MCID: HMN016
MIFTS: 46

Hemangioendothelioma malady

Rare diseases category
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Summaries for Hemangioendothelioma

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NIH Rare Diseases:42 The term hemangioendothelioma describes several types of vascular neosplasms and includes both non-cancerous (benign) and cancerous (malignant) growths. the term has also been applied to those that show "borderline" behavior, intermediate between entirely benign hemangiomas and highly malignant angiosarcomas. hemangioendotheliomas are caused by abnormal growth of blood vessel cells, although the exact underlying cause for the abnormal growth is unknown. they can also develop in an organ, such as the liver or lung. they usually grow slowly and can sometimes spread to other tissues in the body (metastasize). examples of types of hemangioendotheliomas include spindle cell hemangioma; papillary intralymphatic (dabska tumor); retiform; kaposiform; epithelioid; pseudomyogenic (epithelioid sarcoma-like hemangioendothelioma); and composite. treatment depends on the type of hemangioendothelioma present but typically includes surgical excision (removal). last updated: 7/10/2013

MalaCards based summary: Hemangioendothelioma is related to epithelioid hemangioendothelioma and angiosarcoma. An important gene associated with Hemangioendothelioma is IFNA2 (interferon, alpha 2), and among its related pathways are Cytokine Network and Cytosolic sensors of pathogen-associated DNA. The compounds intron a and mizoribine have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and bone, and related mouse phenotypes are cardiovascular system and liver/biliary system.

Wikipedia:65 Hemangioendothelioma is used to describe a group of vascular neoplasms that may be considered benign as... more...

Aliases & Classifications for Hemangioendothelioma

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Sources:
42NIH Rare Diseases, 44Novoseek, 62UMLS
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Hemangioendothelioma, Aliases & Descriptions:

Name: Hemangioendothelioma 42 44 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


Related Diseases for Hemangioendothelioma

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Diseases related to Hemangioendothelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 148)
idRelated DiseaseScoreTop Affiliating Genes
1epithelioid hemangioendothelioma32.3IFNA2, FLT4
2angiosarcoma30.9PECAM1, FLT4
3hemangioma30.8PECAM1, FLT4, IFNA2
4lymphangioma30.5PECAM1, FLT4
5sarcoma30.3FLT4, IL2, PECAM1, S100B
6eosinophilia30.1IFNA2, IL2
7pyogenic granuloma30.1PECAM1, FLT4
8hepatitis c30.1IL2, IFNA2
9kaposi's sarcoma30.1IFNA2, FLT4, PECAM1
10adenocarcinoma29.6PECAM1, PLG, FLT4
11thrombocytopenia29.3PECAM1, IL2, IFNA2, PLG
12glioblastoma29.2PLG, PECAM1, S100B, FLT4
13melanoma28.6IFNA2, S100B, PLG, IL2, FLT4, PECAM1
14hepatitis10.9
15kaposiform hemangioendothelioma10.9
16mediastinitis10.4
17epithelioid sarcoma10.4
18endotheliitis10.4
19tufted angioma10.3
20papilloma10.3IFNA2, FLT4
21spindle cell hemangioma10.3
22sezary's disease10.2IL2, IFNA2
23hypothyroidism10.2
24thyroiditis10.2
25hairy cell leukemia10.2IFNA2, IL2
26factor vii deficiency10.2IFNA2, IL2
27mycosis fungoides10.2IFNA2, IL2
28spindle cell sarcoma10.2FLT4, S100B
29leukopenia10.2IL2, IFNA2
30cutaneous t cell lymphoma10.2IL2, IFNA2
31kidney rhabdoid cancer10.2IL2, IFNA2
32kidney cancer10.2IL2, IFNA2
33lichen planus10.2PECAM1, IFNA2
34cervicitis10.2
35cavernous hemangioma10.1
36pericardial effusion10.1
37lymphangiomatosis10.1
38aneurysm10.1
39graft versus host disease10.1PECAM1, IL2
40vascular cancer10.1FLT4, PLG
41chronic lymphocytic leukemia10.1IL2, PECAM1
42uveal melanoma10.0PLG, S100B
43lymphedema10.0
44primary biliary cirrhosis10.0
45histiocytoid hemangioma10.0
46fibroma10.0
47cystic lymphangioma10.0
48cerebritis10.0
49hemangiopericytoma10.0
50hepatoblastoma10.0

Graphical network of the top 20 diseases related to Hemangioendothelioma:



Diseases related to hemangioendothelioma

Symptoms for Hemangioendothelioma

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Drugs & Therapeutics for Hemangioendothelioma

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Drug clinical trials:

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Genetic Tests for Hemangioendothelioma

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Anatomical Context for Hemangioendothelioma

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MalaCards organs/tissues related to Hemangioendothelioma:

32
Liver, Lung, Bone, Endothelial, Lymph node, Heart, Skin, Kidney, Spleen, Thyroid, Spinal cord, Brain, Colon, Breast, Cervix, Bone marrow, Thymus, Small intestine, Pancreas, Salivary gland, Ovary, Testis, Tonsil, Monocytes, Tongue

Animal Models for Hemangioendothelioma or affiliated genes

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MGI Mouse Phenotypes related to Hemangioendothelioma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1PECAM1, FLT4, IL2, PLG
2MP:00053708.0PECAM1, FLT4, IL2, PLG
3MP:00053817.8PECAM1, FLT4, IL2, PLG

Publications for Hemangioendothelioma

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Articles related to Hemangioendothelioma:

(show top 50)    (show all 744)
idTitleAuthorsYear
1
Case of high-risk epithelioid hemangioendothelioma of the neck. (23019156)
2013
2
A rare case of primary nodal hemangioendothelioma. (24260072)
2013
3
Hepatic epithelioid hemangioendothelioma treated with irreversible electroporation and antibiotics. (23897957)
2013
4
Management of synchronous vascular and ductal anomalies in living donor liver transplantation for hepatic epithelioid hemangioendothelioma. (24166881)
2013
5
Mediastinal epithelioid hemangioendothelioma with abundant spindle cells and osteoclast-like giant cells mimicking malignant fibrous histiocytoma. (23800015)
2013
6
Retiform hemangioendothelioma on the finger. (22783501)
2012
7
Epithelioid hemangioendothelioma of sphenoid bone: a case report of an unusual case. (22824706)
2012
8
Primary Pulmonary Epithelioid Hemangioendothelioma: A Rare Cause of PET-Negative Pulmonary Nodules. (21869893)
2011
9
Mediastinal epithelioid hemangioendothelioma mimicking a teratoma. (21492982)
2011
10
Pseudomyogenic hemangioendothelioma: a distinctive, often multicentric tumor with indolent behavior. (21263239)
2011
11
Spindle cell hemangioendothelioma of the temporal muscle resected with zygomatic osteotomy: a case report of an unusual intramuscular lesion mimicking sarcoma. (22606579)
2011
12
Epithelioid hemangioendothelioma of nasal cavity. (21346909)
2010
13
Retiform hemangioendothelioma presenting as a hyperhidrotic tumor. (20883275)
2010
14
Lenalidomide stops progression of multifocal epithelioid hemangioendothelioma including intracranial disease. (19898746)
2010
15
Expression of prox1, lymphatic endothelial nuclear transcription factor, in Kaposiform hemangioendothelioma and tufted angioma. (20975337)
2010
16
Inhibiting the VEGF-VEGFR pathway in angiosarcoma, epithelioid hemangioendothelioma, and hemangiopericytoma/solitary fibrous tumor. (20485168)
2010
17
Education and imaging. Hepatobiliary and pancreatic: Epithelioid hemangioendothelioma. (19335787)
2009
18
Vincristine and corticosteroids as first-line treatment of Kasabach-Merritt syndrome in kaposiform hemangioendothelioma. (19426625)
2009
19
Nodal and extranodal soft tissue polymorphous hemangioendothelioma: a case report and review of the literature. (19366064)
2009
20
Hepatic epithelioid hemangioendothelioma (HEH) at MRI using reticuloendothelial system (RES)-specific contrast agent: the "bright-bright sign" rather than the "bright-dark sign". (19306449)
2009
21
Epithelioid hemangioendothelioma of the oral cavity: a case report. (18587215)
2008
22
Pulmonary epithelioid hemangioendothelioma: report of three cases. (18751952)
2008
23
Meningel intracranial epithelioid hemangioendothelioma: case report and literature review. (18278439)
2008
24
Epitheloid hemangioendothelioma of urinary bladder. (19468406)
2008
25
Liver transplantation for hepatic epithelioid hemangioendothelioma: a case series. (17484250)
2007
26
Spindle cell hemangioendothelioma. (17388212)
2007
27
Pulmonary metastasis from hepatic epithelioid hemangioendothelioma; report of a case]. (17564071)
2007
28
Spindle cell hemangioma and epithelioid hemangioendothelioma arising in an area of lymphedema. (16778491)
2006
29
Multifocal penile epithelioid hemangioendothelioma masquerading as superficial penile vein thrombosis. (16979710)
2006
30
Incidental in vivo detection of an epithelioid hemangioendothelioma of the mitral valve. (16185295)
2005
31
Epithelioid hemangioendothelioma of the spine. Report of two cases. (16302636)
2005
32
Right upper quadrant pain and fever in a 41-year-old man. Epithelioid hemangioendothelioma of the liver with metastasis to porta hepatis lymph nodes and lung. (15859662)
2005
33
A key angiogenic role of monocyte chemoattractant protein-1 in hemangioendothelioma proliferation. (15163622)
2004
34
Pathology quiz case 2. Diagnosis: Kaposiform hemangioendothelioma (KHE). (15313873)
2004
35
Malignant intracranial epithelioid hemangioendothelioma presumably originating from the lung: case report. (15164990)
2004
36
Epithelioid hemangioendothelioma of the liver with F-18 FDG PET imaging. (15545895)
2004
37
Pulmonary epithelioid hemangioendothelioma coexistent with pulmonary metastasis of thyroid cancer. (11518122)
2001
38
Vascular endothelial growth factor receptor-3 (VEGFR-3): a marker of vascular tumors with presumed lymphatic differentiation, including Kaposi's sarcoma, kaposiform and Dabska-type hemangioendotheliomas, and a subset of angiosarcomas. (10697276)
2000
39
Epithelioid hemangioendothelioma of the liver--characteristics on magnetic resonance imaging: case report. (10659062)
1999
40
Kaposiform hemangioendothelioma: a locally aggressive vascular tumor. (9591789)
1998
41
Successful multimodal therapy for kaposiform hemangioendothelioma complicated by Kasabach-Merritt phenomenon: case report and review of the literature. (9658430)
1998
42
Epithelioid hemangioendothelioma of soft tissue: report of a case with ultrastructural observations. (9491218)
1998
43
Human angiostatin inhibits murine hemangioendothelioma tumor growth in vivo. (9393749)
1997
44
Malignant epithelioid hemangioendothelioma of the tibia associated with a bone infarct in a patient who had Gaucher disease. A case report. (7744904)
1995
45
CT of pulmonary epithelioid hemangioendothelioma. (8040439)
1994
46
Cutaneous epithelioid hemangioendothelioma without systemic involvement. (8517499)
1993
47
Epithelioid hemangioendothelioma of the lung (intravascular bronchioloalveolar tumor) in a young girl. (1661888)
1991
48
A case of malignant hemangioendothelioma effectively treated with intra-arterial continuous infusion of interleukin-2]. (1877838)
1991
49
Malignant epithelioid hemangioendothelioma at the site of a hip prosthesis. (3381668)
1988
50
Intravascular bronchioloalveolar tumor as a secondary manifestation of an epithelioid hemangioendothelioma. (3818539)
1986

Variations for Hemangioendothelioma

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Expression for genes affiliated with Hemangioendothelioma

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Expression patterns in normal tissues for genes affiliated with Hemangioendothelioma

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Pathways for genes affiliated with Hemangioendothelioma

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Pathways related to Hemangioendothelioma according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IFNA2, IL2
2
Show member pathways
9.5S100B, IFNA2
3
Show member pathways
9.5S100B, IFNA2
49.4PECAM1, FLT4
5
Show member pathways
IL23-mediated signaling events37
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling37
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.1PLG, IL2
6
Show member pathways
9.1IL2, IFNA2, FLT4
7
Show member pathways
9.1IL2, FLT4, IFNA2
89.1IL2, IFNA2, FLT4
9
Show member pathways
9.0PECAM1, PLG
10
Show member pathways
8.7IFNA2, IL2, PLG
11
Show member pathways
8.7PLG, IL2, FLT4
12
Show member pathways
8.6PLG, IFNA2, PECAM1

Compounds for genes affiliated with Hemangioendothelioma

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Compounds related to Hemangioendothelioma according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idCompoundScoreTop Affiliating Genes
1intron a4410.0IL2, IFNA2
2mizoribine4410.0IL2, IFNA2
3fotemustine44 1111.0IL2, IFNA2
4cidofovir44 1111.0IL2, IFNA2
5pentostatin44 61 28 1113.0IL2, IFNA2
6levamisole44 1111.0IL2, IFNA2
7dacarbazine44 1111.0IFNA2, IL2
8temozolomide44 1110.9IFNA2, IL2
9bcnu449.9IL2, IFNA2
10isotretinoin44 1110.9IFNA2, IL2
11con a449.9IFNA2, IL2
12sunitinib44 50 1111.9IL2, FLT4
132,5-oligoadenylate449.9IFNA2, IL2
143-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.9IFNA2, S100B
15ribavirin44 50 1111.8IFNA2, IL2
16ifn-alpha449.8IL2, IFNA2
17sorafenib44 50 1111.8FLT4, IL2
18neopterin449.8IL2, IFNA2
19rituximab44 50 1111.8IFNA2, IL2
20vinblastine44 50 1111.8IFNA2, IL2
21colchicine44 61 2 28 1113.7S100B, IFNA2
22zidovudine44 50 1111.7IFNA2, IL2
23mitomycin c449.5IFNA2, IL2
24azathioprine44 2 50 1112.4IFNA2, IL2
25carboplatin44 50 1111.4PLG, IFNA2
26histamine44 28 2411.3IFNA2, PECAM1, IL2
27rapamycin449.2IL2, FLT4, PECAM1
28paraffin449.2S100B, FLT4, PECAM1
29thalidomide44 50 61 1112.2IFNA2, IL2, PLG
30cyclosporin a44 28 6111.1S100B, PECAM1, IL2
31histidine449.1IFNA2, S100B, PLG
32tamoxifen44 50 28 1112.1PLG, IL2, IFNA2
33paclitaxel44 50 1111.1FLT4, S100B, PLG
34dexamethasone44 50 28 1112.0IL2, S100B, FLT4
35p003449.0PECAM1, S100B
36matrigel449.0PLG, FLT4, PECAM1
37hematoxylin449.0PECAM1, S100B, PLG
38estrogen448.9S100B, IFNA2, PECAM1, FLT4
39retinoic acid44 249.9PECAM1, S100B, IFNA2, FLT4
40steroid448.8IFNA2, PLG, S100B
41heparin44 28 24 1111.8PLG, S100B, PECAM1
42nitric oxide44 24 1110.5PECAM1, PLG, S100B
43cysteine448.5PECAM1, PLG, S100B, IFNA2
44glucose448.5PECAM1, PLG, S100B, IFNA2
45lipid448.5PECAM1, S100B, PLG, IFNA2
46serine448.3IL2, PECAM1, PLG, S100B
47oxygen44 249.1PLG, S100B, IFNA2, FLT4, PECAM1
48thymidine44 249.0S100B, PLG, IL2, PECAM1, IFNA2
49vegf447.6IL2, PECAM1, FLT4, S100B, PLG, IFNA2
50tyrosine447.6PECAM1, FLT4, IFNA2, IL2, PLG, S100B

GO Terms for genes affiliated with Hemangioendothelioma

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Cellular components related to Hemangioendothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.7FLT4, IFNA2, IL2, PLG, S100B
2extracellular spaceGO:0056157.3PECAM1, IFNA2, IL2, PLG, S100B

Biological processes related to Hemangioendothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet degranulationGO:0025769.0PLG, PECAM1
2positive regulation of cell proliferationGO:0082848.9S100B, IL2, FLT4
3blood coagulationGO:0075968.3PLG, IFNA2, PECAM1

Products for genes affiliated with Hemangioendothelioma

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Sources for Hemangioendothelioma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet