MCID: HNZ001
MIFTS: 26

Heinz Body Anemia malady

Summaries for Heinz Body Anemia

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47OMIM, 33MalaCards
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MalaCards: Heinz Body Anemia, also known as heinz body anemias, is related to heinz body anemias, beta- and heinz body anemias. An important gene associated with Heinz Body Anemia is HBA2 (hemoglobin, alpha 2), and among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and O2/CO2 exchange in erythrocytes. The compounds 23-diphosphoglycerate and hmba have been mentioned in the context of this disorder. Affiliated tissues include spleen and liver.

Description from OMIM:47 140700

Aliases & Classifications for Heinz Body Anemia

Sources:
61UMLS, 47OMIM
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Aliases & Descriptions:

heinz body anemia 47
heinz body anemias 61


Related Diseases for Heinz Body Anemia

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Heinz Body Anemia:



Diseases related to heinz body anemia

Clinical Features for Heinz Body Anemia

Sources:
47OMIM
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Clinical features from OMIM:

140700

Drugs & Therapeutics for Heinz Body Anemia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Heinz Body Anemia

Drug clinical trials:

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Genetic Tests for Heinz Body Anemia

Anatomical Context for Heinz Body Anemia

Sources:
33MalaCards
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MalaCards organs/tissues related to Heinz Body Anemia:

33
Spleen, Liver

Animal Models for Heinz Body Anemia or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Heinz Body Anemia

Sources:
51PubMed
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Articles related to Heinz Body Anemia:

(show all 16)
idTitleAuthorsYear
1
Association of maximum voluntary dietary intake of freeze-dried garlic with Heinz body anemia in horses. (15822591)
2005
2
Heinz body anemia in a dog that had been sprayed with skunk musk. (15882003)
2005
3
Heinz body anemia in a dog following possible naphthalene ingestion. (12664426)
1995
4
A review of Heinz-body anemia in the dog induced by toxins. (8470361)
1993
5
Acute Heinz-body anemia due to severe cresol poisoning: successful treatment with erythrocytapheresis. (6722696)
1984
6
Heinz-body anemia: "bite cell" variant--a light and electron microscopic study. (6613984)
1983
7
Heinz body anemia and methemoglobinemia in ponies given red maple (acer rubrum L.) leaves. (7147611)
1982
8
Salicylazosulphapyridine-induced Heinz body anemia. (25555)
1978
9
Effect of hydrocortisone on phenylhydrazine-induced Heinz-body anemia. (688095)
1978
10
Pathological study on experimental Heinz body anemia: intracellular changes of phagocytized red cells in macrophages of the spleen and liver. (930587)
1977
11
Introduction to discussion of Heinz body anemias--unstable hemoglobinopathies. (4941678)
1971
12
Current concepts: Heinz-body anemias. (5782720)
1969
13
HEINZ BODY ANEMIA--AN ULTRASTRUCTURAL STUDY. I. HEINZ BODY FORMATION. (14294766)
1965
14
Heinz body anemia: an ultrastructural study. II. Red cell sequestration and destruction. (5825007)
1965
15
Oxidative hemolysis and precipitation of hemoglobin. I. Heinz body anemias as an acceleration of red cell aging. (13789379)
1960
16
Heinz body anemia and related phenomena. (13642237)
1959

Genetic Variations for Heinz Body Anemia

Expression for genes affiliated with Heinz Body Anemia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Heinz Body Anemia

Search GEO for disease gene expression data for Heinz Body Anemia.

Pathways for genes affiliated with Heinz Body Anemia

Sources:
54Reactome, 38NCBI BioSystems Database, 30KEGG
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Compounds for genes affiliated with Heinz Body Anemia

Sources:
45Novoseek, 11DrugBank, 50PharmGKB, 29IUPHAR, 24HMDB
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Compounds related to Heinz Body Anemia according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
123-diphosphoglycerate459.5HBA2, HBB
2hmba459.4HBB, HBA2
31,3,5-BENZENETRICARBOXYLIC ACID119.3HBB, HBA1
4hydroxyurea45 50 1111.3HBB, HBA2
5valine459.3HBB, HBA2
64-Carboxycinnamic Acid119.3HBA1, HBB
72-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID119.3HBA1, HBB
82-[(2-methoxy-5-methylphenoxy)methyl]pyridine119.3HBA1, HBB
92,6-DICARBOXYNAPHTHALENE119.3HBA1, HBB
104-[(5-methoxy-2-methylphenoxy)methyl]pyridine119.3HBA1, HBB
11SEBACIC ACID119.3HBB, HBA1
122-{4-[(3,5-DIMETHYLANILINO)-CARBONYL-METHYL]-PHENOXY}-2-METHYLPROPIONIC ACID119.2HBB, HBA1
13iron dextran45 1110.2HBB, HBA1
14heme29 11 2410.7HBA1, HBB
15iron45 249.6HBA1, HBB, HBA2
16oxygen45 249.4HBA2, HBB, HBA1

GO Terms for genes affiliated with Heinz Body Anemia

Sources:
16Gene Ontology
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Cellular components related to Heinz Body Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle lumenGO:0716829.3HBB, HBA2
2haptoglobin-hemoglobin complexGO:0318389.2HBB, HBA2
3hemoglobin complexGO:0058339.0HBB, HBA2

Biological processes related to Heinz Body Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxygen transportGO:0156719.4HBB, HBA2
2positive regulation of cell deathGO:0109429.4HBB, HBA2
3hydrogen peroxide catabolic processGO:0427449.3HBA2, HBB
4protein heterooligomerizationGO:0512919.3HBB, HBA2
5bicarbonate transportGO:0157019.2HBB, HBA2
6response to hydrogen peroxideGO:0425429.0HBA2, HBB

Molecular functions related to Heinz Body Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1haptoglobin bindingGO:0317209.4HBB, HBA2
2oxygen transporter activityGO:0053449.4HBB, HBA2
3peroxidase activityGO:0046019.3HBB, HBA2
4iron ion bindingGO:0055069.3HBB, HBA2
5oxygen bindingGO:0198259.2HBA2, HBB
6heme bindingGO:0200379.0HBB, HBA2

Products for genes affiliated with Heinz Body Anemia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Heinz Body Anemia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet