MCID: HVY003
MIFTS: 21

Heavy Chain Deposition Disease

Categories: Nephrological diseases, Blood diseases, Rare diseases

Aliases & Classifications for Heavy Chain Deposition Disease

Summaries for Heavy Chain Deposition Disease

MalaCards based summary : Heavy Chain Deposition Disease, also known as hcdd, is related to light and heavy chain deposition disease and gamma heavy chain disease. An important gene associated with Heavy Chain Deposition Disease is IGHG1 (Immunoglobulin Heavy Constant Gamma 1 (G1m Marker)). The drugs Dexamethasone and Melphalan have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and kidney.

Related Diseases for Heavy Chain Deposition Disease

Diseases related to Heavy Chain Deposition Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
id Related Disease Score Top Affiliating Genes
1 light and heavy chain deposition disease 12.3
2 gamma heavy chain disease 11.2
3 cutis laxa 10.0
4 light chain deposition disease 9.9
5 acquired cutis laxa 9.9
6 amyloidosis 9.9
7 lung cancer 9.8
8 multiple myeloma 9.8
9 glomerulonephritis 9.8
10 lymphoma 9.8
11 proliferative glomerulonephritis 9.8
12 neuropathy 9.8

Graphical network of the top 20 diseases related to Heavy Chain Deposition Disease:



Diseases related to Heavy Chain Deposition Disease

Symptoms & Phenotypes for Heavy Chain Deposition Disease

Drugs & Therapeutics for Heavy Chain Deposition Disease

Drugs for Heavy Chain Deposition Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
2
Melphalan Approved 148-82-3 4053 460612
3
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
4
Bortezomib Approved, Investigational 179324-69-7 387447 93860
5 Dexamethasone acetate 1177-87-3
6 glucocorticoids
7
protease inhibitors
8 Myeloma Proteins
9 Gastrointestinal Agents
10 HIV Protease Inhibitors
11 Hormone Antagonists
12 Hormones
13 Paraproteins
14 Hormones, Hormone Substitutes, and Hormone Antagonists
15 Peripheral Nervous System Agents
16 Immunoglobulins
17 Anti-Inflammatory Agents
18 Antiemetics
19 Antibodies
20 BB 1101
21 Autonomic Agents
22 Antineoplastic Agents, Hormonal

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Bortezomib/Dexamethasone (BD), Followed By Autologous Stem Cell Transplantation and Maintenance Bortezomib/Dexamethasone For the Initial Treatment of Monoclonal Immunoglobulin Deposition Disease (MIDD) Associated With Multiple Myeloma and AL Amyloidosis Active, not recruiting NCT01383759 Bortezomib/Dexamethasone (BD), Followed By Autologous STC & Maintenance Bortezomib/Dexamethasone

Search NIH Clinical Center for Heavy Chain Deposition Disease

Genetic Tests for Heavy Chain Deposition Disease

Anatomical Context for Heavy Chain Deposition Disease

MalaCards organs/tissues related to Heavy Chain Deposition Disease:

39
Skin, Lung, Kidney, Skeletal Muscle

Publications for Heavy Chain Deposition Disease

Articles related to Heavy Chain Deposition Disease:

(show all 46)
id Title Authors Year
1
Unravelling the immunopathological mechanisms of heavy chain deposition disease with implicationsA for clinical management. ( 27773425 )
2017
2
New insights into the pathogenesis and treatment of heavy chain deposition disease. ( 28087006 )
2017
3
AJKD Atlas of Renal Pathology: Heavy Chain Deposition Disease. ( 26916378 )
2016
4
A Case of IgG2 Heavy Chain Deposition Disease in a Patient with Kappa Positive Plasma Cell Dyscrasia. ( 25849668 )
2015
5
Light and heavy chain deposition disease associated with CH1 deletion. ( 25815184 )
2015
6
A mouse model recapitulating human monoclonal heavy chain deposition disease evidences the relevance of proteasome inhibitor therapy. ( 26113545 )
2015
7
A Unique Case of I^-heavy Chain Deposition Disease Characterized by Concomitant Deposition of I^2 and I^4 Subclasses. ( 25400185 )
2014
8
Acquired cutis laxa associated with heavy chain deposition disease involving dermal elastic fibers. ( 25133950 )
2014
9
Use of bortezomib in heavy-chain deposition disease: a report of 3 cases. ( 24613055 )
2014
10
Probable light- and heavy-chain deposition disease in a patient with nodular diabetic glomerulosclerosis. ( 28509191 )
2014
11
IgD Heavy-Chain Deposition Disease: Detection by Laser Microdissection and Mass Spectrometry. ( 25194005 )
2014
12
Heavy chain deposition disease: an overview. ( 23652830 )
2013
13
A case of renal I^2 heavy-chain deposition disease accompanied by rapid progressive renal failure. ( 23963539 )
2013
14
Heavy-chain deposition disease: a morphological, immunofluorescence and ultrastructural assessment. ( 26019812 )
2012
15
High-dose melphalan followed by auto-SCT has favorable safety and efficacy in selected patients with light chain deposition disease and light and heavy chain deposition disease. ( 21499318 )
2012
16
Long-term follow-up after autologous stem cell transplantation for light- and heavy-chain deposition disease. ( 22231462 )
2012
17
Renal crescentic alpha heavy chain deposition disease: a report of 3 cases and review of the literature. ( 21944962 )
2011
18
Intracellular extraocular muscle light- and heavy-chain deposition disease contributing to compressive optic neuropathy in a patient with preexisting Graves' orbitopathy. ( 19707026 )
2010
19
Pulmonary light and heavy chain deposition disease: a pitfall for lung cancer evaluation with F-18 FDG PET/CT. ( 20631525 )
2010
20
Clinicopathological features and prognosis in immunoglobulin light and heavy chain deposition disease. ( 19203545 )
2009
21
Clinical remission and histopathological resolution of nodular lesions in a patient with gamma3 heavy-chain deposition disease. ( 18538103 )
2008
22
Acquired cutis laxa associated with heavy chain deposition disease. ( 19119136 )
2008
23
A concurrence of light and heavy chain deposition disease and diabetic nephropathy. ( 18041443 )
2007
24
Immunoglobulin light (heavy)-chain deposition disease: from molecular medicine to pathophysiology-driven therapy. ( 17699367 )
2006
25
High dose chemotherapy and stem cell support in a patient of light- and heavy-chain deposition disease with abnormal marrow cell surface antigens and no monoclonal protein. ( 16258214 )
2005
26
Development of systemic lambda-light chain amyloidosis in a patient with gamma-heavy chain deposition disease during long-term follow-up. ( 15673693 )
2005
27
A case of monoclonal immunoglobulin light- and heavy-chain deposition disease exhibiting atypical deposition with fibrillary structures, successfully treated with chemotherapy. ( 16175947 )
2005
28
Recurrent light and heavy chain deposition disease after renal transplantation. ( 15840680 )
2005
29
Light- and heavy-chain deposition disease (LHCDD): difficulty in diagnosis and treatment. ( 16258202 )
2005
30
Nodal marginal-zone lymphoma associated with monoclonal light-chain and heavy-chain deposition disease. ( 15172359 )
2004
31
High dose chemotherapy in light chain or light and heavy chain deposition disease. ( 14717936 )
2004
32
Intracapillary proliferative glomerulonephritis due to heavy chain deposition disease. ( 15102968 )
2004
33
Articular, monoclonal gamma3 heavy-chain deposition disease: characterization of a partially deleted heavy-chain gene and its protein product synthesized in vivo and in vitro. ( 14613292 )
2003
34
Generalized cutis laxa associated with heavy chain deposition disease. ( 14973644 )
2003
35
Abnormal immunoglobulin synthesis in monoclonal immunoglobulin light chain and light and heavy chain deposition disease. ( 11409038 )
2001
36
The amino acid sequence of a monoclonal gamma 3-heavy chain from a patient with articular gamma-heavy chain deposition disease. ( 10849371 )
2000
37
Heavy chain deposition disease: recurrence in a renal transplant and report of IgG(2) subtype. ( 10793054 )
2000
38
Heavy chain deposition disease: the disease spectrum. ( 10213655 )
1999
39
Non-amyloid fibrils in heavy chain deposition disease. ( 10504516 )
1999
40
IgG heavy-chain deposition disease affecting kidney, skin, and skeletal muscle. ( 9681738 )
1998
41
Structure of abnormal heavy chains in human heavy-chain-deposition disease. ( 7744049 )
1995
42
Gamma-heavy chain deposition disease showing nodular glomerulosclerosis. ( 8719552 )
1995
43
Light-heavy chain deposition disease progressing to multiple myeloma. ( 7485106 )
1995
44
IgG heavy-chain deposition disease. ( 7838842 )
1994
45
Brief report: heavy-chain deposition disease. ( 8413435 )
1993
46
Mechanisms of disease: monoclonal immunoglobulin deposition. Amyloidosis, light chain deposition disease, and light and heavy chain deposition disease. ( 1582976 )
1992

Variations for Heavy Chain Deposition Disease

Expression for Heavy Chain Deposition Disease

Search GEO for disease gene expression data for Heavy Chain Deposition Disease.

Pathways for Heavy Chain Deposition Disease

GO Terms for Heavy Chain Deposition Disease

Sources for Heavy Chain Deposition Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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