MCID: HLL004
MIFTS: 54

Hellp Syndrome malady

Liver, Blood categories

Summaries for Hellp Syndrome

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Hellp syndrome is a rare but serious illness in pregnancy. this condition can start quickly, most often in the last 3 months of pregnancy (the third trimester). it can also start soon after the baby is delivered. hellp stands for hemolysis, elevated liver enzyme levels and a low platelet count. these problems are often found in women with this syndrome. these problems, along with the high blood pressure commonly found in association with hellp syndrome, can lead to problems for both the mother and the baby. many cases of hellp syndrome are associated with  preeclampsia or eclampsia. the exact cause of hellp syndrome remains unknown, making it difficult to determine which women will be affected. treatment may involve medication and/or delivery of the baby.    last updated: 1/26/2010

MalaCards: Hellp Syndrome, also known as syndrome of haemolysis, elevated liver enzymes and low platelet, is related to eclampsia and antiphospholipid syndrome. An important gene associated with Hellp Syndrome is HADHA (hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit), and among its related pathways are Platelet degranulation and Complement and coagulation cascades. The compounds estrogen and warfarin have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spinal cord, and related mouse phenotypes are liver/biliary system and cardiovascular system.

Wikipedia:64 HELLP syndrome is a life-threatening obstetric complication usually considered to be a variant or... more...

Aliases & Classifications for Hellp Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 45Novoseek, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver, Blood


Aliases & Descriptions:

hellp syndrome 8 43 45 61
syndrome of haemolysis, elevated liver enzymes and low platelet 8
hemolysis, elevated liver enzymes, lowered platelets 43


External Ids:

Disease Ontology8 DOID:13133
NCIt40 C84750
SNOMED-CT57 199010001, 95605009
MeSH35 D017359
ICD1025 O14.2

Related Diseases for Hellp Syndrome

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hellp Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 217)
idRelated DiseaseScoreTop Affiliating Genes
1eclampsia31.2MTHFR, SERPINC1
2antiphospholipid syndrome30.9APOH, F5, MTHFR, VWF, SERPINC1, ADAMTS13
3thrombocytopenia30.6APOH, F5, HP, VWF, GPT, SLC17A5
4thrombophilia30.3APOH, F5, MTHFR, VWF, SERPINE1, SERPINC1
5acute pancreatitis30.2SLC17A5, GPT
6hemolytic-uremic syndrome30.2ADAMTS13, VWF
7nephritis30.2APOH
8hepatitis c30.2SLC17A5, GPT, HP
9central retinal vein occlusion30.0APOH, F5, MTHFR
10portal vein thrombosis30.0F5, MTHFR, SERPINC1
11cystic fibrosis30.0BCHE, OTC, HP, HADHA
12placental abruption30.0F5, MTHFR, SERPINC1
13glucose intolerance30.0GPT, SERPINE1
14hepatic vein thrombosis30.0SERPINC1, SERPINE1
15lupus nephritis30.0ADAMTS13, APOH
16acute kidney failure30.0ADAMTS13, GPT, HP
17coronary artery disease,30.0MTHFR, AHSP, HP, VWF, SERPINE1, BCHE
18n syndrome10.8
19micro syndrome10.4
20char syndrome10.4
21systemic lupus erythematosus10.3
22diabetes insipidus10.3
23thrombotic thrombocytopenic purpura10.2
24cortical blindness10.2
25kid syndrome10.2
26blindness10.2
27pulmonary edema10.1
28hepatitis d10.1
29triple-a syndrome10.1
30hepatitis a10.1
31catastrophic antiphospholipid syndrome10.1
32triploidy10.1
33mass syndrome10.1
34hellp syndrome, maternal, of pregnancy10.1
35cardiac tamponade10.0
36gilbert syndrome10.0
37hepatitis e10.0
38acute myeloid leukemia10.0
39west syndrome10.0
40proliferative glomerulonephritis10.0
41mesangial proliferative glomerulonephritis10.0
42chorioamnionitis10.0
43good syndrome10.0
44pituitary apoplexy10.0
45ocular hypertension10.0
46gestational diabetes10.0
47peripartum cardiomyopathy10.0
48placental insufficiency10.0
49acute leukemia10.0
50acute proliferative glomerulonephritis10.0

Graphical network of the top 20 diseases related to Hellp Syndrome:



Diseases related to hellp syndrome

Clinical Features for Hellp Syndrome

Drugs & Therapeutics for Hellp Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Hellp Syndrome

Drug clinical trials:

Search ClinicalTrials for Hellp Syndrome

Search NIH Clinical Center for Hellp Syndrome

Search CenterWatch for Hellp Syndrome

Genetic Tests for Hellp Syndrome

Anatomical Context for Hellp Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Hellp Syndrome:

33
Skin, Liver, Spinal cord, Brain, Kidney, Lung, Uterus, Bone marrow, Placenta, Cervix, Myeloid, T cells, B cells, Endothelial, Fetal brain, Fetal liver, Fetal lung, Pituitary

Animal Models for Hellp Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Hellp Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537010.2SERPINC1, SERPINE1, OTC, HP, F5, HADHA
2MP:000538510.0BNIP3, HADHA, EPHX2, HP
3MP:00053769.8ADAMTS13, BNIP3, APOH, HADHA, F5, MTHFR
4MP:00107689.7AHSP, MTHFR, F5, HADHA, APOH, HP

Publications for Hellp Syndrome

Sources:
51PubMed
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Articles related to Hellp Syndrome:

(show top 50)    (show all 526)
idTitleAuthorsYear
1
miRNA expression profiles determined in maternal sera of patients with HELLP syndrome. (24304191)
2013
2
Spectrum of neurological complications in HELLP syndrome. (24262446)
2013
3
Hellp syndrome and composite major maternal morbidity: importance of Mississippi classification system. (23387811)
2013
4
Third nerve palsy associated with preeclampsia and HELLP syndrome. (23478950)
2013
5
Managing pregnancy with HIV, HELLP syndrome and low platelets. (22104081)
2012
6
HELLP syndrome in pregnancies below 26th week. (21801142)
2012
7
Patient with antiphospholipid syndrome accompanied by pre-eclampsia who developed hellp syndrome and eclampsia after abortion. (23158159)
2012
8
Hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome in a 26-year-old woman with cystic fibrosis: a case report. (22620288)
2012
9
A case of HELLP syndrome with multiple complications. (22892509)
2012
10
Anesthetic management of HELLP syndrome complicating primary antiphospholipid syndrome -A case report-. (22778897)
2012
11
A case of video-assisted retroperitoneal debridement in a patient with HELLP syndrome. (22678339)
2012
12
Low levels of protein Z are associated with HELLP syndrome and its severity. (20460354)
2011
13
Microarray profiling reveals that placental transcriptomes of early-onset HELLP syndrome and preeclampsia are similar. (20541258)
2011
14
Clinical differences between early-onset HELLP syndrome and early-onset preeclampsia during pregnancy and at least 6 months postpartum. (20022586)
2010
15
The role of p38alpha mitogen-activated protein kinase gene in the HELLP syndrome. (19565356)
2010
16
Liver transplantation for spontaneous hepatic rupture associated with HELLP syndrome. (20619409)
2010
17
Maternal deaths due to eclampsia and HELLP syndrome. (19027902)
2009
18
HELLP syndrome: an atypical presentation. (18342825)
2008
19
Dexamethasone, HELLP syndrome, and study design. (16677590)
2006
20
Understanding and managing HELLP syndrome: the integral role of aggressive glucocorticoids for mother and child. (16631593)
2006
21
It has been a great ride: The history of HELLP syndrome. (16150288)
2005
22
HELLP syndrome: a report of two cases. (16350709)
2005
23
