Heart Lymphoma

Categories: Cancer diseases, Immune diseases, Cardiovascular diseases

Aliases & Classifications for Heart Lymphoma

MalaCards integrated aliases for Heart Lymphoma:

Name: Heart Lymphoma 12 14
Lymphoma of Heart 12
Cardiac Lymphoma 69


External Ids:

Disease Ontology 12 DOID:6547
NCIt 47 C5368
UMLS 69 C1332850

Summaries for Heart Lymphoma

MalaCards based summary : Heart Lymphoma, also known as lymphoma of heart, is related to blake pouch cyst and angiomatosis, diffuse corticomeningeal, of divry and van bogaert. An important gene associated with Heart Lymphoma is HLA-DRA (Major Histocompatibility Complex, Class II, DR Alpha), and among its related pathways/superpathways are ICos-ICosL Pathway in T-Helper Cell and B cell receptor signaling pathway (KEGG). The drugs Bleomycin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include heart, b cells and t cells, and related phenotype is liver/biliary system.

Related Diseases for Heart Lymphoma

Graphical network of the top 20 diseases related to Heart Lymphoma:

Diseases related to Heart Lymphoma

Symptoms & Phenotypes for Heart Lymphoma

MGI Mouse Phenotypes related to Heart Lymphoma:

id Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 8.8 BCL6 MME PTPRC

Drugs & Therapeutics for Heart Lymphoma

Drugs for Heart Lymphoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 297)
id Name Status Phase Clinical Trials Cas Number PubChem Id
Bleomycin Approved Phase 4,Phase 3,Phase 2 11056-06-7 5360373
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
Dacarbazine Approved, Investigational Phase 4,Phase 3,Phase 2 4342-03-4 5351166
Doxorubicin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 23214-92-8 31703
Etoposide Approved Phase 4,Phase 3,Phase 2,Phase 1 33419-42-0 36462
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1 174722-31-7 10201696
Vincristine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
Epirubicin Approved Phase 4,Phase 3 56420-45-2 41867
Liraglutide Approved Phase 4 204656-20-2 44147092
Doxil Approved June 1999 Phase 4,Phase 3,Phase 2,Phase 1 31703
Angiotensin II Investigational Phase 4 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
13 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
14 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Phase 1
15 Etoposide phosphate Phase 4,Phase 3,Phase 2,Phase 1
16 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
17 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
18 Hormones Phase 4,Phase 3,Phase 2,Phase 1
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
20 Angiotensin II Type 1 Receptor Blockers Phase 4
21 Angiotensin Receptor Antagonists Phase 4
22 Angiotensinogen Phase 4
23 Antihypertensive Agents Phase 4,Phase 3
24 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
25 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
26 Hypoglycemic Agents Phase 4,Phase 2
27 Incretins Phase 4,Phase 2
28 glucagon Phase 4
29 Glucagon-Like Peptide 1 Phase 4
Mechlorethamine Approved Phase 3,Phase 2 51-75-2 4033
Prednisone Approved, Vet_approved Phase 3,Phase 2,Phase 1 53-03-2 5865
Vinblastine Approved Phase 3,Phase 2 865-21-4 13342 241903
Lenalidomide Approved Phase 3,Phase 2,Phase 1 191732-72-6 216326
Bortezomib Approved, Investigational Phase 3,Phase 2,Phase 1 179324-69-7 387447 93860
Methylprednisolone Approved, Vet_approved Phase 3,Phase 2 83-43-2 6741
Prednisolone Approved, Vet_approved Phase 3,Phase 2 50-24-8 5755
Asparaginase Approved Phase 3,Phase 2 9015-68-3
Cytarabine Approved, Investigational Phase 3,Phase 2,Phase 1 147-94-4 6253
Hydrocortisone Approved, Vet_approved Phase 3,Phase 2 50-23-7 5754 657311
Levoleucovorin Approved Phase 3,Phase 2 68538-85-2
Methotrexate Approved Phase 3,Phase 2,Phase 1 1959-05-2, 59-05-2 126941
Carmustine Approved Phase 3,Phase 2,Phase 1 154-93-8 2578
Melphalan Approved Phase 3,Phase 2 148-82-3 4053 460612
Erythromycin Approved, Vet_approved Phase 3 114-07-8 12560
Lenograstim Approved Phase 3,Phase 2,Phase 1 135968-09-1
Pentamidine Approved Phase 3 100-33-4 4735
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3, Phase 1 22916-47-8 4189
Carvedilol Approved, Investigational Phase 3 72956-09-3 2585
Enalapril Approved, Vet_approved Phase 3 75847-73-3 5362032 40466924
Enalaprilat Approved Phase 3 76420-72-9 6917719

Interventional clinical trials:

(show top 50) (show all 221)

id Name Status NCT ID Phase Drugs
1 Prevention of CHOP-induced Chronic Cardiotoxicity Completed NCT00162955 Phase 4 Valsartan
2 Clinical Application of Polyethylene Glycol Liposome Doxorubicin (PLD) in Primary Lymphoma Recruiting NCT02526823 Phase 4 R-CHOP/CHOPE or ABVD chemotherapy regimen;R-CDOP/CDOPE or DBVD chemotherapy regimen
3 Antigen-Lipid-Driven Monoclonal Gammopathies Targeting Epicardial Fat Not yet recruiting NCT02920190 Phase 4 Liraglutide
4 Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Hodgkin's Lymphoma Unknown status NCT00003389 Phase 3 Doxorubicin;Bleomycin;Vinblastine;Dacarbazine;Vincristine;Mechlorethamine;Etoposide;Prednisone;Cyclophosphamide
5 Exercise During Chemotherapy for Patients With Hematological Malignancies Unknown status NCT00884364 Phase 3
6 Comparison Study of Doxorubicin Versus Epirubicin-induced Cardiotoxicity in Patients With DLBCL Completed NCT00854568 Phase 3 CEOP regimen;CHOP regimen
7 Combination Chemotherapy in Treating Patients With Acute Lymphoblastic Leukemia or Advanced Lymphoblastic Non-Hodgkin's Lymphoma Completed NCT01230983 Phase 3 asparaginase;cytarabine;dexrazoxane hydrochloride;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;prednisone;therapeutic hydrocortisone;vincristine sulfate
8 Rituxan vs Bexxar When Combined With Carmustine, Etoposide, Cytarabine and Melphalan (BEAM) With Autologous Hematopoietic Stem Cell Transplantation (BMT CTN 0401) Completed NCT00329030 Phase 3 Autologous transplantation using rituxan/BEAM;Autologous transplantation using Bexxar/BEAM
9 Study to Assess the Effect of Treatment With Bendamustine in Combination With Rituximab on QT Interval in Patients With Advanced Indolent Non-Hodgkin's Lymphoma (NHL) or Mantle Cell Lymphoma (MCL) Completed NCT01073163 Phase 3 Bendamustine;Rituximab
10 Chemotherapy Followed by Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin's Disease Completed NCT00002827 Phase 3 dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;vincristine sulfate
11 Combination Chemotherapy With or Without Dexrazoxane in Treating Children With Hodgkin's Disease Completed NCT00005578 Phase 3 cyclophosphamide;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;prednisone;vincristine sulfate
12 Bone Marrow Transplantation in Treating Patients With Leukemia, Myelodysplasia, or Lymphoblastic Lymphoma Completed NCT00003187 Phase 2, Phase 3 cyclophosphamide;cyclosporine;cytarabine;methotrexate;methylprednisolone
13 Treatment of Disseminated High Grade Lymphoma Completed NCT00536393 Phase 2, Phase 3 Doxorubicin;Doxorubicin pegylated
14 Prevention of Left Ventricular Dysfunction During Chemotherapy Completed NCT01110824 Phase 3 Enalapril and carvedilol
15 Comparison of Two Combination Chemotherapy Regimens With Either Vincristine or Vinblastine in Treating Patients With Advanced Anaplastic Large Cell Lymphoma Completed NCT00059839 Phase 3 doxorubicin hydrochloride;mercaptopurine;methotrexate;prednisone;vinblastine sulfate;vincristine sulfate
16 Combination Chemotherapy and Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin Lymphoma Completed NCT01026220 Phase 3 doxorubicin hydrochloride;liposomal vincristine sulfate;vinorelbine tartrate;cyclophosphamide;etoposide phosphate;prednisone;ifosfamide
17 Total-Body Irradiation With or Without Fludarabine Phosphate Followed By Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer Completed NCT00075478 Phase 3 Fludarabine Phosphate;Mycophenolate Mofetil;Cyclosporine
18 Comparison of Fluconazole vs Voriconazole to Treat Fungal Infections for Blood and Marrow Transplants (BMT CTN 0101) Completed NCT00075803 Phase 3 Fluconazole;Voriconazole
19 R-CHOP Versus R-CDOP as First-line Treatment for Elderly Patients With Diffuse Large-B-cell Lymphoma Recruiting NCT02428751 Phase 3 Pegylated liposomal doxorubicin;Doxorubicin;Rituximab;Cyclophophamide;Vincristine;Prednisone
20 Lenalidomide Plus Rituximab Followed by Lenalidomide Versus Rituximab Maintenance for Relapsed/Refractory Follicular, Marginal Zone or Mantle Cell Lymphoma. Recruiting NCT01996865 Phase 3 Lenalidomide;Rituximab
21 A Study Of PF-05280586 (Rituximab-Pfizer) Or MabThera® (Rituximab-EU) For The First-Line Treatment Of Patients With CD20-Positive, Low Tumor Burden, Follicular Lymphoma (REFLECTIONS B328-06) Recruiting NCT02213263 Phase 3
22 Safety and Efficacy Study of BCD-020 in Therapy of Non-Hodgkin's Lymphoma Recruiting NCT01701232 Phase 3
23 Ibrutinib Before and After Stem Cell Transplant in Treating Patients With Relapsed or Refractory Diffuse Large B-cell Lymphoma Recruiting NCT02443077 Phase 3 Carmustine;Cyclophosphamide;Cytarabine;Etoposide;Ibrutinib;Melphalan
24 Combination Chemotherapy With or Without Bortezomib in Treating Younger Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or Stage II-IV T-Cell Lymphoblastic Lymphoma Recruiting NCT02112916 Phase 3 Bortezomib;Cyclophosphamide;Cytarabine;Daunorubicin Hydrochloride;Dexamethasone;Doxorubicin Hydrochloride;Etoposide;Hydrocortisone Sodium Succinate;Ifosfamide;Leucovorin Calcium;Mercaptopurine;Methotrexate;Pegaspargase;Thioguanine;Vincristine Sulfate
25 Brentuximab Vedotin and Combination Chemotherapy in Treating Children and Young Adults With Stage IIB or Stage IIIB-IVB Hodgkin Lymphoma Recruiting NCT02166463 Phase 3 Brentuximab Vedotin;Cyclophosphamide;Doxorubicin Hydrochloride;Etoposide;Prednisone;Vincristine Sulfate
26 Plerixafor Versus G-CSF in the Treatment of People With WHIM Syndrome Recruiting NCT02231879 Phase 3 Plerixafor;G-CSF
27 Risk-Adapted Chemotherapy in Treating Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia or Localized B-Lineage Lymphoblastic Lymphoma Recruiting NCT01190930 Phase 3 Cyclophosphamide;Cytarabine;Dexamethasone;Doxorubicin Hydrochloride;Leucovorin Calcium;Mercaptopurine;Methotrexate;Pegaspargase;Thioguanine;Vincristine Sulfate
28 Crizotinib in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Removed by Surgery and ALK Fusion Mutations (An ALCHEMIST Treatment Trial) Recruiting NCT02201992 Phase 3 Crizotinib
29 A Study of the Safety and Effectiveness of Apixaban in Preventing Blood Clots in Children With Leukemia Who Have a Central Venous Catheter and Are Treated With Pegylated (PEG) L-Asparaginase Recruiting NCT02369653 Phase 3 Apixaban
30 Double Cord Versus Haploidentical (BMT CTN 1101) Recruiting NCT01597778 Phase 3
31 A Long-term Extension Study of PCI-32765 (Ibrutinib) Recruiting NCT01804686 Phase 3 PCI-32765 (Ibrutinib)
32 A Study Of Lorlatinib Versus Crizotinib In First Line Treatment Of Patients With ALK-Positive NSCLC Recruiting NCT03052608 Phase 3 Lorlatinib;Crizotinib
33 R-ABVD vs ABVD-RT in Early Stage Hodgkin's Lymphoma Active, not recruiting NCT00992030 Phase 3 Rituximab
34 Combination Chemotx in Treating Children or Adolescents With Newly Diagnosed Stg III or Stg IV Lymphoblastic Lymphoma Active, not recruiting NCT00004228 Phase 3 asparaginase;cyclophosphamide;cytarabine;daunorubicin hydrochloride;dexamethasone;doxorubicin hydrochloride;leucovorin calcium;mercaptopurine;methotrexate;prednisone;thioguanine;vincristine sulfate
35 Rituximab Plus Lenalidomide for Patients With Relapsed / Refractory Indolent Non-Hodgkin's Lymphoma (Follicular Lymphoma and Marginal Zone Lymphoma) Active, not recruiting NCT01938001 Phase 3 Rituximab;Lenalidomide;Placebo
36 S0016 Combination Chemotherapy With Monoclonal Antibody Therapy in Newly Diagnosed Non-Hodgkin's Lymphoma Active, not recruiting NCT00006721 Phase 3 cyclophosphamide;doxorubicin;prednisone;vincristine
37 Rituximab in Treating Patients With Low Tumor Burden Indolent Non-Hodgkin's Lymphoma Active, not recruiting NCT00075946 Phase 3
38 Ibrutinib and Rituximab Compared With Fludarabine Phosphate, Cyclophosphamide, and Rituximab in Treating Patients With Untreated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Active, not recruiting NCT02048813 Phase 3 Cyclophosphamide;Fludarabine Phosphate;Ibrutinib
39 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic Lymphoma Active, not recruiting NCT00408005 Phase 3 Asparaginase;Cyclophosphamide;Cytarabine;Daunorubicin Hydrochloride;Dexamethasone;Doxorubicin Hydrochloride;Leucovorin Calcium;Mercaptopurine;Methotrexate;Nelarabine;Pegaspargase;Prednisone;Thioguanine;Vincristine Sulfate
40 A Phase 3 Study of Brentuximab Vedotin (SGN-35) in Patients at High Risk of Residual Hodgkin Lymphoma Following Stem Cell Transplant (The AETHERA Trial) Active, not recruiting NCT01100502 Phase 3 brentuximab vedotin;placebo
41 Autologous or Donor Stem Cell Transplantation in Treating Patients With Recurrent Non-Hodgkin's Lymphoma (BMT CTN 0202) Terminated NCT00096460 Phase 2, Phase 3 Cyclophosphamide and Rituximab;Filgrastim;Non-myeloablative Conditioning regimen;Rituximab maintenance therapy;GVHD Prophylaxis
42 Efficacy and Safety of Idelalisib (GS-1101) in Combination With Rituximab for Previously Treated Indolent Non-Hodgkin Lymphomas Terminated NCT01732913 Phase 3 Placebo;Rituximab;Idelalisib
43 Efficacy and Safety of Idelalisib (GS-1101) in Combination With Bendamustine and Rituximab for Previously Treated Indolent Non-Hodgkin Lymphomas Terminated NCT01732926 Phase 3 Idelalisib;Rituximab;Bendamustine;Placebo
44 A Study to Evaluate the Efficacy of Lenalidomide as Maintenance Therapy After Completion of First-line Combination Chemotherapy in Patients With Mantle Cell Lymphoma (MCL). Terminated NCT01021423 Phase 3 Lenalidomide
45 A Dose Study of Doxil in a Dose Dense, 14 Day CDOP/Rituximab Regimen for Patients With Diffuse Large B-Cell Non-Hodgkin Lymphoma (NHL)> 60 Years or With Compromised Cardiac Status. Unknown status NCT00333008 Phase 2 Doxil;Cyclophosphamide;Vincristine;Prednisone;Rituximab;Pegfilgrastim
46 Study With Rituximab, Cyclophosphamide, Doxorubicin Liposomal (Myocet®), Vincristine, Prednisone, (R-COMP) to Treat Non-Hodgkin's Lymphoma Unknown status NCT01009970 Phase 2 Rituximab;Cyclophosphamide;Vincristine;Prednisone;Doxorubicin
47 Bendamustine Hydrochloride and Rituximab With or Without Bortezomib Followed by Rituximab With or Without Lenalidomide in Treating Patients With High-Risk Stage II, Stage III, or Stage IV Follicular Lymphoma Unknown status NCT01216683 Phase 2 bendamustine hydrochloride;bortezomib;lenalidomide
48 MR, Histologic And EM Imaging Of Intravenous Ferumoxytol In Central Nervous System (CNS) Inflammation Unknown status NCT00659776 Phase 2 Ferumoxytol
49 Lenalidomide in Previously Treated Patients With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Completed NCT00439231 Phase 2 Lenalidomide
50 Effects of Anticoagulant Preventive Injection in Patients With Blood Cancer Completed NCT02260414 Phase 2 Tinzaparin

Search NIH Clinical Center for Heart Lymphoma

Genetic Tests for Heart Lymphoma

Anatomical Context for Heart Lymphoma

MalaCards organs/tissues related to Heart Lymphoma:

Heart, B Cells, T Cells, Bone, Bone Marrow, Kidney, Testes

Publications for Heart Lymphoma

Articles related to Heart Lymphoma:

id Title Authors Year
Heart lymphoma 6 years after a prosthetic ascending aorta replacement: related or unrelated? ( 17287694 )

Variations for Heart Lymphoma

Expression for Heart Lymphoma

Search GEO for disease gene expression data for Heart Lymphoma.

Pathways for Heart Lymphoma

GO Terms for Heart Lymphoma

Cellular components related to Heart Lymphoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 secretory granule membrane GO:0030667 8.62 MME PTPRC

Biological processes related to Heart Lymphoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 T cell receptor signaling pathway GO:0050852 8.96 HLA-DRA PTPRC
2 positive regulation of B cell proliferation GO:0030890 8.62 BCL6 PTPRC

Sources for Heart Lymphoma

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
52 Novoseek
55 OMIM via Orphanet
59 PubMed
66 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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