HCL-V
MCID: HCL001
MIFTS: 16

Hcl-V (HCL-V) malady

Blood, Cancer categories

Summaries for Hcl-V

Sources:
33MalaCards
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MalaCards: Hcl-V, also known as hairy cell leukemia variant, is related to polycythemia vera and lymphoma, somatic. An important gene associated with Hcl-V is IGHV4-34 (immunoglobulin heavy variable 4-34).

Aliases & Classifications for Hcl-V

Sources:
8Disease Ontology, 49Orphanet, 61UMLS, 40NCIt, 57SNOMED-CT, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood


Characteristics (Orphanet epidemiological data):

49
hairy cell leukemia variant:
Inheritance: Multigenic/multifactorial; Age of onset: Adulthood; Age of death: Adult


Aliases & Descriptions:

hcl-v 8 49
hairy cell leukemia variant 8 49 61
prolymphocytic variant of hairy cell leukemia 49
leukemic reticuloendotheliosis variant 49
prolymphocytic variant of hcl 49
hairy cell leukaemia variant 8


External Ids:

Disease Ontology8 DOID:713
NCIt40 C7401
SNOMED-CT57 54087003, 277568007
ICD10 via Orphanet26 C91.4

Related Diseases for Hcl-V

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hcl-V via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1polycythemia vera10.5
2lymphoma, somatic10.3
3refractory hairy cell leukemia10.2

Clinical Features for Hcl-V

Drugs & Therapeutics for Hcl-V

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Hcl-V

Drug clinical trials:

Search ClinicalTrials for Hcl-V

Search NIH Clinical Center for Hcl-V

Search CenterWatch for Hcl-V

Genetic Tests for Hcl-V

Anatomical Context for Hcl-V

Animal Models for Hcl-V or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Hcl-V

Sources:
51PubMed
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Articles related to Hcl-V:

idTitleAuthorsYear
1
Establishment of a hairy cell leukemia variant cell line, HCLv-07. (19332987)
2009
2
Human RNA 5'-kinase (hClp1) can function as a tRNA splicing enzyme in vivo. (18648070)
2008
3
Up-Regulation of Interleukin-9 and the Interleukin-9-Associated Calcium-Activated Chloride Channel hCLCA1 in Nasal Mucosa Following In Vivo Allergen Challenge. (20525149)
2007
4
hCLE/CGI-99, a human protein that interacts with the influenza virus polymerase, is a mRNA transcription modulator. (16950395)
2006

Genetic Variations for Hcl-V

Expression for genes affiliated with Hcl-V

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hcl-V

Search GEO for disease gene expression data for Hcl-V.

Pathways for genes affiliated with Hcl-V

Compounds for genes affiliated with Hcl-V

GO Terms for genes affiliated with Hcl-V

Products for genes affiliated with Hcl-V

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hcl-V

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet