MCID: HMN016
MIFTS: 45

Hemangioendothelioma malady

Rare diseases category

Summaries for Hemangioendothelioma

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NIH Rare Diseases:43 The term hemangioendothelioma describes several types of vascular neosplasms and includes both non-cancerous (benign) and cancerous (malignant) growths. the term has also been applied to those that show "borderline" behavior, intermediate between entirely benign hemangiomas and highly malignant angiosarcomas. hemangioendotheliomas are caused by abnormal growth of blood vessel cells, although the exact underlying cause for the abnormal growth is unknown. they can also develop in an organ, such as the liver or lung. they usually grow slowly and can sometimes spread to other tissues in the body (metastasize). examples of types of hemangioendotheliomas include spindle cell hemangioma; papillary intralymphatic (dabska tumor); retiform; kaposiform; epithelioid; pseudomyogenic (epithelioid sarcoma-like hemangioendothelioma); and composite. treatment depends on the type of hemangioendothelioma present but typically includes surgical excision (removal). last updated: 7/10/2013

MalaCards based summary: Hemangioendothelioma is related to epithelioid hemangioendothelioma and hemangioma. An important gene associated with Hemangioendothelioma is IFNA2 (interferon, alpha 2), and among its related pathways are Cytokine Network and Cytosolic sensors of pathogen-associated DNA. The compounds mizoribine and intron a have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and bone, and related mouse phenotypes are cardiovascular system and liver/biliary system.

Wikipedia:65 Hemangioendothelioma is used to describe a group of vascular neoplasms that may be considered benign as... more...

Aliases & Classifications for Hemangioendothelioma

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Sources:
43NIH Rare Diseases, 45Novoseek, 62UMLS
See all sources

Hemangioendothelioma, Aliases & Descriptions:

Name: Hemangioendothelioma 43 45 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Hemangioendothelioma

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Diseases related to Hemangioendothelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 148)
idRelated DiseaseScoreTop Affiliating Genes
1epithelioid hemangioendothelioma31.9IFNA2, FLT4
2hemangioma30.8PECAM1, FLT4, IFNA2
3sarcoma30.7FLT4, IL2, PECAM1, S100B
4angiosarcoma30.6PECAM1, FLT4
5lymphangioma30.2PECAM1, FLT4
6pyogenic granuloma30.1PECAM1, FLT4
7adenocarcinoma30.0PECAM1, PLG, FLT4
8eosinophilia29.9IFNA2, IL2
9hepatitis c29.9IL2, IFNA2
10thrombocytopenia29.8PECAM1, IL2, IFNA2, PLG
11glioblastoma29.8PLG, PECAM1, S100B, FLT4
12melanoma29.7IFNA2, S100B, PLG, IL2, FLT4, PECAM1
13hepatitis10.9
14kaposiform hemangioendothelioma10.9
15epithelioid sarcoma10.4
16mediastinitis10.4
17endotheliitis10.4
18tufted angioma10.3
19spindle cell hemangioma10.3
20hypothyroidism10.2
21thyroiditis10.2
22cervicitis10.2
23cavernous hemangioma10.1
24pericardial effusion10.1
25lymphangiomatosis10.1
26aneurysm10.1
27budd-chiari syndrome10.0
28crohn's disease10.0
29lymphedema10.0
30primary biliary cirrhosis10.0
31histiocytoid hemangioma10.0
32fibroma10.0
33cystic lymphangioma10.0
34cerebritis10.0
35hemangiopericytoma10.0
36hepatoblastoma10.0
37histiocytoma10.0
38meningitis10.0
39pancreatitis10.0
40mesothelioma10.0
41papilloma10.0IFNA2, FLT4
42sezary's disease10.0IL2, IFNA2
43hcl-v10.0IFNA2, IL2
44factor vii deficiency10.0IFNA2, IL2
45mycosis fungoides10.0IFNA2, IL2
46spindle cell sarcoma10.0FLT4, S100B
47leukopenia10.0IL2, IFNA2
48cutaneous t cell lymphoma10.0IL2, IFNA2
49kidney cancer10.0IL2, IFNA2
50renal cell carcinoma10.0IL2, IFNA2

Graphical network of the top 20 diseases related to Hemangioendothelioma:



Diseases related to hemangioendothelioma

Symptoms for Hemangioendothelioma

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Drugs & Therapeutics for Hemangioendothelioma

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Drug clinical trials:

Search ClinicalTrials for Hemangioendothelioma

Search NIH Clinical Center for Hemangioendothelioma

Genetic Tests for Hemangioendothelioma

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Anatomical Context for Hemangioendothelioma

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MalaCards organs/tissues related to Hemangioendothelioma:

33
Liver, Lung, Bone, Endothelial, Lymph node, Heart, Skin, Kidney, Spleen, Thyroid, Spinal cord, Brain, Colon, Breast, Cervix, Bone marrow, Thymus, Small intestine, Pancreas, Salivary gland, Adrenal gland, Ovary, Testis, Tonsil, Monocytes, Tongue

Animal Models for Hemangioendothelioma or affiliated genes

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MGI Mouse Phenotypes related to Hemangioendothelioma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1PLG, IL2, FLT4, PECAM1
2MP:00053708.0PLG, IL2, FLT4, PECAM1
3MP:00053817.8PECAM1, FLT4, IL2, PLG

Publications for Hemangioendothelioma

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Articles related to Hemangioendothelioma:

(show top 50)    (show all 767)
idTitleAuthorsYear
1
The importance of early diagnosis and treatment of kaposiform hemangioendothelioma complicated by Kasabach-Merritt phenomenon. (25692091)
2015
2
Primary epithelioid hemangioendothelioma of the bladder: case report and review of the literature. (25502937)
2015
3
Composite Hemangioendothelioma of the Submandibular Region. (25666464)
2015
4
Case of high-risk epithelioid hemangioendothelioma of the neck. (23019156)
2013
5
Recurrent hepatic epithelioid hemangioendothelioma after orthotopic liver transplantation. (24122824)
2013
6
Hepatic epithelioid hemangioendothelioma treated with irreversible electroporation and antibiotics. (23897957)
2013
7
Management of synchronous vascular and ductal anomalies in living donor liver transplantation for hepatic epithelioid hemangioendothelioma. (24166881)
2013
8
Mediastinal epithelioid hemangioendothelioma with abundant spindle cells and osteoclast-like giant cells mimicking malignant fibrous histiocytoma. (23800015)
2013
9
Retiform hemangioendothelioma on the finger. (22783501)
2012
10
Epithelioid hemangioendothelioma of sphenoid bone: a case report of an unusual case. (22824706)
2012
11
Primary Pulmonary Epithelioid Hemangioendothelioma: A Rare Cause of PET-Negative Pulmonary Nodules. (21869893)
2011
12
Mediastinal epithelioid hemangioendothelioma mimicking a teratoma. (21492982)
2011
13
Pseudomyogenic hemangioendothelioma: a distinctive, often multicentric tumor with indolent behavior. (21263239)
2011
14
Spindle cell hemangioendothelioma of the temporal muscle resected with zygomatic osteotomy: a case report of an unusual intramuscular lesion mimicking sarcoma. (22606579)
2011
15
Epithelioid hemangioendothelioma of nasal cavity. (21346909)
2010
16
Retiform hemangioendothelioma presenting as a hyperhidrotic tumor. (20883275)
2010
17
Lenalidomide stops progression of multifocal epithelioid hemangioendothelioma including intracranial disease. (19898746)
2010
18
Expression of prox1, lymphatic endothelial nuclear transcription factor, in Kaposiform hemangioendothelioma and tufted angioma. (20975337)
2010
19
Inhibiting the VEGF-VEGFR pathway in angiosarcoma, epithelioid hemangioendothelioma, and hemangiopericytoma/solitary fibrous tumor. (20485168)
2010
20
Education and imaging. Hepatobiliary and pancreatic: Epithelioid hemangioendothelioma. (19335787)
2009
21
Vincristine and corticosteroids as first-line treatment of Kasabach-Merritt syndrome in kaposiform hemangioendothelioma. (19426625)
2009
22
Nodal and extranodal soft tissue polymorphous hemangioendothelioma: a case report and review of the literature. (19366064)
2009
23
Hepatic epithelioid hemangioendothelioma (HEH) at MRI using reticuloendothelial system (RES)-specific contrast agent: the "bright-bright sign" rather than the "bright-dark sign". (19306449)
2009
24
Epithelioid hemangioendothelioma of the oral cavity: a case report. (18587215)
2008
25
Pulmonary epithelioid hemangioendothelioma: report of three cases. (18751952)
2008
26
Meningel intracranial epithelioid hemangioendothelioma: case report and literature review. (18278439)
2008
27
Liver transplantation for hepatic epithelioid hemangioendothelioma: a case series. (17484250)
2007
28
Spindle cell hemangioendothelioma. (17388212)
2007
29
Spindle cell hemangioma and epithelioid hemangioendothelioma arising in an area of lymphedema. (16778491)
2006
30
Multifocal penile epithelioid hemangioendothelioma masquerading as superficial penile vein thrombosis. (16979710)
2006
31
Incidental in vivo detection of an epithelioid hemangioendothelioma of the mitral valve. (16185295)
2005
32
Epithelioid hemangioendothelioma of the spine. Report of two cases. (16302636)
2005
33
Right upper quadrant pain and fever in a 41-year-old man. Epithelioid hemangioendothelioma of the liver with metastasis to porta hepatis lymph nodes and lung. (15859662)
2005
34
A key angiogenic role of monocyte chemoattractant protein-1 in hemangioendothelioma proliferation. (15163622)
2004
35
Pathology quiz case 2. Diagnosis: Kaposiform hemangioendothelioma (KHE). (15313873)
2004
36
Malignant intracranial epithelioid hemangioendothelioma presumably originating from the lung: case report. (15164990)
2004
37
Transformation between Kaposiform hemangioendothelioma and tufted angioma. (12771476)
2003
38
Pulmonary epithelioid hemangioendothelioma coexistent with pulmonary metastasis of thyroid cancer. (11518122)
2001
39
Vascular endothelial growth factor receptor-3 (VEGFR-3): a marker of vascular tumors with presumed lymphatic differentiation, including Kaposi's sarcoma, kaposiform and Dabska-type hemangioendotheliomas, and a subset of angiosarcomas. (10697276)
2000
40
Epithelioid hemangioendothelioma of the liver--characteristics on magnetic resonance imaging: case report. (10659062)
1999
41
Kaposiform hemangioendothelioma: a locally aggressive vascular tumor. (9591789)
1998
42
Successful multimodal therapy for kaposiform hemangioendothelioma complicated by Kasabach-Merritt phenomenon: case report and review of the literature. (9658430)
1998
43
Epithelioid hemangioendothelioma of soft tissue: report of a case with ultrastructural observations. (9491218)
1998
44
Human angiostatin inhibits murine hemangioendothelioma tumor growth in vivo. (9393749)
1997
45
Malignant epithelioid hemangioendothelioma of the tibia associated with a bone infarct in a patient who had Gaucher disease. A case report. (7744904)
1995
46
CT of pulmonary epithelioid hemangioendothelioma. (8040439)
1994
47
Cutaneous epithelioid hemangioendothelioma without systemic involvement. (8517499)
1993
48
Epithelioid hemangioendothelioma of the lung (intravascular bronchioloalveolar tumor) in a young girl. (1661888)
1991
49
A case of malignant hemangioendothelioma effectively treated with intra-arterial continuous infusion of interleukin-2]. (1877838)
1991
50
Malignant epithelioid hemangioendothelioma at the site of a hip prosthesis. (3381668)
1988

Variations for Hemangioendothelioma

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Expression for genes affiliated with Hemangioendothelioma

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Search GEO for disease gene expression data for Hemangioendothelioma.

Pathways for genes affiliated with Hemangioendothelioma

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Pathways related to Hemangioendothelioma according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IL2, IFNA2
2
Show member pathways
9.5S100B, IFNA2
3
Show member pathways
9.5S100B, IFNA2
49.4FLT4, PECAM1
5
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.1PLG, IL2
6
Show member pathways
9.1FLT4, IFNA2, IL2
7
Show member pathways
9.1FLT4, IFNA2, IL2
89.1FLT4, IFNA2, IL2
9
Show member pathways
9.0PLG, PECAM1
10
Show member pathways
8.7PLG, IL2, IFNA2
11
Show member pathways
8.7PLG, IL2, FLT4
12
Show member pathways
8.6PLG, IFNA2, PECAM1

Compounds for genes affiliated with Hemangioendothelioma

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Compounds related to Hemangioendothelioma according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idCompoundScoreTop Affiliating Genes
1mizoribine4510.0IL2, IFNA2
2intron a4510.0IL2, IFNA2
3fotemustine45 1311.0IFNA2, IL2
4cidofovir45 1311.0IFNA2, IL2
5pentostatin45 61 30 1313.0IL2, IFNA2
6levamisole45 1311.0IL2, IFNA2
7dacarbazine45 1311.0IFNA2, IL2
8temozolomide45 1310.9IFNA2, IL2
9isotretinoin45 1310.9IFNA2, IL2
10bcnu459.9IFNA2, IL2
11con a459.9IL2, IFNA2
12sunitinib45 51 1311.9FLT4, IL2
132,5-oligoadenylate459.9IFNA2, IL2
143-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.9IFNA2, S100B
15ribavirin45 51 1311.8IFNA2, IL2
16ifn-alpha459.8IL2, IFNA2
17sorafenib45 51 1311.8IL2, FLT4
18neopterin459.8IFNA2, IL2
19rituximab45 51 1311.8IL2, IFNA2
20vinblastine45 51 1311.8IL2, IFNA2
21colchicine45 61 3 30 1313.7S100B, IFNA2
22zidovudine45 51 1311.7IFNA2, IL2
23mitomycin c459.5IFNA2, IL2
24azathioprine45 3 51 1312.4IL2, IFNA2
25carboplatin45 51 1311.4PLG, IFNA2
26histamine45 30 2611.3PECAM1, IFNA2, IL2
27rapamycin459.2IL2, FLT4, PECAM1
28paraffin459.2S100B, FLT4, PECAM1
29thalidomide45 51 61 1312.2IFNA2, IL2, PLG
30cyclosporin a45 30 6111.1S100B, IL2, PECAM1
31histidine459.1S100B, PLG, IFNA2
32tamoxifen45 51 30 1312.1IFNA2, IL2, PLG
33paclitaxel45 51 1311.1S100B, PLG, FLT4
34dexamethasone45 51 30 1312.0S100B, IL2, FLT4
35p003459.0S100B, PECAM1
36matrigel459.0PLG, FLT4, PECAM1
37hematoxylin459.0S100B, PLG, PECAM1
38estrogen458.9PECAM1, FLT4, IFNA2, S100B
39retinoic acid45 269.9S100B, IFNA2, FLT4, PECAM1
40steroid458.8IFNA2, PLG, S100B
41heparin45 30 26 1311.8PECAM1, PLG, S100B
42nitric oxide45 26 1310.5S100B, PLG, PECAM1
43cysteine458.5S100B, PLG, IFNA2, PECAM1
44glucose458.5PECAM1, IFNA2, PLG, S100B
45lipid458.5PECAM1, IFNA2, PLG, S100B
46serine458.3S100B, PLG, IL2, PECAM1
47oxygen45 269.1PECAM1, FLT4, IFNA2, PLG, S100B
48thymidine45 269.0PECAM1, IFNA2, IL2, PLG, S100B
49vegf457.6S100B, PLG, IL2, IFNA2, FLT4, PECAM1
50tyrosine457.6PECAM1, FLT4, IFNA2, IL2, PLG, S100B

GO Terms for genes affiliated with Hemangioendothelioma

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Cellular components related to Hemangioendothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055767.7IFNA2, IL2, PLG, S100B, FLT4
2extracellular spaceGO:00056157.3S100B, PLG, IL2, IFNA2, PECAM1

Biological processes related to Hemangioendothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet degranulationGO:00025769.0PLG, PECAM1
2positive regulation of cell proliferationGO:00082848.9S100B, IL2, FLT4
3blood coagulationGO:00075968.3PLG, IFNA2, PECAM1

Products for genes affiliated with Hemangioendothelioma

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Sources for Hemangioendothelioma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet