MCID: HLL004
MIFTS: 53

Hellp Syndrome

Categories: Rare diseases, Blood diseases, Liver diseases, Reproductive diseases, Cardiovascular diseases

Aliases & Classifications for Hellp Syndrome

MalaCards integrated aliases for Hellp Syndrome:

Name: Hellp Syndrome 12 72 49 55 51 41 14 69
Hemolysis, Elevated Liver Enzymes, Low Platelets in Pregnancy 55
Hemolysis-Elevated Liver Enzymes-Low Platelets Syndrome 55
Hemolysis, Elevated Liver Enzymes, Lowered Platelets 49

Classifications:



External Ids:

Disease Ontology 12 DOID:13133
ICD10 32 O14.2
MeSH 41 D017359
NCIt 46 C84750
SNOMED-CT 64 199010001 95605009
Orphanet 55 ORPHA244242
MESH via Orphanet 42 D017359
UMLS via Orphanet 70 C0162739
ICD10 via Orphanet 33 O14.2
UMLS 69 C0162739

Summaries for Hellp Syndrome

NIH Rare Diseases : 49 HELLP syndrome is a life-threatening condition that can potentially complicate pregnancy. It is named for 3 features of the condition: Hemolysis, Elevated Liver enzyme levels, and Low Platelet levels. It typically occurs in the last 3 months of pregnancy (the third trimester) but can also start soon after delivery. A wide range of non-specific symptoms may be present in women with HELLP syndrome. Symptoms may include fatigue; malaise; fluid retention and excess weight gain; headache; nausea and vomiting; pain in the upper right or middle of the abdomen; blurry vision; and rarely, nosebleed or seizures. The cause of HELLP syndrome is not known, but certain risk factors have been associated with the condition. It is most common in women with preeclampsia or eclampsia. If not diagnosed and treated quickly, HELLP syndrome can lead to serious complications for the mother and baby. The main treatment is to deliver the baby as soon as possible, even if premature. Treatment may also include medications needed for the mother or baby, and blood transfusion for severe bleeding problems. Last updated: 5/2/2016

MalaCards based summary : Hellp Syndrome, also known as hemolysis, elevated liver enzymes, low platelets in pregnancy, is related to eclampsia and hepatic infarction. An important gene associated with Hellp Syndrome is HELLPAR (HELLP Associated Long Non-Coding RNA), and among its related pathways/superpathways are Formation of Fibrin Clot (Clotting Cascade) and Complement and coagulation cascades. The drugs Dexamethasone and Magnesium Sulfate have been mentioned in the context of this disorder. Affiliated tissues include liver, placenta and bone, and related phenotypes are homeostasis/metabolism and cardiovascular system

Disease Ontology : 12 A severe pre-eclampsia characterized by hemolysis, elevated liver enzyme and low platelet count.

Wikipedia : 72 HELLP syndrome is a life-threatening pregnancy complication usually considered to be a variant or... more...

Related Diseases for Hellp Syndrome

Diseases related to Hellp Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 223)
# Related Disease Score Top Affiliating Genes
1 eclampsia 30.6 F2 F5 FLT1 LGALS13 MTHFR PGF
2 hepatic infarction 30.4 APOH F2 HADHA MTHFR SERPINC1
3 antiphospholipid syndrome 30.4 ADAMTS13 APOH F2 F5 MTHFR SERPINC1
4 cholecystitis 30.3 F2 GPT HP
5 severe pre-eclampsia 30.2 APOH F5 LGALS13 PGF SERPINC1
6 nonarteritic anterior ischemic optic neuropathy 30.2 F2 F5 MTHFR SERPINC1
7 disseminated intravascular coagulation 30.0 ADAMTS13 F2 F5 SERPINC1 SERPINE1
8 purpura 30.0 ADAMTS13 APOH F2 SERPINC1 VWF
9 pre-eclampsia 29.9 APOH F2 F5 FLT1 LGALS13 MTHFR
10 placental insufficiency 29.9 F2 FLT1 PGF
11 thrombotic thrombocytopenic purpura, congenital 29.9 ADAMTS13 CFH HP
12 central retinal vein occlusion 29.8 APOH F2 F5 MTHFR SERPINC1
13 ischemic optic neuropathy 29.8 APOH F2 F5 MTHFR SERPINC1
14 hemolytic anemia 29.6 ADAMTS13 CFH CFI HP
15 thrombosis 29.5 APOH F2 F5 MTHFR SERPINC1 SERPINE1
16 thrombotic thrombocytopenic purpura 29.5 ADAMTS13 APOH CD46 CFH VWF
17 retinal vein occlusion 29.4 APOH F2 F5 MTHFR SERPINC1 SERPINE1
18 pulmonary embolism 29.4 APOH F2 F5 MTHFR SERPINC1 SERPINE1
19 hemolytic-uremic syndrome 29.4 ADAMTS13 CD46 CFH CFI VWF
20 thrombophilia 29.4 APOH F2 F5 MTHFR SERPINC1 SERPINE1
21 placental abruption 29.1 APOH F2 F5 FLT1 MTHFR PGF
22 arteries, anomalies of 29.0 F2 MTHFR PGF SERPINC1 SERPINE1 VWF
23 catastrophic antiphospholipid syndrome 28.9 ADAMTS13 APOH CFH F5 MTHFR SERPINE1
24 myocardial infarction 28.7 ADAMTS13 F2 F5 MTHFR PGF SERPINC1
25 preeclampsia/eclampsia 1 11.0
26 long-chain 3-hydroxyacyl-coa dehydrogenase deficiency 10.9
27 paracetamol poisoning 10.7 F2 F5
28 paraquat poisoning 10.6 GPT SLC17A5
29 hepatoportal sclerosis 10.6 F2 GPT
30 pyridoxine deficiency 10.6 GPT SLC17A5
31 mesenteric vascular occlusion 10.6 F2 MTHFR
32 porencephaly 10.6 F2 F5 MTHFR
33 kwashiorkor 10.6 F2 GPT SLC17A5
34 sagittal sinus thrombosis 10.6 F2 F5 SERPINC1
35 intestinal impaction 10.6 F2 SERPINC1
36 kidney cortex necrosis 10.6 GPT HADHA
37 arteritic anterior ischemic optic neuropathy 10.6 F2 F5 MTHFR
38 blood protein disease 10.6 F2 MTHFR SERPINC1
39 fournier gangrene 10.6 F2 SERPINC1
40 thrombasthenia 10.6 F2 F5 MTHFR
41 nonalcoholic steatohepatitis 10.6 F2 GPT SLC17A5
42 choledocholithiasis 10.6 F2 GPT SLC17A5
43 analbuminemia 10.6 F2 GPT SLC17A5
44 marantic endocarditis 10.6 F2 MTHFR SERPINC1
45 may-thurner syndrome 10.6 APOH F5
46 dysfibrinogenemia 10.6 F2 F5 SERPINC1
47 leech infestation 10.6 F2 SERPINC1
48 bile duct disease 10.5 F2 GPT HADHA
49 acanthamoeba keratitis 10.5 APOH F5
50 obstructive jaundice 10.5 F2 GPT SLC17A5

Graphical network of the top 20 diseases related to Hellp Syndrome:



Diseases related to Hellp Syndrome

Symptoms & Phenotypes for Hellp Syndrome

MGI Mouse Phenotypes related to Hellp Syndrome:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 F5 VWF FLT1 HADHA HP MTHFR
2 cardiovascular system MP:0005385 10 F5 VWF FLT1 HADHA HP PGF
3 mortality/aging MP:0010768 9.77 F5 VWF FLT1 HADHA HP MTHFR
4 vision/eye MP:0005391 9.23 FLT1 MTHFR ADAMTS13 PGF CD46 SERPINC1

Drugs & Therapeutics for Hellp Syndrome

Drugs for Hellp Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 98)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3 50-02-2 5743
2
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 7487-88-9 24083
3
Acetaminophen Approved Phase 4 103-90-2 1983
4
Ibuprofen Approved Phase 4 15687-27-1 3672
5
Cholecalciferol Approved, Nutraceutical Phase 4 67-97-0 10883523 5280795 6221
6
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
7
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
8 Hormone Antagonists Phase 4,Phase 3
9 Hormones Phase 4,Phase 3
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3
11 Calcium, Dietary Phase 4,Phase 3,Phase 2
12 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
13 Antiemetics Phase 4,Phase 3
14 Anti-Inflammatory Agents Phase 4,Phase 3
15 Antineoplastic Agents, Hormonal Phase 4,Phase 3
16 Autonomic Agents Phase 4,Phase 3,Phase 2
17 BB 1101 Phase 4,Phase 3
18 Dexamethasone acetate Phase 4,Phase 3 1177-87-3
19 Gastrointestinal Agents Phase 4,Phase 3,Phase 2
20 glucocorticoids Phase 4,Phase 3
21 HIV Protease Inhibitors Phase 4,Phase 3
22
protease inhibitors Phase 4,Phase 3
23 Follicle Stimulating Hormone Phase 4
24 Analgesics Phase 4,Phase 3,Phase 2
25 Anesthetics Phase 4,Phase 3,Phase 2
26 Anti-Arrhythmia Agents Phase 4,Phase 2,Phase 3
27 Anticonvulsants Phase 4,Phase 2,Phase 3
28 calcium channel blockers Phase 4,Phase 2,Phase 3
29 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
30 Tocolytic Agents Phase 4,Phase 2,Phase 3
31 Bone Density Conservation Agents Phase 4,Phase 3
32 Micronutrients Phase 4,Phase 3
33 Trace Elements Phase 4,Phase 3
34 Vitamins Phase 4,Phase 3
35 Pharmaceutical Solutions Phase 4,Phase 3
36 Analgesics, Non-Narcotic Phase 4,Phase 3
37 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
38 Antipyretics Phase 4,Phase 3
39 Antirheumatic Agents Phase 4,Phase 3
40 Cyclooxygenase Inhibitors Phase 4,Phase 3
41 Ergocalciferols Phase 4
42 Calciferol Nutraceutical Phase 4
43 Vitamin D2 Nutraceutical Phase 4
44
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
45
Dalteparin Approved Phase 3 9005-49-6
46
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
47
Insulin Aspart Approved Phase 3 116094-23-6 16132418
48
Insulin Detemir Approved Phase 3 169148-63-4 5311023
49
Zinc Approved, Investigational Phase 3 7440-66-6 32051 23994
50
Esomeprazole Approved, Investigational Phase 2, Phase 3 161796-78-7, 119141-88-7 9579578 4594

Interventional clinical trials:

(show all 32)

# Name Status NCT ID Phase Drugs
1 Efficacy of Corifollitropin Alfa Versus Follitropin Beta in Aged IVF (In-vitro Fertilization) Patients Completed NCT02466204 Phase 4 corifollitropin alfa;Follitropin Beta
2 Efficacy and Safety of 1 g Vs 2 g Per Hour Intravenous Maintenance Dose of MgSO4 in Women With Severe Pre-eclampsia Recruiting NCT03164304 Phase 4 Magnesium Sulfate
3 A Randomized Control Trial of Vitamin D Prophylaxis in the Prevention of Hypertensive Disorders of Pregnancy Recruiting NCT02920593 Phase 4 Vitamin D3
4 Effectivity of Postpartum Dexamethasone for Women With Class I HELLP Syndrome Active, not recruiting NCT00711841 Phase 4 dexamethasone;Placebo;dexamethasone
5 Effect of Acetaminophen on Postpartum Blood Pressure Control in Preeclampsia With Severe Features Active, not recruiting NCT02911701 Phase 4 Acetaminophen;Ibuprofen
6 Dexamethasone Efficacy in HELLP I Syndrome Unknown status NCT01138839 Phase 3 Dexamethasone;sterile water
7 Calcium for Pre-Eclampsia Prevention (CPEP) Completed NCT00000534 Phase 3 calcium
8 RCT of Antioxidant Therapy to Prevent Preeclampsia in Brazil Completed NCT00097110 Phase 3 Vitamin C and E
9 Prevention of Maternal and Perinatal Complications by Enoxaparin in Women With Previous Severe Preeclampsia Completed NCT00986765 Phase 3 Lovenox® (enoxaparin);Aspegic ® (Aspirin)
10 The Dutch STRIDER (Sildenafil TheRapy In Dismal Prognosis Early-onset Fetal Growth Restriction) Recruiting NCT02277132 Phase 2, Phase 3 Sildenafil;Placebo
11 Research Study Comparing Insulin Degludec to Insulin Detemir, Together With Insulin Aspart, in Pregnant Women With Type 1 Diabetes Recruiting NCT03377699 Phase 3 Insulin degludec;Insulin Aspart;Insulin detemir
12 Esomeprazole in Treatment of Early Onset Preeclampsia (ESOPE Trial) Not yet recruiting NCT03213639 Phase 2, Phase 3 Esomeprazole 40 mg Oral Tablet;Placebo Oral Tablet
13 Maternal and Neonatal Outcomes of the Use of Vasopressors to Treat Hypotension During Spinal Anesthesia for Cesarean Withdrawn NCT01451060 Phase 3 Metaraminol;Ephedrine
14 Labetalol Versus Magnesium Sulfate (MgSO4) for the Prevention of Eclampsia Trial Withdrawn NCT00293735 Phase 2, Phase 3 labetalol (seizure prevention);MgSO4 (seizure prevention)
15 Usefulness of Extracorporeal Removal of sFLT-1 in Women With Very Early Severe Preeclampsia Terminated NCT02286284 Phase 2
16 The SMART-ORACLE Study Unknown status NCT01932671
17 Promising Bimarker Prediction of Outcome of HELLP Syndrome. Completed NCT03246542
18 Immature Platelet Fraction as a Promising Biomarker in Prediction Outcome of HELLP Syndrome Completed NCT03232359
19 Platelet Count Trends in Pre-eclamptic Parturients Completed NCT00787241
20 A Study to Evaluate the Use of Placenta Protein 13 (PP13) in the First Trimester of Pregnancy as a Diagnostic Aiding Tool in the Assessment of the Risk for Developing Preeclampsia in Women With Low and Unknown Risk Completed NCT00572793
21 Risk Analysis of Intensive Care Mangement on Maternal and Fetal Outcome of Severe Preeclampsia and Eclampsia Completed NCT03412552 MgSO4
22 Doppler and Biological Second Trimester Placental Insufficiency Screening Completed NCT00465634
23 General Anesthesia Versus Spinal Anesthesia in Patients of HELLP Syndrome Recruiting NCT03111446
24 Influence of Conditional Workout Postpartum on Arterial Stiffness Among Women With Status After Preeclampsia, Superimposed Preeclampsia or HELLP-syndrome Recruiting NCT02754778
25 The Preeclampsia Registry Recruiting NCT02020174
26 Women Specific Cardiac Recovery After Preeclampsia Recruiting NCT02807324
27 Pancreatic Stone Protein (PSP) in Pregnant Women Recruiting NCT02247297
28 PC Protocol: Preconceptional Screening Recruiting NCT02309073
29 PREPARE, Prematurity Reduction by Pre-eclampsia Care Recruiting NCT03073317
30 sFlt-1:PlGF Ratio in Diagnosing Superimposed Preeclampsia Recruiting NCT03441711
31 Free DNA and Nucleosome Concentrations in Pathological Pregnancies Active, not recruiting NCT01736826
32 A Lifestyle Intervention to Improve in Vitro Fertilization Results Not yet recruiting NCT02648555

Search NIH Clinical Center for Hellp Syndrome

Cochrane evidence based reviews: hellp syndrome

Genetic Tests for Hellp Syndrome

Anatomical Context for Hellp Syndrome

MalaCards organs/tissues related to Hellp Syndrome:

38
Liver, Placenta, Bone, Endothelial, Brain, Testes, Kidney

Publications for Hellp Syndrome

Articles related to Hellp Syndrome:

(show top 50) (show all 627)
# Title Authors Year
1
Role and mechanism of AT1-AA in the pathogenesis of HELLP syndrome. ( 29321548 )
2018
2
HELLP syndrome, risk factors in first and second pregnancy: a population-based cohort study. ( 29430625 )
2018
3
HELLP syndrome in a pregnant patient with Gitelman syndrome. ( 28393002 )
2017
4
Diagnosis and Management of HELLP Syndrome Complicated by Liver Hematoma. ( 28005587 )
2017
5
Description of a strong relationship among total cell-free DNA levels, LDH values, AST values and platelet count in patients with HELLP syndrome. ( 28331215 )
2017
6
Maternal bradycardia occurring prior to onset of HELLP syndrome in a woman with pre-eclampsia. ( 28501825 )
2017
7
Intensive Care Unit issues in eclampsia and HELLP syndrome. ( 28971026 )
2017
8
Severe reduction of free-form ADAMTS13, unbound to von Willebrand factor, in plasma of patients with HELLP syndrome. ( 29296808 )
2017
9
Pravastatin for prevention of HELLP syndrome: A case report. ( 29049209 )
2017
10
Massive Hepatic Infarction Caused by HELLP Syndrome. ( 28670595 )
2017
11
Conservative versus active management in HELLP syndrome: results from a cohort study. ( 29228827 )
2017
12
Life-threatening bleeding from gastric dieulafoy's lesion in a pregnant woman with hellp syndrome: a case report and literature review. ( 28760134 )
2017
13
Haemophagocytic lymphohistiocytosis presenting as HELLP syndrome: a diagnostic and therapeutic challenge. ( 28433984 )
2017
14
Factors contributing to adverse maternal outcomes in patients with HELLP syndrome. ( 28784005 )
2017
15
Microcirculatory blood flow derangements during severe preeclampsia and HELLP syndrome. ( 29153664 )
2017
16
Hematoma After Transversus Abdominis Plane Block in a Patient With HELLP Syndrome: A Case Report. ( 28252541 )
2017
17
Color vision abnormality as the sole manifestation of posterior reversible encephalopathy due to post-partum HELLP syndrome. ( 28109137 )
2017
18
SWEPT SOURCE OPTICAL COHERENCE TOMOGRAPHY EVALUATION OF CHORIORETINAL CHANGES IN HYPERTENSIVE CHOROIDOPATHY RELATED TO HELLP SYNDROME. ( 28067720 )
2017
19
Maternal cardiac function after HELLP syndrome: an echocardiography study. ( 28971558 )
2017
20
Recurrent HELLP Syndrome at 22 Weeks of Gestation. ( 28929001 )
2017
21
Importance of correctly interpreting magnetic resonance imaging to diagnose posterior reversible encephalopathy syndrome associated with HELLP syndrome: a case report. ( 28545408 )
2017
22
Dysregulation of the Fas/FasL system in an experimental animal model of HELLP syndrome. ( 28501275 )
2017
23
A Case Report of the Nutrition Support for a Patient with HELLP Syndrome. ( 28503510 )
2017
24
Total and Fetal Circulating Cell-Free DNA, Angiogenic, and Antiangiogenic Factors in Preeclampsia and HELLP Syndrome. ( 28338787 )
2017
25
Elevated systemic galectin-1 levels characterize HELLP syndrome. ( 26956510 )
2016
26
Postpartum high fever and imitators of HELLP syndrome. ( 27590211 )
2016
27
Pre- and intraretinal haemorrhages in a 22-week-old fetus of a mother suffering from HELLP syndrome and factor V Leiden mutation with deep vein thrombosis. ( 27229627 )
2016
28
Postpartum corticosteroids in HELLP syndrome - standard to prompt recovery. ( 27546544 )
2016
29
Are there any additional mechanisms for haemolysis in HELLP syndrome? ( 27128171 )
2016
30
Anesthesia in pregnant women with HELLP syndrome: case report. ( 27793243 )
2016
31
No Hypertensive Disorder of Pregnancy; No Preeclampsia-eclampsia; No Gestational Hypertension; No Hellp Syndrome. Vascular Disorder of Pregnancy Speaks for All. ( 27222631 )
2016
32
Hepatic Artery Embolization for Hepatic Rupture in HELLP Syndrome. ( 27886958 )
2016
33
HELLP Syndrome: Altered Hypoxic Response of the Fatty Acid Oxidation Regulator SIRT 4. ( 27651178 )
2016
34
Author's reply re: Microcirculation in women with severe pre-eclampsia and HELLP syndrome: a case control study. ( 27531337 )
2016
35
CHOROIDAL MORPHOLOGY IN A PATIENT WITH HELLP SYNDROME. ( 26595148 )
2016
36
Anesthetic practices for patients with preeclampsia or HELLP syndrome: A survey. ( 27651719 )
2016
37
A comparison of the diagnostic utility of the sFlt-1/PlGF ratio versus PlGF alone for the detection of preeclampsia/HELLP syndrome. ( 27028698 )
2016
38
Late postpartum HELLP syndrome over 10 days after delivery. ( 27260549 )
2016
39
A HELLP syndrome complicates a gestational trophoblastic neoplasia in a perimenopausal woman: a case report. ( 27485461 )
2016
40
Maternal-fetal prognosis in HELLP syndrome in a level 3 maternal-fetal care centre. ( 27328494 )
2016
41
A Hat-Trick Knock-Reversible Triple Organ Injury in a New Mother With HELLP Syndrome. ( 27755233 )
2016
42
Transfusion Related Acute Lung Injury after Cesarean Section in a Patient with HELLP Syndrome. ( 26885326 )
2016
43
Re: Microcirculation in women with severe pre-eclampsia and HELLP syndrome: a case control study: Effect of timing of extracorporeal membrane oxygenation during HELLP syndrome. ( 27531338 )
2016
44
The placental component and obstetric outcome in severe preeclampsia with and without HELLP syndrome. ( 27780546 )
2016
45
Direct evidence of complement activation in HELLP syndrome: A link toA atypical hemolytic uremic syndrome. ( 26921648 )
2016
46
Brain abscess due to Listeria monocytogenes after HELLP syndrome in a patient with antiphospholipid syndrome. ( 27927881 )
2016
47
Resolution of HELLP syndrome after selective feticide for trisomy 21 in discordant twins - A case report. ( 26804722 )
2016
48
Reply: Postpartum high fever and imitators of HELLP syndrome. ( 27592726 )
2016
49
Scrub typhus masquerading as HELLP syndrome and puerperal sepsis in an asymptomatic malaria patient. ( 27413718 )
2016
50
Maternal cardiac function after HELLP syndrome: an echocardiographic study. ( 27854396 )
2016

Variations for Hellp Syndrome

Expression for Hellp Syndrome

Search GEO for disease gene expression data for Hellp Syndrome.

Pathways for Hellp Syndrome

GO Terms for Hellp Syndrome

Cellular components related to Hellp Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.9 APOH CD46 CFH CFI F2 GPT
2 extracellular region GO:0005576 9.77 ADAMTS13 APOH CFH CFI F2 F5
3 endoplasmic reticulum lumen GO:0005788 9.71 ADAMTS13 F2 F5 SERPINC1
4 blood microparticle GO:0072562 9.56 CFH F2 HP SERPINC1
5 platelet alpha granule lumen GO:0031093 9.5 F5 SERPINE1 VWF
6 extracellular space GO:0005615 9.44 ADAMTS13 APOH CFH CFI F2 F5
7 platelet alpha granule GO:0031091 9.37 F5 VWF

Biological processes related to Hellp Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 9.73 APOH F5 SERPINE1 VWF
2 blood coagulation GO:0007596 9.72 ADAMTS13 F2 F5 SERPINC1 VWF
3 regulation of complement activation GO:0030449 9.71 CD46 CFH CFI F2
4 regulation of blood coagulation GO:0030193 9.54 APOH F2 SERPINC1
5 negative regulation of blood coagulation GO:0030195 9.46 APOH SERPINE1
6 blood coagulation, intrinsic pathway GO:0007597 9.43 APOH F2 VWF
7 positive regulation of blood coagulation GO:0030194 9.33 APOH F2 SERPINE1
8 negative regulation of fibrinolysis GO:0051918 9.13 APOH F2 SERPINE1
9 hemostasis GO:0007599 9.02 ADAMTS13 F2 F5 SERPINC1 VWF

Molecular functions related to Hellp Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.13 SERPINC1 SERPINE1 VWF
2 heparin binding GO:0008201 9.02 APOH CFH F2 PGF SERPINC1

Sources for Hellp Syndrome

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10 dbSNP
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