Heavy Chain Disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Heavy Chain Disease

Sources:
⁹Disease Ontology, ⁶⁴Wikipedia, ³²MalaCards
See all sources

Disease Ontology:⁹ A hypersensitivity reaction type iv disease that results from a proliferation of cells producing immunoglobulin heavy chains.

MalaCards based summary: Heavy Chain Disease, also known as HCD, is related to gamma heavy chain disease and alpha heavy-chain disease. An important gene associated with Heavy Chain Disease is IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker)). The compounds agar and thyroxine have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and thyroid.

Wikipedia:⁶⁴ Heavy chain disease is a form of paraproteinemia with a proliferation of cells producing immunoglobulin... more...

Aliases & Classifications for Heavy Chain Disease

Sources:
⁹Disease Ontology, ¹¹DISEASES, ⁴⁸Orphanet, ⁶¹UMLS, ³⁴MeSH, ³⁵MESH via Orphanet, ²⁷ICD10 via Orphanet, ⁶²UMLS via Orphanet
See all sources

Heavy Chain Disease, Aliases & Descriptions:

Name: Heavy Chain Disease ⁹ ¹¹ ⁴⁸ ⁶¹

Hcd ⁴⁸

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases, Rare diseases
Anatomical: Blood diseases, Immune diseases, Gastrointestinal diseases

ICD10: ²⁷

Neoplasms

Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue

Malignant immunoproliferative diseases

Other heavy chain disease

Immunoproliferative small intestinal disease

Orphanet: ⁴⁸

Rare haematological diseases

Rare tumors

Characteristics (Orphanet epidemiological data):

⁴⁸

heavy chain disease:
Age of onset: Adulthood

External Ids:

Disease Ontology⁹ DOID:0060125

MeSH³⁴ D006362

MESH via Orphanet³⁵ D006362

ICD10 via Orphanet²⁷ C88.2, C88.3

UMLS via Orphanet⁶² C0018852

Related Diseases for Heavy Chain Disease

Sources:
¹⁸GeneCards, ¹⁹GeneDecks
See all sources

Diseases in the Gamma Heavy Chain Disease family:

heavy chain disease	Alpha Heavy-Chain Disease

Diseases related to Heavy Chain Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 34)

id	Related Disease	Score	Top Affiliating Genes
1	gamma heavy chain disease	31.9	IGHV1-2
2	alpha heavy-chain disease	10.9
3	arthritis	10.5
4	rheumatoid arthritis	10.4
5	myeloma	10.4
6	mu chain disease	10.3
7	alpha chain disease	10.3
8	agammaglobulinemia	10.3
9	intestinal disease	10.3
10	cryoglobulinemia	10.2
11	gastrointestinal lymphoma	10.2
12	lymphoplasmacytic lymphoma	10.2
13	thyroiditis	10.2
14	splenomegaly	10.2
15	hodgkin's lymphoma	10.1
16	leukemia	10.1
17	non-hodgkin lymphoma	10.1
18	small intestine lymphoma	10.1
19	splenic marginal zone lymphoma	10.1
20	duodenal ulcer	10.1
21	hypercalcemia	10.1
22	macroglobulinemia	10.1
23	pancytopenia	10.1
24	t-cell large granular lymphocyte leukemia	10.1
25	delta chain disease	10.1
26	duodenitis	10.1
27	amyloidosis	10.1
28	goiter	10.1
29	plasma cell neoplasm	10.1
30	plasmacytoma	10.1
31	immunotactoid glomerulopathy	10.1
32	large granular lymphocyte leukemia	10.1
33	hypertension	9.9	CD79A, PNMT
34	ulcerative colitis	9.9	SLC3A2, CD79A

Graphical network of the top 20 diseases related to Heavy Chain Disease:

Symptoms for Heavy Chain Disease

Drugs & Therapeutics for Heavy Chain Disease

Sources:
⁴¹NIH Clinical Center, ⁶ClinicalTrials
See all sources

Drug clinical trials:

Search ClinicalTrials for Heavy Chain Disease

Search NIH Clinical Center for Heavy Chain Disease

Genetic Tests for Heavy Chain Disease

Anatomical Context for Heavy Chain Disease

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Heavy Chain Disease:

³²

Small intestine, Testes, Thyroid, T cells, Lymph node, Skin, B cells

Animal Models for Heavy Chain Disease or affiliated genes

Publications for Heavy Chain Disease

Sources:
⁵¹PubMed
See all sources

Articles related to Heavy Chain Disease:

(show top 50) (show all 181)

id	Title	Authors	Year
1	Alpha heavy chain disease: a rare lymphoma hard to diagnose. (25125965)	Diamantidis M.... Kaiafa G.	2014
2	Analysis of patients with I^-heavy chain disease by the heavy/light chain and free light chain assays. (24327529)	Kaleta E.... Katzmann J.	2013
3	Gamma heavy-chain disease: defining the spectrum of associated lymphoproliferative disorders through analysis of 13 cases. (22301495)	Bieliauskas S.... Cook J.R.	2012
4	Unusual gamma heavy chain disease protein in a patient with splenic marginal-zone lymphoma. (16536920)	Morita K.... Okamoto Y.	2006
5	Composite nodular lymphocyte-predominance Hodgkin disease and gamma-heavy-chain disease: a case report and review of the literature. (11371236)	Hudnall S.D.... Petersen J.R.	2001
6	Is there a pathogenic link between gamma heavy chain disease and chronic arthritis? (10647957)	Husby G.	2000
7	Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease. (9482908)	Goossens T.... KA1ppers R.	1998
8	Chronic arthritis and gamma heavy chain disease: coincidence or pathogenic link? (9751465)	Husby G.... Stenstad T.	1998
9	A case of mu-heavy chain disease: combined features of mu-chain disease and macroglobulinemia. (9401282)	Iwasaki T.... Kakishita E.	1997
10	Pre-B-cell development in the absence of lambda 5 in transgenic mice expressing a heavy-chain disease protein. (8548286)	Corcos D.... Jami J.	1995
11	Malabsorption associated with a high-grade-malignant non-Hodgkin's lymphoma, alpha-heavy-chain disease and immunoproliferative small intestinal disease. (7793120)	Hubmann R.... Zazgornik I.	1995
12	Free fragments of gamma chain in the urine. A possible source of confusion with gamma heavy-chain disease. (8160637)	Charles E.Z.... Valdes A.J.	1994
13	Atrophie blanche in a patient with gamma-heavy-chain disease. (1899331)	Cooper D.L.... Lin J.T.	1991
14	Cutaneous manifestations associated with gamma heavy chain disease. Report of an unusual case and review of literature. (2121807)	Lassoued K.... Belaich S.	1990
15	A new extra sequence at the amino terminal of a mu heavy chain disease protein (DAG). (2119480)	Mihaesco C.... Mihaesco E.	1990
16	Immunochemical and structural characterization of an IgG1 heavy chain disease. (2503864)	Sala P.... Carbonara A.O.	1989
17	Gamma heavy chain disease and rheumatoid arthritis. (2658067)	Dickson J.R.... Chodirker W.B.	1989
18	Gamma heavy chain disease in man. Genomic sequence reveals two noncontiguous deletions in a single gene. (3139711)	Alexander A.... Buxbaum J.	1988
19	Elevated serum IgA associated with immunoproliferative enteropathy of Basenji dogs: lack of evidence for alpha heavy-chain disease or enhanced intestinal IgA secretion. (3149068)	De Buysscher E.V.... MacLachlan N.J.	1988
20	Alpha heavy chain disease: report of two cases. (3937780)	Geraci L.... Ascari E.	1985
21	Gamma heavy chain disease DUB: clinical, immunochemical and pathological studies. (3932151)	Roda L.... Creyssel R.	1985
22	Plasma cell infiltration of the small bowel: lack of evidence for a non-secretory form of alpha-heavy chain disease. (3928450)	Gilinsky N.H.... Marks I.N.	1985
23	Crystals of the human heavy chain disease protein Riv and human Fc fragment are isomorphous: further evidence for conformational flexibility in the hinge region of immunoglobulins. (6405046)	Mariuzza R.A.... Mihaesco E.	1983
24	The diverse picture of gamma heavy-chain disease. Report of seven cases and review of literature. (6789012)	Kyle R.A.... Banks P.M.	1981
25	The pathology of gamma heavy chain disease: report of a case with morphologic progression from lymphocytic to plasmacytic proliferation. (6790158)	Marsh W.L.... Spiegelberg H.L.	1981
26	Abnormal chromosomal marker (D14 q+) in a patient with alpha heavy chain disease. (6767755)	Gafter U.... Djaldetti M.	1980
27	Gamma heavy chain disease with an unusually benign course. (6769634)	Van Bergeijk L.... Langenhuijsen M.M.	1980
28	IgD myeloma or delta heavy-chain disease? (6766363)	Vladutiu A.O.	1980
29	delta-Heavy chain disease. A study of a case. (6777103)	Vilpo J.A.... RAPnnemaa T.	1980
30	G1 heavy chain disease: clinicopathological, ultrastructural and immunochemical study of a new case. (6766944)	Stramignoni A.... Leonardo E.	1980
31	A case of gamma 3 heavy chain disease with vacuolated plasma cells: a clinical, immunological, and ultrastructural study. (109474)	Feremans W.... Bieva C.	1979
32	Murine heavy chain disease. (95958)	Morrison S.L.	1978
33	An unusual case of a plasma cell neoplasm with an IgG3lambda myeloma and a gamma3 heavy chain disease protein. (412532)	Adlersberg J.B.... Franklin E.C.	1978
34	Gamma heavy chain disease in man: synthesis of a deleted gamma3 immunoglobulin by lymphoid cells in short and long term tissue culture. (80297)	Buxbaum J.N.... Olivier O.	1978
35	Pathological studies on a long-term survived case of gamma heavy chain disease--a brief review of 30 reported cases and a proposal for histological typing. (104544)	Ogawa K.... Arima T.	1978
36	Gamma heavy chain disease; report of an autopsy case with a review of the literatures. (822689)	Inoue T.... Tanaka Y.	1976
37	Gamma heavy chain disease in a young girl. (828123)	Dammacco F.... Bonomo L.	1976
38	N- and C-terminal amino acid sequences of a gamma-heavy chain disease protein YOK. (819357)	Nabeshima Y.... Ikenaka T.	1976
39	A case of gamma heavy chain disease associated with autoimmune haemolytic anaemia: clinical, haematological, immunological and pathological details. (821137)	Shirakura T.... Imamura Y.	1976
40	The defect in mu heavy chain disease protein GLI. (815437)	Franklin E.C.... Prelli F.	1976
41	Gamma heavy chain disease: rapid, sustained response to cyclophosphamide and prednisone. (1131420)	Lyons R.M.... Majerus P.W.	1975
42	In vitro production of an amyloid-like substance from gamma 3 heavy chain disease protein. (4609897)	Pruzanski W.... Freedman M.H.	1974
43	A new case of mu heavy chain disease: clinical and immunochemical studies. (4206914)	Dammacco F.... Franklin E.C.	1974
44	Determination of the light chain type of paraproteins, identification of heavy chain disease. (4213025)	Backhausz R.... Lajos J.	1972
45	Alpha heavy chain disease. A variant of Mediterranean lymphoma. (5093214)	Zlotnick A.... Levy M.	1971
46	Immunoglobulin M heavy chain disease: intracellular origin of the mu chain fragment. (5464612)	Buxbaum J.... Scharff M.D.	1970
47	A new variant of heavy-chain disease (mu-chain disease). (5438427)	Ballard H.S.... Illes C.H.	1970
48	Implications of heavy chain disease protein sequences for multiple gene theories of immunoglobulin synthesis. (4194868)	Terry W.D.... Ohms J.	1970
49	Heavy-chain disease. (4171785)		1968
50	HEAVY CHAIN DISEASE- A NEW DISORDER OF SERUM GAMMA-GLOBULINS : REPORT OF THE FIRST CASE. (14209281)	Franklin E.C.... Meltzer M.	1964

Genes related to Heavy Chain Disease

Sources:
¹⁸GeneCards, ¹antibodies-online, ⁴⁵Novus Biologicals
See all sources

Genes related to Heavy Chain Disease:

- Elite gene

id	Symbol	Description	Score	Implication
1	IGHG3	immunoglobulin heavy constant gamma 3 (G3m marker)	22.06	GeneCards inferred via : Publications, Gene name (show sections)
2	PNMT	phenylethanolamine N-methyltransferase	18.43	GeneCards inferred via : Disorders (show sections)
3	CD79A	CD79a molecule, immunoglobulin-associated alpha	15.10	GeneCards inferred via : Disorders (show sections)
4	IGHV1-2	immunoglobulin heavy variable 1-2	11.77	GeneCards inferred via : Disorders (show sections)
5	DDX1	DEAD (Asp-Glu-Ala-Asp) box helicase 1	8.43	GeneCards inferred via : Publications (show sections)
6	SLC3A2	solute carrier family 3 (amino acid transporter heavy chain), member 2	5.10	GeneCards inferred via : Disorders (show sections)