The effect of glyceryl trinitrate on hypertension in women with severe preeclampsia, HELLP syndrome, and eclampsia. (15117599)
2004
24
Systemic lupus erythematosus complicated by HELLP syndrome. (15675219)
2004
25
A case report of spontaneous splenic capsular rupture associated with atypical presentation of haemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome. (15203642)
2004
26
HELLP syndrome: the state of the art. (15572962)
2004
27
Alteration of homocysteine catabolism in pre-eclampsia, HELLP syndrome and placental insufficiency. (15552268)
2004
28
HELLP syndrome complicated by visual loss. (12963522)
2003
29
The importance of parity to major maternal morbidity in the eclamptic mother with HELLP syndrome. (14572365)
2003
30
The evaluation of maternal parameters at diagnosis may predict HELLP syndrome severity. (12820835)
2003
31
Correlation of platelet count changes with liver cell destruction in HELLP syndrome. (12648443)
2003
32
Factor V Leiden and factor II G20210A in preeclampsia and HELLP syndrome. (12519104)
2002
33
Syncytin, a novel human endogenous retroviral gene in human placenta: evidence for its dysregulation in preeclampsia and HELLP syndrome. (11854637)
2002
34
Clinical and biophysical aspects of HELLP-syndrome. (12530105)
2002
35
Leukocytosis is proportional to HELLP syndrome severity: evidence for an inflammatory form of preeclampsia. (10963506)
2000
36
Methylenetetrahydrofolate reductase polymorphisms in preeclampsia and the HELLP syndrome. (11118403)
2000
37
Haemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome associated with increased maternal serum levels of soluble HLA-DR antigens. (10985521)
2000
38
Acute pancreatitis and deep vein thrombosis associated with HELLP syndrome. (10230242)
1999
39
Massive liver haemorrhage and rupture caused by HELLP-syndrome treated by collagen fleeces coated with fibrin glue. (9728792)
1998
40
Thrombocytopenia in preeclampsia: an earlier detector of HELLP syndrome. (9361486)
1997
41
Maternal and neonatal outcome of pregnancies complicated with maternal HELLP syndrome. (9280089)
1997
42
Doppler velocimetry of hepatic blood flow in postpartum patients with HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets) (8987963)
1996
43
The role of labetalol and propofol in the management of HELLP syndrome--a case report. (9084519)
1996
44
Treatment of HELLP syndrome with nitric oxide donor. (7815862)
1995
45
Hepatic hemorrhage and the HELLP syndrome: a surgeon's perspective. (7661469)
1995
46
Pregnancies complicated by HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): subsequent pregnancy outcome and long-term prognosis. (7847520)
1995
47
Measuring the concentration of various plasma and placenta extract proteolytic and vascular factors in pregnant patients with HELLP syndrome, pre-/eclampsia and highly pathologic Doppler flow values]. (8672911)
1995
48
Glutathione S-transferase alpha as marker for hepatocellular damage in pre-eclampsia and HELLP syndrome. (7791457)
1995
49
Plasma exchange for preeclampsia: III. Immediate peripartal utilization for selected patients with HELLP syndrome. (7706196)
1994
50
A case of mild ocular manifestations in pregnancy induced hypertension with HELLP syndrome. (7976276)
1994

Genetic Variations for Hellp Syndrome

Expression for genes affiliated with Hellp Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hellp Syndrome

Search GEO for disease gene expression data for Hellp Syndrome.

Pathways for genes affiliated with Hellp Syndrome

Sources:
54Reactome, 30KEGG, 38NCBI BioSystems Database, 53R&D Systems
See all sources

Pathways related to Hellp Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3SERPINE1, VWF, F5
2
Hide members
10.3F5, VWF, SERPINE1, SERPINC1
3
Hide members
10.3SERPINC1, SERPINE1, VWF, F5

Compounds for genes affiliated with Hellp Syndrome

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 2BitterDB, 29IUPHAR, 60Tocris Bioscience
See all sources

Compounds related to Hellp Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 178)
idCompoundScoreTop Affiliating Genes
1estrogen4510.8APOH, AHSP
2warfarin45 50 11 2413.7SERPINC1, VWF, APOH
3aspartate4510.6GPT, SLC17A5, OTC, BCHE, EPHX2
4acetaminophen45 2 50 11 2414.6GPT, EPHX2, SLC17A5
5heparin45 29 11 2413.6APOH, ADAMTS13, MTHFR, AHSP, HP, BCHE
6desmopressin45 60 29 1113.6ADAMTS13, SERPINC1, F5, VWF, SERPINE1
7ristocetin4510.6F5, SERPINC1, ADAMTS13, VWF
8ticlopidine45 1111.6VWF, APOH, SERPINC1, ADAMTS13
9kininogen4510.6SERPINE1, SERPINC1, F5, VWF, HP, APOH
10malondialdehyde4510.6F5, HP, GPT, SLC17A5, APOH
11valproate4510.6SLC17A5, MTHFR, GPT, OTC, EPHX2
12serine4510.6HADHA, EPHX2, HP, ADAMTS13, BCHE
13vitamin b124510.6SLC17A5, VWF, F5, MTHFR, HP, GPT
14urea45 11 2412.6OTC, EPHX2, HP, SLC17A5, GPT, F5
15uric acid45 2411.6APOH, HP, GPT, SLC17A5, SERPINE1, F5
16metformin45 50 1112.6GPT, SLC17A5, MTHFR, SERPINE1, VWF, F5
17glutamate4510.6APOH, HADHA, EPHX2, AHSP, GPT, OTC
18pge14510.5BCHE, F5, APOH, VWF, SERPINE1, SLC17A5
19endotoxin4510.5ADAMTS13, SERPINE1, HP, AHSP, F5, APOH
20folate4510.5GSTP1, APOH, F5, MTHFR, HP, SLC17A5
21simvastatin45 50 60 29 11 2415.5BCHE, VWF, GPT, SLC17A5, F5, SERPINE1
22aprotinin45 1111.5VWF, SLC17A5, SERPINC1, F5, SERPINE1
23prostacyclin4510.5HADHA, F5, SERPINE1, APOH, SERPINC1, VWF
24homocysteine45 2411.5HP, AHSP, F5, APOH, MTHFR, SERPINC1
25polyethylene glycol4510.5SERPINC1, BCHE, F5, SLC17A5, HP
26nicotine45 50 29 1113.5AHSP, SERPINE1, SERPINC1, GPT, BCHE, VWF
27ascorbic acid45 2411.5GSTP1, VWF, HP, F5, SERPINC1, MTHFR
28cyclophosphamide45 50 1112.5MTHFR, SERPINE1, BCHE, ADAMTS13, APOH, GSTP1
29glucose4510.5BCHE, AHSP, OTC, BNIP3, APOH, HADHA
30valproic acid45 50 11 2413.4EPHX2, GPT, SLC17A5, OTC, MTHFR
31methotrexate45 50 1112.4MTHFR, SLC17A5, GPT, SERPINE1, GSTP1, APOH
32sodium dodecylsulfate4510.4F5, HP, VWF, GSTP1, SERPINE1
33testosterone45 60 11 2413.4SERPINE1, SLC17A5, GSTP1, F5, VWF, HP
34arachidonic acid45 29 11 2413.4HADHA, HP, VWF, AHSP, EPHX2, LGALS13
35fibrinogen4510.4MTHFR, APOH, F5, ADAMTS13, SERPINC1, SERPINE1
36alanine4510.4HP, VWF, GPT, F5, GSTP1, SLC17A5
37cholesterol45 29 11 2413.4AHSP, SERPINE1, F5, APOH, SLC17A5, MTHFR
38lactate4510.4BCHE, BNIP3, APOH, HADHA, F5, HP
39aspirin45 50 29 2413.4SERPINC1, BCHE, GSTP1, SERPINE1, VWF, HADHA
40glutamine4510.4OTC, EPHX2, SLC17A5, GPT, VWF, HADHA
41hepaplastin4510.3GPT, SLC17A5, SERPINC1
42arginine4510.3BCHE, SERPINC1, OTC, GPT, GSTP1, F5
43ancrod4510.3SERPINC1, SERPINE1, F5
44atorvastatin45 50 29 11 2414.3SERPINE1, F5, VWF, GPT, SLC17A5
45nitric oxide45 11 2412.3BNIP3, SERPINE1, APOH, VWF, OTC, SLC17A5
46p0024510.3HP, APOH, F5, GPT, MTHFR
47creatinine4510.2SLC17A5, APOH, HADHA, F5, MTHFR, HP
48vegf4510.2SERPINE1, HP, SERPINC1, F5, GSTP1, APOH
49hirudin4510.2F5, SERPINC1, SERPINE1, VWF
50ximelagatran45 1111.0SERPINC1, GPT, F5

GO Terms for genes affiliated with Hellp Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Hellp Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:03109310.3SERPINE1, VWF, F5
2extracellular spaceGO:0056159.8ADAMTS13, APOH, F5, HP, SERPINE1, SERPINC1

Biological processes related to Hellp Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:05191810.4SERPINE1, APOH
2negative regulation of blood coagulationGO:03019510.4SERPINE1, APOH
3platelet activationGO:03016810.3ADAMTS13, SERPINE1, VWF, F5
4platelet degranulationGO:00257610.2F5, VWF, SERPINE1
5positive regulation of blood coagulationGO:03019410.1SERPINE1, APOH

Molecular functions related to Hellp Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00202010.3SERPINC1, SERPINE1, VWF
2hemoglobin bindingGO:03049210.1HP, AHSP

Products for genes affiliated with Hellp Syndrome

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  • Proteins
  • Lysates
  • Antibodies

Sources for Hellp Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet