HCD
MCID: HVY001
MIFTS: 35

Heavy Chain Disease (HCD) malady

Blood diseases, Cancer diseases categories

Summaries for Heavy Chain Disease

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Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A hypersensitivity reaction type iv disease that results from a proliferation of cells producing immunoglobulin heavy chains.

MalaCards: Heavy Chain Disease, also known as HCD, is related to gamma heavy chain disease and alpha chain disease. An important gene associated with Heavy Chain Disease is IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker)). The compound thyroxine have been mentioned in the context of this disorder. Affiliated tissues include small intestine, skeletal muscle and heart.

Wikipedia:63 Heavy chain disease is a form of paraproteinemia with a proliferation of cells producing immunoglobulin... more...

Aliases & Classifications for Heavy Chain Disease

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Sources:
8Disease Ontology, 10DISEASES, 48Orphanet, 60UMLS, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Blood diseases


Characteristics (Orphanet epidemiological data):

48
heavy chain disease:
Age of onset: Adulthood


Aliases & Descriptions:

heavy chain disease 8 10 48 60
hcd 48


External Ids:

Disease Ontology8 DOID:0060125
MeSH34 D006362
MESH via Orphanet35 D006362
ICD10 via Orphanet26 C88.2, C88.3
SNOMED-CT via Orphanet57 6381009, 68979007
UMLS via Orphanet61 C0018852

Related Diseases for Heavy Chain Disease

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Heavy Chain Disease:



Diseases related to heavy chain disease

Clinical Features for Heavy Chain Disease

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Drugs & Therapeutics for Heavy Chain Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Heavy Chain Disease

Drug clinical trials:

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Search NIH Clinical Center for Heavy Chain Disease

Search CenterWatch for Heavy Chain Disease

Genetic Tests for Heavy Chain Disease

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Anatomical Context for Heavy Chain Disease

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Sources:
32MalaCards
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MalaCards organs/tissues related to Heavy Chain Disease:

32
Small intestine, Skeletal muscle, Heart, Testes, Skin, Thyroid, T cells, B cells, Kidney, Lymph node, Lung, Liver

Animal Models for Heavy Chain Disease or affiliated genes

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Publications for Heavy Chain Disease

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Sources:
50PubMed
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Articles related to Heavy Chain Disease:

(show top 50)    (show all 257)
idTitleAuthorsYear
1
Heavy chain deposition disease: an overview. (23652830)
2013
2
High-dose melphalan followed by auto-SCT has favorable safety and efficacy in selected patients with light chain deposition disease and light and heavy chain deposition disease. (21499318)
2012
3
Gamma heavy chain disease in a patient with underlying lymphoplasmacytic lymphoma of the thyroid. Report of a case and comparison with other reported cases with thyroid involvement. (22561184)
2012
4
Mice with mutation in dynein heavy chain 1 do not share the same tau expression pattern with mice with SOD1-related motor neuron disease. (21380844)
2011
5
Human disease caused by loss of fast IIa myosin heavy chain due to recessive MYH2 mutations. (20418530)
2010
6
Heavy chain myosin 9-related disease (MYH9 -RD): neutrophil inclusions of myosin-9 as a pathognomonic sign of the disorder. (20174760)
2010
7
Deficiency of ferritin heavy-chain nuclear import in triple a syndrome implies nuclear oxidative damage as the primary disease mechanism. (19855093)
2009
8
Nonmuscle myosin heavy chain 9 gene mutations related disease: a family report]. (18458691)
2008
9
Multiple extranodal tumors in mu-heavy chain disease. (17050207)
2006
10
High dose chemotherapy in light chain or light and heavy chain deposition disease. (14717936)
2004
11
Mu-heavy chain disease associated with systemic amyloidosis. (15203869)
2004
12
Minimal residual disease detection in hairy cell leukemia. Comparison of flow cytometric immunophenotyping with clonal analysis using consensus primer polymerase chain reaction for the heavy chain gene. (12579991)
2003
13
Generalized cutis laxa associated with heavy chain deposition disease. (14973644)
2003
14
Gamma-heavy chain disease: review of 23 cases. (12861101)
2003
15
Immunoglobulin gene rearrangement analysis in composite hodgkin disease and large B-cell lymphoma: evidence for receptor revision of immunoglobulin heavy chain variable region genes in Hodgkin-Reed-Sternberg cells? (11854595)
2002
16
Heavy chain deposition disease: recurrence in a renal transplant and report of IgG(2) subtype. (10793054)
2000
17
The amino acid sequence of a monoclonal gamma 3-heavy chain from a patient with articular gamma-heavy chain deposition disease. (10849371)
2000
18
Non-amyloid fibrils in heavy chain deposition disease. (10504516)
1999
19
A 25-kb deletion in the 5' region of the cytochrome b558 heavy chain gene (CYBB) in a patient with X-linked chronic granulomatous disease. (9099835)
1997
20
Pre-B-cell development in the absence of lambda 5 in transgenic mice expressing a heavy-chain disease protein. (8548286)
1995
21
Primary SjAPgren's syndrome and gamma heavy chain disease. (7991295)
1994
22
Alpha heavy chain disease alpha mRNA contain nucleotide sequences of unknown origins. (1425927)
1992
23
IgG heavy-chain subclass restriction of thyrotropin-binding inhibitory immunoglobulins in Graves' disease. (1977589)
1990
24
A missense mutation in the neutrophil cytochrome b heavy chain in cytochrome-positive X-linked chronic granulomatous disease. (2556453)
1989
25
Rapid evolution in the immunochemical findings of a gamma heavy chain disease. (3124986)
1988
26
Cutaneous lesions in gamma heavy-chain disease. (3138950)
1988
27
A pre-translational defect in a case of human mu heavy chain disease. (3099178)
1986
28
Hypercalcemia and reversible renal failure in heavy-chain disease. (3085235)
1986
29
Alpha heavy chain disease: report of two cases. (3937780)
1985
30
Gamma heavy-chain disease involving upper airway. (3932940)
1985
31
Alpha heavy-chain disease presenting as goiter. (6431799)
1984
32
Abnormal chromosomal marker (D14 q+) in a patient with alpha heavy chain disease. (6767755)
1980
33
Primary structure of human gamma 3 immunoglobulin deletion mutant: gamma 3 heavy-chain disease protein Wis. (6774747)
1980
34
A new case of gamma heavy chain disease: clinical, immunochemical and structural characterization. (91266)
1979
35
Human heavy chain disease protein WIS: implications for the organization of immunoglobulin genes. (106391)
1979
36
The immunoselection technic in laboratory diagnosis of alpha heavy-chain disease. (110138)
1979
37
Murine heavy chain disease. (95958)
1978
38
Gamma heavy chain disease in man: synthesis of a deleted gamma3 immunoglobulin by lymphoid cells in short and long term tissue culture. (80297)
1978
39
Gamma heavy chain disease in man: translation and partial purification of mRNA coding for the deleted protein. (105356)
1978
40
The defect in mu heavy chain disease protein GLI. (815437)
1976
41
Mu heavy-chain disease--a defect in immunoglobulin assembly. Structural studies of the kappa chain. (824712)
1976
42
IgA heavy chain disease. A case detected in the western hemisphere. (1115076)
1975
43
Alpha heavy chain disease. (1148399)
1975
44
A new case of mu heavy chain disease: clinical and immunochemical studies. (4206914)
1974
45
The catabolism of human G immunoglobulins of different heavy chain subclasses. 3. The catabolism of heavy chain disease proteins and of Fc fragments of myeloma proteins. (4624553)
1972
46
Gamma heavy chain disease. Reports of three patients. (4562896)
1972
47
The molecular defect in a protein (CRA) found in gamma-1 heavy chain disease, and its genetic implications. (4100047)
1971
48
A new variant of heavy-chain disease (mu-chain disease). (5438427)
1970
49
Metabolic studies of a heavy chain disease protein. (5803791)
1969
50
HEAVY-CHAIN DISEASE. (14255250)
1965

Genetic Variations for Heavy Chain Disease

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Expression for genes affiliated with Heavy Chain Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Heavy Chain Disease

Search GEO for disease gene expression data for Heavy Chain Disease.

Pathways for genes affiliated with Heavy Chain Disease

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Compounds for genes affiliated with Heavy Chain Disease

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Sources:
44Novoseek, 24HMDB
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Compounds related to Heavy Chain Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1thyroxine44 2410.3SLC3A2, CD79A

GO Terms for genes affiliated with Heavy Chain Disease

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Products for genes affiliated with Heavy Chain Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Heavy Chain Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet