Aliases & Classifications for Headache

Summaries for Headache

NINDS : 50 Headache is our most common form of pain and a major reason cited for days missed at work or school as well as visits to the doctor.  The International Classification of Headache Disorders, published by the International Headache Society, is used to classify more than 150 types of primary and secondary headache disorders. Primary headaches occur independently and are not caused by another medical condition.  Migraine, cluster, and tension-type headache are the more familiar types of primary headache. Secondary headaches are symptoms of another health disorder that causes pain-sensitive nerve endings to be pressed on or pulled or pushed out of place. They may result from underlying conditions including fever, infection, medication overuse, stress or emotional conflict, high blood pressure, psychiatric disorders, head injury or trauma, stroke, tumors, and nerve disorders (particularly trigeminal neuralgia, a chronic pain condition that typically affects a major nerve on one side of the jaw or cheek). Headaches can range in frequency and severity of pain. Some individuals may experience headaches once or twice a year, while others may experience headaches more than 15 days a month. Pain can range from mild to disabling and may be accompanied by symptoms such as nausea or increased sensitivity to noise or light, depending on the type of headache.

MalaCards based summary : Headache is related to cluster headache and familial hemiplegic migraine. An important gene associated with Headache is NPC1 (NPC Intracellular Cholesterol Transporter 1), and among its related pathways/superpathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Dasatinib Pathway, Pharmacokinetics. The drugs Dopamine and Nitric Oxide have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and pituitary, and related phenotypes are behavior/neurological and cardiovascular system

MedlinePlus : 40 Almost everyone has had a headache. Headache is the most common form of pain. It's a major reason people miss days at work or school or visit the doctor. The most common type of headache is a tension headache. Tension headaches are due to tight muscles in your shoulders, neck, scalp and jaw. They are often related to stress, depression or anxiety. You are more likely to get tension headaches if you work too much, don't get enough sleep, miss meals, or use alcohol. Other common types of headaches include migraines, cluster headaches, and sinus headaches. Most people can feel much better by making lifestyle changes, learning ways to relax and taking pain relievers. Not all headaches require a doctor's attention. But sometimes headaches warn of a more serious disorder. Let your health care provider know if you have sudden, severe headaches. Get medical help right away if you have a headache after a blow to your head, or if you have a headache along with a stiff neck, fever, confusion, loss of consciousness, or pain in the eye or ear. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 72 Headache is the symptom of pain anywhere in the region of the head or neck. It occurs in migraines... more...

Related Diseases for Headache

Diseases related to Headache via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 761)
# Related Disease Score Top Affiliating Genes
1 cluster headache 34.2 CACNA1A CALCA
2 familial hemiplegic migraine 32.0 ATP1A2 CACNA1A CALCA SCN1A
3 sporadic hemiplegic migraine 31.7 ATP1A2 CACNA1A SCN1A
4 migraine without aura 31.6 ATP1A2 CACNA1A KCNK18 SCN1A
5 hemiplegic migraine 31.4 ATP1A2 CACNA1A CALCA SCN1A
6 migraine with aura 31.3 ATP1A2 CACNA1A EDNRA KCNK18 SCN1A
7 migraine with or without aura 1 30.8 ATP1A2 CACNA1A CALCA EDNRA KCNK18 SCN1A
8 complex regional pain syndrome 29.0 CALCA TAC1 TNF
9 hemiplegia 28.9 ATP1A2 CACNA1A CALCA SCN1A TAC1
10 asthma 27.8 CALCA CYP1A2 HLA-DQB1 TAC1 TNF
11 hypnic headache 12.4
12 sunct headache 12.3
13 headache associated with sexual activity 12.3
14 new daily-persistent headache 12.3
15 thunderclap headache 12.2
16 exertional headache 12.1
17 cough headache 12.1
18 cluster headache, familial 12.1
19 hyperthermia, cutaneous, with headaches and nausea 11.9
20 handl syndrome 11.6
21 hemicrania continua 11.6
22 paroxysmal hemicrania 11.4
23 lyme disease 11.1
24 temporal arteritis 11.1
25 meningitis 11.1
26 traumatic brain injury 11.1
27 reversible cerebral vasoconstriction syndrome 11.1
28 hydrocephalus 11.1
29 encephalitis 11.1
30 influenza 11.1
31 intracranial hypertension, idiopathic 11.0
32 head injury 11.0
33 intracranial aneurysm 11.0
34 syringomyelia 11.0
35 aneurysm 11.0
36 mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes 11.0
37 arachnoid cysts 11.0
38 chiari malformation 11.0
39 systemic lupus erythematosus 11.0
40 brain injury 11.0
41 cerebral aneurysms 11.0
42 sturge-weber syndrome 10.9
43 pituitary tumors 10.9
44 cyclic vomiting syndrome 10.9
45 cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 1 10.9
46 stroke, ischemic 10.9
47 arteriovenous malformation 10.9
48 chiari malformation type i 10.9
49 episodic ataxia 10.9
50 pheochromocytoma 10.9

Graphical network of the top 20 diseases related to Headache:



Diseases related to Headache

Symptoms & Phenotypes for Headache

MGI Mouse Phenotypes related to Headache:

43 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.37 ABCB1 ATP1A2 CACNA1A CCK CYP1A2 EDNRA
2 cardiovascular system MP:0005385 10.33 CYP1A2 EDNRA HLA-DQB1 IDO1 MSX2 NPC1
3 homeostasis/metabolism MP:0005376 10.25 ABCB1 ATP1A2 CACNA1A CCK CYP1A2 EDNRA
4 endocrine/exocrine gland MP:0005379 10.24 NPC1 PTGS2 TNF ABCB1 CACNA1A CCK
5 hematopoietic system MP:0005397 10.18 ABCB1 CACNA1A EDNRA HLA-DQB1 IDO1 MSX2
6 mortality/aging MP:0010768 10.17 ATP1A2 CACNA1A CYP1A2 EDNRA HLA-DQB1 MSX2
7 immune system MP:0005387 10.15 EDNRA HLA-DQB1 IDO1 MSX2 NPC1 PTGS2
8 nervous system MP:0003631 10.15 ABCB1 ATP1A2 CACNA1A CCK EDNRA HLA-DQB1
9 integument MP:0010771 10.02 ATP1A2 CACNA1A EDNRA MSX2 PTGS2 TAC1
10 muscle MP:0005369 10.01 ATP1A2 CACNA1A EDNRA HLA-DQB1 IDO1 MSX2
11 liver/biliary system MP:0005370 9.93 ABCB1 CYP1A2 HLA-DQB1 NPC1 PTGS2 TNF
12 normal MP:0002873 9.91 ATP1A2 CACNA1A EDNRA HLA-DQB1 MSX2 NPC1
13 no phenotypic analysis MP:0003012 9.87 ABCB1 CACNA1A CCK CYP1A2 NPC1 PTGS2
14 renal/urinary system MP:0005367 9.63 CCK EDNRA HLA-DQB1 IDO1 PTGS2 TAC1
15 reproductive system MP:0005389 9.61 ABCB1 CACNA1A HLA-DQB1 IDO1 KCNK18 NPC1
16 respiratory system MP:0005388 9.23 ATP1A2 CACNA1A CYP1A2 EDNRA HLA-DQB1 NPC1

Drugs & Therapeutics for Headache

Drugs for Headache (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 853)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-61-6, 62-31-7 681
2
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1 10102-43-9 145068
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-02-2 5743
4
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 50-78-2 2244
5
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 50-28-2 5757
6
Curcumin Approved, Investigational Phase 4 458-37-7 969516
7
Midazolam Approved, Illicit Phase 4,Phase 2 59467-70-8 4192
8
Iron Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 7439-89-6 23925
9
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
10
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
11
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1 103-90-2 1983
12
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
13
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Phase 1 15687-27-1 3672
14
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 99-66-1 3121
15
Clopidogrel Approved Phase 4,Phase 3,Phase 2 120202-66-6, 113665-84-2 60606
16
Nitroglycerin Approved, Investigational Phase 4,Phase 3,Phase 1 55-63-0 4510
17
Galantamine Approved Phase 4,Phase 2 357-70-0 9651
18
Acetylcholine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 51-84-3 187
19
Succinylcholine Approved Phase 4 306-40-1 5314
20
Metoclopramide Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 364-62-5 4168
21
Octreotide Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 83150-76-9 6400441 383414
22
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-45-6, 75614-87-8 774
23
Propranolol Approved, Investigational Phase 4,Phase 3,Phase 2 525-66-6 4946
24
Ticlopidine Approved Phase 4 55142-85-3 5472
25
Sumatriptan Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 103628-46-2 5358
26
Betamethasone Approved, Vet_approved Phase 4,Phase 2,Phase 1 378-44-9 9782
27
Topiramate Approved Phase 4,Phase 3,Phase 2,Phase 1 97240-79-4 5284627
28
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2 76631-46-4, 113775-47-6 5311068 56032 68602
29
Ephedrine Approved Phase 4,Phase 3,Phase 1 299-42-3 9294
30
Naproxen Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 22204-53-1 156391 1302
31
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 137-58-6 3676
32
Zonisamide Approved, Investigational Phase 4,Phase 3,Phase 2 68291-97-4 5734
33
Flurbiprofen Approved, Investigational Phase 4 5104-49-4 3394
34
Acetazolamide Approved, Vet_approved Phase 4,Phase 2,Phase 3 59-66-5 1986
35
Amitriptyline Approved Phase 4,Phase 3,Phase 2,Phase 1 50-48-6 2160
36
Ketamine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 6740-88-1 3821
37
Ketorolac Approved Phase 4,Phase 3,Phase 2,Phase 1 74103-06-3, 66635-83-4 3826
38
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 26787-78-0 33613 2171
39
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 2078-54-8 4943
40
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
41
Acitretin Approved Phase 4 55079-83-9 5284513 6437841
42
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
43
Milnacipran Approved, Investigational Phase 4 92623-85-3 65833
44
Perphenazine Approved Phase 4,Phase 3,Phase 2,Phase 1 58-39-9 4748
45
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
46
Almotriptan Approved, Investigational Phase 4,Phase 3 154323-57-6, 181183-52-8 123606
47
Aprepitant Approved, Investigational Phase 4,Phase 1,Phase 2 170729-80-3 6918365 151165
48
Pentazocine Approved, Vet_approved Phase 4 359-83-1 441278
49
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2 1994-09-7, 94-09-7 2337
50
Pseudoephedrine Approved Phase 4,Phase 3,Phase 1 90-82-4 7028

Interventional clinical trials:

(show top 50) (show all 1729)

# Name Status NCT ID Phase Drugs
1 Sumatriptan 4 mg Statdose in the Acute Treatment of Cluster Headache Unknown status NCT00399243 Phase 4 Sumatriptan 4mg Statdose injection
2 Randomized Placebo Controlled Trial With Etoricoxib That is Taken to Prevent the Yom Kippur Headache Unknown status NCT00752921 Phase 4 etoricoxib;placebo
3 Detoxification and Treatment of Subjects With Medication Overuse Headache Unknown status NCT00432549 Phase 4 Almotriptan;Topiramate
4 Galantamine in the Treatment of Post-Traumatic Headache Unknown status NCT00219869 Phase 4 Galantamine
5 Self-control Trial to Evaluate the Role of Aprepitant in the Prophylaxis of Post-lumbar-punture-headache (PLPH) Unknown status NCT02347878 Phase 4 Aprepitant
6 IM Ketorolac vs Cambia for the Acute Treatment of Severe Migraine Unknown status NCT02664116 Phase 4 Diclofenac postassium powder for oral solution and placebo injection;Ketorolac intramuscular injection and placebo oral solution
7 Preventive Treatment of Episodic and Chronic Migraine Unknown status NCT01319825 Phase 4 milnacipran
8 Clopidogrel For the Prevention of New Onset Migraine Headache Following Transcatheter Closure of Atrial Septal Defects Unknown status NCT00799045 Phase 4 Clopidogrel
9 Effects on the Diagnostic Accuracy of Magnetic Imaging Angiographies of the Supra-Aortic Vessels by Three Different Magnetic Resonance Contrast Agents in Patients Unknown status NCT00132223 Phase 4 Contrast agent
10 The Combined Effects of omega3 Fatty Acids and Curcumin Supplementation on Inflammatory and Endothelial Factors in Migraine Patients Unknown status NCT02532023 Phase 4
11 A Randomized Trial of Valproate Versus Ketorolac Versus Metoclopramide for Acute Migraine Unknown status NCT01267864 Phase 4 Metoclorpamide;Ketorolac;Valproate
12 Prevention of Menstrual Migraines: Effects of Estrogen Add-back During the HFI in Patients Using Continuous Oral Contraceptives. Unknown status NCT01251263 Phase 4 Estradiol or Placebo;Estradiol or Placebo
13 American Migraine Prevention Study Unknown status NCT00363506 Phase 4
14 Strategy to Improve Adherence of Roflumilast Unknown status NCT02018432 Phase 4 Roflumilast escalation dosage;Roflumilast conventional dosage
15 Gastrodin Prevents Cognitive Decline Related to Cardiopulmonary Bypass Unknown status NCT00297245 Phase 4 cognitive function
16 Comparison of Three Kinds of Postoperative Analgesia After Total Knee Arthroplasty Unknown status NCT02094339 Phase 4 ropivacaine;ropivacaine;opioid
17 Evaluation of the Efficacy in Decreasing Iron Absorption in Patients With Congenital Dyserythropoietic Anemia Type I by Treatment With LOSEC Unknown status NCT01795794 Phase 4 omeprazole
18 Low-Dose (17.5 mg/Day) Acitretin: Comparable Efficacy Without the Side Effects? Unknown status NCT01228409 Phase 4 Acitretin 17.5 mg/day
19 Occipital Transcutaneous Stimulation in Chronic Migraine Unknown status NCT02307071 Phase 4
20 Study of the Safety and Efficacy of Botox in Bruxism Unknown status NCT00908050 Phase 4 Botulinum toxin type A
21 Middle Meatal Bacteriology During Acute Respiratory Infection in Children Unknown status NCT00545961 Phase 4 placebo;amoxicillin clavulanate acid
22 Effect of Subanesthetic Dose of Ketamine Combined With Propofol on Cognitive Function in Depressive Patients Undergoing Electroconvulsive Therapy Unknown status NCT02305394 Phase 4 ketamine and propofol;propofol and normal saline
23 Dexmedetomidine on Prevention of Side Effects of Hemabate Unknown status NCT02220361 Phase 4 placebo;low dose dexmedetomidine;high dose dexmedetomidine
24 Pain Relief In Irritable Bowel Syndrome Unknown status NCT02573844 Phase 4 Proklama
25 Effect of COX-2 Selective Inhibitors on Postoperative Insulin Resistance After Gastrointestinal Laparoscopic Surgery Unknown status NCT01930318 Phase 4 parecoxib
26 The CHECK Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine Completed NCT02657031 Phase 4 Prochlorperazine;Ketamine;Diphenhydramine;Ondansetron;Normal Saline
27 Effect of Osteopathic Manipulative Treatment for Patients With Chronic Headache Completed NCT01332864 Phase 4
28 A Research Study to Examine Cutaneous Allodynia and Cluster Headache Completed NCT00329836 Phase 4
29 Efficacy of Euminz® for Tension-Type Headache Completed NCT01770080 Phase 4 Euminz®;Placebo
30 Metoclopramide Versus Ketorolac for Tension-type Headache Completed NCT01011673 Phase 4 Metoclopramide;Ketorolac
31 Trial of Etoricoxib (Arcoxia) Taken Prophylactically to Prevent Ramadan Headache Completed NCT01148303 Phase 4 Etoricoxib;Etoricoxib;Placebo
32 Diclofenac Administered Before Skull Operations Reduces the Severity of Headache After the Intervention Completed NCT01907984 Phase 4 Diclofenac;Midazolam
33 Placebo and Active Controlled, Double Dummy Study to Compare Efficacy of Aspirin and Ibuprofen in Treatment of Episodic Tension-type Headache Completed NCT01464983 Phase 4 Acetylsalicylic acid (Aspirin, BAYE4465);Acetylsalicylic acid (Aspirin, BAYE4465);Ibuprofen;Ibuprofen;Placebo
34 Zomig - Treatment of Acute Migraine Headache in Adolescents Completed NCT01211145 Phase 4 Placebo;Zolmitriptan;Zolmitriptan;Zolmitriptan
35 Comparative Study Between Hydrocortisone and Mannitol in Treatment of Postdural Puncture Headache Completed NCT02760862 Phase 4 hydrocortisone 100mg.;mannitol 20% intravenous fluid
36 Cosyntropin Versus Epidural Blood Patch (EBP) for Treatment of Treatment of Post Dural Puncture Headache Completed NCT02394457 Phase 4 Cosyntropin
37 A Study Comparing the Effectiveness and Safety of ULTRACET® (Tramadol HCl/Acetaminophen) Versus Placebo for the Treatment of Acute Pain From a Migraine Headache Completed NCT00297375 Phase 4 tramadol HCl/acetaminophen
38 Comparing Naproxen to Sumatriptan for Emergency Headache Patients Completed NCT00449787 Phase 4 Sumatriptan 100 mg;Naproxen
39 IV Haloperidol for the Treatment of Headache in the ED Completed NCT02747511 Phase 4 Haloperidol;Placebo
40 Study on Migraine and Headache in Epileptic Patients Completed NCT00642564 Phase 4
41 An Open Trial of Duloxetine on Comorbid Major Depression and Chronic Headache Completed NCT00531895 Phase 4 duloxetine
42 Evaluation of the Effectiveness of Topiramate in Preventing the Transformation From Episodic Migraine to Chronic Daily Headache. Completed NCT00212810 Phase 4 Topiramate
43 Haldol/Diphenhydramine Versus Metoclopramide/Diphenhydramine for Treatment of Acute Headache in the Emergency Department: A Randomized Controlled Trial Completed NCT02098499 Phase 4 Haloperidol;Metoclopramide 10mg;Diphenhydramine
44 Effectiveness And Safety Of Frovatriptan For The Management (Acute Treatment) Of Menstrual Migraine Completed NCT00904098 Phase 4 Frovatriptan;Usual Care
45 Intravenous Dexketoprofen and Paracetamol in the Treatment of Headache Caused by Acute Migraine Attack Completed NCT01730326 Phase 4 Paracetamol;Dexketoprofen
46 Oral Dexamethasone for Treatment of Migraine Completed NCT00216736 Phase 4 Dexamethasone;placebo
47 Effect of Vitamin D Supplementation on Muscular Strength, Musculoskeletal Pain and Headache Completed NCT01263288 Phase 4
48 A Study of the Effectiveness and Safety of Almotriptan Versus Placebo in the Treatment of Migraine Headache Completed NCT00210509 Phase 4 almotriptan malate
49 Cupping and Serkangabin Versus Conventional Migraine Treatment Completed NCT01476930 Phase 4 conventional migraine drug treatment
50 Rizatriptan in Acute Treatment of Migraine in Patients With Unilateral Trigeminal-autonomic Symptoms. Completed NCT00753311 Phase 4 rizatriptan or placebo

Search NIH Clinical Center for Headache

Genetic Tests for Headache

Genetic tests related to Headache:

# Genetic test Affiliating Genes
1 Headache 28

Anatomical Context for Headache

MalaCards organs/tissues related to Headache:

38
Brain, Testes, Pituitary, Eye, Spinal Cord, Lung, Cortex

Publications for Headache

Articles related to Headache:

(show top 50) (show all 2454)
# Title Authors Year
1
Genetic association of HCRTR2, ADH4 and CLOCK genes with cluster headache: a Chinese population-based case-control study. ( 29318394 )
2018
2
Headache and Alexithymia in Children and Adolescents: What Is the Connection? ( 29449820 )
2018
3
Characteristics of headache in relation to the manifestation of Susac syndrome. ( 29449066 )
2018
4
A Hospital Based Retrospective Study of Acute Postpartum Headache. ( 29446070 )
2018
5
Headache in mitochondrial disorders. ( 29408771 )
2018
6
Cough Headache Presenting with Reversible Cerebral Vasoconstriction Syndrome: A Case Report. ( 29321411 )
2018
7
Testing of diagnosis criteria of tension-type headache: A multicenter clinical study. ( 29436849 )
2018
8
Frequency of Headache in Mitochondrial Disorders. ( 29411365 )
2018
9
New Onset Focal Stabbing Headache Associated With Peripheral Vertigo: A Case Report. ( 29034450 )
2018
10
A Child With Intermittent Headaches and Eosinophilic Meningitis. ( 29438532 )
2018
11
Understanding Spreading Depression from Headache to Sudden Unexpected Death. ( 29449828 )
2018
12
Characteristics of headache and its relationship with disease severity in patients with Crimean-Congo hemorrhagic fever. ( 29450871 )
2018
13
Late-Onset N-Acetylglutamate Synthase Deficiency: Report of a Paradigmatic Adult Case Presenting with Headaches and Review of the Literature. ( 29364180 )
2018
14
The headache under-response to treatment (HURT) questionnaire, an outcome measure to guide follow-up in primary care: development, psychometric evaluation and assessment of utility. ( 29445880 )
2018
15
Central and peripheral processes in headache. ( 29438129 )
2018
16
Posttraumatic Headache. ( 29446796 )
2018
17
Neuroimaging utilization and findings in headache outpatients: Significance of red and yellow flags. ( 29433347 )
2018
18
Validation of the Ottawa Subarachnoid Hemorrhage Rule in patients with acute headache. ( 29440341 )
2018
19
Headache and Papilledema in Guillain-BarrAc Syndrome. ( 29374500 )
2018
20
Bilateral transnasal sphenopalatine block for treating postdural puncture headache. ( 29441179 )
2018
21
Spontaneous Intracranial Hypotension Induced Headaches and Onabotulinum Toxin A: A Case Report. ( 29103382 )
2018
22
Evaluation of Pain Syndromes, Headache, and Temporomandibular Joint Disorders in Children. ( 29153234 )
2018
23
Peripheral nerve blocks for the treatment of short-lasting unilateral neuralgiform headache with conjunctival injection and tearing (SUNCT) during pregnancy. ( 29450873 )
2018
24
Uncommon Pediatric Primary Headache Disorders. ( 29446797 )
2018
25
Diagnosis, pathophysiology, and management of cluster headache. ( 29174963 )
2018
26
Headache following head injury: a population-based longitudinal cohort study (HUNT). ( 29356960 )
2018
27
Case 2: Headache and Behavior Changes in an 11-year-old Boy. ( 29437129 )
2018
28
Frequency of Headache in Mitochondrial Disorders: A Response. ( 29411368 )
2018
29
Headache Linked to Intracranial Hypertension and Hypertrophic Pachymeningitis as the Initial and Dominant Presentation of Granulomatosis With Polyangiitis. Case Report and Review of the Recent Literature. ( 29446067 )
2018
30
Sphenopalatine ganglion stimulation for cluster headache, results from a large, open-label European registry. ( 29349561 )
2018
31
Sudden headache, lumbar puncture, and the diagnosis of subarachnoid hemorrhage in patients with a normal computed tomography scans. ( 29437311 )
2018
32
Societal burden of cluster headache in the United States: a descriptive economic analysis. ( 29125368 )
2018
33
Physicians Addicted to Prescribing Aspirin-a Disorder Of Cardiologists (PAPA-DOC) Syndrome: The Headache of Nonevidence-Based Medicine for Ischemic Heart Disease? ( 29413373 )
2018
34
Systematic review of the safety and effectiveness of peripheral neurostimulation of the sphenopalatine ganglion for the treatment of refractory chronic cluster headache. ( 29338934 )
2018
35
Extracranial Four-Vessel Dissection with Reversible Cerebral Vasoconstriction Syndrome in a Habitual Cocaine User Presenting with Thunderclap Headache. ( 29163751 )
2017
36
A Case of Prethoracic Pain Radiating Upward and Initiating Nervus Intermedius Neuralgia and Migraine Headache: Could Epicrania Fugax Pain Start in the Upper Body? ( 28931106 )
2017
37
Surgical "Fat Patch" Improves Secondary Intracranial Hypotension Orthostatic Headache Associated with Lumbosacral Dural Ectasia. ( 28866058 )
2017
38
Clinical Characteristics and Treatment Patterns Among Patients Diagnosed With Cluster Headache in U.S. Healthcare Claims Data. ( 28581025 )
2017
39
Sudden onset headache in a 50 year old woman. ( 28935630 )
2017
40
Children with migraine: Provocation of headache via pressure to myofascial trigger points in the trapezius muscle? - A prospective controlled observational study. ( 28952174 )
2017
41
Ketamine Infusion Combined With Magnesium as a Therapy for Intractable Chronic Cluster Headache: Report of Two Cases. ( 28670718 )
2017
42
Environmental Toxin Acrolein Alters Levels of Endogenous Lipids, Including TRP Agonists: A Potential Mechanism for Headache Driven by TRPA1 Activation. ( 29430557 )
2017
43
A case report of cough headache with transient elevation of intracranial pressure and bilateral internal jugular vein valve incompetence: A primary or secondary headache? ( 28376658 )
2017
44
Economics of Inhaled Oxygen Use as an Acute Therapy for Cluster Headache in the United States of America. ( 28842974 )
2017
45
Reversible cerebral vasoconstriction syndrome: an important and common cause of thunderclap and recurrent headaches. ( 29274685 )
2017
46
Patent Foramen Ovale and Migraine Headache. ( 28886844 )
2017
47
Remission of chronic headache: Rates, potential predictors and the role of medication, follow-up results of the German Headache Consortium (GHC) Study. ( 28944686 )
2017
48
Prevalence, characteristics and management of headache experienced by people with schizophrenia and schizoaffective disorder: a cross sectional cohort study. ( 28747114 )
2017
49
Headache, Chiari malformation type 1 and treatment options. ( 28082322 )
2017
50
Oxygen for Cluster Headache. ( 28967120 )
2017

Variations for Headache

ClinVar genetic disease variations for Headache:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 NPC1 NM_000271.4(NPC1): c.3019C> G (p.Pro1007Ala) single nucleotide variant Pathogenic rs80358257 GRCh37 Chromosome 18, 21118528: 21118528
2 NPC1 NM_000271.4(NPC1): c.1421C> T (p.Pro474Leu) single nucleotide variant Pathogenic rs372445155 GRCh38 Chromosome 18, 23554890: 23554890

Expression for Headache

Search GEO for disease gene expression data for Headache.

Pathways for Headache

GO Terms for Headache

Cellular components related to Headache according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.46 CALCA CCK SCN1A TAC1
2 neuronal cell body GO:0043025 9.02 CACNA1A CALCA CCK SCN1A TAC1
3 axon initial segment GO:0043194 8.96 CCK SCN1A

Biological processes related to Headache according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.83 CCK IDO1 PTGS2 TNF
2 response to drug GO:0042493 9.8 ABCB1 CYP1A2 NPC1 PTGS2
3 response to lipopolysaccharide GO:0032496 9.73 CYP1A2 IDO1 PTGS2 TAC1
4 inflammatory response GO:0006954 9.72 CALCA IDO1 PTGS2 TAC1 TNF
5 response to organic substance GO:0010033 9.63 CYP1A2 PTGS2 TNF
6 positive regulation of cytosolic calcium ion concentration GO:0007204 9.56 CACNA1A CALCA EDNRA TAC1
7 positive regulation of NF-kappaB import into nucleus GO:0042346 9.54 PTGS2 TNF
8 positive regulation of ossification GO:0045778 9.51 CALCA TAC1
9 cellular response to steroid hormone stimulus GO:0071383 9.48 ATP1A2 NPC1
10 negative regulation of smooth muscle contraction GO:0045986 9.4 CALCA PTGS2
11 positive regulation of fever generation GO:0031622 9.37 PTGS2 TNF
12 adult walking behavior GO:0007628 9.33 CACNA1A NPC1 SCN1A
13 response to pain GO:0048265 9.13 CACNA1A CALCA TAC1
14 regulation of blood pressure GO:0008217 9.02 ATP1A2 CALCA EDNRA PTGS2 TAC1

Molecular functions related to Headache according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 8.8 CYP1A2 IDO1 PTGS2

Sources for Headache

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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