Hemangioblastoma malady

NIH Rare Diseases: A hemangioblastoma is a benign, highly vascular tumor that can occur in the brain, spinal cord, and retina (the light-sensitive tissue that lines the back of the eye). This tumor accounts for about 2% of brain tumors. As it enlarges, it presses on the brain and can cause neurological symptoms, such as headaches, weakness, sensory loss, balance and coordination problems, and/or hydrocephalus (a buildup of spinal fluid in the brain). Most hemangioblastomas occur sporadically. However, some people develop hemangioblastomas as part of a genetic syndrome called von Hippel-Lindau syndrome. These people usually develop multiple tumors within the brain and spinal cord over their lifetime.³⁰

MalaCards: Hemangioblastoma, also known as capillary hemangioblastoma, is related to central nervous system hemangioblastoma and retinal hemangioblastoma. An important gene associated with Hemangioblastoma is VHL (von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase), and among its related pathways are Actin-Based Motility by Rho Family GTPases and Renal cell carcinoma. The compounds s 100 and reticulin have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and retina, and related mouse phenotypes are respiratory system and hematopoietic system.

Wikipedia: Hemangioblastomas (capilliary hemangioblastomas) are tumors of the central nervous system that originate...⁴⁴ more...

Aliases & Descriptions:

hemangioblastoma 6 7 30 32 43 capillary hemangioblastoma 6 30

hemangioblastoma (morphologic abnormality) 6

Diseases related to hemangioblastoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 658)

id	Related Disease	Score	Top Affiliating Genes
1	central nervous system hemangioblastoma	32.2	VHL, MUC1, ANGPT4, DIRC2, PLAGL1
2	retinal hemangioblastoma	31.5	VEGFA, CD2, CXCL12, CXCR4
3	von hippel-lindau disease	30.0	VIM, VHL, VEGFA, MUC1, INHA, CCND1
4	erythrocytosis	27.8	VHL, HIF1A, TIMP1, EPO, EPOR
5	polycythemia	26.9	VHL, VEGFA, CD34, HBA1, HIF1A, TIMP1
6	myxoma	26.8	VIM, VEGFA, MUC1, S100A1, S100B, FLT1
7	clear cell renal cell carcinoma	26.8	VIM, VHL, VEGFA, KDR, MUC1, MME
8	renal cell carcinoma	26.7	VIM, VHL, VEGFA, KDR, MUC1, S100A1
9	hemangiopericytoma	26.2	NCAM1, VIM, VEGFA, KDR, MUC1, S100A1
10	glioblastoma	25.6	VHL, VEGFA, KDR, FLT1, TP53, EGFR
11	retinitis	19.9	VTN, SELE, VIM, VHL, VEGFA, VCAM1
12	meningioma	17.8	NCAM1, SELE, VIM, VHL, VEGFA, VCAM1
13	cerebritis	17.6	NCAM1, VTN, SELE, VIM, VHL, VEGFA
14	carcinoma	17.4	NCAM1, VTN, SELE, VIM, VHL, VEGFA
15	acoustic neuroma	13.8	VHL, EZR, EPOR
16	intraneural perineurioma	13.8	MUC1, S100B, SLC2A1
17	primary polycythemia	13.8	VHL, EPO, EPOR
18	anaplastic ependymoma	13.8	MUC1, S100B, GFAP
19	anaplastic ganglioglioma	13.8	S100B, GFAP, NES
20	cerebral neuroblastoma	13.7	ENO2, GFAP
21	myxopapillary ependymoma	13.7	S100B, GFAP
22	central neurocytoma	13.7	GFAP, SYP, NES
23	gliofibroma	13.7	S100B, GFAP
24	papillary ependymoma	13.7	S100B, GFAP, SYP
25	pineal gland cancer	13.7	ENO2, GFAP, SYP
26	choroid plexus papilloma	13.7	MUC1, S100B, GFAP, SYP
27	esthesioneuroblastoma	13.7	S100B, ENO2, SYP
28	follicular dendritic cell tumor	13.7	S100B, PDPN, CXCL12
29	endolymphatic sac tumor	13.7	VHL, HIF1A, EPO, EPOR
30	hemangioma of liver	13.7	VEGFA, DES
31	spindle cell thymoma	13.7	MUC1, DES
32	fibrous meningioma	13.6	MUC1, S100B, DES
33	pineocytoma	13.6	S100B, ENO2, GFAP, SYP
34	periventricular leukomalacia	13.6	VEGFA, NES, EPO
35	pulmonary sclerosing hemangioma	13.6	MUC1, ENO2, SYP
36	leukomalacia	13.6	VEGFA, NES, EPO
37	retinal ischemia	13.6	VEGFA, HIF1A, GFAP, CXCL12
38	psammomatous meningioma	13.6	MUC1, GFAP
39	intraocular melanoma	13.6	S100B, EZR, KRT8, CXCR4
40	periostitis	13.6	VEGFA, KDR, MUC1, FLT1
41	orbital lymphangioma	13.6	FLT4, PDPN
42	corneal neovascularization	13.6	VEGFA, KDR, FLT1, CXCL12
43	cerebral hemorrhage	13.6	S100B, ENO2, GFAP, SYP
44	acute mountain sickness	13.6	VHL, VEGFA, FLT1, ENO2, HIF1A
45	neurofibromatosis	13.6	VHL, BLZF1, S100B, ENO2
46	creutzfeldt-jakob syndrome	13.6	S100B, ENO2, NES
47	peripheral neuroblastoma	13.6	S100B, SYP
48	clear cell ependymoma	13.6	VIM, MUC1
49	hemangioma, capillary infantile, somatic	13.6	KDR, FLT4
50	prostate stromal sarcoma	13.6	VIM, MUC1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to hemangioblastoma:

²²

MGI Mouse Phenotypes related to hemangioblastoma:

²⁵ (show all 21)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.2	PGF, TIE1, PLAGL1, ICAM2
2	hematopoietic system phenotype	MP:0005397	9.1	EPOR, EPO, KRT8, ICAM2, CCND1, AQP1
3	liver/biliary system phenotype	MP:0005370	8.9	EPO, HIF1A, EGFR, TP53, VEGFA, VHL
4	reproductive system phenotype	MP:0005389	8.8	TIMP1, HBA1, KRT8, CCND1, INHA, FLT1
5	embryogenesis phenotype	MP:0005380	8.5	EPOR, WNT2, CXCR4, TIE1, EGFR, KRT8
6	normal phenotype	MP:0002873	8.4	INHA, HIF1A, GFAP, SYP, EPO, EPOR
7	behavior/neurological phenotype	MP:0005386	7.7	PROM1, DES, GFAP, PDPN, ENO2, AQP1
8	no phenotypic analysis	MP:0003012	7.5	EPOR, SLC2A1, PROM1, SYP, EGFR, PLAGL1
9	nervous system phenotype	MP:0003631	7.5	PROM1, CXCL12, CXCR4, SLC2A1, NES, EPOR
10	skeleton phenotype	MP:0005390	7.3	PDPN, EGFR, HIF1A, TGFA, CXCR4, PLAGL1
11	integument phenotype	MP:0010771	7.2	PLAGL1, PDPN, EGFR, TIE1, TGFA, TP53
12	digestive/alimentary phenotype	MP:0005381	6.9	EGFR, HIF1A, GFAP, TIE1, TGFA, CXCR4
13	muscle phenotype	MP:0005369	6.8	HIF1A, GFAP, TIE1, TGFA, DES, CXCR4
14	tumorigenesis	MP:0002006	6.6	HIF1A, TIMP1, PROM1, PGF, EGFR, TP53
15	immune system phenotype	MP:0005387	6.6	KRT8, EGFR, GFAP, TIE1, PGF, PECAM1
16	vision/eye phenotype	MP:0005391	6.1	TP53, EGFR, HIF1A, GFAP, TGFA, PROM1
17	growth/size phenotype	MP:0005378	6.0	EGFR, HIF1A, GFAP, TIE1, TGFA, PROM1
18	mortality/aging	MP:0010768	5.4	PDPN, KRT8, EGFR, HBA1, GFAP, TIE1
19	cellular phenotype	MP:0005384	4.6	HIF1A, GFAP, TIE1, PROM1, CXCL12, CXCR4
20	cardiovascular system phenotype	MP:0005385	3.6	SELE, HIF1A, GFAP, TIE1, TIMP1, TGFA
21	homeostasis/metabolism phenotype	MP:0005376	3.6	TIMP1, TIE1, GFAP, HIF1A, EGFR, PDPN

Articles related to hemangioblastoma:

(show top 50)    (show all 55)

id	Title	Authors	Year	Affiliating Genes
1	Spinal hemangioblastoma. (21685785)	Pruksakorn P.... Snabboon T.	2011	VHL
2	Overexpression and activation of epidermal growth fac tor receptor in hemangioblastomas. (20730556)	Chen G.J.... Zagzag D.	2010	EGFR
3	Clinicopathologic study of von Hippel-Lindau syndrom e-related and sporadic hemangioblastomas of central nervous system (20450758)	Zhou J.... Zhang R.S.	2010	INHA
4	Low frequency of VHL germline mutations in Norwegian patients presenting with isolated central nervous system hemangioblastomas--a p opulation-based study. (19814753)	RA... Helseth E.	2010	VHL
5	Molecularly genetic analysis of von Hippel-Lindau ass ociated central nervous system hemangioblastoma. (20518900)	Zhou J.... Zhou X.	2010	PLAGL1
6	A vitronectin M381T polymorphism increases risk of hemangioblastoma in patients with VHL gene defect. (19288063)	Huang J.S.... Huang C.J.	2009	VHL, VTN
7	Immunohistochemical markers to distinguish between hemangioblastoma and metastatic clear-cell renal cell carcinoma in the brain: utility of aquaporin1 combined with cytokeratin AE1/AE3 immunostaining. (18496143)	Weinbreck N.... Vignaud J.M.	2008	MUC1, INHA
8	Atrial myxoma occurring 15 years after subtotal resection of cerebellar hemangioblastoma. (18219192)	Yanagawa Y.... Maehara T.	2008	VEGFA
9	Internal en bloc resection and genetic analysis of retinal capillary hemangioblastoma. (17846357)	Schlesinger T.... Wilson D.J.	2007	VHL
10	Molecular pathology and CXCR4 expression in surgically excised retinal hemangioblastomas associated with von Hippel-Lindau disease. (17070589)	Liang X.... Chan C.C.	2007	CXCR4, VEGFA, CXCL12
11	Preferential loss of the nonimprinted allele for the ZAC1 tumor suppressor gene in human capillary hemangioblastoma. (17805016)	Lemeta S.... Husgafvel-Pursiainen K.	2007	PLAGL1
12	Aquaporin 1 expression in cystic hemangioblastomas. (16300893)	Longatti P.... Martinuzzi A.	2006	AQP1
13	Increased expression of aquaporin 1 in human hemangioblastomas and its correlation with cyst formation. (17077939)	Chen Y.... Takahashi J.A.	2006	AQP1
14	Absence of tight junctions between microvascular endothelial cells in human cerebellar hemangioblastomas. (16955048)	Chen Y.... Takahashi J.A.	2006	VEGFA
15	Cyclin D1 genotype and expression in sporadic hemangioblastomas. (16187023)	Gijtenbeek J.M.... Jeuken J.W.	2005	CCND1
16	Immunoreactivity of CD10 and inhibin alpha in differentiating hemangioblastoma of central nervous system from metastatic clear cell renal cell carcinoma. (15578072)	Jung S.M.... Kuo T.T.	2005	MME, INHA
17	Primary capillary hemangioblastoma of peripheral soft tissues. (15223969)	Michal M.... Koudepa K.	2004	ENO2, DES, CD34
18	Congenital cystic hemangioblastomas of the cerebral hemisphere in a neonate without alteration in the VHL gene. (15367802)	Johnson M.D.... Weil R.J.	2004	VHL
19	Long-term prognosis of hemangioblastomas of the central nervous system: clinical and immunohistochemical study in relation to recurrence. (15700837)	Miyagami M.... Katayama Y.	2004	VEGFA
20	Inhibin alpha distinguishes hemangioblastoma from clear cell renal cell carcinoma. (12883249)	Hoang M.P.... Amirkhan R.H.	2003	INHA
21	Incidence of von Hippel-Lindau disease in hemangioblastoma patients: the University of Tokyo Hospital experience from 1954-1998. (11685621)	Sora S.... Kirino T.	2001	VHL
22	Reconsideration of biallelic inactivation of the VHL tumour suppressor gene in hemangioblastomas of the central nervous system. (11309459)	Glasker S.... Neumann H.P.	2001	VHL
23	Transthyretin and transferrin in hemangioblastoma stromal cells. (11087054)	Bleistein M.... Schlote W.	2000	S100B, ENO2, KRT8
24	Retroperitoneal peripheral hemangioblastoma: a case report and review of the literature. (10760321)	Fanburg-Smith J.C.... Thompson L.D.	2000	S100B, VIM, DES
25	Clinicopathological study of vascular endothelial growth factor (VEGF), p53, and proliferative potential in familial von Hippel-Lindau disease and sporadic hemangioblastomas. (11310918)	Miyagami M.... Nakamura S.	2000	TP53, VEGFA
26	GLUT1 immunoreaction patterns reliably distinguish hemangioblastoma from metastatic renal cell carcinoma. (14606586)	North P.E.... Mrak R.E.	2000	SLC2A1
27	Vascular permeability factor expression in cerebellar hemangioblastomas: correlation with tumor-associated cysts. (10222417)	Vaquero J.... Salas C.	1999	VEGFA
28	The occurrence of cerebellar hemangioblastoma in numerous first degree relatives with von Hippel-Lindau disease. (10581854)	Wysocka B.... Limon J.	1999	VHL
29	Germline mutation profile of the VHL gene in von Hippel-Lindau disease and in sporadic hemangioblastoma. (9829912)	Olschwang S.... Thomas G.	1998	VHL
30	Loss of heterozygosity and somatic mutations of the VHL tumor suppressor gene in sporadic cerebellar hemangioblastomas. (9458097)	Lee J.Y.... Zhuang Z.	1998	VHL
31	Expression of vascular endothelial growth factor in cerebellar hemangioblastomas does not correlate with tumor angiogenesis. (10397476)	Vaquero J.... Oya S.	1998	VEGFA
32	Up-regulation of vascular endothelial growth factor in stromal cells of hemangioblastomas is correlated with up-regulation of the transcription factor HRF/HIF-2alpha. (9665461)	Flamme I.... Plate K.H.	1998	VEGFA
33	Putative control of angiogenesis in hemangioblastomas by the von Hippel-Lindau tumor suppressor gene. (9370235)	Stratmann R.... Plate K.H.	1997	VEGFA, VHL
34	Human telomerase RNA expression and MIB-1 (Ki-67) proliferation index distinguish hemangioblastomas from metastatic renal cell carcinomas. (9413283)	Brown D.F.... Rushing E.J.	1997	MUC1
35	Pathology, genetics and cell biology of hemangioblastomas. (8930647)	Wizigmann-Voos S.... Plate K.H.	1996	FLT1, KDR, VEGFA
36	Differential expression in glioblastoma multiforme and cerebral hemangioblastoma of cytoplasmic proteins that bind two different domains within the 3'-untranslated region of the human glucose transporter 1 (GLUT1) messenger RNA. (8675694)	Tsukamoto H.... Pardridge W.M.	1996	SLC2A1, BLZF1
37	Vascular growth factors and receptors in capillary hemangioblastomas and hemangiopericytomas. (8774132)	Hatva E.... Alitalo K.	1996	FLT4, VEGFA, PGF
38	Ezrin expression in stromal cells of capillary hemangioblastoma. An immunohistochemical survey of brain tumors. (8579099)	Bohling T.... Haltia M.	1996	EGFR, EZR
39	Expression of growth factors and growth factor receptors in capillary hemangioblastoma. (8627342)	BAPhling T.... Haltia M.	1996	EGFR, VEGFA, WNT2
40	Different expression of adhesion molecules on stromal cells and endothelial cells of capillary hemangioblastoma. (8922057)	BAPhling T.... Haltia M.	1996	NCAM1, SELE, VCAM1
41	High expression of the Glut1 glucose transporter in human brain hemangioblastoma endothelium. (7595657)	Cornford E.M.... Pardridge W.M.	1995	SLC2A1
42	Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas. (7533661)	Wizigmann-Voos S.... Plate K.H.	1995	VEGFA
43	Coexpression of transforming growth factor-alpha and Acpidermal growth factor receptor in capillary hemangioblastomas of the central nervous system. (7639324)	Reifenberger G.... Collins V.P.	1995	TGFA
44	Immunohistochemical study of basic fibroblast growth factor and erythropoietin in cerebellar hemangioblastomas. (7894620)	Tachibana O.... Takinami K.	1994	EPO
45	Somatic mutations of the von Hippel-Lindau tumor suppressor gene in sporadic central nervous system hemangioblastomas. (8069849)	Kanno H.... Yao M.	1994	VHL
46	Expression of vascular endothelial growth factor in capillary hemangioblastoma. (7688226)	Morii K.... Kuwano R.	1993	VEGFA
47	Immunohistochemical observations on 67 hemangioblastomas (8168195)	Yu S.Z.	1993	S100B, GFAP
48	Monitoring hemangioblastoma tumor burden using plasma erythropoietin levels. (1421181)	Munt B.... Krystal G.	1992	TIMP1
49	Immunohistochemical study of erythropoietin in cerebellar hemangioblastomas associated with secondary polycythemia. (1994278)	Tachibana O.... Yamashita J.	1991	EPO
50	Von Hippel-Lindau disease and erythrocytosis: radioimmunoassay of erythropoietin in cyst fluid from a brainstem hemangioblastoma. (2027498)	Horton J.C.... Hoyt W.F.	1991	EPO

Genes related to hemangioblastoma according to GeneCards:

(show all 49)

id	Symbol	Description	Score	GeneCards Section Context
1	VHL	von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase	11.0	Publications
2	MUC1	mucin 1, cell surface associated	11.0	Publications
3	VEGFA	vascular endothelial growth factor A	11.0	Publications
4	INHA	inhibin, alpha	11.0	Publications
5	PLAGL1	pleiomorphic adenoma gene-like 1	11.0	Publications
6	ANGPT4	angiopoietin 4	11.0
7	AQP1	aquaporin 1 (Colton blood group)	11.0	Publications
8	KRT8	keratin 8	11.0	Publications
9	EZR	ezrin	11.0	Publications
10	PDPN	podoplanin	11.0
11	NES	nestin	11.0
12	EPOR	erythropoietin receptor	11.0	Publications
13	ENO2	enolase 2 (gamma, neuronal)	11.0	Publications
14	S100B	S100 calcium binding protein B	11.0	Publications
15	GFAP	glial fibrillary acidic protein	11.0	Publications
16	SLC2A1	solute carrier family 2 (facilitated glucose transporter), member 1	11.0	Publications
17	SYP	synaptophysin	11.0
18	CXCL12	chemokine (C-X-C motif) ligand 12	11.0	Publications
19	CXCR4	chemokine (C-X-C motif) receptor 4	11.0	Publications
20	EPO	erythropoietin	11.0	Publications
21	KDR	kinase insert domain receptor (a type III receptor tyrosine kinase)	11.0	Publications
22	FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	11.0	Publications
23	TGFA	transforming growth factor, alpha	11.0	Publications
24	HIF1A	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11.0
25	SDHAF2	succinate dehydrogenase complex assembly factor 2	11.0
26	ICAM2	intercellular adhesion molecule 2	11.0	Publications
27	TIE1	tyrosine kinase with immunoglobulin-like and EGF-like domains 1	11.0	Publications
28	WNT2	wingless-type MMTV integration site family member 2	11.0	Publications
29	PGF	placental growth factor	11.0	Publications
30	CD34	CD34 molecule	11.0	Publications
31	DIRC2	disrupted in renal carcinoma 2	11.0
32	HBA1	hemoglobin, alpha 1	11.0	Publications
33	S100A1	S100 calcium binding protein A1	11.0	Publications
34	CD2	CD2 molecule	11.0
35	BLZF1	basic leucine zipper nuclear factor 1	11.0	Publications
36	DES	desmin	11.0	Publications
37	PECAM1	platelet/endothelial cell adhesion molecule 1	11.0	Publications
38	VTN	vitronectin	11.0	Publications
39	FLT4	fms-related tyrosine kinase 4	11.0	Publications
40	PROM1	prominin 1	11.0	Publications
41	VIM	vimentin	11.0	Publications
42	MME	membrane metallo-endopeptidase	11.0	Publications
43	VCAM1	vascular cell adhesion molecule 1	11.0	Publications
44	NCAM1	neural cell adhesion molecule 1	11.0	Publications
45	SELE	selectin E	11.0	Publications
46	TIMP1	TIMP metallopeptidase inhibitor 1	11.0	Publications
47	CCND1	cyclin D1	11.0	Publications
48	EGFR	epidermal growth factor receptor	11.0	Publications
49	TP53	tumor protein p53	11.0	Publications

Pathways related to hemangioblastoma according to GeneDecks:

(show top 50)    (show all 92)

id	Pathway	Score	Top Affiliating Genes
1	Actin-Based Motility by Rho Family GTPases36	10.3	PGF
2	Renal cell carcinoma20	10.2	TGFA, PGF, HIF1A, VHL
3	Breast Cancer Regulation by Stathmin136	9.9	EGFR, TGFA
4	Development VEGF-family signaling10	9.8	KDR, PGF, FLT4, VTN, FLT1, VEGFA
5	Development_VEGF-family signaling41	9.8	VTN, PGF, FLT4, FLT1, KDR, VEGFA
6	14-3-3 Induced Intracellular Signaling36	9.7	EPOR, PGF, TIMP1, FLT1, FLT4
7	Cell adhesion molecules (CAMs)20	9.4	CD2, NCAM1, CD34, ICAM2, PECAM1
8	Rac1 Pathway36	9.3	TIMP1, KDR, FLT4, CXCL12, PGF
9	Angiogenesis3	9.2	FLT4, FLT1, KDR, VHL, TIMP1, HIF1A
10	Akt Signaling36	9.2	EPOR, CD2, FLT4, ANGPT4, CCND1, CXCL12
11	PPAR Pathway36	9.2	CXCL12, FLT4, FLT1, EGFR, PGF
12	JNK Pathway36	9.1	FLT1, FLT4, ANGPT4, CXCL12, PGF, EPOR
13	ERK5 Signaling36	8.9	KDR, TGFA, PGF, CXCL12, FLT4, FLT1
14	Cytokine-cytokine receptor interaction20	8.9	VEGFA, FLT1, EPOR, FLT4, EPO, CXCR4
15	Focal adhesion20	8.8	CCND1, EGFR, FLT1, KDR, VTN
16	eIF2 Pathway36	8.6	TIMP1, FLT4, PGF, CXCL12, TGFA, EGFR
17	eNOS Signaling36	8.6	FLT4, AQP1, TIMP1, TGFA, CXCL12, PGF
18	PTEN Pathway36	8.6	FLT1, FLT4, TP53, PGF, KDR, EGFR
19	NF-KappaB (p50-p65) Pathway36	8.4	PGF, CXCL12, TGFA, TIMP1, EGFR, FLT4
20	DHA Signaling36	8.4	FLT4, CXCL12, TGFA, TIMP1, EGFR, PGF
21	NF-KappaB Family Pathway36	8.4	EGFR, TIMP1, KDR, TGFA, FLT4, CXCL12
22	Pathways in cancer20	8.4	TGFA, HIF1A, VEGFA, CCND1, TP53, EGFR
23	Paxillin Interactions36	8.4	KDR, FLT1, FLT4, TIMP1, EGFR, TGFA
24	Ras Pathway36	8.4	TIMP1, FLT1, FLT4, EGFR, TGFA, KDR
25	NFAT in Immune Response36	8.3	EGFR, FLT1, FLT4, EPOR, PGF, CXCL12
26	Nanog in Mammalian ESC Pluripotency36	8.3	FLT1, KDR, WNT2, FLT4, EPOR, EGFR
27	Nuclear Receptor Activation by Vitamin-A36	8.2	KDR, PGF, CXCL12, TGFA, TIMP1, EGFR
28	TGF-Beta Pathway36	8.2	TIMP1, FLT1, KDR, PGF, CXCL12, TGFA
29	GSK3 Signaling36	8.2	EPOR, WNT2, PGF, CXCL12, FLT1, FLT4
30	ERK Signaling36	8.2	CD2, EGFR, FLT1, FLT4, EPOR, PGF
31	PAK Pathway36	8.2	TGFA, TIMP1, PGF, EGFR, ANGPT4, FLT1
32	MAPK Family Pathway36	8.2	PGF, TGFA, TIMP1, EGFR, CXCL12, ANGPT4
33	GPCR Pathway36	8.2	FLT4, KDR, FLT1, EGFR, TIMP1, TGFA
34	ILK Signaling36	8.1	EPOR, KDR, PGF, FLT4, CXCL12, TGFA
35	IP3 Pathway36	8.1	KDR, FLT4, CXCL12, EGFR, TIMP1, TGFA
36	Renin-Angiotensin Pathway36	8.1	PGF, CXCL12, TGFA, TIMP1, EGFR, FLT4
37	Apoptotic Pathways in Synovial Fibroblasts36	8.0	FLT4, FLT1, KDR, TIMP1, EGFR, TGFA
38	p53 Mediated Apoptosis36	8.0	CXCL12, FLT1, TGFA, TIMP1, FLT4, TP53
39	p70S6K Signaling36	8.0	KDR, FLT1, EGFR, TIMP1, FLT4, PGF
40	Telomerase Components in Cell Signaling36	8.0	TP53, FLT4, PGF, EGFR, TIMP1, TGFA
41	Mitochondrial Apoptosis36	8.0	TGFA, CXCL12, EGFR, TIMP1, TP53, FLT4
42	Cellular Apoptosis Pathway36	8.0	EGFR, FLT1, TIMP1, CXCL12, PGF, KDR
43	Antioxidant Action of Vitamin-C36	8.0	PGF, SLC2A1, FLT1, CD2, ANGPT4, KDR
44	JAK-STAT Pathway36	7.9	CD2, FLT1, FLT4, ANGPT4, EGFR, TIMP1
45	Estrogen Pathway36	7.8	EPOR, PGF, CXCL12, TGFA, TIMP1, EGFR
46	p38 Signaling36	7.5	KDR, PGF, CXCR4, CXCL12, TGFA, TIMP1
47	Rho Family GTPases36	7.5	PGF, VIM, KDR, CD2, FLT1, FLT4
48	Molecular Mechanisms of Cancer36	7.5	KDR, CD2, ANGPT4, CCND1, TP53, EGFR
49	Pancreatic Adenocarcinoma36	7.3	EGFR, FLT4, CCND1, TP53, TIMP1, EPOR
50	MAPK Signaling36	7.2	EPOR, CXCL12, PGF, TIMP1, KDR, FLT1

Compounds related to hemangioblastoma according to GeneDecks:

(show top 50)    (show all 220)

id	Compound	Score	Top Affiliating Genes
1	s 10032	9.7	GFAP, SYP, ENO2, S100B, MUC1, VIM
2	reticulin32	9.6	DES, SYP, GFAP, CD34, S100B, MUC1
3	b 72332	9.5	DES, S100B, SYP, KRT8, PDPN, VIM
4	cobalt chloride32	9.3	SELE, SLC2A1, EPO, VHL, VEGFA, HIF1A
5	agar32	9.1	VIM, MUC1, CD34, CCND1, KRT8, HIF1A
6	oxygen32 18	10.1	BLZF1, FLT1, FLT4, HBA1, HIF1A, GFAP
7	glucose32	9.0	EPOR, NES, PGF, VHL, S100B, CD2
8	sunitinib32 9 9	10.9	HIF1A, VHL, PGF, EGFR, FLT4, VEGFA
9	rapamycin32 42	9.8	VEGFA, KDR, FLT1, FLT4, EGFR, PECAM1
10	arginine32	8.8	DES, TIMP1, GFAP, S100B, BLZF1, VTN
11	ly29400232	8.7	VTN, SELE, VHL, VEGFA, CCND1, TIMP1
12	cysteine32	8.6	S100B, AQP1, KRT8, HIF1A, GFAP, TIMP1
13	heparin32 9 18 9	11.3	NCAM1, VTN, VIM, FLT1, ENO2, TIMP1
14	hematoxylin32	8.3	PECAM1, DES, SYP, GFAP, KRT8, PDPN
15	iron32 18	9.3	ENO2, GFAP, WNT2, VHL, BLZF1, S100A1
16	bromodeoxyuridine32	8.2	ENO2, NCAM1, VIM, NES, S100B, MME
17	ribonucleic acid32	8.1	BLZF1, MUC1, MME, FLT1, INHA, ENO2
18	formaldehyde32 18	9.0	DES, SYP, CCND1, TGFA, PECAM1, MUC1
19	wortmannin32 42	8.8	VTN, VIM, CCND1, EZR, EPOR, PGF
20	glycogen32 18	8.8	KRT8, WNT2, SLC2A1, DES, VIM, VHL
21	creatinine32	7.7	AQP1, GFAP, PGF, FLT1, ENO2, KRT8
22	prostacyclin32	7.7	VCAM1, SELE, VTN, PECAM1, PGF, TGFA
23	butyrate32	7.6	TGFA, KRT8, CXCR4, SLC2A1, EPO, TIMP1
24	glutamate32	7.5	ICAM2, MME, KDR, BLZF1, NCAM1, VTN
25	alanine32	7.4	SLC2A1, CXCR4, GFAP, HIF1A, TGFA, EZR
26	progesterone32 42 9 18 9	11.3	NCAM1, S100A1, S100B, CD34, MME, FLT1
27	thymidine32 18	8.2	ENO2, CCND1, TP53, HIF1A, GFAP, TGFA
28	estrogen32	7.1	KDR, S100A1, S100B, CD34, FLT4, INHA
29	dexamethasone32 42 34 9 9	11.1	NCAM1, VTN, HIF1A, ENO2, AQP1, FLT4
30	actinomycin d32	6.9	EPOR, DES, TGFA, TIMP1, HIF1A, KRT8
31	pd 98,05932	6.8	CCND1, ENO2, VCAM1, VTN, HIF1A, TIMP1
32	adenylate32	6.7	CCND1, ENO2, MME, S100B, VCAM1, VIM
33	paclitaxel32 34 9 9	9.7	CXCR4, TGFA, TIMP1, GFAP, HIF1A, EGFR
34	tamoxifen32 34 9 9	9.6	CCND1, MUC1, KDR, TP53, VEGFA, VIM
35	lactate32	6.5	DES, NCAM1, VTN, SELE, VIM, TGFA
36	cisplatin32 34 9 9	9.5	EPOR, EPO, SLC2A1, CXCR4, SYP, TIMP1
37	nitric oxide32 9 18 9	9.4	CXCR4, PGF, PECAM1, NES, EPOR, SELE
38	doxorubicin32 34 9 9	9.3	KRT8, EGFR, HIF1A, TGFA, DES, EPOR
39	retinoic acid32 42 18	8.3	S100B, CD34, MME, FLT4, ENO2, CCND1
40	lipid32	6.2	AQP1, ENO2, EZR, KRT8, GFAP, SYP
41	sb 20358032 42	7.2	VIM, VEGFA, VCAM1, FLT1, CCND1, TIMP1
42	genistein32 9 18 9	9.2	SELE, VIM, VEGFA, VCAM1, BLZF1, KDR
43	phosphatidylinositol32	5.8	FLT1, CCND1, EZR, EGFR, HIF1A, TIMP1
44	testosterone32 9 18 9	8.7	NCAM1, SELE, VIM, VCAM1, BLZF1, MUC1
45	cycloheximide32	5.6	VTN, PECAM1, SLC2A1, SELE, VIM, VEGFA
46	matrigel32	5.5	SELE, VIM, VEGFA, VCAM1, KDR, MUC1
47	paraffin32	3.5	VIM, VEGFA, VCAM1, KDR, MUC1, S100A1
48	serine32	3.5	HIF1A, GFAP, TIMP1, TGFA, SYP, DES
49	tyrosine32	2.8	NCAM1, VTN, VHL, VEGFA, BLZF1, ICAM2
50	vegf32	2.5	VHL, VEGFA, VCAM1, KDR, MUC1, S100B

Cellular components related to hemangioblastoma according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	microvillus membrane	GO:031528	9.9	PROM1, PDPN, EZR
2	brush border	GO:005903	9.7	MME, AQP1, PROM1
3	intermediate filament	GO:005882	9.6	NES, DES, GFAP, KRT8, VIM
4	external side of plasma membrane	GO:009897	9.0	CXCR4, CXCL12, CD34, CD2, KDR, VCAM1
5	basolateral plasma membrane	GO:016323	8.9	AQP1, EZR, EGFR, TGFA, SLC2A1
6	integral to plasma membrane	GO:005887	8.2	ICAM2, PDPN, TIE1, PROM1, EPOR, AQP1
7	extracellular region	GO:005576	7.7	ANGPT4, TIMP1, CXCL12, PGF, WNT2, EPO
8	extracellular space	GO:005615	7.3	VTN, EPO, PECAM1, PGF, CXCL12, PROM1
9	plasma membrane	GO:005886	5.2	ICAM2, EZR, PDPN, EGFR, TGFA, PROM1

Biological processes related to hemangioblastoma according to GeneDecks:

(show all 25)

id	Name	GO ID	Score	Top Affiliating Genes
1	hemoglobin biosynthetic process	GO:042541	10.4	INHA, HIF1A, EPO
2	regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:061418	10.3	EPO, HIF1A, VEGFA, VHL
3	cellular response to stress	GO:033554	10.3	VHL, VEGFA, AQP1, HIF1A, EPO
4	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia	GO:061419	10.3	HIF1A, VEGFA
5	cellular response to vascular endothelial growth factor stimulus	GO:035924	10.2	FLT4, FLT1, KDR, VEGFA
6	positive regulation of endothelial cell migration	GO:010595	10.1	VEGFA, KDR, FLT4, ANGPT4
7	positive regulation of vascular endothelial growth factor receptor signaling pathway	GO:030949	10.1	HIF1A, FLT1, VEGFA, VTN
8	glomerular endothelium development	GO:072011	10.1	PECAM1, CD34
9	vascular endothelial growth factor receptor signaling pathway	GO:048010	10.0	PGF, FLT4, FLT1, KDR, VEGFA
10	positive regulation of angiogenesis	GO:045766	10.0	HIF1A, ANGPT4, AQP1, FLT1, CD34, KDR
11	Bergmann glial cell differentiation	GO:060020	9.9	GFAP, VIM
12	endothelium development	GO:003158	9.9	CD34, KDR
13	angiogenesis	GO:001525	9.8	PGF, TGFA, TIE1, HIF1A, ANGPT4, KDR
14	positive regulation of endothelial cell proliferation	GO:001938	9.7	WNT2, PGF, CXCL12, HIF1A, FLT4, KDR
15	cellular response to hypoxia	GO:071456	9.7	EPO, HIF1A, TP53, ANGPT4, AQP1, VEGFA
16	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.7	TP53, ANGPT4, VEGFA, VTN
17	response to hypoxia	GO:001666	9.6	PGF, CXCR4, CXCL12, HIF1A, FLT1, VCAM1
18	leukocyte cell-cell adhesion	GO:007159	9.6	SELE, VCAM1, EZR
19	positive regulation of cell migration	GO:030335	9.4	EGFR, PDPN, FLT1, KDR, VEGFA
20	response to drug	GO:042493	9.3	NES, PGF, TGFA, CCND1, ENO2, AQP1
21	cell-cell adhesion	GO:016337	9.2	EGFR, PDPN, ICAM2, CD34, CD2
22	cell proliferation	GO:008283	8.5	TGFA, EGFR, PDPN, TP53, CD34, S100B
23	signal transduction	GO:007165	8.4	EPOR, EPO, PECAM1, PGF, CXCL12, TIE1
24	positive regulation of cell proliferation	GO:008284	8.3	EPO, WNT2, PGF, TIMP1, EGFR, FLT4
25	negative regulation of apoptotic process	GO:043066	8.0	VEGFA, EPO, NES, CXCL12, TIMP1, EGFR

Molecular functions related to hemangioblastoma according to GeneDecks:

(show all 8)

id	Name	GO ID	Score	Top Affiliating Genes
1	vascular endothelial growth factor-activated receptor activity	GO:005021	9.9	KDR, FLT1, FLT4
2	growth factor activity	GO:008083	9.9	VEGFA, INHA, TGFA, CXCL12, PGF
3	integrin binding	GO:005178	9.5	GFAP, ICAM2, KDR, VCAM1, VTN
4	transmembrane receptor protein tyrosine kinase activity	GO:004714	9.1	TIE1, EGFR, FLT4, FLT1, KDR
5	protein heterodimerization activity	GO:046982	8.4	PGF, HIF1A, EGFR, TP53, ENO2, INHA
6	identical protein binding	GO:042802	8.1	EPOR, SLC2A1, SYP, EGFR, TP53, FLT1
7	enzyme binding	GO:019899	7.8	HIF1A, EGFR, TP53, CCND1, BLZF1, VHL
8	protein binding	GO:005515	3.6	SELE, TP53, KRT8, EGFR, HIF1A, TIE1