MCID: HDN002
MIFTS: 49

Head Injury malady

Summaries for Head Injury

Sources:
34MedlinePlus, 44NINDS, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Chances are you've bumped your head before. usually, the injury is minor because your skull is hard and it protects your brain. but other head injuries can be more severe, such as a skull fracture, concussion, or traumatic brain injury. head injuries can be open or closed. a closed injury does not break through the skull. with an open, or penetrating, injury, an object pierces the skull and enters brain tissue. closed injuries are not always less severe than open injuries. some common causes of head injuries are falls, motor vehicle accidents, violence, and sports injuries. it is important to know the warning signs of a moderate or severe head injury. get help immediately if the injured person has a headache that gets worse or does not go away repeated vomiting or nausea convulsions or seizures an inability to wake up dilation of one or both pupils of the eyes slurred speech weakness or numbness in the arms or legs loss of coordination increased confusion, restlessness, or agitation nih: national institute of neurological disorders and stroke

MalaCards: Head Injury, also known as head injuries, is related to persistent vegetative state and parkinson's disease. An important gene associated with Head Injury is NTF4 (neurotrophin 4), and among its related pathways is Neuroscience. The compounds estrogen and edss have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and spinal cord, and related mouse phenotypes are behavior/neurological and nervous system.

NINDS:44 Traumatic brain injury (TBI), a form of

Wikipedia:64 Any injury that results in trauma to the scalp, skull, or brain can be classified as a head injury. The... more...

Aliases & Classifications for Head Injury

Sources:
44NINDS, 34MedlinePlus, 25ICD10
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Related Diseases for Head Injury

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Head Injury via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 202)
idRelated DiseaseScoreTop Affiliating Genes
1persistent vegetative state30.2ENO2
2parkinson's disease30.2NUDT6, DBH, NTF4, CHAT, APOE
3amyotrophic lateral sclerosis29.9GFAP, NUDT6, CHAT, SYP
4tuberous sclerosis29.9GFAP, DBH, SYP, S100B
5choroid plexus papilloma29.9GFAP
6brain injury10.8
7traumatic brain injury10.6
8n syndrome10.4
9internuclear ophthalmoplegia10.4
10shaken baby syndrome10.4
11sagittal sinus thrombosis10.3
12headache10.3
13carotid artery thrombosis10.2
14mutism10.2
15retrograde amnesia10.2
16bacterial meningitis10.2
17arachnoid cysts10.2
18hypophosphatemia10.2
19brain edema10.2
20cortical blindness10.2
21hypokalemia10.2
22adult syndrome10.2
23hyperlipidemia type 310.2
24post-traumatic epilepsy10.2
25cerebral atrophy10.2
26seizure disorder10.2
27blindness10.2
28bone fracture10.1
29transient global amnesia10.1
30prosopagnosia10.1
31lennox-gastaut syndrome10.1
32intracranial aneurysm10.1
33pituitary apoplexy10.1
34cluster headache10.1
35paroxysmal choreoathetosis10.1
36memory impairment10.1
37huntington's disease10.0CHAT
38progressive supranuclear palsy10.0APOE
39vascular dementia10.0APOE
40melanotic neuroectodermal tumor10.0SYP
41rhabdoid tumor10.0SYP
42cerebral primitive neuroectodermal tumor10.0ENO2
43dysembryoplastic neuroepithelial tumor10.0SYP
44giant cell glioblastoma10.0GFAP
45bipolar disorder10.0DBH
46attention deficit hyperactivity disorder10.0DBH
47gliosarcoma10.0GFAP
48myocardial infarction10.0APOE, CKB
49multiple sclerosis10.0GFAP, APOE
50sarcoma10.0S100B, ENO2

Graphical network of the top 20 diseases related to Head Injury:



Diseases related to head injury

Clinical Features for Head Injury

Drugs & Therapeutics for Head Injury

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Head Injury

Drug clinical trials:

Search ClinicalTrials for Head Injury

Search NIH Clinical Center for Head Injury

Search CenterWatch for Head Injury

Genetic Tests for Head Injury

Anatomical Context for Head Injury

Sources:
33MalaCards
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MalaCards organs/tissues related to Head Injury:

33
Brain, Cortex, Spinal cord, Heart, T cells, B cells, Endothelial, Fetal brain, Parietal lobe, Temporal lobe, Occipital lobe, Pituitary

Animal Models for Head Injury or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Head Injury:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053869.4S100B, APOE, FABP7, CHAT, CHRM1, NTF4
2MP:00036318.9ADNP, CKB, APOE, FABP7, SYP, CHAT

Publications for Head Injury

Sources:
51PubMed
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Articles related to Head Injury:

(show top 50)    (show all 727)
idTitleAuthorsYear
1
Pneumonia in patients with severe head injury: incidence, risk factors, and outcomes. (23157183)
2013
2
Early postinjury exercise reverses memory deficits and retards the progression of closed-head injury in mice. (23184513)
2013
3
Head injury and risk of Parkinson disease: a systematic review and meta-analysis. (23609436)
2013
4
Microglial inhibitory effect of ginseng ameliorates cognitive deficits and neuroinflammation following traumatic head injury in rats. (24052247)
2013
5
Minor head injury in the elderly at very low risk: a retrospective study of 6 years in an Emergency Department (ED). (22867821)
2013
6
Fatal penetrating head injury by bamboo fragments. (23067800)
2013
7
Association Between Infantile Spasms and Nonaccidental Head Injury. (23580697)
2013
8
Triggers for head computed tomography following paediatric head injury: Comparison of physicians' reported practice and clinical decision rules. (23379456)
2013
9
The usefulness of brain magnetic resonance imaging with mild head injury and the negative findings of brain computed tomography. (24175023)
2013
10
Effects of selective and non-selective cyclooxygenase inhibition against neurological deficit and brain oedema following closed head injury in mice. (23122881)
2013
11
Chest injuries associated with head injury. (24027384)
2012
12
Implementation of adapted PECARN decision rule for children with minor head injury in the pediatric emergency department. (22724450)
2012
13
Towards development of a survival prediction tool for pediatric head injury. (22922420)
2012
14
Seizures after head injury. (22450453)
2012
15
Epidemiology of traumatic head injury in Korean children. (22468109)
2012
16
Effects of neurosurgical treatment and severity of head injury on cognitive functioning, general health and incidence of mental disorders in patients with traumatic brain injury. (24396755)
2012
17
Effect of mannitol on cerebral blood volume in patients with head injury. (22089753)
2012
18
S100-B protein as a screening tool for the early assessment of minor head injury. (21944878)
2012
19
The role of anxiety sensitivity in symptom perception after minor head injury: an exploratory study. (22077534)
2011
20
Development of head injury assessment reference values based on NASA injury modeling. (22869304)
2011
21
Analysis of different decision aids for clinical use in pediatric head injury in an emergency department of a general hospital. (20495492)
2011
22
Outcome of head injury patients undergoing surgical management: a tertiary level experience. (22710539)
2011
23
External validation of the New Orleans Criteria (NOC), the Canadian CT Head Rule (CCHR) and the National Emergency X-Radiography Utilization Study II (NEXUS II) for CT scanning in pediatric patients with minor head injury in a non-trauma center. (21465153)
2011
24
Vestibular and stabilometric findings in whiplash injury and minor head trauma. (22323849)
2011
25
Impairments in learning, memory, and metamemory following childhood head injury. (21552068)
2011
26
Sudden death following cranioplasty: a complication of decompressive craniectomy for head injury. (22115018)
2011
27
Progressive osteolytic calvarial lesions in children after minor head injury. (21893940)
2011
28
Factors associated with clinically significant head injury in children involved in motor vehicle crashes. (21128190)
2010
29
Association of ALS with head injury, cigarette smoking and APOE genotypes. (20129626)
2010
30
Antibodies to dynorphin a (1-17) attenuate closed head injury induced blood-brain barrier disruption, brain edema formation and brain pathology in the rat. (19812968)
2010
31
Scheduled repeat CT scanning for traumatic brain injury remains important in assessing head injury progression. (20421059)
2010
32
Pulse wave velocity in patients with severe head injury a pilot study. (21096058)
2010
33
Verbal memory impairment in severe closed head injury: the role of encoding and consolidation. (20175012)
2010
34
Brain SPECT and Neuropsychological Examination in Patients with a History of Minor Craniocerebral Trauma Nine Years after Head Injury. (24148328)
2010
35
Critically ill head injury patients and nutritional issues; need for rural guidelines. (20726186)
2010
36
Clinical factors associated with intracranial complications after pediatric traumatic head injury: an observational study of children submitted to a neurosurgical referral unit. (20664236)
2010
37
Readability of information leaflets given to attenders at hospital with a head injury. (20385679)
2010
38
Clinical analysis of spinal cord injury with or without cervical ossification of the posterior longitudinal ligament, spondylosis, and canal stenosis in elderly head injury patients. (20587969)
2010
39
Racial disparities in health care-emergency department management of minor head injury. (20157466)
2009
40
Retinal folds and retinoschisis in accidental and non-accidental head injury. (18636080)
2008
41
Cerebral endothelial damage after severe head injury. (17965526)
2007
42
New onset migraine with aura following head injury: a case report. (15546273)
2004
43
Caspase-8 expression and proteolysis in human brain after severe head injury. (12738800)
2003
44
Oxidative damage after severe head injury and its relationship to neurological outcome. (12234402)
2002
45
Serum S100B concentrations are increased after closed head injury in children: a preliminary study. (12490005)
2002
46
Soluble adhesion molecules in CSF are increased in children with severe head injury. (9814634)
1998
47
Modified hormonal effects on fat metabolism after severe head injury in children. (8725263)
1996
48
Paroxysmal choreoathetosis after head injury. (3746316)
1986
49
Internuclear ophthalmoplegia following head injury. (7359205)
1980
50
Argyll-Robertson Pupil due to Head Injury. (19986876)
1929

Genetic Variations for Head Injury

Expression for genes affiliated with Head Injury

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Head Injury

Search GEO for disease gene expression data for Head Injury.

Pathways for genes affiliated with Head Injury

Sources:
4Cell Signaling Technology
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Pathways related to Head Injury according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8ENO2, GFAP, DBH, SYP, FABP7, APOE

Compounds for genes affiliated with Head Injury

Sources:
45Novoseek, 11DrugBank, 24HMDB, 29IUPHAR, 50PharmGKB, 60Tocris Bioscience
See all sources

Compounds related to Head Injury according to GeneCards/GeneDecks:

(show top 50)    (show all 85)
idCompoundScoreTop Affiliating Genes
1estrogen4510.7CHAT, GFAP
2edss4510.5S100B, APOE, ENO2
3s 1004510.5S100B, SYP, GFAP, ENO2
4donepezil45 11 2412.5APOE, CHAT, CHRM1
5homovanillic acid45 2411.5CHAT, DBH, GFAP, ENO2
6l-amino acid4510.4S100B, SYP, CHAT, DBH, ENO2
7streptozotocin4510.4APOE, SYP, NUDT6, GFAP
8glutamate4510.4FABP7, CHAT, CHRM1, NTF4, CX3CL1, GFAP
9kainate45 2911.4APOE, SYP, CHAT, NUDT6, GFAP
10nmda45 2911.4APOE, SYP, CHAT, NTF4, NUDT6, GFAP
11dbc-amp4510.4S100B, SYP, CHAT, NUDT6, GFAP, ENO2
12forskolin45 50 1112.4CKB, CHAT, NTF4, DBH, GFAP, ENO2
13reticulin4510.4GFAP, SYP, S100B
14catecholamine4510.4S100B, SYP, CHAT, DBH, ENO2
15cocaine45 1111.4S100B, CHAT, CHRM1, DBH, GFAP
16dopamine45 29 11 2413.4CHAT, CHRM1, DBH, NUDT6, GFAP, ENO2
17nicotine45 50 29 1113.3APOE, CHAT, CHRM1, DBH, TTF2
18hematoxylin4510.3S100B, SYP, GFAP, ENO2
195-hydroxytryptamine4510.3SYP, CHAT, CHRM1, DBH, GFAP, ENO2
20formaldehyde45 2411.3S100B, SYP, CHAT, DBH, GFAP, ENO2
21potassium45 11 2412.2CKB, S100B, SYP, CHAT, CHRM1, GFAP
22ethanol45 50 11 2413.2S100B, SYP, CHAT, CHRM1, NTF4, DBH
23paraffin4510.2S100B, APOE, SYP, CHAT, GFAP, ENO2
24acth4510.2S100B, SYP, DBH, GFAP, ENO2
25cyclic amp45 2411.2CKB, S100B, SYP, CHAT, CHRM1, DBH
26glucose4510.2CKB, CHAT, DBH, NUDT6, CD63, TTF2
27choline45 11 2412.1ENO2, S100B, SYP, CHAT, CHRM1, NTF4
28creatinine4510.1CKB, S100B, APOE, SYP, IL18BP, TTF2
29lactate4510.1CKB, S100B, CHAT, DBH, NUDT6, CD63
30gaba4510.1CKB, S100B, FABP7, SYP, CHAT, CHRM1
31glutamine4510.1CKB, S100B, APOE, SYP, GFAP, ENO2
32testosterone45 60 11 2413.1S100B, APOE, SYP, CHAT, BAG1, NUDT6
33progesterone45 60 29 11 2414.1CKB, S100B, SYP, CHAT, BAG1, TTF2
34silver4510.1SYP, CHAT, GFAP, ENO2
35serine4510.1S100B, SYP, BAG1, DBH, NUDT6, TTF2
36acetylcholine45 50 29 11 2414.1S100B, APOE, SYP, CHAT, CHRM1, NTF4
37retinoic acid45 2411.0S100B, FABP7, SYP, CHAT, NTF4, BAG1
38nitric oxide45 11 2412.0S100B, SYP, CHAT, CHRM1, DBH, NUDT6
39cholesterol45 29 11 2413.0APOE, SYP, CD63, TTF2, GFAP, ENO2
40iron45 2411.0S100B, DBH, NUDT6, TTF2, GFAP, ENO2
41cysteine4510.0S100B, APOE, SYP, DBH, NUDT6, CX3CL1
42atp45 2910.9CKB, S100B, CHAT, CHRM1, BAG1, NUDT6
43aspartate459.9ENO2, GFAP, CHAT, APOE, S100B, CKB
44dexamethasone45 50 29 1112.9S100B, SYP, CHAT, DBH, TTF2, GFAP
45alanine459.9CKB, S100B, APOE, CHAT, CHRM1, NTF4
46tyrosine459.8S100B, SYP, CHAT, CHRM1, NTF4, BAG1
47amine459.8SYP, CHAT, DBH, ENO2
48lipid459.8CHAT, SYP, FABP7, APOE, S100B, CHRM1
49vegf459.7S100B, APOE, SYP, NUDT6, TTF2, GFAP
50calcium45 50 11 2412.6NTF4, CHRM1, CHAT, SYP, S100B, CKB

GO Terms for genes affiliated with Head Injury

Sources:
16Gene Ontology
See all sources

Cellular components related to Head Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:04302510.2CHAT, FABP7, APOE, S100B

Biological processes related to Head Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuromuscular synaptic transmissionGO:00727410.3CHRM1, CHAT
2regulation of neuronal synaptic plasticityGO:04816810.0APOE, S100B

Molecular functions related to Head Injury according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1tau protein bindingGO:04815610.3APOE, S100B

Products for genes affiliated with Head Injury

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Head Injury

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet