MCID: HDC001
MIFTS: 43

Headache malady

Neuronal diseases category

Summaries for Headache

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Sources:
33MedlinePlus, 43NINDS, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Almost everyone has had a headache. headache is the most common form of pain. it's a major reason people miss days at work or school or visit the doctor. the most common type of headache is a tension headache. tension headaches are due to tight muscles in your shoulders, neck, scalp and jaw. they are often related to stress, depression or anxiety. you are more likely to get tension headaches if you work too much, don't get enough sleep, miss meals, or use alcohol. other common types of headaches include migraines, cluster headaches, and sinus headaches. most people can feel much better by making lifestyle changes, learning ways to relax and taking pain relievers. not all headaches require a doctor's attention. but sometimes headaches warn of a more serious disorder. let your health care provider know if you have sudden, severe headaches. get medical help right away if you have a headache after a blow to your head, or if you have a headache along with a stiff neck, fever, confusion, loss of consciousness, or pain in the eye or ear. nih: national institute of neurological disorders and stroke

MalaCards: Headache is related to migraine and hypertension. An important gene associated with Headache is EDNRA (endothelin receptor type A), and among its related pathways are Endothelin and G alpha (q) signalling events. The compounds acetylcholine and sumatriptan have been mentioned in the context of this disorder. Affiliated tissues include eye, and related mouse phenotypes are behavior/neurological and renal/urinary system.

NINDS:43 There are four types of headache:

Wikipedia:63 A headache or cephalalgia is pain anywhere in the region of the head or neck. It can be a symptom of a... more...

Aliases & Classifications for Headache

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Sources:
43NINDS, 33MedlinePlus, 25ICD10
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Related Diseases for Headache

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Headache via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 538)
idRelated DiseaseScoreTop Affiliating Genes
1migraine31.3HTR3A, VIP, CALCA, CACNA1A, HTR1B, HTR2A
2hypertension30.7EDNRA, NPY, CALCA, GNB3
3migraine without aura30.6NPY, CACNA1A
4cluster headache30.4PNOC, HTR3A, VIP, CACNA1A, CALCA, HCRTR2
5sleep disorder30.2CLOCK, HCRTR2
6cadasil30.2GNB3, VIP, PNOC, HTR3A, EDNRA, PF4
7familial hemiplegic migraine30.2CACNA1A
8ischemia30.1HP, PF4, VIP, EDNRA, PNOC
9obesity30.1HTR2A, NPY, EDNRA, HCRTR2, CLOCK, GNB3
10vasculitis30.1S100A12
11myocardial infarction30.0HTR3A, AKR1A1, PF4, GNB3, HTR2A, NPY
12pheochromocytoma30.0HCRTR2, EDNRA, NPY, CALCA, VIP
13neuropathy30.0CALCA, CACNA1A
14drug dependence29.9PNOC
15generalized anxiety disorder29.9HTR3A, HTR2A
16chronic fatigue syndrome29.9VIP
17rhinitis29.9EDNRA, NPY, VIP
18dementia29.9HTR3A, HTR2A
19phaeochromocytoma29.9CALCA, NPY
20acute myocardial infarction29.8HTR2A, HTR3A, PF4
21anorexia nervosa29.8NPY, HTR2A, HTR3A
22uremia29.8PF4
23anxiety disorder29.8NPY, HTR2A, HTR3A
24coronary artery disease29.8HP, HTR3A, PF4, GNB3
25nephrotic syndrome29.8HP
26arthritis29.5VIP, CALCA, S100A12, HP
27epilepsy syndrome29.5PNOC, VIP, CACNA1A, HTR3A, NPY, HP
28substance abuse29.5ADH4
29mood disorder29.5NPY, CLOCK, GNB3, HTR1B, HTR3A, HTR2A
30fibromyalgia29.5HTR3A, HTR2A, NPY, PNOC
31dyspepsia29.5HTR3A
32panic disorder29.5HTR2A, HTR3A
33constipation29.5HTR3A, VIP
34paraganglioma29.5CALCA
35adenocarcinoma29.5PF4, VIP, EDNRA
36eating disorder29.5HTR2A, NPY, HTR3A
37asthma29.5HTR2A, S100A12, EDNRA, VIP
38complex regional pain syndrome29.5NPY, CALCA
39bipolar disorder29.5HTR2A, HTR3A
40status epilepticus29.5NPY
41parkinson's disease29.5HTR1B, HTR3A, AKR1A1, HTR2A
42intracranial hypotension10.6
43cerebritis10.5
44migraine with aura10.4
45intracranial hypertension10.4
46carotid artery dissection10.4
47cervicitis10.4
48meningitis10.3
49papilledema10.3
50patent foramen ovale10.3

Graphical network of the top 20 diseases related to Headache:



Diseases related to headache

Clinical Features for Headache

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Drugs & Therapeutics for Headache

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Headache

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Anatomical Context for Headache

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32MalaCards
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MalaCards organs/tissues related to Headache:

32
Eye

Animal Models for Headache or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Headache:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538610.5ADH7, VIP, CALCA, CACNA1A, HTR1B, HTR3A
2MP:000536710.5HTR3A, NPY, EDNRA, AKR1A1, HP, CALCA
3MP:000537610.4HTR3A, CACNA1A, CALCA, VIP, NPY, EDNRA
4MP:000363110.2CALCA, CACNA1A, GNB3, HTR3A, NPY, EDNRA

Publications for Headache

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Genetic Variations for Headache

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Expression for genes affiliated with Headache

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Headache

Search GEO for disease gene expression data for Headache.

Pathways for genes affiliated with Headache

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Sources:
37NCBI BioSystems Database, 53Reactome, 29KEGG, 51QIAGEN, 49PharmGKB, 12EMD Millipore
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Pathways related to Headache according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.5EDNRA, NPY, CALCA
2
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10.5GNB3, HTR2A, EDNRA, HCRTR2
3
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10.5ADH7, ADH4
4
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10.5ADH7, ADH4
5
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10.5VIP, CALCA, GNB3, HTR1B, HTR2A, HTR1D
6
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10.5HTR1D, HTR2A, HTR3A, HTR1B, GNB3, CACNA1A
7
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10.5HTR1B, HTR3A, HTR2A, HTR1D
8
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10.5CACNA1A, GNB3, HTR1B, HTR3A, HTR2A, HTR1D
9
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10.5PNOC, CALCA, GNB3, HTR1B, HTR2A, HTR1D
10
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10.5ADH7, ADH4, AKR1A1
11
Hide members
10.5AKR1A1, ADH4, ADH7

Compounds for genes affiliated with Headache

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Headache according to GeneCards/GeneDecks:

(show top 50)    (show all 190)
idCompoundScoreTop Affiliating Genes
1acetylcholine44 49 28 11 2414.9PNOC, CALCA, CACNA1A, HTR3A, EDNRA, HCRTR2
2sumatriptan44 28 59 49 11 2415.9VIP, HTR2A, HTR3A, HTR1B, GNB3, CALCA
3norepinephrine44 11 2412.9EDNRA, PNOC, PF4, VIP, CALCA, GNB3
4histamine44 28 2412.9HCRTR2, VIP, PNOC, HTR3A, CALCA, NPY
5adenylate4410.9NPY, HTR1D, HTR3A, CALCA, VIP, AKR1A1
65-hydroxytryptamine4410.9PF4, NPY, HTR1D, HTR2A, HTR3A, HTR1B
7cyanopindolol44 2811.9HTR2A, HTR1B, HTR3A, HTR1D
8dopamine44 28 11 2413.9PNOC, VIP, HTR3A, HTR2A, HTR1D, NPY
9ru 2496928 4411.9HTR2A, HTR1B, HTR3A, HTR1D
10yohimbine44 28 2 1113.9HTR1D, NPY, HTR3A, HTR1B, HTR2A
112-methyl-5-ht44 2811.9HTR2A, HTR3A, HTR1D, HTR1B
12guanethidine44 1111.9VIP, NPY, PNOC, CALCA
135-carboxamidotryptamine4410.9HTR3A, HTR2A, HTR1D, HTR1B
14ipsapirone44 2811.9HTR1B, HTR3A, HTR2A, HTR1D
15haloperidol44 28 2 49 1114.9NPY, VIP, HTR1D, HTR2A, AKR1A1, HTR3A
16dihydroergotamine28 44 1112.9HTR1B, HTR2A, HTR1D, HTR3A
17zotepine44 2811.9HTR1B, HTR3A, HTR2A, HTR1D
18methiothepin44 2811.9HTR1D, HTR2A, HTR3A, HTR1B
19ritanserin28 4411.9HTR3A, HTR2A, HTR1D, HTR1B
20metergoline44 2811.9HTR1D, HTR2A, HTR3A, HTR1B
21tetrodotoxin44 59 2812.9EDNRA, VIP, CALCA, HTR3A, NPY
22olanzapine49 44 28 11 2414.9GNB3, HTR1D, HTR2A, HTR1B, HTR3A
23methysergide44 28 1112.9HTR1B, HTR1D, HTR3A, HTR2A
24atropine44 28 1112.9PNOC, NPY, CALCA, EDNRA
25tryptamine44 28 2412.9HTR2A, HTR3A, HTR1B, HTR1D
26capsaicin44 2811.9NPY, PNOC, S100A12, VIP, CALCA
27fenfluramine28 44 1112.8HTR3A, HTR1B, NPY, HTR2A
28propranolol44 28 49 11 2414.8HTR1D, VIP, HTR3A, HTR1B, CALCA
29ergotamine28 44 1112.8HTR1D, HTR2A, HTR3A, HTR1B
30ketanserin28 4411.8HTR3A, HTR1D, HTR1B, HTR2A
31triptan4410.8HTR3A, CALCA, HTR1B
32(tfmpp)4410.8HTR3A, HTR2A, HTR1B
33calcium44 49 11 2413.8PNOC, VIP, CALCA, ANXA3, EDNRA, HTR2A
34clozapine44 28 49 1113.8HTR2A, HTR1D, GNB3, HTR1B, HTR3A
35aripiprazole28 49 44 11 2414.8HTR3A, HTR1B, HTR1D, HTR2A
36cgs-120662810.8HTR1D, HTR2A, HTR1B
37gr 1279354410.8HTR3A, HTR1D, HTR2A
38frovatriptan44 1111.7HTR1D, HTR3A, HTR1B
39sb 2242892810.7HTR1D, HTR1B, HTR2A
40pipamperone28 4411.7HTR1D, HTR2A, HTR1B
411-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane4410.7HTR1B, HTR3A, HTR2A
42phosphoramidon44 1111.7VIP, NPY, EDNRA, CALCA
43ziprasidone49 28 44 1113.7HTR1D, HTR3A, HTR1B, HTR2A
44paroxetine44 49 28 1113.6HTR1B, HTR3A, HTR2A, PF4
45sb 2166412810.6HTR1D, HTR2A, HTR1B
46s330842810.5HTR1B, HTR1D, HTR2A
47indomethacin44 59 28 1113.5NPY, VIP, CALCA, EDNRA, AKR1A1, PF4
489-oh-risperidone2810.5HTR1B, HTR2A, HTR1D
49epinephrine44 11 2412.4VIP, NPY, PF4, CALCA, GNB3, HP
50helospectin4410.2CALCA, VIP, NPY

GO Terms for genes affiliated with Headache

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Sources:
16Gene Ontology
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Cellular components related to Headache according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.5HTR3A, HTR2A, HTR1D, EDNRA, HCRTR2, HTR1B
2extracellular regionGO:00557610.5ADH7, VIP, CALCA, S100A12, NPY, HP
3neuronal cell bodyGO:04302510.4VIP, CALCA, CACNA1A, HTR3A
4plasma membraneGO:00588610.2CACNA1A, S100A12, GNB3, HTR1B, HTR3A, HTR2A

Biological processes related to Headache according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1regulation of blood pressureGO:00821710.8CALCA, GNB3, NPY, EDNRA
2synaptic transmissionGO:00726810.8PNOC, CACNA1A, GNB3, HTR1B, HTR3A, HTR2A
3regulation of behaviorGO:05079510.8HTR1D, HTR2A, HTR1B
4vasoconstrictionGO:04231010.8EDNRA, HTR1D, HTR1B
5neuropeptide signaling pathwayGO:00721810.8CALCA, NPY, HCRTR2, PNOC
6feeding behaviorGO:00763110.8HCRTR2, NPY, CALCA
7G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:00718710.7NPY, HTR1D, HTR1B
8negative regulation of synaptic transmission, glutamatergicGO:05196710.7HTR1B, HTR2A
9positive regulation of macrophage differentiationGO:04565110.7CALCA, PF4
10negative regulation of cAMP biosynthetic processGO:03081810.7HTR1B, EDNRA
11regulation of dopamine secretionGO:01405910.7HTR1B, HTR2A
12serotonin receptor signaling pathwayGO:00721010.7HTR3A, HTR2A
13negative regulation of potassium ion transportGO:04326710.7VIP, HTR2A
14cellular aldehyde metabolic processGO:00608110.6AKR1A1, ADH4
15ethanol oxidationGO:00606910.6ADH4, ADH7
16G-protein coupled receptor internalizationGO:00203110.6CALCA, HTR1B
17agingGO:00756810.5EDNRA, HTR2A, CALCA
18defense response to bacteriumGO:04274210.5HP, ANXA3, S100A12
19elevation of cytosolic calcium ion concentrationGO:00720410.4CALCA, CACNA1A, EDNRA
20elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayGO:05148210.2EDNRA, CALCA

Molecular functions related to Headache according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1serotonin bindingGO:05137810.7HTR1D, HTR2A, HTR3A, HTR1B
2serotonin receptor activityGO:00499310.6HTR1D, HTR2A, HTR3A, HTR1B
3neuropeptide hormone activityGO:00518410.6VIP, NPY, PNOC
4alcohol dehydrogenase activity, zinc-dependentGO:00402410.5ADH7, ADH4
5retinol dehydrogenase activityGO:00474510.5ADH7, ADH4
6alditol:NADP+ 1-oxidoreductase activityGO:00403210.5ADH4, AKR1A1
7alcohol dehydrogenase (NAD) activityGO:00402210.4ADH4, ADH7
8retinol bindingGO:01984110.2ADH7, ADH4

Products for genes affiliated with Headache

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  • Antibodies
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  • Lysates
  • Antibodies

Sources for Headache

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet