MCID: HDC001
MIFTS: 50

Headache malady

Neuronal diseases category

Summaries for Headache

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MedlinePlus:32 Almost everyone has had a headache. headache is the most common form of pain. it's a major reason people miss days at work or school or visit the doctor. the most common type of headache is a tension headache. tension headaches are due to tight muscles in your shoulders, neck, scalp and jaw. they are often related to stress, depression or anxiety. you are more likely to get tension headaches if you work too much, don't get enough sleep, miss meals, or use alcohol. other common types of headaches include migraines, cluster headaches, and sinus headaches. most people can feel much better by making lifestyle changes, learning ways to relax and taking pain relievers. not all headaches require a doctor's attention. but sometimes headaches warn of a more serious disorder. let your health care provider know if you have sudden, severe headaches. get medical help right away if you have a headache after a blow to your head, or if you have a headache along with a stiff neck, fever, confusion, loss of consciousness, or pain in the eye or ear. nih: national institute of neurological disorders and stroke

MalaCards based summary: Headache is related to cluster headache and familial hemiplegic migraine. An important gene associated with Headache is EDNRA (endothelin receptor type A), and among its related pathways are Endothelin and Adenylate cyclase activating neuropeptides. The compounds n(g)-nitro-l-arginine methyl ester and mdl 100907 have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and pituitary, and related mouse phenotypes are cardiovascular system and endocrine/exocrine gland.

NINDS:42 There are four types of headache:

Wikipedia:63 A headache or cephalalgia is pain anywhere in the region of the head or neck. It can be a symptom of a... more...

Aliases & Classifications for Headache

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Related Diseases for Headache

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Diseases related to Headache via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 598)
idRelated DiseaseScoreTop Affiliating Genes
1cluster headache31.5HCRTR2, VIP, HTR3A, CACNA1A, CALCA
2familial hemiplegic migraine30.9CACNA1A
3migraine30.5CALCA, EDNRA, VIP, HTR2A, HTR1B, HTR3A
4fibromyalgia30.4HTR2A, HTR3A
5generalized anxiety disorder30.4HTR2A, HTR3A
6rhinitis30.3EDNRA, VIP
7pheochromocytoma30.2EDNRA, HCRTR2, VIP, CALCA
8serotonin syndrome30.2HTR2A, HTR3A
9substance abuse30.2ADH4
10anxiety disorder30.1HTR2A, HTR3A
11coronary artery disease30.1HP, HTR3A, EDNRA
12impotence30.1EDNRA, VIP
13constipation30.1VIP, HTR3A
14bipolar disorder30.0HTR3A, HTR2A
15congenital heart disease30.0VIP, HTR2A, HP
16eating disorder29.9HTR2A, HTR3A
17panic disorder29.9HTR2A, HTR3A
18stroke, ischemic29.8HTR3A, HTR2A, VIP, EDNRA
19mood disorder29.6HTR2A, HTR1B, HTR3A
20carcinoid syndrome29.6CALCA, HTR3A, HTR2A, VIP
21arthritis29.5CALCA, HP, VIP
22thunderclap headache10.8
23hypnic headache10.7
24new daily-persistent headache10.7
25intracranial hypotension10.6
26cerebritis10.6
27exertional headache10.6
28cough headache10.6
29hemicrania continua10.5
30paroxysmal hemicrania10.5
31vipoma10.5VIP
32intracranial hypertension10.5
33cervicitis10.4
34carotid artery dissection10.4
35meningitis10.4
36aneurysm10.4
37migraine with aura10.4
38sinusitis10.4
39occipital neuralgia10.4
40reversible cerebral vasoconstriction syndrome10.4
41islet cell tumor10.3CALCA, VIP
42bruxism10.3
43papilledema10.3
44somatostatinoma10.3VIP, CALCA
45patent foramen ovale10.3
46whiplash10.3
47blindness10.3
48sunct headache10.3
49neuroendocrine tumor10.3VIP, CALCA
50multiple endocrine neoplasia10.3CALCA, VIP

Graphical network of the top 20 diseases related to Headache:



Diseases related to headache

Symptoms for Headache

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Drugs & Therapeutics for Headache

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Drug clinical trials:

Search ClinicalTrials for Headache

Search NIH Clinical Center for Headache

Genetic Tests for Headache

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Anatomical Context for Headache

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MalaCards organs/tissues related to Headache:

31
Brain, Eye, Pituitary, Testes, Hypothalamus, Heart, Spinal cord, Pineal, Lung, Cortex, Cerebellum, Colon, Kidney, Liver, Skin, Ovary, Temporal lobe, Thalamus, Amygdala, Dorsal root ganglion, Neutrophil

Animal Models for Headache or affiliated genes

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MGI Mouse Phenotypes related to Headache:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.5CALCA, HP, HTR1B, VIP, EDNRA
2MP:00053798.2EDNRA, VIP, HTR2A, HTR1B, HTR3A
3MP:00053698.0EDNRA, HCRTR2, HTR2A, HTR1B, HTR3A, CACNA1A
4MP:00036317.6EDNRA, HCRTR2, ADH7, HTR3A, CACNA1A, CALCA
5MP:00053767.6EDNRA, VIP, ADH7, HTR3A, HP, CACNA1A
6MP:00107687.5EDNRA, VIP, ADH7, HTR3A, HP, CACNA1A
7MP:00053866.9CALCA, HCRTR2, VIP, ADH7, HTR2A, HTR1B

Publications for Headache

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Articles related to Headache:

(show top 50)    (show all 2029)
idTitleAuthorsYear
1
Abnormal coactivation of the hypothalamus and salience network in patients with cluster headache. (25746559)
2015
2
Study of cluster headache: A hospital-based study. (25288839)
2014
3
Discussion: nonendoscopic deactivation of nerve triggers in migraine headache patients: surgical technique and outcomes. (25357036)
2014
4
Corticosteroids alter CGRP and melatonin release in cluster headache episodes. (24958681)
2014
5
Peripheral Nerve Field Stimulation for Chronic Headache: 60 Cases and Long-Term Follow-Up. (24165152)
2013
6
Two-tiered approach to MRI for headache: a cost-effective way to use an expensive technology. (23789700)
2013
7
Effective surgical revascularization improves cerebral hemodynamics and resolves headache in pediatric Moyamoya disease. (23022638)
2013
8
Headache and vasculitis. (23338772)
2013
9
Monthly variation of United States pediatric headache emergency department visits. (24335850)
2013
10
Postcraniotomy headache. (23846599)
2013
11
Relationship between headache and mucosal mast cells in pediatric Helicobacter pylori-negative functional dyspepsia. (23291287)
2013
12
A case of cluster headache treated with rotigotine: clinical and neurophysiological correlates. (23709498)
2013
13
Impact of continuing or quitting smoking on episodic cluster headache: a pilot survey. (23742010)
2013
14
Thunderclap headache: diagnostic considerations and neuroimaging features. (23245274)
2013
15
Headache and comorbidity in children and adolescents. (24063537)
2013
16
Headache in school children: prevalence and risk factors. (24333367)
2013
17
Prediction of headache severity (density and functional impact) after traumatic brain injury: A longitudinal multicenter study. (23575819)
2013
18
Epidemiology and clinical characteristics of chronic daily headache in a clinic-based cohort of Iranian population. (24068481)
2013
19
Advice alone versus structured detoxification programmes for complicated medication overuse headache (MOH): a prospective, randomized, open-label trial. (23565591)
2013
20
Sedative dosing of propofol for treatment of migraine headache in the emergency department: a case series. (24381692)
2013
21
Stimulation of the sphenopalatine ganglion (SPG) for cluster headache treatment. Pathway CH-1: A randomized, sham-controlled study. (23314784)
2013
22
Occipital nerve stimulation for medically refractory hypnic headache. (22376140)
2012
23
Ischemic stroke presenting as thunderclap headache: report of two cases and review of the literature. (21865762)
2011
24
Neuromodulation of the posterolateral hypothalamus for the treatment of chronic refractory cluster headache: Experience in five patients with a modified anatomical target. (22116943)
2011
25
A patient with superficial siderosis, intraspinal cyst, low-pressure headache and low-lying cord. (22368982)
2011
26
Bruxism, temporomandibular dysfunction, tension-type headache, and migraine. (21762137)
2011
27
Levels of nitric oxide metabolites in cerebrospinal fluid in cluster headache. (20511209)
2010
28
Post-infectious new daily persistent headache may respond to intravenous methylprednisolone. (19936615)
2010
29
Cardiac cephalalgia presented with a thunderclap headache and an isolated exertional headache: report of 2 cases. (20714954)
2010
30
Oxygen treatment in acute cluster headache. (19272273)
2009
31
Genetic aspects of cluster headache. (19271945)
2009
32
Medical image. Severe headache when standing. Intracranial hypotension. (19319177)
2009
33
Cerebral non-Langerhans cell histiocytosis in a 17-year-old patient with a headache: case report. (19363626)
2009
34
Cluster headache during pregnancy: case report and literature review. (19125883)
2009
35
Prevalence of cluster headache in the Republic of Georgia: results of a population-based study and methodological considerations. (19250289)
2009
36
Resolution of diplopia with late treatment of post-dural puncture headache and intracranial hypotension. (18378978)
2008
37
Involvement of corticotrophin-releasing factor and orexin-A in chronic migraine and medication-overuse headache: findings from cerebrospinal fluid. (18479471)
2008
38
Elevation of CSF tumor necrosis factor alpha levels in new daily persistent headache and treatment refractory chronic migraine. (17635596)
2007
39
G protein beta3 polymorphism and triptan response in cluster headache. (17361120)
2007
40
Headache in a patient with Klinefelter's syndrome and hyperostosis frontalis interna. (18071629)
2007
41
The headache-inducing effect of cilostazol in human volunteers. (17059437)
2006
42
A genome-wide scan and HCRTR2 candidate gene analysis in a European cluster headache cohort. (16801656)
2006
43
Valdecoxib for treatment of a single, acute, moderate to severe migraine headache. (16178945)
2005
44
Systemic autonomic involvement in episodic cluster headache: a comparison between active and remission periods. (16362675)
2005
45
Differentiating paroxysmal hemicrania from cluster headache. (15773820)
2005
46
Impairment of trigeminal sensory pathways in cluster headache. (15377328)
2004
47
Sensory nerves in man and their role in primary headaches. (11595008)
2001
48
Antinuclear and anticardiolipin antibodies in primary headache syndromes]. (12799962)
1998
49
The insulin tolerance test and the ovine corticotrophin-releasing hormone test in episodic cluster headache. (1665104)
1991
50
A new etiology for visual impairment and chronic headache. The Tolosa-Hunt syndrome may be only one manifestation of venous vasculitis. (3698095)
1986

Variations for Headache

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Expression for genes affiliated with Headache

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Search GEO for disease gene expression data for Headache.

Pathways for genes affiliated with Headache

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Pathways related to Headache according to GeneCards Suite gene sharing:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9CALCA, EDNRA
2
Show member pathways
9.3EDNRA, HCRTR2, HTR2A
3
Show member pathways
9.3HTR1B, HTR2A
49.2CACNA1A, HTR2A, EDNRA
5
Show member pathways
phenylalanine utilization36
noradrenaline and adrenaline degradation36
phenylalanine degradation IV36
9.1ADH7, ADH4
6
Show member pathways
9.1ADH7, ADH4
79.0HTR3A, HTR1B, HTR2A
8
Show member pathways
8.5HTR2A, HTR1B, HTR3A, CACNA1A
9
Show member pathways
8.5HTR2A, HTR1B, HTR3A, CACNA1A
10
Show member pathways
8.4EDNRA, HCRTR2, HTR2A, HTR1B, CALCA
11
Show member pathways
8.1EDNRA, HCRTR2, VIP, HTR2A, HTR1B, CALCA

Compounds for genes affiliated with Headache

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Compounds related to Headache according to GeneCards Suite gene sharing:

(show top 50)    (show all 152)
idCompoundScoreTop Affiliating Genes
1n(g)-nitro-l-arginine methyl ester439.9VIP, CALCA, EDNRA
2mdl 100907439.8HTR3A, HTR2A
3phosphoramidon43 1210.8EDNRA, VIP, CALCA
4mdl 72222439.8HTR3A, HTR2A
5alpha methyl 5 hydroxytryptamine439.8HTR2A, HTR3A
6ly 53857439.8HTR3A, HTR2A
7triptan439.7CALCA, HTR1B, HTR3A
8alpha-methylserotonin439.6HTR2A, HTR3A
9tetrodotoxin43 59 2811.6EDNRA, CALCA, VIP, HTR3A
10(tfmpp)439.4HTR2A, HTR3A, HTR1B
111-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane439.4HTR1B, HTR2A, HTR3A
12cyanopindolol43 2810.4HTR3A, HTR1B, HTR2A
13ru 2496928 4310.4HTR2A, HTR3A, HTR1B
142-methyl-5-ht43 2810.4HTR1B, HTR3A, HTR2A
15mcpp439.4HTR1B, HTR2A, HTR3A
165-carboxamidotryptamine439.4HTR3A, HTR1B, HTR2A
17ipsapirone43 2810.4HTR1B, HTR2A, HTR3A
18pindolol43 28 1211.4HTR1B, HTR2A, HTR3A
19dihydroergotamine43 28 1211.4HTR3A, HTR1B, HTR2A
20zotepine43 2810.4HTR3A, HTR2A, HTR1B
21methiothepin43 2810.4HTR3A, HTR1B, HTR2A
22ritanserin43 2810.4HTR3A, HTR1B, HTR2A
23metergoline43 2810.4HTR1B, HTR2A, HTR3A
24methysergide43 28 1211.4HTR1B, HTR2A, HTR3A
25tryptamine43 28 2411.4HTR3A, HTR1B, HTR2A
26nefazodone43 49 1211.4HTR3A, HTR1B, HTR2A
27fenfluramine43 28 1211.3HTR3A, HTR1B, HTR2A
28ergotamine28 43 1211.3HTR3A, HTR2A, HTR1B
29ketanserin43 2810.3HTR3A, HTR1B, HTR2A
30Serotonin249.3HTR2A, HTR3A, HTR1B
31venlafaxine43 49 24 1212.3HTR1B, HTR3A, HTR2A
32phenylbiguanide439.3HTR2A, HTR3A
33clomipramine43 49 1211.3HTR2A, HTR1B, HTR3A
34ondansetron49 43 24 1212.3HTR2A, HTR1B, HTR3A
35aripiprazole28 43 49 24 1213.3HTR1B, HTR3A, HTR2A
36ziprasidone28 49 43 1212.3HTR2A, HTR1B, HTR3A
37yohimbine43 2 28 1212.3HTR1B, HTR3A, HTR2A
38propranolol43 28 49 24 1213.2HTR3A, CALCA, HTR1B, VIP
39paroxetine43 49 28 1212.2HTR3A, HTR1B, HTR2A
40histamine43 28 2411.2HCRTR2, EDNRA, VIP, HTR3A, CALCA
41acth439.2HP, HCRTR2, CALCA, VIP
42quetiapine43 49 28 24 1213.1HTR3A, HTR1B, HTR2A
43adenylate439.0CALCA, HP, HTR3A, VIP, EDNRA
44bromocriptine43 28 1211.0HTR1B, VIP, HTR2A
45acetylcholine43 49 28 24 1212.8EDNRA, HCRTR2, VIP, HTR3A, CACNA1A, CALCA
46norepinephrine43 24 1210.8EDNRA, CALCA, HTR3A, HTR2A, VIP, HCRTR2
47sumatriptan43 28 59 49 24 1213.8HTR1B, HTR2A, CALCA, HTR3A, VIP
485-hydroxytryptamine438.8CALCA, HTR3A, HTR1B, HTR2A, VIP
49dopamine43 28 24 1211.5CALCA, EDNRA, VIP, HTR2A, HTR1B, HTR3A
50testosterone43 59 24 1211.4HTR1B, HP, EDNRA, VIP, CALCA

GO Terms for genes affiliated with Headache

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Cellular components related to Headache according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1neuronal cell bodyGO:00430258.4CALCA, CACNA1A, HTR3A, HTR2A, VIP
2integral component of plasma membraneGO:00058878.1EDNRA, HCRTR2, HTR2A, HTR1B, HTR3A
3plasma membraneGO:00058867.9CACNA1A, HTR3A, HTR1B, HTR2A, HCRTR2, EDNRA

Biological processes related to Headache according to GeneCards Suite gene sharing:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling paGO:005148210.1CALCA, EDNRA
2artery smooth muscle contractionGO:001482410.0HTR2A, EDNRA
3activation of adenylate cyclase activityGO:000719010.0CALCA, EDNRA
4detection of temperature stimulus involved in sensory perception of painGO:005096510.0CALCA, HTR2A
5positive regulation of vasodilationGO:004590910.0VIP, CALCA
6feeding behaviorGO:00076319.9CALCA, HCRTR2
7serotonin receptor signaling pathwayGO:00072109.9HTR2A, HTR3A
8regulation of blood pressureGO:00082179.9CALCA, EDNRA
9negative regulation of potassium ion transportGO:00432679.9VIP, HTR2A
10negative regulation of cAMP biosynthetic processGO:00308189.9EDNRA, HTR1B
11G-protein coupled receptor internalizationGO:00020319.8HTR1B, CALCA
12vasoconstrictionGO:00423109.8EDNRA, HTR1B
13positive regulation of cytosolic calcium ion concentrationGO:00072049.8EDNRA, CACNA1A, CALCA
14agingGO:00075689.7CALCA, HTR2A, EDNRA
15response to cocaineGO:00422209.7HTR3A, HTR1B
16regulation of dopamine secretionGO:00140599.7HTR1B, HTR2A
17negative regulation of synaptic transmission, glutamatergicGO:00519679.7HTR2A, HTR1B
18regulation of behaviorGO:00507959.6HTR2A, HTR1B
19protein kinase C-activating G-protein coupled receptor signaling pathwayGO:00072059.6EDNRA, HTR1B
20ethanol oxidationGO:00060699.4ADH4, ADH7
21activation of phospholipase C activityGO:00072029.4HTR2A, EDNRA
22retinol metabolic processGO:00425729.3ADH7, ADH4
23response to ethanolGO:00454719.0ADH7, HTR1B, HTR3A
24retinoid metabolic processGO:00015239.0ADH7, ADH4
25synaptic transmissionGO:00072688.6CACNA1A, HTR3A, HTR1B, HTR2A, HCRTR2

Molecular functions related to Headache according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1ethanol bindingGO:00352769.2ADH7, ADH4
2serotonin bindingGO:00513789.1HTR3A, HTR1B, HTR2A
3alcohol dehydrogenase activity, zinc-dependentGO:00040249.1ADH4, ADH7
4retinol dehydrogenase activityGO:00047459.1ADH7, ADH4
5serotonin receptor activityGO:00049939.1HTR3A, HTR1B, HTR2A
6alcohol dehydrogenase (NAD) activityGO:00040229.0ADH7, ADH4
7retinol bindingGO:00198418.8ADH7, ADH4

Products for genes affiliated with Headache

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Sources for Headache

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet