MCID: HDC001
MIFTS: 58

Headache malady

Neuronal category

Summaries for Headache

Sources:
34MedlinePlus, 44NINDS, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Almost everyone has had a headache. headache is the most common form of pain. it's a major reason people miss days at work or school or visit the doctor. the most common type of headache is a tension headache. tension headaches are due to tight muscles in your shoulders, neck, scalp and jaw. they are often related to stress, depression or anxiety. you are more likely to get tension headaches if you work too much, don't get enough sleep, miss meals, or use alcohol. other common types of headaches include migraines, cluster headaches, and sinus headaches. most people can feel much better by making lifestyle changes, learning ways to relax and taking pain relievers. not all headaches require a doctor's attention. but sometimes headaches warn of a more serious disorder. let your health care provider know if you have sudden, severe headaches. get medical help right away if you have a headache after a blow to your head, or if you have a headache along with a stiff neck, fever, confusion, loss of consciousness, or pain in the eye or ear. nih: national institute of neurological disorders and stroke

MalaCards: Headache is related to cluster headache and sleep disorder. An important gene associated with Headache is EDNRA (endothelin receptor type A), and among its related pathways are Endothelin and G alpha (q) signalling events. The compounds acetylcholine and sumatriptan have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver, and related mouse phenotypes are behavior/neurological and renal/urinary system.

NINDS:44 There are four types of headache:

Wikipedia:64 A headache or cephalgia is pain anywhere in the region of the head or neck. It can be a symptom of a... more...

Aliases & Classifications for Headache

Sources:
44NINDS, 34MedlinePlus, 25ICD10
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Related Diseases for Headache

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Headache via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 511)
idRelated DiseaseScoreTop Affiliating Genes
1cluster headache31.7PNOC, HCRTR2, HTR3A, CACNA1A, CALCA, VIP
2sleep disorder30.3HCRTR2, CLOCK
3cadasil30.2VIP, GNB3, HTR3A, HTR2A, EDNRA, PF4
4familial hemiplegic migraine30.2CACNA1A
5vasculitis30.1S100A12
6fibromyalgia30.0HTR3A, HTR2A, NPY, PNOC
7pheochromocytoma30.0VIP, CALCA, NPY, EDNRA, HCRTR2
8generalized anxiety disorder29.9HTR2A, HTR3A
9chronic fatigue syndrome29.9VIP
10phaeochromocytoma29.9CALCA, NPY
11acute myocardial infarction29.8HTR3A, HTR2A, PF4
12uremia29.8PF4
13anxiety disorder29.8NPY, HTR2A, HTR3A
14coronary artery disease,29.8GNB3, HTR3A, HP, PF4
15arthritis29.6VIP, CALCA, S100A12, HP
16substance abuse29.6ADH4
17anorexia nervosa29.6NPY, HTR2A, HTR3A
18coronary heart disease29.6GNB3, HTR3A, NPY, AKR1A1, PF4
19dyspepsia29.6HTR3A
20panic disorder29.6HTR3A, HTR2A
21carcinoid syndrome29.6VIP, CALCA, HTR3A, HTR2A
22paraganglioma29.6CALCA
23adenocarcinoma29.6PF4, EDNRA, VIP
24migraine without aura29.6NPY, CACNA1A
25asthma29.6VIP, S100A12, HTR2A, EDNRA
26bipolar disorder29.6HTR3A, HTR2A
27status epilepticus29.6NPY
28parkinson's disease29.6HTR1B, HTR3A, HTR2A, AKR1A1
29thunderclap headache10.8
30hypnic headache10.7
31intracranial hypotension10.6
32exertional headache10.6
33cough headache10.6
34paroxysmal hemicrania10.5
35hemicrania continua10.5
36n syndrome10.4
37carotid artery dissection10.4
38occipital neuralgia10.3
39head injury10.3
40venous thrombosis10.3
41patent foramen ovale10.3
42sunct headache10.3
43whiplash10.3
44bruxism10.3
45sinusitis10.3
46temporal arteritis10.3
47cerebrospinal fluid leak10.3
48new daily-persistent headache10.2
49pseudotumor cerebri10.2
50acoustic neuroma10.2

Graphical network of the top 20 diseases related to Headache:



Diseases related to headache

Clinical Features for Headache

Drugs & Therapeutics for Headache

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Headache

Drug clinical trials:

Search ClinicalTrials for Headache

Search NIH Clinical Center for Headache

Search CenterWatch for Headache

Genetic Tests for Headache

Anatomical Context for Headache

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Headache:

33
Skin, Ovary, Liver, Spinal cord, Brain, Lung, Whole blood, Cortex, Cerebellum, Heart, Colon, T cells, B lymphoblasts, B cells, Endothelial, Parietal lobe, Temporal lobe, Occipital lobe, Thalamus, Hypothalamus, Amygdala, Dorsal root ganglion, Trigeminal ganglion, Pineal, Pituitary

Animal Models for Headache or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Headache

Sources:
51PubMed
See all sources

Articles related to Headache:

(show top 50)    (show all 1900)
idTitleAuthorsYear
1
Peripheral neuromodulation for treatment of chronic migraine headache. (24262895)
2014
2
Recumbent Thunderclap Headache in the Postpartum Period. (24413232)
2014
3
Sleep-related headache and its management. (24132786)
2013
4
Cluster headache: what has changed since 1999? (23695050)
2013
5
Ambulatory blood pressure monitoring in patient with hypnic headache: a case study. (23425041)
2013
6
Clinical Inquiry: What clinical clues differentiate migraine from sinus headaches? (24340338)
2013
7
Isolated sinusitis sphenoidalis caused by Trichoderma longibrachiatum in an immunocompetent patient with headache. (23657526)
2013
8
Assessment of Medicare's imaging efficiency measure for emergency department patients with atraumatic headache. (23684333)
2013
9
The Yekaterinburg headache initiative: an interventional project, within the Global Campaign against Headache, to reduce the burden of headache in Russia. (24367919)
2013
10
A 46-year-old woman with a history of personality change, headache, and olfactory hallucination. (24250909)
2013
11
Image diagnosis: headache and an isolated oculomotor nerve palsy. (24355902)
2013
12
Harlequin syndrome: does a cranial autonomic neuropathy influence headache? (22523398)
2012
13
A novel CACNA1A mutation results in episodic ataxia with migrainous features without headache. (22942164)
2012
14
Case 15-2012: Diplopia, headaches, and papilledema. (22894593)
2012
15
Economic evaluation of "pulse dose" radiofrequency in the treatment of occipital neuralgia headache. (23905049)
2012
16
A patient with cluster headache--due to a brainstem lesion. (22077341)
2012
17
Efficacy of hypothalamic stimulation for chronic drug-resistant cluster headache. (22259048)
2012
18
Headache in patients with pituitary adenoma: clinical and paraclinical findings. (23059488)
2012
19
High-altitude headache and acute mountain sickness. (22703629)
2012
20
Bruxism, temporomandibular dysfunction, tension-type headache, and migraine. (21762137)
2011
21
Acute and preventive pharmacologic treatment of cluster headache. (21980606)
2011
22
An unusual cause of symptomatic tension-type headache: hypertrophic branchial myopathy. (22067972)
2011
23
Topical review: cluster headache and sleep-related breathing disorders. (22247924)
2011
24
Warfarin for refractory chronic cluster headache: a randomized pilot study. (21395575)
2011
25
Licorice consumption-associated thunderclap headache: posterior reversible encephalopathy syndrome or subarachnoid hemorrhage? (21463535)
2011
26
Invalidating headaches as a symptom of pulmonary embolism in a Dandy-Walker syndrome with ventriculoatrial shunt. (21749565)
2011
27
Can response to indomethacin exclude the diagnosis of cluster headache? (20656700)
2010
28
Cluster headache: diagnosis and treatment. (20352587)
2010
29
Oxygen treatment in acute cluster headache. (19272273)
2009
30
Exertional headache as unusual presentation of the syndrome of an elongated styloid process. (19456886)
2009
31
Epidemiology of cluster headache. (19272280)
2009
32
Reduced habituation of trigeminal reflexes in patients with episodic cluster headache during cluster period. (18624808)
2008
33
Postpartum thunderclap headache. (18981445)
2008
34
Cluster headache with Brugada electrocardiogram pattern: a case report. (18563291)
2008
35
Headache in a patient with Klinefelter's syndrome and hyperostosis frontalis interna. (18071629)
2007
36
Two symptomatic cases of cluster headache associated with internal carotid artery dissection. (17508178)
2007
37
Non-REM hypnic headache: a circadian disorder? A clinical and polysomnographic study. (17212689)
2007
38
Infections and training headaches plague UK's government health system. (17927038)
2007
39
Testosterone replacement therapy for treatment refractory cluster headache. (16732838)
2006
40
Trigeminal nerve radiosurgical treatment in intractable chronic cluster headache: unexpected high toxicity. (17277687)
2006
41
Study of hypothalamic metabolism in cluster headache by proton MR spectroscopy. (16636250)
2006
42
Triptan responsive hypnic headache? (16796594)
2006
43
Patterns and predictors of prescription medication use in the management of headache: findings from the 2000 Medical Expenditure Panel Survey. (16178947)
2005
44
Possible mechanisms of pain perception in patients with episodic tension-type headache. A new experimental model of myofascial pain. (15154856)
2004
45
Anginal cephalgia: a serious form of exertional headache. (15009018)
2004
46
CACNA1A gene polymorphisms in cluster headache. (11843866)
2001
47
Cough headache associated with Chiari type-I malformation: responsiveness to indomethacin. (11037749)
2000
48
Idiopathic intracranial hypertension without papilledema: a case-control study in a headache center. (9674810)
1998
49
Leukocyte subsets and cortisol serum levels in patients with migraine without aura and chronic tension-type headache. (8062352)
1994
50
Advances in understanding the pathophysiology of headache. (1557193)
1992

Genetic Variations for Headache

Expression for genes affiliated with Headache

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Headache

Search GEO for disease gene expression data for Headache.

Pathways for genes affiliated with Headache

Sources:
38NCBI BioSystems Database, 54Reactome, 30KEGG, 52QIAGEN, 50PharmGKB, 12EMD Millipore
See all sources

Pathways related to Headache according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5EDNRA, NPY, CALCA
2
Hide members
10.5GNB3, HTR2A, EDNRA, HCRTR2
3
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10.5ADH7, ADH4
4
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10.5ADH7, ADH4
5
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10.5VIP, CALCA, GNB3, HTR1B, HTR2A, HTR1D
6
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10.5HTR1D, HTR2A, HTR3A, HTR1B, GNB3, CACNA1A
7
Hide members
10.5HTR1B, HTR3A, HTR2A, HTR1D
8
Hide members
10.5CACNA1A, GNB3, HTR1B, HTR3A, HTR2A, HTR1D
9
Hide members
10.5PNOC, CALCA, GNB3, HTR1B, HTR2A, HTR1D
10
Hide members
10.5ADH7, ADH4, AKR1A1
11
Hide members
10.5AKR1A1, ADH4, ADH7

Compounds for genes affiliated with Headache

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Headache according to GeneCards/GeneDecks:

(show top 50)    (show all 190)
idCompoundScoreTop Affiliating Genes
1acetylcholine45 50 29 11 2414.9PNOC, CALCA, CACNA1A, HTR3A, EDNRA, HCRTR2
2sumatriptan45 29 60 50 11 2415.9VIP, HTR2A, HTR3A, HTR1B, GNB3, CALCA
3norepinephrine45 11 2412.9EDNRA, PNOC, PF4, VIP, CALCA, GNB3
4histamine45 29 2412.9HCRTR2, VIP, PNOC, HTR3A, CALCA, NPY
5adenylate4510.9NPY, HTR1D, HTR3A, CALCA, VIP, AKR1A1
65-hydroxytryptamine4510.9PF4, NPY, HTR1D, HTR2A, HTR3A, HTR1B
7cyanopindolol45 2911.9HTR2A, HTR1B, HTR3A, HTR1D
8dopamine45 29 11 2413.9PNOC, VIP, HTR3A, HTR2A, HTR1D, NPY
9ru 2496929 4511.9HTR2A, HTR1B, HTR3A, HTR1D
10yohimbine45 29 2 1113.9HTR1D, NPY, HTR3A, HTR1B, HTR2A
112-methyl-5-ht45 2911.9HTR2A, HTR3A, HTR1D, HTR1B
12guanethidine45 1111.9VIP, NPY, PNOC, CALCA
135-carboxamidotryptamine4510.9HTR3A, HTR2A, HTR1D, HTR1B
14ipsapirone45 2911.9HTR1B, HTR3A, HTR2A, HTR1D
15haloperidol45 29 2 50 1114.9NPY, VIP, HTR1D, HTR2A, AKR1A1, HTR3A
16dihydroergotamine29 45 1112.9HTR1B, HTR2A, HTR1D, HTR3A
17zotepine45 2911.9HTR1B, HTR3A, HTR2A, HTR1D
18methiothepin45 2911.9HTR1D, HTR2A, HTR3A, HTR1B
19ritanserin29 4511.9HTR3A, HTR2A, HTR1D, HTR1B
20metergoline45 2911.9HTR1D, HTR2A, HTR3A, HTR1B
21tetrodotoxin45 60 2912.9EDNRA, VIP, CALCA, HTR3A, NPY
22olanzapine50 45 29 11 2414.9GNB3, HTR1D, HTR2A, HTR1B, HTR3A
23methysergide45 29 1112.9HTR1B, HTR1D, HTR3A, HTR2A
24atropine45 29 1112.9PNOC, NPY, CALCA, EDNRA
25tryptamine45 29 2412.9HTR2A, HTR3A, HTR1B, HTR1D
26capsaicin45 2911.9NPY, PNOC, S100A12, VIP, CALCA
27fenfluramine29 45 1112.8HTR3A, HTR1B, NPY, HTR2A
28propranolol45 29 50 11 2414.8HTR1D, VIP, HTR3A, HTR1B, CALCA
29ergotamine29 45 1112.8HTR1D, HTR2A, HTR3A, HTR1B
30ketanserin29 4511.8HTR3A, HTR1D, HTR1B, HTR2A
31triptan4510.8HTR3A, CALCA, HTR1B
32(tfmpp)4510.8HTR3A, HTR2A, HTR1B
33calcium45 50 11 2413.8PNOC, VIP, CALCA, ANXA3, EDNRA, HTR2A
34clozapine45 29 50 1113.8HTR2A, HTR1D, GNB3, HTR1B, HTR3A
35aripiprazole29 50 45 11 2414.8HTR3A, HTR1B, HTR1D, HTR2A
36cgs-120662910.8HTR1D, HTR2A, HTR1B
37gr 1279354510.8HTR3A, HTR1D, HTR2A
38frovatriptan45 1111.7HTR1D, HTR3A, HTR1B
39sb 2242892910.7HTR1D, HTR1B, HTR2A
40pipamperone29 4511.7HTR1D, HTR2A, HTR1B
411-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane4510.7HTR1B, HTR3A, HTR2A
42phosphoramidon45 1111.7VIP, NPY, EDNRA, CALCA
43ziprasidone50 29 45 1113.7HTR1D, HTR3A, HTR1B, HTR2A
44paroxetine45 50 29 1113.6HTR1B, HTR3A, HTR2A, PF4
45sb 2166412910.6HTR1D, HTR2A, HTR1B
46s330842910.5HTR1B, HTR1D, HTR2A
47indomethacin45 60 29 1113.5NPY, VIP, CALCA, EDNRA, AKR1A1, PF4
489-oh-risperidone2910.5HTR1B, HTR2A, HTR1D
49epinephrine45 11 2412.4VIP, NPY, PF4, CALCA, GNB3, HP
50helospectin4510.2CALCA, VIP, NPY

GO Terms for genes affiliated with Headache

Sources:
16Gene Ontology
See all sources

Cellular components related to Headache according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.5HCRTR2, HTR1B, HTR3A, HTR2A, EDNRA, HTR1D
2extracellular regionGO:00557610.5ADH7, VIP, CALCA, S100A12, NPY, HP
3neuronal cell bodyGO:04302510.4CALCA, CACNA1A, HTR3A, VIP
4plasma membraneGO:00588610.2HTR2A, HCRTR2, ANXA3, EDNRA, HTR1B, CACNA1A

Biological processes related to Headache according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:00821710.8CALCA, GNB3, NPY, EDNRA
2synaptic transmissionGO:00726810.8PNOC, CACNA1A, GNB3, HTR1B, HTR3A, HTR2A
3regulation of behaviorGO:05079510.8HTR1D, HTR2A, HTR1B
4vasoconstrictionGO:04231010.8EDNRA, HTR1D, HTR1B
5neuropeptide signaling pathwayGO:00721810.8CALCA, NPY, HCRTR2, PNOC
6feeding behaviorGO:00763110.8HCRTR2, NPY, CALCA
7G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.7NPY, HTR1D, HTR1B
8negative regulation of synaptic transmission, glutamatergicGO:05196710.7HTR1B, HTR2A
9positive regulation of macrophage differentiationGO:04565110.7CALCA, PF4
10negative regulation of cAMP biosynthetic processGO:03081810.7HTR1B, EDNRA
11regulation of dopamine secretionGO:01405910.7HTR1B, HTR2A
12serotonin receptor signaling pathwayGO:00721010.7HTR3A, HTR2A
13negative regulation of potassium ion transportGO:04326710.7VIP, HTR2A
14cellular aldehyde metabolic processGO:00608110.6AKR1A1, ADH4
15ethanol oxidationGO:00606910.6ADH4, ADH7
16G-protein coupled receptor internalizationGO:00203110.6CALCA, HTR1B
17agingGO:00756810.5EDNRA, HTR2A, CALCA
18defense response to bacteriumGO:04274210.5HP, ANXA3, S100A12
19elevation of cytosolic calcium ion concentrationGO:00720410.4CALCA, CACNA1A, EDNRA
20elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.2EDNRA, CALCA

Molecular functions related to Headache according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1serotonin bindingGO:05137810.7HTR1D, HTR2A, HTR3A, HTR1B
2serotonin receptor activityGO:00499310.6HTR1D, HTR2A, HTR3A, HTR1B
3neuropeptide hormone activityGO:00518410.6VIP, NPY, PNOC
4alcohol dehydrogenase activity, zinc-dependentGO:00402410.5ADH7, ADH4
5retinol dehydrogenase activityGO:00474510.5ADH7, ADH4
6alditol:NADP+ 1-oxidoreductase activityGO:00403210.5ADH4, AKR1A1
7alcohol dehydrogenase (NAD) activityGO:00402210.4ADH4, ADH7
8retinol bindingGO:01984110.2ADH7, ADH4

Products for genes affiliated with Headache

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  • Proteins
  • Lysates
  • Antibodies

Sources for Headache

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet