MCID: HVY003
MIFTS: 23

Heavy Chain Deposition Disease

Categories: Nephrological diseases, Blood diseases, Rare diseases

Aliases & Classifications for Heavy Chain Deposition Disease

Summaries for Heavy Chain Deposition Disease

MalaCards based summary : Heavy Chain Deposition Disease, also known as hcdd, is related to light and heavy chain deposition disease and gamma heavy chain disease. An important gene associated with Heavy Chain Deposition Disease is IGHG1 (Immunoglobulin Heavy Constant Gamma 1 (G1m Marker)). The drugs Dexamethasone and Melphalan have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and kidney.

Related Diseases for Heavy Chain Deposition Disease

Diseases related to Heavy Chain Deposition Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 light and heavy chain deposition disease 12.5
2 gamma heavy chain disease 11.3
3 cutis laxa 10.1
4 acquired cutis laxa 10.1
5 light chain deposition disease 10.0
6 amyloidosis 10.0
7 lung cancer 9.8
8 myeloma, multiple 9.8
9 microvascular complications of diabetes 3 9.8
10 microvascular complications of diabetes 4 9.8
11 microvascular complications of diabetes 6 9.8
12 microvascular complications of diabetes 7 9.8
13 glomerulonephritis 9.8
14 lymphoma 9.8
15 proliferative glomerulonephritis 9.8
16 neuropathy 9.8

Graphical network of the top 20 diseases related to Heavy Chain Deposition Disease:



Diseases related to Heavy Chain Deposition Disease

Symptoms & Phenotypes for Heavy Chain Deposition Disease

Drugs & Therapeutics for Heavy Chain Deposition Disease

Drugs for Heavy Chain Deposition Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
2
Melphalan Approved 148-82-3 460612 4053
3
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
4
Bortezomib Approved, Investigational 179324-69-7 387447 93860
5 Dexamethasone acetate 1177-87-3
6 glucocorticoids
7
protease inhibitors
8 Myeloma Proteins
9 Gastrointestinal Agents
10 HIV Protease Inhibitors
11 Hormone Antagonists
12 Hormones
13 Paraproteins
14 Hormones, Hormone Substitutes, and Hormone Antagonists
15 Peripheral Nervous System Agents
16 Antiemetics
17 Immunoglobulins
18 Anti-Inflammatory Agents
19 Antineoplastic Agents, Hormonal
20 Antibodies
21 BB 1101
22 Autonomic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Bortezomib/Dexamethasone (BD), Followed By Autologous Stem Cell Transplantation and Maintenance Bortezomib/Dexamethasone For the Initial Treatment of Monoclonal Immunoglobulin Deposition Disease (MIDD) Associated With Multiple Myeloma and AL Amyloidosis Active, not recruiting NCT01383759 Bortezomib/Dexamethasone (BD), Followed By Autologous STC & Maintenance Bortezomib/Dexamethasone

Search NIH Clinical Center for Heavy Chain Deposition Disease

Genetic Tests for Heavy Chain Deposition Disease

Anatomical Context for Heavy Chain Deposition Disease

MalaCards organs/tissues related to Heavy Chain Deposition Disease:

38
Skin, Lung, Kidney, Skeletal Muscle

Publications for Heavy Chain Deposition Disease

Articles related to Heavy Chain Deposition Disease:

(show all 47)
# Title Authors Year
1
Acquired Cutis Laxa Associated with Light and Heavy Chain Deposition Disease. ( 29441298 )
2018
2
New insights into the pathogenesis and treatment of heavy chain deposition disease. ( 28087006 )
2017
3
Unravelling the immunopathological mechanisms of heavy chain deposition disease with implicationsA for clinical management. ( 27773425 )
2017
4
AJKD Atlas of Renal Pathology: Heavy Chain Deposition Disease. ( 26916378 )
2016
5
Light and heavy chain deposition disease associated with CH1 deletion. ( 25815184 )
2015
6
A Case of IgG2 Heavy Chain Deposition Disease in a Patient with Kappa Positive Plasma Cell Dyscrasia. ( 25849668 )
2015
7
A mouse model recapitulating human monoclonal heavy chain deposition disease evidences the relevance of proteasome inhibitor therapy. ( 26113545 )
2015
8
Probable light- and heavy-chain deposition disease in a patient with nodular diabetic glomerulosclerosis. ( 28509191 )
2014
9
IgD Heavy-Chain Deposition Disease: Detection by Laser Microdissection and Mass Spectrometry. ( 25194005 )
2014
10
A Unique Case of I^-heavy Chain Deposition Disease Characterized by Concomitant Deposition of I^2 and I^4 Subclasses. ( 25400185 )
2014
11
Acquired cutis laxa associated with heavy chain deposition disease involving dermal elastic fibers. ( 25133950 )
2014
12
Use of bortezomib in heavy-chain deposition disease: a report of 3 cases. ( 24613055 )
2014
13
A case of renal I^2 heavy-chain deposition disease accompanied by rapid progressive renal failure. ( 23963539 )
2013
14
Heavy chain deposition disease: an overview. ( 23652830 )
2013
15
Heavy-chain deposition disease: a morphological, immunofluorescence and ultrastructural assessment. ( 26019812 )
2012
16
High-dose melphalan followed by auto-SCT has favorable safety and efficacy in selected patients with light chain deposition disease and light and heavy chain deposition disease. ( 21499318 )
2012
17
Long-term follow-up after autologous stem cell transplantation for light- and heavy-chain deposition disease. ( 22231462 )
2012
18
Renal crescentic alpha heavy chain deposition disease: a report of 3 cases and review of the literature. ( 21944962 )
2011
19
Pulmonary light and heavy chain deposition disease: a pitfall for lung cancer evaluation with F-18 FDG PET/CT. ( 20631525 )
2010
20
Intracellular extraocular muscle light- and heavy-chain deposition disease contributing to compressive optic neuropathy in a patient with preexisting Graves' orbitopathy. ( 19707026 )
2010
21
Clinicopathological features and prognosis in immunoglobulin light and heavy chain deposition disease. ( 19203545 )
2009
22
Acquired cutis laxa associated with heavy chain deposition disease. ( 19119136 )
2008
23
Clinical remission and histopathological resolution of nodular lesions in a patient with gamma3 heavy-chain deposition disease. ( 18538103 )
2008
24
A concurrence of light and heavy chain deposition disease and diabetic nephropathy. ( 18041443 )
2007
25
Immunoglobulin light (heavy)-chain deposition disease: from molecular medicine to pathophysiology-driven therapy. ( 17699367 )
2006
26
Recurrent light and heavy chain deposition disease after renal transplantation. ( 15840680 )
2005
27
Development of systemic lambda-light chain amyloidosis in a patient with gamma-heavy chain deposition disease during long-term follow-up. ( 15673693 )
2005
28
High dose chemotherapy and stem cell support in a patient of light- and heavy-chain deposition disease with abnormal marrow cell surface antigens and no monoclonal protein. ( 16258214 )
2005
29
Light- and heavy-chain deposition disease (LHCDD): difficulty in diagnosis and treatment. ( 16258202 )
2005
30
A case of monoclonal immunoglobulin light- and heavy-chain deposition disease exhibiting atypical deposition with fibrillary structures, successfully treated with chemotherapy. ( 16175947 )
2005
31
Intracapillary proliferative glomerulonephritis due to heavy chain deposition disease. ( 15102968 )
2004
32
Nodal marginal-zone lymphoma associated with monoclonal light-chain and heavy-chain deposition disease. ( 15172359 )
2004
33
High dose chemotherapy in light chain or light and heavy chain deposition disease. ( 14717936 )
2004
34
Articular, monoclonal gamma3 heavy-chain deposition disease: characterization of a partially deleted heavy-chain gene and its protein product synthesized in vivo and in vitro. ( 14613292 )
2003
35
Generalized cutis laxa associated with heavy chain deposition disease. ( 14973644 )
2003
36
Abnormal immunoglobulin synthesis in monoclonal immunoglobulin light chain and light and heavy chain deposition disease. ( 11409038 )
2001
37
Heavy chain deposition disease: recurrence in a renal transplant and report of IgG(2) subtype. ( 10793054 )
2000
38
The amino acid sequence of a monoclonal gamma 3-heavy chain from a patient with articular gamma-heavy chain deposition disease. ( 10849371 )
2000
39
Non-amyloid fibrils in heavy chain deposition disease. ( 10504516 )
1999
40
Heavy chain deposition disease: the disease spectrum. ( 10213655 )
1999
41
IgG heavy-chain deposition disease affecting kidney, skin, and skeletal muscle. ( 9681738 )
1998
42
Structure of abnormal heavy chains in human heavy-chain-deposition disease. ( 7744049 )
1995
43
Gamma-heavy chain deposition disease showing nodular glomerulosclerosis. ( 8719552 )
1995
44
Light-heavy chain deposition disease progressing to multiple myeloma. ( 7485106 )
1995
45
IgG heavy-chain deposition disease. ( 7838842 )
1994
46
Brief report: heavy-chain deposition disease. ( 8413435 )
1993
47
Mechanisms of disease: monoclonal immunoglobulin deposition. Amyloidosis, light chain deposition disease, and light and heavy chain deposition disease. ( 1582976 )
1992

Variations for Heavy Chain Deposition Disease

Expression for Heavy Chain Deposition Disease

Search GEO for disease gene expression data for Heavy Chain Deposition Disease.

Pathways for Heavy Chain Deposition Disease

GO Terms for Heavy Chain Deposition Disease

Sources for Heavy Chain Deposition Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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