MCID: HLL004
MIFTS: 57

Hellp Syndrome malady

Liver diseases, Blood diseases categories

Summaries for Hellp Syndrome

About this section
Sources:
42NIH Rare Diseases, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NIH Rare Diseases:42 Hellp syndrome is a rare but serious illness in pregnancy. this condition can start quickly, most often in the last 3 months of pregnancy (the third trimester). it can also start soon after the baby is delivered. hellp stands for hemolysis, elevated liver enzyme levels and a low platelet count. these problems are often found in women with this syndrome. these problems, along with the high blood pressure commonly found in association with hellp syndrome, can lead to problems for both the mother and the baby. many cases of hellp syndrome are associated with  preeclampsia or eclampsia. the exact cause of hellp syndrome remains unknown, making it difficult to determine which women will be affected. treatment may involve medication and/or delivery of the baby.    last updated: 1/26/2010

MalaCards: Hellp Syndrome, also known as syndrome of haemolysis, elevated liver enzymes and low platelet, is related to eclampsia and hepatitis. An important gene associated with Hellp Syndrome is HADHA (hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit), and among its related pathways are Platelet degranulation and Complement and coagulation cascades. The compounds estrogen and warfarin have been mentioned in the context of this disorder. Affiliated tissues include liver, placenta and endothelial, and related mouse phenotypes are liver/biliary system and cardiovascular system.

Wikipedia:63 HELLP syndrome is a life-threatening obstetric complication usually considered to be a variant or... more...

Aliases & Classifications for Hellp Syndrome

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 44Novoseek, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Liver diseases, Blood diseases


Aliases & Descriptions:

hellp syndrome 8 42 44 60
syndrome of haemolysis, elevated liver enzymes and low platelet 8
hemolysis, elevated liver enzymes, lowered platelets 42


External Ids:

Disease Ontology8 DOID:13133
NCIt39 C84750
SNOMED-CT56 199010001, 95605009
MeSH34 D017359
ICD1025 O14.2

Related Diseases for Hellp Syndrome

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Hellp Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 212)
idRelated DiseaseScoreTop Affiliating Genes
1eclampsia31.2MTHFR, SERPINC1
2hepatitis31.1SLC17A5, GPT
3pre-eclampsia31.1APOH, HADHA, F5, MTHFR, EPHX2, AHSP
4antiphospholipid syndrome30.9APOH, F5, MTHFR, VWF, SERPINC1, ADAMTS13
5hypertension30.8EPHX2, SERPINE1, MTHFR, F5
6severe pre-eclampsia30.7APOH, F5, SERPINE1, SERPINC1, GSTP1
7thrombocytopenia30.6APOH, F5, HP, VWF, GPT, SLC17A5
8lupus erythematosus30.5SERPINC1, F5, APOH
9purpura30.4SERPINC1, ADAMTS13
10pancreatitis30.4SLC17A5, BCHE, GSTP1
11acute pancreatitis30.3SLC17A5, GPT
12hemolytic anemia30.3APOH, HP, VWF, ADAMTS13
13thrombophilia30.3APOH, F5, MTHFR, VWF, SERPINE1, SERPINC1
14hemolytic-uremic syndrome30.2ADAMTS13, VWF
15proteinuria30.2ADAMTS13, HP, APOH
16disseminated intravascular coagulation30.2F5, SERPINE1, SERPINC1, ADAMTS13
17myocardial infarction30.1F5, MTHFR, AHSP, ADAMTS13, SERPINC1, SERPINE1
18malaria29.9ADAMTS13, HP
19sarcoma29.9GSTP1
20central retinal vein occlusion29.9APOH, F5, MTHFR
21portal vein thrombosis29.9F5, MTHFR, SERPINC1
22hepatitis b29.9GPT, SLC17A5
23cystic fibrosis29.9BCHE, OTC, HP, HADHA
24retinal vein occlusion29.9APOH, F5, MTHFR, SERPINC1
25placental abruption29.9F5, MTHFR, SERPINC1
26glucose intolerance29.9GPT, SERPINE1
27hepatic vein thrombosis29.9SERPINC1, SERPINE1
28ischemia29.9ADAMTS13, SLC17A5, HP, AHSP, BNIP3
29acute kidney failure29.9ADAMTS13, GPT, HP
30leukemia29.9MTHFR, HP, OTC, BCHE, GSTP1
31coronary artery disease29.9MTHFR, AHSP, HP, VWF, SERPINE1, BCHE
32hepatitis a10.5
33retinitis10.5
34retinal detachment10.4
35systemic lupus erythematosus10.3
36image syndrome10.3
37cerebritis10.3
38diabetes insipidus10.3
39thrombotic thrombocytopenic purpura10.2
40cortical blindness10.2
41infarct of liver10.2
42pulmonary edema10.1
43cholecystitis10.1
44glomerulonephritis10.1
45hellp syndrome, maternal, of pregnancy10.1
46retinal artery occlusion10.0APOH
47ovarian hyperstimulation syndrome10.0F5
48pneumonia10.0BCHE
49alpha thalassemia10.0AHSP
50dementia10.0BCHE

Graphical network of the top 20 diseases related to Hellp Syndrome:



Diseases related to hellp syndrome

Clinical Features for Hellp Syndrome

About this section

Drugs & Therapeutics for Hellp Syndrome

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Hellp Syndrome

Drug clinical trials:

Search ClinicalTrials for Hellp Syndrome

Search NIH Clinical Center for Hellp Syndrome

Search CenterWatch for Hellp Syndrome

Genetic Tests for Hellp Syndrome

About this section

Anatomical Context for Hellp Syndrome

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Hellp Syndrome:

32
Liver, Placenta, Endothelial, Testes, Kidney, Brain, Bone, Myeloid, Cervix, Bone marrow, Uterus, Skin, Lung, Spinal cord, Pituitary

Animal Models for Hellp Syndrome or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Hellp Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000537010.2SERPINC1, SERPINE1, OTC, HP, F5, HADHA
2MP:000538510.0BNIP3, HADHA, EPHX2, HP
3MP:00053769.8ADAMTS13, BNIP3, APOH, HADHA, F5, MTHFR
4MP:00107689.7AHSP, MTHFR, F5, HADHA, APOH, HP

Publications for Hellp Syndrome

About this section
Sources:
50PubMed
See all sources

Articles related to Hellp Syndrome:

(show top 50)    (show all 523)
idTitleAuthorsYear
1
Microcirculation in women with severe pre-eclampsia and HELLP syndrome: a case-control study. (24206102)
2014
2
Changes of placental syndecan-1 expression in preeclampsia and HELLP syndrome. (23807541)
2013
3
Human placental macrophages (Hofbauer cells) in severe preeclampsia complicated by HELLP syndrome: immunohistochemistry of chorionic villi. (24282909)
2013
4
Inability to have children caused by recurrent HELLP syndrome in early pregnancies - implications for a review of literature. (24285462)
2013
5
HELLP syndrome: understanding and management of a pregnancy-specific disease. (23654309)
2013
6
ADAMTS13 deficiency in severe postpartum HELLP syndrome. (23889130)
2013
7
Choice of glucocorticoid in HELLP syndrome - dexamethasone versus betamethasone: revisiting the dilemma. (22839431)
2012
8
A case of HELLP syndrome: an immuno-"logical" approach. (23189549)
2012
9
Acute oliguric renal failure in HELLP syndrome: case report and review of literature. (22364519)
2012
10
Comparison of placental pathology between severe preeclampsia and HELLP syndrome. (21698449)
2012
11
Extensive hepatic infarction in severe preeclampsia as part of the HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): evolution of CT findings and successful treatment with plasma exchange therapy. (23040928)
2012
12
HELLP syndrome: 8 years of experience from a tertiary referral center in western Turkey. (20822425)
2012
13
Early pancreatic panniculitis associated with HELLP syndrome and acute fatty liver of pregnancy. (21752052)
2011
14
Recurrence risks of hypertensive diseases in pregnancy after HELLP syndrome. (21809897)
2011
15
Leptin receptor (LEPR) SNP polymorphisms in HELLP syndrome patients determined by quantitative real-time PCR and melting curve analysis. (20149225)
2010
16
Gestational diabetes insipidus, HELLP syndrome and eclampsia in a twin pregnancy: a case report. (20118941)
2010
17
Spinal subarachnoid hematoma following spinal anesthesia in a patient with HELLP syndrome. (19945267)
2010
18
ABO incompatible liver transplantation as a bridge to treat HELLP syndrome. (19794830)
2009
19
Leptin gene (TTTC)(n) microsatellite polymorphism in pre-eclampsia and HELLP syndrome. (19634986)
2009
20
Maternal and fetal outcome of pregnancy complicated by HELLP syndrome. (19916711)
2009
21
Beyond preeclampsia: HELLP syndrome. (18399053)
2008
22
HELLP syndrome--a pregnancy disorder with poor prognosis. (19558067)
2008
23
Association of HELLP syndrome with primary antiphospholipid syndrome--a case report. (17684701)
2008
24
HELLP syndrome - a multisystemic disorder. (18193124)
2007
25
Liver transplantation for HELLP syndrome. (17983071)
2007
26
Characteristics and treatment of hepatic rupture caused by HELLP syndrome. (16579935)
2006
27
Liver transplantation of a HELLP syndrome donor liver in acute fulminant hepatitis B with deltavirus coinfection. (17081235)
2006
28
Two cases of HELLP syndrome with fatal outcomes. (17089584)
2006
29
Placental expression of nitric oxide synthase during HELLP syndrome: the correlation with maternal-fetal Doppler velocimetry. (16097974)
2005
30
Corticosteroids, pregnancy, and HELLP syndrome: a review. (15618920)
2005
31
Controversies with the diagnosis and management of HELLP syndrome. (15805802)
2005
32
Lack of correlation between fatty acid oxidation disorders and haemolysis, elevated liver enzymes, low platelets (HELLP) syndrome? (15858960)
2005
33
Lack of common mutation in the alfa-subunit of the mitochondrial trifunctional protein and the polymorphism of CYP2E1 in three Japanese women with acute fatty liver of pregnancy/HELLP syndrome. (15589131)
2004
34
Subsequent pregnancy outcome in women with a history of HELLP syndrome at < or = 28 weeks of gestation. (12824985)
2003
35
The maternal benefits of corticosteroids with HELLP (hemolysis, elevated liver enzymes, low platelet count) syndrome. (12908017)
2003
36
Severe folate deficiency mimicking HELLP syndrome--report of two cases. (12841505)
2003
37
Hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome as a complication of preeclampsia in pregnant women increases the amount of cell-free fetal and maternal DNA in maternal plasma and serum. (11901066)
2002
38
Partial HELLP Syndrome: maternal and perinatal outcome. (12563425)
2002
39
Plasma exchange in severe postpartum HELLP syndrome. (12190795)
2002
40
Incidence of the factor V Leiden-mutation, coagulation inhibitor deficiency, and elevated antiphospholipid-antibodies in patients with preeclampsia or HELLP-syndrome. Hemolysis, elevated liver-enzymes, low platelets. (11187029)
2000
41
Effect of corticosteroids on HELLP syndrome: a case report. (11155438)
2000
42
A review of HELLP syndrome. (10642976)
1999
43
Absence of seasonal variation on the frequency of HELLP syndrome. (9715217)
1998
44
Elevated serum levels of the c-erbB-2 encoded oncoprotein fragment in cases of pure preeclampsia and HELLP syndrome. (9158311)
1997
45
Extensive reversible brain magnetic resonance lesions in a patient with HELLP syndrome. (9344010)
1997
46
Induction of HELLP syndrome-like biochemical parameters by stimulation of the celiac ganglion in rats. (8761894)
1996
47
D-dimer test for early detection of HELLP syndrome. (7716593)
1995
48
HELLP syndrome. Managing a pregnancy complication. (7566720)
1995
49
Thrombelastography reveals two causes of haemorrhage in HELLP syndrome. (7537514)
1995
50
Haptoglobin as a sensitive marker of hemolysis in HELLP-syndrome. (1358701)
1992

Genetic Variations for Hellp Syndrome

About this section

Expression for genes affiliated with Hellp Syndrome

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hellp Syndrome

Search GEO for disease gene expression data for Hellp Syndrome.

Pathways for genes affiliated with Hellp Syndrome

About this section
Sources:
53Reactome, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems
See all sources

Pathways related to Hellp Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3SERPINE1, VWF, F5
2
Hide members
10.3F5, VWF, SERPINE1, SERPINC1
3
Hide members
10.3SERPINC1, SERPINE1, VWF, F5

Compounds for genes affiliated with Hellp Syndrome

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 2BitterDB, 28IUPHAR, 59Tocris Bioscience
See all sources

Compounds related to Hellp Syndrome according to GeneCards/GeneDecks:

(show top 50)    (show all 178)
idCompoundScoreTop Affiliating Genes
1estrogen4410.8APOH, AHSP
2warfarin44 49 11 2413.7SERPINC1, VWF, APOH
3aspartate4410.6GPT, SLC17A5, OTC, BCHE, EPHX2
4acetaminophen44 2 49 11 2414.6GPT, EPHX2, SLC17A5
5heparin44 28 11 2413.6APOH, ADAMTS13, MTHFR, AHSP, HP, BCHE
6desmopressin44 59 28 1113.6ADAMTS13, SERPINC1, F5, VWF, SERPINE1
7ristocetin4410.6F5, SERPINC1, ADAMTS13, VWF
8ticlopidine44 1111.6VWF, APOH, SERPINC1, ADAMTS13
9kininogen4410.6SERPINE1, SERPINC1, F5, VWF, HP, APOH
10malondialdehyde4410.6F5, HP, GPT, SLC17A5, APOH
11valproate4410.6SLC17A5, MTHFR, GPT, OTC, EPHX2
12serine4410.6HADHA, EPHX2, HP, ADAMTS13, BCHE
13vitamin b124410.6SLC17A5, VWF, F5, MTHFR, HP, GPT
14urea44 11 2412.6OTC, EPHX2, HP, SLC17A5, GPT, F5
15uric acid44 2411.6APOH, HP, GPT, SLC17A5, SERPINE1, F5
16metformin44 49 1112.6GPT, SLC17A5, MTHFR, SERPINE1, VWF, F5
17glutamate4410.6APOH, HADHA, EPHX2, AHSP, GPT, OTC
18pge14410.5BCHE, F5, APOH, VWF, SERPINE1, SLC17A5
19endotoxin4410.5ADAMTS13, SERPINE1, HP, AHSP, F5, APOH
20folate4410.5GSTP1, APOH, F5, MTHFR, HP, SLC17A5
21simvastatin44 49 59 28 11 2415.5BCHE, VWF, GPT, SLC17A5, F5, SERPINE1
22aprotinin44 1111.5VWF, SLC17A5, SERPINC1, F5, SERPINE1
23prostacyclin4410.5HADHA, F5, SERPINE1, APOH, SERPINC1, VWF
24homocysteine44 2411.5HP, AHSP, F5, APOH, MTHFR, SERPINC1
25polyethylene glycol4410.5SERPINC1, BCHE, F5, SLC17A5, HP
26nicotine44 49 28 1113.5AHSP, SERPINE1, SERPINC1, GPT, BCHE, VWF
27ascorbic acid44 2411.5GSTP1, VWF, HP, F5, SERPINC1, MTHFR
28cyclophosphamide44 49 1112.5MTHFR, SERPINE1, BCHE, ADAMTS13, APOH, GSTP1
29glucose4410.5BCHE, AHSP, OTC, BNIP3, APOH, HADHA
30valproic acid44 49 11 2413.4EPHX2, GPT, SLC17A5, OTC, MTHFR
31methotrexate44 49 1112.4MTHFR, SLC17A5, GPT, SERPINE1, GSTP1, APOH
32sodium dodecylsulfate4410.4F5, HP, VWF, GSTP1, SERPINE1
33testosterone44 59 11 2413.4SERPINE1, SLC17A5, GSTP1, F5, VWF, HP
34arachidonic acid44 28 11 2413.4HADHA, HP, VWF, AHSP, EPHX2, LGALS13
35fibrinogen4410.4MTHFR, APOH, F5, ADAMTS13, SERPINC1, SERPINE1
36alanine4410.4HP, VWF, GPT, F5, GSTP1, SLC17A5
37cholesterol44 28 11 2413.4AHSP, SERPINE1, F5, APOH, SLC17A5, MTHFR
38lactate4410.4BCHE, BNIP3, APOH, HADHA, F5, HP
39aspirin44 49 28 2413.4SERPINC1, BCHE, GSTP1, SERPINE1, VWF, HADHA
40glutamine4410.4OTC, EPHX2, SLC17A5, GPT, VWF, HADHA
41hepaplastin4410.3GPT, SLC17A5, SERPINC1
42arginine4410.3BCHE, SERPINC1, OTC, GPT, GSTP1, F5
43ancrod4410.3SERPINC1, SERPINE1, F5
44atorvastatin44 49 28 11 2414.3SERPINE1, F5, VWF, GPT, SLC17A5
45nitric oxide44 11 2412.3BNIP3, SERPINE1, APOH, VWF, OTC, SLC17A5
46p0024410.3HP, APOH, F5, GPT, MTHFR
47creatinine4410.2SLC17A5, APOH, HADHA, F5, MTHFR, HP
48vegf4410.2SERPINE1, HP, SERPINC1, F5, GSTP1, APOH
49hirudin4410.2F5, SERPINC1, SERPINE1, VWF
50ximelagatran44 1111.0SERPINC1, GPT, F5

GO Terms for genes affiliated with Hellp Syndrome

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Hellp Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:03109310.3SERPINE1, VWF, F5
2extracellular spaceGO:0056159.8ADAMTS13, APOH, F5, HP, SERPINE1, SERPINC1

Biological processes related to Hellp Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of fibrinolysisGO:05191810.4SERPINE1, APOH
2negative regulation of blood coagulationGO:03019510.4SERPINE1, APOH
3platelet activationGO:03016810.3ADAMTS13, SERPINE1, VWF, F5
4platelet degranulationGO:00257610.2F5, VWF, SERPINE1
5positive regulation of blood coagulationGO:03019410.1SERPINE1, APOH

Molecular functions related to Hellp Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00202010.3SERPINC1, SERPINE1, VWF
2hemoglobin bindingGO:03049210.1HP, AHSP

Products for genes affiliated with Hellp Syndrome

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hellp Syndrome

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet