MCID: HLL004
MIFTS: 54

Hellp Syndrome malady

Rare diseases, Blood diseases, Cardiovascular diseases, Liver diseases categories

Summaries for Hellp Syndrome

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44NIH Rare Diseases, 66Wikipedia, 34MalaCards
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NIH Rare Diseases:44 Hellp syndrome is a rare but serious illness in pregnancy. this condition can start quickly, most often in the last 3 months of pregnancy (the third trimester). it can also start soon after the baby is delivered. hellp stands for hemolysis, elevated liver enzyme levels and a low platelet count. these problems are often found in women with this syndrome. these problems, along with the high blood pressure commonly found in association with hellp syndrome, can lead to problems for both the mother and the baby. many cases of hellp syndrome are associated with  preeclampsia or eclampsia. the exact cause of hellp syndrome remains unknown, making it difficult to determine which women will be affected. treatment may involve medication and/or delivery of the baby.    last updated: 1/26/2010

MalaCards: Hellp Syndrome, also known as syndrome of haemolysis, elevated liver enzymes and low platelet, is related to eclampsia and pre-eclampsia. An important gene associated with Hellp Syndrome is HADHA (hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit), and among its related pathways are Complement and coagulation cascades and Formation of Fibrin Clot (Clotting Cascade). The compounds inogatran and hirugen have been mentioned in the context of this disorder. Affiliated tissues include liver, placenta and testes, and related mouse phenotypes are liver/biliary system and homeostasis/metabolism.

Wikipedia:66 HELLP syndrome is a life-threatening obstetric complication usually considered to be a variant or... more...

Aliases & Classifications for Hellp Syndrome

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9Disease Ontology, 44NIH Rare Diseases, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 26ICD10
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Classifications:



Aliases & Descriptions:

hellp syndrome 9 44 46 63
syndrome of haemolysis, elevated liver enzymes and low platelet 9
hemolysis, elevated liver enzymes, lowered platelets 44


External Ids:

Disease Ontology9 DOID:13133
NCIt41 C84750
SNOMED-CT59 199010001, 95605009
MeSH36 D017359
ICD1026 O14.2

Related Diseases for Hellp Syndrome

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Hellp Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 134)
idRelated DiseaseScoreTop Affiliating Genes
1eclampsia31.4SERPINC1
2pre-eclampsia30.8ADAMTS13, SLC17A5, F5, HP, HADHA, APOH
3antiphospholipid syndrome30.7F5, ADAMTS13, APOH, SERPINC1
4severe pre-eclampsia30.7SERPINC1, F5, APOH
5purpura30.5ADAMTS13, SERPINC1
6lupus erythematosus30.5APOH, SERPINC1, F5
7pancreatitis30.5BCHE, SLC17A5
8thrombophilia30.3APOH, SERPINC1, F5
9thrombocytopenia30.3SLC17A5, BCHE, HP, APOH, F5, ADAMTS13
10disseminated intravascular coagulation30.2F5, ADAMTS13, SERPINC1
11myocardial infarction30.2F5, ADAMTS13, SERPINC1
12hemolytic anemia30.2HP, APOH, ADAMTS13
13proteinuria30.2ADAMTS13, HP, APOH
14placental abruption30.1SERPINC1, F5
15acute kidney failure30.1ADAMTS13, HP
16central retinal vein occlusion30.0F5, APOH
17cystic fibrosis30.0BCHE, HADHA, HP
18coronary artery disease30.0HP, BCHE, ADAMTS13
19lupus nephritis30.0APOH, ADAMTS13
20ischemia30.0ADAMTS13, SLC17A5, HP
21retinal vein occlusion30.0APOH, SERPINC1, F5
22hepatitis10.8
23hypertension10.6
24retinitis10.5
25retinal detachment10.5
26systemic lupus erythematosus10.4
27blindness10.4
28diabetes insipidus10.3
29cerebritis10.3
30acute fatty liver of pregnancy10.3
31endotheliitis10.3
32thrombotic thrombocytopenic purpura10.2
33cortical blindness10.2
34acute pancreatitis10.2
35hemolytic-uremic syndrome10.2
36pulmonary edema10.2
37cholecystitis10.2
38glomerulonephritis10.2
39triploidy10.2
40hellp syndrome, maternal, of pregnancy10.2
41nephritis10.2
42coronary thrombosis10.1SERPINC1
43cholangitis10.1SLC17A5
44branch retinal artery occlusion10.1F5
45patent foramen ovale10.1F5
46evans' syndrome10.1ADAMTS13
47retinal artery occlusion10.1APOH
48thrombophlebitis10.1APOH
49congenital disorder of glycosylation type 1a10.1SERPINC1, HP
50splenomegaly10.1SLC17A5, HP

Graphical network of the top 20 diseases related to Hellp Syndrome:



Diseases related to hellp syndrome

Symptoms for Hellp Syndrome

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Drugs & Therapeutics for Hellp Syndrome

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Hellp Syndrome

Drug clinical trials:

Search ClinicalTrials for Hellp Syndrome

Search NIH Clinical Center for Hellp Syndrome

Search CenterWatch for Hellp Syndrome

Genetic Tests for Hellp Syndrome

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Anatomical Context for Hellp Syndrome

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34MalaCards
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MalaCards organs/tissues related to Hellp Syndrome:

34
Liver, Placenta, Testes, Endothelial, Kidney, Brain, Bone, Myeloid, Cervix, Bone marrow, Uterus, Skin, Lung, Pituitary

Animal Models for Hellp Syndrome or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Hellp Syndrome:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.8F5, HP, SERPINC1, HADHA
2MP:00053766.3SLC17A5, HADHA, APOH, SERPINC1, ADAMTS13, HP
3MP:00107686.1HADHA, APOH, SERPINC1, ADAMTS13, HP, BCHE

Publications for Hellp Syndrome

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Sources:
53PubMed
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Articles related to Hellp Syndrome:

(show top 50)    (show all 508)
idTitleAuthorsYear
1
Changes of placental syndecan-1 expression in preeclampsia and HELLP syndrome. (23807541)
2013
2
COHELLP: collaborative randomized controlled trial on corticosteroids in HELLP syndrome. (23697398)
2013
3
HELLP syndrome and its relation with the antiphospholipid syndrome. (24333078)
2013
4
Good outcome in HELLP syndrome with lobar cerebral hematomas. (21161697)
2011
5
Use of recombinant human soluble thrombomodulin in the management of HELLP syndrome complicated by DIC. (20627281)
2010
6
The HELLP syndrome. (20491358)
2010
7
Leptin receptor (LEPR) SNP polymorphisms in HELLP syndrome patients determined by quantitative real-time PCR and melting curve analysis. (20149225)
2010
8
Gestational diabetes insipidus, HELLP syndrome and eclampsia in a twin pregnancy: a case report. (20118941)
2010
9
Maternal deaths due to eclampsia and HELLP syndrome. (19027902)
2009
10
ABO incompatible liver transplantation as a bridge to treat HELLP syndrome. (19794830)
2009
11
Prevalence rate of acute renal failure in HELLP syndrome: a summary from a single country's data. (19839862)
2009
12
Bilateral serous retinal detachment in a woman with HELLP syndrome HELLP syndrome and retinal detachment. (19358039)
2009
13
Ketonuria and HELLP syndrome. (21686464)
2009
14
The HELLP syndrome, antiphospholipid antibodies, and syndromes. (17912576)
2008
15
Mannose-binding lectin (MBL) codon 54 gene polymorphism protects against development of pre-eclampsia, HELLP syndrome and pre-eclampsia-associated intrauterine growth restriction. (17314117)
2007
16
Dexamethasone, HELLP syndrome, and study design. (16677590)
2006
17
Characteristics and treatment of hepatic rupture caused by HELLP syndrome. (16579935)
2006
18
Argon beam coagulator for treatment of hepatic rupture with hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome. (16449174)
2006
19
Addition of platelet transfusions to corticosteroids does not increase the recovery of severe HELLP syndrome. (16388885)
2006
20
Neonatal outcome after preterm delivery in HELLP syndrome. (16807990)
2006
21
Lack of association between the CYP11B2 gene polymorphism and preeclampsia, eclampsia, and the HELLP syndrome in Turkish women. (16303227)
2006
22
Understanding and managing HELLP syndrome: the integral role of aggressive glucocorticoids for mother and child. (16631593)
2006
23
The transplacental passage of prednisolone in pregnancies complicated by early-onset HELLP syndrome. (16226134)
2005
24
Dexamethasone treatment does not improve the outcome of women with HELLP syndrome: a double-blind, placebo-controlled, randomized clinical trial. (16260197)
2005
25
Pseudocholinesterase deficiency associated with HELLP syndrome. (15311366)
2004
26
Case of HELLP syndrome with an unusual presentation. (15242509)
2004
27
Pregnancy complicated by HELLP syndrome]. (15884197)
2004
28
The effect of glyceryl trinitrate on hypertension in women with severe preeclampsia, HELLP syndrome, and eclampsia. (15117599)
2004
29
Dexamethasone compared with betamethasone for glucocorticoid treatment of postpartum HELLP syndrome. (12628531)
2003
30
HELLP syndrome complicated by visual loss. (12963522)
2003
31
A case of postpartum cerebellar infarction with hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome. (12186992)
2002
32
The impact of parity on the incidence of HELLP syndrome and small for gestational age infants in hypertensive pregnant women. (12196855)
2002
33
HELLP syndrome and factor V Leiden. (11267721)
2001
34
Time course of recovery and complications of HELLP syndrome with two different treatments: heparin or dexamethasone. (11323019)
2001
35
Doppler sonographic findings for hypertension in pregnancy and HELLP syndrome. (10642960)
1999
36
Altered lipid metabolism in preeclampsia and HELLP syndrome: links to enhanced platelet reactivity and fetal growth. (10625202)
1999
37
HELLP syndrome: recognition and perinatal management. (10498110)
1999
38
A review of HELLP syndrome. (10642976)
1999
39
Relation between gestational thrombocytopenia and the syndrome of hemolysis, elevated liver enzymes, and low platelet count (HELLP syndrome). (9692341)
1998
40
HELLP syndrome: undiagnosed in a case of impending rupture of uterus. A case report. (9859107)
1998
41
Obstetrical anaesthesia for a parturient with preeclampsia, HELLP syndrome and acute cortical blindness. (9598260)
1998
42
Thrombocytopenia in preeclampsia: an earlier detector of HELLP syndrome. (9361486)
1997
43
Ethnic variation in the incidence of HELLP syndrome in a hypertensive pregnant population. (9494922)
1997
44
HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets) pathophysiology and anesthetic considerations. (9223938)
1997
45
Lactate dehydrogenase isoenzymes in patients with HELLP syndrome]. (8963883)
1996
46
Plasma exchange for preeclampsia: III. Immediate peripartal utilization for selected patients with HELLP syndrome. (7706196)
1994
47
An atypical case of hemolysis, elevated liver enzymes and low platelet count (HELLP) syndrome. (7907061)
1994
48
HELLP syndrome: a variant of severe preeclampsia. (8196820)
1994
49
Neonatal salvage by week's gestation in pregnancies complicated by HELLP syndrome. (9419772)
1994
50
The Hellp syndrome. Clinical and laboratory test results]. (1631474)
1992

Variations for Hellp Syndrome

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Expression for genes affiliated with Hellp Syndrome

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hellp Syndrome

Search GEO for disease gene expression data for Hellp Syndrome.

Pathways for genes affiliated with Hellp Syndrome

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51PathCards, 31KEGG, 39NCBI BioSystems Database, 56Reactome, 54QIAGEN, 55R&D Systems
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Pathways related to Hellp Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Complement Activation, Classical Pathway39
Complement and Coagulation Cascades39
9.5F5, SERPINC1
2
Show member pathways
9.5F5, SERPINC1

Compounds for genes affiliated with Hellp Syndrome

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46Novoseek, 12DrugBank, 62Tocris Bioscience, 30IUPHAR, 25HMDB, 52PharmGKB
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Compounds related to Hellp Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 127)
idCompoundScoreTop Affiliating Genes
1inogatran469.8SERPINC1, F5
2hirugen469.8SERPINC1, F5
3ecarin469.8SERPINC1, F5
4hepaplastin469.8SLC17A5, SERPINC1
5spectrozyme469.7F5, SERPINC1
6nafamostat mesilate469.6F5, SERPINC1
7danaparoid469.6SERPINC1, F5
8ximelagatran46 1210.5SERPINC1, F5
9levonorgestrel46 62 30 1212.5SLC17A5, F5, SERPINC1
10vitamin-e469.4SLC17A5, HP, F5
11aprotinin46 1210.3F5, SLC17A5, SERPINC1
12ristocetin469.3F5, SERPINC1, ADAMTS13
13desmopressin46 62 30 1212.2ADAMTS13, SERPINC1, F5
14ancrod469.2SERPINC1, F5
15citrate469.2HP, HADHA, SERPINC1, F5
16tween 20469.1BCHE, APOH
17ascorbic acid46 2510.1HP, SLC17A5, F5, SERPINC1
18kaolin469.0APOH, F5
19dextran sulfate469.0F5, SERPINC1, APOH
20warfarin46 52 25 1212.0F5, APOH, SERPINC1
21ticlopidine46 1210.0SERPINC1, ADAMTS13, APOH
22rituximab46 52 1211.0HP, ADAMTS13, APOH
23urea46 25 1211.0ADAMTS13, HP, F5, SLC17A5
24nacl468.9ADAMTS13, F5, HP, SLC17A5
25vitamin b12468.8HP, APOH, F5, SLC17A5
26malondialdehyde468.8F5, SLC17A5, HP, APOH
27uric acid46 259.8HP, SLC17A5, F5, APOH
28kininogen468.7APOH, F5, HP, SERPINC1
29homocysteine46 259.7HP, F5, APOH, SERPINC1
30polyacrylamide468.7HP, SLC17A5, F5, APOH
31prostacyclin468.7SERPINC1, F5, HADHA, APOH
32ethanol46 52 25 1211.7BCHE, SLC17A5, HP, APOH
33phospholipid468.7SLC17A5, F5, APOH, HP
34polyethylene glycol468.6SERPINC1, BCHE, F5, SLC17A5, HP
35pge1468.6APOH, F5, SLC17A5, BCHE
36cocaine46 129.6F5, BCHE, APOH, SLC17A5
37fatty acid468.6BCHE, SLC17A5, APOH, HADHA
38cyclophosphamide46 52 1210.4F5, BCHE, ADAMTS13, APOH
39folate468.3F5, SLC17A5, HP, SERPINC1, APOH
40glucose468.3HP, HADHA, APOH, SLC17A5, BCHE
41alanine468.3F5, SLC17A5, BCHE, SERPINC1, HADHA, HP
42endotoxin468.2SLC17A5, HP, ADAMTS13, APOH, F5
43serine468.0SERPINC1, HP, BCHE, F5, HADHA, ADAMTS13
44lactate467.9HP, HADHA, BCHE, APOH, F5, SLC17A5
45glutamate467.9HADHA, F5, SLC17A5, APOH, BCHE, HP
46aspirin46 52 30 2510.9HP, BCHE, F5, SERPINC1, APOH, HADHA
47fibrinogen467.7SERPINC1, SLC17A5, F5, HP, APOH, ADAMTS13
48calcium46 52 25 1210.4HADHA, APOH, HP, BCHE, ADAMTS13, F5
49heparin46 30 25 1210.2SLC17A5, SERPINC1, APOH, ADAMTS13, HP, BCHE
50creatinine466.9BCHE, HP, ADAMTS13, SERPINC1, F5, HADHA

GO Terms for genes affiliated with Hellp Syndrome

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17Gene Ontology
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Cellular components related to Hellp Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1blood microparticleGO:0725628.8SERPINC1, HP, BCHE
2extracellular regionGO:0055768.6F5, BCHE, HP, SERPINC1
3extracellular spaceGO:0056157.1F5, BCHE, HP, ADAMTS13, SERPINC1, APOH

Molecular functions related to Hellp Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1catalytic activityGO:0038249.6BCHE, HP

Products for genes affiliated with Hellp Syndrome

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Sources for Hellp Syndrome

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet