MCID: HMN016
MIFTS: 38

Hemangioendothelioma malady

Summaries for Hemangioendothelioma

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42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 The term hemangioendothelioma describes several types of vascular neosplasms and includes both non-cancerous (benign) and cancerous (malignant) growths. the term has also been applied to those that show "borderline" behavior, intermediate between entirely benign hemangiomas and highly malignant angiosarcomas. hemangioendotheliomas are caused by abnormal growth of blood vessel cells, although the exact underlying cause for the abnormal growth is unknown. they can also develop in an organ, such as the liver or lung. they usually grow slowly and can sometimes spread to other tissues in the body (metastasize). examples of types of hemangioendotheliomas include spindle cell hemangioma; papillary intralymphatic (dabska tumor); retiform; kaposiform; epithelioid; pseudomyogenic (epithelioid sarcoma-like hemangioendothelioma); and composite. treatment depends on the type of hemangioendothelioma present but typically includes surgical excision (removal). last updated: 7/10/2013

MalaCards: Hemangioendothelioma is related to hepatitis and hemangioma. An important gene associated with Hemangioendothelioma is IFNA2 (interferon, alpha 2), and among its related pathways are NF-KappaB Family Pathway and Platelet degranulation . The compounds sialic acid and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include liver and lung, and related mouse phenotypes are integument and muscle.

Wikipedia:63 Hemangioendothelioma is used to describe a group of vascular neoplasms that may be considered benign as... more...

Aliases & Classifications for Hemangioendothelioma

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42NIH Rare Diseases, 44Novoseek, 60UMLS
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Aliases & Descriptions:

hemangioendothelioma 42 44 60


Related Diseases for Hemangioendothelioma

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17GeneCards, 18GeneDecks
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Diseases related to Hemangioendothelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 234)
idRelated DiseaseScoreTop Affiliating Genes
1hepatitis31.3IFNA2, CAV1
2hemangioma30.6PECAM1, CD34, PROX1, F13A1, FLT4, FLI1
3sarcoma30.6PGF, CD34, F13A1, FLT1, FLT4, FLI1
4angiosarcoma30.5IL2, EDN1
5epithelioid sarcoma30.5CALB2, CD34
6epithelioid hemangioendothelioma30.2IFNA2, FLT4, CD34
7lymphangioma30.1PDPN, FLT4, PROX1, CD34, PECAM1
8kaposi's sarcoma29.9CD34
9hemangioma of liver29.9IFNA2, VHL
10lymphedema29.9PDPN, FLT4, PROX1
11hemangiopericytoma29.9S100B, MDM2, F13A1, CD34
12adenocarcinoma29.9PECAM1, PLG, PGR, CD34, F13A1, FLT4
13peritonitis29.7PECAM1
14acquired immunodeficiency syndrome29.7IL2
15neutropenia29.7CD34, IFNA2
16vasculitis29.7IFNA2
17spindle cell sarcoma29.7FLT4, S100B
18lipoma29.7MDM2, CD34
19leiomyoma29.7S100B, CD34, PGR
20fibrous histiocytoma29.7S100B, F13A1, CD34
21liposarcoma29.7CD34, FLI1, MDM2, CALB2
22peripheral primitive neuroectodermal tumor29.7FLI1, MDM2, S100B
23liver cirrhosis29.7CD34, EDN1, IFNA2, CAV1
24thrombocytopenia29.7IFNA2, FLI1, CD34, IL2, PLG, PECAM1
25adenoma29.7VHL, CALB2, CAV1, FLT4, FLT1
26leiomyosarcoma29.7CALB2, S100B, MDM2, CD34, PGR
27paraganglioma29.7S100B, VHL
28meningioma29.7CALB2, S100B, PDPN, FLT1, CD34, PGF
29glioblastoma multiforme29.7VHL, CAV1, S100B, PDPN, MDM2, FLT4
30melanoma29.7S100B, IFNA2, CAV1, CALB2, PDPN, MDM2
31hepatitis a10.6
32mediastinitis10.4
33kaposiform hemangioendothelioma10.3
34spindle cell hemangioma10.2
35hypothyroidism10.2
36thyroiditis10.2
37cavernous hemangioma10.1
38cervicitis10.1
39pericardial effusion10.1
40laryngeal benign neoplasm10.0FLT4
41glomerulonephritis10.0PECAM1
42myelodysplastic syndromes10.0CD34
43capillary hemangioma10.0CD34
44histiocytosis10.0S100B
45hepatitis c10.0IFNA2
46malignant pleural mesothelioma10.0CALB2
47malaria10.0PECAM1
48dermatofibrosarcoma10.0MDM2
49dermatitis10.0F13A1
50eye disease10.0MDM2

Graphical network of the top 20 diseases related to Hemangioendothelioma:



Diseases related to hemangioendothelioma

Clinical Features for Hemangioendothelioma

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Drugs & Therapeutics for Hemangioendothelioma

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Hemangioendothelioma

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Anatomical Context for Hemangioendothelioma

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32MalaCards
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MalaCards organs/tissues related to Hemangioendothelioma:

32
Liver, Lung

Animal Models for Hemangioendothelioma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Hemangioendothelioma:

36 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.0CAV1, S100B, MDM2, CD34, PLG
2MP:000536910.0VHL, CAV1, MDM2, FLI1, FLT1
3MP:000539010.0PDPN, PGR, PECAM1
4MP:00053799.8PLG, IL2, PROX1, CAV1
5MP:00053899.7VHL, CAV1, WWTR1, FLT4, FLT1, PLG
6MP:00053809.5VHL, EDN1, PGF, PGR
7MP:00020069.5VHL, MDM2, FLI1, CD34, PGF, PGR
8MP:00053889.5CAV1, PDPN, WWTR1, F13A1, PROX1, PLG
9MP:00053679.4VHL, CAV1, WWTR1, EDN1, PLG, PECAM1
10MP:00053709.4VHL, CAV1, MDM2, FLI1, FLT4, PROX1
11MP:00028739.1VHL, CALB2, S100B, EDN1, MDM2, FLT4
12MP:00053769.0PROX1, F13A1, WWTR1, PDPN, CD34, PGF
13MP:00053819.0VHL, CAV1, PDPN, WWTR1, EDN1, MDM2
14MP:00053978.9VHL, CAV1, MDM2, FLI1, FLT1, F13A1
15MP:00053848.8VHL, CAV1, MDM2, FLI1, FLT1, PROX1
16MP:00053868.7PDPN, S100B, CAV1, CALB2, WWTR1, MDM2
17MP:00053788.6VHL, CAV1, PDPN, WWTR1, MDM2, FLI1
18MP:00107688.4MDM2, EDN1, WWTR1, PDPN, CAV1, VHL
19MP:00053878.2FLI1, MDM2, WWTR1, PDPN, CAV1, VHL
20MP:00053858.1PECAM1, VHL, CAV1, PDPN, WWTR1, EDN1

Publications for Hemangioendothelioma

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Genetic Variations for Hemangioendothelioma

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Expression for genes affiliated with Hemangioendothelioma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemangioendothelioma

Search GEO for disease gene expression data for Hemangioendothelioma.

Pathways for genes affiliated with Hemangioendothelioma

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51QIAGEN, 53Reactome, 52R&D Systems, 49PharmGKB, 55SinoBiological, 12EMD Millipore, 4Cell Signaling Technology, 59Tocris Bioscience, 37NCBI BioSystems Database, 29KEGG
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Pathways related to Hemangioendothelioma according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.3PGF
2
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10.0F13A1, PLG, PECAM1
310.0FLT1, FLT4, MDM2
4
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10.0PLG, FLT1, MDM2
510.0MDM2, EDN1, VHL
6
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10.0FLT4, FLT1, PGF
7
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10.0PGF, FLT1, FLT4
8
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10.0FLT4, FLT1, PGF
99.9VHL, FLT4, FLT1, PECAM1
10
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9.9MDM2, FLT4, FLT1, IL2
119.8FLI1, CD34, IL2, PECAM1
12
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9.8MDM2, FLT4, FLT1, PGF
13
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9.8CAV1, FLT4, FLT1, PGF
14
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9.7IFNA2, FLT4, FLT1, PGF, IL2
15
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9.7IL2, PGF, FLT1, FLT4, MDM2
16
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9.7CAV1, FLT4, FLT1, PGF, IL2
17
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9.7PGF, FLT1, FLT4, CAV1, VHL
18
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9.6IL2, CD34, MDM2, S100B, IFNA2, VHL
199.6IFNA2, MDM2, FLT4, FLT1, PGF, IL2
20
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8.8S100B, WWTR1, EDN1, MDM2, FLT4, FLT1

Compounds for genes affiliated with Hemangioendothelioma

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Hemangioendothelioma according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1sialic acid4410.6PECAM1
2cycloheximide4410.6CAV1
3estrogen4410.5F13A1, CALB2
4zm 323881 hydrochloride5910.5FLT4, FLT1
5zm 306416 hydrochloride5910.5FLT4, FLT1
6ki 87515910.5FLT4, FLT1
7dmh45910.5FLT1, FLT4
8thapsigargin44 5911.5MDM2
9indomethacin44 59 28 1113.5PGF, PGR
10tamoxifen44 49 28 1113.4IL2, PLG, PGR
11sorafenib44 49 1112.3FLT4, FLT1, IL2, VHL
12thalidomide44 49 59 1113.3IFNA2, CAV1, PLG, IL2
13p0034410.2PECAM1, FLT1, S100B, MDM2
14cyclosporin a44 28 5912.2PECAM1, PGR, S100B, EDN1
15dexamethasone44 49 28 1113.2S100B, CAV1, MDM2
16intron a4410.2IL2, IFNA2
17glucose4410.2CAV1, PGF, IFNA2, FLT1
18sunitinib44 49 1112.1IL2, PGF, FLT1, FLT4, VHL
19b 7234410.1PDPN, F13A1, CALB2, S100B
20cyclophosphamide44 49 1112.1PGR, IFNA2, MDM2, IL2
21steroid4410.1CALB2, MDM2, PLG, IFNA2, CAV1
22ribonucleic acid4410.0PGF, FLT1, PGR, PECAM1, IFNA2
23rapamycin4410.0FLT4, FLT1, IL2, PECAM1, MDM2, VHL
24bq78844 2811.0CAV1, EDN1
25prostacyclin4410.0CAV1, PGF, FLT1, PECAM1, EDN1
265-aza-2deoxycytidine4410.0CAV1, PGR, MDM2, VHL
27agar4410.0PECAM1, PGR, CAV1, IFNA2, MDM2, CD34
28iron44 2411.0VHL, IFNA2, S100B, MDM2, F13A1, CAV1
29actinomycin d4410.0PECAM1, IL2, MDM2, VHL, EDN1
30matrigel4410.0PGF, FLT1, FLT4, CAV1, PLG, PECAM1
31serine4410.0PLG, CAV1, PECAM1, VHL, S100B, FLT1
32doxorubicin44 49 1112.0FLT1, PGR, MDM2, CAV1, IFNA2
33mizoribine449.9IFNA2, IL2
34genistein44 28 59 2 11 2414.9EDN1, CAV1, MDM2, FLT1, PGR, IL2
35lysine449.9IFNA2, PLG, F13A1, MDM2, VHL
36paclitaxel44 49 1111.8S100B, PGR, PLG, FLT4, MDM2, CALB2
37heparin44 28 11 2412.8PLG, PECAM1, S100B, CAV1, FLT1, F13A1
38cisplatin44 49 59 1112.8IFNA2, MDM2, FLT1, IL2, CAV1
39cysteine449.7PLG, CAV1, IFNA2, MDM2, PGR, PECAM1
40retinoic acid44 2410.7PECAM1, FLT4, PGR, CD34, IFNA2, S100B
41hematoxylin449.6S100B, FLT1, F13A1, CD34, PLG, PECAM1
42phosphatidylinositol449.5CAV1, VHL, EDN1, MDM2, FLT1, PGF
43progesterone44 59 28 11 2413.4CAV1, CALB2, IFNA2, FLT1, S100B, PGR
44thymidine44 2410.4IFNA2, IL2, CD34, PLG, PECAM1, S100B
45nitric oxide44 11 2411.3VHL, CALB2, S100B, EDN1, MDM2, FLT1
46oxygen44 2410.3IFNA2, S100B, EDN1, MDM2, PLG, PGF
47calcium44 49 11 2412.1S100B, FLT1, CALB2, PECAM1, PLG, PGF
48paraffin448.9FLT1, F13A1, CD34, PGR, PECAM1, PGF
49tyrosine448.7CD34, PGF, IL2, PLG, S100B, PECAM1
50vegf448.2S100B, FLT4, MDM2, EDN1, PDPN, IFNA2

GO Terms for genes affiliated with Hemangioendothelioma

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16Gene Ontology
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Cellular components related to Hemangioendothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.3S100B, EDN1, FLT4, F13A1, PGF, IL2
2extracellular spaceGO:0056159.0PECAM1, IFNA2, S100B, EDN1, FLT1, PGF

Biological processes related to Hemangioendothelioma according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1glomerular endothelium developmentGO:07201110.4PECAM1, CD34
2positive regulation of odontogenesisGO:04248210.3CD34, EDN1
3positive regulation of sarcomere organizationGO:06029810.3PROX1, EDN1
4sprouting angiogenesisGO:00204010.3PGF, FLT1, FLT4
5vascular endothelial growth factor receptor signaling pathwayGO:04801010.3FLT4, FLT1, PGF
6lymphangiogenesisGO:00194610.2PDPN, FLT4, PROX1
7positive regulation of endothelial cell migrationGO:01059510.2EDN1, FLT4, PROX1
8positive regulation of endothelial cell proliferationGO:00193810.1FLT4, PROX1, PGF
9negative regulation of blood coagulationGO:03019510.1CD34, EDN1
10negative regulation of gene expressionGO:01062910.1IFNA2, CD34, PGR
11cellular response to hypoxiaGO:07145610.1MDM2, S100B, VHL
12platelet degranulationGO:00257610.0PECAM1, PLG, F13A1
13negative regulation of nitric oxide biosynthetic processGO:04501910.0CAV1, CD34
14cell-cell signalingGO:00726710.0IL2, PGR, PGF, EDN1, IFNA2
15blood coagulationGO:0075969.9PECAM1, PLG, F13A1, IFNA2, CAV1
16negative regulation of transcription from RNA polymerase II promoterGO:0001229.7VHL, CAV1, WWTR1, EDN1, MDM2, PROX1
17positive regulation of angiogenesisGO:0457669.6FLT1, CD34, PGF
18positive regulation of cell proliferationGO:0082849.3IL2, S100B, WWTR1, EDN1, MDM2, FLT4

Molecular functions related to Hemangioendothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor-activated receptor activityGO:0050219.9FLT4, FLT1
2enzyme bindingGO:0198999.9PGR, MDM2, CAV1, VHL
3protein bindingGO:0055158.3PECAM1, VHL, CAV1, IFNA2, S100B, WWTR1

Products for genes affiliated with Hemangioendothelioma

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Sources for Hemangioendothelioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet