Hellp Syndrome malady

NIH Rare Diseases: HELLP syndrome is a rare but serious illness in pregnancy. This condition can start quickly, most often in the last 3 months of pregnancy (the third trimester). It can also start soon after the baby is delivered. HELLP stands for Hemolysis, Elevated Liver enzyme levels and a Low Platelet count. These problems are often found in women with this syndrome. These problems, along with the high blood pressure commonly found in association with HELLP syndrome, can lead to problems for both the mother and the baby. Many cases of HELLP syndrome are associated with  preeclampsia or eclampsia. The exact cause of HELLP syndrome remains unknown, making it difficult to determine which women will be affected. Treatment may involve medication and/or delivery of the baby.   ³⁰

MalaCards: Hellp Syndrome, also known as syndrome of haemolysis, elevated liver enzymes and low platelet, is related to acute fatty liver of pregnancy and thrombosis. An important gene associated with Hellp Syndrome is HADHA (hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit), and among its related pathways are Extrinsic Prothrombin Activation Pathway and Naphthalene metabolism. The compounds hirudin and glucose have been mentioned in the context of this disorder. Affiliated tissues include liver, placenta and b cells, and related mouse phenotypes are respiratory system and renal/urinary system.

Wikipedia: HELLP syndrome is a life-threatening obstetric complication usually considered to be a variant or...⁴⁴ more...

Aliases & Descriptions:

hellp syndrome 6 7 30 32 43 syndrome of haemolysis, elevated liver enzymes and low platelet 6

hemolysis, elevated liver enzymes, lowered platelets 30 hellp syndrome (disorder) 6

Diseases related to hellp syndrome by text searches and GeneDecks gene sharing:

(show top 50)    (show all 728)

id	Related Disease	Score	Top Affiliating Genes
1	acute fatty liver of pregnancy	29.4	SERPINC1, F3, F2, HADHA
2	thrombosis	29.2	MTHFR, F8, F5, F2
3	atypical hemolytic-uremic syndrome	29.2	CD46, THBD, ADAMTS13
4	hepatitis	28.8	GPT, F2, TAT, SLC17A5
5	placental insufficiency	27.9	VWF, LEP, FLT1, IL6, CST3
6	glucose intolerance	27.6	SERPINE1, LEP, GPT, CRP
7	thrombophilia	27.1	VWF, SERPINC1, SERPINE1, MTHFR, GSTP1, APOH
8	hemolytic-uremic syndrome	25.8	VWF, SERPINC1, SERPINE1, CD46, IL6, APOH
9	chorioamnionitis	25.6	SERPINC1, CGB5, FLT1, IL6, MBL2, ICAM1
10	thrombocytopenia	24.5	VWF, SERPINC1, SERPINE1, BCHE, MTHFR, CD46
11	twinning	22.2	VWF, SERPINC1, SERPINE1, VEGFA, LGALS13, LEP
12	eclampsia	21.4	VWF, SERPINC1, SERPINE1, VEGFA, PAPPA2, LGALS13
13	pre-eclampsia	21.4	VWF, SERPINC1, SERPINE1, VEGFA, PAPPA2, LGALS13
14	homocysteine	20.9	VWF, SERPINC1, SERPINE1, VEGFA, BCHE, LEP
15	glomerulonephritis	20.5	VWF, SERPINC1, SERPINE1, VEGFA, MTHFR, S100A8
16	hypertension	18.6	VWF, SERPINC1, SERPINE1, VEGFA, LEP, MTHFR
17	myocardial infarction	17.4	VWF, SERPINC1, SERPINE1, VEGFA, LEP, MTHFR
18	placental infarction	13.9	SERPINC1, APOH, F5
19	placental abruption	13.9	SERPINC1, MTHFR, F5
20	neonatal stroke	13.8	SERPINE1, MTHFR, F5
21	amaurosis fugax	13.8	SERPINE1, MTHFR, APOH, F5
22	hepatic vein thrombosis	13.8	SERPINE1, MTHFR, F5
23	sagittal sinus thrombosis	13.8	SERPINC1, F5, F3
24	blood protein disease	13.8	MTHFR, F5, F2
25	neonatal intrahepatic cholestasis caused by citrin deficiency	13.8	GPT, F2, SLC17A5
26	non-a-e hepatitis	13.8	GPT, F2, SLC17A5
27	prothrombin deficiency	13.8	SERPINC1, APOH, F5, F2
28	porencephaly	13.8	MTHFR, F5, F2
29	necrotizing fasciitis	13.7	CD46, GPT, F5
30	vein disease	13.7	SERPINC1, MTHFR, F5, F2
31	citrin deficiency	13.7	GPT, F2, SLC17A5
32	meningococcemia	13.7	SERPINC1, SERPINE1, F5, THBD
33	mondor disease	13.7	APOH, F5
34	carotid artery thrombosis	13.7	SERPINC1, SERPINE1, F3
35	legg-calve-perthes disease	13.7	SERPINC1, SERPINE1, F5, THBD
36	acute liver failure	13.7	GPT, F2, OTC, SLC17A5
37	spinal cord infarction	13.7	SERPINC1, MTHFR, APOH, F5, F2
38	antithrombin iii deficiency	13.7	SERPINC1, MTHFR, APOH, F5, F2
39	homocysteine plasma level	13.7	SERPINC1, MTHFR, F5, EDN1
40	protein s deficiency	13.7	SERPINC1, MBL2, F5, HADHA
41	type 1 von willebrand disease	13.7	VWF, MTHFR, F8, ADAMTS13
42	hemolytic anemia	13.6	VWF, APOH, F3, HP, ADAMTS13
43	factor xii deficiency	13.6	F5, F3, F2
44	factor x deficiency	13.6	F5, F3, F2
45	autoimmune hemolytic anemia	13.6	VWF, APOH, F5, F3, HP
46	low renin hypertension	13.6	HSD11B2, CYP11B2, EDN1
47	antiphospholipid syndrome	13.6	APOH, F2
48	afibrinogenemia	13.6	VWF, F3, F2
49	renal hypertension	13.6	GPR182, EDN1, ADM
50	collagen disease	13.6	VWF, APOH, MBL2, THBD

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to hellp syndrome:

²²

MGI Mouse Phenotypes related to hellp syndrome:

²⁵ (show all 20)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.4	WWTR1
2	renal/urinary system phenotype	MP:0005367	9.9	GAPDH, HADHA, HADH, ADM, WWTR1, CYP11B2
3	embryogenesis phenotype	MP:0005380	9.8	HADHA, TGFB3, F2, SERPINC1
4	hematopoietic system phenotype	MP:0005397	9.7	BNIP3, BNIP3L, PAPPA2, INHA, ENG, OTC
5	integument phenotype	MP:0010771	9.2	TLR4, AHSP, NR3C1, OTC, CALCRL, F2
6	liver/biliary system phenotype	MP:0005370	8.7	HADHA, ADM, TLR4, OTC, IL6, PAPPA2
7	tumorigenesis	MP:0002006	7.6	CST3, TLR4, PLAU, HP, F3, ICAM1
8	nervous system phenotype	MP:0003631	7.4	PLAU, EDN1, TSHR, TLR4, THBD, TGFB3
9	reproductive system phenotype	MP:0005389	7.3	F8, OTC, WWTR1, TSHR, TLR4, IL6
10	digestive/alimentary phenotype	MP:0005381	7.2	PLAT, PLAU, NOD2, WWTR1, EDN1, TGFB3
11	behavior/neurological phenotype	MP:0005386	6.9	NR3C1, PLAT, WWTR1, TSHR, TLR4, TGFB3
12	immune system phenotype	MP:0005387	6.9	NR3C1, PLAT, NOD2, WWTR1, AHSP, TSHR
13	skeleton phenotype	MP:0005390	6.8	TGFB3, NOD2, PLAU, PLAT, NR3C1, MAPK14
14	vision/eye phenotype	MP:0005391	6.8	PLAT, PLAU, TLR4, TGFB3, SLC17A5, F3
15	growth/size phenotype	MP:0005378	6.3	OTC, NR3C1, PLAT, PLAU, WWTR1, TSHR
16	muscle phenotype	MP:0005369	5.6	CALCRL, CYP11B2, PLAT, PLAU, EDN1, TLR4
17	cellular phenotype	MP:0005384	4.0	NOD2, PLAU, PLAT, NR3C1, CYP11B2, OTC
18	mortality/aging	MP:0010768	3.6	WWTR1, EDN1, AHSP, TSHR, TLR4, THBD
19	cardiovascular system phenotype	MP:0005385	3.2	FLT1, INHA, IL6, ENG, MAPK14, F5
20	homeostasis/metabolism phenotype	MP:0005376	1.1	VWF, ICAM1, F3, F2, HSD11B2, CALCRL

Articles related to hellp syndrome:

(show top 50)    (show all 77)

id	Title	Authors	Year	Affiliating Genes
1	Placental protein 13 (PP13/galectin-13) undergoes lip id raft-associated subcellular redistribution in the syncytiotrophoblast in pre term preeclampsia and HELLP syndrome. (21596368)	Balogh A.... Than N.G.	2011	LGALS13
2	Use of recombinant human soluble thrombomodulin in th e management of HELLP syndrome complicated by DIC. (20627281)	Ikezoe T.... Yokoyama A.	2010	THBD
3	The role of p38alpha mitogen-activated protein kinase gene in the HELLP syndrome. (19565356)	Corradetti A.... Tranquilli A.L.	2010	MAPK14
4	Soluble endoglin in preeclamptic patients with or wit hout HELLP syndrome. (20430360)	Hertig A.... Rozenberg P.	2010	ENG
5	Leptin gene (TTTC)(n) microsatellite polymorphism in pre-eclampsia and HELLP syndrome. (19634986)	Nagy B.... Rigo J.	2009	LEP
6	HELLP syndrome is associated with an increased inflammatory response, which may be inhibited by administration of prednisolone. (18696354)	van Runnard Heimel P.J.... Bruinse H.W.	2008	IL6, HP, SLC17A5
7	Placental protein 13 (galectin-13) has decreased placental expression but increased shedding and maternal serum concentrations in patients presenting with preterm pre-eclampsia and HELLP syndrome. (18791734)	Than N.G.... Papp Z.	2008	LGALS13
8	Placental overexpression of transforming growth factor-beta3 in the HELLP syndrome. (17671384)	Emanuelli M.... Tranquilli A.L.	2008	TGFB3
9	Hyperreactio luteinalis could be a risk factor for development of HELLP syndrome: case report. (18829007)	Grgic O.... Barisic D.	2008	CGB5
10	Seven placental transcripts characterize HELLP-syndrome. (18374411)	Buimer M.... Ris-Stalpers C.	2008	FLT1, GSTP1, LEP
11	Vascular endothelial growth factor (VEGF) polymorphisms in HELLP syndrome patients determined by quantitative real-time PCR and melting curve analyses. (18167313)	Nagy B.... Rigo J.	2008	VEGFA
12	Neither maternal nor fetal mutation (E474Q) in the alpha-subunit of the trifunctional protein is frequent in pregnancies complicated by HELLP syndrome. (17313315)	Mutze S.... Zerres K.	2007	HADHA
13	High frequency of methylenetetrahydrofolate reductase 677TT genotype in Hungarian HELLP syndrome patients determined by quantitative real-time PCR. (17136107)	Nagy B.... Papp Z.	2007	MTHFR
14	Reduced pseudocholinesterase activity in patients with HELLP syndrome. (17636231)	Lurie S.... Bar J.	2007	BCHE
15	The 4G/5G polymorphism in the plasminogen activator inhibitor-1 gene is not associated with HELLP syndrome. (18058192)	Muetze S.... Rath W.	2007	SERPINE1
16	Lack of association between the CYP11B2 gene polymorphism and preeclampsia, eclampsia, and the HELLP syndrome in Turkish women. (16303227)	Percin F.E.... Cetin A.	2006	CYP11B2
17	No association of polymorphisms in the glutathione S-transferase genes with pre-eclampsia, eclampsia and HELLP syndrome in a Turkish population. (15916660)	Cetin M.... Cetin A.	2005	GSTT1, GSTM1
18	The transplacental passage of prednisolone in pregnancies complicated by early-onset HELLP syndrome. (16226134)	van Runnard Heimel P.J.... Bruinse H.W.	2005	HSD11B2
19	Placental localization and expression of the cell death factors BNip3 and Nix in preeclampsia, intrauterine growth retardation and HELLP syndrome. (16219518)	Stepan H.... Horn L.C.	2005	BNIP3L, BNIP3
20	Factor VIII levels and the risk of pre-eclampsia, HELLP syndrome, pregnancy related hypertension and severe intrauterine growth retardation. (15733972)	Witsenburg C.P.... Scherjon S.A.	2005	F8
21	Lack of correlation between fatty acid oxidation diso rders and haemolysis, elevated liver enzymes, low platelets (HELLP) syndrome? (15858960)	Holub M.... StAPckler-Ipsiroglu S.	2005	HADHA
22	Pseudocholinesterase deficiency associated with HELLP syndrome. (15311366)	Lurie S.... Ezri T.	2004	BCHE
23	Maternal benefit of high-dose intravenous corticosteroid therapy for HELLP syndrome. (14526324)	Martin J.N.... May W.L.	2003	GPT
24	Haptoglobin and its association with the HELLP syndrome. (12624142)	Raijmakers M.T.... Peters W.H.	2003	HP
25	The evaluation of maternal parameters at diagnosis may predict HELLP syndrome severity. (12820835)	Carpani G.... Pardi G.	2003	SLC17A5
26	Antiphospholipid antibodies in HELLP syndrome: clini cal and biological study in 68 women (12657437)	Queyrel V.... Puech F.	2003	APOH
27	Adrenomedullin, calcitonin gene-related peptide and their receptors: evidence for a decreased placental mRNA content in preeclampsia and HELLP syndrome. (11905404)	Knerr I.... Rascher W.	2002	ADM, CALCRL, GPR182
28	Factor V Leiden and factor II G20210A in preeclampsia and HELLP syndrome. (12519104)	Benedetto C.... Massobrio M.	2002	F2, F5
29	Syncytin, a novel human endogenous retroviral gene in human placenta: evidence for its dysregulation in preeclampsia and HELLP syndrome. (11854637)	Knerr I.... Rascher W.	2002	GAPDH, ERVW-1
30	Hemolytic uremic syndrome in twin pregnancy at 32 weeks gestation with HELLP syndrome. Case report (11431643)	Pitton M.A.... Forcellini F.	2001	HP
31	HELLP syndrome and factor V Leiden. (11267721)	Bozzo M.... Pardi G.	2001	SERPINC1, F5, APOH
32	Incidence of the factor V Leiden-mutation, coagulation inhibitor deficiency, and elevated antiphospholipid-antibodies in patients with preeclampsia or HELLP-syndrome. Hemolysis, elevated liver-enzymes, low platelets. (11187029)	von Tempelhoff G.F.... Hommel G.	2000	F5
33	Heterozygosity for the common LCHAD mutation (1528g>C) is not a major cause of HELLP syndrome and the prevalence of the mutation in the Dutch population is low. (10926288)	den Boer M.E.... Wanders R.J.	2000	HADHA
34	Methylenetetrahydrofolate reductase polymorphisms in preeclampsia and the HELLP syndrome. (11118403)	Zusterzeel P.L.... Steegers E.A.	2000	MTHFR
35	Association of HELLP syndrome with autoimmune antibodies and glucose intolerance. (10840997)	Weitgasser R.... Sandhofer F.	2000	TPO, TSHR
36	Intercellular adhesion molecular 1, a diagnostic serum marker in chorioamnionitis, pre-eclampsia and HELLP syndrome (11008336)	Steinborn A.... Kaufmann M.	2000	ICAM1, CRP
37	Association of a decrease in antithrombin III activity with a perinatal elevation in aspartate aminotransferase in women with twin pregnancies: relevance to the HELLP syndrome. (10207801)	Minakami H.... Sato I.	1999	SERPINC1
38	Caesarean section in a patient with a history of HELLP syndrome (10481422)	Higa T.... Okuda Y.	1999	SERPINC1, SLC17A5
39	Relation between gestational thrombocytopenia and the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP syndrome). (9692341)	Minakami H.... Sato I.	1998	SLC17A5
40	HELLP! A cry for laboratory assistance: a comprehensive review of the HELLP syndrome highlighting the role of the laboratory. (9844823)	Jones S.L.	1998	F2, EDN1
41	Lactate dehydrogenase isoenzymes in patients with HELLP syndrome (8963883)	Hamm W.... Switkowski R.	1996	HP
42	HELLP syndrome associated with factor V R506Q mutation. (8616100)	Brenner B.... Thaler I.	1996	F5
43	Coagulation and plasma fibronectin parameters in HELLP syndrome. (8543109)	Paternoster D.M.... Plebani M.	1995	F2, SERPINC1, F3
44	Measuring the concentration of various plasma and placenta extract proteolytic and vascular factors in pregnant patients with HELLP syndrome, pre-/eclampsia and highly pathologic Doppler flow values (8672911)	Kolben M.... Tschesche H.	1995	PLAU, PLAT, SERPINE1
45	HELLP syndrome (8023604)	Rath W.... Kuhn W.	1994	HP
46	Intensive care of a postpartum patient complicated with HELLP syndrome (8320814)	Kubota T.... Matsuki A.	1993	HP
47	Diagnostic problems in HELLP syndrome--presented with reference to 20 case reports (8273433)	Salfelder A.... Blees M.	1993	HP
48	The Hellp syndrome. Clinical and laboratory test results (1631474)	Kuhn W.... Graeff H.	1992	HP
49	Diagnostic and therapeutic problems in HELLP syndrom e (1299079)	Rath W.... Kuhn W.	1992	SERPINC1
50	Haptoglobin as a sensitive marker of hemolysis in HELLP-syndrome. (1358701)	Wilke G.... Kuhn W.	1992	HP

Genes related to hellp syndrome according to GeneCards:

(show top 50)    (show all 60)

id	Symbol	Description	Score	GeneCards Section Context
1	HADHA	hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit	11.0	Publications
2	HP	haptoglobin	11.0	Publications
3	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	11.0	Publications
4	ADAMTS13	ADAM metallopeptidase with thrombospondin type 1 motif, 13	11.0	Publications
5	BCHE	butyrylcholinesterase	11.0	Publications
6	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
7	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
8	SLC17A5	solute carrier family 17 (anion/sugar transporter), member 5	11.0	Publications
9	EPHX2	epoxide hydrolase 2, cytoplasmic	11.0
10	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
11	OTC	ornithine carbamoyltransferase	11.0
12	GSTP1	glutathione S-transferase pi 1	11.0	Publications
13	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications
14	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
15	VWF	von Willebrand factor	11.0	Publications
16	LGALS13	lectin, galactoside-binding, soluble, 13	11.0	Publications
17	GPR182	G protein-coupled receptor 182	11.0	Publications
18	AHSP	alpha hemoglobin stabilizing protein	11.0	Publications
19	BNIP3L	BCL2/adenovirus E1B 19kDa interacting protein 3-like	11.0	Publications
20	CTNNAL1	catenin (cadherin-associated protein), alpha-like 1	11.0	Publications
21	BNIP3	BCL2/adenovirus E1B 19kDa interacting protein 3	11.0	Publications
22	HSD11B2	hydroxysteroid (11-beta) dehydrogenase 2	11.0	Publications
23	INHA	inhibin, alpha	11.0	Publications
24	TGFB3	transforming growth factor, beta 3	11.0	Publications
25	HADH	hydroxyacyl-CoA dehydrogenase	11.0
26	CALCRL	calcitonin receptor-like	11.0	Publications
27	ERVW-1	endogenous retrovirus group W, member 1	11.0	Publications
28	ADM	adrenomedullin	11.0	Publications
29	CYP11B2	cytochrome P450, family 11, subfamily B, polypeptide 2	11.0	Publications
30	ENG	endoglin	11.0	Publications
31	TAT	tyrosine aminotransferase	11.0	Publications
32	CD46	CD46 molecule, complement regulatory protein	11.0	Publications
33	WWTR1	WW domain containing transcription regulator 1	11.0	Publications
34	S100A8	S100 calcium binding protein A8	11.0	Publications
35	CST3	cystatin C	11.0	Publications
36	CGB5	chorionic gonadotropin, beta polypeptide 5	11.0	Publications
37	NOD2	nucleotide-binding oligomerization domain containing 2	11.0	Publications
38	THBD	thrombomodulin	11.0	Publications
39	GAPDH	glyceraldehyde-3-phosphate dehydrogenase	11.0	Publications
40	PAPPA2	pappalysin 2	11.0	Publications
41	TSHR	thyroid stimulating hormone receptor	11.0	Publications
42	TPO	thyroid peroxidase	11.0	Publications
43	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
44	F2	coagulation factor II (thrombin)	11.0	Publications
45	MBL2	mannose-binding lectin (protein C) 2, soluble	11.0	Publications
46	TLR4	toll-like receptor 4	11.0	Publications
47	PLAT	plasminogen activator, tissue	11.0	Publications
48	GSTT1	glutathione S-transferase theta 1	11.0	Publications
49	FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	11.0	Publications
50	LEP	leptin	11.0	Publications

Pathways related to hellp syndrome according to GeneDecks:

(show all 16)

id	Pathway	Score	Top Affiliating Genes
1	Extrinsic Prothrombin Activation Pathway36	10.1	THBD, F2, F3, F5, SERPINC1
2	Naphthalene metabolism41	9.9	EPHX2, GSTT1, GSTP1, GSTM1
3	Naphthalene metabolism10	9.9	EPHX2, GSTT1, GSTP1, GSTM1
4	Platinum Pathway, Pharmacokinetics/Pharmacodynamics34	9.8	GSTM1, GSTP1, GSTT1
5	Intrinsic Prothrombin Activation Pathway36	9.7	THBD, F2, F5, F8, SERPINC1
6	Development Leptin signaling via JAK/STAT and MAPK cascades10	9.7	LEP, CRP
7	Blood Coagulation Cascade36	9.7	THBD, F2, F3, F5, F8, SERPINC1
8	Malaria20	9.3	IL6, ICAM1, TLR4, TGFB3
9	Immune response IL-1 signaling pathway10	9.1	EDN1, F3, MAPK14, IL6, SERPINE1
10	Immune response_IL-1 signaling pathway41	9.1	EDN1, F3, MAPK14, IL6, SERPINE1
11	Chagas disease (American trypanosomiasis)20	9.0	TGFB3, TLR4, MAPK14, IL6, SERPINE1
12	Blood Coagulation Signaling Pathways37	8.9	THBD, VWF, SERPINC1, SERPINE1, F8, F5
13	Complement and coagulation cascades20	8.6	THBD, PLAU, VWF, SERPINC1, SERPINE1, CD46
14	Rheumatoid arthritis20	8.5	TGFB3, TLR4, ICAM1, IL6, FLT1, VEGFA
15	Cell adhesion_Plasmin signaling41	8.4	PLAU, PLAT, MAPK14, VEGFA
16	Cell adhesion Plasmin signaling10	8.2	PLAU, PLAT, MAPK14, VEGFA

Compounds related to hellp syndrome according to GeneDecks:

(show top 50)    (show all 378)

id	Compound	Score	Top Affiliating Genes
1	hirudin32	10.2	THBD, PLAU, F5, SERPINC1
2	glucose32	10.1	GAPDH, HADHA, HADH, TAT, OTC, BNIP3
3	cyclophosphamide32 34 9 9	13.0	F8, MBL2, APOH
4	polyethylene glycol32	9.7	SERPINC1, BCHE, GAPDH, CST3, THBD, TSHR
5	tranexamic acid32 9 9	11.7	PLAU, PLAT, F8, SERPINE1, SERPINC1, VWF
6	aprotinin32 9 9	11.6	THBD, PLAU, PLAT, F2, F5, SERPINC1
7	n acetylcysteine32	9.6	VWF, SERPINC1, SLC17A5, CST3, TLR4, PLAU
8	ascorbic acid32 18	10.4	GAPDH, EPHX2, SLC17A5, TPO, ENG, GSTT1
9	warfarin32 34 9 18 9	13.3	F3, F5, F8, GPT, APOH, MTHFR
10	testosterone32 9 18 9	12.3	EPHX2, TAT, TGFB3, CYP11B2, TPO, F5
11	pge132	9.3	ADM, SLC17A5, THBD, PLAU, PLAT, F5
12	kininogen32	9.1	VWF, SERPINC1, CST3, THBD, PLAU, PLAT
13	desmopressin32 42 9 9	12.0	SERPINC1, VWF, ADAMTS13, THBD, PLAU, PLAT
14	heparin32 9 18 9	11.7	GAPDH, ADAMTS13, TAT, AHSP, PLAU, HP
15	folate32	8.6	CRP, HP, F5, APOH, GSTT1, GSTP1
16	glutamate32	8.5	GAPDH, EPHX2, HADHA, HADH, BCHE, TAT
17	epinephrine32 9 18 9	11.4	SLC17A5, PLAU, HP, F2, F3, F5
18	homocysteine32 18	9.4	SERPINC1, VWF, SERPINE1, APOH, ADM, CST3
19	endotoxin32	8.4	ADM, ADAMTS13, SLC17A5, THBD, AHSP, CRP
20	agarose32	8.3	GAPDH, CST3, THBD, TLR4, TSHR, TPO
21	progesterone32 42 9 18 9	12.3	F8, ENG, INHA, FLT1, CD46, CGB5
22	cysteine32	8.2	GAPDH, MTHFR, S100A8, GSTM1, EPHX2, ADM
23	aspartate32	8.1	GAPDH, EPHX2, SLC17A5, CST3, TAT, THBD
24	p00232	8.0	FLT1, MTHFR, LEP, GSTM1, GSTT1, ADM
25	adenylate32	7.9	HSD11B2, GPR182, GPT, MAPK14, GSTP1, CGB5
26	polysaccharide32	7.9	CD46, CGB5, SERPINC1, MBL2, F8, CST3
27	methotrexate32 34 42 9 9	11.8	APOH, IL6, GSTP1, GSTM1, CGB5, S100A8
28	steroid32	7.7	ADM, ADAMTS13, CST3, TGFB3, THBD, PLAU
29	aspirin32 34 18	9.6	HADHA, THBD, TLR4, AHSP, PLAU, PLAT
30	estrogen32	7.5	HSD11B2, VWF, SERPINC1, F2, F8, ENG
31	prednisolone32 9 9	9.2	GAPDH, SLC17A5, TAT, THBD, TSHR, NOD2
32	simvastatin32 34 42 9 18 9	12.2	TLR4, VWF, PLAT, CRP, F2, F3
33	oxygen32 18	8.2	AHSP, S100A8, BCHE, CGB5, FLT1, NOD2
34	paraffin32	7.1	ADM, TGFB3, THBD, TSHR, PLAU, PLAT
35	arginine32	7.0	EPHX2, ADM, CST3, APOH, GSTT1, CGB5
36	atorvastatin32 34 9 18 9	10.9	PLAU, PLAT, CRP, ICAM1, F5, GPT
37	cyclosporin a32 42	7.7	F2, ICAM1, F8, GPT, IL6, CD46
38	prostacyclin32	6.3	VWF, SERPINC1, PLAU, PLAT, CRP, F3
39	cholesterol32 9 18 9	9.2	ADM, SLC17A5, CST3, THBD, TLR4, TSHR
40	fibrinogen32	6.2	SLC17A5, TAT, THBD, TLR4, AHSP, PLAU
41	alanine32	6.1	ADM, F5, F8, GPT, IL6, GSTP1
42	creatinine32	5.9	HADHA, ADM, ADAMTS13, THBD, EDN1, PLAU
43	actinomycin d32	5.8	THBD, VEGFA, SERPINE1, CGB5, GSTP1, TLR4
44	lactate32	5.8	GAPDH, HADHA, ADM, SLC17A5, CST3, TAT
45	lipid32	5.6	HADHA, ADM, SLC17A5, CST3, TAT, TGFB3
46	nitric oxide32 9 18 9	8.5	MAPK14, MBL2, APOH, IL6, FLT1, CD46
47	dexamethasone32 42 34 9 9	9.3	CALCRL, HSD11B2, ICAM1, F8, MAPK14, ENG
48	serine32	5.0	MAPK14, VWF, SERPINC1, ENG, MBL2, GSTP1
49	cycloheximide32	4.7	CRP, NR3C1, TPO, F3, ICAM1, MAPK14
50	vegf32	3.0	TAT, TGFB3, THBD, TLR4, TSHR, EDN1

Cellular components related to hellp syndrome according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix	GO:031012	9.4	TGFB3, PLAT, F3, APOH, SERPINE1, VWF
2	platelet alpha granule lumen	GO:031093	8.9	TGFB3, F5, F8, VEGFA, SERPINE1, VWF
3	cell surface	GO:009986	8.0	ADAMTS13, TGFB3, THBD, NOD2, PLAU, PLAT
4	plasma membrane	GO:005886	6.8	CALCRL, ERVW-1, TPO, CTNNAL1, PLAU, NOD2
5	extracellular region	GO:005576	5.5	F2, HP, CRP, PLAT, PLAU, EDN1
6	extracellular space	GO:005615	4.6	SERPINC1, F2, HP, CRP, PLAT, PLAU

Biological processes related to hellp syndrome according to GeneDecks:

(show all 22)

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of blood coagulation	GO:030194	10.3	SERPINE1, APOH, F2
2	negative regulation of fibrinolysis	GO:051918	10.3	SERPINE1, APOH, F2, THBD
3	detection of hypoxia	GO:070483	10.2	ENG, TGFB3
4	chronological cell aging	GO:001300	10.2	SERPINE1, ENG
5	negative regulation of blood coagulation	GO:030195	10.2	THBD, EDN1, APOH, SERPINE1
6	blood coagulation, intrinsic pathway	GO:007597	10.0	F2, F8, APOH, VWF
7	regulation of blood volume by renal aldosterone	GO:002017	10.0	HSD11B2, CYP11B2
8	fibrinolysis	GO:042730	9.8	PLAU, PLAT, F2, SERPINE1
9	cellular response to lipopolysaccharide	GO:071222	9.8	TLR4, ICAM1, GSTP1, SERPINE1
10	female pregnancy	GO:007565	9.7	ADM, TGFB3, THBD, HSD11B2, FLT1, LEP
11	defense response to Gram-negative bacterium	GO:050829	9.7	SERPINE1, IL6, TLR4
12	response to glucocorticoid stimulus	GO:051384	9.5	ADM, TAT, PLAT, HSD11B2, IL6, BCHE
13	response to lipopolysaccharide	GO:032496	9.5	ADM, THBD, TLR4, EDN1, F3, S100A8
14	response to insulin stimulus	GO:032868	9.4	HADH, ADM, TLR4, NR3C1, OTC, HSD11B2
15	positive regulation of smooth muscle cell proliferation	GO:048661	9.4	EDN1, CALCRL, IL6, FLT1
16	platelet degranulation	GO:002576	9.2	TGFB3, F5, F8, VEGFA, SERPINE1, VWF
17	positive regulation of angiogenesis	GO:045766	9.2	ADM, F3, FLT1, VEGFA, SERPINE1
18	acute-phase response	GO:006953	8.9	CRP, F2, F8, MBL2, IL6
19	platelet activation	GO:030168	8.0	ADAMTS13, TGFB3, F2, F5, F8, MAPK14
20	positive regulation of cell proliferation	GO:008284	7.8	ADM, TSHR, EDN1, WWTR1, F2, IL6
21	blood coagulation	GO:007596	7.5	F2, PLAT, PLAU, THBD, TGFB3, F3
22	response to hypoxia	GO:001666	7.4	VEGFA, ADM, TGFB3, TLR4, EDN1, PLAT

Molecular functions related to hellp syndrome according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	adrenomedullin receptor activity	GO:001605	10.3	GPR182, CALCRL
2	protease binding	GO:002020	10.1	CST3, F3, SERPINE1, SERPINC1
3	transmembrane signaling receptor activity	GO:004888	9.5	THBD, TLR4, ICAM1, GPR182, ENG
4	cell surface binding	GO:043498	8.8	VEGFA, ICAM1, F3
5	growth factor activity	GO:008083	8.5	TGFB3, F2, IL6, INHA, LEP, VEGFA
6	protein homodimerization activity	GO:042803	7.9	EPHX2, WWTR1, CRP, NR3C1, ENG, BNIP3L
7	protein binding	GO:005515	3.4	GAPDH, CALCRL, NR3C1, CRP, PLAT, PLAU