MCID: HVY002
MIFTS: 22

Heavy Metal Poisoning

Categories: Rare diseases

Aliases & Classifications for Heavy Metal Poisoning

MalaCards integrated aliases for Heavy Metal Poisoning:

Name: Heavy Metal Poisoning 49
Chronic Heavy Metal Poisoning 49
Heavy Metal Toxicity 49

Classifications:



Summaries for Heavy Metal Poisoning

NIH Rare Diseases : 49 Heavy metal poisoning refers to when excessive exposure to a heavy metal affects the normal function of the body. Examples of heavy metals that can cause toxicity include lead, mercury, arsenic, cadmium, and chromium. Exposure may occur through the diet, from medications, from the environment, or in the course of work or play. Heavy metals can enter the body through the skin, or by inhalation or ingestion. Toxicity can result from sudden, severe exposure, or from chronic exposure over time. Symptoms can vary depending on the metal involved, the amount absorbed, and the age of the person exposed. For example, young children are more susceptible to the effects of lead exposure because they absorb more compared with adults and their brains are still developing. Nausea, vomiting, diarrhea, and abdominal pain are common symptoms of acute metal ingestion. Chronic exposure may cause various symptoms resulting from damage to body organs, and may increase the risk of cancer. Treatment depends on the circumstances of the exposure. Last updated: 4/28/2017

MalaCards based summary : Heavy Metal Poisoning, also known as chronic heavy metal poisoning, is related to blood group--diego system and blood group, i system. The drugs Iron and Chelating Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and kidney.

Related Diseases for Heavy Metal Poisoning

Diseases related to Heavy Metal Poisoning via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 blood group--diego system 9.9
2 blood group, i system 9.9
3 creutzfeldt-jakob disease 9.9
4 porphyria variegata 9.9
5 glass syndrome 9.9
6 porphyria 9.9
7 mercury poisoning 9.9
8 neurosyphilis 9.9

Graphical network of the top 20 diseases related to Heavy Metal Poisoning:



Diseases related to Heavy Metal Poisoning

Symptoms & Phenotypes for Heavy Metal Poisoning

Drugs & Therapeutics for Heavy Metal Poisoning

Drugs for Heavy Metal Poisoning (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4,Phase 2 7439-89-6 23925
2 Chelating Agents Phase 4,Phase 1,Phase 2
3 Antidotes Phase 4,Phase 1,Phase 2
4 Protective Agents Phase 4,Phase 3,Phase 1,Phase 2
5
Selenium Approved, Investigational, Vet_approved Phase 3,Phase 1,Phase 2 7782-49-2
6
Selenious acid Approved, Investigational Phase 3,Phase 1,Phase 2 7783-00-8
7 Micronutrients Phase 3,Phase 2,Phase 1
8 Trace Elements Phase 3,Phase 2,Phase 1
9 Sodium Selenite Phase 3,Phase 1,Phase 2
10 Antioxidants Phase 3,Phase 2,Phase 1
11
Salicylic acid Approved, Investigational, Vet_approved Phase 2 69-72-7 338
12
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
13
Succimer Approved Phase 1, Phase 2 304-55-2 9354
14
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
15
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
16 Tocopherol Approved, Investigational, Nutraceutical Phase 2
17
Vitamin E Approved, Nutraceutical, Vet_approved Phase 2 59-02-9 14985
18 Garlic Approved, Nutraceutical Phase 2
19 Hematinics Phase 2
20 Vitamin B Complex Phase 2
21 Vitamins Phase 2
22 Analgesics Phase 2
23 Salicylates Phase 2
24 Allyl sulfide Phase 2
25 Tocopherols Phase 2
26 Tocotrienols Phase 2
27 Cyclooxygenase Inhibitors Phase 2
28 Analgesics, Non-Narcotic Phase 2
29 Cytochrome P-450 Enzyme Inhibitors Phase 2
30 Dermatologic Agents Phase 2
31 Peripheral Nervous System Agents Phase 2
32 Pharmaceutical Solutions Phase 1, Phase 2
33 Anti-Infective Agents Phase 2
34 Antifungal Agents Phase 2
35 Anti-Inflammatory Agents Phase 2
36 Anti-Inflammatory Agents, Non-Steroidal Phase 2
37 Keratolytic Agents Phase 2
38 Antirheumatic Agents Phase 2
39 Folate Nutraceutical Phase 2
40 Vitamin B9 Nutraceutical Phase 2
41 Tocotrienol Investigational, Nutraceutical Phase 2 6829-55-6
42 Neem Nutraceutical Phase 2
43 Diallyl Sulfide Nutraceutical Phase 2
44 Iron Supplement Nutraceutical Phase 2
45
Zinc Approved, Investigational 7440-66-6 32051 23994
46 Angiogenesis Inducing Agents
47 Angiogenesis Inhibitors
48 Angiogenesis Modulating Agents
49 Angiostatins
50 Endostatins 71581480

Interventional clinical trials:

(show all 15)

# Name Status NCT ID Phase Drugs
1 Prolonged Gadolinium Retention After MRI Imaging Withdrawn NCT02421029 Phase 4 edetate calcium disodium
2 Selenium in the Treatment of Arsenic Toxicity and Cancers Completed NCT01442727 Phase 3 sodium selenite;placebo
3 Effects of Folic Acid Supplementation on Arsenic Lowering Unknown status NCT02235948 Phase 2 folic acid supplementation
4 Dimercaptosuccinic Acid (DMSA) Treatment of Children With Autism and Heavy Metal Toxicity Completed NCT00811083 Phase 1, Phase 2 DMSA - dimercaptosuccinic acid
5 Effect of Iron and Folic Acid on Skin Fungal Pattern in Patients With Arsenicosis Completed NCT02908581 Phase 2 Placebo;Iron 150 mg and Folic acid 0.5 mg
6 Effect of Vitamin E on Skin Aerobic Bacteria in Palmar Arsenical Keratosis Completed NCT02468518 Phase 2 Vitamin E capsule
7 Selenium and Arsenic Pharmacodynamics Completed NCT02377635 Phase 1, Phase 2
8 Effect of Neem Extract, Propylene Glycol and Salicylic Acid Combination in the Treatment of Arsenical Palmar Keratosis Completed NCT02352987 Phase 2 Neem plus propylene glycol plus salicylic acid;Salicylic acid
9 Effectiveness of Garlic Oil in the Treatment of Arsenical Palmer Keratosis Completed NCT01748669 Phase 2
10 Effect of Cock's Comb Extract in the Treatment of Arsenical Skin Lesion Recruiting NCT03127657 Phase 2 Cock's comb extract 0.01%
11 Heavy Metals, Angiogenesis Factors and Osteopontin in Coronary Artery Disease (CAD) Completed NCT02159235
12 High-selenium Lentils Versus Arsenic Toxicity Completed NCT02429921
13 Vitamin E Level in Buccal Cells of Arsenicosis Patients Completed NCT01743066
14 Modulation of Anaerobic Gut Bacteria of Arsenicosis Patients by Probiotics Completed NCT01726426
15 the Association Between Blood's and Urinary Heavy Metal Level in Pregnant Women and the Spontaneous Abortion Recruiting NCT03332706

Search NIH Clinical Center for Heavy Metal Poisoning

Genetic Tests for Heavy Metal Poisoning

Anatomical Context for Heavy Metal Poisoning

MalaCards organs/tissues related to Heavy Metal Poisoning:

38
Skin, Brain, Kidney

Publications for Heavy Metal Poisoning

Articles related to Heavy Metal Poisoning:

(show all 44)
# Title Authors Year
1
Enzyme immobilization on a nanoadsorbent for improved stability against heavy metal poisoning. ( 27085045 )
2016
2
Study of heavy metal poisoning in frequent users of Chinese medicines in Hong Kong and Macau. ( 22899484 )
2013
3
Heavy metal poisoning should be recognized as a cause of hypertension in children. ( 22963055 )
2012
4
Heavy metal poisoning and cardiovascular disease. ( 21912545 )
2011
5
Heavy metal poisoning: the effects of cadmium on the kidney. ( 20354761 )
2010
6
Use of total reflection X-ray fluorescence (TXRF) for the evaluation of heavy metal poisoning due to the improper use of a traditional ayurvedic drug. ( 20304577 )
2010
7
Heavy metal poisoning: management of intoxication and antidotes. ( 20358690 )
2010
8
Animal health problems attributed to environmental contamination in lake Nakuru National Park, Kenya: a case study on heavy metal poisoning in the Waterbuck Kobus ellipsiprymnus defassa (Ruppel 1835). ( 17160492 )
2007
9
Heavy metal poisoning: clinical presentations and pathophysiology. ( 16567226 )
2006
10
Use of hair analysis in the diagnosis of heavy metal poisoning: report of three cases. ( 15181225 )
2004
11
Use of hair analysis in diagnosing heavy metal poisoning. ( 15479971 )
2004
12
Creutzfeldt-Jakob disease (CJD) in a case of suspected chronic heavy metal poisoning. ( 11373012 )
2001
13
Heavy metal poisoning in glass worker characterised by severe. ( 10865245 )
2000
14
Integrating data from legacy systems using object linking and embedding technology: development of a reporting system for heavy metal poisoning results. ( 10887164 )
2000
15
Heavy metal poisoning and its laboratory investigation. ( 10376071 )
1999
16
Neurosyphilis, or chronic heavy metal poisoning: Karen Blixen's lifelong disease. ( 7544495 )
1995
17
Metallothionein and heavy metal poisoning. ( 7821512 )
1994
18
Arsenic, an old case: the chronic heavy metal poisoning of Raphaelle Peale (1774-1825). ( 8361847 )
1993
19
An unusual case of heavy metal poisoning. ( 8300496 )
1993
20
Selenium in the treatment of heavy metal poisoning and chemical carcinogenesis. ( 1304229 )
1992
21
Heavy metal poisoning in ostriches from proventricular foreign bodies. ( 1609502 )
1992
22
2,3-Dimercaptosuccinic acid treatment of heavy metal poisoning in humans. ( 2851085 )
1988
23
Hematologic effects of heavy metal poisoning. ( 3047880 )
1988
24
Heavy metal poisoning. ( 3358185 )
1988
25
A study on the effect of garlic to the heavy metal poisoning of rat. ( 3268178 )
1987
26
2,3-Dimercapto-1-propanesulphonate in heavy metal poisoning. ( 3312928 )
1987
27
Role of 2,3-dimercaptosuccinic acid in the treatment of heavy metal poisoning. ( 3023784 )
1986
28
Dithiocarbamates in heavy metal poisoning: complexes of N,N-di(2-hidroxyethyl)dithiocarbamate with Zn(II), Cd(II), Hg(II), CH3Hg(II), and C6H5Hg(II). ( 2995583 )
1985
29
N-Acetylcysteine therapy of acute heavy metal poisoning in mice. ( 4082467 )
1985
30
DMSA and DMPS--water soluble antidotes for heavy metal poisoning. ( 6307120 )
1983
31
Variegate porphyria and heavy metal poisoning from ingestion of "moonshine". ( 6879266 )
1983
32
A novel approach for heavy metal poisoning treatment, a model. Mercury poisoning by means of chelating microspheres: hemoperfusion and oral administration. ( 7328590 )
1981
33
Factors involved in heavy metal poisoning. ( 844608 )
1977
34
Proceedings: Heavy metal poisoning and antidotes. ( 4545734 )
1974
35
Changes of some properties of erythrocytes in workers occupationally exposed to radon and its daughter products: radiation effect or heavy metal poisoning? ( 4802426 )
1973
36
Heavy metal poisoning: clinical aspects and laboratory analysis. ( 4748720 )
1973
37
Hemolysis produced by copper sulphate. I. Extravascular hemolysis produced by heavy metal poisoning. ( 4758995 )
1973
38
Heavy metal poisoning: mercury and lead. ( 4623585 )
1972
39
Heavy metal poisoning? type. ( 13379365 )
1956
40
USE of calcium ethylenediaminetetraacetate in treating heavy-metal poisoning. ( 13007209 )
1953
41
The treatment of heavy metal poisoning with British antilewisite. ( 18117358 )
1949
42
The use of BAL in heavy metal poisoning, with particular reference to antimonial intoxication. ( 18111907 )
1948
43
The use of BAL in the treatment of heavy-metal poisoning. ( 20295051 )
1947
44
Drug reactions and their treatment, with special reference to the use of BAL in heavy metal poisoning. ( 18896226 )
1947

Variations for Heavy Metal Poisoning

Expression for Heavy Metal Poisoning

Search GEO for disease gene expression data for Heavy Metal Poisoning.

Pathways for Heavy Metal Poisoning

GO Terms for Heavy Metal Poisoning

Sources for Heavy Metal Poisoning

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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