MCID: HLL004
MIFTS: 46

Hellp Syndrome malady

Rare diseases, Liver diseases, Blood diseases categories

Aliases & Classifications for Hellp Syndrome

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Hellp Syndrome, Aliases & Descriptions:

Name: Hellp Syndrome 9 41 43 60
Syndrome of Haemolysis, Elevated Liver Enzymes and Low Platelet 9
 
Hemolysis, Elevated Liver Enzymes, Lowered Platelets 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Liver diseases, Blood diseases


External Ids:

Disease Ontology9 DOID:13133
MeSH33 D017359
SNOMED-CT55 199010001, 95605009
NCIt38 C84750
ICD1025 O14.2

Summaries for Hellp Syndrome

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NIH Rare Diseases:41 Hellp syndrome is a rare but serious illness in pregnancy. this condition can start quickly, most often in the last 3 months of pregnancy (the third trimester). it can also start soon after the baby is delivered. hellp stands for hemolysis, elevated liver enzyme levels and a low platelet count. these problems are often found in women with this syndrome. these problems, along with the high blood pressure commonly found in association with hellp syndrome, can lead to problems for both the mother and the baby. many cases of hellp syndrome are associated with  preeclampsia or eclampsia. the exact cause of hellp syndrome remains unknown, making it difficult to determine which women will be affected. treatment may involve medication and/or delivery of the baby.    last updated: 1/26/2010

MalaCards based summary: Hellp Syndrome, also known as syndrome of haemolysis, elevated liver enzymes and low platelet, is related to eclampsia and purpura. An important gene associated with Hellp Syndrome is HADHA (hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit), and among its related pathways are Complement and coagulation cascades and Formation of Fibrin Clot (Clotting Cascade). The compounds inogatran and hirugen have been mentioned in the context of this disorder. Affiliated tissues include liver, placenta and testes, and related mouse phenotypes are liver/biliary system and homeostasis/metabolism.

Wikipedia:63 HELLP syndrome is a life-threatening obstetric complication usually considered to be a variant or... more...

Related Diseases for Hellp Syndrome

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Diseases related to Hellp Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 134)
idRelated DiseaseScoreTop Affiliating Genes
1eclampsia32.0SERPINC1
2purpura30.9ADAMTS13, SERPINC1
3pancreatitis30.6BCHE, SLC17A5
4severe pre-eclampsia30.5SERPINC1, F5, APOH
5antiphospholipid syndrome30.4F5, ADAMTS13, APOH, SERPINC1
6lupus erythematosus30.4APOH, SERPINC1, F5
7placental abruption30.3SERPINC1, F5
8cholestasis30.3HADHA, SLC17A5
9acute kidney failure30.2ADAMTS13, HP
10thrombophilia30.2APOH, SERPINC1, F5
11disseminated intravascular coagulation30.2F5, ADAMTS13, SERPINC1
12hemolytic anemia30.2HP, APOH, ADAMTS13
13central retinal vein occlusion30.2F5, APOH
14cystic fibrosis30.1BCHE, HADHA, HP
15myocardial infarction30.1F5, ADAMTS13, SERPINC1
16proteinuria30.0ADAMTS13, HP, APOH
17coronary artery disease29.9HP, BCHE, ADAMTS13
18lupus nephritis29.9APOH, ADAMTS13
19ischemia29.9ADAMTS13, SLC17A5, HP
20retinal vein occlusion29.9APOH, SERPINC1, F5
21pulmonary embolism29.9F5, SERPINC1, APOH
22thrombocytopenia29.2SLC17A5, BCHE, HP, APOH, F5, ADAMTS13
23preeclampsia/eclampsia 128.6ADAMTS13, SLC17A5, F5, HP, HADHA, APOH
24hepatitis10.8
25pre-eclampsia10.8
26retinitis10.6
27retinal detachment10.5
28coronary thrombosis10.4SERPINC1
29branch retinal artery occlusion10.4F5
30cholangitis10.4SLC17A5
31patent foramen ovale10.4F5
32evans' syndrome10.4ADAMTS13
33systemic lupus erythematosus10.4
34diabetes insipidus10.4
35cerebritis10.4
36blindness10.4
37retinal artery occlusion10.3APOH
38thrombotic thrombocytopenic purpura10.3
39endotheliitis10.3
40thrombophlebitis10.3APOH
41pepck 2 deficiency10.3SERPINC1, HP
42cortical blindness10.3
43splenomegaly10.3SLC17A5, HP
44post-thrombotic syndrome10.2F5, SERPINC1
45legg-calve-perthes disease10.2SERPINC1, F5
46sagittal sinus thrombosis10.2F5, SERPINC1
47thrombotic thrombocytopenic purpura, familial10.2ADAMTS13, HP
48blood protein disease10.2F5, SERPINC1
49portal vein thrombosis10.2SERPINC1, F5
50thrombocytosis10.2HP, SERPINC1

Graphical network of the top 20 diseases related to Hellp Syndrome:



Diseases related to hellp syndrome

Symptoms for Hellp Syndrome

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Drugs & Therapeutics for Hellp Syndrome

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Drug clinical trials:

Search ClinicalTrials for Hellp Syndrome

Search NIH Clinical Center for Hellp Syndrome

Genetic Tests for Hellp Syndrome

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Anatomical Context for Hellp Syndrome

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MalaCards organs/tissues related to Hellp Syndrome:

31
Liver, Placenta, Testes, Endothelial, Brain, Kidney, Bone, Bone marrow, Spinal cord, Lung, Skin, Cervix, Myeloid, Pituitary, Neutrophil

Animal Models for Hellp Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Hellp Syndrome:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8F5, HP, SERPINC1, HADHA
2MP:00053766.3SLC17A5, HADHA, APOH, SERPINC1, ADAMTS13, HP
3MP:00107686.1HADHA, APOH, SERPINC1, ADAMTS13, HP, BCHE

Publications for Hellp Syndrome

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Articles related to Hellp Syndrome:

(show top 50)    (show all 548)
idTitleAuthorsYear
1
Activation of Villous Trophoblastic p38 and ERK1/2 Signaling Pathways in Preterm Preeclampsia and HELLP Syndrome. (25583406)
2015
2
Microcirculation Approach in HELLP Syndrome Complicated by Posterior Reversible Encephalopathy Syndrome and Massive Hepatic Infarction. (25485160)
2014
3
Postpartum HELLP syndrome and subcapsular liver haematoma. (24789156)
2014
4
Plasma From Patients With HELLP Syndrome Increases Blood-Brain Barrier Permeability. (25194151)
2014
5
CMV infection, TLR-2 and -4 expression, and cytokine profiles in early-onset preeclampsia with HELLP syndrome. (24612145)
2014
6
The management of the surgical complications of HELLP syndrome. (25245729)
2014
7
Changes of placental syndecan-1 expression in preeclampsia and HELLP syndrome. (23807541)
2013
8
COHELLP: collaborative randomized controlled trial on corticosteroids in HELLP syndrome. (23697398)
2013
9
HELLP syndrome and its relation with the antiphospholipid syndrome. (24333078)
2013
10
Use of recombinant human soluble thrombomodulin in the management of HELLP syndrome complicated by DIC. (20627281)
2010
11
The HELLP syndrome. (20491358)
2010
12
Leptin receptor (LEPR) SNP polymorphisms in HELLP syndrome patients determined by quantitative real-time PCR and melting curve analysis. (20149225)
2010
13
Gestational diabetes insipidus, HELLP syndrome and eclampsia in a twin pregnancy: a case report. (20118941)
2010
14
Maternal deaths due to eclampsia and HELLP syndrome. (19027902)
2009
15
ABO incompatible liver transplantation as a bridge to treat HELLP syndrome. (19794830)
2009
16
Prevalence rate of acute renal failure in HELLP syndrome: a summary from a single country's data. (19839862)
2009
17
Bilateral serous retinal detachment in a woman with HELLP syndrome HELLP syndrome and retinal detachment. (19358039)
2009
18
Ketonuria and HELLP syndrome. (21686464)
2009
19
The HELLP syndrome, antiphospholipid antibodies, and syndromes. (17912576)
2008
20
Mannose-binding lectin (MBL) codon 54 gene polymorphism protects against development of pre-eclampsia, HELLP syndrome and pre-eclampsia-associated intrauterine growth restriction. (17314117)
2007
21
Dexamethasone, HELLP syndrome, and study design. (16677590)
2006
22
Characteristics and treatment of hepatic rupture caused by HELLP syndrome. (16579935)
2006
23
Argon beam coagulator for treatment of hepatic rupture with hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome. (16449174)
2006
24
Addition of platelet transfusions to corticosteroids does not increase the recovery of severe HELLP syndrome. (16388885)
2006
25
Neonatal outcome after preterm delivery in HELLP syndrome. (16807990)
2006
26
Lack of association between the CYP11B2 gene polymorphism and preeclampsia, eclampsia, and the HELLP syndrome in Turkish women. (16303227)
2006
27
Understanding and managing HELLP syndrome: the integral role of aggressive glucocorticoids for mother and child. (16631593)
2006
28
The transplacental passage of prednisolone in pregnancies complicated by early-onset HELLP syndrome. (16226134)
2005
29
Pseudocholinesterase deficiency associated with HELLP syndrome. (15311366)
2004
30
Case of HELLP syndrome with an unusual presentation. (15242509)
2004
31
Pregnancy complicated by HELLP syndrome]. (15884197)
2004
32
The effect of glyceryl trinitrate on hypertension in women with severe preeclampsia, HELLP syndrome, and eclampsia. (15117599)
2004
33
Dexamethasone compared with betamethasone for glucocorticoid treatment of postpartum HELLP syndrome. (12628531)
2003
34
A case of postpartum cerebellar infarction with hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome. (12186992)
2002
35
The impact of parity on the incidence of HELLP syndrome and small for gestational age infants in hypertensive pregnant women. (12196855)
2002
36
HELLP syndrome and factor V Leiden. (11267721)
2001
37
Doppler sonographic findings for hypertension in pregnancy and HELLP syndrome. (10642960)
1999
38
Altered lipid metabolism in preeclampsia and HELLP syndrome: links to enhanced platelet reactivity and fetal growth. (10625202)
1999
39
HELLP syndrome: recognition and perinatal management. (10498110)
1999
40
A review of HELLP syndrome. (10642976)
1999
41
Relation between gestational thrombocytopenia and the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP syndrome). (9692341)
1998
42
Liver function following pregnancy complicated by the HELLP syndrome. (9853772)
1998
43
Thrombocytopenia in preeclampsia: an earlier detector of HELLP syndrome. (9361486)
1997
44
Ethnic variation in the incidence of HELLP syndrome in a hypertensive pregnant population. (9494922)
1997
45
HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets) pathophysiology and anesthetic considerations. (9223938)
1997
46
Lactate dehydrogenase isoenzymes in patients with HELLP syndrome]. (8963883)
1996
47
Plasma exchange for preeclampsia: III. Immediate peripartal utilization for selected patients with HELLP syndrome. (7706196)
1994
48
An atypical case of hemolysis, elevated liver enzymes and low platelet count (HELLP) syndrome. (7907061)
1994
49
HELLP syndrome: a variant of severe preeclampsia. (8196820)
1994
50
The Hellp syndrome. Clinical and laboratory test results]. (1631474)
1992

Variations for Hellp Syndrome

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Expression for genes affiliated with Hellp Syndrome

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Search GEO for disease gene expression data for Hellp Syndrome.

Pathways for genes affiliated with Hellp Syndrome

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Pathways related to Hellp Syndrome according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Complement Activation, Classical Pathway36
Complement and Coagulation Cascades36
9.5F5, SERPINC1
2
Show member pathways
9.5F5, SERPINC1

Compounds for genes affiliated with Hellp Syndrome

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Compounds related to Hellp Syndrome according to GeneCards Suite gene sharing:

(show top 50)    (show all 127)
idCompoundScoreTop Affiliating Genes
1inogatran439.8SERPINC1, F5
2hirugen439.8SERPINC1, F5
3ecarin439.8SERPINC1, F5
4hepaplastin439.8SLC17A5, SERPINC1
5spectrozyme439.7F5, SERPINC1
6nafamostat mesilate439.6F5, SERPINC1
7danaparoid439.6SERPINC1, F5
8ximelagatran43 1210.5SERPINC1, F5
9levonorgestrel43 59 28 1212.5SLC17A5, F5, SERPINC1
10vitamin-e439.4SLC17A5, HP, F5
11aprotinin43 1210.3F5, SLC17A5, SERPINC1
12ristocetin439.3F5, SERPINC1, ADAMTS13
13desmopressin43 59 28 1212.2ADAMTS13, SERPINC1, F5
14ancrod439.2SERPINC1, F5
15citrate439.2HP, HADHA, SERPINC1, F5
16tween 20439.1BCHE, APOH
17ascorbic acid43 2410.1HP, SLC17A5, F5, SERPINC1
18kaolin439.0APOH, F5
19dextran sulfate439.0F5, SERPINC1, APOH
20warfarin43 49 24 1212.0F5, APOH, SERPINC1
21ticlopidine43 1210.0SERPINC1, ADAMTS13, APOH
22rituximab43 49 1211.0HP, ADAMTS13, APOH
23urea43 24 1211.0ADAMTS13, HP, F5, SLC17A5
24nacl438.9ADAMTS13, F5, HP, SLC17A5
25vitamin b12438.8HP, APOH, F5, SLC17A5
26malondialdehyde438.8F5, SLC17A5, HP, APOH
27uric acid43 249.8HP, SLC17A5, F5, APOH
28kininogen438.7APOH, F5, HP, SERPINC1
29homocysteine43 249.7HP, F5, APOH, SERPINC1
30polyacrylamide438.7HP, SLC17A5, F5, APOH
31prostacyclin438.7SERPINC1, F5, HADHA, APOH
32ethanol43 49 24 1211.7BCHE, SLC17A5, HP, APOH
33phospholipid438.7SLC17A5, F5, APOH, HP
34polyethylene glycol438.6SERPINC1, BCHE, F5, SLC17A5, HP
35pge1438.6APOH, F5, SLC17A5, BCHE
36cocaine43 129.6F5, BCHE, APOH, SLC17A5
37fatty acid438.6BCHE, SLC17A5, APOH, HADHA
38cyclophosphamide43 49 1210.4F5, BCHE, ADAMTS13, APOH
39folate438.3F5, SLC17A5, HP, SERPINC1, APOH
40glucose438.3HP, HADHA, APOH, SLC17A5, BCHE
41alanine438.3F5, SLC17A5, BCHE, SERPINC1, HADHA, HP
42endotoxin438.2SLC17A5, HP, ADAMTS13, APOH, F5
43serine438.0SERPINC1, HP, BCHE, F5, HADHA, ADAMTS13
44lactate437.9HP, HADHA, BCHE, APOH, F5, SLC17A5
45glutamate437.9HADHA, F5, SLC17A5, APOH, BCHE, HP
46aspirin43 49 28 2410.9HP, BCHE, F5, SERPINC1, APOH, HADHA
47fibrinogen437.7SERPINC1, SLC17A5, F5, HP, APOH, ADAMTS13
48calcium43 49 24 1210.4HADHA, APOH, HP, BCHE, ADAMTS13, F5
49heparin43 28 24 1210.2SLC17A5, SERPINC1, APOH, ADAMTS13, HP, BCHE
50creatinine436.9BCHE, HP, ADAMTS13, SERPINC1, F5, HADHA

GO Terms for genes affiliated with Hellp Syndrome

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Cellular components related to Hellp Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:00725628.8SERPINC1, HP, BCHE
2extracellular regionGO:00055768.6F5, BCHE, HP, SERPINC1
3extracellular spaceGO:00056157.1F5, BCHE, HP, ADAMTS13, SERPINC1, APOH

Molecular functions related to Hellp Syndrome according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1catalytic activityGO:00038249.6BCHE, HP

Products for genes affiliated with Hellp Syndrome

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Sources for Hellp Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
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35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
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56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet