MCID: HDC001
MIFTS: 58

Headache malady

Neuronal diseases category

Summaries for Headache

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Sources:
35MedlinePlus, 45NINDS, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Almost everyone has had a headache. headache is the most common form of pain. it's a major reason people miss days at work or school or visit the doctor. the most common type of headache is a tension headache. tension headaches are due to tight muscles in your shoulders, neck, scalp and jaw. they are often related to stress, depression or anxiety. you are more likely to get tension headaches if you work too much, don't get enough sleep, miss meals, or use alcohol. other common types of headaches include migraines, cluster headaches, and sinus headaches. most people can feel much better by making lifestyle changes, learning ways to relax and taking pain relievers. not all headaches require a doctor's attention. but sometimes headaches warn of a more serious disorder. let your health care provider know if you have sudden, severe headaches. get medical help right away if you have a headache after a blow to your head, or if you have a headache along with a stiff neck, fever, confusion, loss of consciousness, or pain in the eye or ear. nih: national institute of neurological disorders and stroke

MalaCards: Headache is related to cluster headache and migraine. An important gene associated with Headache is EDNRA (endothelin receptor type A), and among its related pathways are Endothelin and Adenylate cyclase activating neuropeptides. The compounds n(g)-nitro-l-arginine methyl ester and mdl 100907 have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and pituitary, and related mouse phenotypes are cardiovascular system and endocrine/exocrine gland.

NINDS:45 There are four types of headache:

Wikipedia:66 A headache or cephalalgia is pain anywhere in the region of the head or neck. It can be a symptom of a... more...

Aliases & Classifications for Headache

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Sources:
45NINDS, 35MedlinePlus, 26ICD10
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Related Diseases for Headache

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Headache via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 562)
idRelated DiseaseScoreTop Affiliating Genes
1cluster headache31.6HCRTR2, VIP, HTR3A, CACNA1A, CALCA
2migraine31.2CALCA, EDNRA, VIP, HTR2A, HTR1B, HTR3A
3familial hemiplegic migraine30.2CACNA1A
4fibromyalgia30.2HTR2A, HTR3A
5pheochromocytoma30.1EDNRA, HCRTR2, VIP, CALCA
6cerebrovascular disease30.1HTR3A, HTR2A, VIP, EDNRA
7generalized anxiety disorder30.1HTR2A, HTR3A
8rhinitis30.0EDNRA, VIP
9serotonin syndrome29.9HTR2A, HTR3A
10anxiety disorder29.9HTR2A, HTR3A
11coronary artery disease29.9HP, HTR3A, EDNRA
12anorexia nervosa29.9HTR3A, HTR2A
13congenital heart disease29.9VIP, HTR2A, HP
14substance abuse29.8ADH4
15impotence29.7EDNRA, VIP
16constipation29.7VIP, HTR3A
17bipolar disorder29.7HTR3A, HTR2A
18eating disorder29.7HTR2A, HTR3A
19panic disorder29.7HTR2A, HTR3A
20mood disorder29.6HTR2A, HTR1B, HTR3A
21carcinoid syndrome29.6CALCA, HTR3A, HTR2A, VIP
22arthritis29.6CALCA, HP, VIP
23parkinson's disease29.6HTR2A, HTR1B, HTR3A
24thunderclap headache10.8
25hypnic headache10.7
26new daily-persistent headache10.6
27intracranial hypotension10.6
28exertional headache10.6
29cough headache10.6
30cerebritis10.6
31paroxysmal hemicrania10.5
32hypertension10.5
33hemicrania continua10.5
34migraine without aura10.5
35intracranial hypertension10.4
36cervicitis10.4
37carotid artery dissection10.4
38meningitis10.4
39migraine with aura10.4
40aneurysm10.3
41papilledema10.3
42occipital neuralgia10.3
43sinusitis10.3
44whiplash10.3
45bruxism10.3
46patent foramen ovale10.3
47sunct headache10.3
48temporal arteritis10.3
49cerebrospinal fluid leak10.3
50blindness10.3

Graphical network of the top 20 diseases related to Headache:



Diseases related to headache

Symptoms for Headache

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Drugs & Therapeutics for Headache

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Headache

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Genetic Tests for Headache

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Anatomical Context for Headache

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Sources:
34MalaCards
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MalaCards organs/tissues related to Headache:

34
Brain, Eye, Pituitary, Testes, Hypothalamus, Heart, Spinal cord, Pineal, Lung, Cortex, Amygdala, Dorsal root ganglion, Thalamus, Temporal lobe, Endothelial, Cerebellum, Skin, Liver, Colon, Ovary

Animal Models for Headache or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Headache:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.5CALCA, HP, HTR1B, VIP, EDNRA
2MP:00053798.2EDNRA, VIP, HTR2A, HTR1B, HTR3A
3MP:00053698.0EDNRA, HCRTR2, HTR2A, HTR1B, HTR3A, CACNA1A
4MP:00036317.6EDNRA, HCRTR2, ADH7, HTR3A, CACNA1A, CALCA
5MP:00053767.6EDNRA, VIP, ADH7, HTR3A, HP, CACNA1A
6MP:00107687.5EDNRA, VIP, ADH7, HTR3A, HP, CACNA1A
7MP:00053866.9CALCA, HCRTR2, VIP, ADH7, HTR2A, HTR1B

Publications for Headache

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Sources:
53PubMed
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Articles related to Headache:

(show top 50)    (show all 1874)
idTitleAuthorsYear
1
Peripheral Nerve Field Stimulation for Chronic Headache: 60 Cases and Long-Term Follow-Up. (24165152)
2013
2
Two-tiered approach to MRI for headache: a cost-effective way to use an expensive technology. (23789700)
2013
3
Effective surgical revascularization improves cerebral hemodynamics and resolves headache in pediatric Moyamoya disease. (23022638)
2013
4
Investigation of whole-brain white matter identifies altered water mobility in the pathogenesis of high-altitude headache. (23736642)
2013
5
Headache and vasculitis. (23338772)
2013
6
Monthly variation of United States pediatric headache emergency department visits. (24335850)
2013
7
Postcraniotomy headache. (23846599)
2013
8
Relationship between headache and mucosal mast cells in pediatric Helicobacter pylori-negative functional dyspepsia. (23291287)
2013
9
A case of cluster headache treated with rotigotine: clinical and neurophysiological correlates. (23709498)
2013
10
Impact of continuing or quitting smoking on episodic cluster headache: a pilot survey. (23742010)
2013
11
Thunderclap headache: diagnostic considerations and neuroimaging features. (23245274)
2013
12
Headache and comorbidity in children and adolescents. (24063537)
2013
13
Headache in school children: prevalence and risk factors. (24333367)
2013
14
Prediction of headache severity (density and functional impact) after traumatic brain injury: A longitudinal multicenter study. (23575819)
2013
15
Epidemiology and clinical characteristics of chronic daily headache in a clinic-based cohort of Iranian population. (24068481)
2013
16
Advice alone versus structured detoxification programmes for complicated medication overuse headache (MOH): a prospective, randomized, open-label trial. (23565591)
2013
17
Sedative dosing of propofol for treatment of migraine headache in the emergency department: a case series. (24381692)
2013
18
Stimulation of the sphenopalatine ganglion (SPG) for cluster headache treatment. Pathway CH-1: A randomized, sham-controlled study. (23314784)
2013
19
Occipital nerve stimulation for medically refractory hypnic headache. (22376140)
2012
20
Ischemic stroke presenting as thunderclap headache: report of two cases and review of the literature. (21865762)
2011
21
Neuromodulation of the posterolateral hypothalamus for the treatment of chronic refractory cluster headache: Experience in five patients with a modified anatomical target. (22116943)
2011
22
A patient with superficial siderosis, intraspinal cyst, low-pressure headache and low-lying cord. (22368982)
2011
23
Bruxism, temporomandibular dysfunction, tension-type headache, and migraine. (21762137)
2011
24
Levels of nitric oxide metabolites in cerebrospinal fluid in cluster headache. (20511209)
2010
25
Post-infectious new daily persistent headache may respond to intravenous methylprednisolone. (19936615)
2010
26
Cardiac cephalalgia presented with a thunderclap headache and an isolated exertional headache: report of 2 cases. (20714954)
2010
27
Oxygen treatment in acute cluster headache. (19272273)
2009
28
Genetic aspects of cluster headache. (19271945)
2009
29
Medical image. Severe headache when standing. Intracranial hypotension. (19319177)
2009
30
Cerebral non-Langerhans cell histiocytosis in a 17-year-old patient with a headache: case report. (19363626)
2009
31
Cluster headache during pregnancy: case report and literature review. (19125883)
2009
32
Prevalence of cluster headache in the Republic of Georgia: results of a population-based study and methodological considerations. (19250289)
2009
33
Cluster headache, hypothalamus, and orexin. (19272281)
2009
34
Resolution of diplopia with late treatment of post-dural puncture headache and intracranial hypotension. (18378978)
2008
35
Involvement of corticotrophin-releasing factor and orexin-A in chronic migraine and medication-overuse headache: findings from cerebrospinal fluid. (18479471)
2008
36
Elevation of CSF tumor necrosis factor alpha levels in new daily persistent headache and treatment refractory chronic migraine. (17635596)
2007
37
G protein beta3 polymorphism and triptan response in cluster headache. (17361120)
2007
38
Headache in a patient with Klinefelter's syndrome and hyperostosis frontalis interna. (18071629)
2007
39
The headache-inducing effect of cilostazol in human volunteers. (17059437)
2006
40
A genome-wide scan and HCRTR2 candidate gene analysis in a European cluster headache cohort. (16801656)
2006
41
Using ice cream headache to help physicians experience the pain of and empathize with cluster headache patients. (16288968)
2006
42
Valdecoxib for treatment of a single, acute, moderate to severe migraine headache. (16178945)
2005
43
Systemic autonomic involvement in episodic cluster headache: a comparison between active and remission periods. (16362675)
2005
44
Differentiating paroxysmal hemicrania from cluster headache. (15773820)
2005
45
Decreasing incidence of cluster headache: a population-based study in Olmsted County, Minnesota. (15836596)
2005
46
Impairment of trigeminal sensory pathways in cluster headache. (15377328)
2004
47
Sensory nerves in man and their role in primary headaches. (11595008)
2001
48
Antinuclear and anticardiolipin antibodies in primary headache syndromes]. (12799962)
1998
49
The insulin tolerance test and the ovine corticotrophin-releasing hormone test in episodic cluster headache. (1665104)
1991
50
A new etiology for visual impairment and chronic headache. The Tolosa-Hunt syndrome may be only one manifestation of venous vasculitis. (3698095)
1986

Variations for Headache

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Expression for genes affiliated with Headache

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Headache

Search GEO for disease gene expression data for Headache.

Pathways for genes affiliated with Headache

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Sources:
51PathCards, 39NCBI BioSystems Database, 13EMD Millipore, 56Reactome, 31KEGG, 52PharmGKB, 54QIAGEN
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Pathways related to Headache according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9CALCA, EDNRA
29.9CALCA, HCRTR2
3
Show member pathways
9.3EDNRA, HCRTR2, HTR2A
4
Show member pathways
9.3HTR1B, HTR2A
59.2CACNA1A, HTR2A, EDNRA
6
Show member pathways
phenylalanine utilization39
noradrenaline and adrenaline degradation39
phenylalanine degradation IV39
9.1ADH7, ADH4
7
Show member pathways
9.1ADH7, ADH4
89.0HTR3A, HTR1B, HTR2A
9
Show member pathways
8.5HTR2A, HTR1B, HTR3A, CACNA1A
10
Show member pathways
8.5HTR2A, HTR1B, HTR3A, CACNA1A
11
Show member pathways
8.4EDNRA, HCRTR2, HTR2A, HTR1B, CALCA
12
Show member pathways
8.1EDNRA, HCRTR2, VIP, HTR2A, HTR1B, CALCA

Compounds for genes affiliated with Headache

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Sources:
46Novoseek, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB, 52PharmGKB, 3BitterDB
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Compounds related to Headache according to GeneCards/GeneDecks:

(show top 50)    (show all 152)
idCompoundScoreTop Affiliating Genes
1n(g)-nitro-l-arginine methyl ester469.9VIP, CALCA, EDNRA
2mdl 100907469.8HTR3A, HTR2A
3phosphoramidon46 1210.8EDNRA, VIP, CALCA
4mdl 72222469.8HTR3A, HTR2A
5alpha methyl 5 hydroxytryptamine469.8HTR2A, HTR3A
6ly 53857469.8HTR3A, HTR2A
7triptan469.7CALCA, HTR1B, HTR3A
8alpha-methylserotonin469.6HTR2A, HTR3A
9tetrodotoxin46 62 3011.6EDNRA, CALCA, VIP, HTR3A
10(tfmpp)469.4HTR2A, HTR3A, HTR1B
111-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane469.4HTR1B, HTR2A, HTR3A
12cyanopindolol46 3010.4HTR3A, HTR1B, HTR2A
13ru 2496930 4610.4HTR2A, HTR3A, HTR1B
142-methyl-5-ht46 3010.4HTR1B, HTR3A, HTR2A
15mcpp469.4HTR1B, HTR2A, HTR3A
165-carboxamidotryptamine469.4HTR3A, HTR1B, HTR2A
17ipsapirone46 3010.4HTR1B, HTR2A, HTR3A
18pindolol46 30 1211.4HTR1B, HTR2A, HTR3A
19dihydroergotamine46 30 1211.4HTR3A, HTR1B, HTR2A
20zotepine46 3010.4HTR3A, HTR2A, HTR1B
21methiothepin46 3010.4HTR3A, HTR1B, HTR2A
22ritanserin46 3010.4HTR3A, HTR1B, HTR2A
23metergoline46 3010.4HTR1B, HTR2A, HTR3A
24methysergide46 30 1211.4HTR1B, HTR2A, HTR3A
25tryptamine46 30 2511.4HTR3A, HTR1B, HTR2A
26nefazodone46 52 1211.4HTR3A, HTR1B, HTR2A
27fenfluramine46 30 1211.3HTR3A, HTR1B, HTR2A
28ergotamine30 46 1211.3HTR3A, HTR2A, HTR1B
29ketanserin46 3010.3HTR3A, HTR1B, HTR2A
30Serotonin259.3HTR2A, HTR3A, HTR1B
31venlafaxine46 52 25 1212.3HTR1B, HTR3A, HTR2A
32phenylbiguanide469.3HTR2A, HTR3A
33clomipramine46 52 1211.3HTR2A, HTR1B, HTR3A
34ondansetron52 46 25 1212.3HTR2A, HTR1B, HTR3A
35aripiprazole30 46 52 25 1213.3HTR1B, HTR3A, HTR2A
36ziprasidone30 52 46 1212.3HTR2A, HTR1B, HTR3A
37yohimbine46 3 30 1212.3HTR1B, HTR3A, HTR2A
38propranolol46 30 52 25 1213.2HTR3A, CALCA, HTR1B, VIP
39paroxetine46 52 30 1212.2HTR3A, HTR1B, HTR2A
40histamine46 30 2511.2HCRTR2, EDNRA, VIP, HTR3A, CALCA
41acth469.2HP, HCRTR2, CALCA, VIP
42quetiapine46 52 30 25 1213.1HTR3A, HTR1B, HTR2A
43adenylate469.0CALCA, HP, HTR3A, VIP, EDNRA
44bromocriptine46 30 1211.0HTR1B, VIP, HTR2A
45acetylcholine46 52 30 25 1212.8EDNRA, HCRTR2, VIP, HTR3A, CACNA1A, CALCA
46norepinephrine46 25 1210.8EDNRA, CALCA, HTR3A, HTR2A, VIP, HCRTR2
47sumatriptan46 30 62 52 25 1213.8HTR1B, HTR2A, CALCA, HTR3A, VIP
485-hydroxytryptamine468.8CALCA, HTR3A, HTR1B, HTR2A, VIP
49dopamine46 30 25 1211.5CALCA, EDNRA, VIP, HTR2A, HTR1B, HTR3A
50testosterone46 62 25 1211.4HTR1B, HP, EDNRA, VIP, CALCA

GO Terms for genes affiliated with Headache

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Sources:
17Gene Ontology
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Cellular components related to Headache according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:0430258.4CALCA, CACNA1A, HTR3A, HTR2A, VIP
2integral component of plasma membraneGO:0058878.1EDNRA, HCRTR2, HTR2A, HTR1B, HTR3A
3plasma membraneGO:0058867.9CACNA1A, HTR3A, HTR1B, HTR2A, HCRTR2, EDNRA

Biological processes related to Headache according to GeneCards/GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling paGO:05148210.1CALCA, EDNRA
2artery smooth muscle contractionGO:01482410.0HTR2A, EDNRA
3activation of adenylate cyclase activityGO:00719010.0CALCA, EDNRA
4detection of temperature stimulus involved in sensory perception of painGO:05096510.0CALCA, HTR2A
5positive regulation of vasodilationGO:04590910.0VIP, CALCA
6feeding behaviorGO:0076319.9CALCA, HCRTR2
7serotonin receptor signaling pathwayGO:0072109.9HTR2A, HTR3A
8regulation of blood pressureGO:0082179.9CALCA, EDNRA
9negative regulation of potassium ion transportGO:0432679.9VIP, HTR2A
10negative regulation of cAMP biosynthetic processGO:0308189.9EDNRA, HTR1B
11G-protein coupled receptor internalizationGO:0020319.8HTR1B, CALCA
12vasoconstrictionGO:0423109.8EDNRA, HTR1B
13positive regulation of cytosolic calcium ion concentrationGO:0072049.8EDNRA, CACNA1A, CALCA
14agingGO:0075689.7CALCA, HTR2A, EDNRA
15response to cocaineGO:0422209.7HTR3A, HTR1B
16regulation of dopamine secretionGO:0140599.7HTR1B, HTR2A
17negative regulation of synaptic transmission, glutamatergicGO:0519679.7HTR2A, HTR1B
18regulation of behaviorGO:0507959.6HTR2A, HTR1B
19protein kinase C-activating G-protein coupled receptor signaling pathwayGO:0072059.6EDNRA, HTR1B
20ethanol oxidationGO:0060699.4ADH4, ADH7
21activation of phospholipase C activityGO:0072029.4HTR2A, EDNRA
22retinol metabolic processGO:0425729.3ADH7, ADH4
23response to ethanolGO:0454719.0ADH7, HTR1B, HTR3A
24retinoid metabolic processGO:0015239.0ADH7, ADH4
25synaptic transmissionGO:0072688.6CACNA1A, HTR3A, HTR1B, HTR2A, HCRTR2

Molecular functions related to Headache according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1ethanol bindingGO:0352769.2ADH7, ADH4
2serotonin bindingGO:0513789.1HTR3A, HTR1B, HTR2A
3alcohol dehydrogenase activity, zinc-dependentGO:0040249.1ADH4, ADH7
4retinol dehydrogenase activityGO:0047459.1ADH7, ADH4
5serotonin receptor activityGO:0049939.1HTR3A, HTR1B, HTR2A
6alcohol dehydrogenase (NAD) activityGO:0040229.0ADH7, ADH4
7retinol bindingGO:0198418.8ADH7, ADH4

Products for genes affiliated with Headache

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Headache

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet