MCID: HNZ001
MIFTS: 30

Heinz Body Anemia malady

Summaries for Heinz Body Anemia

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48OMIM, 34MalaCards
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MalaCards: Heinz Body Anemia, also known as heinz body anemias, is related to hemoglobinopathy and heinz body anemias. An important gene associated with Heinz Body Anemia is HBA2 (hemoglobin, alpha 2), and among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and African trypanosomiasis. The compounds iron dextran and 23-diphosphoglycerate have been mentioned in the context of this disorder. Affiliated tissues include spleen and liver.

Description from OMIM:48 140700

Aliases & Classifications for Heinz Body Anemia

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48OMIM, 63UMLS
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Aliases & Descriptions:

heinz body anemia 48
heinz body anemias 63


Related Diseases for Heinz Body Anemia

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18GeneCards, 19GeneDecks
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Graphical network of the top 20 diseases related to Heinz Body Anemia:



Diseases related to heinz body anemia

Symptoms for Heinz Body Anemia

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48OMIM
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Clinical features from OMIM:

140700

Drugs & Therapeutics for Heinz Body Anemia

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Heinz Body Anemia

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Anatomical Context for Heinz Body Anemia

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34MalaCards
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MalaCards organs/tissues related to Heinz Body Anemia:

34
Spleen, Liver

Animal Models for Heinz Body Anemia or affiliated genes

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Publications for Heinz Body Anemia

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53PubMed
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Articles related to Heinz Body Anemia:

(show all 16)
idTitleAuthorsYear
1
Association of maximum voluntary dietary intake of freeze-dried garlic with Heinz body anemia in horses. (15822591)
2005
2
Heinz body anemia in a dog that had been sprayed with skunk musk. (15882003)
2005
3
Heinz body anemia in a dog following possible naphthalene ingestion. (12664426)
1995
4
A review of Heinz-body anemia in the dog induced by toxins. (8470361)
1993
5
Acute Heinz-body anemia due to severe cresol poisoning: successful treatment with erythrocytapheresis. (6722696)
1984
6
Heinz-body anemia: "bite cell" variant--a light and electron microscopic study. (6613984)
1983
7
Heinz body anemia and methemoglobinemia in ponies given red maple (acer rubrum L.) leaves. (7147611)
1982
8
Salicylazosulphapyridine-induced Heinz body anemia. (25555)
1978
9
Effect of hydrocortisone on phenylhydrazine-induced Heinz-body anemia. (688095)
1978
10
Pathological study on experimental Heinz body anemia: intracellular changes of phagocytized red cells in macrophages of the spleen and liver. (930587)
1977
11
Introduction to discussion of Heinz body anemias--unstable hemoglobinopathies. (4941678)
1971
12
Current concepts: Heinz-body anemias. (5782720)
1969
13
HEINZ BODY ANEMIA--AN ULTRASTRUCTURAL STUDY. I. HEINZ BODY FORMATION. (14294766)
1965
14
Heinz body anemia: an ultrastructural study. II. Red cell sequestration and destruction. (5825007)
1965
15
Oxidative hemolysis and precipitation of hemoglobin. I. Heinz body anemias as an acceleration of red cell aging. (13789379)
1960
16
Heinz body anemia and related phenomena. (13642237)
1959

Variations for Heinz Body Anemia

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Expression for genes affiliated with Heinz Body Anemia

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Heinz Body Anemia

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Pathways for genes affiliated with Heinz Body Anemia

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Sources:
51PathCards, 56Reactome, 31KEGG, 39NCBI BioSystems Database
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Compounds for genes affiliated with Heinz Body Anemia

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 25HMDB, 52PharmGKB
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Compounds related to Heinz Body Anemia according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1iron dextran46 1210.4HBB, HBA1
223-diphosphoglycerate469.2HBB, HBA2
3hmba469.2HBB, HBA2
4heme30 25 1211.1HBB, HBA1
5hydroxyurea46 52 1211.1HBB, HBA2
6methionine469.0HBB, HBA2
7valine468.9HBA2, HBB
8butyrate468.7HBB, HBA2
9iron46 259.7HBA1, HBA2, HBB
10oxygen46 259.6HBA1, HBA2, HBB

GO Terms for genes affiliated with Heinz Body Anemia

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17Gene Ontology
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Cellular components related to Heinz Body Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1haptoglobin-hemoglobin complexGO:0318389.0HBB, HBA2
2blood microparticleGO:0725629.0HBB, HBA2
3hemoglobin complexGO:0058338.9HBB, HBA2
4endocytic vesicle lumenGO:0716828.7HBB, HBA2

Biological processes related to Heinz Body Anemia according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1oxygen transportGO:0156719.2HBB, HBA2
2hydrogen peroxide catabolic processGO:0427449.1HBB, HBA2
3positive regulation of cell deathGO:0109429.1HBB, HBA2
4bicarbonate transportGO:0157019.0HBA2, HBB
5oxidation-reduction processGO:0551149.0HBB, HBA2
6response to hydrogen peroxideGO:0425428.9HBB, HBA2
7protein heterooligomerizationGO:0512918.7HBB, HBA2

Molecular functions related to Heinz Body Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1haptoglobin bindingGO:0317209.1HBB, HBA2
2oxygen transporter activityGO:0053449.1HBB, HBA2
3peroxidase activityGO:0046019.0HBB, HBA2
4iron ion bindingGO:0055069.0HBB, HBA2
5oxygen bindingGO:0198258.9HBA2, HBB
6heme bindingGO:0200378.7HBB, HBA2

Products for genes affiliated with Heinz Body Anemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Heinz Body Anemia

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet