MCID: HRT011
MIFTS: 36

Heart Septal Defect malady

Summaries for Heart Septal Defect

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63Wikipedia, 32MalaCards
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Wikipedia:63 Heart septal defect refers to a congenital heart defect of one of the septa of the heart. more...

MalaCards: Heart Septal Defect, also known as septal defect, is related to tetralogy of fallot and atrial heart septal defect. An important gene associated with Heart Septal Defect is NKX2-5 (NK2 homeobox 5), and among its related pathways is Cardiac Progenitor Differentiation. Affiliated tissues include heart, brain and lung.

Aliases & Classifications for Heart Septal Defect

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH
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Aliases & Descriptions:

heart septal defect 8
septal defect 8 44
congenital septal defect of heart 8
cardiac septal defects 8
heart septal defects 60
septal defect nos 8


External Ids:

Disease Ontology8 DOID:1681
NCIt39 C84482
MeSH34 D006343

Related Diseases for Heart Septal Defect

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17GeneCards, 18GeneDecks
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Diseases related to Heart Septal Defect via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 460)
idRelated DiseaseScoreTop Affiliating Genes
1tetralogy of fallot31.2NKX2-5, MEGF9, IPPK
2atrial heart septal defect30.5MYH6, NKX2-5
3holt-oram syndrome30.4MYH6
4congenital heart defect30.1NKX2-5, MYH6
5noonan syndrome29.8MYH6, NKX2-5
6atrioventricular septal defect11.2
7double outlet right ventricle10.8
8patent ductus arteriosus10.6
9patent foramen ovale10.6
10septal myocardial infarction10.6
11endocarditis10.6
12myocardial infarction10.6
13dextrocardia10.6
14aortic valve prolapse10.5
15pulmonary valve stenosis10.5
16down syndrome10.5
17situs inversus10.4
18infective endocarditis10.4
19dandy-walker like malformation with atrioventricular septal defect10.4
20right bundle branch block10.4
21atrial septal defect 810.4
22acute myocardial infarction10.4
23migraine10.4
24atrial septal defect coronary sinus10.4
25atrioventricular block10.3
26constrictive pericarditis10.3
27pericarditis10.3
28vascular disease10.3
29atrial septal defect sinus venosus10.3
30ventricular septal defect 110.3
31hypertrophic cardiomyopathy10.3
32aortic incompetence10.3
33migraine with aura10.3
34atrial septal defect 610.3
35atrioventricular septal defect 410.3
36lutembacher's syndrome10.3
37polydactyly10.3
38subacute bacterial endocarditis10.3
39pericardial effusion10.3
40subvalvular aortic stenosis10.3
41atrial septal defect ostium primum10.3
42familial pulmonary arterial hypertension leucopenia and atrial septal defect10.3
43tarp syndrome10.3
44pulmonary atresia with ventricular septal defect10.3
45atrial septal defect 510.3
46atrial septal defect 310.3
47ventricular septal defect 310.3
48atrioventricular septal defect 510.3
49thrombocytopenia-absent radius syndrome10.2
50cerebritis10.2

Graphical network of the top 20 diseases related to Heart Septal Defect:



Diseases related to heart septal defect

Clinical Features for Heart Septal Defect

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Drugs & Therapeutics for Heart Septal Defect

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Heart Septal Defect

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Genetic Tests for Heart Septal Defect

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Anatomical Context for Heart Septal Defect

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32MalaCards
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MalaCards organs/tissues related to Heart Septal Defect:

32
Heart, Brain, Lung

Animal Models for Heart Septal Defect or affiliated genes

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Publications for Heart Septal Defect

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50PubMed
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Articles related to Heart Septal Defect:

(show top 50)    (show all 64)
idTitleAuthorsYear
1
Timing in resolution of left heart dilation according to the degree of mitral regurgitation in children with ventricular septal defect after surgical closure. (24140379)
2013
2
Heart failure after transvenous closure of atrial septal defect associated with atrial standstill and thiamine-responsive megaloblastic anemia. (24164997)
2013
3
Perventricular closure on the beating heart: an effective hybrid approach in managing a postinfarction apical ventricular septal defect. (23186161)
2013
4
Use of a totally artificial heart for a complex postinfarction ventricular septal defect. (23803241)
2013
5
'Just-flow' images of the fetal heart: insights into interventricular shunting across a small ventricular septal defect and enhanced visualization of the fetal heart. (22887714)
2013
6
Echocardiographic features defining right dominant unbalanced atrioventricular septal defect: a multi-institutional Congenital Heart Surgeons' Society study. (23784944)
2013
7
Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16. (23708191)
2013
8
The application of on-pump beating-heart surgery for partial atrioventricular septal defect: a report of 87 cases. (24217239)
2013
9
Clinical and pathologic comparison of simple left-to-right shunt congenital heart disease and transposition of the great arteries with ventricular septal defect. (22543345)
2012
10
Gunshot wounds: causing myocardial infarction, delayed ventricular septal defect, and congestive heart failure. (22412248)
2012
11
No escape from a VSD device? Complete heart block and cardiac arrest associated with a ventricular septal defect occluder device. (21851474)
2012
12
Palliative arterial switch operation in the context of multiple ventricular septal defects, potentially biventricular and univentricular hearts with malposed great arteries: a review of 15 cases. (23804860)
2012
13
Risk factors and outcomes of post-procedure heart blocks after transcatheter device closure of perimembranous ventricular septal defect. (22516400)
2012
14
Search of somatic GATA4 and NKX2.5 gene mutations in sporadic septal heart defects. (21276881)
2011
15
Surgical interventions for atrioventricular septal defect subtypes: the pediatric heart network experience. (21872212)
2011
16
Case 5/2011--infant of 17 months of age with tetralogy of fallot in open heart failure due to hemodynamic dominance of the ventricular septal defect. (22030702)
2011
17
Mechanisms of pulmonary hypertension related to ventricular septal defect in congenital heart disease. (22035778)
2011
18
Perventricular device closure of post-myocardial infarction ventricular septal defect on the beating heart. (21247590)
2011
19
Echocardiographic diagnosis of atrioventricular septal defect without primum atrial septal defect: a relatively "common" congenital heart defect in Down's syndrome. (21362598)
2011
20
Repair of massive ventricular septal defect with tricuspid straddling under mild hypothermia cardiopulmonary bypass with beating heart. (19157607)
2010
21
Echocardiographic definition and surgical decision-making in unbalanced atrioventricular septal defect: a Congenital Heart Surgeons' Society multiinstitutional study. (20837915)
2010
22
B-type natriuretic peptide and heart failure in patients with ventricular septal defect: a pilot study. (19636481)
2009
23
Deleterious effect of unintentional pacing from the middle cardiac vein in a patient with congenitally corrected transposition of the great arteries and ventricular septal defect. The beneficial effect of cardiac resynchronization therapy after heart surgery. (18758930)
2009
24
Genetic screening of 104 patients with congenitally malformed hearts revealed a fresh mutation of GATA4 in those with atrial septal defects. (19678963)
2009
25
Heart-lung transplantation in patients with pulmonary atresia and ventricular septal defect. (19698864)
2009
26
Pulmonary arterial hypertension in adults born with a heart septal defect: the Euro Heart Survey on adult congenital heart disease. (17164490)
2007
27
Diagnostic value of plasma concentration of pro-brain natriuretic peptide in congestive heart failure in pediatric patients with ventricular septal defects]. (15833183)
2005
28
Hypoplastic left heart syndrome with restrictive atrial septal defect: influence on cardiac transplantation. (15493071)
2004
29
Prevalence and prognosis of atrial septal aneurysm in high risk fetuses without structural heart defects. (12066564)
2002
30
Growth parameters and endocrine function in relation to echocardiographic parameters in children with ventricular septal defect without heart failure. (11419677)
2001
31
Modified Rastelli using an autograft: A new concept for correction of transposition of the great arteries with ventricular septal defect and left ventricular outflow tract obstruction (with an extension to other congenital heart defects). (11486190)
2000
32
Partial atrioventricular septal defect causing confusion with rheumatic heart disease in children in Harare--case reports. (10746401)
1999
33
Eisenmenger syndrome in adults: ventricular septal defect, truncus arteriosus, univentricular heart. (10400015)
1999
34
Congenital cataract, microphthalmia and septal heart defect in two generations: a new syndrome? (8281271)
1993
35
Acyanotic congenital heart disease. Atrial and ventricular septal defects, atrioventricular canal, patent ductus arteriosus, pulmonic stenosis. (8252562)
1993
36
Unique variant of Taussig-Bing heart: double-outlet right ventricle with double ventricular septal defects and double overriding of great arteries. (1866333)
1991
37
Right-sided heart with mirror-image atrial arrangement, complete transposition, ventricular septal defect and subpulmonary stenosis. (2914748)
1989
38
Left atrial isomerism combined with right-sided heart, common atrium, incomplete atrioventricular septal defect and partial anomalous systemic and pulmonary venous drainage. Report of a case with successful surgical correction. (3397202)
1988
39
An easy and safe technique for ventricular septal defect closure in hearts with atrioventricular discordant connection and dextrocardia. (3675063)
1987
40
Long-term management of bradyarrhythmias following open heart surgery: surgical A-V block and sick sinus syndrome after surgery for secundum atrial septal defects treated with permanent cardiac pacing. (3099026)
1986
41
Heart block and atrioventricular septal defect. (2417374)
1985
42
Balloon occlusion of atrial septal defect to assess right ventricular capability in hypoplastic right heart syndrome. (6225563)
1983
43
Persistent Eustachian valve causing severe cyanosis in atrial septal defect with normal right heart pressures. (6824197)
1983
44
Criss-cross heart--a case with horizontal septum, complete transposition, pulmonary atresia and ventricular septal defect. (7163021)
1982
45
Palliative repair of transposition of the great arteries with criss-cross heart: ventricular septal defect and hypoplastic right (systemic) ventricle. (6176816)
1982
46
Open-heart palliative surgery for pulmonary atresia with ventricular septal defect and hypoplastic pulmonary arteries. (83013)
1978
47
The conduction system in double outlet right ventricle with subpulmonic ventricular septal defect and related hearts (the Taussig-Bing group). (947575)
1976
48
Rheumatic heart disease associated with atrial septal defect: clinical and pathologic study of 12 cases of Lutembacher's syndrome. (13617192)
1959
49
Pure ventricular septal defect and ventricular septal defect with pulmonic stenosis; hemodynamic and clinical changes following open heart surgery. (13670116)
1959
50
CONGENITAL HEART BLOCK WITH ATRIAL AND VENTRICULAR SEPTAL DEFECT. (18609914)
1943

Genetic Variations for Heart Septal Defect

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Expression for genes affiliated with Heart Septal Defect

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Heart Septal Defect

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Pathways for genes affiliated with Heart Septal Defect

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37NCBI BioSystems Database
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Pathways related to Heart Septal Defect according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6MYH6, NKX2-5

Compounds for genes affiliated with Heart Septal Defect

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GO Terms for genes affiliated with Heart Septal Defect

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16Gene Ontology
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Biological processes related to Heart Septal Defect according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1adult heart developmentGO:0075129.6MYH6, NKX2-5
2canonical Wnt receptor signaling pathwayGO:0600709.6MYH6, NKX2-5
3sarcomere organizationGO:0452149.5MYH6, NKX2-5
4BMP signaling pathwayGO:0305099.3MYH6, NKX2-5

Products for genes affiliated with Heart Septal Defect

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Sources for Heart Septal Defect

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet