HCD
MCID: HVY001
MIFTS: 35

Heavy Chain Disease (HCD) malady

Blood diseases, Cancer diseases categories

Summaries for Heavy Chain Disease

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Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A hypersensitivity reaction type iv disease that results from a proliferation of cells producing immunoglobulin heavy chains.

MalaCards: Heavy Chain Disease, also known as HCD, is related to gamma heavy chain disease and alpha chain disease. An important gene associated with Heavy Chain Disease is IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker)). The compound thyroxine have been mentioned in the context of this disorder. Affiliated tissues include small intestine, skeletal muscle and heart.

Wikipedia:63 Heavy chain disease is a form of paraproteinemia with a proliferation of cells producing immunoglobulin... more...

Aliases & Classifications for Heavy Chain Disease

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Sources:
8Disease Ontology, 10DISEASES, 48Orphanet, 60UMLS, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
heavy chain disease:
Age of onset: Adulthood


Aliases & Descriptions:

heavy chain disease 8 10 48 60
hcd 48


External Ids:

Disease Ontology8 DOID:0060125
MeSH34 D006362
MESH via Orphanet35 D006362
ICD10 via Orphanet26 C88.2, C88.3
SNOMED-CT via Orphanet57 6381009, 68979007
UMLS via Orphanet61 C0018852

Related Diseases for Heavy Chain Disease

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Heavy Chain Disease:



Diseases related to heavy chain disease

Clinical Features for Heavy Chain Disease

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Drugs & Therapeutics for Heavy Chain Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search CenterWatch for Heavy Chain Disease

Genetic Tests for Heavy Chain Disease

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Anatomical Context for Heavy Chain Disease

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Sources:
32MalaCards
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MalaCards organs/tissues related to Heavy Chain Disease:

32
Small intestine, Skeletal muscle, Heart, Testes, B cells, T cells, Skin, Thyroid, Lung, Liver, Kidney, Lymph node

Animal Models for Heavy Chain Disease or affiliated genes

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Publications for Heavy Chain Disease

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Sources:
50PubMed
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Articles related to Heavy Chain Disease:

(show top 50)    (show all 257)
idTitleAuthorsYear
1
A case of renal I^2 heavy-chain deposition disease accompanied by rapid progressive renal failure. (23963539)
2013
2
Analysis of patients with I^-heavy chain disease by the heavy/light chain and free light chain assays. (24327529)
2013
3
Long-term follow-up after autologous stem cell transplantation for light- and heavy-chain deposition disease. (22231462)
2012
4
Pulmonary light and heavy chain deposition disease: a pitfall for lung cancer evaluation with F-18 FDG PET/CT. (20631525)
2010
5
Intracellular extraocular muscle light- and heavy-chain deposition disease contributing to compressive optic neuropathy in a patient with preexisting Graves' orbitopathy. (19707026)
2010
6
Staging multiple myeloma patients with active disease using serum levels of beta2m-free HLA class I heavy chain together with IgM or platelet count. (18996035)
2009
7
Sarcomere protein gene mutations and inherited heart disease: a beta-cardiac myosin heavy chain mutation causing endocardial fibroelastosis and heart failure. (17019812)
2006
8
Immunoglobulin light (heavy)-chain deposition disease: from molecular medicine to pathophysiology-driven therapy. (17699367)
2006
9
Non-muscle myosin heavy chain IIA and IIB interact and co-localize in living cells: relevance for MYH9-related disease. (16596254)
2006
10
Heavy chain disease can be detected by capillary zone electrophoresis. (15613723)
2005
11
High dose chemotherapy and stem cell support in a patient of light- and heavy-chain deposition disease with abnormal marrow cell surface antigens and no monoclonal protein. (16258214)
2005
12
A case of monoclonal immunoglobulin light- and heavy-chain deposition disease exhibiting atypical deposition with fibrillary structures, successfully treated with chemotherapy. (16175947)
2005
13
Myosin heavy chain composition and the economy of contraction in healthy and diseased human myocardium. (16088376)
2005
14
Successful treatment of mu-heavy chain disease with fludarabine monophosphate: a case report. (15005347)
2004
15
Intracapillary proliferative glomerulonephritis due to heavy chain deposition disease. (15102968)
2004
16
Metachronous development of nonamyloidogenic [lambda] light chain deposition disease and IgG heavy chain amyloidosis in the same patient. (14576484)
2003
17
Heavy chain disease. (12057070)
2002
18
Composite nodular lymphocyte-predominance Hodgkin disease and gamma-heavy-chain disease: a case report and review of the literature. (11371236)
2001
19
Test and teach. Laboratory characterisation of paraproteins. Heavy chain disease. (11523944)
2001
20
Is there a pathogenic link between gamma heavy chain disease and chronic arthritis? (10647957)
2000
21
VH and VL gene usage by anti-beta-amyloid autoantibodies in Alzheimer's disease: detection of highly mutated V regions in both heavy and light chains. (7704974)
1995
22
Coexpression of alpha and beta myosin heavy-chain isoforms in atria of neonates and infants with congenital heart disease. (8240229)
1993
23
A newly recognized point mutation in the cytochrome b558 heavy chain gene replacing alanine57 by glutamic acid, in a patient with cytochrome b positive X-linked chronic granulomatous disease. (8101486)
1993
24
Missense mutations in the beta-myosin heavy-chain gene cause central core disease in hypertrophic cardiomyopathy. (8483915)
1993
25
Gamma-1 heavy chain disease with the demonstration of Bence-Jones proteins]. (1916871)
1991
26
Cutaneous manifestations associated with gamma heavy chain disease. Report of an unusual case and review of literature. (2121807)
1990
27
A new extra sequence at the amino terminal of a mu heavy chain disease protein (DAG). (2119480)
1990
28
Immunochemical and structural characterization of an IgG1 heavy chain disease. (2503864)
1989
29
Gamma heavy chain disease and rheumatoid arthritis. (2658067)
1989
30
Genomic alterations in a case of alpha heavy chain disease leading to the generation of composite exons from the JH region. (2513209)
1989
31
Molecular analysis of a t(9;14)(p11;q32) translocation occurring in a case of human alpha heavy chain disease. (2498807)
1989
32
Alpha-heavy-chain disease with erythematous skin lesions. (3096219)
1986
33
Gamma 3 heavy chain disease and monoclonal IgMk in a patient with a gastrointestinal lymphoma. (3924773)
1985
34
Two cases of alpha heavy chain disease in Venezuelans. (6442911)
1984
35
Gamma heavy chain disease. Where the heavy chains arise. (6404156)
1983
36
Biochemical and biosynthetic studies of a crystallizable human gamma 1 heavy-chain disease protein. (6410498)
1983
37
Gamma heavy chain disease in man: cDNA sequence supports partial gene deletion model. (6808505)
1982
38
The diverse picture of gamma heavy-chain disease. Report of seven cases and review of literature. (6789012)
1981
39
Two alpha heavy chain disease proteins with different genomic deletions demonstrate that nonexpressed alpha heavy chain genes contain methylated bases. (6273910)
1981
40
Gamma heavy chain disease seen initially as gastric neoplasm. (96746)
1978
41
A new case of gamma-heavy chain disease. (417549)
1978
42
Gamma heavy chain disease: clinical aspects and characterization of a deleted, noncovalently linked gamma1 heavy chain dimer (BAZ). (402960)
1977
43
Gamma heavy chain disease--presenting as pancytopenia and splenomegaly. (403613)
1977
44
Giemsa-SEM method to observe the surface structure of plasmocytoid cell in a heavy chain disease. (1025231)
1976
45
The amino acid sequence of 'heavy chain disease' protein ZUC. Structure of the Fc fragment of immunoglobulin G3. (823945)
1976
46
Gamma heavy chain disease: rapid, sustained response to cyclophosphamide and prednisone. (1131420)
1975
47
Primary intestinal lymphoma and its relation to alpha heavy chain disease. (810150)
1975
48
Heavy chain disease. (5025909)
1972
49
Two cases of IgG heavy-chain disease. (5356509)
1969
50
HEAVY CHAIN DISEASE- A NEW DISORDER OF SERUM GAMMA-GLOBULINS : REPORT OF THE FIRST CASE. (14209281)
1964

Genetic Variations for Heavy Chain Disease

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Expression for genes affiliated with Heavy Chain Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Heavy Chain Disease

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Pathways for genes affiliated with Heavy Chain Disease

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Compounds for genes affiliated with Heavy Chain Disease

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44Novoseek, 24HMDB
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Compounds related to Heavy Chain Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1thyroxine44 2410.3SLC3A2, CD79A

GO Terms for genes affiliated with Heavy Chain Disease

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Products for genes affiliated with Heavy Chain Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Heavy Chain Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet