Headache malady

MedlinePlus: Oh my aching head! nearly everyone has had a headache. the most common type of headache is a tension headache. tension headaches are due to tight muscles in your shoulders, neck, scalp and jaw. they are often related to stress, depression or anxiety. you are more likely to get tension headaches if you work too much, don't get enough sleep, miss meals or use alcohol. other common types of headaches include migraines, cluster headaches and sinus headaches. most people can feel much better by making lifestyle changes, learning ways to relax and taking pain relievers. headaches can have many causes, but serious causes of headaches are rare. sometimes headaches warn of a more serious disorder. let your health care provider know if you have sudden, severe headaches. get medical help right away if you have a headache after a blow to your head, or if you have a headache along with a stiff neck, fever, confusion, loss of consciousness or pain in the eye or ear. nih: national institute of neurological disorders and stroke²³

MalaCards: Headache is related to cluster headache and familial hemiplegic migraine. An important gene associated with Headache is EDNRA (endothelin receptor type A), and among its related pathways are IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. The compounds nitroglycerin and glucose have been mentioned in the context of this disorder. Affiliated tissues include brain, nk cells and t cells, and related mouse phenotypes are hematopoietic system and renal/urinary system.

NINDS: There are four types of headache:³¹

Wikipedia: A headache or cephalalgia is pain anywhere in the region of the head or neck. It can be a symptom of a...⁴⁴ more...

headache 31 23

Diseases related to headache by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1122)

id	Related Disease	Score	Top Affiliating Genes
1	cluster headache	34.5	SELE, SERPINA1, VIP, VCAM1, CLOCK, MTHFR
2	familial hemiplegic migraine	30.6	SCN1A, ATP1A2, CACNA1A
3	thrombotic thrombocytopenic purpura, acquired	28.4	SELE, APOH, HP, PPBP
4	migraine with aura	28.0	VIP, KCNK18, SCN1A, MTHFR, ATP1A2, F5
5	spotted fever	27.6	IFNG, IDO1, TNF, PTGS2, NOS2
6	poliomyelitis	27.5	CD40LG, IL4, IFNG, ICAM1, TNF
7	listeriosis	27.5	IL6, IFNG, IDO1, TNF
8	leukostasis	27.3	SELE, VCAM1, ICAM1, TNF
9	herpes zoster	27.3	IL4, APOE, IFNG, HP, TNF, NOS2
10	nephropathia epidemica	27.1	IL1B, IL1RN, IL6, TNF
11	generalized anxiety disorder	27.1	MAOA, HTR1A, HTR2A, HTR2C, HTR3A, NPY
12	chronic pain	26.9	IL6, CALCA, PTGS2, PNOC, COMT, PDYN
13	migraine without aura	26.8	MTHFR, CACNA1A, TNF, NOS1, ACE, SLC6A3
14	mumps	26.8	CD40LG, IL1B, IL1RN, IL2RA, IL2RB, IL6
15	cadasil	26.6	SETD2, VIP, MTHFR, IL2RB, APOE, APOH
16	malaria	26.2	CD40LG, IL4, IFNG, TNF, NOS2
17	alzheimer's disease	26.0	APOE, APP, ACE, HFE
18	hemorrhagic fever with renal syndrome	26.0	VCAM1, CD40LG, INS, IL6, IGF1, IFNG
19	alcoholism	26.0	IL1RN, MAOA, HTR1A, HTR1B, HTR2A, HTR2C
20	toxoplasmosis	25.9	CD40LG, IL1B, IL4, IFNG, IDO1, GNAI1
21	functioning pituitary adenoma	25.9	IGF1, DRD2, SST, PRL, ADM
22	intracranial hypertension	25.9	ATP1A2, IL1B, APOH, F5, ALB, CACNA1A
23	normal pressure hydrocephalus	25.8	VIP, BDNF, APOE, ACE, TGFB1, NPY
24	antiphospholipid syndrome	25.8	SELE, VCAM1, MTHFR, CD40LG, APOH, IGF1
25	alpha 1-antitrypsin deficiency	25.6	SERPINA1, CCL2, IFNG, TNF, NOS1, NOS3
26	pituitary tumor	25.5	VIP, IL1RAPL2, IGF1, DRD2, SST, PRL
27	rubella	25.5	CD40LG, IL1B, IL1RN, IL2, IL2RA, IL2RB
28	brucellosis	25.5	SELE, CD40LG, IL1RN, IL2, IL4, IL6
29	hydrocephalus	25.4	VIP, BDNF, MTHFR, INS, APOE, APP
30	immunodeficiency	25.3	VIP, S100A12, CD40LG, INS, IL2, IL2RA
31	arthritis	25.3	SERPINA1, VIP, IL1B, IL6, TNF
32	rabies	25.1	SETD2, VIP, IL1B, IL4, APP, IFNG
33	multiple sclerosis	25.0	IL1B, IL1RN, IL2RA, APOE, IFNG, ICAM1
34	whiplash	24.9	IL6, IFNG, KNG1
35	toxic shock syndrome	24.9	CD40LG, IL1B, IL1RN, IL2, IL4, IL6
36	gastroenteritis	24.7	SCN1A, IL1B, IL1RN, IL2, IL6, ALB
37	human immunodeficiency virus infectious disease	24.6	CD40LG, INS, IL1B, IL2, IL2RA, IL4
38	arteriovenous malformation	24.6	IL1B, IL6, APOE, ALB, TNF, SLC2A1
39	hypopituitarism	24.6	INS, IL6, IGF1, SST, PRL, SOD1
40	back pain	24.5	INS, IL1B, IL1RN, IL6, CALCA, TNF
41	gigantism	24.4	INS, IL6, IGF1, F5, ALB, SST
42	pituitary adenoma	24.4	VIP, INS, IL1RN, IL2, IL6, IGF1
43	dengue shock syndrome	24.3	IL1B, IL1RAPL2, IL1RN, IL6, CCL2, TNF
44	west nile virus	24.3	SCN1A, CD40LG, IL1B, IL6, IFNG, ALB
45	influenza	24.3	CD40LG, IL1B, IL1RN, IL2, IL2RA, IL2RB
46	systemic lupus erythematosus	24.2	SELE, VIP, VCAM1, BDNF, CD40LG, IL1RAPL2
47	hearing loss	24.2	SETD2, BDNF, MTHFR, APOE, APOH, F5
48	tonsillitis	24.2	BDNF, S100A12, CD40LG, IL2, IL2RA, IL4
49	toxic encephalopathy	24.0	BDNF, IL1B, IL6, APP, MAOA, TNF
50	severe acute respiratory syndrome	23.9	IL1B, IL2, IL4, IL6, CCL2, IFNB1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to headache:

²²

MGI Mouse Phenotypes related to headache:

²⁵ (show all 25)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.0	PDCD10, UNC93B1, MSX2, CCM2, IDO1, CACNA1A
2	renal/urinary system phenotype	MP:0005367	9.7	UNC93B1, INS, APOE, HTR3A, AKR1A1, DRD2
3	endocrine/exocrine gland phenotype	MP:0005379	9.6	IFNG, IL2RB, IL2, CD40LG, MSX2, HTR1B
4	respiratory system phenotype	MP:0005388	9.4	ADORA1, PSEN1, HCRT, CACNA1A, ELN, NOS1
5	embryogenesis phenotype	MP:0005380	9.3	SETD2, MSX2, ATP1A2, PDCD10, HTR2B, ADCYAP1
6	other phenotype	MP:0005395	9.2	PSEN1, NOS3, NOS2, NOS1, PTGS2, APP
7	no phenotypic analysis	MP:0003012	8.7	BDNF, CLOCK, VCAM1, IFNB1, MTHFR, INS
8	liver/biliary system phenotype	MP:0005370	8.6	CLOCK, UNC93B1, INS, IL2, IL6, IFNG
9	skeleton phenotype	MP:0005390	8.3	POLG, MSX2, INS, IL6, IGF1, IFNB1
10	digestive/alimentary phenotype	MP:0005381	8.0	IFNG, CLOCK, NPY, BDNF, MSX2, INS
11	immune system phenotype	MP:0005387	7.8	DRD2, NOS1, COMT, EDNRA, HFE, TLR3
12	integument phenotype	MP:0010771	7.4	PDCD10, CLOCK, BDNF, MSX2, ATP1A2, IL2RB
13	nervous system phenotype	MP:0003631	7.2	PDCD10, CLOCK, BDNF, KCNK18, SCN1A, MTHFR
14	reproductive system phenotype	MP:0005389	6.6	SLC6A3, ADCYAP1, ADIPOQ, IFNG, IDO1, HTR1B
15	growth/size phenotype	MP:0005378	6.6	HTR6, ADIPOQ, ADCYAP1, WFS1, CACNA1A, DRD2
16	normal phenotype	MP:0002873	6.6	EDNRA, EPO, ADORA1, SLC6A4, SLC6A3, NPY
17	adipose tissue phenotype	MP:0005375	6.5	NOS3, TNF, HTR2C, IGF1, CCL2, APOE
18	vision/eye phenotype	MP:0005391	6.5	CTNS, NOS1, CX3CR1, PSEN1, TGFB1, TTR
19	tumorigenesis	MP:0002006	5.4	DRD2, TNF, HP, ICAM1, PRL, IFNG
20	muscle phenotype	MP:0005369	5.0	IL6, APOE, APP, CCL2, CCM2, IGF1
21	mortality/aging	MP:0010768	4.6	SCN1A, HTR2C, HTR3A, HTR7, CACNA1A, HP
22	behavior/neurological phenotype	MP:0005386	4.2	PDCD10, SELE, VIP, CLOCK, BDNF, SCN1A
23	cellular phenotype	MP:0005384	3.4	TNF, CX3CR1, AKR1A1, HP, CACNA1A, HTR2B
24	homeostasis/metabolism phenotype	MP:0005376	2.8	SELE, BDNF, ADIPOQ, IGF1, IFNB1, IDO1
25	cardiovascular system phenotype	MP:0005385	2.7	ICAM1, HTR1A, HTR1B, HTR2B, CALCA, HP

Articles related to headache:

(show top 50)    (show all 147)

id	Title	Authors	Year	Affiliating Genes
1	Cluster headache is associated with the alcohol dehyd rogenase 4 (ADH4) gene. (19925625)	Rainero I.... Pinessi L.	2010	AKR1A1, ADH7, ADH4
2	Hemodialysis headache. (19203508)	Milinkovic M.... Stojimirovic B.	2009	ALB
3	Calcitonin gene-related peptide in blood: is it increased in the external jugular vein during migraine and cluster headache? A review. (19330286)	Tfelt-Hansen P.... Le H.	2009	CALCA
4	Effect of adrenomedullin on the cerebral circulation: relevance to primary headache disorders. (19126117)	Petersen K.A.... Olesen J.	2009	ADM
5	Cerebrospinal fluid cytokine levels in migraine, tension-type headache and cervicogenic headache. (19175774)	BA... White L.R.	2009	TGFB1, CCL2, IL1RN
6	Plasma calcitonin gene-related peptide concentration is comparable to control group among migraineurs and tension type headache subjects during inter-ictal period. (19277835)	Gupta R.... Bhatia M.	2009	CALCA
7	Drug consumption in medication overuse headache is in fluenced by brain-derived neurotrophic factor Val66Met polymorphism. (19517061)	Di Lorenzo C.... Pierelli F.	2009	BDNF
8	Common CX3CR1 Alleles Are Associated With a Reduced Risk of Headaches. (18194290)	Combadiere C.... Tzourio C.	2008	CX3CR1
9	The role of nitric oxide (NO) in migraine, tension-ty pe headache and cluster headache. (18789357)	Olesen J.	2008	NOS1
10	Serotonin transporter gene polymorphisms in patients with chronic tension-type headache: A preliminary study. (18688140)	Akcali A.... Pehlivan S.	2008	SLC6A4
11	Hypocretins and primary headaches: neurobiology and c linical implications. (18345971)	Rainero I.... Pinessi L.	2008	HCRT
12	Oligomerization state-dependent elevations of adiponectin in chronic daily headache. (18474846)	Peterlin B.L.... Reichenberger E.	2008	ADIPOQ
13	Increased plasma substance P and CGRP levels, and high ACE activity in migraineurs during headache-free periods. (17123735)	Fusayasu E.... Nakashima K.	2007	ACE, CALCA
14	Recurrent headache as the main symptom of acquired cerebral toxoplasmosis in nonhuman immunodeficiency virus-infected subjects with no lymphadenopathy: the parasite may be responsible for the neurogenic inflammation postulated as a cause of different types of headaches. (17303977)	Prandota J.	2007	IL4, IFNG, IDO1
15	G protein beta3 polymorphism and triptan response in cluster headache. (17361120)	Schurks M.... Rosskopf D.	2007	GNB3
16	Serotonin receptor ligands: treatments of acute migraine and cluster headache. (17087122)	Goadsby P.J.	2007	HTR3A
17	The headache-inducing effect of cilostazol in human volunteers. (17059437)	Birk S.... Olesen J.	2006	CALCA
18	The association between headache and Val158Met polymorphism in the catechol-O-methyltransferase gene: the HUNT Study. (16688411)	Hagen K.... Zwart J.A.	2006	COMT
19	Platelet membrane fluidity and peroxynitrite levels in migraine patients during headache-free periods. (15839850)	Taffi R.... Bartolini M.	2005	NOS3, NOS2
20	L-arginine supplementation enhances exhaled NO, breath condensate VEGF, and headache at 4,342 m. (16351563)	Mansoor J.K.... Schelegle E.S.	2005	EPO, SETD2
21	Patterns and predictors of prescription medication us e in the management of headache: findings from the 2000 Medical Expenditure Pan el Survey. (16178947)	Devine J.W.... Hadsall R.S.	2005	HTR3A
22	BIBN4096BS antagonizes human alpha-calcitonin gene related peptide-induced headache and extracerebral artery dilatation. (15735614)	Petersen K.A.... Olesen J.	2005	CALCA
23	Lack of association between the 3092 T-->C Clock gene polymorphism and cluster headache. (16232160)	Rainero I.... Pinessi L.	2005	CLOCK
24	New targets in the acute treatment of headache. (15891413)	Goadsby P.J.	2005	ADORA1, CALCA
25	Ehlers-Danlos syndrome: correlation with headache disorders in a young woman. (16388346)	Di Palma F.... Cronin A.H.	2005	ELN
26	Serotonin transporter polymorphism and harm avoidance personality in chronic tension-type headache. (15546263)	Park J.W.... Lee K.S.	2004	SLC6A4
27	A polymorphism of the hypocretin receptor 2 gene is associated with cluster headache. (15477554)	Rainero I.... Pinessi L.	2004	HCRTR2
28	The association between calcitonin gene-related peptide (CGRP), substance P and headache in pituitary tumours. (15761654)	Levy M.J.... Goadsby P.J.	2004	CALCA, TAC1
29	Blockade of CGRP receptors in the intracranial vasculature: a new target in the treatment of headache. (15265049)	Edvinsson L.	2004	CALCA
30	Tender points are not sites of ongoing inflammation - in vivo evidence in patients with chronic tension-type headache. (12603367)	Ashina M.... Olesen J.	2003	KNG1
31	New therapeutic target in primary headaches - blocking theCGRP receptor. (12783573)	Edvinsson L.	2003	CALCA
32	Migraine headache recurrence: relationship to clinical, pharmacological, and pharmacokinetic properties of triptans. (12656709)	GAcraud G.... Senard J.M.	2003	HTR1B
33	Induction of prolonged tenderness in patients with te nsion-type headache by means of a new experimental model of myofascial pain. (12752398)	MA... Jensen R.	2003	KNG1
34	Hypofunctionality of Gi proteins as aetiopathogenic mechanism for migraine and cluster headache. (11298662)	Galeotti N.... Bartolini A.	2001	GNAI1
35	Both neurogenic and vascular causes of primary headache (11680150)	Edvinsson L.	2001	VIP
36	Nefazodone for chronic daily headache prophylaxis: an open-label study. (11380644)	Saper J.R.... Tepper S.J.	2001	HTR2A
37	CACNA1A gene polymorphisms in cluster headache. (11843866)	Sjostrand C.... Hillert J.	2001	CACNA1A
38	Calcitonin gene-related peptide levels during nitric oxide-induced headache in patients with chronic tension-type headache. (11284996)	Ashina M.... Olesen J.	2001	CALCA
39	The dominant role of increased intrasellar pressure in the pathogenesis of hypopituitarism, hyperprolactinemia, and headaches in patients with pituitary adenomas. (10843153)	Arafah B.M.... Selman W.R.	2000	PRL
40	Genetics of primary headaches. (10499169)	Kors E.E.... Ferrari M.D.	1999	CACNA1A
41	beta-Thromboglobulin and 11-dehydrothromboxane B in tension-type headache. (15613179)	Oishi M.... Mochizuki Y.	1998	PF4
42	Antinuclear and anticardiolipin antibodies in primary headache syndromes (12799962)	Straube A.... Wick M.	1998	APOH
43	Headache in systemic lupus erythematosus: a controlle d study. (9566671)	Sfikakis P.P.... Moutsopoulos H.M.	1998	APOH
44	Sumatriptan. A reappraisal of its pharmacology and therapeutic efficacy in the acute treatment of migraine and cluster headache. (7516861)	Plosker G.L.... McTavish D.	1994	HTR1D
45	Effect of sulpiride or paroxetine on cerebrospinal fluid neuropeptide concentrations in patients with chronic tension-type headache. (7991067)	Bach F.W.... Olesen J.	1994	PDYN
46	Platelet superoxide dismutase in migraine and tension-type headache. (7954742)	Shimomura T.... Takahashi K.	1994	SOD1
47	Changes in neutrophil met-enkephalin containing peptides in episodic cluster headache. (1889984)	Figuerola M.L.... Leston J.A.	1991	CPA6
48	Analgesic effect on headaches of octreotide, a somatostatin analogue, in a case of non-functioning pituitary adenoma (1838161)	Turpin G.... de Gennes J.L.	1991	SST
49	Basic mechanisms in vascular headache. (2175382)	Moskowitz M.A.	1990	KNG1
50	Platelet function in tension headache (2141791)	Leira R.... Noya M.	1990	PF4

Genes related to headache according to GeneCards:

(show top 50)    (show all 102)

id	Symbol	Description	Score	GeneCards Section Context
1	EDNRA	endothelin receptor type A	11.0	Publications, Summaries
2	CALCA	calcitonin-related polypeptide alpha	11.0	Publications
3	HCRTR2	hypocretin (orexin) receptor 2	11.0	Publications
4	PNOC	prepronociceptin	11.0
5	VIP	vasoactive intestinal peptide	11.0	Publications
6	HTR3A	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	11.0	Publications
7	CACNA1A	calcium channel, voltage-dependent, P/Q type, alpha 1A subunit	11.0	Publications
8	HP	haptoglobin	11.0	Publications
9	ADH4	alcohol dehydrogenase 4 (class II), pi polypeptide	11.0	Publications
10	S100A12	S100 calcium binding protein A12	11.0	Publications
11	HTR1D	5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled	11.0	Publications
12	HTR1B	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled	11.0	Publications
13	ANXA3	annexin A3	11.0	Publications
14	ADH7	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	11.0	Publications
15	AKR1A1	aldo-keto reductase family 1, member A1 (aldehyde reductase)	11.0	Publications
16	CLOCK	clock homolog (mouse)	11.0	Publications
17	GNB3	guanine nucleotide binding protein (G protein), beta polypeptide 3	11.0	Publications
18	SERPINA1	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1	11.0	Publications
19	PF4	platelet factor 4	11.0	Publications
20	NPY	neuropeptide Y	11.0	Publications
21	GNAI1	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	11.0	Publications
22	IL2RB	interleukin 2 receptor, beta	11.0	Publications
23	MAOA	monoamine oxidase A	11.0	Publications
24	CPA6	carboxypeptidase A6	11.0	Publications
25	PRL	prolactin	11.0	Publications
26	HTR2A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	11.0	Publications
27	HFE	hemochromatosis	11.0	Publications
28	SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	11.0	Publications
29	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications
30	NOS1	nitric oxide synthase 1 (neuronal)	11.0	Publications
31	SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	11.0	Publications
32	ICAM1	intercellular adhesion molecule 1	11.0	Publications
33	VCAM1	vascular cell adhesion molecule 1	11.0	Publications
34	SELE	selectin E	11.0	Publications
35	NOS3	nitric oxide synthase 3 (endothelial cell)	11.0	Publications
36	CD40LG	CD40 ligand	11.0	Publications
37	NOS2	nitric oxide synthase 2, inducible	11.0	Publications
38	IL2RA	interleukin 2 receptor, alpha	11.0	Publications
39	INS	insulin	11.0	Publications
40	ALB	albumin	11.0	Publications
41	IL2	interleukin 2	11.0	Publications
42	TNF	tumor necrosis factor	11.0	Publications
43	KCNK18	potassium channel, subfamily K, member 18	11.0
44	UNC93B1	unc-93 homolog B1 (C. elegans)	11.0
45	MSX2	msh homeobox 2	11.0	Publications
46	CTNS	cystinosin, lysosomal cystine transporter	11.0
47	ABP1	amiloride binding protein 1 (amine oxidase (copper-containing))	11.0	Publications
48	HTR2B	5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled	11.0	Publications
49	TAC1	tachykinin, precursor 1	11.0	Publications
50	HTR6	5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled	11.0	Publications

Pathways related to headache according to GeneDecks:

(show top 50)    (show all 80)

id	Pathway	Score	Top Affiliating Genes
1	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.6	IL2, IL2RB, IL2RA
2	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics34	10.6	GNAI1, SLC6A4, MAOA, HTR1A, HTR1D, HTR2A
3	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q10	10.4	NPY, GNAI1, HCRT, HCRTR2, EDNRA, TACR1
4	IL-2 Signaling and its Primary Biological Effects in Different Immune Cell Types37	10.4	TNF, TGFB1, IL2RA, IL2RB, IL2
5	Doxorubicin Pathway, Pharmacokinetics34	10.2	NOS2, NOS3, NOS1, AKR1A1, SOD1
6	Calcium signaling pathway20	10.2	HTR2C, HTR2A, HTR2B, HTR6, HTR7, CACNA1A
7	Amine ligand-binding receptors38	10.0	HTR7, HTR6, HTR2C, HTR2B, HTR2A, HTR1D
8	NFAT Signaling and Lymphocyte Interactions36	10.0	CACNA1A, CCL2, IL4, IL2RB, IL2
9	Immune System38	10.0	S100A12, VCAM1, UNC93B1, IFNG, ICAM1
10	LDL Oxidation in Atherogenesis36	10.0	CCL2, TNF, ICAM1, VCAM1, IL1B
11	Jak-STAT signaling pathway20	9.9	IL2RB, IL4, IFNB1, PRL, EPO, IL2RA
12	Neuroactive ligand-receptor interaction20	9.8	DRD2, ADORA1, PRL, TACR1, HTR7, HTR6
13	PGC1Alpha Pathway36	9.7	IL1B, IL2, IL2RB, IL4
14	Akt Signaling36	9.6	PF4, IL2, IL2RA, IL2RB, CCL2, IL4
15	Molecular Mechanisms of Cancer36	9.6	CX3CR1, PSEN1, IL6, GNB3, PPBP, PF4
16	Endothelin-1 Signaling Pathway36	9.4	IL1B, IL2, IL4, IL6, GNAI1, NOS1
17	Immune response_MIF-mediated glucocorticoid regulation41	9.4	IL2, IL6, IFNG, ICAM1, TNF, PTGS2
18	Immune response MIF-mediated glucocorticoid regulation10	9.4	NOS2, PTGS2, TNF, ICAM1, IFNG, IL6
19	African trypanosomiasis20	9.1	ICAM1, IDO1, IFNG, IL1B, VCAM1, SELE
20	ERK Signaling36	9.0	TGFB1, PF4, PPBP, GNAI1, IL6, IL2
21	all-trans-Retinoic Acid Signaling in Brain36	8.9	PF4, PTGS2, IL2, IL1B, IL4, IL6
22	STAT3 Pathway36	8.9	IL2, IL2RB, IL2RA, IL4, IL6, TNF
23	Immune response_MIF in innate immunity response41	8.8	NOS2, PTGS2, TNF, IFNG, IL1B, IL6
24	Immune response MIF in innate immunity response10	8.8	IL1B, NOS2, IFNG, PTGS2, IL6, TNF
25	MIF Mediated Glucocorticoid Regulation36	8.7	TNF, IL1B, IL2, PF4, IL4, PTGS2
26	Cytokine Network36	8.7	IL1B, TNF, IFNG, IL2, IFNB1, IL6
27	Leishmaniasis20	8.7	PTGS2, IL4, IFNG, TNF, TGFB1, NOS2
28	MIF Regulation of Innate Immune Cells36	8.6	CCL2, IL4, IL2, IL1B, TNF, PTGS2
29	Malaria20	8.6	ICAM1, SELE, VCAM1, CD40LG, IL1B, IL6
30	Measles20	8.5	IL2, IL1B, IL2RA, IL2RB, TACR1, IFNG
31	p70S6K Signaling36	8.5	TGFB1, GNB3, GNAI1, IGF1, IL6, IL4
32	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	8.5	TLR3, IL4, IL1B, TGFB1, IFNG, IL6
33	Intracellular Calcium Signaling36	8.4	HTR3A, HTR6, TGFB1, GNAI1, GNB3, CACNA1A
34	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	8.1	TNF, IFNG, IGF1, APOE, IL6, IL1B
35	Rho Family GTPases36	8.1	IGF1, PPBP, IL1B, ELN, TGFB1, IL2
36	Transcription Role of VDR in regulation of genes involved in osteoporosis10	8.1	IL6, TNF, CALCA, IFNG, IL1B, APOE
37	Rheumatoid arthritis20	8.0	IFNG, ICAM1, CCL2, IL6, IL1B, TNF
38	Chagas disease (American trypanosomiasis)20	8.0	IL6, IFNG, TGFB1, ACE, NOS2, TNF
39	NF-KappaB (p50-p65) Pathway36	7.9	TLR3, PPBP, TNF, IGF1, IL6, IL1B
40	NF-KappaB Family Pathway36	7.9	IL1B, IL2, IL6, IGF1, TNF, PPBP
41	Renin-Angiotensin Pathway36	7.9	TGFB1, ACE, PPBP, PTGS2, IGF1, CCL2
42	TGF-Beta Pathway36	7.8	IL2RA, TGFB1, PPBP, IGF1, CCL2, IL6
43	MAPK Family Pathway36	7.8	IGF1, BDNF, TGFB1, PPBP, IL1B, IL2
44	PAK Pathway36	7.8	TGFB1, PF4, IL4, PPBP, TNF, IL2
45	Cytokine-cytokine receptor interaction20	7.7	IFNG, CD40LG, EPO, CX3CR1, PRL, TGFB1
46	p38 Signaling36	7.7	GNAI1, IL6, IL4, CCL2, GNB3, CX3CR1
47	DHA Signaling36	7.6	PPBP, IGF1, IL6, APP, IL2RA, IL2
48	Tec Kinases Signaling36	7.6	IL2, TGFB1, TLR3, PPBP, TNF, CX3CR1
49	Antioxidant Action of Vitamin-C36	7.6	CCL2, PF4, SLC2A1, IL4, CX3CR1, TGFB1
50	JAK-STAT Pathway36	6.8	PRL, PPBP, IFNG, IFNB1, IGF1, IL6

Compounds related to headache according to GeneDecks:

(show top 50)    (show all 557)

id	Compound	Score	Top Affiliating Genes
1	nitroglycerin32 9 9	12.6	GNB3, SST
2	glucose32	10.5	SETD2, S100A12, GNAI1, PDYN, SLC2A1, ADCYAP1
3	ivig32	10.3	S100A12, IL1RAPL2, IFNB1, ELN
4	sumatriptan32 34 9 18 9	14.2	VIP, MAOA, HTR1A, HTR1B, HTR1D, HTR2A
5	carbachol32 9 9	12.1	SST, KRIT1, HCRT, TAC1, KNG1, ADORA1
6	haloperidol32 34 9 9	12.9	VIP, BDNF, IL2RB, HTR1A, HTR2A, HTR3A
7	n acetylcysteine32	9.9	SELE, SETD2, VCAM1, BDNF, IL2RA, IL2RB
8	paroxetine32 34 9 9	12.7	MAOA, HTR1A, HTR1B, HTR2A, HTR3A, DRD4
9	tetrodotoxin32	9.7	VIP, BDNF, APOE, HTR3A, CALCA, NOS1
10	atropine32 9 9	11.7	VIP, GNAI1, CALCA, SST, PNOC, NOS1
11	morphine32 9 9	11.6	VIP, IL1RN, DRD2, PNOC, NOS1, NOS3
12	fluoxetine32 34 9 9	12.6	BDNF, MAOA, HTR1A, HTR1B, HTR2A, HTR2C
13	gnrh32	9.5	INS, CCL2, IGF1, HTR2C, PDYN, EDNRA
14	pge132	9.3	VIP, IL1RN, APOH, F5, GNAI1, PPBP
15	quetiapine32 9 18 9	12.2	BDNF, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B
16	cyclic amp32 18	10.2	SETD2, BDNF, IL1RAPL2, IL2RB, HTR1B, HTR1D
17	sulfasalazine32 9 9	11.2	SELE, MTHFR, CD40LG, IL1B, IL1RAPL2, IL1RN
18	cysteine32	9.2	SERPINA1, MTHFR, CD40LG, IFNG, HTR2C, ALB
19	sodium nitroprusside32	9.2	VIP, APP, SST, PDE5A, EDNRA, ELN
20	pramipexole32 9 9	11.0	BDNF, HTR1A, HTR1B, HTR1D, HTR2A, HTR2B
21	corticosterone32 18	9.9	VIP, BDNF, IL1B, IL1RAPL2, IL1RN, APP
22	clonidine32 9 9	10.8	IL1RAPL2, IGF1, GNB3, CALCA, SST, TGFB1
23	aspartate32	8.6	VIP, BDNF, CD40LG, IL2RB, APOE, APP
24	h2o232	8.4	SERPINA1, VIP, BDNF, IL1RAPL2, IL1RN, IL2RA
25	epinephrine32 9 18 9	11.4	SELE, VIP, BDNF, INS, IL1RAPL2, IL1RN
26	prostaglandin32	8.3	VIP, IL1B, IL1RAPL2, IL1RN, IL6, IFNB1
27	olanzapine32 34 9 18 9	12.2	BDNF, INS, APOE, HTR1A, HTR1B, HTR1D
28	fibrinogen32	8.2	SELE, SERPINA1, VCAM1, CD40LG, INS, IL1RAPL2
29	glutamate32	8.0	VIP, MTHFR, ATP1A2, INS, IL1RAPL2, APOH
30	thyroxine32 18	9.0	VIP, CD40LG, INS, IL2RB, IL4, APOE
31	5-hydroxytryptamine32	7.9	VIP, IL1RAPL2, APP, MAOA, IDO1, HTR1A
32	histamine32 18	8.9	SELE, VIP, VCAM1, BDNF, CD40LG, IL1RAPL2
33	nmda32 42	8.7	BDNF, IL1RAPL2, IL1RN, APOE, APP, MAOA
34	losartan32 34 9 9	10.7	SELE, VCAM1, APOE, CCL2, IGF1, ALB
35	pdtc32	7.6	SELE, SETD2, VCAM1, IL1B, IL4, IL6
36	dopamine32 9 18 9	10.5	SELE, VIP, CLOCK, BDNF, MTHFR, CD40LG
37	calcium32 9 18 9	10.4	VIP, BDNF, KCNK18, S100A12, MSX2, ATP1A2
38	infliximab32 9 9	9.4	SELE, IL1B, IL1RAPL2, IL1RN, IL2RA, IL2RB
39	estrogen32	7.2	SETD2, SERPINA1, VIP, BDNF, MTHFR, INS
40	il 1032	6.9	IL1B, IL1RAPL2, IL1RN, IL2, IL2RA, IL2RB
41	prostacyclin32	6.8	SELE, VIP, VCAM1, IL1B, APOE, APOH
42	lactate32	6.6	SELE, SETD2, VIP, VCAM1, BDNF, CD40LG
43	adenylate32	6.5	SELE, VIP, VCAM1, BDNF, CD40LG, IL1RAPL2
44	lipid32	6.3	SELE, SETD2, SERPINA1, VCAM1, BDNF, INS
45	indomethacin32 9 9	7.7	VIP, BDNF, CD40LG, IL1B, IL1RAPL2, IL1RN
46	cholesterol32 9 18 9	8.4	SELE, SERPINA1, VCAM1, BDNF, MTHFR, INS
47	retinoic acid32 42 18	6.7	SETD2, VCAM1, BDNF, MTHFR, CD40LG, IL1B
48	actinomycin d32	4.5	SELE, SETD2, BDNF, CD40LG, IL1B, IL1RAPL2
49	dexamethasone32 42 34 9 9	8.0	VIP, VCAM1, CD40LG, INS, IL1B, IL1RAPL2
50	alanine32	INF	SELE, VIP, VCAM1, CD40LG, INS, IL1RN

Cellular components related to headache according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	axon	GO:030424	9.6	APP, DRD2, SLC6A3, TAC1, HTR3A, ANXA3
2	neuronal cell body	GO:043025	8.7	CALCA, APOE, ANXA3, SST, CCL2, TGFB1
3	external side of plasma membrane	GO:009897	8.5	VCAM1, IL2RB, ICAM1, IL4, IFNG, TNF
4	platelet alpha granule lumen	GO:031093	8.3	SERPINA1, APP, F5, ALB, PF4, TGFB1
5	extracellular region	GO:005576	4.2	SERPINA1, CALCA, HP, SST, PPBP, PNOC
6	extracellular space	GO:005615	3.6	ABP1, ACE, TTR, TGFB1, TAC1, SOD1
7	plasma membrane	GO:005886	INF	CD40LG, IL1RN, IL2RA, IL2RB, APOE, APP
8	integral to plasma membrane	GO:005887	INF	DRD4, EDNRA, HCRTR2, HFE, TLR3, TACR1

Biological processes related to headache according to GeneDecks:

(show top 50)    (show all 74)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of vasodilation	GO:045909	10.6	NOS1, CALCA, INS, NOS3, ADM
2	leukocyte cell-cell adhesion	GO:007159	10.6	CALCA, ICAM1, VCAM1, CD40LG, SELE
3	negative regulation of potassium ion transport	GO:043267	10.6	HCRT, NOS3, NOS1, HTR2A
4	serotonin receptor signaling pathway	GO:007210	10.5	HTR3A, HTR2B, HTR2C, HTR2A
5	neuropeptide signaling pathway	GO:007218	10.5	HCRT, TAC1, NPY, HCRTR2, PDYN, PNOC
6	G-protein coupled receptor internalization	GO:002031	10.5	CALCA, HTR2B, ADM, HTR1B, DRD2
7	negative regulation of synaptic transmission, glutamatergic	GO:051967	10.5	HTR2A, DRD2, HTR1B, ADORA1
8	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	GO:007187	10.4	HTR7, HTR6, HTR1D, HTR1B, CCL2, NPY
9	positive regulation of vasoconstriction	GO:045907	10.3	PDE5A, TACR1, HTR2A, ICAM1, PTGS2
10	feeding behavior	GO:007631	10.3	NPY, BDNF, HTR2C, CALCA, DRD2, HCRTR2
11	neurotransmitter biosynthetic process	GO:042136	10.2	COMT, SLC6A3, MAOA, NOS1
12	positive regulation of MAP kinase activity	GO:043406	10.2	PDCD10, HTR2B, HTR2A, TNF, PDE5A, TGFB1
13	behavior	GO:007610	10.1	NPY, TACR1, MAOA, IDO1, HTR1A
14	negative regulation of blood pressure	GO:045776	10.1	CALCA, DRD2, NPY, ADORA1, ADIPOQ
15	positive regulation of renal sodium excretion	GO:035815	10.0	DRD2, KNG1, TAC1, TACR1
16	response to morphine	GO:043278	9.9	TAC1, TACR1, EDNRA, DRD2, IL1B
17	response to lipopolysaccharide	GO:032496	9.8	SERPINA1, SELE, PTGS2, COMT, PDE5A, EDNRA
18	blood circulation	GO:008015	9.8	F5, ELN, HTR7, ADM, EPO, MTHFR
19	synaptic transmission	GO:007268	9.8	HTR1B, CACNA1A, SST, PNOC, COMT, PDYN
20	elevation of cytosolic calcium ion concentration	GO:007204	9.8	ADM, KNG1, TAC1, TACR1, HCRT, EDNRA
21	G-protein coupled receptor signaling pathway	GO:007186	9.7	CX3CR1, APOE, SST, EDNRA, GNB3, GNAI1
22	chronic inflammatory response to antigenic stimulus	GO:002439	9.7	IL1RN, TNF, IL1B
23	regulation of blood pressure	GO:008217	9.7	ATP1A2, SOD1, ACE, NOS3, PTGS2, CALCA
24	response to organic cyclic compound	GO:014070	9.6	IL1RN, IL4, ICAM1, COMT, SERPINA1, NOS3
25	memory	GO:007613	9.6	SLC6A4, IL1B, HTR2A, PSEN1, IL1RN, PTGS2
26	defense response to bacterium	GO:042742	9.6	IFNG, NOS2, TLR3, IFNB1, ANXA3, PPBP
27	lipopolysaccharide-mediated signaling pathway	GO:031663	9.6	IL1B, TNF, CCL2, NOS3, TGFB1
28	female pregnancy	GO:007565	9.6	ADM, IL4, ADCYAP1, PRL, TGFB1, HFE
29	negative regulation of fat cell differentiation	GO:045599	9.5	MSX2, IL6, TNF, TGFB1, ADIPOQ
30	response to heat	GO:009408	9.5	CCL2, IL1B, CALCA, SST, NOS1, NOS3
31	aging	GO:007568	9.4	EDNRA, HTR2A, IL1B, VCAM1, CALCA, NOS3
32	response to ethanol	GO:045471	9.4	SOD1, ICAM1, IL4, NOS3, ADIPOQ, ADH7
33	regulation of insulin secretion	GO:050796	9.4	CACNA1A, TNF, IL1B, IFNG, SLC2A1, NOS2
34	embryo implantation	GO:007566	9.4	IL1B, CALCA, PTGS2, SOD1, EPO
35	positive regulation of nitric oxide biosynthetic process	GO:045429	9.3	IFNG, TNF, ICAM1, IL1B, PTGS2, INS
36	positive regulation of chemokine biosynthetic process	GO:045080	9.2	IFNG, TNF, IL1B, TLR3, IL4
37	positive regulation of apoptotic process	GO:043065	9.2	PTGS2, MSX2, KNG1, SOD1, TNF, IDO1
38	negative regulation of apoptotic process	GO:043066	9.1	TNF, ALB, HTR2B, IL6, IL1RN, INS
39	positive regulation of NF-kappaB transcription factor activity	GO:051092	8.9	IL1B, TGFB1, TLR3, TNF, ICAM1, IL6
40	response to hypoxia	GO:001666	8.8	ADIPOQ, ADM, ADORA1, SLC6A4, EDNRA, PDE5A
41	response to glucocorticoid stimulus	GO:051384	8.7	IL1B, IL1RN, IL6, ANXA3, TNF, PTGS2
42	positive regulation of cell proliferation	GO:008284	8.5	TGFB1, IL6, EPO, IGF1, PRTN3, HTR1A
43	platelet degranulation	GO:002576	8.5	F5, ALB, PPBP, PF4, TGFB1, SOD1
44	inflammatory response	GO:006954	8.5	CALCA, IL1B, S100A12, ADORA1, KNG1, TAC1
45	blood coagulation	GO:007596	8.1	NOS3, PDE5A, NOS2, PF4, GNAI1, TGFB1
46	cytokine-mediated signaling pathway	GO:019221	8.1	PF4, ICAM1, IFNG, IFNB1, CCL2, VCAM1
47	platelet activation	GO:030168	8.0	APP, IGF1, F5, ALB, GNAI1, PPBP
48	anti-apoptosis	GO:006916	8.0	APOE, IGF1, CD40LG, CCL2, IL1B, EPO
49	negative regulation of cell proliferation	GO:008285	7.7	NOS3, DRD2, PTGS2, IFNB1, TGFB1, ADM
50	response to drug	GO:042493	7.5	PTGS2, DRD2, TNF, HTR2C, SLC6A4, SLC6A3

Molecular functions related to headache according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	tetrahydrobiopterin binding	GO:034617	10.5	NOS1, NOS2, NOS3
2	neuropeptide hormone activity	GO:005184	10.5	HCRT, PNOC, VIP, NPY, ADCYAP1
3	nitric-oxide synthase activity	GO:004517	10.4	NOS2, NOS3, NOS1
4	serotonin binding	GO:051378	10.3	HTR1D, HTR3A, MAOA, HTR1A, HTR1B, HTR2A
5	serotonin receptor activity	GO:004993	10.2	HTR2A, HTR1A, HTR1B, HTR1D, HTR2B, HTR7
6	arginine binding	GO:034618	10.1	NOS1, NOS2, NOS3
7	drug binding	GO:008144	9.3	DRD2, ALB, HTR2C, ACE, HTR2B, DRD4
8	heparin binding	GO:008201	9.2	KNG1, ABP1, CCL2, APP, APOH, APOE
9	receptor binding	GO:005102	9.1	APP, CCL2, CALCA, NOS2, ADCYAP1, ADM
10	hormone activity	GO:005179	8.8	ADM, SST, CALCA, IGF1, INS, VIP
11	cytokine activity	GO:005125	8.1	IFNG, CD40LG, IL1B, IL2, IL4, IL6
12	growth factor activity	GO:008083	7.6	IGF1, IL6, IL4, IL2, IL1B, TGFB1
13	protein binding	GO:005515	4.4	TACR1, TGFB1, TTR, HFE, ELN, ACE