MCID: HDC001
MIFTS: 58

Headache malady

Neuronal diseases category
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Summaries for Headache

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MedlinePlus:33 Almost everyone has had a headache. headache is the most common form of pain. it's a major reason people miss days at work or school or visit the doctor. the most common type of headache is a tension headache. tension headaches are due to tight muscles in your shoulders, neck, scalp and jaw. they are often related to stress, depression or anxiety. you are more likely to get tension headaches if you work too much, don't get enough sleep, miss meals, or use alcohol. other common types of headaches include migraines, cluster headaches, and sinus headaches. most people can feel much better by making lifestyle changes, learning ways to relax and taking pain relievers. not all headaches require a doctor's attention. but sometimes headaches warn of a more serious disorder. let your health care provider know if you have sudden, severe headaches. get medical help right away if you have a headache after a blow to your head, or if you have a headache along with a stiff neck, fever, confusion, loss of consciousness, or pain in the eye or ear. nih: national institute of neurological disorders and stroke

MalaCards based summary: Headache is related to cluster headache and familial hemiplegic migraine. An important gene associated with Headache is EDNRA (endothelin receptor type A), and among its related pathways are Endothelin and Adenylate cyclase activating neuropeptides. The compounds n(g)-nitro-l-arginine methyl ester and mdl 100907 have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and pituitary, and related mouse phenotypes are cardiovascular system and endocrine/exocrine gland.

NINDS:43 There are four types of headache:

Wikipedia:65 A headache or cephalalgia is pain anywhere in the region of the head or neck. It can be a symptom of a... more...

Aliases & Classifications for Headache

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Related Diseases for Headache

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Diseases related to Headache via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 584)
idRelated DiseaseScoreTop Affiliating Genes
1cluster headache31.5CALCA, CACNA1A, HCRTR2, HTR3A, VIP
2familial hemiplegic migraine30.9CACNA1A
3migraine30.5EDNRA, CALCA, CACNA1A, HTR2A, HTR3A, HTR1B
4fibromyalgia30.5HTR2A, HTR3A
5generalized anxiety disorder30.4HTR3A, HTR2A
6rhinitis30.3VIP, EDNRA
7pheochromocytoma30.2EDNRA, HCRTR2, CALCA, VIP
8serotonin syndrome30.2HTR3A, HTR2A
9substance abuse30.2ADH4
10anxiety disorder30.1HTR2A, HTR3A
11impotence30.1VIP, EDNRA
12constipation30.1VIP, HTR3A
13cerebrovascular disease30.1VIP, HTR2A, EDNRA, HTR3A
14bipolar disorder30.0HTR3A, HTR2A
15congenital heart disease30.0VIP, HTR2A, HP
16eating disorder30.0HTR3A, HTR2A
17panic disorder29.9HTR2A, HTR3A
18anorexia nervosa29.8HTR3A, HTR2A
19mood disorder29.6HTR2A, HTR1B, HTR3A
20carcinoid syndrome29.6CALCA, HTR3A, HTR2A, VIP
21arthritis29.6HP, CALCA, VIP
22parkinson's disease29.5HTR2A, HTR1B, HTR3A
23thunderclap headache10.8
24hypnic headache10.7
25new daily-persistent headache10.7
26intracranial hypotension10.6
27exertional headache10.6
28cerebritis10.6
29cough headache10.6
30paroxysmal hemicrania10.5
31hypertension10.5
32hemicrania continua10.5
33migraine without aura10.5
34vipoma10.5VIP
35intracranial hypertension10.5
36cervicitis10.4
37carotid artery dissection10.4
38meningitis10.4
39migraine with aura10.4
40aneurysm10.4
41wdha syndrome10.4VIP, CALCA
42sinusitis10.4
43occipital neuralgia10.4
44pancreatic islet cell tumors10.3VIP, CALCA
45somatostatinoma10.3VIP, CALCA
46papilledema10.3
47patent foramen ovale10.3
48whiplash10.3
49sunct headache10.3
50blindness10.3

Graphical network of the top 20 diseases related to Headache:



Diseases related to headache

Symptoms for Headache

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Drugs & Therapeutics for Headache

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Drug clinical trials:

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Genetic Tests for Headache

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Anatomical Context for Headache

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MalaCards organs/tissues related to Headache:

32
Brain, Eye, Pituitary, Testes, Hypothalamus, Heart, Spinal cord, Pineal, Lung, Cortex, Cerebellum, Colon, Liver, Skin, Ovary, Endothelial, Temporal lobe, Thalamus, Amygdala, Dorsal root ganglion, Neutrophil

Animal Models for Headache or affiliated genes

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MGI Mouse Phenotypes related to Headache:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.5CALCA, HP, HTR1B, VIP, EDNRA
2MP:00053798.2EDNRA, VIP, HTR2A, HTR1B, HTR3A
3MP:00053698.0EDNRA, HCRTR2, HTR2A, HTR1B, HTR3A, CACNA1A
4MP:00036317.6EDNRA, HCRTR2, ADH7, HTR3A, CACNA1A, CALCA
5MP:00053767.6EDNRA, VIP, ADH7, HTR3A, HP, CACNA1A
6MP:00107687.5EDNRA, VIP, ADH7, HTR3A, HP, CACNA1A
7MP:00053866.9CALCA, HCRTR2, VIP, ADH7, HTR2A, HTR1B

Publications for Headache

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Articles related to Headache:

(show top 50)    (show all 1967)
idTitleAuthorsYear
1
Study of cluster headache: A hospital-based study. (25288839)
2014
2
Discussion: nonendoscopic deactivation of nerve triggers in migraine headache patients: surgical technique and outcomes. (25357036)
2014
3
Corticosteroids alter CGRP and melatonin release in cluster headache episodes. (24958681)
2014
4
Peripheral Nerve Field Stimulation for Chronic Headache: 60 Cases and Long-Term Follow-Up. (24165152)
2013
5
Two-tiered approach to MRI for headache: a cost-effective way to use an expensive technology. (23789700)
2013
6
Effective surgical revascularization improves cerebral hemodynamics and resolves headache in pediatric Moyamoya disease. (23022638)
2013
7
Investigation of whole-brain white matter identifies altered water mobility in the pathogenesis of high-altitude headache. (23736642)
2013
8
Headache and vasculitis. (23338772)
2013
9
Monthly variation of United States pediatric headache emergency department visits. (24335850)
2013
10
Postcraniotomy headache. (23846599)
2013
11
Relationship between headache and mucosal mast cells in pediatric Helicobacter pylori-negative functional dyspepsia. (23291287)
2013
12
A case of cluster headache treated with rotigotine: clinical and neurophysiological correlates. (23709498)
2013
13
Impact of continuing or quitting smoking on episodic cluster headache: a pilot survey. (23742010)
2013
14
Thunderclap headache: diagnostic considerations and neuroimaging features. (23245274)
2013
15
Headache and comorbidity in children and adolescents. (24063537)
2013
16
Headache in school children: prevalence and risk factors. (24333367)
2013
17
Prediction of headache severity (density and functional impact) after traumatic brain injury: A longitudinal multicenter study. (23575819)
2013
18
Epidemiology and clinical characteristics of chronic daily headache in a clinic-based cohort of Iranian population. (24068481)
2013
19
Advice alone versus structured detoxification programmes for complicated medication overuse headache (MOH): a prospective, randomized, open-label trial. (23565591)
2013
20
Sedative dosing of propofol for treatment of migraine headache in the emergency department: a case series. (24381692)
2013
21
Stimulation of the sphenopalatine ganglion (SPG) for cluster headache treatment. Pathway CH-1: A randomized, sham-controlled study. (23314784)
2013
22
Occipital nerve stimulation for medically refractory hypnic headache. (22376140)
2012
23
Ischemic stroke presenting as thunderclap headache: report of two cases and review of the literature. (21865762)
2011
24
A patient with superficial siderosis, intraspinal cyst, low-pressure headache and low-lying cord. (22368982)
2011
25
Bruxism, temporomandibular dysfunction, tension-type headache, and migraine. (21762137)
2011
26
Levels of nitric oxide metabolites in cerebrospinal fluid in cluster headache. (20511209)
2010
27
Post-infectious new daily persistent headache may respond to intravenous methylprednisolone. (19936615)
2010
28
Cardiac cephalalgia presented with a thunderclap headache and an isolated exertional headache: report of 2 cases. (20714954)
2010
29
Oxygen treatment in acute cluster headache. (19272273)
2009
30
Genetic aspects of cluster headache. (19271945)
2009
31
Medical image. Severe headache when standing. Intracranial hypotension. (19319177)
2009
32
Cerebral non-Langerhans cell histiocytosis in a 17-year-old patient with a headache: case report. (19363626)
2009
33
Cluster headache during pregnancy: case report and literature review. (19125883)
2009
34
Prevalence of cluster headache in the Republic of Georgia: results of a population-based study and methodological considerations. (19250289)
2009
35
Cluster headache, hypothalamus, and orexin. (19272281)
2009
36
Resolution of diplopia with late treatment of post-dural puncture headache and intracranial hypotension. (18378978)
2008
37
Involvement of corticotrophin-releasing factor and orexin-A in chronic migraine and medication-overuse headache: findings from cerebrospinal fluid. (18479471)
2008
38
Elevation of CSF tumor necrosis factor alpha levels in new daily persistent headache and treatment refractory chronic migraine. (17635596)
2007
39
G protein beta3 polymorphism and triptan response in cluster headache. (17361120)
2007
40
Headache in a patient with Klinefelter's syndrome and hyperostosis frontalis interna. (18071629)
2007
41
The headache-inducing effect of cilostazol in human volunteers. (17059437)
2006
42
A genome-wide scan and HCRTR2 candidate gene analysis in a European cluster headache cohort. (16801656)
2006
43
Valdecoxib for treatment of a single, acute, moderate to severe migraine headache. (16178945)
2005
44
Systemic autonomic involvement in episodic cluster headache: a comparison between active and remission periods. (16362675)
2005
45
Differentiating paroxysmal hemicrania from cluster headache. (15773820)
2005
46
Impairment of trigeminal sensory pathways in cluster headache. (15377328)
2004
47
Sensory nerves in man and their role in primary headaches. (11595008)
2001
48
Antinuclear and anticardiolipin antibodies in primary headache syndromes]. (12799962)
1998
49
The insulin tolerance test and the ovine corticotrophin-releasing hormone test in episodic cluster headache. (1665104)
1991
50
A new etiology for visual impairment and chronic headache. The Tolosa-Hunt syndrome may be only one manifestation of venous vasculitis. (3698095)
1986

Variations for Headache

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Expression for genes affiliated with Headache

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Expression patterns in normal tissues for genes affiliated with Headache

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Pathways for genes affiliated with Headache

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Pathways related to Headache according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9EDNRA, CALCA
29.9HCRTR2, CALCA
3
Show member pathways
9.3EDNRA, HCRTR2, HTR2A
4
Show member pathways
9.3HTR1B, HTR2A
59.2CACNA1A, HTR2A, EDNRA
6
Show member pathways
phenylalanine utilization37
noradrenaline and adrenaline degradation37
phenylalanine degradation IV37
9.1ADH4, ADH7
7
Show member pathways
9.1ADH4, ADH7
89.0HTR2A, HTR1B, HTR3A
9
Show member pathways
8.5HTR3A, HTR2A, HTR1B, CACNA1A
10
Show member pathways
8.5CACNA1A, HTR3A, HTR1B, HTR2A
11
Show member pathways
8.4HTR1B, CALCA, HTR2A, HCRTR2, EDNRA
12
Show member pathways
8.1EDNRA, HCRTR2, CALCA, HTR1B, HTR2A, VIP

Compounds for genes affiliated with Headache

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Compounds related to Headache according to GeneCards/GeneDecks:

(show top 50)    (show all 152)
idCompoundScoreTop Affiliating Genes
1n(g)-nitro-l-arginine methyl ester449.9VIP, CALCA, EDNRA
2mdl 100907449.8HTR3A, HTR2A
3phosphoramidon44 1110.8EDNRA, VIP, CALCA
4mdl 72222449.8HTR3A, HTR2A
5alpha methyl 5 hydroxytryptamine449.8HTR2A, HTR3A
6ly 53857449.8HTR3A, HTR2A
7triptan449.7CALCA, HTR1B, HTR3A
8alpha-methylserotonin449.6HTR2A, HTR3A
9tetrodotoxin44 61 2811.6EDNRA, CALCA, VIP, HTR3A
10(tfmpp)449.4HTR2A, HTR3A, HTR1B
111-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane449.4HTR1B, HTR2A, HTR3A
12cyanopindolol44 2810.4HTR3A, HTR1B, HTR2A
13ru 2496928 4410.4HTR2A, HTR3A, HTR1B
142-methyl-5-ht44 2810.4HTR1B, HTR3A, HTR2A
15mcpp449.4HTR1B, HTR2A, HTR3A
165-carboxamidotryptamine449.4HTR3A, HTR1B, HTR2A
17ipsapirone44 2810.4HTR1B, HTR2A, HTR3A
18pindolol44 28 1111.4HTR1B, HTR2A, HTR3A
19dihydroergotamine44 28 1111.4HTR3A, HTR1B, HTR2A
20zotepine44 2810.4HTR3A, HTR2A, HTR1B
21methiothepin44 2810.4HTR3A, HTR1B, HTR2A
22ritanserin44 2810.4HTR3A, HTR1B, HTR2A
23metergoline44 2810.4HTR1B, HTR2A, HTR3A
24methysergide44 28 1111.4HTR1B, HTR2A, HTR3A
25tryptamine44 28 2411.4HTR3A, HTR1B, HTR2A
26nefazodone44 50 1111.4HTR3A, HTR1B, HTR2A
27fenfluramine44 28 1111.3HTR3A, HTR1B, HTR2A
28ergotamine28 44 1111.3HTR3A, HTR2A, HTR1B
29ketanserin44 2810.3HTR3A, HTR1B, HTR2A
30Serotonin249.3HTR2A, HTR3A, HTR1B
31venlafaxine44 50 24 1112.3HTR1B, HTR3A, HTR2A
32phenylbiguanide449.3HTR2A, HTR3A
33clomipramine44 50 1111.3HTR2A, HTR1B, HTR3A
34ondansetron50 44 24 1112.3HTR2A, HTR1B, HTR3A
35aripiprazole28 44 50 24 1113.3HTR1B, HTR3A, HTR2A
36ziprasidone28 50 44 1112.3HTR2A, HTR1B, HTR3A
37yohimbine44 2 28 1112.3HTR1B, HTR3A, HTR2A
38propranolol44 28 50 24 1113.2HTR3A, CALCA, HTR1B, VIP
39paroxetine44 50 28 1112.2HTR3A, HTR1B, HTR2A
40histamine44 28 2411.2HCRTR2, EDNRA, VIP, HTR3A, CALCA
41acth449.2HP, HCRTR2, CALCA, VIP
42quetiapine44 50 28 24 1113.1HTR3A, HTR1B, HTR2A
43adenylate449.0CALCA, HP, HTR3A, VIP, EDNRA
44bromocriptine44 28 1111.0HTR1B, VIP, HTR2A
45acetylcholine44 50 28 24 1112.8EDNRA, HCRTR2, VIP, HTR3A, CACNA1A, CALCA
46norepinephrine44 24 1110.8EDNRA, CALCA, HTR3A, HTR2A, VIP, HCRTR2
47sumatriptan44 28 61 50 24 1113.8HTR1B, HTR2A, CALCA, HTR3A, VIP
485-hydroxytryptamine448.8CALCA, HTR3A, HTR1B, HTR2A, VIP
49dopamine44 28 24 1111.5CALCA, EDNRA, VIP, HTR2A, HTR1B, HTR3A
50testosterone44 61 24 1111.4HTR1B, HP, EDNRA, VIP, CALCA

GO Terms for genes affiliated with Headache

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Cellular components related to Headache according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430258.4VIP, HTR2A, HTR3A, CACNA1A, CALCA
2integral component of plasma membraneGO:0058878.1EDNRA, HCRTR2, HTR2A, HTR1B, HTR3A
3plasma membraneGO:0058867.9EDNRA, HCRTR2, HTR2A, HTR1B, HTR3A, CACNA1A

Biological processes related to Headache according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling paGO:05148210.1EDNRA, CALCA
2artery smooth muscle contractionGO:01482410.0HTR2A, EDNRA
3activation of adenylate cyclase activityGO:00719010.0CALCA, EDNRA
4detection of temperature stimulus involved in sensory perception of painGO:05096510.0CALCA, HTR2A
5positive regulation of vasodilationGO:04590910.0VIP, CALCA
6serotonin receptor signaling pathwayGO:0072109.9HTR2A, HTR3A
7feeding behaviorGO:0076319.9CALCA, HCRTR2
8negative regulation of cAMP biosynthetic processGO:0308189.9EDNRA, HTR1B
9negative regulation of potassium ion transportGO:0432679.9VIP, HTR2A
10G-protein coupled receptor internalizationGO:0020319.8CALCA, HTR1B
11vasoconstrictionGO:0423109.8HTR1B, EDNRA
12positive regulation of cytosolic calcium ion concentrationGO:0072049.8EDNRA, CALCA, CACNA1A
13agingGO:0075689.7EDNRA, HTR2A, CALCA
14response to cocaineGO:0422209.7HTR1B, HTR3A
15regulation of dopamine secretionGO:0140599.7HTR1B, HTR2A
16activation of phospholipase C activityGO:0072029.7HTR2A, EDNRA
17negative regulation of synaptic transmission, glutamatergicGO:0519679.6HTR1B, HTR2A
18regulation of blood pressureGO:0082179.6CALCA, EDNRA
19regulation of behaviorGO:0507959.6HTR1B, HTR2A
20protein kinase C-activating G-protein coupled receptor signaling pathwayGO:0072059.6EDNRA, HTR1B
21ethanol oxidationGO:0060699.4ADH7, ADH4
22retinol metabolic processGO:0425729.3ADH4, ADH7
23response to ethanolGO:0454719.0ADH7, HTR3A, HTR1B
24retinoid metabolic processGO:0015239.0ADH7, ADH4
25synaptic transmissionGO:0072688.6HTR2A, HCRTR2, HTR1B, HTR3A, CACNA1A

Molecular functions related to Headache according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1ethanol bindingGO:0352769.2ADH7, ADH4
2serotonin bindingGO:0513789.1HTR2A, HTR1B, HTR3A
3alcohol dehydrogenase activity, zinc-dependentGO:0040249.1ADH4, ADH7
4retinol dehydrogenase activityGO:0047459.1ADH7, ADH4
5serotonin receptor activityGO:0049939.1HTR2A, HTR1B, HTR3A
6alcohol dehydrogenase (NAD) activityGO:0040229.0ADH4, ADH7
7retinol bindingGO:0198418.8ADH4, ADH7

Products for genes affiliated with Headache

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  • Antibodies
  • Proteins
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Sources for Headache

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet