MCID: HMN016
MIFTS: 51

Hemangioendothelioma malady

Summaries for Hemangioendothelioma

Sources:
43NIH Rare Diseases, 64Wikipedia, 33MalaCards
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NIH Rare Diseases:43 The term hemangioendothelioma describes several types of vascular neosplasms and includes both non-cancerous (benign) and cancerous (malignant) growths. the term has also been applied to those that show "borderline" behavior, intermediate between entirely benign hemangiomas and highly malignant angiosarcomas. hemangioendotheliomas are caused by abnormal growth of blood vessel cells, although the exact underlying cause for the abnormal growth is unknown. they can also develop in an organ, such as the liver or lung. they usually grow slowly and can sometimes spread to other tissues in the body (metastasize). examples of types of hemangioendotheliomas include spindle cell hemangioma; papillary intralymphatic (dabska tumor); retiform; kaposiform; epithelioid; pseudomyogenic (epithelioid sarcoma-like hemangioendothelioma); and composite. treatment depends on the type of hemangioendothelioma present but typically includes surgical excision (removal). last updated: 7/10/2013

MalaCards: Hemangioendothelioma is related to epithelioid hemangioendothelioma and angiosarcoma. An important gene associated with Hemangioendothelioma is IFNA2 (interferon, alpha 2), and among its related pathways are NF-KappaB Family Pathway and Platelet degranulation . The compounds sialic acid and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver, and related mouse phenotypes are integument and muscle.

Wikipedia:64 Hemangioendothelioma is used to describe a group of vascular neoplasms that may be considered benign as... more...

Aliases & Classifications for Hemangioendothelioma

Sources:
43NIH Rare Diseases, 45Novoseek, 61UMLS
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Aliases & Descriptions:

hemangioendothelioma 43 45 61


Related Diseases for Hemangioendothelioma

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Hemangioendothelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 219)
idRelated DiseaseScoreTop Affiliating Genes
1epithelioid hemangioendothelioma31.8IFNA2, FLT4, CD34
2angiosarcoma30.6IL2, EDN1
3kaposi's sarcoma30.1CD34
4adenocarcinoma30.0PECAM1, PLG, PGR, CD34, F13A1, FLT4
5acquired immunodeficiency syndrome29.8IL2
6vasculitis29.8IFNA2
7angiomatosis29.8VHL
8pyogenic granuloma29.8FLT4, CD34, PECAM1
9spindle cell sarcoma29.8FLT4, S100B
10fibrous histiocytoma29.8S100B, F13A1, CD34
11thrombocytopenia29.8IFNA2, FLI1, CD34, IL2, PLG, PECAM1
12adenoma29.8VHL, CALB2, CAV1, FLT4, FLT1
13paraganglioma29.8S100B, VHL
14kaposiform hemangioendothelioma10.9
15tufted angioma10.3
16spindle cell hemangioma10.3
17n syndrome10.1
18lymphangiomatosis10.1
19histiocytoid hemangioma10.0
20primary biliary cirrhosis10.0
21bone epithelioid hemangioma10.0
22adult syndrome10.0
23cystic lymphangioma10.0
24peritonitis10.0PECAM1
25laryngeal carcinoma10.0FLT4
26glomerulonephritis10.0PECAM1
27myelodysplastic syndromes10.0CD34
28capillary hemangioma10.0CD34
29histiocytosis10.0S100B
30hepatitis c10.0IFNA2
31malignant pleural mesothelioma10.0CALB2
32malaria10.0PECAM1
33dermatofibrosarcoma10.0MDM2
34dermatitis10.0F13A1
35eye disease10.0MDM2
36cystadenoma10.0VHL
37chordoma10.0S100B
38glomus tumor10.0VHL
39lymphangiosarcoma10.0PROX1
40myeloid leukemia10.0CD34
41hepatitis b10.0IL2, IFNA2
42pituitary adenoma10.0CAV1
43neutropenia10.0CD34, IFNA2
44thromboembolism10.0PLG
45synovial sarcoma10.0CD34, FLI1
46primary hyperoxaluria10.0IL2, PLG
47hepatitis10.0IFNA2, CAV1
48neurofibromatosis10.0VHL
49gastrointestinal stromal tumor10.0CD34, S100B
50glaucoma10.0EDN1

Graphical network of the top 20 diseases related to Hemangioendothelioma:



Diseases related to hemangioendothelioma

Clinical Features for Hemangioendothelioma

Drugs & Therapeutics for Hemangioendothelioma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Hemangioendothelioma

Drug clinical trials:

Search ClinicalTrials for Hemangioendothelioma

Search NIH Clinical Center for Hemangioendothelioma

Search CenterWatch for Hemangioendothelioma

Genetic Tests for Hemangioendothelioma

Anatomical Context for Hemangioendothelioma

Sources:
33MalaCards
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MalaCards organs/tissues related to Hemangioendothelioma:

33
Skin, Ovary, Liver, Tongue, Spinal cord, Brain, Kidney, Lymph node, Lung, Spleen, Bone marrow, Thymus, Heart, Small intestine, Colon, Pancreas, Thyroid, Salivary gland, Adrenal gland, Breast, Testis, Cervix, Tonsil, Monocytes, T cells, Endothelial, Fetal brain, Temporal lobe, Occipital lobe, Fetal liver, Fetal lung, Fetal thyroid, Testis germ

Animal Models for Hemangioendothelioma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Hemangioendothelioma:

37 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:001077110.0MDM2, PLG, CD34, S100B, CAV1
2MP:000536910.0FLI1, VHL, CAV1, MDM2, FLT1
3MP:000539010.0PECAM1, PDPN, PGR
4MP:00053799.8CAV1, IL2, PLG, PROX1
5MP:00053899.7FLT4, FLT1, PLG, CAV1, VHL, WWTR1
6MP:00053809.5PGF, EDN1, PGR, VHL
7MP:00020069.5FLI1, PGR, PGF, CD34, IL2, MDM2
8MP:00053889.5PDPN, WWTR1, F13A1, PROX1, PLG, PECAM1
9MP:00053679.4PECAM1, VHL, PLG, CAV1, WWTR1, EDN1
10MP:00053709.4VHL, FLI1, CAV1, PLG, MDM2, FLT4
11MP:00028739.1FLT1, CALB2, S100B, EDN1, FLT4, PROX1
12MP:00053769.0PDPN, PLG, IL2, PGR, CD34, PGF
13MP:00053819.0PROX1, PECAM1, CAV1, PDPN, WWTR1, EDN1
14MP:00053978.9VHL, MDM2, FLI1, F13A1, PROX1, CD34
15MP:00053848.8PROX1, MDM2, VHL, FLI1, PECAM1, PLG
16MP:00053868.7MDM2, WWTR1, PDPN, CALB2, CAV1, FLT1
17MP:00053788.6PROX1, PGF, IL2, PLG, FLI1, FLT1
18MP:00107688.4PGR, FLT4, PLG, PDPN, VHL, WWTR1
19MP:00053878.2WWTR1, MDM2, FLI1, FLT4, FLT1, CD34
20MP:00053858.1PECAM1, VHL, CAV1, PDPN, WWTR1, EDN1

Publications for Hemangioendothelioma

Sources:
51PubMed
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Articles related to Hemangioendothelioma:

(show top 50)    (show all 717)
idTitleAuthorsYear
1
Case of high-risk epithelioid hemangioendothelioma of the neck. (23019156)
2013
2
Management of synchronous vascular and ductal anomalies in living donor liver transplantation for hepatic epithelioid hemangioendothelioma. (24166881)
2013
3
Microscopic Kaposiform hemangioendothelioma with extensive lymphangiomatosis: an extraordinary example of an unusual entity. (23129838)
2013
4
Epithelioid hemangioendothelioma involving bone marrow presenting with persistent anemia. (23456954)
2013
5
Epithelioid hemangioendothelioma of the mastoid: resection for recurrence and adjuvant radiation with 8-year followup. (23424708)
2013
6
Primary epithelioid hemangioendothelioma of the kidney: the first case report in a child and literature review. (23726166)
2013
7
A case of intravascular epithelioid hemangioendothelioma occurring 14 years after coil embolization for an extracranial internal carotid artery aneurysm. (21917400)
2012
8
Successful management of multi-focal hepatic infantile hemangioendothelioma using TACE/surgery followed by maintenance metronomic therapy. (22605610)
2012
9
Epithelioid hemangioendothelioma of the pisiform. (23730246)
2012
10
Activity of angiogenesis inhibitors in metastatic epithelioid hemangioendothelioma: a case report. (23691469)
2012
11
Mediastinal epithelioid hemangioendothelioma mimicking a teratoma. (21492982)
2011
12
Translocation t(7;19)(q22;q13)a89a recurrent chromosome aberration in pseudomyogenic hemangioendothelioma? (21536240)
2011
13
Capillary-lymphatic malformation, kaposiform hemangioendothelioma and delayed Kasabach-Merritt phenomenon. (20403115)
2011
14
Pleural epithelioid hemangioendothelioma in an elderly patient. A case report and review of the literature. (21592613)
2011
15
Bartonella species bacteremia in two patients with epithelioid hemangioendothelioma. (21918021)
2011
16
Thoracic epithelioid hemangioendothelioma: imaging and pathologic features. (21498344)
2011
17
Not all hemangiomas are benign--epithelioid hemangioendothelioma: an aggressive vascular lesion in children. (21787124)
2011
18
Epithelioid hemangioendothelioma of the forearm with radius involvement. Case report. (22145982)
2011
19
Characteristic cytologic findings of epithelioid hemangioendothelioma: A case report and review of literature. (21254460)
2011
20
Retiform hemangioendothelioma presenting as a hyperhidrotic tumor. (20883275)
2010
21
Vascular endothelial growth factor expression in hepatic epithelioid hemangioendothelioma: Implications for treatment and surgical management. (20104492)
2010
22
Epithelioid hemangioendothelioma in the right auricle of an adult, male Rhesus macaque (Macaca mulatta). (20444002)
2010
23
Pulmonary epithelioid hemangioendothelioma presenting as multiple large calcified nodules. (19819604)
2010
24
Epithelioid hemangioendothelioma of the facial bone. (21119482)
2010
25
Laryngeal kaposiform hemangioendothelioma: case report and literature review. (19553040)
2010
26
Picture of the month: kaposiform hemangioendothelioma with Kasabach-Merritt phenomenon. (20368493)
2010
27
CD10 is expressed in most epithelioid hemangioendotheliomas: a potential diagnostic pitfall. (19961253)
2009
28
Coexistent hepatic and pulmonary epitheloid hemangioendothelioma. (19282569)
2009
29
Intraoral epithelioid hemangioendothelioma: an intermediate vascular tumor- a case report. (21528039)
2009
30
Cytologic findings and differential diagnosis in hepatic Epithelioid hemangioendothelioma: a case report. (19068677)
2008
31
Spontaneous regression of a vascular tumor of the skull base--infantile hemangioendothelioma? (18776768)
2008
32
Composite cutaneous hemangioendothelioma on the back. (18496428)
2008
33
Hepatic epithelioid hemangioendothelioma. (17478343)
2007
34
Multifocal penile epithelioid hemangioendothelioma masquerading as superficial penile vein thrombosis. (16979710)
2006
35
Aggressive intracranial and extra-cranial epithelioid hemangioendothelioma: a case report and review of the literature. (16771175)
2006
36
Successful treatment of osteolytic epithelioid hemangioendothelioma with pamidronate. (15971432)
2005
37
Epithelioid hemangioendothelioma of the liver: imaging diagnosis of a rare hepatic tumor. (16479109)
2005
38
Pathology quiz case 2. Diagnosis: Kaposiform hemangioendothelioma (KHE). (15313873)
2004
39
High grade hemangioendothelioma of the temporal bone in a child: a case report. (15467419)
2004
40
Thalidomide inhibits the growth and progression of hepatic epithelioid hemangioendothelioma. (15714004)
2004
41
Kaposiform hemangioendothelioma: the first reported case in a nonhuman animal species. (15557080)
2004
42
Epithelioid hemangioendothelioma of the mandible. (12764686)
2003
43
Epithelioid hemangioendothelioma of the pleura: clinical and radiologic features. (11090371)
2000
44
A case of childhood epithelioid hemangioendothelioma. (10767700)
2000
45
Epithelioid hemangioendothelioma of the lung. (8837341)
1996
46
Hepatic epithelioid hemangioendothelioma. (7597205)
1995
47
Epithelioid hemangioendothelioma of the central nervous system. Immunohistochemical and ultrastructural observations of a pediatric case. (3217280)
1988
48
Epithelioid sarcoma and epithelioid hemangioendothelioma: an immunocytochemical and lectin-histochemical comparison. (3101280)
1987
49
Epithelioid hemangioendothelioma of the liver: a clinicopathologic and follow-up study of 32 cases. (6088383)
1984
50
Blue rubber-bleb nevus syndrome with Masson's vegetant intravascular hemangioendothelioma. (7334159)
1981

Genetic Variations for Hemangioendothelioma

Expression for genes affiliated with Hemangioendothelioma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Hemangioendothelioma

Search GEO for disease gene expression data for Hemangioendothelioma.

Pathways for genes affiliated with Hemangioendothelioma

Sources:
52QIAGEN, 54Reactome, 53R&D Systems, 50PharmGKB, 56SinoBiological, 12EMD Millipore, 4Cell Signaling Technology, 60Tocris Bioscience, 38NCBI BioSystems Database, 30KEGG
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Pathways related to Hemangioendothelioma according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.3PGF
2
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10.0F13A1, PLG, PECAM1
310.0FLT1, FLT4, MDM2
4
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10.0PLG, FLT1, MDM2
510.0MDM2, EDN1, VHL
6
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10.0FLT4, FLT1, PGF
7
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10.0PGF, FLT1, FLT4
8
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10.0FLT4, FLT1, PGF
99.9VHL, FLT4, FLT1, PECAM1
10
Hide members
9.9MDM2, FLT4, FLT1, IL2
119.8FLI1, CD34, IL2, PECAM1
12
Hide members
9.8MDM2, FLT4, FLT1, PGF
13
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9.8CAV1, FLT4, FLT1, PGF
14
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9.7IFNA2, FLT4, FLT1, PGF, IL2
15
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9.7IL2, PGF, FLT1, FLT4, MDM2
16
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9.7CAV1, FLT4, FLT1, PGF, IL2
17
Hide members
9.7PGF, FLT1, FLT4, CAV1, VHL
18
Hide members
9.6IL2, CD34, MDM2, S100B, IFNA2, VHL
199.6IFNA2, MDM2, FLT4, FLT1, PGF, IL2
20
Hide members
8.8S100B, WWTR1, EDN1, MDM2, FLT4, FLT1

Compounds for genes affiliated with Hemangioendothelioma

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Hemangioendothelioma according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1sialic acid4510.6PECAM1
2cycloheximide4510.6CAV1
3estrogen4510.5F13A1, CALB2
4zm 323881 hydrochloride6010.5FLT4, FLT1
5zm 306416 hydrochloride6010.5FLT4, FLT1
6ki 87516010.5FLT4, FLT1
7dmh46010.5FLT1, FLT4
8thapsigargin45 6011.5MDM2
9indomethacin45 60 29 1113.5PGF, PGR
10tamoxifen45 50 29 1113.4IL2, PLG, PGR
11sorafenib45 50 1112.3FLT4, FLT1, IL2, VHL
12thalidomide45 50 60 1113.3IFNA2, CAV1, PLG, IL2
13p0034510.2PECAM1, FLT1, S100B, MDM2
14cyclosporin a45 29 6012.2PECAM1, PGR, S100B, EDN1
15dexamethasone45 50 29 1113.2S100B, CAV1, MDM2
16intron a4510.2IL2, IFNA2
17glucose4510.2CAV1, PGF, IFNA2, FLT1
18sunitinib45 50 1112.1IL2, PGF, FLT1, FLT4, VHL
19b 7234510.1PDPN, F13A1, CALB2, S100B
20cyclophosphamide45 50 1112.1PGR, IFNA2, MDM2, IL2
21steroid4510.1CALB2, MDM2, PLG, IFNA2, CAV1
22ribonucleic acid4510.0PGF, FLT1, PGR, PECAM1, IFNA2
23rapamycin4510.0FLT4, FLT1, IL2, PECAM1, MDM2, VHL
24bq78845 2911.0CAV1, EDN1
25prostacyclin4510.0CAV1, PGF, FLT1, PECAM1, EDN1
265-aza-2deoxycytidine4510.0CAV1, PGR, MDM2, VHL
27agar4510.0PECAM1, PGR, CAV1, IFNA2, MDM2, CD34
28iron45 2411.0VHL, IFNA2, S100B, MDM2, F13A1, CAV1
29actinomycin d4510.0PECAM1, IL2, MDM2, VHL, EDN1
30matrigel4510.0PGF, FLT1, FLT4, CAV1, PLG, PECAM1
31serine4510.0PLG, CAV1, PECAM1, VHL, S100B, FLT1
32doxorubicin45 50 1112.0FLT1, PGR, MDM2, CAV1, IFNA2
33mizoribine459.9IFNA2, IL2
34genistein45 29 60 2 11 2414.9EDN1, CAV1, MDM2, FLT1, PGR, IL2
35lysine459.9IFNA2, PLG, F13A1, MDM2, VHL
36paclitaxel45 50 1111.8S100B, PGR, PLG, FLT4, MDM2, CALB2
37heparin45 29 11 2412.8PLG, PECAM1, S100B, CAV1, FLT1, F13A1
38cisplatin45 50 60 1112.8IFNA2, MDM2, FLT1, IL2, CAV1
39cysteine459.7PLG, CAV1, IFNA2, MDM2, PGR, PECAM1
40retinoic acid45 2410.7PECAM1, FLT4, PGR, CD34, IFNA2, S100B
41hematoxylin459.6S100B, FLT1, F13A1, CD34, PLG, PECAM1
42phosphatidylinositol459.5CAV1, VHL, EDN1, MDM2, FLT1, PGF
43progesterone45 60 29 11 2413.4CAV1, CALB2, IFNA2, FLT1, S100B, PGR
44thymidine45 2410.4IFNA2, IL2, CD34, PLG, PECAM1, S100B
45nitric oxide45 11 2411.3VHL, CALB2, S100B, EDN1, MDM2, FLT1
46oxygen45 2410.3IFNA2, S100B, EDN1, MDM2, PLG, PGF
47calcium45 50 11 2412.1S100B, FLT1, CALB2, PECAM1, PLG, PGF
48paraffin458.9FLT1, F13A1, CD34, PGR, PECAM1, PGF
49tyrosine458.7CD34, PGF, IL2, PLG, S100B, PECAM1
50vegf458.2S100B, FLT4, MDM2, EDN1, PDPN, IFNA2

GO Terms for genes affiliated with Hemangioendothelioma

Sources:
16Gene Ontology
See all sources

Cellular components related to Hemangioendothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.3S100B, EDN1, FLT4, F13A1, PGF, IL2
2extracellular spaceGO:0056159.0PECAM1, IFNA2, S100B, EDN1, FLT1, PGF

Biological processes related to Hemangioendothelioma according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1glomerular endothelium developmentGO:07201110.4PECAM1, CD34
2positive regulation of odontogenesisGO:04248210.3CD34, EDN1
3positive regulation of sarcomere organizationGO:06029810.3EDN1, PROX1
4sprouting angiogenesisGO:00204010.3FLT4, FLT1, PGF
5vascular endothelial growth factor receptor signaling pathwayGO:04801010.3FLT4, FLT1, PGF
6lymphangiogenesisGO:00194610.2PROX1, FLT4, PDPN
7positive regulation of endothelial cell migrationGO:01059510.2PROX1, EDN1, FLT4
8positive regulation of endothelial cell proliferationGO:00193810.1FLT4, PGF, PROX1
9negative regulation of blood coagulationGO:03019510.1EDN1, CD34
10negative regulation of gene expressionGO:01062910.1IFNA2, CD34, PGR
11cellular response to hypoxiaGO:07145610.1VHL, S100B, MDM2
12platelet degranulationGO:00257610.0PECAM1, F13A1, PLG
13cell-cell signalingGO:00726710.0IFNA2, EDN1, PGF, PGR, IL2
14blood coagulationGO:0075969.9CAV1, PLG, IFNA2, F13A1, PECAM1
15negative regulation of nitric oxide biosynthetic processGO:0450199.8CAV1, CD34
16positive regulation of angiogenesisGO:0457669.8FLT1, CD34, PGF
17negative regulation of transcription from RNA polymerase II promoterGO:0001229.7MDM2, EDN1, WWTR1, CAV1, VHL, PROX1
18positive regulation of cell proliferationGO:0082849.3PROX1, S100B, WWTR1, FLT1, EDN1, MDM2

Molecular functions related to Hemangioendothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1vascular endothelial growth factor-activated receptor activityGO:0050219.9FLT4, FLT1
2enzyme bindingGO:0198999.9PGR, MDM2, CAV1, VHL
3protein bindingGO:0055158.3PECAM1, VHL, CAV1, IFNA2, S100B, WWTR1

Products for genes affiliated with Hemangioendothelioma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Hemangioendothelioma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet