MCID: HNZ001
MIFTS: 23

Heinz Body Anemia malady

Summaries for Heinz Body Anemia

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46OMIM, 32MalaCards
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MalaCards: Heinz Body Anemia, also known as heinz body anemias, is related to heinz body anemias, beta- and hemoglobinopathy. An important gene associated with Heinz Body Anemia is HBA2 (hemoglobin, alpha 2), and among its related pathways are Binding and Uptake of Ligands by Scavenger Receptors and O2/CO2 exchange in erythrocytes. The compounds 23-diphosphoglycerate and hmba have been mentioned in the context of this disorder.

Description from OMIM:46 140700

Aliases & Classifications for Heinz Body Anemia

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60UMLS, 46OMIM
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Aliases & Descriptions:

heinz body anemia 46
heinz body anemias 60


Related Diseases for Heinz Body Anemia

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Heinz Body Anemia:



Diseases related to heinz body anemia

Clinical Features for Heinz Body Anemia

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46OMIM
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Clinical features from OMIM:

140700

Drugs & Therapeutics for Heinz Body Anemia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Heinz Body Anemia

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Genetic Tests for Heinz Body Anemia

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Anatomical Context for Heinz Body Anemia

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Animal Models for Heinz Body Anemia or affiliated genes

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Publications for Heinz Body Anemia

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Genetic Variations for Heinz Body Anemia

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Expression for genes affiliated with Heinz Body Anemia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Heinz Body Anemia

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Pathways for genes affiliated with Heinz Body Anemia

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Sources:
53Reactome, 37NCBI BioSystems Database, 29KEGG
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Compounds for genes affiliated with Heinz Body Anemia

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB
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Compounds related to Heinz Body Anemia according to GeneCards/GeneDecks:

(show all 16)
idCompoundScoreTop Affiliating Genes
123-diphosphoglycerate449.5HBB, HBA2
2hmba449.4HBB, HBA2
34-Carboxycinnamic Acid119.3HBA1, HBB
4hydroxyurea44 49 1111.3HBA2, HBB
5valine449.3HBB, HBA2
61,3,5-BENZENETRICARBOXYLIC ACID119.3HBB, HBA1
7SEBACIC ACID119.3HBB, HBA1
82-{4-[(3,5-DIMETHYLANILINO)-CARBONYL-METHYL]-PHENOXY}-2-METHYLPROPIONIC ACID119.3HBB, HBA1
94-[(5-methoxy-2-methylphenoxy)methyl]pyridine119.3HBB, HBA1
102,6-DICARBOXYNAPHTHALENE119.3HBB, HBA1
112-[(2-methoxy-5-methylphenoxy)methyl]pyridine119.3HBB, HBA1
122-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID119.2HBB, HBA1
13iron dextran44 1110.2HBB, HBA1
14heme28 11 2410.7HBA1, HBB
15iron44 249.6HBA1, HBB, HBA2
16oxygen44 249.4HBA1, HBB, HBA2

GO Terms for genes affiliated with Heinz Body Anemia

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Sources:
16Gene Ontology
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Cellular components related to Heinz Body Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endocytic vesicle lumenGO:0716829.3HBB, HBA2
2haptoglobin-hemoglobin complexGO:0318389.2HBB, HBA2
3hemoglobin complexGO:0058339.0HBB, HBA2

Biological processes related to Heinz Body Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1oxygen transportGO:0156719.4HBB, HBA2
2positive regulation of cell deathGO:0109429.4HBB, HBA2
3hydrogen peroxide catabolic processGO:0427449.3HBB, HBA2
4protein heterooligomerizationGO:0512919.3HBB, HBA2
5bicarbonate transportGO:0157019.2HBA2, HBB
6response to hydrogen peroxideGO:0425429.0HBB, HBA2

Molecular functions related to Heinz Body Anemia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1haptoglobin bindingGO:0317209.4HBB, HBA2
2oxygen transporter activityGO:0053449.4HBB, HBA2
3peroxidase activityGO:0046019.3HBB, HBA2
4iron ion bindingGO:0055069.3HBB, HBA2
5oxygen bindingGO:0198259.2HBA2, HBB
6heme bindingGO:0200379.0HBB, HBA2

Products for genes affiliated with Heinz Body Anemia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Heinz Body Anemia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet