Summaries for Head Injury

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MedlinePlus:32 Chances are you've bumped your head before. usually, the injury is minor because your skull is hard and it protects your brain. but other head injuries can be more severe, such as a skull fracture, concussion, or traumatic brain injury. head injuries can be open or closed. a closed injury does not break through the skull. with an open, or penetrating, injury, an object pierces the skull and enters brain tissue. closed injuries are not always less severe than open injuries. some common causes of head injuries are falls, motor vehicle accidents, violence, and sports injuries. it is important to know the warning signs of a moderate or severe head injury. get help immediately if the injured person has a headache that gets worse or does not go away repeated vomiting or nausea convulsions or seizures an inability to wake up dilation of one or both pupils of the eyes slurred speech weakness or numbness in the arms or legs loss of coordination increased confusion, restlessness, or agitation nih: national institute of neurological disorders and stroke

MalaCards based summary: Head Injury, also known as head injuries, is related to choroid plexus papilloma and medulloblastoma. An important gene associated with Head Injury is NTF4 (neurotrophin 4), and among its related pathways are Nuclear signaling by ERBB4 and Neuroscience. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes, and related mouse phenotypes are homeostasis/metabolism and nervous system.

NINDS:42 Traumatic brain injury (TBI), a form of

Wikipedia:63 Any injury that results in trauma to the skull, or brain can be classified as a head injury. The terms... more...

Aliases & Classifications for Head Injury

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Related Diseases for Head Injury

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Diseases related to Head Injury via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 174)
idRelated DiseaseScoreTop Affiliating Genes
1choroid plexus papilloma30.5GFAP
2medulloblastoma30.2S100B, GFAP, NUDT6
3tuberous sclerosis30.1S100B, GFAP
4dementia29.8CHAT, CHRM1, APOE, GFAP
5ischemia29.6NUDT6, GFAP, CHAT, NTF4
6cerebritis10.7
7traumatic brain injury10.6
8brain injury10.5
9neuronitis10.4
10subependymal giant cell astrocytoma10.4GFAP
11internuclear ophthalmoplegia10.4
12ophthalmoplegia10.4
13cervicitis10.4
14giant cell glioblastoma10.4GFAP
15sagittal sinus thrombosis10.4
16shaken baby syndrome10.4
17mutism10.3
18headache10.3
19blindness10.3
20hydrocephalus10.3
21retrograde amnesia10.3
22bacterial meningitis10.3
23hypopituitarism10.3
24meningitis10.3
25arachnoid cysts10.3
26aneurysm10.3
27seizure disorder10.3
28dementia, lewy body10.3APOE
29myxopapillary ependymoma10.2S100B, GFAP
30papillary ependymoma10.2GFAP, S100B
31choroid plexus carcinoma10.2S100B, GFAP
32anaplastic ependymoma10.2GFAP, S100B
33gemistocytic astrocytoma10.2GFAP, S100B
34syringoma10.2GFAP, S100B
35pineocytoma10.2GFAP, S100B
36myoepithelioma10.2S100B, GFAP
37hemangioblastoma10.2GFAP, S100B
38cortical blindness10.2
39hypokalemia10.2
40hypophosphatemia10.2
41carotid artery thrombosis10.2
42arachnoiditis10.2
43brain edema10.2
44disseminated intravascular coagulation10.2
45intracranial hypertension10.2
46retinitis10.2
47hyperlipidemia type 310.2
48post-traumatic epilepsy10.2
49cerebral atrophy10.2
50persistent vegetative state10.2

Graphical network of the top 20 diseases related to Head Injury:



Diseases related to head injury

Symptoms for Head Injury

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Drugs & Therapeutics for Head Injury

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Drug clinical trials:

Search ClinicalTrials for Head Injury

Search NIH Clinical Center for Head Injury

Genetic Tests for Head Injury

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Anatomical Context for Head Injury

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MalaCards organs/tissues related to Head Injury:

31
Brain, Eye, Testes, Pituitary, Endothelial, Bone, Neutrophil, T cells, Cortex, Spinal cord, Heart, Prostate

Animal Models for Head Injury or affiliated genes

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MGI Mouse Phenotypes related to Head Injury:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7FABP7, CHAT, CHRM1, APOE, GFAP
2MP:00036317.0GFAP, APOE, CHRM1, CHAT, FABP7, NTF4
3MP:00053866.8S100B, GFAP, APOE, CHRM1, CHAT, FABP7

Publications for Head Injury

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Articles related to Head Injury:

(show top 50)    (show all 741)
idTitleAuthorsYear
1
Brief account on the head injury of a noble youngster in the sixteenth century (Prince Don Carlos, heir to Philip II of Spain, 1545-1568). (25837577)
2015
2
Head injury and risk for Parkinson disease: Results from a Danish case-control study. (25681453)
2015
3
Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment. (25904805)
2015
4
Head Injury in Children: Has a Change in Circumstances Caused an Increase in Treatment Numbers? (25370862)
2014
5
Visualisation of the intact dura mater and brain surface in infant autopsies: a minimally destructive technique for the post-mortem assessment of head injury. (25384986)
2014
6
Imaging of pediatric head injury in the emergency department. (25272077)
2014
7
Head injury. (23431655)
2013
8
Batting head injury in professional cricket: a systematic video analysis of helmet safety characteristics. (23418269)
2013
9
Pneumonia in patients with severe head injury: incidence, risk factors, and outcomes. (23157183)
2013
10
Predicting mortality from head injury: experience of Sancti SpA-ritus province, Cuba. (23934424)
2013
11
Late-onset sensorineural hearing loss due to congenital cytomegalovirus infection: could head injury be a trigger? (23025246)
2013
12
An analysis of predictive markers for intracranial haemorrhage in warfarinised head injury patients. (22362648)
2013
13
Epidemiology of paediatric minor head injury: Comparison of injury characteristics with Indices of Multiple Deprivation. (23958554)
2013
14
Urgent intracranial carotid artery decompression after penetrating head injury. (23634269)
2013
15
Early postinjury exercise reverses memory deficits and retards the progression of closed-head injury in mice. (23184513)
2013
16
Computed tomography after decompressive craniectomy for head injury. (23564139)
2013
17
Delayed neurological deterioration after mild head injury: cause, temporal course, and outcomes. (23867298)
2013
18
Annals of Emergency Medicine Journal Club. Biomarkers revisited: study design, validity, and STARD: Will S100-B affect computed tomography use in head injury patients?: Answers to the March 2012 Journal Club questions. (22818373)
2012
19
Role of hyperbaric oxygen therapy in severe head injury in children. (22837768)
2012
20
Carotid artery dissection presenting with isolated headache and Horner syndrome after minor head injury. (22633727)
2012
21
In vivo bioluminescent imaging of a new model of infectious complications in head-injury rats. (21806472)
2012
22
Head injury or head motion? Assessment and quantification of motion artifacts in diffusion tensor imaging studies. (21391258)
2012
23
Serum levels of protein S100B predict intracranial lesions in mild head injury. (22285378)
2012
24
Predicting the need for CT imaging in children with minor head injury using an ensemble of Naive Bayes classifiers. (22196718)
2012
25
Chest injuries associated with head injury. (24027384)
2012
26
A microdialysis study of oral vigabatrin administration in head injury patients: preliminary evaluation of multimodality monitoring. (22327707)
2012
27
Outcome analysis and outcome predictors of traumatic head injury in childhood: Analysis of 454 observations. (21769206)
2011
28
Clinical decision rules for children with minor head injury: a systematic review. (21310894)
2011
29
Tectorial membrane injury: frequently overlooked in pediatric traumatic head injury. (21852371)
2011
30
Comparative yield of positive brain computed tomography after implementing the NICE or SIGN head injury guidelines in two equivalent urban populations. (21296343)
2011
31
Controversial treatment of a victim of severe head injury complicated by septic shock and acute respiratory distress syndrome. (23754904)
2011
32
Head injury causation scenarios for belted, rear-seated children in frontal impacts. (21259175)
2011
33
Prognostic value of magnetic resonance imaging in moderate and severe head injury: a prospective study of early MRI findings and one-year outcome. (21401308)
2011
34
White-eyed medial wall blowout fracture mimicking head injury due to persistent oculocardiac reflex. (21959489)
2011
35
Coagulopathy in moderate head injury. The role of early administration of low molecular weight heparin. (20642324)
2010
36
Six nails in the head: multiple pneumatic nail gun head injury. (20726759)
2010
37
CATCH: a clinical decision rule for the use of computed tomography in children with minor head injury. (20142371)
2010
38
Automated assessment of midline shift in head injury patients. (20663606)
2010
39
Severe head injury: control of physiological variables, organ failure and complications in the intensive care unit. (17711565)
2007
40
Oxidative damage after severe head injury and its relationship to neurological outcome. (12234402)
2002
41
Anterior hypopituitarism with unusual delayed onset of diabetes insipidus after penetrating head injury. (12362120)
2002
42
Soluble adhesion molecules in CSF are increased in children with severe head injury. (9814634)
1998
43
Transient global amnesia triggered by mild head injury. (9653523)
1998
44
Motor and cognitive deficits in apolipoprotein E-deficient mice after closed head injury. (9284075)
1997
45
HM-PAO-SPECT in persistent vegetative state after head injury: prognostic indicator of the likelihood of recovery? (2071761)
1991
46
Severe head injury: effect upon cellular immune function. (1675441)
1991
47
Accommodative esotropia after ocular and head injury. (2301531)
1990
48
Paroxysmal choreoathetosis after head injury. (3746316)
1986
49
Internal carotid artery thrombosis secondary to closed head injury. (5434376)
1970
50
Intracranial thrombosis of the internal carotid artery after closed head injury. (5360046)
1969

Variations for Head Injury

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Expression for genes affiliated with Head Injury

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Search GEO for disease gene expression data for Head Injury.

Pathways for genes affiliated with Head Injury

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Pathways related to Head Injury according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5S100B, GFAP
28.3S100B, FABP7, APOE, GFAP

Compounds for genes affiliated with Head Injury

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Compounds related to Head Injury according to GeneCards Suite gene sharing:

(show top 50)    (show all 77)
idCompoundScoreTop Affiliating Genes
1eosin439.9GFAP, S100B
2s 100439.9S100B, GFAP
32,3-cyclic nucleotide439.8GFAP, S100B
4reticulin439.8S100B, GFAP
5propentofylline439.7GFAP, CHAT
6edss439.6S100B, APOE
7scopolamine43 28 24 1212.6CHRM1, CHAT
8pirenzepine43 28 1211.5CHRM1, CHAT
9homovanillic acid43 2410.4GFAP, CHAT
10quinolinic acid43 2410.4NTF4, CHAT, GFAP
11bromodeoxyuridine439.3NUDT6, GFAP, S100B
12benzodiazepine439.3CHAT, GFAP
13formaldehyde43 2410.2S100B, CHAT, GFAP
145-hydroxytryptamine439.2CHAT, CHRM1, GFAP
15l-amino acid439.1S100B, CHAT
16adenylate439.1S100B, NTF4, CHRM1, GFAP
17streptozotocin439.0APOE, GFAP, NUDT6
18donepezil43 49 24 1212.0CHAT, CHRM1, APOE
19olanzapine43 49 28 24 1213.0CHAT, CHRM1, APOE
20methionine438.9NUDT6, GFAP, S100B
21cocaine43 129.9GFAP, CHRM1, CHAT, S100B
22potassium43 24 1210.8GFAP, CHRM1, CHAT, S100B
23nicotine43 28 49 1211.8CHAT, CHRM1, APOE
24dbc-amp438.8NUDT6, GFAP, CHAT, S100B
25cyclic amp43 249.8GFAP, CHRM1, CHAT, S100B
26lactate438.8S100B, CHAT, GFAP, NUDT6
27phosphatidylinositol438.7NTF4, CHAT, CHRM1, NUDT6
28ethanol43 49 24 1211.6GFAP, CHRM1, CHAT, NTF4, S100B
29gaba438.5GFAP, CHRM1, CHAT, FABP7, S100B
30nitric oxide43 24 1210.5NUDT6, CHRM1, CHAT, S100B
31paraffin438.5GFAP, APOE, CHAT, S100B
32forskolin43 49 1210.5NUDT6, GFAP, CHAT, NTF4, S100B
33aspartate438.4S100B, CHAT, APOE, GFAP
34vegf438.4S100B, APOE, GFAP, NUDT6
35kainate43 289.4NUDT6, GFAP, APOE, CHAT
36atp43 289.3NUDT6, GFAP, CHRM1, CHAT, S100B
37serine438.1NUDT6, GFAP, APOE, NTF4, S100B
38estrogen438.1S100B, CHAT, APOE, GFAP
39retinoic acid43 249.1NUDT6, GFAP, CHAT, FABP7, NTF4, S100B
40nmda43 289.1NTF4, CHAT, APOE, GFAP, NUDT6
41choline43 24 1210.0NUDT6, GFAP, CHRM1, CHAT, NTF4, S100B
42tyrosine438.0NUDT6, GFAP, CHRM1, CHAT, NTF4, S100B
43testosterone43 59 24 1211.0NUDT6, GFAP, APOE, CHAT, S100B
44calcium43 49 24 1211.0NUDT6, GFAP, CHRM1, CHAT, NTF4, S100B
45arginine437.8NUDT6, GFAP, APOE, CHRM1, NTF4, S100B
46alanine437.7GFAP, APOE, CHRM1, CHAT, NTF4, S100B
47lipid437.7GFAP, APOE, CHRM1, CHAT, FABP7, S100B
48dopamine43 28 24 1210.6NUDT6, GFAP, APOE, CHRM1, CHAT, S100B
49acetylcholine43 49 28 24 1211.2S100B, NUDT6, GFAP, APOE, CHRM1, CHAT
50glutamate436.9NUDT6, GFAP, APOE, CHRM1, CHAT, FABP7

GO Terms for genes affiliated with Head Injury

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Cellular components related to Head Injury according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:00430258.2S100B, FABP7, CHAT, APOE

Biological processes related to Head Injury according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1long-term synaptic potentiationGO:00602919.5S100B, GFAP
2regulation of neuronal synaptic plasticityGO:00481689.1S100B, APOE
3neuromuscular synaptic transmissionGO:00072749.1CHAT, CHRM1

Molecular functions related to Head Injury according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1tau protein bindingGO:00481569.2S100B, APOE

Products for genes affiliated with Head Injury

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Sources for Head Injury

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet