Aliases & Classifications for Headache

Summaries for Headache

MedlinePlus : 41 almost everyone has had a headache. headache is the most common form of pain. it's a major reason people miss days at work or school or visit the doctor. the most common type of headache is a tension headache. tension headaches are due to tight muscles in your shoulders, neck, scalp and jaw. they are often related to stress, depression or anxiety. you are more likely to get tension headaches if you work too much, don't get enough sleep, miss meals, or use alcohol. other common types of headaches include migraines, cluster headaches, and sinus headaches. most people can feel much better by making lifestyle changes, learning ways to relax and taking pain relievers. not all headaches require a doctor's attention. but sometimes headaches warn of a more serious disorder. let your health care provider know if you have sudden, severe headaches. get medical help right away if you have a headache after a blow to your head, or if you have a headache along with a stiff neck, fever, confusion, loss of consciousness, or pain in the eye or ear. nih: national institute of neurological disorders and stroke

MalaCards based summary : Headache is related to cushing's syndrome and typhoid fever. An important gene associated with Headache is NPC1 (NPC Intracellular Cholesterol Transporter 1), and among its related pathways/superpathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Neuroscience. The drugs Dopamine and Nitric Oxide have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and eye, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and behavior/neurological

NINDS : 51 Headache is our most common form of pain and a major reason cited for days missed at work or school as well as visits to the doctor.  published by the International Headache Society, is used to classify more than 150 types of primary and secondary headache disorders. Primary headaches occur independently and are not caused by another medical condition.  Migraine, cluster, and tension-type headache are the more familiar types of primary headache.

Wikipedia : 71 Headache is the symptom of pain anywhere in the region of the head or neck. It occurs in migraines (... more...

Related Diseases for Headache

Diseases related to Headache via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 659)
id Related Disease Score Top Affiliating Genes
1 cushing's syndrome 30.7 CCK PTGS2
2 typhoid fever 30.7 ABCB1 CACNA1A CCK TAC1
3 dyspepsia 28.8 CCK NPY TAC1
4 cluster headache 12.3
5 hypnic headache 12.3
6 sunct headache 12.2
7 new daily-persistent headache 12.2
8 thunderclap headache 12.1
9 exertional headache 12.0
10 cough headache 12.0
11 handl syndrome 11.5
12 hemicrania continua 11.5
13 paroxysmal hemicrania 11.2
14 lyme disease 11.0
15 familial hemiplegic migraine 11.0
16 temporal arteritis 11.0
17 traumatic brain injury 11.0
18 meningitis 11.0
19 hydrocephalus 11.0
20 influenza 10.9
21 head injury 10.9
22 intracranial aneurysm 10.9
23 syringomyelia 10.9
24 encephalitis 10.9
25 aneurysm 10.9
26 brain injury 10.8
27 chiari malformation 10.8
28 cerebral aneurysms 10.8
29 cyclic vomiting syndrome 10.8
30 pituitary tumors 10.8
31 arteriovenous malformation 10.8
32 cadasil 10.8
33 episodic ataxia 10.8
34 pheochromocytoma 10.8
35 glioblastoma 10.8
36 chronic fatigue syndrome 10.8
37 refractive error 10.8
38 fibromuscular dysplasia 10.8
39 antiphospholipid syndrome 10.8
40 chronic pain 10.8
41 intracranial hypertension 10.8
42 reversible cerebral vasoconstriction syndrome 10.8
43 sinusitis 10.8
44 migraine with aura 10.8
45 occipital neuralgia 10.8
46 papilledema 10.8
47 bruxism 10.8
48 whiplash 10.8
49 arachnoid cysts 10.7
50 sleep apnea 10.7

Graphical network of the top 20 diseases related to Headache:



Diseases related to Headache

Symptoms & Phenotypes for Headache

GenomeRNAi Phenotypes related to Headache according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-10 9.58 CYP1A2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.58 HCRTR2
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.58 CYP1A2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 9.58 ABCB1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.58 CYP1A2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-154 9.58 ABCB1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.58 ABCB1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.58 SCN1A
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.58 ABCB1 CYP1A2 HCRTR2 SCN1A
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.58 SCN1A
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.58 CYP1A2
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.58 HCRTR2
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.58 SCN1A
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-62 9.58 SCN1A
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.58 ABCB1

MGI Mouse Phenotypes related to Headache:

44 (show all 11)
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.34 PTGS2 SCN1A NPC1 TAC1 TNF NPY
2 cardiovascular system MP:0005385 10.22 PTGS2 SCN1A NPC1 TAC1 TNF HLA-DQB1
3 homeostasis/metabolism MP:0005376 10.21 TNF PTGS2 IDO1 NPC1 NPY CACNA1A
4 endocrine/exocrine gland MP:0005379 10.11 TNF PTGS2 NPC1 CACNA1A HLA-DQB1 CCK
5 nervous system MP:0003631 10.1 PTGS2 SCN1A NPC1 TNF NPY HCRTR2
6 muscle MP:0005369 9.97 PTGS2 IDO1 TNF HCRTR2 CACNA1A HLA-DQB1
7 liver/biliary system MP:0005370 9.95 NPY TNF PTGS2 NPC1 HLA-DQB1 CYP1A2
8 normal MP:0002873 9.86 NPY PTGS2 SCN1A TAC1 CACNA1A HLA-DQB1
9 renal/urinary system MP:0005367 9.63 NPY PTGS2 IDO1 TAC1 HLA-DQB1 EDNRA
10 reproductive system MP:0005389 9.56 TNF PTGS2 IDO1 SCN1A NPC1 CACNA1A
11 respiratory system MP:0005388 9.23 PTGS2 NPC1 TNF CACNA1A HLA-DQB1 CYP1A2

Drugs & Therapeutics for Headache

Drugs for Headache (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 815)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
2
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1 10102-43-9 145068
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
4
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-78-2 2244
5
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 50-28-2 5757 53477783
6
Midazolam Approved, Illicit Phase 4,Phase 2 59467-70-8 4192
7
Iron Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 7439-89-6 23925
8
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
9
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1 103-90-2 1983
10
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
11
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1 15687-27-1 3672
12
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 99-66-1 3121
13
Nitroglycerin Approved, Investigational Phase 4,Phase 3,Phase 1 55-63-0 4510
14
Galantamine Approved Phase 4,Phase 2 357-70-0 9651 908828, 9651
15
Acetylcholine Approved Phase 4,Phase 2,Phase 3,Phase 1 51-84-3 187
16
Succinylcholine Approved Phase 4 306-40-1 5314
17
Metoclopramide Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 364-62-5 4168
18
Octreotide Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 83150-76-9 383414 6400441
19
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 75614-87-8, 51-45-6 774
20
Propranolol Approved, Investigational Phase 4,Phase 3,Phase 2 525-66-6 4946
21
Ticlopidine Approved Phase 4 55142-85-3 5472
22
Sumatriptan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 103628-46-2 5358
23
Topiramate Approved Phase 4,Phase 3,Phase 2,Phase 1 97240-79-4 5284627
24
Adenosine Approved, Investigational Phase 4,Phase 3,Phase 1 58-61-7 60961
25
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2 76631-46-4, 113775-47-6 68602 5311068 56032
26
Ephedrine Approved Phase 4,Phase 3,Phase 1 299-42-3 9294
27
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22204-53-1 1302 156391
28
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 137-58-6 3676
29
Diphenhydramine Approved Phase 4,Phase 2,Phase 3,Early Phase 1 58-73-1, 147-24-0 3100
30
Zonisamide Approved, Investigational Phase 4,Phase 3,Phase 2 68291-97-4 5734
31
Ondansetron Approved Phase 4,Phase 3 99614-02-5 4595
32
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
33
Acetazolamide Approved, Vet_approved Phase 4,Phase 2,Phase 3 59-66-5 1986
34
Amitriptyline Approved Phase 4,Phase 3,Phase 2,Phase 1 50-48-6 2160
35
Ketamine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 6740-88-1 3821
36
Ketorolac Approved Phase 4,Phase 2,Phase 3,Phase 1 74103-06-3, 66635-83-4 3826
37
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 26787-78-0 33613 2171
38
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 2078-54-8 4943
39
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
40
Acitretin Approved Phase 4 55079-83-9 6437841 5284513
41
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
42
Milnacipran Approved Phase 4 92623-85-3 65833
43
Perphenazine Approved Phase 4,Phase 3,Phase 2,Phase 1 58-39-9 4748
44
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
45
Almotriptan Approved, Investigational Phase 4,Phase 3 154323-57-6, 181183-52-8 123606
46
Aprepitant Approved, Investigational Phase 4,Phase 1,Phase 2 170729-80-3 151165 6918365
47
Pentazocine Approved, Vet_approved Phase 4 359-83-1 441278
48
Promethazine Approved Phase 4,Phase 2,Phase 3,Early Phase 1 60-87-7 4927
49
Pseudoephedrine Approved Phase 4,Phase 3,Phase 1 90-82-4 7028
50
Dihydroergotamine Approved Phase 4,Phase 3,Phase 1 6190-39-2, 511-12-6 10531

Interventional clinical trials:

(show top 50) (show all 1588)
id Name Status NCT ID Phase
1 Sumatriptan 4 mg Statdose in the Acute Treatment of Cluster Headache Unknown status NCT00399243 Phase 4
2 Randomized Placebo Controlled Trial With Etoricoxib That is Taken to Prevent the Yom Kippur Headache Unknown status NCT00752921 Phase 4
3 Galantamine in the Treatment of Post-Traumatic Headache Unknown status NCT00219869 Phase 4
4 Detoxification and Treatment of Subjects With Medication Overuse Headache Unknown status NCT00432549 Phase 4
5 Self-control Trial to Evaluate the Role of Aprepitant in the Prophylaxis of Post-lumbar-punture-headache (PLPH) Unknown status NCT02347878 Phase 4
6 Preventive Treatment of Episodic and Chronic Migraine Unknown status NCT01319825 Phase 4
7 Clopidogrel For the Prevention of New Onset Migraine Headache Following Transcatheter Closure of Atrial Septal Defects Unknown status NCT00799045 Phase 4
8 Effects on the Diagnostic Accuracy of Magnetic Imaging Angiographies of the Supra-Aortic Vessels by Three Different Magnetic Resonance Contrast Agents in Patients Unknown status NCT00132223 Phase 4
9 A Randomized Trial of Valproate Versus Ketorolac Versus Metoclopramide for Acute Migraine Unknown status NCT01267864 Phase 4
10 Prevention of Menstrual Migraines: Effects of Estrogen Add-back During the HFI in Patients Using Continuous Oral Contraceptives. Unknown status NCT01251263 Phase 4
11 American Migraine Prevention Study Unknown status NCT00363506 Phase 4
12 Gastrodin Prevents Cognitive Decline Related to Cardiopulmonary Bypass Unknown status NCT00297245 Phase 4
13 Strategy to Improve Adherence of Roflumilast Unknown status NCT02018432 Phase 4
14 Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty Unknown status NCT02094339 Phase 4
15 Comparing Carotid Stenting With Endarterectomy in Severe Asymptomatic Carotid Stenosis Unknown status NCT00772278 Phase 4
16 Evaluation of the Efficacy in Decreasing Iron Absorption in Patients With Congenital Dyserythropoietic Anemia Type I by Treatment With LOSEC Unknown status NCT01795794 Phase 4
17 Low-Dose (17.5 mg/Day) Acitretin: Comparable Efficacy Without the Side Effects? Unknown status NCT01228409 Phase 4
18 Occipital Transcutaneous Stimulation in Chronic Migraine Unknown status NCT02307071 Phase 4
19 Study of the Safety and Efficacy of Botox in Bruxism Unknown status NCT00908050 Phase 4
20 Middle Meatal Bacteriology During Acute Respiratory Infection in Children Unknown status NCT00545961 Phase 4
21 Effect of Subanesthetic Dose of Ketamine Combined With Propofol on Cognitive Function in Depressive Patients Undergoing Electroconvulsive Therapy Unknown status NCT02305394 Phase 4
22 Dexmedetomidine on Prevention of Side Effects of Hemabate Unknown status NCT02220361 Phase 4
23 Effect of COX-2 Selective Inhibitors on Postoperative Insulin Resistance After Gastrointestinal Laparoscopic Surgery Unknown status NCT01930318 Phase 4
24 A Research Study to Examine Cutaneous Allodynia and Cluster Headache Completed NCT00329836 Phase 4
25 Effect of Osteopathic Manipulative Treatment for Patients With Chronic Headache Completed NCT01332864 Phase 4
26 The CHECK Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine Completed NCT02657031 Phase 4
27 Metoclopramide Versus Ketorolac for Tension-type Headache Completed NCT01011673 Phase 4
28 Efficacy of Euminz® for Tension-Type Headache Completed NCT01770080 Phase 4
29 Trial of Etoricoxib (Arcoxia) Taken Prophylactically to Prevent Ramadan Headache Completed NCT01148303 Phase 4
30 Diclofenac Administered Before Skull Operations Reduces the Severity of Headache After the Intervention Completed NCT01907984 Phase 4
31 Placebo and Active Controlled, Double Dummy Study to Compare Efficacy of Aspirin and Ibuprofen in Treatment of Episodic Tension-type Headache Completed NCT01464983 Phase 4
32 A Study Comparing the Effectiveness and Safety of ULTRACET® (Tramadol HCl/Acetaminophen) Versus Placebo for the Treatment of Acute Pain From a Migraine Headache Completed NCT00297375 Phase 4
33 Zomig - Treatment of Acute Migraine Headache in Adolescents Completed NCT01211145 Phase 4
34 Comparing Naproxen to Sumatriptan for Emergency Headache Patients Completed NCT00449787 Phase 4
35 Cosyntropin Versus Epidural Blood Patch (EBP) for Treatment of Treatment of Post Dural Puncture Headache Completed NCT02394457 Phase 4
36 Comparative Study Between Hydrocortisone and Mannitol in Treatment of Postdural Puncture Headache Completed NCT02760862 Phase 4
37 Study on Migraine and Headache in Epileptic Patients Completed NCT00642564 Phase 4
38 Evaluation of the Effectiveness of Topiramate in Preventing the Transformation From Episodic Migraine to Chronic Daily Headache. Completed NCT00212810 Phase 4
39 An Open Trial of Duloxetine on Comorbid Major Depression and Chronic Headache Completed NCT00531895 Phase 4
40 Effectiveness And Safety Of Frovatriptan For The Management (Acute Treatment) Of Menstrual Migraine Completed NCT00904098 Phase 4
41 Oral Dexamethasone for Treatment of Migraine Completed NCT00216736 Phase 4
42 Haldol/Diphenhydramine Versus Metoclopramide/Diphenhydramine for Treatment of Acute Headache in the Emergency Department: A Randomized Controlled Trial Completed NCT02098499 Phase 4
43 A Study of the Effectiveness and Safety of Almotriptan Versus Placebo in the Treatment of Migraine Headache Completed NCT00210509 Phase 4
44 Intravenous Dexketoprofen and Paracetamol in the Treatment of Headache Caused by Acute Migraine Attack Completed NCT01730326 Phase 4
45 Effect of Vitamin D Supplementation on Muscular Strength, Musculoskeletal Pain and Headache Completed NCT01263288 Phase 4
46 Efficacy and Safety of Sinutab on Subjects in the Setting of a Common Cold Completed NCT00378144 Phase 4
47 The Effects of Expectation and Knowledge on Rizatriptan and Placebo Treatment of Acute Migraine Headache Completed NCT00719134 Phase 4
48 Rizatriptan in Acute Treatment of Migraine in Patients With Unilateral Trigeminal-autonomic Symptoms. Completed NCT00753311 Phase 4
49 Cupping and Serkangabin Versus Conventional Migraine Treatment Completed NCT01476930 Phase 4
50 Comparison of Oral Paracetamol and Zolmitriptan Efficacy in the Treatment of Acute Migraine in Emergency Department Completed NCT03145467 Phase 4

Search NIH Clinical Center for Headache

Genetic Tests for Headache

Genetic tests related to Headache:

id Genetic test Affiliating Genes
1 Headache 29

Anatomical Context for Headache

MalaCards organs/tissues related to Headache:

39
Brain, Pituitary, Eye, Testes, Hypothalamus, Heart, Pineal

Publications for Headache

Articles related to Headache:

(show top 50) (show all 2293)
id Title Authors Year
1
Improved surgical procedure using intraoperative navigation for the implantation of the SPG microstimulator in patients with chronic cluster headache. ( 28083804 )
2017
2
"Thunderclap" headache in a patient with depression: Answer. ( 28074778 )
2017
3
Identifying a gene expression signature of cluster headache in blood. ( 28074859 )
2017
4
Chronic paroxysmal headache secondary to an orbital metastatic leiomyosarcoma: A case report. ( 28058942 )
2017
5
Treatment of intractable chronic cluster headache by occipital nerve stimulation: a cohort of 51 patients. ( 27995704 )
2017
6
"Thunderclap" headache in a patient with depression: Question. ( 28074779 )
2017
7
Clinical characteristics of headache or facial pain prior to the development of acute herpes zoster of the head. ( 27978460 )
2017
8
Headache, Chiari malformation type 1 and treatment options. ( 28082322 )
2017
9
The International Headache Society: The history of its founding. ( 27215543 )
2016
10
Effectiveness of a Treatment Involving Soft Tissue Techniques and/or Neural Mobilization Techniques in the Management of the Tension-Type Headache: A Randomized Controlled Trial. ( 27623523 )
2016
11
Reversible Cerebral Vasoconstriction Syndrome Without Typical Thunderclap Headache. ( 27016378 )
2016
12
Cardiovascular Risk Factors in Cluster Headache. ( 28034970 )
2016
13
Psychedelic and nonpsychedelic LSD and psilocybin for cluster headache. ( 26883890 )
2016
14
Cluster headache in Greece: an observational clinical and demographic study of 302 patients. ( 27670427 )
2016
15
Atypically located cluster headache. ( 27813036 )
2016
16
Prevention of stress- or nitric oxide donor-induced medication overuse headache by a calcitonin gene-related peptide antibody in rodents. ( 27206958 )
2016
17
Brain pathology case of the month August 2016 - case 2 A 71 year old man presenting with headache, blurry vision and alexia without agraphia. ( 27647576 )
2016
18
Age of onset of episodic and chronic cluster headache - a review of a large case series from a single headache centre. ( 27102121 )
2016
19
Reversible cerebral vasoconstriction syndrome manifesting as focal seizures without a thunderclap headache: A pediatric case report. ( 27165442 )
2016
20
Hypertrophic Pachymeningitis as a Potential Cause of Headache Associated with Temporal Arteritis. ( 26935376 )
2016
21
Stress and Primary Headache: Review of the Research and Clinical Management. ( 27215628 )
2016
22
Oxygen therapy for cluster headache. A mask comparison trial. A single-blinded, placebo-controlled, crossover study. ( 27013239 )
2016
23
Migraine-like headache caused by rheumatic heart disease: The second case of 'Mahler's migraine'? ( 27503661 )
2016
24
Medication-overuse headache: risk factors, pathophysiology and management. ( 27615418 )
2016
25
Coexistence of contralateral cluster headache and probable paroxysmal hemicrania: a case report. ( 27047722 )
2016
26
Personality traits in patients with cluster headache: a comparison with migraine patients. ( 26975362 )
2016
27
Dizziness and Orthostatic Intolerance In Pediatric Headache Patients. ( 27017026 )
2016
28
Erratum to: Efficacy of epidural blood patch with fibrin glue additive in refractory headache due to intracranial hypotension: preliminary report. ( 27429870 )
2016
29
Bout-associated intrinsic functional network changes in cluster headache: A longitudinal resting-state functional MRI study. ( 27605571 )
2016
30
Cerebral arteriopathy with subcortical infarcts and leukoencephalopathy in acromegalic patient with severe headache. ( 28002537 )
2016
31
A Practical Approach to Autonomic Dysfunction in Patients with Headache. ( 27021770 )
2016
32
Nummular Headache Associated With Linear Scleroderma. ( 27477768 )
2016
33
Early pain relief from orthostatic headache and hearing changes in spontaneous intracranial hypotension after epidural blood patch. ( 26908033 )
2016
34
Vascular Emergencies and Shared Decision Making in Patients with Thunderclap Headache. ( 27311639 )
2016
35
Treatment of Cluster Headache: The American Headache Society Evidence-Based Guidelines. ( 27432623 )
2016
36
Relief of epilepsy and headache and quality of life after microsurgical treatment of unruptured brain AVM-audit of a single-center series and comprehensive review of the literature. ( 27209571 )
2016
37
Symptomatic trigeminal neuralgia and nocturnal thunderclap headache resulting from a carotid paraganglioma. ( 27226004 )
2016
38
Effective Botulinum Toxin Injection Guide for Treatment of Temporal Headache. ( 27618099 )
2016
39
Management of headache and associated factors among undergraduate medicine and health science students of University of Gondar, North West Ethiopia. ( 27216280 )
2016
40
Photophobia in primary headaches, in essential blepharospasm and in major depression. ( 27580344 )
2016
41
Thunderclap Headache Secondary to Pneumocephalus Following Epidural Anesthesia. ( 27366299 )
2016
42
Headache with markedly hypodense cerebral venous sinuses. ( 27625436 )
2016
43
Field testing of ICHD-3 beta criteria of periictal headaches in patients with focal epilepsy - a prospective diary study. ( 27940879 )
2016
44
New Daily Persistent Headache Caused by a Multinodular Goiter and Headaches Associated With Thyroid Disease. ( 28025831 )
2016
45
Update on New Daily Persistent Headache. ( 27080086 )
2016
46
Raeder's Paratrigeminal Syndrome: Headache and Horner's Lacking Anhidrosis. ( 26902244 )
2016
47
Use of Nonsteroidal Anti-Inflammatory Drugs for Symptomatic Treatment of Episodic Headache. ( 27207273 )
2016
48
The development and validation of the Cluster Headache Quality of life scale (CHQ). ( 27596922 )
2016
49
Migraine-Like Headache as Presentation Symptom in Susac Syndrome. ( 27781269 )
2016
50
Long Lasting Impairment of Taste and Smell as Side Effect of Lithium Carbonate in a Cluster Headache Patient. ( 27317012 )
2016

Variations for Headache

ClinVar genetic disease variations for Headache:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 NPC1 NM_000271.4(NPC1): c.3019C> G (p.Pro1007Ala) single nucleotide variant Pathogenic rs80358257 GRCh37 Chromosome 18, 21118528: 21118528
2 NPC1 NM_000271.4(NPC1): c.1421C> T (p.Pro474Leu) single nucleotide variant Pathogenic rs372445155 GRCh38 Chromosome 18, 23554890: 23554890

Expression for Headache

Search GEO for disease gene expression data for Headache.

Pathways for Headache

GO Terms for Headache

Cellular components related to Headache according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.46 CALCA CCK SCN1A TAC1
2 neuronal cell body GO:0043025 9.02 CACNA1A CALCA CCK SCN1A TAC1
3 axon initial segment GO:0043194 8.96 CCK SCN1A

Biological processes related to Headache according to GeneCards Suite gene sharing:

(show all 17)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.86 CCK IDO1 PTGS2 TNF
2 response to drug GO:0042493 9.85 ABCB1 CYP1A2 NPC1 PTGS2
3 chemical synaptic transmission GO:0007268 9.8 CACNA1A HCRTR2 NPY TAC1
4 inflammatory response GO:0006954 9.8 CALCA IDO1 PTGS2 TAC1 TNF
5 response to lipopolysaccharide GO:0032496 9.78 CYP1A2 IDO1 PTGS2 TAC1
6 response to organic substance GO:0010033 9.7 CYP1A2 PTGS2 TNF
7 positive regulation of cytosolic calcium ion concentration GO:0007204 9.62 CACNA1A CALCA EDNRA TAC1
8 positive regulation of NF-kappaB import into nucleus GO:0042346 9.57 PTGS2 TNF
9 positive regulation of ossification GO:0045778 9.54 CALCA TAC1
10 feeding behavior GO:0007631 9.54 CALCA HCRTR2 NPY
11 cellular response to steroid hormone stimulus GO:0071383 9.51 ATP1A2 NPC1
12 negative regulation of smooth muscle contraction GO:0045986 9.46 CALCA PTGS2
13 neuropeptide signaling pathway GO:0007218 9.46 CALCA HCRTR2 NPY TAC1
14 positive regulation of fever generation GO:0031622 9.43 PTGS2 TNF
15 adult walking behavior GO:0007628 9.43 CACNA1A NPC1 SCN1A
16 response to pain GO:0048265 9.13 CACNA1A CALCA TAC1
17 regulation of blood pressure GO:0008217 9.1 ATP1A2 CALCA EDNRA NPY PTGS2 TAC1

Molecular functions related to Headache according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 9.13 CYP1A2 IDO1 PTGS2
2 hormone activity GO:0005179 8.8 CALCA CCK NPY

Sources for Headache

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....