Heavy Chain Disease: Malacards - Research Articles, Symptoms, Drugs, Genes, Clinical Trials

Summaries for Heavy Chain Disease

Sources:
⁸Disease Ontology, ⁶³Wikipedia, ³²MalaCards
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Disease Ontology:⁸ A hypersensitivity reaction type iv disease that results from a proliferation of cells producing immunoglobulin heavy chains.

MalaCards: Heavy Chain Disease, also known as HCD, is related to gamma heavy chain disease and alpha chain disease. An important gene associated with Heavy Chain Disease is IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker)). The compound thyroxine have been mentioned in the context of this disorder. Affiliated tissues include small intestine, skeletal muscle and heart.

Wikipedia:⁶³ Heavy chain disease is a form of paraproteinemia with a proliferation of cells producing immunoglobulin... more...

Aliases & Classifications for Heavy Chain Disease

Sources:
⁸Disease Ontology, ¹⁰DISEASES, ⁴⁸Orphanet, ⁶⁰UMLS, ³⁴MeSH, ³⁵MESH via Orphanet, ²⁶ICD10 via Orphanet, ⁵⁷SNOMED-CT via Orphanet, ⁶¹UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases

ICD10: ²⁶

Neoplasms

Malignant neoplasms, stated or presumed to be primary, of lymphoid, haematopoietic and related tissue

Malignant immunoproliferative diseases

Other heavy chain disease

Immunoproliferative small intestinal disease

Characteristics (Orphanet epidemiological data):

⁴⁸

heavy chain disease:
Age of onset: Adulthood

Aliases & Descriptions:

heavy chain disease ⁸ ¹⁰ ⁴⁸ ⁶⁰

hcd ⁴⁸

External Ids:

Disease Ontology⁸ DOID:0060125

MeSH³⁴ D006362

MESH via Orphanet³⁵ D006362

ICD10 via Orphanet²⁶ C88.2, C88.3

SNOMED-CT via Orphanet⁵⁷ 6381009, 68979007

UMLS via Orphanet⁶¹ C0018852

Related Diseases for Heavy Chain Disease

Sources:
¹⁷GeneCards, ¹⁸GeneDecks
See all sources

Diseases in the Gamma Heavy Chain Disease family:

heavy chain disease	Alpha Heavy-Chain Disease

Diseases related to Heavy Chain Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 37)

id	Related Disease	Score	Top Affiliating Genes
1	gamma heavy chain disease	11.0
2	alpha chain disease	10.9
3	mu chain disease	10.7
4	intestinal disease	10.5
5	arthritis	10.5
6	delta chain disease	10.4
7	small intestine lymphoma	10.4
8	myeloma	10.4
9	rheumatoid arthritis	10.4
10	capillary disease	10.3
11	chromosomal disease	10.3
12	cryoglobulinemia	10.2
13	gastrointestinal lymphoma	10.2
14	agammaglobulinemia	10.2
15	plasma cell neoplasm	10.2
16	thyroiditis	10.2
17	alpha heavy-chain disease	10.2
18	non-hodgkin lymphoma	10.1
19	duodenal ulcer	10.1
20	thyroid lymphoma	10.1
21	macroglobulinemia	10.1
22	pancytopenia	10.1
23	duodenitis	10.1
24	hypercalcemia	10.1
25	lymphoplasmacytic lymphoma	10.1
26	t-cell large granular lymphocyte leukemia	10.1
27	splenic marginal zone lymphoma	10.1
28	amyloidosis	10.1
29	duodenal disease	10.1
30	goiter	10.1
31	hodgkin's lymphoma	10.1
32	leukemia	10.1
33	plasmacytoma	10.1
34	skin disease	10.1
35	splenic disease	10.1
36	t-cell leukemia	10.1
37	bronchitis	10.0	CD79A

Graphical network of the top 20 diseases related to Heavy Chain Disease:

Clinical Features for Heavy Chain Disease

Drugs & Therapeutics for Heavy Chain Disease

Sources:
⁵CenterWatch, ⁴¹NIH Clinical Center, ⁶ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Heavy Chain Disease

Drug clinical trials:

Search ClinicalTrials for Heavy Chain Disease

Search NIH Clinical Center for Heavy Chain Disease

Search CenterWatch for Heavy Chain Disease

Genetic Tests for Heavy Chain Disease

Anatomical Context for Heavy Chain Disease

Sources:
³²MalaCards
See all sources

MalaCards organs/tissues related to Heavy Chain Disease:

³²

Small intestine, Skeletal muscle, Heart, Testes, Skin, Thyroid, T cells, B cells, Kidney, Lymph node, Lung, Liver

Animal Models for Heavy Chain Disease or affiliated genes

Publications for Heavy Chain Disease

Sources:
⁵⁰PubMed
See all sources

Articles related to Heavy Chain Disease:

(show top 50) (show all 257)

id	Title	Authors	Year
1	Heavy chain deposition disease: an overview. (23652830)	Oe Y.... Ito S.	2013
2	High-dose melphalan followed by auto-SCT has favorable safety and efficacy in selected patients with light chain deposition disease and light and heavy chain deposition disease. (21499318)	Telio D.... Song K.W.	2012
3	Gamma heavy chain disease in a patient with underlying lymphoplasmacytic lymphoma of the thyroid. Report of a case and comparison with other reported cases with thyroid involvement. (22561184)	Tan J.N.... Erdogan E.	2012
4	Mice with mutation in dynein heavy chain 1 do not share the same tau expression pattern with mice with SOD1-related motor neuron disease. (21380844)	KuA_ma-Kozakiewicz M.... BaraA8czyk-KuA_ma A.	2011
5	Human disease caused by loss of fast IIa myosin heavy chain due to recessive MYH2 mutations. (20418530)	Tajsharghi H.... Udd B.	2010
6	Heavy chain myosin 9-related disease (MYH9 -RD): neutrophil inclusions of myosin-9 as a pathognomonic sign of the disorder. (20174760)	Savoia A.... Pecci A.	2010
7	Deficiency of ferritin heavy-chain nuclear import in triple a syndrome implies nuclear oxidative damage as the primary disease mechanism. (19855093)	Storr H.L.... Clark A.J.	2009
8	Nonmuscle myosin heavy chain 9 gene mutations related disease: a family report]. (18458691)	Hua Y.... Lu X.t.	2008
9	Multiple extranodal tumors in mu-heavy chain disease. (17050207)	Maeda A.... Takahashi T.	2006
10	High dose chemotherapy in light chain or light and heavy chain deposition disease. (14717936)	Royer B.... Fermand J.P.	2004
11	Mu-heavy chain disease associated with systemic amyloidosis. (15203869)	Kinoshita K.... Kanamaru A.	2004
12	Minimal residual disease detection in hairy cell leukemia. Comparison of flow cytometric immunophenotyping with clonal analysis using consensus primer polymerase chain reaction for the heavy chain gene. (12579991)	Sausville J.E.... Stetler-Stevenson M.	2003
13	Generalized cutis laxa associated with heavy chain deposition disease. (14973644)	Tan S.... Ghazarian D.	2003
14	Gamma-heavy chain disease: review of 23 cases. (12861101)	Wahner-Roedler D.L.... Kyle R.A.	2003
15	Immunoglobulin gene rearrangement analysis in composite hodgkin disease and large B-cell lymphoma: evidence for receptor revision of immunoglobulin heavy chain variable region genes in Hodgkin-Reed-Sternberg cells? (11854595)	Bellan C.... Tosi P.	2002
16	Heavy chain deposition disease: recurrence in a renal transplant and report of IgG(2) subtype. (10793054)	Herzenberg A.M.... Magil A.B.	2000
17	The amino acid sequence of a monoclonal gamma 3-heavy chain from a patient with articular gamma-heavy chain deposition disease. (10849371)	Danevad M.... Husby G.	2000
18	Non-amyloid fibrils in heavy chain deposition disease. (10504516)	Polski J.M.... Salinas-Madrigal L.	1999
19	A 25-kb deletion in the 5' region of the cytochrome b558 heavy chain gene (CYBB) in a patient with X-linked chronic granulomatous disease. (9099835)	Faizunnessa N.N.... Nakamura M.	1997
20	Pre-B-cell development in the absence of lambda 5 in transgenic mice expressing a heavy-chain disease protein. (8548286)	Corcos D.... Jami J.	1995
21	Primary SjAPgren's syndrome and gamma heavy chain disease. (7991295)	Castelino D.... Murphy B.	1994
22	Alpha heavy chain disease alpha mRNA contain nucleotide sequences of unknown origins. (1425927)	Fakhfakh F.... Tsapis A.	1992
23	IgG heavy-chain subclass restriction of thyrotropin-binding inhibitory immunoglobulins in Graves' disease. (1977589)	Weetman A.P.... Reimer C.B.	1990
24	A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome-positive X-linked chronic granulomatous disease. (2556453)	Dinauer M.C.... Orkin S.H.	1989
25	Rapid evolution in the immunochemical findings of a gamma heavy chain disease. (3124986)	Pontet F.... Rousselet F.	1988
26	Cutaneous lesions in gamma heavy-chain disease. (3138950)	Kanoh T.... Niwa Y.	1988
27	A pre-translational defect in a case of human mu heavy chain disease. (3099178)	Bakhshi A.... Korsmeyer S.J.	1986
28	Hypercalcemia and reversible renal failure in heavy-chain disease. (3085235)	Eisner S.B.... Mitnick P.D.	1986
29	Alpha heavy chain disease: report of two cases. (3937780)	Geraci L.... Ascari E.	1985
30	Gamma heavy-chain disease involving upper airway. (3932940)	Blum D.J.... McDonald T.J.	1985
31	Alpha heavy-chain disease presenting as goiter. (6431799)	Tracy R.P.... Leitch J.M.	1984
32	Abnormal chromosomal marker (D14 q+) in a patient with alpha heavy chain disease. (6767755)	Gafter U.... Djaldetti M.	1980
33	Primary structure of human gamma 3 immunoglobulin deletion mutant: gamma 3 heavy-chain disease protein Wis. (6774747)	Frangione B.... Franklin E.C.	1980
34	A new case of gamma heavy chain disease: clinical, immunochemical and structural characterization. (91266)	Carbonara A.O.... Franklin E.C.	1979
35	Human heavy chain disease protein WIS: implications for the organization of immunoglobulin genes. (106391)	Franklin E.C.... Frangione B.	1979
36	The immunoselection technic in laboratory diagnosis of alpha heavy-chain disease. (110138)	Al-Saleem T.I.... King J.	1979
37	Murine heavy chain disease. (95958)	Morrison S.L.	1978
38	Gamma heavy chain disease in man: synthesis of a deleted gamma3 immunoglobulin by lymphoid cells in short and long term tissue culture. (80297)	Buxbaum J.N.... Olivier O.	1978
39	Gamma heavy chain disease in man: translation and partial purification of mRNA coding for the deleted protein. (105356)	Alexander A.... Buxbaum J.	1978
40	The defect in mu heavy chain disease protein GLI. (815437)	Franklin E.C.... Prelli F.	1976
41	Mu heavy-chain disease--a defect in immunoglobulin assembly. Structural studies of the kappa chain. (824712)	Frangione B.... Prelli F.	1976
42	IgA heavy chain disease. A case detected in the western hemisphere. (1115076)	Pittman F.E.... Duque E.E.	1975
43	Alpha heavy chain disease. (1148399)	Seligmann M.	1975
44	A new case of mu heavy chain disease: clinical and immunochemical studies. (4206914)	Dammacco F.... Franklin E.C.	1974
45	The catabolism of human G immunoglobulins of different heavy chain subclasses. 3. The catabolism of heavy chain disease proteins and of Fc fragments of myeloma proteins. (4624553)	Spiegelberg H.L.... Fishkin B.G.	1972
46	Gamma heavy chain disease. Reports of three patients. (4562896)	Westin J.... Weinfeld A.	1972
47	The molecular defect in a protein (CRA) found in gamma-1 heavy chain disease, and its genetic implications. (4100047)	Franklin E.C.... Frangione B.	1971
48	A new variant of heavy-chain disease (mu-chain disease). (5438427)	Ballard H.S.... Illes C.H.	1970
49	Metabolic studies of a heavy chain disease protein. (5803791)	Ein D.... Waldmann T.A.	1969
50	HEAVY-CHAIN DISEASE. (14255250)	DEBENHAM G.P.	1965

Genes related to Heavy Chain Disease

Sources:
¹⁷GeneCards, ⁴⁵Novus Biologicals, ³¹LifeSpan BioSciences, Inc.
See all sources

Genes related to Heavy Chain Disease:

id	Symbol	Description	Score	Implication
1	IGHG3	immunoglobulin heavy constant gamma 3 (G3m marker)	22.46	GeneCards inferred : Publications, Gene name, Disorders (show sections)
2	PNMT	phenylethanolamine N-methyltransferase	18.12	GeneCards inferred : Disorders (show sections)
3	CD79A	CD79a molecule, immunoglobulin-associated alpha	14.12	GeneCards inferred : Disorders (show sections)
4	DDX1	DEAD (Asp-Glu-Ala-Asp) box helicase 1	10.12	GeneCards inferred : Publications, Disorders (show sections)
5	SLC3A2	solute carrier family 3 (amino acid transporter heavy chain), member 2	6.12	GeneCards inferred : Disorders (show sections)

Products for genes related to Heavy Chain Disease disease:

id	Company	Proteins	Lysates	Antibodies
1	Novus Biologicals	5	5	4
2	LSBio	-	-	5

Genetic Variations for Heavy Chain Disease

Expression for genes affiliated with Heavy Chain Disease

Sources:
¹BioGPS, ¹⁵Gene Expression Omnibus DataSets
See all sources

Expression patterns in normal tissues for genes affiliated with Heavy Chain Disease

Search GEO for disease gene expression data for Heavy Chain Disease.

Pathways for genes affiliated with Heavy Chain Disease

Compounds for genes affiliated with Heavy Chain Disease

Sources:
⁴⁴Novoseek, ²⁴HMDB
See all sources

Compounds related to Heavy Chain Disease according to GeneCards/GeneDecks:

id	Compound	Score	Top Affiliating Genes
1	thyroxine⁴⁴ ²⁴	10.3	SLC3A2, CD79A

GO Terms for genes affiliated with Heavy Chain Disease

Products for genes affiliated with Heavy Chain Disease

Antibodies
Proteins
Lysates

Antibodies

Sources for Heavy Chain Disease

¹BioGPS

²BitterDB

³CDC

⁴Cell Signaling Technology

⁵CenterWatch

⁶ClinicalTrials

⁷dbSNP

⁸Disease Ontology

⁹diseasecard

¹⁰DISEASES

¹¹DrugBank

¹²EMD Millipore

¹³ExPASy

¹⁴FMA

¹⁵Gene Expression Omnibus DataSets

¹⁶Gene Ontology

¹⁷GeneCards

¹⁸GeneDecks

¹⁹GeneReviews

²⁰GeneTests

²¹Genetics Home Reference

²²GTR

²³HGMD

²⁴HMDB

²⁵ICD10

²⁶ICD10 via Orphanet

²⁷ICD9CM

²⁸IUPHAR

²⁹KEGG

³⁰LifeMap Discovery™

³¹LifeSpan BioSciences, Inc.

³²MalaCards

³³MedlinePlus

³⁴MeSH

³⁵MESH via Orphanet

³⁶MGI

³⁷NCBI BioSystems Database

³⁸NCBI Bookshelf

³⁹NCIt

⁴⁰NDF-RT

⁴¹NIH Clinical Center

⁴²NIH Rare Diseases

⁴³NINDS

⁴⁴Novoseek

⁴⁵Novus Biologicals

⁴⁶OMIM

⁴⁷OMIM via Orphanet

⁴⁸Orphanet

⁴⁹PharmGKB

⁵⁰PubMed

⁵¹QIAGEN

⁵²R&D Systems

⁵³Reactome

⁵⁴SABiosciences

⁵⁵SinoBiological

⁵⁶SNOMED-CT

⁵⁷SNOMED-CT via Orphanet

⁵⁸Thomson Reuters

⁵⁹Tocris Bioscience

⁶⁰UMLS

⁶¹UMLS via Orphanet

⁶²UniProtKB/Swiss-Prot

⁶³Wikipedia

HCD MCID: HVY001 MIFTS: 35	Heavy Chain Disease (HCD) malady Blood diseases, Cancer diseases categories
5 genes, 12 tissues, 37 related diseases, clinical trials.

Heavy Chain Disease (HCD) malady