Hearing Loss malady

Wikipedia: Deafness, hearing impairment, or hearing loss is a partial or total inability to hear.⁴⁴ more...

MalaCards: Hearing Loss, also known as deafness, is related to nonsyndromic deafness and sensorineural hearing loss. An important gene associated with Hearing Loss is SERPINB6 (serpin peptidase inhibitor, clade B (ovalbumin), member 6), and among its related pathways are Cellular Apoptosis Pathway and Metabolic pathways. The compounds h2o2 and actinomycin d have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and kidney, and related mouse phenotypes are tumorigenesis and normal.

hearing loss 7 deafness 43

Diseases related to hearing loss by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1327)

id	Related Disease	Score	Top Affiliating Genes
1	nonsyndromic deafness	41.2	COCH, KIAA1199, PCDH15, MYO6, MYO15A, MYO1A
2	sensorineural hearing loss	39.5	PAX2, KCNQ4, GJB2, GJB3
3	usher syndrome	35.4	COCH, PCDH15, MYO15A, MYO7A, USH1C, USH2A
4	enlarged vestibular aqueduct	35.2	MYO15A, KCNJ10, ATP6V0A4, EYA1, GJB2, GJB3
5	pendred syndrome	35.0	PAX3, MITF, GJB2, COL4A5, SLC26A4, SLC26A5
6	dfnb1	33.9	PCDH15, MYO7A, GJB2, GJB6, OTOF
7	neuropathy	33.0	SGCA, BTD, SERPINE1, BDNF, BCS1L, SCN4A
8	neuronitis	32.9	LRP4, LRP2, SGCA, RDX, PCDH15, BTD
9	optic atrophy	32.2	BTD, RAB3GAP1, MT-ND5, MT-ND1, MT-ND6, CCDC50
10	cataract	31.9	RAB3GAP1, CLCN1, SCN4A, MTHFR, ATP7A, ATP7B
11	peripheral neuropathy	31.8	BDNF, MTHFR, MT-ND1, MTR, SACS, MPZ
12	retinitis	31.7	LRP2, LRP5, COCH, PCDH15, SERPINC1, SETD2
13	ophthalmoplegia	31.7	MT-TL2, MT-RNR1, SALL4, C10orf2, OPA1, SOD2
14	myopathy	31.6	SGCA, BTD, CLCN1, PAX3, BDNF, SCN4A
15	fabry disease	31.5	SERPINC1, GUSB, IL1A, APOH, MANBA, F5
16	congenital deafness with labyrinthine aplasia, microtia, and microdontia	31.5	MYO15A, MYO7A, KCNE1, KCNQ1, EYA1, GJB2
17	congenital cataracts	31.2	RAB3GAP1, ATP7A, ATP7B, EYA1, COL4A5, GFER
18	stickler syndrome	31.1	BARX1, MTHFR, MTR, CDH1, ITGB3, GSTM1
19	nonsyndromic hearing loss and deafness	31.0	MT-TS1, MT-RNR1, GJB2, GJB6
20	kid syndrome	31.0	GJB2, GJB3, GJB4, GJB6
21	cytomegalovirus infection	31.0	MTHFR, MT-RNR1, CDH1, APOE, F5, HSPA4
22	branchiootorenal syndrome	30.7	PAX2, EYA1, SIX1, SIX5
23	keratitis	30.3	GUSB, GSR, FGF2, IL1A, IFNA1, IFNA2
24	auditory neuropathy	30.3	MPZ, GJB2, GJB6, DIAPH3, OTOF, DFNB59
25	usher syndrome type 3	30.1	PCDH15, MYO7A, USH1C, USH2A, CDH23, GPR98
26	osteogenesis imperfecta	30.1	LRP5, CD36, FGFR3, PLOD2, COL1A1, COL1A2
27	amyloidosis	30.1	SERPINC1, GSN, FGFR3, APOA1, APOE, IFNA2
28	myotonic dystrophy	30.0	SGCA, MYO1A, CLCN1, SCN4A, MT-ND5, APOE
29	skin disease	29.9	BDNF, MITF, FGFR2, FGFR3, IL1A, HSPA4
30	antiphospholipid syndrome	29.9	SERPINC1, SERPINE1, MTHFR, ITGB3, APOH, F5
31	ataxia	29.9	LRP2, BTD, SETD2, SERPINE1, USH1C, USH2A
32	albinism	29.7	PAX3, MITF, GUSB, GSR, GSTM1, GSTT1
33	hepatitis	29.7	XDH, GUSB, GSR, IFNA1, IFNA2, F2
34	pierre robin sequence	29.7	COL11A2, COL9A2, COL11A1, COL2A1, COL9A1
35	pseudoainhum	29.7	GJB2, GJB3, GJB4, GJB6
36	hypotonia	29.6	BTD, MT-CO1, ATP7A, ATP7B, MPZ, FLNA
37	usher syndrome type i	29.6	PCDH15, MYO7A, USH1C, CDH23
38	epidermodysplasia verruciformis	29.6	TMC7, TMC3, TMC8, TMC4, TMC5, TMC6
39	macrothrombocytopenia	29.5	CD36, ITGB3, FLNA, GJB2, GJB3, MYH9
40	otitis media	29.5	SERPINC1, SERPINE1, IL1A, FBXO11, IFNA1, F5
41	usher syndrome, type 1f	29.5	COCH, PCDH15, MYO7A, USH1C
42	friedreich ataxia	29.5	SACS, GSR, PPARG, SMPX, G6PD, SOD1
43	axonal neuropathy	29.3	SACS, MPZ, FGFR2, IFNA2, GJB1, C10orf2
44	synostosis	29.3	FMN1, FGF10, FGFR2, FGFR3, GREM1, NOG
45	seizures	29.3	BTD, BDNF, KCNQ1, KCNJ10, MT-ND5, MT-CO1
46	leber hereditary optic neuropathy	29.2	MT-ND5, MT-CO1, MT-ND1, MT-ND6, OPA1, EPHX1
47	chondrodysplasia	29.2	CD36, FGFR2, FGFR3, HSD17B4, CAT, COL1A1
48	craniosynostosis	29.1	LRP5, FGF10, FGF2, FGFR2, FGFR3, ANKH
49	spasticity	29.1	BTD, RAB3GAP1, MTHFR, MT-ATP6, MT-ND1, MT-ND6
50	headache	29.1	SETD2, BDNF, MTHFR, APOE, APOH, F5

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to hearing loss:

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MGI Mouse Phenotypes related to hearing loss:

²⁵ (show all 30)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	tumorigenesis	MP:0002006	INF	SERPINE1, PAX3, SDHD, CDH1, ITGB3, FGF2
2	normal phenotype	MP:0002873	INF	, COCH, SERPINB6, PAX3, BDNF, SDHD
3	behavior/neurological phenotype	MP:0005386	INF	, LRP2, , SGOL2, RDX, PCDH15
4	homeostasis/metabolism phenotype	MP:0005376	INF	, LRP2, , SGCA, RDX, BTD
5	limbs/digits/tail phenotype	MP:0005371	INF	, , PAX3, BAX, MTHFR,
6	digestive/alimentary phenotype	MP:0005381	INF	LRP2, MYO1A, PAX3, BDNF, KCNE1, KCNQ1
7	craniofacial phenotype	MP:0005382	INF	, LRP2, , MYO6, ZFAND5, PAX3
8	adipose tissue phenotype	MP:0005375	INF	SERPINE1, ZFAND5, XDH, CD36, GUSB,
9	immune system phenotype	MP:0005387	INF	, SGCA, MYO1F, PAX3, PATZ1, CHST2
10	pigmentation phenotype	MP:0001186	INF	, BTD, SERPINC1, MYO7A, PAX3,
11	liver/biliary system phenotype	MP:0005370	INF	, RDX, SERPINC1, ATP7A, ATP7B, CD36
12	integument phenotype	MP:0010771	INF	, BTD, CLCN1, CLCN6, PAX3, BDNF
13	vision/eye phenotype	MP:0005391	INF	LRP2, , PCDH15, BTD, SERPINC1, MYO6
14	other phenotype	MP:0005395	9.7	ATP7B, ITGB3, FOXC1, GRHL2, APOE, ANKH
15	respiratory system phenotype	MP:0005388	INF	, LRP2, ZFAND5, PAX3, BDNF, ATP7A
16	hearing/vestibular/ear phenotype	MP:0005377	INF	LRP2, COCH, RDX, PCDH15, MYO1C, MYO6
17	taste/olfaction phenotype	MP:0005394	INF	BDNF, ENO2, CASP3, CASP9, GJB4, TRPV1
18	growth/size phenotype	MP:0005378	INF	, LRP2, PCDH15, BTD, SETD2, SERPINE1
19	reproductive system phenotype	MP:0005389	INF	, SGOL2, MYO6, MYO7A, USH1C, CLCN1
20	skeleton phenotype	MP:0005390	INF	, LRP2, CLCN1, ZFAND5, PAX3, BAX
21	nervous system phenotype	MP:0003631	INF	, , RDX, PCDH15, SERPINC1, MYO1C
22	cellular phenotype	MP:0005384	INF	LRP2, , SGOL2, MYO1F, CLCN6, ZFAND5
23	no phenotypic analysis	MP:0003012	INF	LRP2, SERPINB6, MYO1F, MYO7A, CLCN1, PAX3
24	endocrine/exocrine gland phenotype	MP:0005379	INF	, LRP2, , SGOL2, PAX3,
25	hematopoietic system phenotype	MP:0005397	INF	PAX3, PATZ1, KCNE1, ATP7B, , GSN
26	embryogenesis phenotype	MP:0005380	INF	, , SERPINC1, SETD2, PAX3, SDHD
27	mortality/aging	MP:0010768	INF	, , SERPINC1, SETD2, SERPINE1, MYO6
28	renal/urinary system phenotype	MP:0005367	INF	, LRP2, BTD, PAX3, , BAX
29	cardiovascular system phenotype	MP:0005385	INF	, SGCA, SERPINC1, SETD2, SERPINE1, ZFAND5
30	muscle phenotype	MP:0005369	INF	SGCA, BTD, CLCN1, ZFAND5, PAX3, SCN4A

Articles related to hearing loss:

(show top 50)    (show all 562)

id	Title	Authors	Year	Affiliating Genes
1	DFNA8/12 caused by TECTA mutations is the most identified subtype of nonsyndromic autosomal dominant hearing loss. (21520338)	Hildebrand M.S.... Moreno-Pelayo M.A.	2011	TECTA
2	Prevalence of the GJB2 IVS1+1G >A mutation in Chin ese hearing loss patients with monoallelic pathogenic mutation in the coding re gion of GJB2. (21122151)	Yuan Y.... Dai P.	2010	GJB2
3	Deletion of an enhancer near DLX5 and DLX6 in a famil y with hearing loss, craniofacial defects, and an inv(7)(q21.3q35). (19707792)	Brown K.K.... Morton C.C.	2010	DLX6
4	Prevalence of the c.35delG and p.W24X mutations in th e GJB2 gene in patients with nonsyndromic hearing loss from North-West Romania. (20096468)	LazA8r C.... Grigorescu-Sido P.	2010	GJB2
5	High level of intrafamilial phenotypic variability of non-syndromic hearing loss in a Lur family due to delE120 mutation in GJB2 gen e. (20609484)	Mahdieh N.... Zeinali S.	2010	GJB2
6	Study of mtDNA 12S rRNA A1555G, GJB2, GJB3 gene muta tion in Uighur and Han people with hereditary nonsyndromic hearing loss in Xinj iang. (21055240)	Li Y.H.... Zou G.H.	2010	GJB2, GJB3, MT-RNR1
7	Identification of Novel Variants in the Cx29 Gene of Nonsyndromic Hearing Loss Patients Using Buccal Cells and Restriction Fragment Length Polymorphism Method. (19657183)	Wang W.H.... Li S.Y.	2009	GJC3, GJE1
8	New evidence for the correlation of the p.G130V mutation in the GJB2 gene and syndromic hearing loss with palmoplantar keratoderma. (18688874)	Iossa S.... FranzAc A.	2009	GJB2
9	Relative contributions of radiation and cisplatin-bas ed chemotherapy to sensorineural hearing loss in head-and-neck cancer patients. (18707819)	Hitchcock Y.J.... Shrieve D.C.	2009	EGFR
10	Hearing loss in a mouse model of Muenke syndrome. (18818193)	Mansour S.L.... Wilkie A.O.	2009	FGFR3
11	Splice variant IVS2-2A>G in the SLC26A5 (Prestin) gene in five Estonian families with hearing loss. (19027966)	Teek R.... Ounap K.	2009	GJA1, GJB2, GJB3
12	Analysis of the GJB2 and GJB6 genes in Italian patients with nonsyndromic hearing loss: frequencies, novel mutations, genotypes, and degree of hearing loss. (19371219)	Primignani P.... Coviello D.A.	2009	GJB2, GJB6
13	A novel locus DFNA59 for autosomal dominant nonsyndromic hearing loss maps at chromosome 11p14.2-q12.3. (19030898)	Chatterjee A.... Anand A.	2009	DFNA59
14	Mutation in gap and tight junctions in patients with non-syndromic hearing loss. (19254696)	Belguith H.... Masmoudi S.	2009	GJB2, CLDN14, GJB3
15	Screening of the mitochondrial A1555G mutation in patients with sensorineural hearing loss. (19082356)	Maniglia L.P.... Maniglia J.V.	2008	RNR1
16	A novel WFS1 mutation in a family with dominant low frequency sensorineural hearing loss with normal VEMP and EcochG findings. (18518985)	Bramhall N.F.... Street V.A.	2008	WFS1
17	Epidemiological study of nonsyndromic hearing loss in Sicilian newborns. (17568408)	Niceta M.... Corsello G.	2007	GJB2
18	Autosomal recessive postlingual hearing loss (DFNB8): compound heterozygosity for two novel TMPRSS3 mutations in German siblings. (17551081)	Elbracht M.... Zerres K.	2007	TMPRSS3
19	The roles of connexin genes in sporadic hearing loss population (17672988)	Li Q.Z.... Han D.Y.	2007	GJB2, GJB3, GJB6
20	Vertical corneal striae in families with autosomal dominant hearing loss: DFNA9/COCH. (17368553)	Bischoff A.M.... Cruysberg J.R.	2007	COCH
21	Auditory brainstem response abnormalities and hearing loss in children with craniosynostosis. (17515438)	Church M.W.... Kazzi S.N.	2007	FGFR2
22	A novel hearing-loss-related mutation occurring in the GJB2 basal promoter. (17660464)	Matos T.D.... Fialho G.	2007	GJB2
23	Prostatic carcinoma that arose with hearing loss: a case report (17628942)	Sakuma T.... Kawano K.	2007	ENO2, KLK3
24	Maternally inherited non-syndromic hearing loss associated with mitochondrial 12S rRNA A827G mutation in a Chinese family. (16650816)	Xing G.... Cao X.	2006	GJB2, MT-RNR1
25	Mullerian anomalies, hearing loss, and connexin 26 mutations. (16650419)	Rabinson J.... Tur-Kaspa I.	2006	GJB2
26	Outcomes of clinical examination and genetic testing of 500 individuals with hearing loss evaluated through a genetics of hearing loss clinic. (16532460)	Yaeger D.... Krantz I.D.	2006	GJB2
27	Mutation of COL11A2 causes autosomal recessive non-syndromic hearing loss at the DFNB53 locus. (16033917)	Chen W.... Smith R.J.H.	2005	COL11A2, COL11A1
28	Sudden hearing loss and MTHFR 677C>T/1298A>C gene polymorphisms. (15775757)	Capaccio P.... Pignataro L.	2005	MTHFR
29	Congenital hearing loss. Molecular genetic diagnosis of connexin genes and genetic counselling (15502895)	Kunstmann E.... Sudhoff H.	2005	GJB3
30	A novel DFNA9 mutation in the vWFA2 domain of COCH alters a conserved cysteine residue and intrachain disulfide bond formation resulting in progressive hearing loss and site-specific vestibular and central oculomotor dysfunction. (16261627)	Street V.A.... Phillips J.O.	2005	COCH
31	The role of factor V Leiden and prothrombin G20210A mutations in sudden sensorineural hearing loss. (16015153)	Gorur K.... Ozsahinoglu C.	2005	F2, F5
32	SLC26A4/PDS genotype-phenotype correlation in hearing loss with enlargement of the vestibular aqueduct (EVA): evidence that Pendred syndrome and non-syndromic EVA are distinct clinical and genetic entities. (15689455)	Pryor S.P.... Griffith A.J.	2005	SLC26A4
33	Progressive hearing loss and increased susceptibility to noise-induced hearing loss in mice carrying a Cdh23 but not a Myo7a mutation. (14648237)	Holme R.H.... Steel K.P.	2004	CDH23, MYO7A
34	Mapping of a new autosomal recessive nonsyndromic hearing loss locus (DFNB32) to chromosome 1p13.3-22.1. (12634867)	Masmoudi S.... Ayadi H.	2003	COL11A1, DFNB32
35	High frequency of GJB2 mutation W24X among Slovak Romany (Gypsy) patients with non-syndromic hearing loss (NSHL). (15113126)	Minarik G.... Kadasi L.	2003	GJB2
36	Progressive hearing loss, and recurrent sudden sensorineural hearing loss associated with GJB2 mutations--phenotypic spectrum and frequencies of GJB2 mutations in Austria. (12189487)	Janecke A.R.... Nekahm-Heis D.	2002	GJB2
37	Mitochondrial DNA mutations and non-syndromic sensorineural hearing loss (12772452)	Kong W.... Cheng H.	2002	MT-ND5, MT-TL1, MT-RNR1
38	Mapping of a new autosomal dominant nonsyndromic hearing loss locus (DFNA30) to chromosome 15q25-26. (11571554)	Mangino M.... Dallapiccola B.	2001	DFNA30
39	Sensorineural hearing loss and the incidence of Cx26 mutations in Austria. (11313763)	Loffler J.... Janecke A.R.	2001	GJB2
40	Dentinogenesis imperfecta 1 with or without progressive hearing loss is associated with distinct mutations in DSPP. (11175790)	Xiao S.... Kong X.	2001	DSPP
41	Sensorineural hearing loss in distal renal tubular acidosis, nephrocalcinosis and microcytic anemia (11139892)	Ptok M.	2000	ATP6V1B1
42	2E4/Kaptin (KPTN) - a candidate gene for the hearing loss loci, DFNA4. (11409409)	Bearer E.L.... Jackson C.L.	2000	KPTN
43	High frequency hearing loss correlated with mutations in the GJB2 gene. (10830906)	Wilcox S.A.... Dahl H.-H.M.	2000	GJB2
44	A Pro51Ser mutation in the COCH gene is associated with late onset autosomal dominant progressive sensorineural hearing loss with vestibular defects. (9931344)	de Kok Y.J.M.... Cremers F.P.M.	1999	COCH
45	Description of a large kindred with autosomal dominant inheritance of branchial arch anomalies, hearing loss, and ear pits, and exclusion of the branchio-oto-renal (BOR) syndrome gene locus (chromosome 8q13.3). (9788564)	Stratakis C.A.... Rennert O.M.	1998	EYA1
46	Mutation in transcription factor POU4F3 associated with inherited progressive hearing loss in humans. (9506947)	Vahava O.... Avraham K.B.	1998	POU4F3
47	Identification and mutation analysis of a cochlear-expressed, zinc finger protein gene at the DFNB7/11 and dn hearing-loss loci on human chromosome 9q and mouse chromosome 19. (9758550)	Scott D.A.... Sheffield V.C.	1998	PATZ1, ZFAND5
48	A mutation causing Alport syndrome with tardive hearing loss is common in the western United States. (8651292)	Barker D.F.... Gregory M.C.	1996	COL4A5
49	Mutation in the alpha 5(IV) collagen chain in juvenil e-onset Alport syndrome without hearing loss or ocular lesions: detection by de naturing gradient gel electrophoresis of a PCR product. (1598909)	Zhou J.... Tryggvason K.	1992	COL4A5
50	Autosomal dominant sensorineural hearing loss. Pedigrees, audiologic findings, and temporal bone findings in two kindreds. (1910721)	Khetarpal U.... Holmes L.B.	1991	COCH

Genes related to hearing loss according to GeneCards:

(show top 50)    (show all 341)

id	Symbol	Description	Score	GeneCards Section Context
1	SERPINB6	serpin peptidase inhibitor, clade B (ovalbumin), member 6	11.1	Summaries, Publications, Functions
2	KCNQ4	potassium voltage-gated channel, KQT-like subfamily, member 4	11.1	Publications, Summaries
3	ABHD12	abhydrolase domain containing 12	11.1	Summaries
4	CIHL	hearing loss, cisplatin-induced, susceptibility to	11.1	Aliases & Descriptions
5	ACTG1	actin, gamma 1	11.1	Summaries, Publications
6	TMC1	transmembrane channel-like 1	11.1	Publications, Summaries
7	MCDR4	macular dystrophy, retinal, 4 (North Carolina type with progressive sensorineural hearing loss)	11.1	Aliases & Descriptions, Publications
8	TMIE	transmembrane inner ear	11.1	Summaries, Publications
9	PTPRQ	protein tyrosine phosphatase, receptor type, Q	11.1	Summaries, Publications
10	MYO6	myosin VI	11.1	Publications, Summaries
11	MYO3A	myosin IIIA	11.1	Publications, Summaries
12	EYA4	eyes absent homolog 4 (Drosophila)	11.1	Publications, Summaries
13	DIAPH1	diaphanous homolog 1 (Drosophila)	11.1	Publications, Summaries
14	PCDH15	protocadherin-related 15	11.1	Summaries, Publications
15	DFNB83	deafness, autosomal recessive 83	11.1	Summaries, Publications
16	MIR96	microRNA 96	11.1	Publications, Summaries
17	GJC3	gap junction protein, gamma 3, 30.2kDa	11.1	Publications, Summaries
18	CCDC50	coiled-coil domain containing 50	11.1	Summaries, Publications
19	LOXHD1	lipoxygenase homology domains 1	11.1	Summaries, Publications
20	GJB2	gap junction protein, beta 2, 26kDa	11.0	Publications
21	GJB6	gap junction protein, beta 6, 30kDa	11.0	Publications
22	MT-TS1	mitochondrially encoded tRNA serine 1 (UCN)	11.0	Publications
23	MT-RNR1	mitochondrially encoded 12S RNA	11.0	Publications
24	GJB3	gap junction protein, beta 3, 31kDa	11.0	Publications
25	SLC26A4	solute carrier family 26, member 4	11.0	Publications
26	MITF	microphthalmia-associated transcription factor	11.0	Publications
27	USH2A	Usher syndrome 2A (autosomal recessive, mild)	11.0	Publications
28	DLX5	distal-less homeobox 5	11.0	Aliases & Descriptions, Publications
29	COCH	coagulation factor C homolog, cochlin (Limulus polyphemus)	11.0	Publications
30	POU3F4	POU class 3 homeobox 4	11.0	Publications
31	WFS1	Wolfram syndrome 1 (wolframin)	11.0	Publications
32	ATP6V1B1	ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B1	11.0	Publications
33	COL11A2	collagen, type XI, alpha 2	11.0	Publications
34	MYO7A	myosin VIIA	11.0	Publications
35	OTOF	otoferlin	11.0	Publications
36	SOX2	SRY (sex determining region Y)-box 2	11.0	Publications
37	SLC29A3	solute carrier family 29 (nucleoside transporters), member 3	11.0	Publications
38	BTD	biotinidase	11.0	Publications
39	COL2A1	collagen, type II, alpha 1	11.0	Publications
40	FGFR3	fibroblast growth factor receptor 3	11.0	Publications
41	COL4A5	collagen, type IV, alpha 5	11.0	Publications
42	CDH23	cadherin-related 23	11.0	Publications
43	PAX3	paired box 3	11.0	Publications
44	NLRP3	NLR family, pyrin domain containing 3	11.0	Publications
45	COL11A1	collagen, type XI, alpha 1	11.0	Publications
46	MYH9	myosin, heavy chain 9, non-muscle	11.0	Publications
47	HSPA8	heat shock 70kDa protein 8	11.0	Publications
48	BDNF	brain-derived neurotrophic factor	11.0	Publications
49	GSTT1	glutathione S-transferase theta 1	11.0	Publications
50	GSTM1	glutathione S-transferase mu 1	11.0	Publications

Pathways related to hearing loss according to GeneDecks:

(show top 50)    (show all 124)

id	Pathway	Score	Top Affiliating Genes
1	Cellular Apoptosis Pathway36	INF	FGFR3, BDNF, FGF2, BAX, ,
2	Metabolic pathways20	INF	UGT1A6, UGT2B4, UGT1A5, UGT1A4, UGT1A3, UGT1A10
3	PAK Pathway36	INF	MYO3A, MYO1A, MYO15A, MYO6, CASP9, MYO1C
4	Blood Coagulation Cascade36	INF	COL2A1, COL9A3, F5, SERPINC1, KLK3,
5	Mitochondrial Apoptosis36	INF	CASP8, , BDNF, CASP3, FGFR3, CASP9
6	Intrinsic Prothrombin Activation Pathway36	INF	COL1A2, COL9A3, COL2A1, , KLK3, COL4A5
7	CDC42 Pathway36	INF	HLA-DRB1, MAPK8, HLA-DQB1, DIAPH1, , EGFR
8	Rho Family GTPases36	INF	, IL1A, COL11A2, , MAPK8, FGFR3
9	PTEN Pathway36	INF	, HGF, , FGF2, PRKCH, ACTG1
10	Drug metabolism - cytochrome P45020	11.6	GSTM3, GSTM4, ADH1B, GSTT1, AOX1, ADH4
11	Metabolism of xenobiotics by cytochrome P45020	11.4	UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2B11, UGT2B15
12	Retinol metabolism20	11.3	UGT1A1, ADH1C, ADH5, ADH7, ADH4, UGT1A10
13	Other types of O-glycan biosynthesis20	11.3	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6
14	Porphyrin and chlorophyll metabolism20	11.2	CP, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5
15	Ascorbate and aldarate metabolism20	11.2	UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7
16	Pentose and glucuronate interconversions20	11.2	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6
17	Starch and sucrose metabolism20	11.2	UGT1A3, UGT1A9, UGT1A1, UGT1A6, UGT1A7, UGT1A4
18	Steroid hormone biosynthesis20	11.1	UGT1A4, UGT1A1, UGT1A10, UGT1A3, UGT1A5, UGT1A6
19	Tamoxifen Pathway, Pharmacokinetics34	11.0	SULT1E1, FMO3, FMO1, UGT2B7, UGT2B15, UGT1A8
20	Valproic Acid Pathway, Pharmacokinetics34	10.9	UGT1A9, UGT1A3, UGT1A10, UGT1A4, UGT2B7, UGT2B15
21	Platinum Pathway, Pharmacokinetics/Pharmacodynamics34	10.9	SOD1, GSTT1, GSTM1, ATP7B, ATP7A, ABCG2
22	Estrogen Metabolism Pathway34	10.9	UGT1A3, UGT1A4, UGT1A8, UGT1A9, UGT2B7, UGT1A1
23	Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics34	10.9	TPMT, PRPS1, ABCC5, DHFR, AOX1, GSTM1
24	Irinotecan Pathway, Pharmacodynamics34	10.9	UGT1A10, UGT1A3, UGT1A9, UGT1A4, UGT1A6, UGT1A8
25	Drug metabolism - other enzymes20	10.8	UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9
26	Cellular Transformation by HTLV136	10.7	HSPA1A, MAPK8, HSPA1B, HSPA4, HSPA8, TNF
27	2-Naphthylamine and 2-Nitronaphtalene metabolism10	10.7	UGT1A1, UGT1A3, UGT1A4, UGT1A6, EPHX1, UGT1A9
28	Estradiol metabolism10	10.7	CYP1B1, UGT1A1, UGT2B11, UGT2B28, SULT1E1, UGT1A10
29	Estradiol metabolism41	10.7	SULT1E1, COMT, UGT1A1, UGT1A10, UGT2B11, UGT2B28
30	2-Naphthylamine and 2-Nitronaphtalene metabolism41	10.6	UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A8, UGT1A9
31	Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)41	10.6	HSPA1B, NOS1, NOS2, HSPA2, HSPA1A, HSPA1L
32	Toxoplasmosis20	9.8	HSPA2, HSPA1A, HSPA1L, MAPK8, HSPA1B, HSPA8
33	Apoptosis and survival_TNFR1 signaling pathway41	9.6	TNF, TNFRSF1A, DIABLO, CYCS, CASP8, BAX
34	Apoptosis and survival TNFR1 signaling pathway10	9.6	DIABLO, TNFRSF1A, CASP8, TNF, CASP9, CYCS
35	Apoptosis Signaling Pathways37	9.4	CASP8, CASP3, BAX, CASP9, AIFM1, CYCS
36	Antioxidant Action of Vitamin-C36	INF	BDNF, BAX, , FGF2, MYO1F, MYO1C
37	Pathways in cancer20	INF	CYCS, NOS2, COL4A5, EGFR, HGF, HIF1A
38	ILK Signaling36	INF	MYH9, , EPHA2, COL11A2, HGF,
39	Actin Nucleation by ARP-WASP Complex36	INF	ITGB3, FGFR2, ITGA3, ITGA1, MYO3A, MYO1F
40	Fc-GammaR-Mediated Phagocytosis in Macrophages36	INF	MYO1C, MYO6, MYO15A, MYO1A, MYO1F, MYO3A
41	RhoA Pathway36	INF	ITGA3, ITGB3, MYO1C, MYH9, ACTG1, ITGA1
42	Apoptosis and survival Regulation of Apoptosis by Mitochondrial Proteins10	INF	AIFM1, DIABLO, , CYCS, BAX, CASP8
43	MAPK Signaling36	INF	EGFR, LTA, , COL2A1, PRKCH, HGF
44	Transendothelial Migration of Leukocytes36	INF	COL1A1, ITGA3, ITGB3, F2, MYH9, PRKCH
45	Apoptosis and survival_Regulation of Apoptosis by Mitochondrial Proteins41	INF	CASP8, CASP9, DIABLO, BAX, CYCS, AIFM1
46	Influenza A20	INF	HSPA1A, IL1A, ACTG1, , NLRP3, CYCS
47	Molecular Mechanisms of Cancer36	INF	, BAX, ITGA1, , FGF2, FGFR2
48	Apoptosis through Death Receptors36	INF	TNFRSF1A, TNF, CASP9, CASP8, CYCS,
49	RhoGDI Pathway36	INF	FGFR3, EGFR, FGF2, MYO1C, MYO6, MYO15A
50	FAK1 Signaling36	INF	ITGA3, ITGA1, , COL2A1, COL11A1, ITGB3

Compounds related to hearing loss according to GeneDecks:

(show top 50)    (show all 397)

id	Compound	Score	Top Affiliating Genes
1	h2o232	INF	BDNF, XDH, FGFR2, , APOE, MAPK8
2	actinomycin d32	INF	SETD2, SERPINE1, BDNF, BAX, FGF2, IL1A
3	serine32	INF	LRP2, RDX, BTD, SERPINC1, SERPINB6, SETD2
4	creatinine32	INF	SGCA, SERPINC1, BDNF, MTHFR, MTR, MPZ
5	vegf32	INF	SERPINC1, SETD2, SERPINE1, BDNF, BAX, CD36
6	cysteine32	INF	COCH, BTD, PAX3, KCNQ1, LHX3, MTHFR
7	dexamethasone32 42 34 9 9	INF	SERPINC1, SERPINE1, UGT1A1, CD36, CDH1, ITGA1
8	aspartate32	INF	BDNF, UGT2B15, ATP7A, ATP7B, MPZ, CDH1
9	lactate32	INF	BTD, SETD2, BDNF, MT-ND1, XDH, CDH1
10	aldosterone 18-glucuronide32 18	12.0	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6
11	estradiol32 9 18 9	13.9	SERPINE1, BDNF, UGT1A1, UGT1A10, UGT1A3, UGT1A4
12	codeine32 34 9 18 9	14.9	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6
13	bilirubin diglucuronide32 18	11.9	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6
14	cotinine32 18	11.8	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A6, UGT1A7
15	androsterone glucuronide32 18	11.8	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6
16	etiocholanolone32 18	11.8	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6
17	nicotine32 34 9 9	13.8	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A6, UGT1A7
18	estrone32 9 18 9	13.7	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6
19	(23S)-23,25-dihdroxy-24-oxovitamine D3 23-(beta-glucuronide)18	10.7	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6
20	3-alpha-androstanediol glucuronide32 18	11.6	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6
21	Estriol9 18 9	12.5	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6
22	nadph32 18	11.5	FMO1, FMO2, FMO3, FMO4, FMO5, FMO6P
23	ethyl glucuronide32 18	11.4	UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A6, UGT1A7
24	n acetylcysteine32	10.3	SERPINC1, SETD2, BDNF, CDH1, FGFR2, APOE
25	methotrexate32 34 42 9 9	13.9	SERPINE1, CLCN6, MTHFR, MTR, CDH1, GSR
26	folate32	9.9	LRP2, SERPINC1, MTHFR, MTR, CDH1, GSR
27	2-methoxyestradiol32 18	10.8	SETD2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5
28	betacarotene32	9.8	MTHFR, CD36, GSR, GSTM1, APOE, APOH
29	superoxide32 18	9.6	SETD2, MTR, XDH, ATP7A, ATP7B, GUSB
30	pdtc32	8.5	SETD2, XDH, IL1A, MAPK8, F3, CASP3
31	doxorubicin32 34 9 9	11.4	SETD2, BDNF, CDH1, GUSB, GSR, GSTT1
32	sb 20358032 42	9.4	SETD2, CD36, CDH1, FGF2, HSPA4, CASP3
33	quercetin32 42 9 18 9	12.2	UGT1A1, UGT1A3, UGT1A9, BAX, XDH, GUSB
34	paclitaxel32 34 9 9	11.2	SETD2, BDNF, BAX, CDH1, GSN, FGF2
35	curcumin32	7.9	UGT1A1, UGT1A10, UGT1A7, BAX, MPZ, CDH1
36	tamoxifen32 34 9 9	INF	SERPINC1, BDNF, UGT1A1, UGT1A3, UGT1A4, UGT1A6
37	valine32	INF	, BDNF, SCN4A, MT-ND5, MTHFR, MT-ND1
38	rotenone32	INF	MT-ND1, MT-ND6, XDH, GSR, IL1A, MAPK8
39	alanine32	INF	BTD, SERPINC1, UGT1A1, MT-ND5, MT-ND1, MT-ND6
40	ascorbic acid32 18	INF	SETD2, BDNF, CD36, GSTM1, GSTT1, IL1A
41	cycloheximide32	INF	SETD2, SERPINE1, PAX3, BDNF, UGT2B15, BAX
42	oxygen32 18	INF	SETD2, MYO1A, BDNF, SDHD, BAX,
43	vitamin d32	INF	LRP2, , SERPINE1, MTHFR, CD36, CDH1
44	glutamate32	INF	MTHFR, MTR, MPZ, CDH1, FMN1, MITF
45	retinoic acid32 42 18	INF	LRP2, SETD2, SERPINE1, BDNF, UGT1A1, UGT1A10
46	genistein32 9 18 9	INF	SETD2, SERPINE1, UGT1A1, BAX, CD36, CDH1
47	alpha tocopherol32	INF	MTHFR, XDH, CD36, GSR, GSTM1,
48	testosterone32 9 18 9	INF	SERPINC1, SETD2, BDNF, UGT1A1, UGT1A10, UGT1A3
49	arginine32	INF	BTD, SERPINC1, KCNE1, KCNQ1, SCN4A, UGT1A1
50	estrogen32	INF	, RDX, SERPINC1, SETD2, SERPINE1, BDNF

Cellular components related to hearing loss according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	endoplasmic reticulum membrane	GO:005789	INF	UGT1A9, UGT2B11, UGT2B15, UGT2B28, UGT2B7, BAX
2	extracellular region	GO:005576	INF	FAM3C, FGF2, IFNA2, FAM3D, FGFR2, IL1A
3	connexon complex	GO:005922	11.3	GJB6, GJB5, GJB1, GJB2, GJA1, GJB3
4	filamentous actin	GO:031941	11.2	MYO3A, MYO1C, MYO6, MYO1A, MYO1F, ESPN
5	apical plasma membrane	GO:016324	11.2	USH2A, MYO7A, MYO1A, LRP2, KCNE1, CYP4A11
6	basolateral plasma membrane	GO:016323	10.9	KCNQ1, MYO1A, KCNJ10, ATP6V1B1, ATP7A, ATP7B
7	stereocilium	GO:032420	INF	DFNB31, MYO15A, MYO7A, USH1C, CDH23,
8	cytosol	GO:005829	INF	PRPS1, PRKCH, DPYD, , HIF1A, G6PD
9	cell surface	GO:009986	INF	HPN, TNF, STRC, CORIN, PLAT, TNFRSF1A
10	extracellular space	GO:005615	INF	AGT, EGFR, LTA, NGF, COL2A1, TTR
11	endoplasmic reticulum lumen	GO:005788	INF	COL11A1, COL11A2, NGF, FMO1, FKBP14,
12	integral to membrane	GO:016021	INF	UGT1A4, UGT1A9, UGT1A8, UGT1A7, UGT1A6, UGT1A5

Biological processes related to hearing loss according to GeneDecks:

(show all 37)

id	Name	GO ID	Score	Top Affiliating Genes
1	mesenchymal to epithelial transition involved in metanephros morphogenesis	GO:003337	INF	, GREM1, GDNF,
2	visual perception	GO:007601	INF	KCNJ10, , MYO7A, EYA4, COL2A1, CYP1B1
3	positive regulation of epithelial cell proliferation	GO:050679	INF	DLX6, DLX5, EYA1, FGFR2, NOG,
4	branching involved in ureteric bud morphogenesis	GO:001658	INF	GDNF, SIX1, EYA1, GREM1, FGF2,
5	inner ear receptor stereocilium organization	GO:060122	INF	DFNB31, GPR98, ,
6	response to hypoxia	GO:001666	INF	SLC6A4, TNFRSF1A, LTA, IL1A, CAT, PDE5A
7	skeletal system development	GO:001501	INF	COL1A1, COL11A2, NOG, DLX6, DLX5, ANKH
8	pituitary gland development	GO:021983	INF	, SOX2, NOG, , CDH1, LHX3
9	sensory perception of light stimulus	GO:050953	11.5	USH1C, PCDH15, MYO7A, DFNB31, GPR98, CDH23
10	detection of mechanical stimulus involved in sensory perception of sound	GO:050910	11.2	HPN, SLC12A2, SOX2, GPR98, STRC, ATP2B2
11	metabolic process	GO:008152	11.1	UGT2B28, UGT1A10, UGT1A3, UGT1A5, UGT1A6, UGT1A9
12	auditory receptor cell stereocilium organization	GO:060088	11.1	MYO7A, LHFPL5, SOD1, ATP2B2, STRC
13	collagen fibril organization	GO:030199	11.1	ATP7A, COL1A1, COL1A2, COL11A1, COL2A1, COL11A2
14	equilibrioception	GO:050957	11.0	PCDH15, MYO7A, USH1C, CDH23
15	cellular glucuronidation	GO:052695	10.9	UGT1A10, UGT2A1, UGT2B15, UGT2B4, UGT2B7
16	flavonoid glucuronidation	GO:052696	10.9	UGT1A3, UGT1A1, UGT1A7, UGT1A9, UGT1A8
17	flavone metabolic process	GO:051552	10.9	UGT1A7, UGT1A8, UGT1A9, UGT1A10, UGT1A1
18	xenobiotic glucuronidation	GO:052697	10.9	UGT1A1, UGT1A7, UGT1A8, UGT1A9, UGT1A3
19	xenobiotic metabolic process	GO:006805	10.9	ADH1C, ADH7, FMO1, FMO2, CYP4A11, UGT2B15
20	retinoic acid metabolic process	GO:042573	10.9	UGT1A7, UGT1A9, ADH7, UGT1A3, UGT1A1, UGT1A8
21	ethanol oxidation	GO:006069	10.7	ADH7, ADH1C, ADH5, ADH4, ADH1B
22	estrogen metabolic process	GO:008210	10.6	COMT, HSD17B4, UGT2B11, UGT1A1, CYP1B1, SULT1E1
23	drug metabolic process	GO:017144	10.2	UGT1A9, UGT1A8, UGT1A7, FMO3, UGT1A1, FMO2
24	negative regulation of neuron apoptotic process	GO:043524	10.2	GDNF, BAX, HIF1A, BDNF, AGT, SOD1
25	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	GO:008635	10.0	CASP3, CASP9, DIABLO, CYCS, BAX
26	activation of cysteine-type endopeptidase activity involved in apoptotic process	GO:006919	9.9	PPARG, NLRP3, TNF, AIFM1, CASP8, F3
27	extracellular matrix organization	GO:030198	INF	COL11A2, , COL1A1, COL4A5, , COL1A2
28	response to lipopolysaccharide	GO:032496	INF	COMT, F3, , ABCC5, LTA, PDE5A
29	small molecule metabolic process	GO:044281	INF	CDA, CD36, MTR, XDH, MTHFR, AGT
30	positive regulation of transcription from RNA polymerase II promoter	GO:045944	INF	FOXC1, NOS1, PITX2, HIF1A, LHX3, SOX2
31	positive regulation of branching involved in ureteric bud morphogenesis	GO:090190	INF	NOG, GREM1, GDNF, SIX1, , AGT
32	inner ear morphogenesis	GO:042472	INF	ATP6V1B1, SIX1, POU4F3, SOX2, COL2A1, DLX6
33	sensory perception of sound	GO:007605	INF	SLC26A5, SLC52A3, SLC26A4, POU4F3, POU3F4, SOD1
34	blood coagulation	GO:007596	INF	SLC16A1, SOD1, PROCR, PRKCH, PDE5A,
35	negative regulation of apoptotic process	GO:043066	INF	WFS1, NOG, , SOD2, EGFR, COL2A1
36	cochlea morphogenesis	GO:090103	INF	POU3F4, , EYA1, HPN, HOXA1, SIX1
37	axon guidance	GO:007411	INF	COL2A1, COL9A3, COL1A2, , COL4A5, COL1A1

Molecular functions related to hearing loss according to GeneDecks:

(show all 17)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein homodimerization activity	GO:042803	INF	DPYD, , ADH7, SLC6A4, PON1, SOD1
2	extracellular matrix structural constituent conferring tensile strength	GO:030020	INF	, COL9A3, COL2A1, , COL11A2
3	enzyme binding	GO:019899	INF	PPARG, EGFR, HIF1A, PRKCH, UGT1A4, PTGS2
4	protein binding	GO:005515	INF	TTR, , TFB1M, DNMT1, , DFNB31
5	iron ion binding	GO:005506	INF	CYP4B1, NOS1, CYP20A1, , SDHD, XDH
6	glucuronosyltransferase activity	GO:015020	11.1	UGT1A8, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7
7	protease binding	GO:002020	11.1	C10orf2, POLG, TNFRSF1A, TNF, HSPA1B, F3
8	gap junction channel activity	GO:005243	11.0	GJA1, GJD2, GJB4, GJB3, GJB2, GJB1
9	retinoic acid binding	GO:001972	10.9	UGT1A6, UGT1A4, UGT1A3, UGT1A10, UGT1A7, UGT1A8
10	N,N-dimethylaniline monooxygenase activity	GO:004499	10.8	FMO5, FMO3, FMO2, FMO1, FMO4
11	calmodulin binding	GO:005516	10.5	NOS2, NOS1, TRPV1, ATP2B2, KCNQ1, MYH9
12	protein heterodimerization activity	GO:046982	10.2	UGT1A1, UGT1A3, UGT1A4, UGT1A10, UGT1A6, UGT1A7
13	NADP binding	GO:050661	10.0	FMO5, NOS2, FMO1, FMO2, FMO4, GSR
14	flavin adenine dinucleotide binding	GO:050660	10.0	FMO2, NOS1, DPYD, NOS2, AIFM1, FMO1
15	heme binding	GO:020037	9.2	CYP8B1, CYP4B1, CYP20A1, NOS1, CYP1B1, CYP4A11
16	electron carrier activity	GO:009055	INF	CYP8B1, ALDH4A1, SDHD, CYP4A11, CYP1B1, GSR
17	identical protein binding	GO:042802	INF	ACTG1, KCNJ10, CLDN23, BAX, ITGB3, EGFR