Helminthiasis malady

Wikipedia: Helminthiasis is a macroparasitic disease of humans and animals in which a part of the body is infected...⁴⁴ more...

MalaCards: Helminthiasis, also known as intestinal helminthiasis, is related to anisakiasis and toxocariasis. An important gene associated with Helminthiasis is RNASE3 (ribonuclease, RNase A family, 3), and among its related pathways are IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types and Fc epsilon RI signaling pathway. The drug niclosamide and the compounds vegf and mometasone furoate have been mentioned in the context of this disorder. Affiliated tissues include liver.

helminthiasis 30 32 43 intestinal helminthiasis 30

worm infections 30

Diseases related to helminthiasis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 178)

id	Related Disease	Score	Top Affiliating Genes
1	anisakiasis	26.8	RNASE3, IGHE
2	toxocariasis	26.8	RNASE3, IGHE
3	strongyloidiasis	26.8	IGHE, IL5
4	echinococcosis	26.6	IL5, IGHE
5	angiostrongyliasis	26.5	IL5, IL13
6	asthma	26.5	RNASE3, IGHE, IL5, IL13
7	trichuriasis	26.4	RNASE3, IL13
8	paragonimiasis	26.1	RNASE3, IGHE, IL5
9	ascariasis	26.1	RNASE3, IGHE, IL5
10	filariasis	25.6	IGHE, IL5, IL13
11	schistosomiasis	24.9	RNASE3, IGHE, IL5, IL13
12	giant papillary conjunctivitis	12.9	IL5, RNASE3
13	chronic eosinophilic pneumonia	12.9	RNASE3, IL5
14	status asthmaticus	12.9	IL5, RNASE3
15	ocular cicatricial pemphigoid	12.9	IL5, RNASE3
16	common cold	12.9	RNASE3, IL5
17	b cell deficiency	12.8	IL5, IGHE
18	pthirus pubis infestation	12.8	IL5, IGHE
19	contact dermatitis	12.8	IL5, IGHE
20	egg allergy	12.8	IGHE, IL5
21	allergic bronchopulmonary aspergillosis	12.8	IGHE, IL5
22	arteriovenous malformation	12.8	RNASE3, IL5
23	omenn syndrome	12.8	IGHE, IL5
24	hypergammaglobulinemia	12.8	IL5, IGHE
25	obstructive lung disease	12.8	IGHE, RNASE3
26	pulmonary alveolar proteinosis	12.7	IGHE, IL5
27	fasciitis	12.7	IL5, IGHE
28	autoimmune hemolytic anemia	12.7	IL5, IGHE
29	intestinal schistosomiasis	12.7	IL13, IL5
30	bronchiectasis	12.6	RNASE3, IGHE
31	respiratory syncytial virus infectious disease	12.6	IL5, IL13
32	cutaneous leishmaniasis	12.6	IL5, IL13
33	panbronchiolitis	12.5	IL5, IL13
34	diffuse panbronchiolitis	12.5	IL5, IL13
35	dermatitis herpetiformis	12.5	IL13, IL5
36	rubella	12.5	IL5, IGHE
37	chronic fatigue syndrome	12.5	IGHE, RNASE3
38	retinopathy of prematurity	12.5	IL13, IL5
39	bronchiolitis obliterans	12.5	IL13, RNASE3
40	osteomyelitis	12.5	IL13, RNASE3
41	biliary tract cancer	12.4	IL5, IL13
42	cough variant asthma	12.4	RNASE3, IGHE, IL5
43	intrinsic asthma	12.4	RNASE3, IGHE, IL5
44	eosinophilic gastroenteritis	12.4	RNASE3, IGHE, IL5
45	peripheral t-cell lymphoma	12.4	IL5, IL13
46	bronchitis	12.4	RNASE3, IGHE, IL5
47	cicatricial pemphigoid	12.3	IL5, IGHE, RNASE3
48	angioedema	12.3	RNASE3, IGHE, IL5
49	t cell deficiency	12.3	IGHE, IL5
50	pemphigus vulgaris	12.3	RNASE3, IGHE, IL5

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 niclosamide

MalaCards organs/tissues related to helminthiasis:

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Genes related to helminthiasis according to GeneCards:

id	Symbol	Description	Score	GeneCards Section Context
1	RNASE3	ribonuclease, RNase A family, 3	11.0
2	IGHE	immunoglobulin heavy constant epsilon	11.0
3	IL13	interleukin 13	11.0
4	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0

Pathways related to helminthiasis according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.1	IL13, IL5
2	Fc epsilon RI signaling pathway20	9.1	IL5, IL13
3	OX40 Pathway36	9.0	IL5, IL13
4	Cytokine Network36	8.8	IL13, IL5
5	Asthma20	8.7	IL5, RNASE3, IL13

Compounds related to helminthiasis according to GeneDecks:

(show top 50)    (show all 84)

id	Compound	Score	Top Affiliating Genes
1	vegf32	10.2	RNASE3
2	mometasone furoate32	9.7	IL5, RNASE3
3	levocabastine32 9 9	11.7	RNASE3, IL5
4	oxatomide32	9.6	IL5, IGHE
5	lte432	9.6	RNASE3, IL5
6	tele-methylhistamine32	9.6	IGHE, RNASE3
7	anti-histamine32	9.5	IGHE, RNASE3
8	pranlukast32 9 9	11.4	RNASE3, IL5
9	trimellitic anhydride32	9.4	IGHE, IL13
10	methyltetrahydrophthalic anhydride32	9.4	IL13, IGHE
11	unicap32	9.2	IL5, IGHE, RNASE3
12	beclomethasone dipropionate32	9.2	IL5, IGHE, RNASE3
13	sodium cromoglycate32	9.2	RNASE3, IGHE, IL5
14	toluene diisocyanate32	9.2	IL5, IGHE, RNASE3
15	nedocromil sodium32	9.2	IL5, RNASE3, IGHE
16	cetirizine32 9 18 9	12.2	IL5, IGHE, RNASE3
17	ketotifen32 9 9	11.2	RNASE3, IL5, IGHE
18	azelastine32 9 9	11.2	RNASE3, IL5, IGHE
19	capsaicin32	9.2	RNASE3, IL5, IGHE
20	loratadine32 9 18 9	12.0	RNASE3, IGHE
21	formoterol32 9 9	11.0	RNASE3, IL13
22	desloratadine32 34 9 9	12.0	IGHE, IL13
23	salmeterol32 42 9 9	12.0	RNASE3, IL5, IL13
24	ltd432	9.0	IL13, RNASE3, IL5
25	ltc432	9.0	IL5, RNASE3, IL13
26	theophylline32 9 18 9	12.0	IL13, IL5, RNASE3
27	omalizumab32 9 9	10.9	IGHE, IL5, IL13
28	ovomucoid32	8.9	IL13, IL5, IGHE
29	leukotriene b432 42 18	10.9	IL5, RNASE3, IL13
30	penicillin32	8.9	IL5, IGHE, IL13
31	tarc32	8.9	IGHE, IL13, IL5
32	hydrocortisone32 9 9	10.8	IGHE, IL5, IL13
33	thyroxine32 18	9.7	IL13, IGHE, IL5
34	fmlp32	8.7	IL13, IL5, RNASE3
35	isoproterenol32 9 9	10.6	IL5, IGHE, IL13
36	praziquantel32 9 9	10.4	IL13, IL5, IGHE, RNASE3
37	montelukast32 34 9 9	11.4	RNASE3, IGHE, IL13, IL5
38	budesonide32 42 9 9	11.4	RNASE3, IL13, IGHE, IL5
39	salbutamol32 34 9 18 9	12.4	IL13, IGHE, RNASE3, IL5
40	fluticasone propionate32 42 9 9	11.4	IGHE, RNASE3, IL5, IL13
41	pgd232	8.4	IL5, IGHE, RNASE3, IL13
42	methacholine32 9 9	10.4	IL13, IL5, IGHE, RNASE3
43	allergens32	8.4	RNASE3, IGHE, IL5, IL13
44	prednisolone32 9 9	10.4	IL13, IL5, IGHE, RNASE3
45	histamine32 18	9.4	IGHE, IL5, RNASE3, IL13
46	cyclosporin a32 42	9.3	IL13, IL5, IGHE, RNASE3
47	heparin32 9 18 9	11.3	RNASE3, IL5, IL13, IGHE
48	adenylate32	8.3	IL5, IL13, RNASE3, IGHE
49	dexamethasone32 42 34 9 9	12.3	IL13, IL5, IGHE, RNASE3
50	arginine32	8.2	IL5, IL13, RNASE3, IGHE

Biological processes related to helminthiasis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of B cell proliferation	GO:030890	8.8	IL13, IL5
2	immune response	GO:006955	8.5	IL13, IL5, IGHE