MCID: HDN002
MIFTS: 49

Head Injury malady

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Summaries for Head Injury

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MedlinePlus:33 Chances are you've bumped your head before. usually, the injury is minor because your skull is hard and it protects your brain. but other head injuries can be more severe, such as a skull fracture, concussion, or traumatic brain injury. head injuries can be open or closed. a closed injury does not break through the skull. with an open, or penetrating, injury, an object pierces the skull and enters brain tissue. closed injuries are not always less severe than open injuries. some common causes of head injuries are falls, motor vehicle accidents, violence, and sports injuries. it is important to know the warning signs of a moderate or severe head injury. get help immediately if the injured person has a headache that gets worse or does not go away repeated vomiting or nausea convulsions or seizures an inability to wake up dilation of one or both pupils of the eyes slurred speech weakness or numbness in the arms or legs loss of coordination increased confusion, restlessness, or agitation nih: national institute of neurological disorders and stroke

MalaCards based summary: Head Injury, also known as head injuries, is related to choroid plexus papilloma and medulloblastoma. An important gene associated with Head Injury is NTF4 (neurotrophin 4), and among its related pathways are Nuclear signaling by ERBB4 and Neuroscience. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes, and related mouse phenotypes are homeostasis/metabolism and nervous system.

NINDS:43 Traumatic brain injury (TBI), a form of

Wikipedia:65 Any injury that results in trauma to the skull, or brain can be classified as a head injury. The terms... more...

Aliases & Classifications for Head Injury

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Related Diseases for Head Injury

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Diseases related to Head Injury via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 180)
idRelated DiseaseScoreTop Affiliating Genes
1choroid plexus papilloma30.6GFAP
2medulloblastoma30.2NUDT6, GFAP, S100B
3tuberous sclerosis30.1GFAP, S100B
4parkinson's disease30.0APOE, CHAT, NTF4, NUDT6
5memory impairment29.9APOE, CHAT
6dementia29.8CHRM1, CHAT, APOE, GFAP
7ischemia29.6NUDT6, GFAP, CHAT, NTF4
8alzheimer's disease28.5NTF4, NUDT6, GFAP, APOE, CHRM1, CHAT
9cerebritis10.7
10traumatic brain injury10.6
11brain injury10.5
12subependymal giant cell astrocytoma10.4GFAP
13internuclear ophthalmoplegia10.4
14neuronitis10.4
15ophthalmoplegia10.4
16giant cell glioblastoma10.4GFAP
17sagittal sinus thrombosis10.4
18cervicitis10.4
19shaken baby syndrome10.4
20headache10.3
21blindness10.3
22lewy body dementia10.3APOE
23hydrocephalus10.3
24hypertension10.3
25retrograde amnesia10.3
26mutism10.3
27bacterial meningitis10.3
28hypopituitarism10.3
29meningitis10.3
30arachnoid cysts10.3
31aneurysm10.3
32seizure disorder10.3
33myxopapillary ependymoma10.3GFAP, S100B
34papillary ependymoma10.2S100B, GFAP
35choroid plexus carcinoma10.2GFAP, S100B
36gemistocytic astrocytoma10.2GFAP, S100B
37anaplastic ependymoma10.2S100B, GFAP
38pineocytoma10.2S100B, GFAP
39syringoma10.2S100B, GFAP
40myoepithelioma10.2S100B, GFAP
41hemangioblastoma10.2GFAP, S100B
42chordoma10.2S100B, GFAP
43ganglioglioma10.2S100B, GFAP
44cortical blindness10.2
45hypokalemia10.2
46hypophosphatemia10.2
47arachnoiditis10.2
48brain edema10.2
49carotid artery thrombosis10.2
50disseminated intravascular coagulation10.2

Graphical network of the top 20 diseases related to Head Injury:



Diseases related to head injury

Symptoms for Head Injury

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Drugs & Therapeutics for Head Injury

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Drug clinical trials:

Search ClinicalTrials for Head Injury

Search NIH Clinical Center for Head Injury

Genetic Tests for Head Injury

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Anatomical Context for Head Injury

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MalaCards organs/tissues related to Head Injury:

32
Brain, Eye, Testes, Pituitary, Endothelial, Bone, Neutrophil, T cells, Cortex, Spinal cord, Heart, Prostate

Animal Models for Head Injury or affiliated genes

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MGI Mouse Phenotypes related to Head Injury:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7FABP7, CHAT, CHRM1, APOE, GFAP
2MP:00036317.0GFAP, APOE, CHRM1, CHAT, FABP7, NTF4
3MP:00053866.8S100B, GFAP, APOE, CHRM1, CHAT, FABP7

Publications for Head Injury

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Articles related to Head Injury:

(show top 50)    (show all 720)
idTitleAuthorsYear
1
Head Injury in Children: Has a Change in Circumstances Caused an Increase in Treatment Numbers? (25370862)
2014
2
Visualisation of the intact dura mater and brain surface in infant autopsies: a minimally destructive technique for the post-mortem assessment of head injury. (25384986)
2014
3
Imaging of pediatric head injury in the emergency department. (25272077)
2014
4
Ischemic retinopathy and neovascular proliferation secondary to severe head injury. (25143848)
2014
5
Head injury. (23431655)
2013
6
Batting head injury in professional cricket: a systematic video analysis of helmet safety characteristics. (23418269)
2013
7
Pneumonia in patients with severe head injury: incidence, risk factors, and outcomes. (23157183)
2013
8
Predicting mortality from head injury: experience of Sancti SpA-ritus province, Cuba. (23934424)
2013
9
Late-onset sensorineural hearing loss due to congenital cytomegalovirus infection: could head injury be a trigger? (23025246)
2013
10
Epidemiology of paediatric minor head injury: Comparison of injury characteristics with Indices of Multiple Deprivation. (23958554)
2013
11
Urgent intracranial carotid artery decompression after penetrating head injury. (23634269)
2013
12
Early postinjury exercise reverses memory deficits and retards the progression of closed-head injury in mice. (23184513)
2013
13
Computed tomography after decompressive craniectomy for head injury. (23564139)
2013
14
Delayed neurological deterioration after mild head injury: cause, temporal course, and outcomes. (23867298)
2013
15
Susceptibility of the MMPI-2-RF Neurological Complaints and Cognitive Complaints Scales to Over-reporting in Simulated Head Injury. (24191968)
2013
16
Annals of Emergency Medicine Journal Club. Biomarkers revisited: study design, validity, and STARD: Will S100-B affect computed tomography use in head injury patients?: Answers to the March 2012 Journal Club questions. (22818373)
2012
17
Role of hyperbaric oxygen therapy in severe head injury in children. (22837768)
2012
18
Carotid artery dissection presenting with isolated headache and Horner syndrome after minor head injury. (22633727)
2012
19
In vivo bioluminescent imaging of a new model of infectious complications in head-injury rats. (21806472)
2012
20
Head injury or head motion? Assessment and quantification of motion artifacts in diffusion tensor imaging studies. (21391258)
2012
21
Serum levels of protein S100B predict intracranial lesions in mild head injury. (22285378)
2012
22
Predicting the need for CT imaging in children with minor head injury using an ensemble of Naive Bayes classifiers. (22196718)
2012
23
Chest injuries associated with head injury. (24027384)
2012
24
A microdialysis study of oral vigabatrin administration in head injury patients: preliminary evaluation of multimodality monitoring. (22327707)
2012
25
Outcome analysis and outcome predictors of traumatic head injury in childhood: Analysis of 454 observations. (21769206)
2011
26
Clinical decision rules for children with minor head injury: a systematic review. (21310894)
2011
27
Tectorial membrane injury: frequently overlooked in pediatric traumatic head injury. (21852371)
2011
28
Comparative yield of positive brain computed tomography after implementing the NICE or SIGN head injury guidelines in two equivalent urban populations. (21296343)
2011
29
Controversial treatment of a victim of severe head injury complicated by septic shock and acute respiratory distress syndrome. (23754904)
2011
30
Head injury causation scenarios for belted, rear-seated children in frontal impacts. (21259175)
2011
31
Prognostic value of magnetic resonance imaging in moderate and severe head injury: a prospective study of early MRI findings and one-year outcome. (21401308)
2011
32
White-eyed medial wall blowout fracture mimicking head injury due to persistent oculocardiac reflex. (21959489)
2011
33
Permanent post-concussion symptoms after mild head injury. (21401372)
2011
34
Coagulopathy in moderate head injury. The role of early administration of low molecular weight heparin. (20642324)
2010
35
Six nails in the head: multiple pneumatic nail gun head injury. (20726759)
2010
36
CATCH: a clinical decision rule for the use of computed tomography in children with minor head injury. (20142371)
2010
37
Automated assessment of midline shift in head injury patients. (20663606)
2010
38
Cerebellar infarction after head injury. (20606808)
2010
39
Severe head injury: control of physiological variables, organ failure and complications in the intensive care unit. (17711565)
2007
40
Oxidative damage after severe head injury and its relationship to neurological outcome. (12234402)
2002
41
Anterior hypopituitarism with unusual delayed onset of diabetes insipidus after penetrating head injury. (12362120)
2002
42
Soluble adhesion molecules in CSF are increased in children with severe head injury. (9814634)
1998
43
Transient global amnesia triggered by mild head injury. (9653523)
1998
44
Motor and cognitive deficits in apolipoprotein E-deficient mice after closed head injury. (9284075)
1997
45
HM-PAO-SPECT in persistent vegetative state after head injury: prognostic indicator of the likelihood of recovery? (2071761)
1991
46
Severe head injury: effect upon cellular immune function. (1675441)
1991
47
Accommodative esotropia after ocular and head injury. (2301531)
1990
48
Paroxysmal choreoathetosis after head injury. (3746316)
1986
49
Internal carotid artery thrombosis secondary to closed head injury. (5434376)
1970
50
Intracranial thrombosis of the internal carotid artery after closed head injury. (5360046)
1969

Variations for Head Injury

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Expression for genes affiliated with Head Injury

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Expression patterns in normal tissues for genes affiliated with Head Injury

Search GEO for disease gene expression data for Head Injury.

Pathways for genes affiliated with Head Injury

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Pathways related to Head Injury according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5S100B, GFAP
28.3S100B, FABP7, APOE, GFAP

Compounds for genes affiliated with Head Injury

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Compounds related to Head Injury according to GeneCards/GeneDecks:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1eosin449.9S100B, GFAP
2s 100449.9GFAP, S100B
32,3-cyclic nucleotide449.8S100B, GFAP
4reticulin449.8S100B, GFAP
5propentofylline449.7GFAP, CHAT
6edss449.6APOE, S100B
7scopolamine44 28 24 1112.6CHAT, CHRM1
8pirenzepine44 28 1111.5CHRM1, CHAT
9homovanillic acid44 2410.5GFAP, CHAT
10quinolinic acid44 2410.4GFAP, CHAT, NTF4
11bromodeoxyuridine449.3NUDT6, GFAP, S100B
12benzodiazepine449.3CHAT, GFAP
13formaldehyde44 2410.2CHAT, GFAP, S100B
145-hydroxytryptamine449.2CHAT, CHRM1, GFAP
15l-amino acid449.1S100B, CHAT
16adenylate449.1GFAP, S100B, NTF4, CHRM1
17streptozotocin449.0NUDT6, GFAP, APOE
18donepezil44 50 24 1112.0APOE, CHRM1, CHAT
19olanzapine44 50 28 24 1113.0APOE, CHAT, CHRM1
20methionine448.9S100B, NUDT6, GFAP
21cocaine44 119.9S100B, CHAT, CHRM1, GFAP
22potassium44 24 1110.8CHRM1, S100B, CHAT, GFAP
23nicotine44 28 50 1111.8CHRM1, APOE, CHAT
24dbc-amp448.8NUDT6, GFAP, S100B, CHAT
25cyclic amp44 249.8CHAT, GFAP, S100B, CHRM1
26lactate448.8CHAT, GFAP, NUDT6, S100B
27phosphatidylinositol448.7NUDT6, CHRM1, CHAT, NTF4
28ethanol44 50 24 1111.6NTF4, CHRM1, S100B, CHAT, GFAP
29gaba448.5CHRM1, GFAP, S100B, CHAT, FABP7
30nitric oxide44 24 1110.5CHRM1, CHAT, S100B, NUDT6
31paraffin448.5CHAT, APOE, GFAP, S100B
32forskolin44 50 1110.5GFAP, NUDT6, CHAT, NTF4, S100B
33aspartate448.4CHAT, APOE, GFAP, S100B
34vegf448.4NUDT6, S100B, GFAP, APOE
35kainate44 289.4GFAP, NUDT6, CHAT, APOE
36atp44 289.3NUDT6, GFAP, CHRM1, CHAT, S100B
37serine448.1APOE, GFAP, NUDT6, NTF4, S100B
38estrogen448.1S100B, APOE, GFAP, CHAT
39retinoic acid44 249.1S100B, CHAT, NTF4, GFAP, NUDT6, FABP7
40nmda44 289.1NUDT6, CHAT, NTF4, APOE, GFAP
41choline44 24 1110.0NTF4, GFAP, CHRM1, S100B, CHAT, NUDT6
42tyrosine448.0CHRM1, NUDT6, S100B, NTF4, CHAT, GFAP
43testosterone44 61 24 1111.0GFAP, APOE, CHAT, S100B, NUDT6
44calcium44 50 24 1111.0S100B, NTF4, CHAT, CHRM1, NUDT6, GFAP
45arginine447.8S100B, NTF4, NUDT6, GFAP, APOE, CHRM1
46alanine447.7S100B, CHRM1, NTF4, GFAP, APOE, CHAT
47lipid447.7S100B, FABP7, CHAT, CHRM1, APOE, GFAP
48dopamine44 28 24 1110.6GFAP, APOE, CHRM1, CHAT, S100B, NUDT6
49acetylcholine44 50 28 24 1111.2CHAT, CHRM1, GFAP, NUDT6, NTF4, S100B
50glutamate446.9APOE, GFAP, CHRM1, CHAT, FABP7, NTF4

GO Terms for genes affiliated with Head Injury

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Cellular components related to Head Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430258.2S100B, FABP7, CHAT, APOE

Biological processes related to Head Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1long-term synaptic potentiationGO:0602919.5S100B, GFAP
2regulation of neuronal synaptic plasticityGO:0481689.1S100B, APOE
3neuromuscular synaptic transmissionGO:0072749.1CHAT, CHRM1

Molecular functions related to Head Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tau protein bindingGO:0481569.2S100B, APOE

Products for genes affiliated with Head Injury

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Sources for Head Injury

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet