MCID: HVY002
MIFTS: 20

Heavy Metal Poisoning malady

Categories: Rare diseases

Aliases & Classifications for Heavy Metal Poisoning

Aliases & Descriptions for Heavy Metal Poisoning:

Name: Heavy Metal Poisoning 50
Chronic Heavy Metal Poisoning 50
Heavy Metal Toxicity 50

Classifications:



Summaries for Heavy Metal Poisoning

NIH Rare Diseases : 50 heavy metal poisoning refers to when excessive exposure to a heavy metal affects the normal function of the body. examples of heavy metals that can cause toxicity include lead, mercury, arsenic, cadmium, and chromium. exposure may occur through the diet, from medications, from the environment, or in the course of work or play. heavy metals can enter the body through the skin, or by inhalation or ingestion. toxicity can result from sudden, severe exposure, or from chronic exposure over time. symptoms can vary depending on the metal involved, the amount absorbed, and the age of the person exposed. for example, young children are more susceptible to the effects of lead exposure because they absorb more compared with adults and their brains are still developing. nausea, vomiting, diarrhea, and abdominal pain are common symptoms of acute metal ingestion. chronic exposure may cause various symptoms resulting from damage to body organs, and may increase the risk of cancer. treatment depends on the circumstances of the exposure. last updated: 4/28/2017

MalaCards based summary : Heavy Metal Poisoning, also known as chronic heavy metal poisoning, is related to creutzfeldt-jakob disease and porphyria. The drugs Iron and Edetic Acid have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and kidney.

Related Diseases for Heavy Metal Poisoning

Diseases related to Heavy Metal Poisoning via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 creutzfeldt-jakob disease 9.8
2 porphyria 9.8
3 mercury poisoning 9.8
4 neurosyphilis 9.8

Symptoms & Phenotypes for Heavy Metal Poisoning

Drugs & Therapeutics for Heavy Metal Poisoning

Drugs for Heavy Metal Poisoning (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Phase 4,Phase 2 7439-89-6 23925
2
Edetic Acid Approved, Vet_approved Phase 4 60-00-4, 62-33-9 6049
3 Chelating Agents Phase 4,Phase 3,Phase 1,Phase 2
4 Protective Agents Phase 4,Phase 3,Phase 1,Phase 2
5 Antidotes Phase 4,Phase 3,Phase 1,Phase 2
6 Pentetic Acid Phase 4
7 Anticoagulants Phase 4
8 Iron Chelating Agents Phase 4
9 Bone Density Conservation Agents Phase 4
10 Calcium, Dietary Phase 4
11
Selenium Approved, Vet_approved Phase 3,Phase 1,Phase 2 7782-49-2
12
Succimer Approved Phase 3,Phase 1,Phase 2 304-55-2 9354
13 Trace Elements Phase 3,Phase 2,Phase 1
14 Micronutrients Phase 3,Phase 2,Phase 1
15 Selenious Acid Phase 3,Phase 1,Phase 2
16 Sodium Selenite Phase 3,Phase 1,Phase 2
17 Antioxidants Phase 3,Phase 2,Phase 1
18
Salicylic acid Approved, Vet_approved Phase 2 69-72-7 338
19
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
20
leucovorin Approved, Nutraceutical Phase 2 58-05-9 54575, 6560146 143
21
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
22
Vitamin E Approved, Nutraceutical, Vet_approved Phase 2 59-02-9 14985
23 Hematinics Phase 2
24 Vitamin B Complex Phase 2
25 Vitamins Phase 2
26 Analgesics Phase 2
27 Salicylates Phase 2
28 Cyclooxygenase Inhibitors Phase 2
29 Allyl sulfide Phase 2
30 Cytochrome P-450 Enzyme Inhibitors Phase 2
31 Tocopherols Phase 2
32 Tocotrienols Phase 2
33 Analgesics, Non-Narcotic Phase 2
34 Dermatologic Agents Phase 2
35 Peripheral Nervous System Agents Phase 2
36 Anti-Infective Agents Phase 2
37 Anti-Inflammatory Agents Phase 2
38 Antifungal Agents Phase 2
39 Keratolytic Agents Phase 2
40 Anti-Inflammatory Agents, Non-Steroidal Phase 2
41 Antirheumatic Agents Phase 2
42 Pharmaceutical Solutions Phase 1, Phase 2
43 Folate Nutraceutical Phase 2
44 Vitamin B9 Nutraceutical Phase 2
45 Tocopherol Nutraceutical Phase 2
46 Tocotrienol Nutraceutical Phase 2
47 Garlic Nutraceutical Phase 2
48 Neem Nutraceutical Phase 2
49 Diallyl Sulfide Nutraceutical Phase 2
50 Iron Supplement Nutraceutical Phase 2

Interventional clinical trials:

(show all 18)
id Name Status NCT ID Phase
1 Prolonged Gadolinium Retention After MRI Imaging Not yet recruiting NCT02421029 Phase 4
2 Selenium in the Treatment of Arsenic Toxicity and Cancers Completed NCT01442727 Phase 3
3 Treatment of Lead-Exposed Children Trial Completed NCT00342849 Phase 3
4 Effects of Folic Acid Supplementation on Arsenic Lowering Unknown status NCT02235948 Phase 2
5 Dimercaptosuccinic Acid (DMSA) Treatment of Children With Autism and Heavy Metal Toxicity Completed NCT00811083 Phase 1, Phase 2
6 Effect of Vitamin E on Skin Aerobic Bacteria in Palmar Arsenical Keratosis Completed NCT02468518 Phase 2
7 Effect of Neem Extract, Propylene Glycol and Salicylic Acid Combination in the Treatment of Arsenical Palmar Keratosis Completed NCT02352987 Phase 2
8 Effectiveness of Garlic Oil in the Treatment of Arsenical Palmer Keratosis Completed NCT01748669 Phase 2
9 Selenium and Arsenic Pharmacodynamics Recruiting NCT02377635 Phase 1, Phase 2
10 Effect of Cock's Comb Extract in the Treatment of Arsenical Skin Lesion Recruiting NCT03127657 Phase 2
11 Effect of Folic Acid on Skin Fungal Pattern in Patients With Arsenicosis Recruiting NCT02908581 Phase 2
12 Heavy Metals, Angiogenesis Factors and Osteopontin in Coronary Artery Disease (CAD) Completed NCT02159235
13 High-selenium Lentils Versus Arsenic Toxicity Completed NCT02429921
14 Modulation of Anaerobic Gut Bacteria of Arsenicosis Patients by Probiotics Completed NCT01726426
15 Vitamin E Level in Buccal Cells of Arsenicosis Patients Completed NCT01743066
16 Social Network Based Intervention to Reduce Lead Exposure Among Native American Children Completed NCT00011661
17 Effect of Environmental Exposures on the Egg Fertilizing Ability of Human Sperm Completed NCT00012480
18 Heavy Metal Exposure in Predicting Peripheral Neuropathy in Patients With Stage I-III Breast Cancer Undergoing Chemotherapy Completed NCT01982591

Search NIH Clinical Center for Heavy Metal Poisoning

Genetic Tests for Heavy Metal Poisoning

Anatomical Context for Heavy Metal Poisoning

MalaCards organs/tissues related to Heavy Metal Poisoning:

39
Brain, Skin, Kidney

Publications for Heavy Metal Poisoning

Articles related to Heavy Metal Poisoning:

(show all 44)
id Title Authors Year
1
Enzyme immobilization on a nanoadsorbent for improved stability against heavy metal poisoning. ( 27085045 )
2016
2
Study of heavy metal poisoning in frequent users of Chinese medicines in Hong Kong and Macau. ( 22899484 )
2013
3
Heavy metal poisoning should be recognized as a cause of hypertension in children. ( 22963055 )
2012
4
Heavy metal poisoning and cardiovascular disease. ( 21912545 )
2011
5
Heavy metal poisoning: management of intoxication and antidotes. ( 20358690 )
2010
6
Heavy metal poisoning: the effects of cadmium on the kidney. ( 20354761 )
2010
7
Use of total reflection X-ray fluorescence (TXRF) for the evaluation of heavy metal poisoning due to the improper use of a traditional ayurvedic drug. ( 20304577 )
2010
8
Animal health problems attributed to environmental contamination in lake Nakuru National Park, Kenya: a case study on heavy metal poisoning in the Waterbuck Kobus ellipsiprymnus defassa (Ruppel 1835). ( 17160492 )
2007
9
Heavy metal poisoning: clinical presentations and pathophysiology. ( 16567226 )
2006
10
Use of hair analysis in the diagnosis of heavy metal poisoning: report of three cases. ( 15181225 )
2004
11
Use of hair analysis in diagnosing heavy metal poisoning. ( 15479971 )
2004
12
Creutzfeldt-Jakob disease (CJD) in a case of suspected chronic heavy metal poisoning. ( 11373012 )
2001
13
Integrating data from legacy systems using object linking and embedding technology: development of a reporting system for heavy metal poisoning results. ( 10887164 )
2000
14
Heavy metal poisoning in glass worker characterised by severe. ( 10865245 )
2000
15
Heavy metal poisoning and its laboratory investigation. ( 10376071 )
1999
16
Neurosyphilis, or chronic heavy metal poisoning: Karen Blixen's lifelong disease. ( 7544495 )
1995
17
Metallothionein and heavy metal poisoning. ( 7821512 )
1994
18
Arsenic, an old case: the chronic heavy metal poisoning of Raphaelle Peale (1774-1825). ( 8361847 )
1993
19
An unusual case of heavy metal poisoning. ( 8300496 )
1993
20
Selenium in the treatment of heavy metal poisoning and chemical carcinogenesis. ( 1304229 )
1992
21
Heavy metal poisoning in ostriches from proventricular foreign bodies. ( 1609502 )
1992
22
Hematologic effects of heavy metal poisoning. ( 3047880 )
1988
23
2,3-Dimercaptosuccinic acid treatment of heavy metal poisoning in humans. ( 2851085 )
1988
24
Heavy metal poisoning. ( 3358185 )
1988
25
A study on the effect of garlic to the heavy metal poisoning of rat. ( 3268178 )
1987
26
2,3-Dimercapto-1-propanesulphonate in heavy metal poisoning. ( 3312928 )
1987
27
Role of 2,3-dimercaptosuccinic acid in the treatment of heavy metal poisoning. ( 3023784 )
1986
28
N-Acetylcysteine therapy of acute heavy metal poisoning in mice. ( 4082467 )
1985
29
Dithiocarbamates in heavy metal poisoning: complexes of N,N-di(2-hidroxyethyl)dithiocarbamate with Zn(II), Cd(II), Hg(II), CH3Hg(II), and C6H5Hg(II). ( 2995583 )
1985
30
DMSA and DMPS--water soluble antidotes for heavy metal poisoning. ( 6307120 )
1983
31
Variegate porphyria and heavy metal poisoning from ingestion of "moonshine". ( 6879266 )
1983
32
A novel approach for heavy metal poisoning treatment, a model. Mercury poisoning by means of chelating microspheres: hemoperfusion and oral administration. ( 7328590 )
1981
33
Factors involved in heavy metal poisoning. ( 844608 )
1977
34
Proceedings: Heavy metal poisoning and antidotes. ( 4545734 )
1974
35
Changes of some properties of erythrocytes in workers occupationally exposed to radon and its daughter products: radiation effect or heavy metal poisoning? ( 4802426 )
1973
36
Heavy metal poisoning: clinical aspects and laboratory analysis. ( 4748720 )
1973
37
Hemolysis produced by copper sulphate. I. Extravascular hemolysis produced by heavy metal poisoning. ( 4758995 )
1973
38
Heavy metal poisoning: mercury and lead. ( 4623585 )
1972
39
Heavy metal poisoning? type. ( 13379365 )
1956
40
USE of calcium ethylenediaminetetraacetate in treating heavy-metal poisoning. ( 13007209 )
1953
41
The treatment of heavy metal poisoning with British antilewisite. ( 18117358 )
1949
42
The use of BAL in heavy metal poisoning, with particular reference to antimonial intoxication. ( 18111907 )
1948
43
Drug reactions and their treatment, with special reference to the use of BAL in heavy metal poisoning. ( 18896226 )
1947
44
The use of BAL in the treatment of heavy-metal poisoning. ( 20295051 )
1947

Variations for Heavy Metal Poisoning

Expression for Heavy Metal Poisoning

Search GEO for disease gene expression data for Heavy Metal Poisoning.

Pathways for Heavy Metal Poisoning

GO Terms for Heavy Metal Poisoning

Sources for Heavy Metal Poisoning

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....