HCD
MCID: HVY001
MIFTS: 39

Heavy Chain Disease (HCD) malady

Blood diseases, Cancer diseases, Rare diseases, Immune diseases, Gastrointestinal diseases categories
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Summaries for Heavy Chain Disease

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Disease Ontology:8 A hypersensitivity reaction type iv disease that results from a proliferation of cells producing immunoglobulin heavy chains.

MalaCards: Heavy Chain Disease, also known as HCD, is related to gamma heavy chain disease and alpha heavy-chain disease. An important gene associated with Heavy Chain Disease is IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker)). The compounds agar and thyroxine have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and thyroid.

Wikipedia:65 Heavy chain disease is a form of paraproteinemia with a proliferation of cells producing immunoglobulin... more...

Aliases & Classifications for Heavy Chain Disease

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8Disease Ontology, 10DISEASES, 49Orphanet, 62UMLS, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

49
heavy chain disease:
Age of onset: Adulthood


Aliases & Descriptions:

heavy chain disease 8 10 49 62
hcd 49


External Ids:

Disease Ontology8 DOID:0060125
MeSH35 D006362
MESH via Orphanet36 D006362
ICD10 via Orphanet26 C88.2, C88.3
SNOMED-CT via Orphanet59 6381009, 68979007
UMLS via Orphanet63 C0018852

Related Diseases for Heavy Chain Disease

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Heavy Chain Disease:



Diseases related to heavy chain disease

Symptoms for Heavy Chain Disease

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Drugs & Therapeutics for Heavy Chain Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Heavy Chain Disease

Search NIH Clinical Center for Heavy Chain Disease

Genetic Tests for Heavy Chain Disease

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Anatomical Context for Heavy Chain Disease

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33MalaCards
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MalaCards organs/tissues related to Heavy Chain Disease:

33
Small intestine, Testes, Thyroid, T cells, Lymph node, Skin, B cells

Animal Models for Heavy Chain Disease or affiliated genes

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Publications for Heavy Chain Disease

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Sources:
52PubMed
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Articles related to Heavy Chain Disease:

(show top 50)    (show all 177)
idTitleAuthorsYear
1
Analysis of patients with I^-heavy chain disease by the heavy/light chain and free light chain assays. (24327529)
2013
2
Gamma heavy-chain disease: defining the spectrum of associated lymphoproliferative disorders through analysis of 13 cases. (22301495)
2012
3
Unusual gamma heavy chain disease protein in a patient with splenic marginal-zone lymphoma. (16536920)
2006
4
Composite nodular lymphocyte-predominance Hodgkin disease and gamma-heavy-chain disease: a case report and review of the literature. (11371236)
2001
5
Is there a pathogenic link between gamma heavy chain disease and chronic arthritis? (10647957)
2000
6
Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease. (9482908)
1998
7
Chronic arthritis and gamma heavy chain disease: coincidence or pathogenic link? (9751465)
1998
8
A case of mu-heavy chain disease: combined features of mu-chain disease and macroglobulinemia. (9401282)
1997
9
Pre-B-cell development in the absence of lambda 5 in transgenic mice expressing a heavy-chain disease protein. (8548286)
1995
10
Malabsorption associated with a high-grade-malignant non-Hodgkin's lymphoma, alpha-heavy-chain disease and immunoproliferative small intestinal disease. (7793120)
1995
11
Free fragments of gamma chain in the urine. A possible source of confusion with gamma heavy-chain disease. (8160637)
1994
12
Atrophie blanche in a patient with gamma-heavy-chain disease. (1899331)
1991
13
Cutaneous manifestations associated with gamma heavy chain disease. Report of an unusual case and review of literature. (2121807)
1990
14
A new extra sequence at the amino terminal of a mu heavy chain disease protein (DAG). (2119480)
1990
15
Immunochemical and structural characterization of an IgG1 heavy chain disease. (2503864)
1989
16
Gamma heavy chain disease and rheumatoid arthritis. (2658067)
1989
17
Gamma heavy chain disease in man. Genomic sequence reveals two noncontiguous deletions in a single gene. (3139711)
1988
18
Elevated serum IgA associated with immunoproliferative enteropathy of Basenji dogs: lack of evidence for alpha heavy-chain disease or enhanced intestinal IgA secretion. (3149068)
1988
19
Alpha heavy chain disease: report of two cases. (3937780)
1985
20
Gamma heavy chain disease DUB: clinical, immunochemical and pathological studies. (3932151)
1985
21
Plasma cell infiltration of the small bowel: lack of evidence for a non-secretory form of alpha-heavy chain disease. (3928450)
1985
22
Crystals of the human heavy chain disease protein Riv and human Fc fragment are isomorphous: further evidence for conformational flexibility in the hinge region of immunoglobulins. (6405046)
1983
23
The diverse picture of gamma heavy-chain disease. Report of seven cases and review of literature. (6789012)
1981
24
The pathology of gamma heavy chain disease: report of a case with morphologic progression from lymphocytic to plasmacytic proliferation. (6790158)
1981
25
Abnormal chromosomal marker (D14 q+) in a patient with alpha heavy chain disease. (6767755)
1980
26
Gamma heavy chain disease with an unusually benign course. (6769634)
1980
27
IgD myeloma or delta heavy-chain disease? (6766363)
1980
28
delta-Heavy chain disease. A study of a case. (6777103)
1980
29
G1 heavy chain disease: clinicopathological, ultrastructural and immunochemical study of a new case. (6766944)
1980
30
A case of gamma 3 heavy chain disease with vacuolated plasma cells: a clinical, immunological, and ultrastructural study. (109474)
1979
31
A new case of gamma heavy chain disease: clinical, immunochemical and structural characterization. (91266)
1979
32
Murine heavy chain disease. (95958)
1978
33
An unusual case of a plasma cell neoplasm with an IgG3lambda myeloma and a gamma3 heavy chain disease protein. (412532)
1978
34
Gamma heavy chain disease in man: synthesis of a deleted gamma3 immunoglobulin by lymphoid cells in short and long term tissue culture. (80297)
1978
35
Pathological studies on a long-term survived case of gamma heavy chain disease--a brief review of 30 reported cases and a proposal for histological typing. (104544)
1978
36
Gamma heavy chain disease; report of an autopsy case with a review of the literatures. (822689)
1976
37
Gamma heavy chain disease in a young girl. (828123)
1976
38
N- and C-terminal amino acid sequences of a gamma-heavy chain disease protein YOK. (819357)
1976
39
A case of gamma heavy chain disease associated with autoimmune haemolytic anaemia: clinical, haematological, immunological and pathological details. (821137)
1976
40
The defect in mu heavy chain disease protein GLI. (815437)
1976
41
Gamma heavy chain disease: rapid, sustained response to cyclophosphamide and prednisone. (1131420)
1975
42
In vitro production of an amyloid-like substance from gamma 3 heavy chain disease protein. (4609897)
1974
43
A new case of mu heavy chain disease: clinical and immunochemical studies. (4206914)
1974
44
Determination of the light chain type of paraproteins, identification of heavy chain disease. (4213025)
1972
45
Alpha heavy chain disease. A variant of Mediterranean lymphoma. (5093214)
1971
46
Immunoglobulin M heavy chain disease: intracellular origin of the mu chain fragment. (5464612)
1970
47
A new variant of heavy-chain disease (mu-chain disease). (5438427)
1970
48
Implications of heavy chain disease protein sequences for multiple gene theories of immunoglobulin synthesis. (4194868)
1970
49
Heavy-chain disease. (4171785)
1968
50
HEAVY CHAIN DISEASE- A NEW DISORDER OF SERUM GAMMA-GLOBULINS : REPORT OF THE FIRST CASE. (14209281)
1964

Variations for Heavy Chain Disease

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Expression for genes affiliated with Heavy Chain Disease

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Heavy Chain Disease

Search GEO for disease gene expression data for Heavy Chain Disease.

Pathways for genes affiliated with Heavy Chain Disease

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Compounds for genes affiliated with Heavy Chain Disease

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45Novoseek, 24HMDB
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Compounds related to Heavy Chain Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1agar459.4SLC3A2, CD79A
2thyroxine45 2410.3SLC3A2, CD79A
3phenylalanine459.2SLC3A2, PNMT

GO Terms for genes affiliated with Heavy Chain Disease

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16Gene Ontology
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Biological processes related to Heavy Chain Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to exogenous dsRNAGO:0433309.1SLC3A2, DDX1

Molecular functions related to Heavy Chain Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1double-stranded RNA bindingGO:0037259.1SLC3A2, DDX1

Products for genes affiliated with Heavy Chain Disease

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Heavy Chain Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet