HCD
MCID: HVY001
MIFTS: 27

Heavy Chain Disease (HCD) malady

Blood, Cancer categories

Summaries for Heavy Chain Disease

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A hypersensitivity reaction type iv disease that results from a proliferation of cells producing immunoglobulin heavy chains.

MalaCards: Heavy Chain Disease, also known as HCD, is related to gamma heavy chain disease and alpha chain disease. An important gene associated with Heavy Chain Disease is IGHG3 (immunoglobulin heavy constant gamma 3 (G3m marker)). The compound thyroxine have been mentioned in the context of this disorder.

Wikipedia:64 Heavy chain disease is a form of paraproteinemia with a proliferation of cells producing immunoglobulin... more...

Aliases & Classifications for Heavy Chain Disease

Sources:
8Disease Ontology, 10DISEASES, 49Orphanet, 61UMLS, 35MeSH, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Blood


Characteristics (Orphanet epidemiological data):

49
heavy chain disease:
Age of onset: Adulthood


Aliases & Descriptions:

heavy chain disease 8 10 49 61
hcd 49


External Ids:

Disease Ontology8 DOID:0060125
MeSH35 D006362
MESH via Orphanet36 D006362
ICD10 via Orphanet26 C88.2, C88.3
SNOMED-CT via Orphanet58 6381009, 68979007
UMLS via Orphanet62 C0018852

Related Diseases for Heavy Chain Disease

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Heavy Chain Disease:



Diseases related to heavy chain disease

Clinical Features for Heavy Chain Disease

Drugs & Therapeutics for Heavy Chain Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Heavy Chain Disease

Drug clinical trials:

Search ClinicalTrials for Heavy Chain Disease

Search NIH Clinical Center for Heavy Chain Disease

Search CenterWatch for Heavy Chain Disease

Genetic Tests for Heavy Chain Disease

Anatomical Context for Heavy Chain Disease

Animal Models for Heavy Chain Disease or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Heavy Chain Disease

Sources:
51PubMed
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Articles related to Heavy Chain Disease:

(show top 50)    (show all 270)
idTitleAuthorsYear
1
Proliferative glomerulonephritis with discrete deposition of monoclonal immunoglobulin I^1 CH 2 heavy chain and I_ light chain: a new variant of monoclonal immunoglobulin deposition disease. (23356227)
2013
2
Gamma heavy-chain disease: defining the spectrum of associated lymphoproliferative disorders through analysis of 13 cases. (22301495)
2012
3
Successful treatment of I^-heavy-chain disease with rituximab and fludarabine. (22890122)
2012
4
Serum immunoglobulin free light chain measurements and heavy chain isotype usage provide insight into disease biology in patients with POEMS syndrome. (20513121)
2010
5
Heavy chain myosin 9-related disease (MYH9 -RD): neutrophil inclusions of myosin-9 as a pathognomonic sign of the disorder. (20174760)
2010
6
Unusual gamma heavy chain disease protein in a patient with splenic marginal-zone lymphoma. (16536920)
2006
7
Effects of exercise and creatine on myosin heavy chain isoform composition in patients with Charcot-Marie-Tooth disease. (16881064)
2006
8
Detection of heavy chain disease by capillary zone electrophoresis. (15976121)
2005
9
Nodal marginal-zone lymphoma associated with monoclonal light-chain and heavy-chain deposition disease. (15172359)
2004
10
Immunoglobulin gamma3-heavy-chain deposition disease: report of a case and relationship with hypocomplementemia. (14712467)
2004
11
Articular, monoclonal gamma3 heavy-chain deposition disease: characterization of a partially deleted heavy-chain gene and its protein product synthesized in vivo and in vitro. (14613292)
2003
12
Regarding: "Expression of myosin heavy chain isoforms in skeletal muscle of patients with peripheral arterial occlusive disease". (10709078)
2000
13
Test and teach. Number One hundred and four. Mu heavy chain disease (mu-HCD). (10968396)
2000
14
The amino acid sequence of a monoclonal gamma 3-heavy chain from a patient with articular gamma-heavy chain deposition disease. (10849371)
2000
15
Alpha-heavy chain disease, Mediterranean lymphoma, and immunoproliferative small intestinal disease: a review of clinicopathological features, pathogenesis, and differential diagnosis. (10235185)
1999
16
Frequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain disease. (9482908)
1998
17
Malabsorption associated with a high-grade-malignant non-Hodgkin's lymphoma, alpha-heavy-chain disease and immunoproliferative small intestinal disease. (7793120)
1995
18
Structure of abnormal heavy chains in human heavy-chain-deposition disease. (7744049)
1995
19
Biological diagnosis of a gamma-1-heavy chain disease in an asymptomatic patient. (7720844)
1995
20
Free fragments of gamma chain in the urine. A possible source of confusion with gamma heavy-chain disease. (8160637)
1994
21
Modified immunoselection technique for definitive diagnosis of heavy-chain disease. (8149622)
1994
22
Working capacity and expression of myosin heavy chain isoforms in skeletal muscle of chronic alcoholic men without liver disease after 1 day and 4 weeks of alcohol abstinence. (8168338)
1994
23
IgG heavy-chain deposition disease. (7838842)
1994
24
Coexpression of alpha and beta myosin heavy-chain isoforms in atria of neonates and infants with congenital heart disease. (8240229)
1993
25
Brief report: heavy-chain deposition disease. (8413435)
1993
26
Missense mutations in the beta-myosin heavy-chain gene cause central core disease in hypertrophic cardiomyopathy. (8483915)
1993
27
Mechanisms of disease: monoclonal immunoglobulin deposition. Amyloidosis, light chain deposition disease, and light and heavy chain deposition disease. (1582976)
1992
28
Atrophie blanche in a patient with gamma-heavy-chain disease. (1899331)
1991
29
Gamma-1 heavy chain disease with the demonstration of Bence-Jones proteins]. (1916871)
1991
30
Gamma heavy chain disease associated with Hodgkin's disease. Clinical, pathologic, and immunologic features of one case. (2495168)
1989
31
Gamma heavy chain disease in man. Genomic sequence reveals two noncontiguous deletions in a single gene. (3139711)
1988
32
Cutaneous lesions in gamma heavy-chain disease. (3138950)
1988
33
Alpha-heavy-chain disease with erythematous skin lesions. (3096219)
1986
34
Gamma 3 heavy chain disease and monoclonal IgMk in a patient with a gastrointestinal lymphoma. (3924773)
1985
35
Two cases of alpha heavy chain disease in Venezuelans. (6442911)
1984
36
Gamma heavy chain disease. Where the heavy chains arise. (6404156)
1983
37
Gamma heavy chain disease. Ultrastructural and immunohistochemical study. (6414241)
1983
38
Gamma heavy chain disease and giant lymph node hyperplasia in a patient with impaired T cell function. (6811785)
1982
39
Chronic lymphocytic leukaemia and IgG heavy chain disease. (7008181)
1980
40
Correlation of protein structure and immunoglobulin gene organization in the light of two new deleted heavy chain disease proteins. (118919)
1979
41
An unusual case of a plasma cell neoplasm with an IgG3lambda myeloma and a gamma3 heavy chain disease protein. (412532)
1978
42
A new case of gamma-heavy chain disease. (417549)
1978
43
Giemsa-SEM method to observe the surface structure of plasmocytoid cell in a heavy chain disease. (1025231)
1976
44
Primary intestinal lymphoma and its relation to alpha heavy chain disease. (810150)
1975
45
Alpha heavy chain disease. (1148399)
1975
46
Determination of the light chain type of paraproteins, identification of heavy chain disease. (4213025)
1972
47
Heavy chain disease. Report of a case. (5053312)
1972
48
Alpha heavy chain disease. A variant of Mediterranean lymphoma. (5093214)
1971
49
Two cases of "heavy chain disease". (5283067)
1971
50
Immunoglobulin M heavy chain disease: intracellular origin of the mu chain fragment. (5464612)
1970

Genetic Variations for Heavy Chain Disease

Expression for genes affiliated with Heavy Chain Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Heavy Chain Disease

Search GEO for disease gene expression data for Heavy Chain Disease.

Pathways for genes affiliated with Heavy Chain Disease

Compounds for genes affiliated with Heavy Chain Disease

Sources:
45Novoseek, 24HMDB
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Compounds related to Heavy Chain Disease according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1thyroxine45 2410.3SLC3A2, CD79A

GO Terms for genes affiliated with Heavy Chain Disease

Products for genes affiliated with Heavy Chain Disease

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Heavy Chain Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet