MCID: HDN002
MIFTS: 36

Head Injury malady

Summaries for Head Injury

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Sources:
33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Chances are you've bumped your head before. usually, the injury is minor because your skull is hard and it protects your brain. but other head injuries can be more severe, such as a skull fracture, concussion, or traumatic brain injury. head injuries can be open or closed. a closed injury does not break through the skull. with an open, or penetrating, injury, an object pierces the skull and enters brain tissue. closed injuries are not always less severe than open injuries. some common causes of head injuries are falls, motor vehicle accidents, violence, and sports injuries. it is important to know the warning signs of a moderate or severe head injury. get help immediately if the injured person has a headache that gets worse or does not go away repeated vomiting or nausea convulsions or seizures an inability to wake up dilation of one or both pupils of the eyes slurred speech weakness or numbness in the arms or legs loss of coordination increased confusion, restlessness, or agitation nih: national institute of neurological disorders and stroke

MalaCards: Head Injury, also known as head injuries, is related to hypertension and parkinson's disease. An important gene associated with Head Injury is NTF4 (neurotrophin 4), and among its related pathways is Neuroscience. The compounds estrogen and edss have been mentioned in the context of this disorder. Affiliated tissues include brain and eye, and related mouse phenotypes are behavior/neurological and nervous system.

NINDS:43 Traumatic brain injury (TBI), a form of

Wikipedia:63 Any injury that results in trauma to the scalp, skull, or brain can be classified as a head injury. The... more...

Aliases & Classifications for Head Injury

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Sources:
43NINDS, 33MedlinePlus, 25ICD10
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Related Diseases for Head Injury

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Head Injury via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 200)
idRelated DiseaseScoreTop Affiliating Genes
1hypertension30.3DBH, APOE
2parkinson's disease30.3NUDT6, DBH, NTF4, CHAT, APOE
3dementia30.3APOE, SYP, CHAT, CHRM1, CX3CL1, TTF2
4migraine30.1DBH
5medulloblastoma30.1S100B, SYP, NUDT6, GFAP, ENO2
6multiple sclerosis29.9GFAP, APOE
7glaucoma29.9NTF4, NUDT6, TTF2
8amyotrophic lateral sclerosis29.9GFAP, NUDT6, CHAT, SYP
9tuberous sclerosis29.9GFAP, DBH, SYP, S100B
10ischemia29.9CKB, CHAT, NTF4, BAG1, NUDT6, GFAP
11choroid plexus papilloma29.8GFAP
12alzheimer's disease29.8CKB, S100B, APOE, SYP, CHAT, CHRM1
13cerebritis10.6
14neuronitis10.4
15internuclear ophthalmoplegia10.4
16ophthalmoplegia10.4
17sagittal sinus thrombosis10.3
18cervicitis10.3
19carotid artery thrombosis10.2
20mutism10.2
21retrograde amnesia10.2
22bacterial meningitis10.2
23hydrocephalus10.2
24hypopituitarism10.2
25meningitis10.2
26hypophosphatemia10.2
27arachnoiditis10.2
28brain edema10.2
29cortical blindness10.2
30hypokalemia10.2
31adult syndrome10.2
32disseminated intravascular coagulation10.2
33intracranial hypertension10.2
34retinitis10.2
35hyperlipidemia type 310.2
36traumatic brain injury10.2
37bone fracture10.1
38transient global amnesia10.1
39prosopagnosia10.1
40lennox-gastaut syndrome10.1
41intracranial aneurysm10.1
42pituitary apoplexy10.1
43intracranial thrombosis10.1
44personality disorder10.1
45pneumonia10.1
46huntington's disease10.0CHAT
47progressive supranuclear palsy10.0APOE
48vascular dementia10.0APOE
49melanotic neuroectodermal tumor10.0SYP
50rhabdoid tumor10.0SYP

Graphical network of the top 20 diseases related to Head Injury:



Diseases related to head injury

Clinical Features for Head Injury

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Drugs & Therapeutics for Head Injury

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Head Injury

Drug clinical trials:

Search ClinicalTrials for Head Injury

Search NIH Clinical Center for Head Injury

Search CenterWatch for Head Injury

Genetic Tests for Head Injury

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Anatomical Context for Head Injury

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Sources:
32MalaCards
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MalaCards organs/tissues related to Head Injury:

32
Brain, Eye

Animal Models for Head Injury or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Head Injury:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053869.4S100B, APOE, FABP7, CHAT, CHRM1, NTF4
2MP:00036318.9ADNP, CKB, APOE, FABP7, SYP, CHAT

Publications for Head Injury

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Genetic Variations for Head Injury

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Expression for genes affiliated with Head Injury

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Head Injury

Search GEO for disease gene expression data for Head Injury.

Pathways for genes affiliated with Head Injury

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Sources:
4Cell Signaling Technology
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Pathways related to Head Injury according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8ENO2, GFAP, DBH, SYP, FABP7, APOE

Compounds for genes affiliated with Head Injury

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 28IUPHAR, 49PharmGKB, 59Tocris Bioscience
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Compounds related to Head Injury according to GeneCards/GeneDecks:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1estrogen4410.7CHAT, GFAP
2edss4410.5S100B, ENO2, APOE
3s 1004410.5ENO2, SYP, S100B, GFAP
4donepezil44 11 2412.5CHRM1, CHAT, APOE
5homovanillic acid44 2411.5ENO2, CHAT, DBH, GFAP
6l-amino acid4410.4S100B, SYP, CHAT, ENO2, DBH
7streptozotocin4410.4APOE, GFAP, NUDT6, SYP
8glutamate4410.4FABP7, CHAT, GFAP, NTF4, CHRM1, CX3CL1
9kainate44 2811.4APOE, CHAT, NUDT6, GFAP, SYP
10nmda44 2811.4APOE, SYP, CHAT, NUDT6, GFAP, NTF4
11dbc-amp4410.4ENO2, GFAP, NUDT6, CHAT, SYP, S100B
12forskolin44 49 1112.4CHAT, CKB, ENO2, GFAP, DBH, NTF4
13reticulin4410.4SYP, S100B, GFAP
14cocaine44 1111.4CHRM1, CHAT, S100B, DBH, GFAP
15dopamine44 28 11 2413.4ENO2, GFAP, DBH, CHRM1, CHAT, NUDT6
16catecholamine4410.4ENO2, S100B, SYP, CHAT, DBH
17nicotine44 49 28 1113.3TTF2, APOE, CHAT, CHRM1, DBH
18hematoxylin4410.3SYP, S100B, GFAP, ENO2
195-hydroxytryptamine4410.3ENO2, CHRM1, DBH, CHAT, GFAP, SYP
20formaldehyde44 2411.3S100B, SYP, DBH, GFAP, ENO2, CHAT
21potassium44 11 2412.2S100B, CKB, ENO2, GFAP, CHRM1, CHAT
22ethanol44 49 11 2413.2NTF4, TTF2, CHRM1, S100B, DBH, GFAP
23paraffin4410.2GFAP, CHAT, SYP, APOE, S100B, ENO2
24acth4410.2SYP, DBH, GFAP, ENO2, S100B
25cyclic amp44 2411.2DBH, GFAP, CHRM1, CHAT, S100B, SYP
26glucose4410.2CHAT, CKB, DBH, NUDT6, CD63, TTF2
27choline44 11 2412.1CHRM1, NTF4, S100B, SYP, CHAT, ENO2
28creatinine4410.1CKB, SYP, IL18BP, TTF2, GFAP, ENO2
29lactate4410.1DBH, S100B, CHAT, NUDT6, CD63, GFAP
30gaba4410.1FABP7, CHAT, CHRM1, CKB, SYP, S100B
31glutamine4410.1CKB, S100B, GFAP, SYP, ENO2, APOE
32testosterone44 59 11 2413.1GFAP, APOE, SYP, CHAT, BAG1, NUDT6
33progesterone44 59 28 11 2414.1GFAP, CHAT, ENO2, TTF2, BAG1, SYP
34silver4410.1GFAP, CHAT, SYP, ENO2
35serine4410.1BAG1, S100B, SYP, DBH, NUDT6, TTF2
36acetylcholine44 49 28 11 2414.1S100B, DBH, SYP, APOE, ENO2, GFAP
37retinoic acid44 2411.0SYP, NTF4, BAG1, NUDT6, GFAP, S100B
38nitric oxide44 11 2412.0SYP, S100B, CHAT, DBH, NUDT6, CD63
39cholesterol44 28 11 2413.0ENO2, TTF2, CD63, SYP, BECN1, GFAP
40iron44 2411.0ENO2, GFAP, TTF2, DBH, S100B, NUDT6
41cysteine4410.0SYP, TTF2, CX3CL1, S100B, DBH, NUDT6
42atp44 2810.9ENO2, CHRM1, S100B, GFAP, BAG1, TTF2
43aspartate449.9S100B, APOE, CHAT, GFAP, ENO2, CKB
44dexamethasone44 49 28 1112.9TTF2, DBH, SYP, S100B, CHAT, GFAP
45alanine449.9ENO2, CKB, S100B, APOE, CHAT, CHRM1
46tyrosine449.8ENO2, NTF4, GFAP, CD63, NUDT6, DBH
47amine449.8SYP, CHAT, DBH, ENO2
48lipid449.8BECN1, ENO2, S100B, TTF2, GFAP, CD63
49vegf449.7APOE, S100B, ENO2, GFAP, TTF2, NUDT6
50calcium44 49 11 2412.6CKB, NUDT6, TTF2, GFAP, ENO2, HRK

GO Terms for genes affiliated with Head Injury

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Sources:
16Gene Ontology
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Cellular components related to Head Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:04302510.2CHAT, FABP7, APOE, S100B

Biological processes related to Head Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuromuscular synaptic transmissionGO:00727410.3CHRM1, CHAT
2regulation of neuronal synaptic plasticityGO:04816810.0APOE, S100B

Molecular functions related to Head Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tau protein bindingGO:04815610.3APOE, S100B

Products for genes affiliated with Head Injury

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Head Injury

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet