MCID: HMN016
MIFTS: 45

Hemangioendothelioma malady

Rare diseases category
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Summaries for Hemangioendothelioma

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43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 The term hemangioendothelioma describes several types of vascular neosplasms and includes both non-cancerous (benign) and cancerous (malignant) growths. the term has also been applied to those that show "borderline" behavior, intermediate between entirely benign hemangiomas and highly malignant angiosarcomas. hemangioendotheliomas are caused by abnormal growth of blood vessel cells, although the exact underlying cause for the abnormal growth is unknown. they can also develop in an organ, such as the liver or lung. they usually grow slowly and can sometimes spread to other tissues in the body (metastasize). examples of types of hemangioendotheliomas include spindle cell hemangioma; papillary intralymphatic (dabska tumor); retiform; kaposiform; epithelioid; pseudomyogenic (epithelioid sarcoma-like hemangioendothelioma); and composite. treatment depends on the type of hemangioendothelioma present but typically includes surgical excision (removal). last updated: 7/10/2013

MalaCards: Hemangioendothelioma is related to epithelioid hemangioendothelioma and hemangioma. An important gene associated with Hemangioendothelioma is IFNA2 (interferon, alpha 2), and among its related pathways are Cytokine Network and Cytosolic sensors of pathogen-associated DNA. The compounds mizoribine and intron a have been mentioned in the context of this disorder. Affiliated tissues include liver, lung and bone, and related mouse phenotypes are cardiovascular system and liver/biliary system.

Wikipedia:65 Hemangioendothelioma is used to describe a group of vascular neoplasms that may be considered benign as... more...

Aliases & Classifications for Hemangioendothelioma

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43NIH Rare Diseases, 45Novoseek, 62UMLS
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Classifications:

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Global: Rare diseases


Aliases & Descriptions:

hemangioendothelioma 43 45 62


Related Diseases for Hemangioendothelioma

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17GeneCards, 18GeneDecks
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Diseases related to Hemangioendothelioma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 143)
idRelated DiseaseScoreTop Affiliating Genes
1epithelioid hemangioendothelioma31.9IFNA2, FLT4
2hemangioma30.8PECAM1, FLT4, IFNA2
3angiosarcoma30.7FLT4, PECAM1
4sarcoma30.6PECAM1, FLT4, IL2, S100B
5lymphangioma30.2PECAM1, FLT4
6kaposi's sarcoma30.0IFNA2, FLT4, PECAM1
7adenocarcinoma29.9PLG, FLT4, PECAM1
8eosinophilia29.9IL2, IFNA2
9pyogenic granuloma29.9FLT4, PECAM1
10thrombocytopenia29.7PLG, IL2, IFNA2, PECAM1
11melanoma29.5PECAM1, FLT4, IFNA2, IL2, PLG, S100B
12hepatitis10.9
13kaposiform hemangioendothelioma10.9
14mediastinitis10.4
15epithelioid sarcoma10.4
16endotheliitis10.4
17tufted angioma10.3
18spindle cell hemangioma10.3
19hypothyroidism10.2
20thyroiditis10.2
21cavernous hemangioma10.1
22cervicitis10.1
23pericardial effusion10.1
24lymphangiomatosis10.1
25aneurysm10.1
26papilloma10.1FLT4, IFNA2
27sezary's disease10.1IFNA2, IL2
28hairy cell leukemia10.1IL2, IFNA2
29factor vii deficiency10.1IL2, IFNA2
30mycosis fungoides10.1IFNA2, IL2
31spindle cell sarcoma10.1S100B, FLT4
32leukopenia10.1IL2, IFNA2
33cutaneous t cell lymphoma10.1IFNA2, IL2
34kidney rhabdoid cancer10.0IL2, IFNA2
35kidney cancer10.0IFNA2, IL2
36lichen planus10.0IFNA2, PECAM1
37hepatitis c10.0IL2, IFNA2
38histiocytoid hemangioma10.0
39fibroma10.0
40cystic lymphangioma10.0
41cerebritis10.0
42primary biliary cirrhosis10.0
43hemangiopericytoma10.0
44hepatoblastoma10.0
45histiocytoma10.0
46lymphedema10.0
47graft versus host disease10.0PECAM1, IL2
48vascular cancer10.0PLG, FLT4
49b-cell chronic lymphocytic leukemia10.0IL2, PECAM1
50intraocular melanoma10.0S100B, PLG

Graphical network of the top 20 diseases related to Hemangioendothelioma:



Diseases related to hemangioendothelioma

Symptoms for Hemangioendothelioma

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Drugs & Therapeutics for Hemangioendothelioma

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42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Hemangioendothelioma

Search NIH Clinical Center for Hemangioendothelioma

Genetic Tests for Hemangioendothelioma

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Anatomical Context for Hemangioendothelioma

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33MalaCards
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MalaCards organs/tissues related to Hemangioendothelioma:

33
Liver, Lung, Bone, Endothelial, Lymph node, Skin, Heart, Kidney, Thyroid, Spleen, Spinal cord, Breast, Cervix, Colon, Brain, Testis, Monocytes, Tonsil, Ovary, Salivary gland, Pancreas, Bone marrow, Small intestine, Thymus, Tongue

Animal Models for Hemangioendothelioma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Hemangioendothelioma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053858.1PLG, IL2, FLT4, PECAM1
2MP:00053708.0PLG, IL2, FLT4, PECAM1
3MP:00053817.8PECAM1, FLT4, IL2, PLG

Publications for Hemangioendothelioma

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52PubMed
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Articles related to Hemangioendothelioma:

(show top 50)    (show all 709)
idTitleAuthorsYear
1
Case of high-risk epithelioid hemangioendothelioma of the neck. (23019156)
2013
2
Recurrent hepatic epithelioid hemangioendothelioma after orthotopic liver transplantation. (24122824)
2013
3
A rare case of primary nodal hemangioendothelioma. (24260072)
2013
4
Hepatic epithelioid hemangioendothelioma treated with irreversible electroporation and antibiotics. (23897957)
2013
5
Management of synchronous vascular and ductal anomalies in living donor liver transplantation for hepatic epithelioid hemangioendothelioma. (24166881)
2013
6
Mediastinal epithelioid hemangioendothelioma with abundant spindle cells and osteoclast-like giant cells mimicking malignant fibrous histiocytoma. (23800015)
2013
7
Epithelioid hemangioendothelioma of sphenoid bone: a case report of an unusual case. (22824706)
2012
8
Primary Pulmonary Epithelioid Hemangioendothelioma: A Rare Cause of PET-Negative Pulmonary Nodules. (21869893)
2011
9
Mediastinal epithelioid hemangioendothelioma mimicking a teratoma. (21492982)
2011
10
Pseudomyogenic hemangioendothelioma: a distinctive, often multicentric tumor with indolent behavior. (21263239)
2011
11
Spindle cell hemangioendothelioma of the temporal muscle resected with zygomatic osteotomy: a case report of an unusual intramuscular lesion mimicking sarcoma. (22606579)
2011
12
Epithelioid hemangioendothelioma of nasal cavity. (21346909)
2010
13
Retiform hemangioendothelioma presenting as a hyperhidrotic tumor. (20883275)
2010
14
Lenalidomide stops progression of multifocal epithelioid hemangioendothelioma including intracranial disease. (19898746)
2010
15
Expression of prox1, lymphatic endothelial nuclear transcription factor, in Kaposiform hemangioendothelioma and tufted angioma. (20975337)
2010
16
Inhibiting the VEGF-VEGFR pathway in angiosarcoma, epithelioid hemangioendothelioma, and hemangiopericytoma/solitary fibrous tumor. (20485168)
2010
17
Education and imaging. Hepatobiliary and pancreatic: Epithelioid hemangioendothelioma. (19335787)
2009
18
Vincristine and corticosteroids as first-line treatment of Kasabach-Merritt syndrome in kaposiform hemangioendothelioma. (19426625)
2009
19
Nodal and extranodal soft tissue polymorphous hemangioendothelioma: a case report and review of the literature. (19366064)
2009
20
Hepatic epithelioid hemangioendothelioma (HEH) at MRI using reticuloendothelial system (RES)-specific contrast agent: the "bright-bright sign" rather than the "bright-dark sign". (19306449)
2009
21
Epithelioid hemangioendothelioma of the oral cavity: a case report. (18587215)
2008
22
Pulmonary epithelioid hemangioendothelioma: report of three cases. (18751952)
2008
23
Meningel intracranial epithelioid hemangioendothelioma: case report and literature review. (18278439)
2008
24
Epitheloid hemangioendothelioma of urinary bladder. (19468406)
2008
25
Liver transplantation for hepatic epithelioid hemangioendothelioma: a case series. (17484250)
2007
26
Spindle cell hemangioendothelioma. (17388212)
2007
27
Pulmonary metastasis from hepatic epithelioid hemangioendothelioma; report of a case]. (17564071)
2007
28
Spindle cell hemangioma and epithelioid hemangioendothelioma arising in an area of lymphedema. (16778491)
2006
29
Multifocal penile epithelioid hemangioendothelioma masquerading as superficial penile vein thrombosis. (16979710)
2006
30
Incidental in vivo detection of an epithelioid hemangioendothelioma of the mitral valve. (16185295)
2005
31
Epithelioid hemangioendothelioma of the spine. Report of two cases. (16302636)
2005
32
Right upper quadrant pain and fever in a 41-year-old man. Epithelioid hemangioendothelioma of the liver with metastasis to porta hepatis lymph nodes and lung. (15859662)
2005
33
A key angiogenic role of monocyte chemoattractant protein-1 in hemangioendothelioma proliferation. (15163622)
2004
34
Pathology quiz case 2. Diagnosis: Kaposiform hemangioendothelioma (KHE). (15313873)
2004
35
Malignant intracranial epithelioid hemangioendothelioma presumably originating from the lung: case report. (15164990)
2004
36
Epithelioid hemangioendothelioma of the liver with F-18 FDG PET imaging. (15545895)
2004
37
Transformation between Kaposiform hemangioendothelioma and tufted angioma. (12771476)
2003
38
Pulmonary epithelioid hemangioendothelioma coexistent with pulmonary metastasis of thyroid cancer. (11518122)
2001
39
Vascular endothelial growth factor receptor-3 (VEGFR-3): a marker of vascular tumors with presumed lymphatic differentiation, including Kaposi's sarcoma, kaposiform and Dabska-type hemangioendotheliomas, and a subset of angiosarcomas. (10697276)
2000
40
Epithelioid hemangioendothelioma of the liver--characteristics on magnetic resonance imaging: case report. (10659062)
1999
41
Kaposiform hemangioendothelioma: a locally aggressive vascular tumor. (9591789)
1998
42
Epithelioid hemangioendothelioma of soft tissue: report of a case with ultrastructural observations. (9491218)
1998
43
Human angiostatin inhibits murine hemangioendothelioma tumor growth in vivo. (9393749)
1997
44
Malignant epithelioid hemangioendothelioma of the tibia associated with a bone infarct in a patient who had Gaucher disease. A case report. (7744904)
1995
45
CT of pulmonary epithelioid hemangioendothelioma. (8040439)
1994
46
Cutaneous epithelioid hemangioendothelioma without systemic involvement. (8517499)
1993
47
Epithelioid hemangioendothelioma of the lung (intravascular bronchioloalveolar tumor) in a young girl. (1661888)
1991
48
A case of malignant hemangioendothelioma effectively treated with intra-arterial continuous infusion of interleukin-2]. (1877838)
1991
49
Malignant epithelioid hemangioendothelioma at the site of a hip prosthesis. (3381668)
1988
50
Intravascular bronchioloalveolar tumor as a secondary manifestation of an epithelioid hemangioendothelioma. (3818539)
1986

Variations for Hemangioendothelioma

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Expression for genes affiliated with Hemangioendothelioma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Hemangioendothelioma

Search GEO for disease gene expression data for Hemangioendothelioma.

Pathways for genes affiliated with Hemangioendothelioma

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50PathCards, 53QIAGEN, 55Reactome, 30KEGG, 5Cell Signaling Technology, 60Thomson Reuters, 38NCBI BioSystems Database
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Pathways related to Hemangioendothelioma according to GeneCards/GeneDecks:

(show all 12)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5IFNA2, IL2
2
Show member pathways
9.5S100B, IFNA2
3
Show member pathways
9.5S100B, IFNA2
49.4PECAM1, FLT4
5
Show member pathways
IL23-mediated signaling events38
Immune response IL 10 signaling pathway60
Angiopoietin receptor Tie2-mediated signaling38
Development PDGF signaling via STATs and NF kB60
Development Angiopoietin Tie2 signaling60
9.1PLG, IL2
6
Show member pathways
9.1IL2, IFNA2, FLT4
7
Show member pathways
9.1IL2, FLT4, IFNA2
89.1IL2, IFNA2, FLT4
9
Show member pathways
9.0PECAM1, PLG
10
Show member pathways
8.7IFNA2, IL2, PLG
11
Show member pathways
8.7PLG, IL2, FLT4
12
Show member pathways
8.6PLG, IFNA2, PECAM1

Compounds for genes affiliated with Hemangioendothelioma

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45Novoseek, 11DrugBank, 61Tocris Bioscience, 29IUPHAR, 51PharmGKB, 3BitterDB, 24HMDB
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Compounds related to Hemangioendothelioma according to GeneCards/GeneDecks:

(show top 50)    (show all 55)
idCompoundScoreTop Affiliating Genes
1mizoribine4510.0IL2, IFNA2
2intron a4510.0IL2, IFNA2
3fotemustine45 1111.0IFNA2, IL2
4cidofovir45 1111.0IFNA2, IL2
5pentostatin45 61 29 1113.0IL2, IFNA2
6levamisole45 1111.0IL2, IFNA2
7dacarbazine45 1111.0IFNA2, IL2
8temozolomide45 1110.9IFNA2, IL2
9isotretinoin45 1110.9IFNA2, IL2
10bcnu459.9IFNA2, IL2
11con a459.9IL2, IFNA2
12sunitinib45 51 1111.9FLT4, IL2
132,5-oligoadenylate459.9IFNA2, IL2
143-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.9IFNA2, S100B
15ribavirin45 51 1111.8IFNA2, IL2
16ifn-alpha459.8IL2, IFNA2
17sorafenib45 51 1111.8IL2, FLT4
18neopterin459.8IFNA2, IL2
19rituximab45 51 1111.8IL2, IFNA2
20vinblastine45 51 1111.8IL2, IFNA2
21colchicine45 61 3 29 1113.7S100B, IFNA2
22zidovudine45 51 1111.7IFNA2, IL2
23mitomycin c459.5IFNA2, IL2
24azathioprine45 3 51 1112.4IL2, IFNA2
25carboplatin45 51 1111.4PLG, IFNA2
26histamine45 29 2411.3PECAM1, IFNA2, IL2
27rapamycin459.2IL2, FLT4, PECAM1
28paraffin459.2S100B, FLT4, PECAM1
29thalidomide45 51 61 1112.2IFNA2, IL2, PLG
30cyclosporin a45 29 6111.1S100B, IL2, PECAM1
31histidine459.1S100B, PLG, IFNA2
32tamoxifen45 51 29 1112.1IFNA2, IL2, PLG
33paclitaxel45 51 1111.1S100B, PLG, FLT4
34dexamethasone45 51 29 1112.0S100B, IL2, FLT4
35p003459.0S100B, PECAM1
36matrigel459.0PLG, FLT4, PECAM1
37hematoxylin459.0S100B, PLG, PECAM1
38estrogen458.9PECAM1, FLT4, IFNA2, S100B
39retinoic acid45 249.9S100B, IFNA2, FLT4, PECAM1
40steroid458.8IFNA2, PLG, S100B
41heparin45 29 24 1111.8PECAM1, PLG, S100B
42nitric oxide45 24 1110.5S100B, PLG, PECAM1
43cysteine458.5S100B, PLG, IFNA2, PECAM1
44glucose458.5PECAM1, IFNA2, PLG, S100B
45lipid458.5PECAM1, IFNA2, PLG, S100B
46serine458.3S100B, PLG, IL2, PECAM1
47oxygen45 249.1PECAM1, FLT4, IFNA2, PLG, S100B
48thymidine45 249.0PECAM1, IFNA2, IL2, PLG, S100B
49vegf457.6S100B, PLG, IL2, IFNA2, FLT4, PECAM1
50tyrosine457.6PECAM1, FLT4, IFNA2, IL2, PLG, S100B

GO Terms for genes affiliated with Hemangioendothelioma

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16Gene Ontology
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Cellular components related to Hemangioendothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055767.7IFNA2, IL2, PLG, S100B, FLT4
2extracellular spaceGO:0056157.3S100B, PLG, IL2, IFNA2, PECAM1

Biological processes related to Hemangioendothelioma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet degranulationGO:0025769.0PLG, PECAM1
2positive regulation of cell proliferationGO:0082848.9S100B, IL2, FLT4
3blood coagulationGO:0075968.3PLG, IFNA2, PECAM1

Products for genes affiliated with Hemangioendothelioma

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Sources for Hemangioendothelioma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet