linear Immunoglobulin A Dermatosis, Hashimoto Thyroiditis, and Immunoglobulin A Nephropathy in an Adult. ( 28392654 )
2017
11
Hashimoto thyroiditis, anti-thyroid antibodies and systemic lupus erythematosus. ( 28544477 )
2017
12
Elevated interleukin-1I^ in peripheral blood mononuclear cells contributes to the pathogenesis of autoimmune thyroid diseases, especially of Hashimoto thyroiditis. ( 26864865 )
2016
13
RANKL/Osteoprotegerin System and Bone Turnover in Hashimoto Thyroiditis. ( 27328677 )
2016
14
Erratum: Diagnostic difficulties by the unusual presentations in children and adolescents with Hashimoto thyroiditis. ( 28164080 )
2016
15
Mulberry cells in the thyroid: warthin-finkeldey-like cells in hashimoto thyroiditis-associated lymphoma. ( 28024116 )
2016
16
Celiac disease in children and adolescents with Hashimoto Thyroiditis. ( 27489467 )
2016
17
Hashimoto Thyroiditis and Nephrocalcinosis in a Child with Down Syndrome. ( 27147809 )
2016
18
The Evolution of Thyroid Function after Presenting with Hashimoto Thyroiditis Is Different between Initially Euthyroid Girls with and Those without Turner Syndrome. ( 27866202 )
2016
19
Risk of Depression, Chronic Morbidities, and l-Thyroxine Treatment in Hashimoto Thyroiditis in Taiwan: A Nationwide Cohort Study. ( 26871858 )
2016
20
Gene Map of the HLA Region, Graves' Disease and Hashimoto Thyroiditis, and Hematopoietic Stem Cell Transplantation. ( 26791860 )
2016
21
Co-Existence of Thyroid Nodule and Thyroid Cancer in Children and Adolescents with Hashimoto Thyroiditis: A Single-Center Study. ( 26910846 )
2016
22
Diagnostic value of Tg and TgAb for metastasis following ablation in patients with differentiated thyroid carcinoma coexistent with Hashimoto thyroiditis. ( 27158852 )
2016
23
Letter to the Editor: Comment on "Thyroid stimulating antibodies are highly prevalent in Hashimoto thyroiditis and associated orbitopathy" Dear Editor. ( 27255721 )
2016
24
Potential Influence of Selenium, Copper, Zinc and Cadmium on L-Thyroxine Substitution in Patients with Hashimoto Thyroiditis and Hypothyroidism. ( 27793066 )
2016
25
Sonographic Features of Nodular Hashimoto Thyroiditis. ( 27556192 )
2016
26
Diagnostic difficulties by the unusual presentations in children and adolescents with Hashimoto thyroiditis. ( 27777910 )
2016
27
Hashimoto thyroiditis with an unusual presentation of cardiac tamponade in Noonan syndrome. ( 28018461 )
2016
28
Using Hashimoto thyroiditis as gold standard to determine the upper limit value of thyroid stimulating hormone in a Chinese cohort. ( 27816062 )
2016
29
Assessment of ovarian reserve in euthyroid adolescents with Hashimoto thyroiditis. ( 26608409 )
2016
30
HURTLE CELLS IMMUNOHISTOCHEMICAL ACTIVITIES IN HASHIMOTO THYROIDITIS PARENCHYMA. ( 28009314 )
2016
31
Helicobacter pylori infection in women with Hashimoto thyroiditis: A case-control study. ( 27442635 )
2016
32
An Adolescent Boy with Comorbid Anorexia Nervosa and Hashimoto Thyroiditis. ( 26757948 )
2016
33
HASHIMOTO THYROIDITIS NOT ASSOCIATED WITH VITAMIN D DEFICIENCY. ( 27018618 )
2016
34
Excess iodine promotes apoptosis of thyroid follicular epithelial cells by inducing autophagy suppression and is associated with Hashimoto thyroiditis disease. ( 27448770 )
2016
35
The Effects of Hashimoto Thyroiditis on Lymph Node Metastases in Unifocal and Multifocal Papillary Thyroid Carcinoma: A Retrospective Chinese Cohort Study. ( 26871795 )
2016
36
Cytokine production in patients with papillary thyroid cancer and associated autoimmune Hashimoto thyroiditis. ( 25971541 )
2015
37
Quality of life improvement in patients with Hashimoto thyroiditis and other goiters after surgery: A prospective cohort study. ( 26254997 )
2015
38
Using Acoustic Structure Quantification During B-Mode Sonography for Evaluation of Hashimoto Thyroiditis. ( 26543169 )
2015
39
Efficacy of a food supplement in patients with hashimoto thyroiditis. ( 25864745 )
2015
40
Levothyroxine Treatment of Euthyroid Children with Autoimmune Hashimoto Thyroiditis: Results of a Multicenter, Randomized, Controlled Trial. ( 26279111 )
2015
41
PRDM1 expression via human parvovirus B19 infection plays a role in the pathogenesis of Hashimoto thyroiditis. ( 26475096 )
2015
42
The possible role of CD4(+)CD25 (high)Foxp3 (+)/CD4 (+)IL-17A (+) cell imbalance in the autoimmunity of patients with Hashimoto thyroiditis. ( 25771887 )
2015
43
Is diffusion-weighted imaging useful for differentiation between Graves' disease and Hashimoto thyroiditis? ( 26744855 )
2015
44
The Clinical Relevance of Psammoma Body and Hashimoto Thyroiditis in Papillary Thyroid Carcinoma: A Large Case-control Study. ( 26554782 )
2015
45
The role of diffusion weighted MR imaging for differentiation between Graves' disease and Hashimoto thyroiditis. ( 26241532 )
2015
46
The effect of Hashimoto thyroiditis to low-dose (1,100 MBq) radioactive-iodine remnant ablation. ( 25899980 )
2015
47
Overlapping Morphologic and Immunohistochemical Features of Hashimoto Thyroiditis and IgG4-Related Thyroid Disease. ( 25898816 )
2015
48
Deficiency of respiratory chain complex I in Hashimoto thyroiditis. ( 26554844 )
2015
49
Hashimoto thyroiditis onset after laparoscopic removal of struma ovarii: an overview to unravel a rare and intriguing finding. ( 26524822 )
2015
50
Diagnostic value of strain ratio measurement in differential diagnosis of thyroid nodules coexisted with Hashimoto thyroiditis. ( 26131268 )
2015

Variations for Hashimoto Thyroiditis

Expression for Hashimoto Thyroiditis

Search GEO for disease gene expression data for Hashimoto Thyroiditis.

Pathways for Hashimoto Thyroiditis

Pathways related to Hashimoto Thyroiditis according to GeneCards Suite gene sharing:

(show all 22)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.67 FAS FASLG ICAM1 IFNG IL4
2
Show member pathways
12.37 FAS FASLG ICAM1 IFNG IL4
3
Show member pathways
12.32 CTLA4 FAS IFNG IL4
4
Show member pathways
12.2 SLC26A4 TG TPO TSHB TSHR
5
Show member pathways
12.1 CD40 CTLA4 FAS FASLG ICAM1 IFNG
6
Show member pathways
12.07 FAS FASLG IFNG IL4
7 12 CTLA4 FAS FASLG IFNG IL4 LGALS3
8 11.81 ICAM1 IFNG IL4 LGALS3
9 11.73 CTLA4 ICAM1 IFNG
10 11.67 ICAM1 IFNG IL4
11
Show member pathways
11.67 CD40 FAS FASLG
12
Show member pathways
11.55 CTLA4 FASLG IFNG IL4
13 11.47 CD40 CTLA4 ICAM1 IL4
14 11.44 FAS FASLG IFNG
15 11.4 CD40 ICAM1 IFNG
16 11.35 CALCA FASLG IFNG
17 11.33 FASLG ICAM1 IFNG
18
Show member pathways
11.26 FAS FASLG IFNG
19 11.15 CD40 IFNG IL4
20 11.1 FAS FASLG ICAM1 IFNG
21 10.71 TSHB TSHR
22 10.11 TG TPO TSHR

GO Terms for Hashimoto Thyroiditis

Cellular components related to Hashimoto Thyroiditis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.81 CD40 CTLA4 FAS FASLG ICAM1 RET
2 cell surface GO:0009986 9.73 CD40 FAS FASLG ICAM1 TPO TSHR
3 membrane raft GO:0045121 9.62 FAS FASLG ICAM1 RET
4 extracellular space GO:0005615 9.61 CALCA CD40 FASLG ICAM1 IFNG IL4
5 external side of plasma membrane GO:0009897 9.17 CD40 CTLA4 FAS FASLG ICAM1 IFNG
6 extracellular region GO:0005576 10.02 CALCA CD40 FAS FASLG IFNG IL4

Biological processes related to Hashimoto Thyroiditis according to GeneCards Suite gene sharing:

(show all 24)
id Name GO ID Score Top Affiliating Genes
1 regulation of immune response GO:0050776 9.84 CD40 ICAM1 IFNG IL4
2 positive regulation of protein phosphorylation GO:0001934 9.8 CD40 FAS IFNG IL4
3 apoptotic signaling pathway GO:0097190 9.73 CD40 FAS FASLG
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.72 CD40 IFNG IL4
5 response to lipopolysaccharide GO:0032496 9.72 CD40 FAS FASLG ICAM1 PTPN22
6 immune response GO:0006955 9.7 AIRE CD40 CTLA4 FAS FASLG IFNG
7 extrinsic apoptotic signaling pathway GO:0097191 9.65 FAS FASLG IFNG
8 positive regulation of endothelial cell apoptotic process GO:2000353 9.62 CD40 FASLG
9 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.61 FAS FASLG
10 hormone biosynthetic process GO:0042446 9.61 TG TPO
11 negative thymic T cell selection GO:0045060 9.59 AIRE FAS
12 positive regulation of adenylate cyclase activity GO:0045762 9.58 CALCA TSHR
13 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 9.58 FAS RET
14 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.58 FAS FASLG ICAM1
15 positive regulation of chemokine biosynthetic process GO:0045080 9.57 IFNG IL4
16 defense response to protozoan GO:0042832 9.54 CD40 IFNG IL4
17 positive regulation of MHC class II biosynthetic process GO:0045348 9.52 IFNG IL4
18 necroptotic signaling pathway GO:0097527 9.51 FAS FASLG
19 iodide transport GO:0015705 9.46 SLC26A4 TG
20 positive regulation of mononuclear cell migration GO:0071677 9.43 IL4 LGALS3
21 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.43 FAS FASLG LGALS3
22 regulation of myeloid cell differentiation GO:0045637 9.3 FAS
23 positive regulation of isotype switching to IgG isotypes GO:0048304 9.13 CD40 IFNG IL4
24 inflammatory cell apoptotic process GO:0006925 8.8 FAS FASLG IFNG

Molecular functions related to Hashimoto Thyroiditis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein complex binding GO:0032403 9.26 CALCA ICAM1 KRT19 TSHR
2 receptor activity GO:0004872 9.02 CD40 FAS ICAM1 RET TSHR

Sources for Hashimoto Thyroiditis

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