MCID: HRT011
MIFTS: 33

Heart Septal Defect malady

Summaries for Heart Septal Defect

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64Wikipedia, 33MalaCards
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Wikipedia:64 Heart septal defect refers to a congenital heart defect of one of the septa of the heart. more...

MalaCards: Heart Septal Defect, also known as septal defect, is related to atrial heart septal defect and holt-oram syndrome. An important gene associated with Heart Septal Defect is NKX2-5 (NK2 homeobox 5), and among its related pathways is Cardiac Progenitor Differentiation.

Aliases & Classifications for Heart Septal Defect

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH
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Aliases & Descriptions:

heart septal defect 8
septal defect 8 45
congenital septal defect of heart 8
cardiac septal defects 8
heart septal defects 61
septal defect nos 8


External Ids:

Disease Ontology8 DOID:1681
NCIt40 C84482
MeSH35 D006343

Related Diseases for Heart Septal Defect

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Heart Septal Defect via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 470)
idRelated DiseaseScoreTop Affiliating Genes
1atrial heart septal defect30.6MYH6, NKX2-5
2holt-oram syndrome30.4MYH6
3tetralogy of fallot30.2MEGF9, NKX2-5, IPPK
4noonan syndrome29.8NKX2-5, MYH6
5atrioventricular septal defect11.2
6multiple ventricular septal defects10.7
7left ventricular outflow tract obstruction10.7
8patent ductus arteriosus10.7
9patent foramen ovale10.6
10septal myocardial infarction10.6
11tricuspid atresia10.6
12pulmonic stenosis10.6
13dextrocardia10.6
14eisenmenger syndrome10.6
15aortic valve prolapse10.5
16aortic coarctation10.5
17atrial septal aneurysm10.5
18down syndrome10.5
19aortopulmonary window10.5
20situs inversus10.5
21atrial septal defect sinus venosus10.5
22ventricular septal defect 210.5
23n syndrome10.4
24atrial septal defect ostium primum10.4
25dandy-walker like malformation with atrioventricular septal defect10.4
26single ventricular septal defect10.4
27double outlet left ventricle10.4
28cleft mitral valve10.4
29atrial septal defect coronary sinus10.4
30ventricular septal defect 110.4
31acute myocardial infarction10.4
32atrioventricular block10.3
33constrictive pericarditis10.3
34vascular disease10.3
35subpulmonary stenosis10.3
36ventricular septal defect 310.3
37double-orifice mitral valve10.3
38lutembacher's syndrome10.3
39hypertrophic cardiomyopathy10.3
40aortic incompetence10.3
41aortic arch interruption10.3
42atrial septal defect 810.3
43atrioventricular septal defect 410.3
44pulmonary artery hypoplasia10.3
45polydactyly10.3
46subacute bacterial endocarditis10.3
47subvalvular aortic stenosis10.3
48familial pulmonary arterial hypertension leucopenia and atrial septal defect10.3
49heterotaxy10.3
50tarp syndrome10.3

Graphical network of the top 20 diseases related to Heart Septal Defect:



Diseases related to heart septal defect

Clinical Features for Heart Septal Defect

Drugs & Therapeutics for Heart Septal Defect

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Heart Septal Defect

Search NIH Clinical Center for Heart Septal Defect

Search CenterWatch for Heart Septal Defect

Genetic Tests for Heart Septal Defect

Anatomical Context for Heart Septal Defect

Animal Models for Heart Septal Defect or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Heart Septal Defect

Sources:
51PubMed
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Articles related to Heart Septal Defect:

(show top 50)    (show all 64)
idTitleAuthorsYear
1
Timing in resolution of left heart dilation according to the degree of mitral regurgitation in children with ventricular septal defect after surgical closure. (24140379)
2013
2
Heart failure after transvenous closure of atrial septal defect associated with atrial standstill and thiamine-responsive megaloblastic anemia. (24164997)
2013
3
Perventricular closure on the beating heart: an effective hybrid approach in managing a postinfarction apical ventricular septal defect. (23186161)
2013
4
Use of a totally artificial heart for a complex postinfarction ventricular septal defect. (23803241)
2013
5
'Just-flow' images of the fetal heart: insights into interventricular shunting across a small ventricular septal defect and enhanced visualization of the fetal heart. (22887714)
2013
6
Echocardiographic features defining right dominant unbalanced atrioventricular septal defect: a multi-institutional Congenital Heart Surgeons' Society study. (23784944)
2013
7
The role of the total artificial heart in the treatment of post-myocardial infarction ventricular septal defect. (23219500)
2013
8
Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16. (23708191)
2013
9
Clinical and pathologic comparison of simple left-to-right shunt congenital heart disease and transposition of the great arteries with ventricular septal defect. (22543345)
2012
10
Gunshot wounds: causing myocardial infarction, delayed ventricular septal defect, and congestive heart failure. (22412248)
2012
11
Severe aortic stenosis, bicuspid aortic valve and atrial septal defect in a child with Joubert Syndrome and Related Disorders (JSRD) - a case report and review of congenital heart defects reported in the human ciliopathies. (22910529)
2012
12
Giant Dilatation of the Right Coronary Aortic Bulb with Compression of the Right Ventricular Outflow Tract Mimicking a Ventricular Septal Defect: Diagnostic workup Using Echocardiography, Heart Catheterization, and Cardiac Computed Tomography. (22952479)
2012
13
No escape from a VSD device? Complete heart block and cardiac arrest associated with a ventricular septal defect occluder device. (21851474)
2012
14
Palliative arterial switch operation in the context of multiple ventricular septal defects, potentially biventricular and univentricular hearts with malposed great arteries: a review of 15 cases. (23804860)
2012
15
Risk factors and outcomes of post-procedure heart blocks after transcatheter device closure of perimembranous ventricular septal defect. (22516400)
2012
16
Port-access heart surgery for the treatment of cor triatriatum with atrial septal defect: Report of a case. (21922368)
2011
17
Surgical interventions for atrioventricular septal defect subtypes: the pediatric heart network experience. (21872212)
2011
18
Does the technique of interventional closure of perimembranous ventricular septal defect reduce the incidence of heart block? (21281545)
2011
19
Maternal alcohol drinking pattern during pregnancy and the risk for an offspring with an isolated congenital heart defect and in particular a ventricular septal defect or an atrial septal defect. (21591246)
2011
20
Perventricular device closure of post-myocardial infarction ventricular septal defect on the beating heart. (21247590)
2011
21
A penetrating heart injury resulting in ventricular septal defect. (21292609)
2011
22
Echocardiographic diagnosis of atrioventricular septal defect without primum atrial septal defect: a relatively "common" congenital heart defect in Down's syndrome. (21362598)
2011
23
Surgery for transposition of the great arteries, ventricular septal defect and left ventricular outflow tract obstruction: European Congenital Heart Surgeons Association multicentre study. (20466558)
2010
24
Echocardiographic definition and surgical decision-making in unbalanced atrioventricular septal defect: a Congenital Heart Surgeons' Society multiinstitutional study. (20837915)
2010
25
Usefulness of early diastolic mitral annular velocity to predict plasma levels of brain natriuretic peptide and transient heart failure development after device closure of atrial septal defect. (19962485)
2009
26
Heart-lung transplantation in patients with pulmonary atresia and ventricular septal defect. (19698864)
2009
27
Early atrial septal defect surgery due to a bronchogenic cyst causing congestive heart failure by left atrium compression. (18375450)
2008
28
Identification of differentially expressed genes in human heart with ventricular septal defect using suppression subtractive hybridization. (16472770)
2006
29
Hypoplastic left heart syndrome with restrictive atrial septal defect: influence on cardiac transplantation. (15493071)
2004
30
Cardiac homeobox gene NKX2-5 mutations and congenital heart disease: associations with atrial septal defect and hypoplastic left heart syndrome. (12798584)
2003
31
Prevalence and prognosis of atrial septal aneurysm in high risk fetuses without structural heart defects. (12066564)
2002
32
Growth parameters and endocrine function in relation to echocardiographic parameters in children with ventricular septal defect without heart failure. (11419677)
2001
33
Modified Rastelli using an autograft: A new concept for correction of transposition of the great arteries with ventricular septal defect and left ventricular outflow tract obstruction (with an extension to other congenital heart defects). (11486190)
2000
34
Partial atrioventricular septal defect causing confusion with rheumatic heart disease in children in Harare--case reports. (10746401)
1999
35
Eisenmenger syndrome in adults: ventricular septal defect, truncus arteriosus, univentricular heart. (10400015)
1999
36
Congenital cataract, microphthalmia and septal heart defect in two generations: a new syndrome? (8281271)
1993
37
Acyanotic congenital heart disease. Atrial and ventricular septal defects, atrioventricular canal, patent ductus arteriosus, pulmonic stenosis. (8252562)
1993
38
Unique variant of Taussig-Bing heart: double-outlet right ventricle with double ventricular septal defects and double overriding of great arteries. (1866333)
1991
39
Right-sided heart with mirror-image atrial arrangement, complete transposition, ventricular septal defect and subpulmonary stenosis. (2914748)
1989
40
Left atrial isomerism combined with right-sided heart, common atrium, incomplete atrioventricular septal defect and partial anomalous systemic and pulmonary venous drainage. Report of a case with successful surgical correction. (3397202)
1988
41
An easy and safe technique for ventricular septal defect closure in hearts with atrioventricular discordant connection and dextrocardia. (3675063)
1987
42
Long-term management of bradyarrhythmias following open heart surgery: surgical A-V block and sick sinus syndrome after surgery for secundum atrial septal defects treated with permanent cardiac pacing. (3099026)
1986
43
Heart block and atrioventricular septal defect. (2417374)
1985
44
Balloon occlusion of atrial septal defect to assess right ventricular capability in hypoplastic right heart syndrome. (6225563)
1983
45
Criss-cross heart--a case with horizontal septum, complete transposition, pulmonary atresia and ventricular septal defect. (7163021)
1982
46
Palliative repair of transposition of the great arteries with criss-cross heart: ventricular septal defect and hypoplastic right (systemic) ventricle. (6176816)
1982
47
Open-heart palliative surgery for pulmonary atresia with ventricular septal defect and hypoplastic pulmonary arteries. (83013)
1978
48
Rheumatic heart disease associated with atrial septal defect: clinical and pathologic study of 12 cases of Lutembacher's syndrome. (13617192)
1959
49
Pure ventricular septal defect and ventricular septal defect with pulmonic stenosis; hemodynamic and clinical changes following open heart surgery. (13670116)
1959
50
CONGENITAL HEART BLOCK WITH ATRIAL AND VENTRICULAR SEPTAL DEFECT. (18609914)
1943

Genetic Variations for Heart Septal Defect

Expression for genes affiliated with Heart Septal Defect

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Heart Septal Defect

Search GEO for disease gene expression data for Heart Septal Defect.

Pathways for genes affiliated with Heart Septal Defect

Sources:
38NCBI BioSystems Database
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Pathways related to Heart Septal Defect according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.6MYH6, NKX2-5

Compounds for genes affiliated with Heart Septal Defect

GO Terms for genes affiliated with Heart Septal Defect

Sources:
16Gene Ontology
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Biological processes related to Heart Septal Defect according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1adult heart developmentGO:0075129.6MYH6, NKX2-5
2canonical Wnt receptor signaling pathwayGO:0600709.6MYH6, NKX2-5
3sarcomere organizationGO:0452149.5MYH6, NKX2-5
4BMP signaling pathwayGO:0305099.3MYH6, NKX2-5

Products for genes affiliated with Heart Septal Defect

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Sources for Heart Septal Defect

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet