MCID: HDN002
MIFTS: 48

Head Injury malady

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Summaries for Head Injury

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Sources:
34MedlinePlus, 44NINDS, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Chances are you've bumped your head before. usually, the injury is minor because your skull is hard and it protects your brain. but other head injuries can be more severe, such as a skull fracture, concussion, or traumatic brain injury. head injuries can be open or closed. a closed injury does not break through the skull. with an open, or penetrating, injury, an object pierces the skull and enters brain tissue. closed injuries are not always less severe than open injuries. some common causes of head injuries are falls, motor vehicle accidents, violence, and sports injuries. it is important to know the warning signs of a moderate or severe head injury. get help immediately if the injured person has a headache that gets worse or does not go away repeated vomiting or nausea convulsions or seizures an inability to wake up dilation of one or both pupils of the eyes slurred speech weakness or numbness in the arms or legs loss of coordination increased confusion, restlessness, or agitation nih: national institute of neurological disorders and stroke

MalaCards: Head Injury, also known as head injuries, is related to parkinson's disease and dementia. An important gene associated with Head Injury is NTF4 (neurotrophin 4), and among its related pathways are Nuclear signaling by ERBB4 and Neuroscience. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes, and related mouse phenotypes are homeostasis/metabolism and nervous system.

NINDS:44 Traumatic brain injury (TBI), a form of

Wikipedia:65 Any injury that results in trauma to the scalp, skull, or brain can be classified as a head injury. The... more...

Aliases & Classifications for Head Injury

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Sources:
44NINDS, 34MedlinePlus, 25ICD10
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Related Diseases for Head Injury

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Head Injury:



Diseases related to head injury

Symptoms for Head Injury

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Drugs & Therapeutics for Head Injury

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Head Injury

Search NIH Clinical Center for Head Injury

Genetic Tests for Head Injury

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Anatomical Context for Head Injury

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Sources:
33MalaCards
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MalaCards organs/tissues related to Head Injury:

33
Brain, Eye, Testes, Pituitary, Endothelial, Bone, T cells, Spinal cord, Cortex, Heart

Animal Models for Head Injury or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Head Injury:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7FABP7, CHAT, CHRM1, APOE, GFAP
2MP:00036317.0GFAP, APOE, CHRM1, CHAT, FABP7, NTF4
3MP:00053866.8S100B, GFAP, APOE, CHRM1, CHAT, FABP7

Publications for Head Injury

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Sources:
52PubMed
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Articles related to Head Injury:

(show top 50)    (show all 689)
idTitleAuthorsYear
1
Head injury. (23431655)
2013
2
Batting head injury in professional cricket: a systematic video analysis of helmet safety characteristics. (23418269)
2013
3
Predicting mortality from head injury: experience of Sancti SpA-ritus province, Cuba. (23934424)
2013
4
Late-onset sensorineural hearing loss due to congenital cytomegalovirus infection: could head injury be a trigger? (23025246)
2013
5
An analysis of predictive markers for intracranial haemorrhage in warfarinised head injury patients. (22362648)
2013
6
Epidemiology of paediatric minor head injury: Comparison of injury characteristics with Indices of Multiple Deprivation. (23958554)
2013
7
Urgent intracranial carotid artery decompression after penetrating head injury. (23634269)
2013
8
Early postinjury exercise reverses memory deficits and retards the progression of closed-head injury in mice. (23184513)
2013
9
Computed tomography after decompressive craniectomy for head injury. (23564139)
2013
10
Delayed neurological deterioration after mild head injury: cause, temporal course, and outcomes. (23867298)
2013
11
Susceptibility of the MMPI-2-RF Neurological Complaints and Cognitive Complaints Scales to Over-reporting in Simulated Head Injury. (24191968)
2013
12
Annals of Emergency Medicine Journal Club. Biomarkers revisited: study design, validity, and STARD: Will S100-B affect computed tomography use in head injury patients?: Answers to the March 2012 Journal Club questions. (22818373)
2012
13
Role of hyperbaric oxygen therapy in severe head injury in children. (22837768)
2012
14
Carotid artery dissection presenting with isolated headache and Horner syndrome after minor head injury. (22633727)
2012
15
In vivo bioluminescent imaging of a new model of infectious complications in head-injury rats. (21806472)
2012
16
Head injury or head motion? Assessment and quantification of motion artifacts in diffusion tensor imaging studies. (21391258)
2012
17
Serum levels of protein S100B predict intracranial lesions in mild head injury. (22285378)
2012
18
Predicting the need for CT imaging in children with minor head injury using an ensemble of Naive Bayes classifiers. (22196718)
2012
19
Chest injuries associated with head injury. (24027384)
2012
20
A microdialysis study of oral vigabatrin administration in head injury patients: preliminary evaluation of multimodality monitoring. (22327707)
2012
21
GP is held entirely responsible for brain damage of child who was discharged from hospital after head injury. (23169810)
2012
22
Outcome analysis and outcome predictors of traumatic head injury in childhood: Analysis of 454 observations. (21769206)
2011
23
Clinical decision rules for children with minor head injury: a systematic review. (21310894)
2011
24
Tectorial membrane injury: frequently overlooked in pediatric traumatic head injury. (21852371)
2011
25
Comparative yield of positive brain computed tomography after implementing the NICE or SIGN head injury guidelines in two equivalent urban populations. (21296343)
2011
26
Controversial treatment of a victim of severe head injury complicated by septic shock and acute respiratory distress syndrome. (23754904)
2011
27
Head injury causation scenarios for belted, rear-seated children in frontal impacts. (21259175)
2011
28
Prognostic value of magnetic resonance imaging in moderate and severe head injury: a prospective study of early MRI findings and one-year outcome. (21401308)
2011
29
White-eyed medial wall blowout fracture mimicking head injury due to persistent oculocardiac reflex. (21959489)
2011
30
Permanent post-concussion symptoms after mild head injury. (21401372)
2011
31
The role of anxiety sensitivity in symptom perception after minor head injury: an exploratory study. (22077534)
2011
32
Development of head injury assessment reference values based on NASA injury modeling. (22869304)
2011
33
Coagulopathy in moderate head injury. The role of early administration of low molecular weight heparin. (20642324)
2010
34
Six nails in the head: multiple pneumatic nail gun head injury. (20726759)
2010
35
CATCH: a clinical decision rule for the use of computed tomography in children with minor head injury. (20142371)
2010
36
Automated assessment of midline shift in head injury patients. (20663606)
2010
37
Cerebellar infarction after head injury. (20606808)
2010
38
Severe head injury: control of physiological variables, organ failure and complications in the intensive care unit. (17711565)
2007
39
Oxidative damage after severe head injury and its relationship to neurological outcome. (12234402)
2002
40
Anterior hypopituitarism with unusual delayed onset of diabetes insipidus after penetrating head injury. (12362120)
2002
41
Soluble adhesion molecules in CSF are increased in children with severe head injury. (9814634)
1998
42
Transient global amnesia triggered by mild head injury. (9653523)
1998
43
Motor and cognitive deficits in apolipoprotein E-deficient mice after closed head injury. (9284075)
1997
44
Comparison of serial S-100 and NSE serum measurements after severe head injury. (9479423)
1997
45
HM-PAO-SPECT in persistent vegetative state after head injury: prognostic indicator of the likelihood of recovery? (2071761)
1991
46
Severe head injury: effect upon cellular immune function. (1675441)
1991
47
Accommodative esotropia after ocular and head injury. (2301531)
1990
48
Paroxysmal choreoathetosis after head injury. (3746316)
1986
49
Internal carotid artery thrombosis secondary to closed head injury. (5434376)
1970
50
Intracranial thrombosis of the internal carotid artery after closed head injury. (5360046)
1969

Variations for Head Injury

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Expression for genes affiliated with Head Injury

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Head Injury

Search GEO for disease gene expression data for Head Injury.

Pathways for genes affiliated with Head Injury

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Sources:
50PathCards, 55Reactome, 5Cell Signaling Technology
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Pathways related to Head Injury according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5S100B, GFAP
28.3S100B, FABP7, APOE, GFAP

Compounds for genes affiliated with Head Injury

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Sources:
45Novoseek, 29IUPHAR, 24HMDB, 11DrugBank, 51PharmGKB, 61Tocris Bioscience
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Compounds related to Head Injury according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1eosin459.9GFAP, S100B
2s 100459.9S100B, GFAP
32,3-cyclic nucleotide459.8GFAP, S100B
4reticulin459.8S100B, GFAP
5propentofylline459.7GFAP, CHAT
6edss459.6S100B, APOE
7scopolamine45 29 24 1112.6CHRM1, CHAT
8pirenzepine45 29 1111.5CHRM1, CHAT
9homovanillic acid45 2410.4GFAP, CHAT
10quinolinic acid45 2410.4NTF4, CHAT, GFAP
11bromodeoxyuridine459.3NUDT6, GFAP, S100B
12benzodiazepine459.3CHAT, GFAP
13formaldehyde45 2410.2S100B, CHAT, GFAP
145-hydroxytryptamine459.2CHAT, CHRM1, GFAP
15l-amino acid459.1S100B, CHAT
16adenylate459.1S100B, NTF4, CHRM1, GFAP
17streptozotocin459.0APOE, GFAP, NUDT6
18donepezil45 51 24 1112.0CHAT, CHRM1, APOE
19olanzapine45 51 29 24 1113.0CHAT, CHRM1, APOE
20methionine458.9NUDT6, GFAP, S100B
21cocaine45 119.9GFAP, CHRM1, CHAT, S100B
22potassium45 24 1110.8GFAP, CHRM1, CHAT, S100B
23nicotine45 29 51 1111.8CHAT, CHRM1, APOE
24dbc-amp458.8NUDT6, GFAP, CHAT, S100B
25cyclic amp45 249.8GFAP, CHRM1, CHAT, S100B
26lactate458.8S100B, CHAT, GFAP, NUDT6
27phosphatidylinositol458.7NTF4, CHAT, CHRM1, NUDT6
28ethanol45 51 24 1111.6GFAP, CHRM1, CHAT, NTF4, S100B
29gaba458.5GFAP, CHRM1, CHAT, FABP7, S100B
30nitric oxide45 24 1110.5NUDT6, CHRM1, CHAT, S100B
31paraffin458.5GFAP, APOE, CHAT, S100B
32forskolin45 51 1110.5NUDT6, GFAP, CHAT, NTF4, S100B
33aspartate458.4S100B, CHAT, APOE, GFAP
34vegf458.4S100B, APOE, GFAP, NUDT6
35kainate45 299.4NUDT6, GFAP, APOE, CHAT
36atp45 299.3NUDT6, GFAP, CHRM1, CHAT, S100B
37serine458.1NUDT6, GFAP, APOE, NTF4, S100B
38estrogen458.1S100B, CHAT, APOE, GFAP
39retinoic acid45 249.1NUDT6, GFAP, CHAT, FABP7, NTF4, S100B
40nmda45 299.1NTF4, CHAT, APOE, GFAP, NUDT6
41choline45 24 1110.0NUDT6, GFAP, CHRM1, CHAT, NTF4, S100B
42tyrosine458.0NUDT6, GFAP, CHRM1, CHAT, NTF4, S100B
43testosterone45 61 24 1111.0NUDT6, GFAP, APOE, CHAT, S100B
44calcium45 51 24 1111.0NUDT6, GFAP, CHRM1, CHAT, NTF4, S100B
45arginine457.8NUDT6, GFAP, APOE, CHRM1, NTF4, S100B
46alanine457.7GFAP, APOE, CHRM1, CHAT, NTF4, S100B
47lipid457.7GFAP, APOE, CHRM1, CHAT, FABP7, S100B
48dopamine45 29 24 1110.6NUDT6, GFAP, APOE, CHRM1, CHAT, S100B
49acetylcholine45 51 29 24 1111.2S100B, NUDT6, GFAP, APOE, CHRM1, CHAT
50glutamate456.9NUDT6, GFAP, APOE, CHRM1, CHAT, FABP7

GO Terms for genes affiliated with Head Injury

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Sources:
16Gene Ontology
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Cellular components related to Head Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430258.2S100B, FABP7, CHAT, APOE

Biological processes related to Head Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1long-term synaptic potentiationGO:0602919.5S100B, GFAP
2regulation of neuronal synaptic plasticityGO:0481689.1S100B, APOE
3neuromuscular synaptic transmissionGO:0072749.1CHAT, CHRM1

Molecular functions related to Head Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tau protein bindingGO:0481569.2S100B, APOE

Products for genes affiliated with Head Injury

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Sources for Head Injury

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet